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chr12:55,677,395-58,897,077

Best TWAS P=6.86e-24 · Best GWAS P=7.71e-14 conditioned to 0.655

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Brain Putamen basal ganglia	RP11-977G19.11	0.30	0.15	enet	33	0.20	1.5e-05	-6.687	10.1	6.9e-24	-0.50	0.04	0.89	TRUE
3	CommonMind	Brain Pre-frontal Cortex	PRIM1	0.31	0.24	enet	7	0.24	1.1e-28	-6.465	6.5	8.1e-11	-0.06	0.74	0.26	TRUE
59	GTEx	Whole Blood	RBMS2	0.16	0.15	enet	20	0.15	1.0e-13	6.428	-6.0	1.7e-09	0.43	0.74	0.26	TRUE
46	GTEx	Pituitary	SUOX	0.44	0.13	enet	20	0.27	1.4e-07	-5.316	5.6	1.8e-08	0.08	0.15	0.09	TRUE
58	GTEx	Vagina	TSFM	0.16	-0.01	lasso	8	0.02	1.4e-01	-5.128	5.4	6.5e-08	-0.04	0.06	0.32	TRUE
44	GTEx	Pancreas	RBMS2	0.10	0.02	lasso	14	0.00	2.2e-01	-7.351	-8.8	1.6e-18	0.78	0.04	0.73	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RBMS2	0.25	-0.01	lasso	13	-0.01	9.5e-01	-7.462	-8.8	1.9e-18	0.27	0.04	0.34	FALSE
35	GTEx	Esophagus Muscularis	RP11-977G19.11	0.12	0.06	lasso	2	0.10	2.2e-06	-6.695	8.6	6.8e-18	-0.69	0.04	0.93	FALSE
91	The Cancer Genome Atlas	Thyroid Carcinoma	SPRYD4	0.22	0.11	blup	34	0.12	1.8e-11	-7.475	-8.1	5.7e-16	0.79	0.00	1.00	FALSE
19	GTEx	Brain Hippocampus	RP11-977G19.11	0.25	0.21	lasso	5	0.16	1.1e-04	-6.654	7.8	5.7e-15	-0.50	0.18	0.43	FALSE
17	GTEx	Brain Cortex	RP11-977G19.11	0.38	0.16	lasso	9	0.12	3.8e-04	-6.689	7.7	1.8e-14	-0.47	0.12	0.45	FALSE
67	YFS	Blood	SPRYD4	0.39	0.34	lasso	5	0.36	3.7e-126	-7.136	-7.4	1.1e-13	0.91	0.06	0.94	FALSE
88	The Cancer Genome Atlas	Stomach Adenocarcinoma	SPRYD4	0.07	0.05	lasso	3	0.03	2.0e-03	-7.136	-7.2	8.0e-13	0.85	0.01	0.94	FALSE
81	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SPRYD4	0.07	0.06	blup	34	0.05	2.2e-06	-7.136	-7.1	9.0e-13	0.85	0.01	0.99	FALSE
5	GTEx	Adipose Subcutaneous	RP11-977G19.11	0.12	0.10	lasso	7	0.09	7.5e-08	-6.652	7.1	9.3e-13	-0.28	0.54	0.46	FALSE
63	NTR	Blood	OBFC2B	0.01	0.00	bslmm	248	0.00	3.6e-02	-1.067	7.1	1.5e-12	-0.16	0.05	0.03	FALSE
84	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SPRYD4	0.24	0.00	enet	8	0.06	1.8e-03	-7.475	-7.0	3.1e-12	0.76	0.00	0.86	FALSE
78	The Cancer Genome Atlas	Lung Adenocarcinoma	MIP	0.07	0.03	blup	35	0.02	1.2e-03	-6.890	-7.0	3.6e-12	0.74	0.00	0.92	FALSE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	STAT2	0.02	0.02	blup	21	0.01	9.6e-03	-6.681	-6.9	7.2e-12	0.30	0.01	0.86	FALSE
31	GTEx	Colon Transverse	RP11-977G19.11	0.18	0.05	lasso	2	0.00	1.9e-01	-6.695	6.8	1.3e-11	-0.29	0.12	0.13	FALSE
43	GTEx	Ovary	RPS26	0.50	0.24	enet	25	0.22	5.0e-06	-5.188	-6.8	1.3e-11	0.03	0.74	0.04	FALSE
16	GTEx	Brain Cerebellum	RP11-977G19.11	0.17	0.19	lasso	14	0.18	5.4e-06	-6.654	6.8	1.4e-11	-0.28	0.39	0.40	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CNPY2	0.06	0.05	lasso	8	0.05	2.3e-06	-6.681	6.7	1.5e-11	-0.29	0.56	0.44	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	RP11-977G19.11	0.30	0.12	lasso	10	0.08	4.6e-03	-6.652	6.8	1.5e-11	-0.29	0.20	0.27	FALSE
6	GTEx	Adrenal Gland	RP11-977G19.11	0.19	0.16	lasso	15	0.09	3.9e-04	-6.695	6.7	1.6e-11	-0.28	0.49	0.43	FALSE
29	GTEx	Cells Transformed fibroblasts	RP11-977G19.11	0.11	0.07	enet	22	0.05	9.5e-05	-6.689	6.7	1.8e-11	-0.29	0.54	0.45	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	COQ10A	0.03	0.03	lasso	2	0.03	9.1e-04	-6.695	6.7	1.8e-11	-0.29	0.01	0.92	FALSE
36	GTEx	Liver	STAT2	0.32	0.17	lasso	13	0.14	9.9e-05	-6.654	-6.7	1.9e-11	0.27	0.49	0.41	FALSE
39	GTEx	Nerve Tibial	IL23A	0.06	0.08	lasso	10	0.07	1.6e-05	-6.652	-6.7	1.9e-11	0.30	0.50	0.43	FALSE
40	GTEx	Nerve Tibial	STAT2	0.08	0.05	lasso	3	0.03	5.0e-03	-6.652	6.7	1.9e-11	-0.31	0.28	0.26	FALSE
45	GTEx	Pancreas	IL23A	0.23	0.01	lasso	13	0.04	1.1e-02	-6.654	-6.7	1.9e-11	0.27	0.54	0.46	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	IL23A	0.03	0.03	blup	22	0.02	1.8e-03	-6.641	-6.7	2.0e-11	0.31	0.01	0.82	FALSE
41	GTEx	Nerve Tibial	RP11-977G19.11	0.15	0.18	enet	23	0.20	7.7e-14	-6.689	6.7	2.1e-11	-0.30	0.55	0.46	FALSE
25	GTEx	Breast Mammary Tissue	RP11-977G19.11	0.11	0.08	lasso	8	0.04	2.5e-03	-6.689	6.7	2.2e-11	-0.29	0.24	0.24	FALSE
33	GTEx	Esophagus Mucosa	RP11-977G19.11	0.07	0.09	lasso	1	0.07	1.5e-05	-6.695	6.7	2.2e-11	-0.29	0.52	0.45	FALSE
27	GTEx	Cells Transformed fibroblasts	PAN2	0.09	0.07	lasso	4	0.05	1.7e-04	-6.652	-6.7	2.3e-11	0.26	0.52	0.43	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL23A	0.03	0.04	lasso	7	0.04	2.9e-05	-6.681	-6.7	2.4e-11	0.29	0.01	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PAN2	0.05	0.07	lasso	3	0.06	5.4e-08	-6.654	-6.7	2.8e-11	0.27	0.55	0.46	FALSE
7	GTEx	Artery Aorta	RP11-977G19.11	0.26	0.28	lasso	14	0.28	5.3e-16	-6.654	6.7	2.8e-11	-0.27	0.55	0.46	FALSE
11	GTEx	Artery Tibial	RP11-977G19.11	0.16	0.18	lasso	12	0.18	6.1e-14	-6.654	6.7	2.8e-11	-0.27	0.55	0.46	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	RP11-977G19.11	0.18	0.14	lasso	13	0.07	2.0e-03	-6.654	6.7	2.8e-11	-0.27	0.42	0.36	FALSE
48	GTEx	Pituitary	CNPY2	0.32	0.19	lasso	11	0.12	6.8e-04	-6.654	-6.7	2.8e-11	0.27	0.23	0.27	FALSE
55	GTEx	Thyroid	IL23A	0.07	0.04	lasso	10	0.00	1.9e-01	-6.654	-6.7	2.8e-11	0.27	0.30	0.26	FALSE
23	GTEx	Brain Putamen basal ganglia	RP11-973D8.4	0.18	0.21	lasso	1	0.14	4.3e-04	-6.646	6.6	3.0e-11	-0.29	0.12	0.36	FALSE
65	YFS	Blood	CNPY2	0.02	0.02	lasso	1	0.02	5.8e-07	-6.641	-6.6	3.1e-11	0.28	0.57	0.43	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	NABP2	0.12	0.12	lasso	4	0.13	2.7e-16	-6.654	-6.6	3.2e-11	0.27	0.55	0.45	FALSE
57	GTEx	Thyroid	CNPY2	0.06	0.02	lasso	10	0.02	2.1e-02	-6.646	-6.6	4.0e-11	0.29	0.40	0.33	FALSE
52	GTEx	Skin Sun Exposed Lower leg	CNPY2	0.10	0.08	lasso	5	0.08	5.9e-07	-6.654	-6.6	4.5e-11	0.26	0.53	0.45	FALSE
18	GTEx	Brain Frontal Cortex BA9	RP11-977G19.11	0.30	0.34	lasso	5	0.32	3.5e-09	-6.695	6.6	5.3e-11	-0.34	0.54	0.45	FALSE
47	GTEx	Pituitary	RP11-977G19.11	0.47	0.40	lasso	14	0.40	4.5e-11	-6.689	6.6	5.6e-11	-0.27	0.54	0.46	FALSE
51	GTEx	Skin Sun Exposed Lower leg	RP11-977G19.11	0.15	0.09	lasso	11	0.08	1.9e-07	-6.689	6.5	6.6e-11	-0.30	0.54	0.45	FALSE
9	GTEx	Artery Coronary	RP11-977G19.11	0.24	0.14	lasso	13	0.08	1.2e-03	-6.689	6.5	9.4e-11	-0.26	0.37	0.33	FALSE
69	The Cancer Genome Atlas	Glioblastoma Multiforme	PAN2	0.08	0.04	blup	31	0.03	4.4e-02	-6.627	-6.4	1.4e-10	0.28	0.01	0.57	FALSE
38	GTEx	Lung	CNPY2	0.05	0.03	lasso	4	0.00	1.7e-01	-6.652	-6.3	2.7e-10	0.31	0.26	0.23	FALSE
49	GTEx	Prostate	SUOX	0.22	0.04	enet	11	0.05	2.3e-02	-4.667	6.2	6.0e-10	0.05	0.03	0.84	FALSE
20	GTEx	Brain Hypothalamus	RP11-977G19.11	0.32	0.20	lasso	6	0.23	4.4e-06	-6.646	6.2	6.1e-10	-0.33	0.47	0.40	FALSE
26	GTEx	Breast Mammary Tissue (Female)	RPS26	0.20	0.11	lasso	3	0.10	6.6e-04	-4.692	-6.2	7.6e-10	0.19	0.03	0.48	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	STAT2	0.07	0.04	enet	10	0.04	1.9e-03	-6.646	-6.1	8.5e-10	0.37	0.01	0.80	FALSE
66	YFS	Blood	RBMS2	0.47	0.26	enet	59	0.48	2.0e-183	-1.672	-6.1	9.1e-10	0.44	1.00	0.00	FALSE
13	GTEx	Brain Caudate basal ganglia	RP11-977G19.11	0.31	0.25	lasso	5	0.28	1.2e-08	-6.654	6.1	1.0e-09	-0.29	0.52	0.43	FALSE
82	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TIMELESS	0.05	0.03	enet	10	0.04	8.4e-06	1.809	-6.1	1.2e-09	0.53	0.04	0.90	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	RP11-977G19.11	0.16	0.11	enet	17	0.12	6.7e-07	-6.652	5.9	2.9e-09	-0.20	0.52	0.44	FALSE
28	GTEx	Cells Transformed fibroblasts	RPS26	0.11	0.08	enet	15	0.09	3.4e-07	-5.316	-5.9	4.0e-09	-0.11	0.99	0.01	FALSE
60	GTEx	Whole Blood	SUOX	0.07	0.01	enet	20	0.02	1.1e-02	-5.035	5.8	5.9e-09	0.08	0.32	0.14	FALSE
34	GTEx	Esophagus Muscularis	RPS26	0.19	0.06	enet	46	0.05	9.3e-04	-5.035	-5.7	1.5e-08	-0.03	0.15	0.11	FALSE
42	GTEx	Ovary	SUOX	0.23	0.14	enet	12	0.21	8.4e-06	-4.667	5.6	1.9e-08	0.02	0.14	0.10	FALSE
15	GTEx	Brain Cerebellum	RBMS2	0.25	0.05	lasso	5	0.14	4.6e-05	0.027	-5.6	2.1e-08	0.20	0.05	0.32	FALSE
37	GTEx	Lung	SUOX	0.34	0.23	enet	38	0.26	4.6e-20	-4.692	5.6	2.6e-08	0.10	0.99	0.01	FALSE
30	GTEx	Colon Transverse	SUOX	0.24	0.22	enet	24	0.25	3.8e-12	-4.692	5.5	3.9e-08	0.04	0.99	0.01	FALSE
24	GTEx	Breast Mammary Tissue	RPS26	0.29	0.05	enet	37	0.12	9.4e-07	-5.035	-5.5	4.8e-08	0.26	0.89	0.10	FALSE
56	GTEx	Thyroid	RP11-977G19.11	0.16	0.11	enet	20	0.13	3.5e-10	-6.695	5.4	8.6e-08	-0.30	0.54	0.46	FALSE
4	CommonMind	Brain Pre-frontal Cortex	RPS26	0.48	0.62	lasso	5	0.63	5.9e-99	-5.035	-5.3	1.2e-07	-0.09	1.00	0.00	FALSE
12	GTEx	Artery Tibial	RP11-571M6.17	0.04	0.01	lasso	2	0.00	1.2e-01	-5.292	5.3	1.2e-07	0.03	0.06	0.83	FALSE
53	GTEx	Spleen	SUOX	0.34	0.31	enet	15	0.28	5.4e-08	-4.692	5.3	1.2e-07	0.03	0.50	0.10	FALSE
10	GTEx	Artery Tibial	RPS26	0.07	0.02	enet	5	0.01	3.5e-02	-5.035	-5.3	1.3e-07	-0.11	0.27	0.07	FALSE
68	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RPS26	0.14	0.22	lasso	2	0.23	4.8e-19	-5.316	-5.3	1.4e-07	-0.09	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RPS26	0.17	0.29	lasso	4	0.29	6.2e-33	-5.316	-5.2	1.5e-07	-0.10	0.00	1.00	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS26	0.33	0.52	enet	9	0.54	5.6e-66	-5.035	-5.3	1.5e-07	-0.09	0.01	0.99	FALSE
8	GTEx	Artery Aorta	CNPY2	0.13	0.03	lasso	14	0.03	5.9e-03	-1.917	-5.2	1.8e-07	0.13	0.16	0.15	FALSE
87	The Cancer Genome Atlas	Stomach Adenocarcinoma	RPS26	0.19	0.32	lasso	5	0.34	2.0e-25	-5.316	-5.2	1.8e-07	-0.09	0.00	1.00	FALSE
62	METSIM	Adipose	RPS26	0.30	0.40	lasso	5	0.41	7.2e-66	-5.316	-5.2	1.9e-07	-0.09	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RPS26	0.36	0.44	lasso	7	0.42	2.4e-19	-5.316	-5.2	2.0e-07	-0.11	0.00	0.99	FALSE
61	METSIM	Adipose	IKZF4	0.04	0.04	enet	3	0.04	1.0e-06	-5.188	-5.2	2.1e-07	-0.09	1.00	0.00	FALSE
70	The Cancer Genome Atlas	Glioblastoma Multiforme	RPS26	0.41	0.38	enet	9	0.39	7.9e-13	-5.316	-5.2	2.1e-07	-0.10	0.00	1.00	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	COQ10A	0.04	0.02	lasso	3	0.03	5.2e-04	-6.646	5.2	2.1e-07	-0.33	0.01	0.86	FALSE
73	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SPRYD4	0.03	0.01	blup	34	0.02	1.0e-03	-7.475	-5.2	2.2e-07	0.80	0.00	0.92	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	RPS26	0.26	0.45	enet	9	0.47	3.6e-61	-5.035	-5.2	2.4e-07	-0.10	0.00	0.99	FALSE
74	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPS26	0.27	0.38	enet	8	0.40	5.0e-24	-5.035	-5.2	2.6e-07	-0.10	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	RPS26	0.33	0.51	enet	19	0.50	7.3e-56	-5.035	-5.1	2.6e-07	-0.11	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS26	0.31	0.53	enet	8	0.55	1.7e-74	-5.035	-5.1	2.9e-07	-0.10	0.01	0.99	FALSE
54	GTEx	Spleen	PIP4K2C	0.31	0.08	lasso	4	0.06	1.1e-02	-5.436	5.1	3.0e-07	0.04	0.04	0.35	FALSE