Best TWAS P=2.37e-35 · Best GWAS P=8.68e-61 conditioned to 4.19e-18
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CSE1L | 0.08 | 0.07 | bslmm | 503 | 0.05 | 1.7e-06 | -4.654 | -5.5 | 3.1e-08 | -0.10 | 0.53 | 0.47 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | DDX27 | 0.04 | 0.04 | enet | 11 | 0.07 | 7.3e-09 | -4.530 | 5.2 | 2.1e-07 | 0.04 | 0.30 | 0.69 | FALSE |
3 | GTEx | Adipose Subcutaneous | UBE2V1 | 0.11 | 0.05 | enet | 19 | 0.06 | 8.6e-06 | 2.307 | -6.3 | 2.8e-10 | 0.14 | 0.24 | 0.06 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | RP11-112L6.4 | 0.37 | 0.12 | enet | 32 | 0.08 | 3.7e-03 | 1.975 | 5.2 | 2.2e-07 | -0.29 | 0.09 | 0.18 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | RP11-112L6.4 | 0.29 | 0.25 | lasso | 5 | 0.22 | 1.8e-06 | 1.975 | 5.5 | 3.1e-08 | -0.20 | 0.43 | 0.05 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | PTPN1 | 0.11 | 0.00 | lasso | 4 | 0.00 | 4.5e-01 | -6.984 | -7.0 | 3.5e-12 | 0.16 | 0.05 | 0.05 | TRUE |
7 | GTEx | Colon Sigmoid | ARFGEF2 | 0.15 | 0.12 | lasso | 1 | 0.07 | 2.3e-03 | 5.987 | -6.0 | 2.1e-09 | -0.10 | 0.01 | 0.93 | TRUE |
8 | GTEx | Colon Transverse | FAM65C | 0.16 | 0.06 | lasso | 3 | 0.04 | 5.7e-03 | 12.048 | -12.4 | 2.4e-35 | 0.40 | 0.28 | 0.06 | TRUE |
9 | GTEx | Nerve Tibial | CSE1L | 0.12 | 0.01 | lasso | 10 | 0.03 | 5.7e-03 | -4.237 | -5.9 | 3.0e-09 | -0.09 | 0.19 | 0.24 | FALSE |
10 | GTEx | Nerve Tibial | PTPN1 | 0.11 | 0.01 | lasso | 3 | 0.01 | 5.4e-02 | 0.097 | 6.4 | 2.0e-10 | -0.28 | 0.10 | 0.24 | TRUE |
11 | GTEx | Nerve Tibial | TMEM189 | 0.18 | 0.00 | enet | 36 | 0.05 | 3.1e-04 | -1.592 | 10.2 | 2.9e-24 | -0.35 | 0.08 | 0.52 | TRUE |
12 | GTEx | Testis | FAM65C | 0.25 | -0.01 | enet | 52 | 0.00 | 3.1e-01 | -1.134 | -5.2 | 1.7e-07 | 0.26 | 0.05 | 0.26 | FALSE |
13 | GTEx | Testis | RP4-530I15.9 | 0.36 | 0.42 | lasso | 1 | 0.42 | 3.3e-20 | 11.697 | 11.7 | 1.3e-31 | -0.51 | 1.00 | 0.00 | FALSE |
14 | METSIM | Adipose | PARD6B | 0.03 | 0.00 | bslmm | 494 | 0.01 | 5.1e-02 | 6.375 | -9.6 | 9.9e-22 | 0.40 | 0.04 | 0.37 | TRUE |
15 | YFS | Blood | ZNFX1 | 0.06 | 0.05 | lasso | 3 | 0.05 | 1.4e-16 | 5.769 | -5.8 | 5.8e-09 | -0.07 | 0.01 | 0.99 | FALSE |