TWAS hub - PARD6B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0470	0.0210	0.013	0.009	0.002	0.006	0.006	0.009	0.024	0.170	0.051	0.061	0.022
2	METSIM	Adipose	0.0331	0.0161	0.015	-0.001	0.004	-0.002	0.005	-0.001	0.520	0.071	0.790	0.051	0.620

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Average weekly spirits intake	6.1	7.6	10.4	3.2	2.2
Birth weight	5.1	11.0	20.7	-4.5	-1.2
Blood Red Count	4.8	46.2	91.8	0.8	-9.6
Hand grip strength (right)	4.0	10.9	15.5	-2.5	-3.9
Serious illness, injury or assault to yourself	3.9	4.8	7.9	1.3	2.8
Schizophrenia vs Biploar Disorder	3.6	4.8	9.4	-3.1	-0.4
Allergy	3.4	7.9	10.5	-2.3	-3.2
Medication: Gliclazide	3.3	3.7	5.5	1.4	2.3
Tinnitus: Yes, but not now, but have in the past	3.1	3.3	6.4	-0.5	-2.5
Qualifications: nursing, teaching	3.1	4.8	9.5	-0.0	-3.1
Supplements: Fish oil (including cod liver oil)	3.1	4.0	6.0	2.4	1.5
Family relationship satisfaction	2.9	3.6	5.7	1.2	2.4
Ever highly irritable/argumentative for 2 days	2.8	3.4	5.5	1.1	2.3
Loud music exposure frequency	2.8	3.1	4.3	2.1	1.3
HbA1C	2.7	3.0	3.3	-1.6	-1.8
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	5.1	1.3	2.2
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.5	9.8	-1.1	-3.1
Average weekly beer plus cider intake	2.7	3.9	6.3	2.5	1.3
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.7	4.2	-1.1	2.1
LDL Cholesterol	2.4	3.9	4.0	-2.0	-1.9
Diabetes (self-reported)	2.4	3.8	6.7	2.6	0.9
Medication: Metformin	2.3	3.2	4.8	1.3	2.2
Hearing difficulty/problems with background noise	2.3	3.6	6.2	-1.0	-2.5
Hand grip strength (left)	2.2	5.9	6.5	-2.5	-2.3
Sitting height	2.2	15.5	23.5	-2.7	-4.8
Medication: Seretide 50 evohaler	2.2	2.6	5.1	-0.2	2.3
Mineral and other dietary supplements	2.2	2.9	4.2	-2.0	-1.3
Blood White Count	2.1	15.5	26.4	-2.1	-5.1
Asthma	2.1	4.2	7.8	0.7	2.8
Asthma (self-reported)	2.1	4.2	8.0	0.7	2.8
Eye problems/disorders: Glaucoma	2.1	2.5	5.1	2.3	0.1
Trunk fat-free mass	2.0	11.2	19.5	-1.7	-4.4
Trunk predicted mass	2.0	11.3	19.7	-1.7	-4.4
Glaucoma (self-reported)	2.0	2.3	4.0	2.0	0.8
Ovarian Cancer	1.9	2.6	3.3	1.4	1.8
Past tobacco smoking	1.9	3.6	6.5	0.8	-2.5
Wheeze or whistling in the chest in last year	1.9	3.4	5.3	1.2	2.3
Tinnitus: Yes, now most or all of the time	1.9	2.2	2.6	1.6	1.4
Breast Cancer	1.8	4.3	4.7	-2.0	-2.2
Crohns Disease (2012)	1.8	3.0	4.1	-2.0	-1.4
Schizophrenia (2014)	1.8	3.9	6.8	-2.6	1.0
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.5	-0.4	-2.1
Pulse wave reflection index	1.8	2.2	4.3	2.1	-0.4
Arm fat-free mass (right)	1.8	9.1	17.1	-1.0	-4.1
Arm predicted mass (right)	1.8	9.0	17.0	-1.0	-4.1
Townsend deprivation index at recruitment	1.7	2.4	2.5	1.6	1.5
Gout (self-reported)	1.7	2.3	3.6	1.9	-1.0
Whole body fat-free mass	1.7	9.8	16.3	-1.8	-4.0
Whole body water mass	1.7	9.8	15.8	-1.9	-4.0
Schizophrenia (2018)	1.6	3.4	6.2	-2.5	0.7
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	3.6	1.9	1.2
Worry too long after embarrassment	1.6	2.6	2.6	-1.6	-1.6
Pulse rate, automated reading	1.6	5.1	8.8	-3.0	-1.2
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.4	-0.7	1.8
Heart disease (siblings)	1.6	2.0	3.9	2.0	0.2
Medication: Amlodipine	1.5	2.1	3.7	1.9	-0.6
Pulse wave peak to peak time	1.5	1.7	3.5	-1.9	-0.1
Smoking status: Previous	1.5	2.2	2.8	-1.3	1.7
Back pain experienced in last month	1.5	2.1	2.5	1.6	-1.3
Basal metabolic rate	1.5	8.0	12.4	-1.9	-3.5
Arm fat-free mass (left)	1.5	7.6	13.3	-1.4	-3.6
Height	1.4	27.4	45.0	-3.1	-6.7
Blood clot in the leg (DVT)	1.4	1.8	2.5	1.6	1.0
Leg fat-free mass (right)	1.4	7.4	10.2	-2.1	-3.2
Average weekly red wine intake	1.4	2.0	4.0	2.0	0.1
Diabetes diagnosed by doctor	1.4	2.3	3.1	1.8	1.2
Leg predicted mass (right)	1.4	7.3	10.3	-2.1	-3.2
Arm predicted mass (left)	1.4	7.1	12.7	-1.2	-3.6
Alzheimer’s Disease (in father)	1.3	1.4	2.0	0.9	1.4
Crohns Disease (2017)	1.3	2.9	4.5	-1.2	-2.1
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	3.0	1.7	-1.0
Number of live births	1.3	1.9	2.6	-1.1	1.6
Standing height	1.3	13.3	18.6	-2.8	-4.3
Number of children fathered	1.3	1.5	3.0	-1.7	-0.0
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	2.2	1.5	1.1
Smoking Status	1.2	2.9	4.2	-1.2	2.1
Respiratory disease	1.2	2.6	5.0	0.4	2.2
Leg fat-free mass (left)	1.2	6.3	9.1	-1.9	-3.0
Hayfever, allergic rhinitis or eczema	1.2	2.6	2.6	1.6	1.6
Pulse wave Arterial Stiffness index	1.2	1.4	2.7	1.6	-0.4
Age at first live birth	1.2	2.1	2.5	-1.3	-1.6
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.8	-1.7	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.8	-2.0	0.1
Commuting to job workplace: Public transport	1.2	1.4	2.8	1.7	-0.1
Commuting to job workplace: Cycle	1.2	1.5	2.9	-1.7	0.3
Prostate Cancer	1.1	1.6	2.4	1.6	-0.9
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.4	1.8	0.9
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	1.8	1.1	1.3
Diabetes (mother)	1.1	1.3	1.7	-1.3	1.0
Age when periods started (menarche)	1.1	2.8	3.2	-1.8	1.5
Chronic bronchitis/emphysema (father)	1.1	1.2	1.3	-1.1	-1.1
Leg predicted mass (left)	1.1	6.0	8.5	-1.9	-2.9
Impedance of arm (right)	1.1	5.3	10.2	-0.7	3.2
Illnesses of mother	1.1	1.4	2.7	1.6	0.4
Exposure to tobacco smoke at home	1.1	1.2	2.3	-1.5	-0.3
Ever smoked	1.1	2.0	4.0	0.1	2.0
Bipolar Disorder or Schizophrenia	1.0	2.4	2.9	-1.7	1.4
Body Mass Index (BMI) (2010)	1.0	1.4	2.9	0.0	-1.7
Average weekly fortified wine intake	1.0	1.2	1.4	1.2	1.0
Hair/balding pattern: Pattern 2	1.0	1.2	2.4	0.2	1.5
Falls in the last year	1.0	1.4	1.6	-1.1	1.3
Birth weight of first child	1.0	1.9	3.7	-1.9	-0.3
Medication: Ventolin 100micrograms inhaler	1.0	1.2	1.8	0.8	1.4
Health satisfaction	1.0	1.2	2.4	-0.2	-1.6
Emphysema/chronic bronchitis	1.0	1.1	2.2	0.1	1.5
Comparative height size at age 10	1.0	5.4	9.5	-1.1	-3.1
Hearing aid user	1.0	1.1	2.0	-1.4	0.4
Alzheimer’s Disease (including proxy)	0.9	1.3	2.5	-0.1	1.6
Major Depression (MDD)	0.9	1.1	1.8	-0.7	1.3
Medication: Co-codamol	0.9	1.0	1.8	0.5	-1.3
Maternal smoking around birth	0.9	1.2	2.0	-1.4	-0.7
Relative age voice broke	0.9	1.4	1.4	1.1	1.2
Multivitamins +/- minerals	0.9	1.1	1.2	1.1	-1.0
Financial difficulties in last 2 years	0.9	1.2	2.4	1.5	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.0	1.4	-0.4
Impedance of arm (left)	0.9	4.0	7.8	-0.3	2.8
Peak expiratory flow (PEF)	0.9	2.0	3.7	0.6	-1.9
Angina (self-reported)	0.9	1.2	2.2	0.5	1.5
Medication: Allopurinol	0.9	1.2	2.0	1.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	-0.1	1.5
Medication for cholesterol	0.9	1.4	2.6	0.3	1.6
Ever taken oral contraceptive pill	0.9	1.0	2.0	-1.4	-0.4
Financial situation satisfaction	0.9	1.1	1.4	0.9	1.2
Alcohol drinker status: Never	0.9	1.1	2.0	1.4	-0.5
Ulcerative Colitis	0.8	1.2	2.3	-1.5	0.2
Taking other prescription medications	0.8	1.3	1.6	1.3	1.0
Supplements: Glucosamine	0.8	1.0	1.9	1.4	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.4	0.3	-1.5
Breastfed as a baby	0.8	0.9	1.5	0.6	-1.2
Forced vital capacity (FVC), Best measure	0.8	2.9	4.6	-1.1	-2.1
Shortness of breath walking on level ground	0.8	0.9	1.6	1.2	-0.6
Knee pain experienced in last month	0.8	1.3	1.8	-1.3	-0.9
Long-standing illness, disability or infirmity	0.8	1.3	1.5	1.2	1.0
Osteoporosis (self-reported)	0.8	0.9	1.7	1.3	0.5
Number of self-reported non-cancer illnesses	0.8	1.3	2.5	1.6	-0.3
Diastolic blood pressure, automated reading	0.8	2.5	4.9	0.2	-2.2
Alcohol drinker status: Previous	0.8	0.9	1.6	-1.3	-0.3
Alzheimer’s Disease (in mother)	0.7	0.8	1.3	-0.4	1.2
Allergy or Eczema	0.7	1.9	3.6	1.9	0.4
Relative age of first facial hair	0.7	1.4	1.5	1.2	1.2
Impedance of leg (right)	0.7	3.2	5.3	1.0	2.3
Pulse rate	0.7	1.2	2.1	-1.4	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.1	-0.3	1.4
Hair/balding pattern: Pattern 4	0.7	1.7	3.2	0.6	-1.8
Comparative body size at age 10	0.7	1.9	3.8	-1.9	-0.4
Migraine (self-reported)	0.7	0.8	1.7	-1.3	0.1
Chest pain or discomfort	0.7	1.0	1.7	0.6	-1.3
Had major operations	0.7	0.8	1.5	-0.2	1.2
Ever had bowel cancer screening	0.7	0.8	1.1	1.0	-0.7
Breast cancer (self-reported)	0.7	0.9	1.7	1.3	-0.3
Fractured/broken bones in last 5 years	0.7	0.8	1.2	0.7	-1.1
Impedance of whole body	0.7	3.5	7.0	0.1	2.6
Bipolar Disorder (2018)	0.6	0.9	1.7	0.4	1.3
Depression (Nagel 2018)	0.6	0.9	1.6	0.4	1.3
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.3	0.5	-1.8
HDL Cholesterol	0.6	1.0	2.0	-0.1	1.4
Lupus	0.6	0.9	1.0	0.8	1.0
Number of treatments/medications taken	0.6	1.0	1.1	1.0	-0.9
Fed-up feelings	0.6	1.2	1.2	1.1	-1.1
Forced vital capacity (FVC)	0.6	2.1	3.4	-0.9	-1.8
Medication: Simvastatin	0.6	0.9	1.7	1.3	0.1
Alcohol intake versus 10 years previously	0.6	0.9	1.2	-1.1	0.7
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.0	1.0	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.5	0.2	1.2
Suffer from ‘nerves’	0.6	0.9	1.0	0.9	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	-1.2	-0.1
Illnesses of siblings: Diabetes	0.6	0.8	1.0	0.8	-1.0
Commuting to job workplace: Walk	0.6	0.7	1.4	0.2	-1.2
Smoking status: Current	0.6	0.9	1.8	0.1	1.3
Medication: Lisinopril	0.6	0.8	0.9	0.9	-0.9
Pain experienced in last month	0.6	1.0	1.6	0.6	1.3
Basal cell carcinoma (self-reported)	0.6	0.7	0.7	-0.8	0.9
Depressed Affect (Nagel 2018)	0.5	1.0	1.9	-0.3	-1.4
Irritable Bowel Disease (IBD)	0.5	1.2	1.3	-1.1	-1.1
Neuroticism (2016)	0.5	0.8	1.5	-1.2	-0.3
Rheumatoid Arthritis	0.5	0.8	1.0	-1.0	-0.7
Heel T-Score	0.5	4.1	7.1	2.7	1.0
Angina	0.5	0.7	1.1	0.6	1.0
Medication for hormone replacement therapy	0.5	0.6	0.6	-0.7	-0.8
Supplements: Zinc	0.5	0.6	1.1	1.0	0.1
Number of incorrect matches in round	0.5	0.8	1.1	-1.0	0.7
Had other major operations	0.5	0.6	0.9	1.0	0.6
Weight	0.5	2.5	3.1	-1.4	-1.8
Worrier / anxious feelings	0.5	1.0	1.8	-0.3	-1.3
Lung cancer (father)	0.5	0.6	0.9	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	1.8	-1.1	-1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	0.7	0.7	-0.9
Supplements: Vitamin C	0.5	0.5	0.9	0.9	-0.4
Illnesses of father: Heart disease	0.5	0.7	0.8	0.9	0.8
Loneliness, isolation	0.5	0.7	0.8	-0.7	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	-0.2	1.1
Average weekly champagne plus white wine intake	0.5	0.7	1.3	0.0	1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.2	-0.0	1.1
Medication: Atorvastatin	0.5	0.7	0.8	0.9	0.7
Unable to work because of sickness or disability	0.5	0.7	1.0	-0.7	1.0
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.9	-0.0	1.7
Pack years of smoking	0.5	0.7	1.1	-1.0	-0.6
Vitamin and mineral supplements	0.4	0.5	0.6	-0.7	0.7
Diabetes (father)	0.4	0.5	0.9	-0.2	-1.0
Pack years adult smoking proportion	0.4	0.6	1.0	-1.0	-0.5
High blood pressure	0.4	1.2	2.3	0.3	-1.5
High blood pressure (mother)	0.4	0.5	0.9	0.4	0.9
Impedance of leg (left)	0.4	2.1	3.8	0.5	2.0
Had menopause	0.4	0.5	0.9	0.2	1.0
Medication: Ramipril	0.4	0.5	0.5	-0.7	-0.7
Hip circumference	0.4	1.9	2.5	-1.1	-1.6
Happiness	0.4	0.5	0.9	0.2	1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.9	-0.9	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	0.1	0.9
Neck or shoulder pain in last month	0.4	0.6	0.7	-0.8	-0.7
Heart disease (mother)	0.4	0.4	0.7	-0.4	-0.8
Leg pain on walking	0.4	0.5	0.7	0.5	-0.8
Medication: Aspirin	0.4	0.5	1.0	-0.3	-1.0
Mood swings	0.4	0.8	1.2	-0.6	-1.1
Medication: Aspirin	0.4	0.5	0.9	-0.1	-1.0
Miserableness	0.4	0.7	1.4	0.0	-1.2
Medication: Blood pressure	0.4	0.7	1.4	-0.2	-1.2
Number of operations (self-reported)	0.4	0.6	0.7	0.7	0.8
Risk taking	0.4	0.6	0.7	0.7	0.8
Cholesterol lowering medication	0.4	0.6	0.7	0.8	0.8
Coronary Artery Disease (CAD)	0.3	0.4	0.7	0.8	-0.1
Blood Eosinophil Count	0.3	1.9	3.9	2.0	0.1
Blood Platelet Count	0.3	3.6	6.5	0.9	-2.5
Waist Hip Ratio (WHR)	0.3	1.5	3.0	-0.0	1.7
Neuroticism	0.3	0.8	1.5	-0.3	-1.2
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.6	0.8	0.5
Systolic blood pressure, automated reading	0.3	1.0	1.9	0.2	-1.4
Current tobacco smoking	0.3	0.5	1.1	-0.1	1.0
Qualifications: CSEs or equivalent	0.3	0.4	0.8	0.1	0.9
Stomach or abdominal pain in last month	0.3	0.4	0.5	0.5	0.7
Nervous feelings	0.3	0.5	1.0	-1.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	-0.9	0.0
Neuroticism score	0.3	0.6	1.1	-0.4	-1.1
Arm fat percentage (right)	0.3	1.2	2.1	-0.6	1.5
Time employed in main current job	0.3	0.4	0.8	0.0	0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.6	-0.6	-1.3
Noisy workplace	0.3	0.4	0.8	-0.9	0.1
Depression (self-reported)	0.3	0.3	0.5	0.7	-0.3
Headache pain in last month	0.3	0.5	0.9	-0.4	-0.9
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.9	0.2
Number of full brothers	0.3	0.4	0.8	0.9	0.1
Qualifications: College or University degree	0.3	0.8	1.1	-0.7	-1.1
Medication: Blood pressure	0.3	0.5	0.6	0.7	-0.8
Mean time to correctly identify matches	0.3	0.5	0.7	-0.5	-0.8
Hypertension (Self-reported)	0.3	0.8	1.5	0.2	-1.2
High cholesterol (Self-reported)	0.3	0.5	1.0	1.0	-0.2
Age started oral contraceptive pill	0.3	0.3	0.5	-0.4	-0.7
Ever depressed for a whole week	0.3	0.4	0.6	0.8	0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.5	0.6	0.8	-0.5
Reaction Time	0.2	0.3	0.5	-0.3	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.6	0.7	-0.8
Triglycerides	0.2	0.3	0.5	-0.7	-0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.3	-0.6	-0.4
Systolic Blood Pressure	0.2	1.2	2.2	0.4	-1.5
Chronotype (morning person)	0.2	0.4	0.7	-0.8	-0.1
Hearing difficulty/problems: Yes	0.2	0.2	0.3	-0.5	-0.5
Trunk fat percentage	0.2	0.7	0.9	-0.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.3	0.7
Medication: Levothyroxine sodium	0.2	0.3	0.4	-0.4	-0.7
Alcohol usually taken with meals	0.2	0.4	0.7	0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	1.0	0.0
Qualifications: None of the above	0.2	0.4	0.8	-0.0	0.9
Father’s age at death	0.2	0.2	0.3	0.6	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	0.9	0.3
Medication: Cholesterol lowering	0.2	0.3	0.5	0.2	-0.7
Tense / ‘highly strung’	0.2	0.3	0.6	0.1	0.8
Leg fat percentage (right)	0.2	0.6	1.0	0.5	1.0
Alcohol intake frequency.	0.2	0.4	0.6	-0.8	0.5
Number of full sisters	0.2	0.2	0.2	-0.5	-0.4
Overall health rating	0.2	0.5	0.9	0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.2	0.6
Arm fat percentage (left)	0.2	0.9	1.6	-0.4	1.3
Medication: Bendroflumethiazide	0.2	0.4	0.4	0.6	-0.6
Irritability	0.2	0.3	0.5	0.7	0.2
Supplements: Calcium	0.2	0.3	0.5	-0.1	-0.7
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.2	-0.6
Age at First Birth	0.1	0.2	0.2	0.4	-0.4
Bipolar Disorder (2011)	0.1	0.1	0.2	0.0	0.4
Mean Putamen Volume	0.1	0.2	0.3	0.5	0.2
Fasting Glucose	0.1	0.1	0.2	-0.3	0.4
Primary Biliary Cirrhosis	0.1	0.1	0.1	-0.4	-0.3
BMI	0.1	0.7	1.4	-1.2	-0.3
Cardiovascular Disease	0.1	0.3	0.4	0.7	-0.3
Tanning	0.1	1.5	1.9	1.1	1.4
Ever had hysterectomy (womb removed)	0.1	0.2	0.3	-0.0	0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.0	-0.4
Severe depression (siblings)	0.1	0.1	0.3	0.5	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.1	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.2	0.5	-0.2
Medication: Atenolol	0.1	0.2	0.3	0.3	0.5
Trunk fat mass	0.1	0.6	1.1	-1.1	-0.3
Mouth/teeth dental problems	0.1	0.1	0.2	-0.4	-0.2
Heart attack	0.1	0.2	0.2	0.5	-0.3
Pain all over the body in last month	0.1	0.1	0.2	0.4	0.1
Fluid intelligence score	0.1	0.3	0.5	0.2	-0.7
Illnesses of siblings	0.1	0.1	0.2	-0.5	0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	-0.0	-0.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.2	0.4
Prospective memory result	0.1	0.1	0.2	-0.5	-0.1
Arm fat mass (right)	0.1	0.6	1.2	-1.1	0.1
Length of working week for main job	0.1	0.1	0.2	0.3	0.4
Body fat percentage	0.1	0.5	0.9	-0.3	1.0
Medication for pain relief, constipation, heartburn	0.1	0.1	0.1	0.4	0.2
Medication: Omeprazole	0.1	0.2	0.2	0.5	0.3
Whole body fat mass	0.1	0.5	0.9	-1.0	-0.2
Age at last live birth	0.1	0.2	0.4	-0.6	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.0	0.4
Friendships satisfaction	0.1	0.1	0.1	0.4	-0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.2	-0.4
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.2	-0.5
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.5	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.6	-0.1	-0.8
Arm fat mass (left)	0.1	0.5	0.9	-0.9	0.2
Wears glasses or contact lenses	0.1	0.1	0.1	0.3	0.3
Mother’s age at death	0.1	0.1	0.2	0.0	0.4
Illnesses of father: High blood pressure	0.1	0.2	0.2	-0.4	0.3
Leg fat percentage (left)	0.1	0.2	0.5	0.1	0.7
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.2	0.4
Myopia	0.1	0.1	0.2	-0.2	0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	0.3	0.3
Worry (Nagel 2018)	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.3	0.1
Hypothyroidism (self reported)	0.0	0.1	0.1	-0.2	0.3
Lung FEV1/FVC ratio	0.0	0.1	0.1	-0.3	0.2
Lung FVC	0.0	0.2	0.3	0.6	-0.3
Hair Pigment	0.0	0.8	1.5	-0.3	-1.2
Sensitivity / hurt feelings	0.0	0.1	0.1	0.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	-0.1	0.2
Body mass index (BMI)	0.0	0.0	0.1	-0.3	0.0
Waist circumference	0.0	0.1	0.2	-0.5	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.1	0.1	-0.1	0.3
Medication: Lansoprazole	0.0	0.0	0.1	0.0	-0.2
Medication: Paracetamol	0.0	0.1	0.1	-0.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	0.2	-0.3
High blood pressure (siblings)	0.0	0.1	0.1	0.1	0.4
Eye problems/disorders: None of the above	0.0	0.0	0.0	-0.2	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.2	0.1
Medication: Ibuprofen	0.0	0.0	0.0	-0.2	0.0
Leg fat mass (right)	0.0	0.0	0.0	-0.2	-0.0
Guilty feelings	0.0	0.0	0.0	0.1	-0.1
Medication: Paracetamol	0.0	0.0	0.0	0.2	0.1
Leg fat mass (left)	0.0	0.1	0.2	-0.4	-0.2

Hub : Genes

PARD6B

Models

Trait associations