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chr20:41,844,745-45,456,440

Best TWAS P=2.35e-16 · Best GWAS P=7.77e-23 conditioned to 6.58e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	TOX2	0.38	0.12	lasso	6	0.39	2.3e-21	5.2	5.5	3.5e-08	-0.01	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	NEURL2	0.20	0.06	lasso	3	0.06	4.2e-04	-8.0	6.6	5.0e-11	-0.13	0.05	0.71	FALSE
3	GTEx	Adrenal Gland	PABPC1L	0.32	0.07	lasso	8	0.07	1.9e-03	3.4	-7.7	2.1e-14	-0.43	0.05	0.74	TRUE
4	GTEx	Artery Coronary	PLTP	0.34	0.07	lasso	5	0.10	2.6e-04	-8.3	5.8	5.2e-09	-0.04	0.06	0.51	FALSE
5	GTEx	Brain Cerebellar Hemisphere	CTSA	0.18	0.02	lasso	5	0.00	4.0e-01	-6.5	5.8	7.7e-09	0.02	0.15	0.39	FALSE
6	GTEx	Brain Cerebellar Hemisphere	SNX21	0.41	0.09	enet	16	0.05	2.1e-02	-5.7	-6.2	6.0e-10	-0.04	0.04	0.59	FALSE
7	GTEx	Brain Cerebellar Hemisphere	RP3-337O18.9	0.18	0.00	lasso	5	0.00	4.0e-01	-7.9	7.0	3.0e-12	-0.01	0.08	0.48	FALSE
8	GTEx	Brain Cerebellum	CTSA	0.20	0.12	lasso	4	0.11	3.7e-04	-6.5	6.5	8.7e-11	-0.01	0.31	0.08	FALSE
9	GTEx	Brain Cerebellum	RP3-337O18.9	0.14	0.11	lasso	3	0.10	9.4e-04	-6.5	6.5	8.7e-11	-0.01	0.28	0.19	FALSE
10	GTEx	Brain Cortex	CD40	0.36	-0.01	enet	50	-0.01	5.1e-01	-4.6	5.4	5.3e-08	-0.05	0.06	0.16	FALSE
11	GTEx	Breast Mammary Tissue	DNTTIP1	0.13	0.07	lasso	4	0.08	7.3e-05	-5.6	5.2	2.2e-07	0.00	0.83	0.05	FALSE
12	GTEx	Colon Sigmoid	ZSWIM1	0.28	0.13	lasso	2	0.14	1.8e-05	-6.4	-6.4	1.3e-10	0.01	0.64	0.12	FALSE
13	GTEx	Esophagus Mucosa	SNX21	0.07	0.09	lasso	4	0.06	4.1e-05	-5.7	6.2	5.9e-10	0.01	0.92	0.00	FALSE
14	GTEx	Esophagus Muscularis	DNTTIP1	0.17	0.14	lasso	5	0.14	6.3e-09	-5.2	5.6	2.5e-08	0.02	1.00	0.00	FALSE
15	GTEx	Heart Atrial Appendage	DNTTIP1	0.09	0.10	lasso	2	0.08	1.6e-04	-6.5	6.2	5.4e-10	0.00	0.78	0.01	FALSE
16	GTEx	Liver	DNTTIP1	0.24	0.06	lasso	4	0.13	1.8e-04	-5.2	6.1	1.4e-09	0.00	0.06	0.79	FALSE
17	GTEx	Muscle Skeletal	SNX21	0.15	0.09	lasso	6	0.08	5.8e-08	-5.2	-5.5	4.1e-08	-0.02	1.00	0.00	FALSE
18	GTEx	Nerve Tibial	PLTP	0.11	0.01	enet	27	0.01	4.6e-02	-6.6	6.3	2.4e-10	-0.06	0.02	0.89	FALSE
19	GTEx	Nerve Tibial	TOX2	0.64	0.53	lasso	14	0.60	5.5e-53	5.2	5.8	5.8e-09	-0.05	1.00	0.00	TRUE
20	GTEx	Skin Sun Exposed Lower leg	CTSA	0.11	0.04	lasso	4	0.02	4.1e-03	-6.6	5.8	6.8e-09	-0.02	0.75	0.01	FALSE
21	GTEx	Skin Sun Exposed Lower leg	RP3-337O18.9	0.08	0.03	lasso	6	0.02	1.2e-02	-6.6	5.9	4.6e-09	0.01	0.30	0.03	FALSE
22	GTEx	Testis	TOX2	0.20	0.09	lasso	2	0.04	8.6e-03	5.0	5.1	2.8e-07	-0.09	0.11	0.06	FALSE
23	GTEx	Testis	OSER1	0.26	0.13	lasso	4	0.23	2.0e-10	-6.2	-6.5	8.1e-11	-0.08	0.99	0.00	TRUE
24	GTEx	Testis	ZSWIM1	0.23	0.11	lasso	7	0.12	6.0e-06	-6.6	-6.9	4.5e-12	0.02	0.80	0.03	FALSE
25	GTEx	Thyroid	SNX21	0.09	0.10	lasso	3	0.10	3.0e-08	-6.7	6.9	4.9e-12	-0.04	0.99	0.00	FALSE
26	GTEx	Whole Blood	SNX21	0.08	0.01	lasso	2	0.00	5.2e-01	5.8	-5.3	1.1e-07	0.06	0.09	0.06	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	CTSA	0.15	0.06	enet	20	0.12	7.7e-15	-8.3	6.3	3.5e-10	-0.09	0.13	0.87	FALSE
28	YFS	Blood	CTSA	0.03	0.02	lasso	5	0.01	4.1e-04	-6.6	5.9	3.0e-09	0.01	0.86	0.00	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC12A5	0.07	0.03	lasso	2	0.03	2.0e-06	-5.3	-5.4	5.7e-08	-0.04	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZSWIM1	0.01	0.01	blup	41	0.01	2.4e-02	-6.4	-5.8	5.0e-09	0.01	0.28	0.02	FALSE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ZSWIM1	0.06	0.02	blup	42	0.04	5.8e-03	-6.5	-6.2	6.6e-10	0.02	0.06	0.05	FALSE
32	The Cancer Genome Atlas	Glioblastoma Multiforme	MMP9	0.25	0.16	enet	6	0.16	1.2e-05	-5.7	6.5	1.0e-10	0.04	0.03	0.39	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZSWIM1	0.04	0.01	blup	42	0.03	2.1e-04	-6.5	-7.5	5.4e-14	0.04	0.30	0.16	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZSWIM1	0.13	0.00	enet	21	0.02	2.7e-02	-6.7	-5.4	7.2e-08	-0.03	0.02	0.08	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZSWIM1	0.04	0.07	lasso	4	0.07	3.1e-08	-6.6	-6.8	8.4e-12	0.01	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC12A5	0.09	0.04	lasso	1	0.03	6.3e-05	-5.3	-5.3	1.1e-07	-0.04	0.02	0.96	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	ZSWIM1	0.04	0.01	blup	41	0.01	9.5e-03	-9.1	-8.2	2.4e-16	0.04	0.00	0.82	TRUE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DNTTIP1	0.06	0.04	enet	4	0.04	6.7e-03	-5.1	5.3	1.2e-07	0.04	0.06	0.28	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PLTP	0.34	0.00	lasso	3	0.05	2.8e-03	-8.0	6.2	4.9e-10	-0.07	0.01	0.28	FALSE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SLC12A5	0.17	0.05	lasso	6	0.06	1.1e-03	5.5	-5.8	9.1e-09	-0.09	0.01	0.57	TRUE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZSWIM1	0.04	0.07	blup	41	0.05	4.3e-06	-6.5	-7.6	2.8e-14	0.04	0.99	0.01	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZSWIM3	0.02	0.03	lasso	2	0.02	1.7e-03	-6.5	-6.5	6.9e-11	0.01	0.12	0.04	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	C20orf111	0.08	0.06	lasso	3	0.04	4.9e-05	-5.2	-5.4	8.5e-08	-0.08	0.28	0.46	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	SNX21	0.07	0.00	blup	46	0.03	1.1e-03	-6.8	6.1	8.1e-10	-0.02	0.01	0.91	FALSE