TWAS hub - PTPN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.112	0.0440	0.0083	-0.004	NA	-0.004	NA	-0.002	8.7e-01	NA	8.2e-01	NA	4.5e-01
2	GTEx	Nerve Tibial	0.109	0.0441	0.0047	0.013	NA	0.007	NA	0.011	3.8e-02	NA	1.0e-01	NA	5.4e-02
3	YFS	Blood	0.372	0.0342	0.0000	0.301	0.244	0.304	0.295	0.303	3.0e-100	7e-79	1.1e-101	4.2e-98	2.5e-101

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Illness, injury, bereavement, stress in last 2 years	3.9	4.8	13.6	0.5	-0.6	-3.7
Average weekly beer plus cider intake	3.8	5.5	11.7	-1.0	-3.4	2.0
Hair/balding pattern: Pattern 3	3.7	5.5	7.1	-2.7	2.6	1.7
Mouth/teeth dental problems: Dentures	3.7	6.3	8.7	-2.7	-1.7	3.0
Medication: Atenolol	3.6	4.5	9.0	0.4	-3.0	-2.1
Unable to work because of sickness or disability	3.6	4.6	13.7	0.4	-3.7	0.2
Commuting to job workplace: Walk	3.2	3.4	7.3	0.9	1.4	-2.7
Blood Red Count	3.1	30.2	48.4	-7.0	6.4	-1.3
Smoking Status	3.1	7.5	17.6	-0.5	-2.2	4.2
Qualifications: A levels/AS levels or equivalent	3.0	6.7	10.1	-0.8	3.2	-3.1
Hand grip strength (left)	2.8	7.3	9.4	2.5	2.4	-3.1
Major Depression (MDD)	2.7	3.3	5.5	1.1	-2.3	-1.8
Hand grip strength (right)	2.7	7.4	8.9	2.6	2.6	-3.0
Sitting height	2.6	18.2	50.0	-2.0	0.8	-7.1
Qualifications: None of the above	2.6	5.6	9.2	1.8	-3.0	2.1
Mouth/teeth dental problems	2.6	3.9	6.2	2.5	1.3	-2.0
Exposure to tobacco smoke at home	2.5	2.8	6.7	-1.3	0.4	2.6
Medication: Bendroflumethiazide	2.5	3.8	8.5	1.5	-2.9	-0.9
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	5.0	2.2	0.1	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	5.3	-2.3	-1.8	-0.0
Family relationship satisfaction	2.3	2.9	4.2	-2.1	-1.4	1.5
Ever had bowel cancer screening	2.3	2.7	6.9	-0.9	2.6	-0.4
Crohns Disease (2012)	2.2	3.6	9.1	1.3	3.0	0.1
Alcohol usually taken with meals	2.2	3.6	8.9	-0.5	1.3	-3.0
Exposure to tobacco smoke outside home	2.2	2.9	6.0	-1.6	-0.4	2.5
Friendships satisfaction	2.2	2.8	7.0	-2.6	0.9	0.6
Wheeze or whistling in the chest in last year	2.1	3.7	8.2	0.6	-1.7	2.9
Health satisfaction	2.1	2.7	5.9	-2.4	1.2	-0.7
Medication: Seretide 50 evohaler	2.1	2.5	5.9	1.0	-2.4	0.7
Smoking status: Current	2.1	3.4	10.1	0.3	-0.0	3.2
Ever had prostate specific antigen (PSA) test	2.1	2.4	3.1	-1.5	1.4	1.8
Hypothyroidism (self reported)	2.0	4.5	9.3	-0.6	-2.0	-3.1
Hearing difficulty/problems with background noise	2.0	3.2	5.2	-2.3	-1.5	1.4
Hair/balding pattern: Pattern 2	2.0	2.5	4.6	0.8	-2.1	1.5
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	7.8	-2.8	0.6	1.1
Alzheimer’s Disease (in mother)	1.9	2.2	4.3	2.1	1.3	-0.9
Crohns Disease (2017)	1.9	4.3	12.1	-0.9	3.5	-0.1
Height	1.9	36.5	94.7	1.2	3.7	-9.7
Current tobacco smoking	1.9	3.1	9.0	0.4	-0.2	3.0
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	7.5	2.7	-1.3	0.6
Loud music exposure frequency	1.9	2.1	3.8	1.2	1.0	1.9
Headache pain in last month	1.9	3.3	8.2	0.8	-1.0	-2.9
Qualifications: College or University degree	1.9	6.0	9.1	-0.6	2.9	-3.0
Commuting to job workplace: Car/motor vehicle	1.9	2.1	3.7	-0.3	-1.9	1.6
Tinnitus: Yes, now most or all of the time	1.9	2.2	3.1	-1.8	1.1	1.6
Illnesses of mother	1.8	2.2	6.5	-2.5	-0.1	-0.1
Standing height	1.8	17.6	46.0	-0.1	2.6	-6.8
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	6.5	-1.4	2.5	-0.4
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	8.4	0.2	-1.4	-2.9
Smoking status: Previous	1.8	2.7	4.0	-1.9	-2.0	0.7
Qualifications: nursing, teaching	1.8	2.9	5.2	-0.6	2.3	-1.8
Medication: Lisinopril	1.8	2.4	3.0	1.2	-1.7	-1.7
Age started oral contraceptive pill	1.8	2.3	6.8	0.2	-0.1	-2.6
Type 2 Diabetes (T2D) (2012)	1.7	1.9	5.7	-0.0	2.4	-0.2
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	2.6	0.8	1.6	-1.5
Pulse wave peak to peak time	1.7	2.0	3.6	-1.3	-0.9	-1.9
Comparative height size at age 10	1.7	9.3	20.3	-1.6	2.2	-4.5
Osteoarthritis (self-reported)	1.7	2.2	3.7	-1.9	0.2	1.7
Mother’s age at death	1.7	2.1	5.8	0.1	2.4	-0.7
Blood Eosinophil Count	1.6	11.9	26.4	2.7	-5.1	1.5
Heel T-Score	1.6	12.6	32.8	-1.6	1.6	5.7
Relative age voice broke	1.6	2.4	5.0	0.8	1.2	2.2
Past tobacco smoking	1.6	2.9	3.9	2.0	1.2	-1.9
Pain all over the body in last month	1.6	1.7	4.4	-0.2	-0.8	2.1
Comparative body size at age 10	1.6	4.4	6.8	-2.6	0.6	2.4
Back pain experienced in last month	1.6	2.4	4.4	0.1	-1.7	2.1
Osteoporosis (self-reported)	1.6	2.0	3.3	1.5	-1.8	-0.6
Myopia	1.6	2.3	6.8	2.6	-0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.9	-0.9	-1.1	2.0
Alcohol drinker status: Previous	1.6	1.9	5.1	-0.2	-2.3	-0.7
Intelligence (Savage-Jansen 2018)	1.5	4.7	10.0	-0.6	1.9	-3.2
Alzheimer’s Disease (including proxy)	1.5	2.2	4.9	2.2	1.2	-0.1
Irritable Bowel Disease (IBD)	1.5	3.5	7.6	-1.4	2.8	0.9
Hearing difficulty/problems: Yes	1.5	2.3	3.4	-1.4	-1.8	1.2
Father’s age at death	1.5	2.0	5.3	-2.3	-0.3	0.8
Pulse wave Arterial Stiffness index	1.5	1.8	2.9	1.7	0.8	1.3
High blood pressure (siblings)	1.5	2.2	3.5	1.9	-1.6	0.7
Mouth/teeth dental problems: Loose teeth	1.5	1.8	5.0	-2.2	0.2	0.6
Illnesses of father: Heart disease	1.5	2.1	4.7	-2.2	-0.5	1.2
Loneliness, isolation	1.5	2.1	5.1	1.0	0.2	2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.0	1.3	1.4	1.0
Alcohol drinker status: Never	1.5	1.8	3.1	0.9	1.8	-1.2
Medication: Paracetamol	1.4	2.3	4.2	2.0	0.2	-1.6
Number of children fathered	1.4	1.6	3.0	-0.7	1.1	1.7
Mood swings	1.4	2.5	5.9	1.0	-2.4	0.7
Schizophrenia vs Biploar Disorder	1.3	1.7	4.8	-2.2	0.4	0.1
Severe depression (siblings)	1.3	1.5	1.6	1.3	1.3	1.1
Medication: Levothyroxine sodium	1.3	2.3	5.5	-0.8	-0.8	-2.4
Had other major operations	1.3	1.6	2.5	-1.6	1.2	-1.0
Medication: Cholesterol lowering	1.3	2.0	3.3	1.3	-1.0	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	7.8	0.4	-0.1	-2.8
Hearing aid user	1.3	1.5	2.4	-0.5	-1.6	1.4
Type 2 Diabetes (T2D) (2018)	1.2	2.2	2.7	1.2	1.6	-1.5
Allergy	1.2	2.7	4.5	-2.1	-0.6	-1.8
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.1	-0.3	1.4	1.5
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.6	0.8	-1.6	1.1
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.5	0.9	-1.9	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.3	2.5	-1.6	1.2	0.3
Medication: Ibuprofen	1.2	1.5	2.9	1.7	-1.2	0.3
Had major operations	1.2	1.4	4.0	0.1	-0.2	2.0
Arm fat percentage (left)	1.2	4.7	7.2	-0.7	-2.5	2.7
Commuting to job workplace: Public transport	1.2	1.4	4.1	0.1	2.0	0.1
Ever depressed for a whole week	1.2	1.4	2.3	1.4	0.1	1.5
Verbal and Numeric Reasoning (VNR)	1.1	2.7	4.1	-1.0	1.7	-2.0
Age when periods started (menarche)	1.1	2.7	4.0	1.6	-1.3	2.0
Serious illness, injury or assault to yourself	1.1	1.3	3.0	0.9	0.2	1.7
Multivitamins +/- minerals	1.1	1.4	2.7	-0.2	1.7	-1.2
Supplements: Glucosamine	1.1	1.4	3.7	-0.6	1.9	-0.3
Medication: Ramipril	1.1	1.5	3.8	0.5	0.6	-1.9
Arm fat percentage (right)	1.1	4.5	8.1	-0.4	-2.3	2.8
Peak expiratory flow (PEF)	1.1	2.5	4.5	0.2	-1.8	-2.1
Gout (self-reported)	1.1	1.5	2.5	-0.3	-1.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	5.4	-1.1	-0.7	-2.3
Illnesses of father: None of the above (group 1)	1.1	1.4	3.6	1.9	0.6	-0.3
Illnesses of father: High blood pressure	1.1	1.3	2.3	-1.5	-0.3	1.2
Age at First Birth	1.0	1.4	3.2	1.8	0.9	-0.3
HbA1C	1.0	1.1	1.7	-1.3	-0.9	0.8
Allergy or Eczema	1.0	2.6	7.8	2.8	-0.0	-0.0
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.7	-1.3	-1.3	0.4
Vitamin and mineral supplements	1.0	1.3	2.7	-0.5	-1.6	1.0
Maternal smoking around birth	1.0	1.4	4.0	0.0	0.5	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	1.6	1.3	-1.2	1.1
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	9.6	0.1	-0.4	-3.1
Happiness	1.0	1.2	3.3	-1.8	0.5	0.0
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.9	1.7	-0.6	0.8
Breastfed as a baby	1.0	1.2	2.1	-1.5	-1.0	0.7
Birth weight	1.0	2.1	4.1	2.0	-1.3	-0.7
Emphysema/chronic bronchitis	1.0	1.2	1.7	-1.2	-0.6	1.3
Medication: Blood pressure	1.0	1.7	1.8	1.3	-1.2	-1.3
Medication: Aspirin	1.0	1.3	3.8	0.2	0.0	-2.0
Depression (Nagel 2018)	0.9	1.4	2.7	1.1	-1.6	0.3
Blood Platelet Count	0.9	10.3	18.0	0.2	4.2	3.6
Number of treatments/medications taken	0.9	1.7	2.9	0.5	-1.7	-1.4
Diabetes (mother)	0.9	1.1	2.5	0.3	-0.9	-1.6
Trunk fat percentage	0.9	3.6	7.0	-0.5	-2.6	1.9
Townsend deprivation index at recruitment	0.9	1.2	3.0	-0.7	-0.4	1.7
Body mass index (BMI)	0.9	3.9	7.8	-0.1	-2.8	1.9
Forced vital capacity (FVC)	0.9	3.6	10.5	-0.3	0.3	-3.2
Body fat percentage	0.9	3.5	5.2	-0.6	-2.3	2.2
Eye problems/disorders: None of the above	0.9	1.1	2.9	-0.2	-1.7	-0.5
Medication: Omeprazole	0.9	1.1	1.9	-1.0	-0.5	1.4
Alcohol intake frequency.	0.9	2.0	3.0	1.4	-1.7	-1.1
Number of full sisters	0.9	1.2	3.1	1.8	0.3	-0.5
High cholesterol (Self-reported)	0.9	1.6	2.4	1.1	-1.1	-1.5
Ever smoked	0.9	1.5	3.0	-1.1	-0.6	1.7
Leg fat percentage (left)	0.9	3.2	5.9	-0.4	-1.9	2.4
Pack years of smoking	0.9	1.3	3.6	0.6	0.0	1.9
Alzheimer’s Disease (in father)	0.8	0.8	1.3	0.9	0.7	1.2
Prostate Cancer	0.8	1.1	2.0	1.4	1.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.8	1.1	1.3	-0.9	1.1	-1.1
Taking other prescription medications	0.8	1.2	1.7	1.2	-1.3	0.6
Qualifications: CSEs or equivalent	0.8	1.0	1.9	0.6	-1.4	0.9
Financial difficulties in last 2 years	0.8	1.1	2.2	0.2	-1.0	1.5
Heart attack	0.8	1.0	2.1	1.4	-0.8	-0.6
Trunk fat-free mass	0.8	4.6	13.8	0.0	0.3	-3.7
Time employed in main current job	0.8	1.0	2.0	1.4	0.8	0.5
Trunk predicted mass	0.8	4.8	14.1	0.1	0.5	-3.8
Pulse wave reflection index	0.8	0.9	2.2	0.7	-0.3	1.5
Medication: Amlodipine	0.8	1.1	2.4	1.5	0.3	0.9
Forced vital capacity (FVC), Best measure	0.8	3.1	8.1	-0.4	0.9	-2.9
Leg fat percentage (right)	0.8	2.9	5.6	-0.6	-1.7	2.4
Angina (self-reported)	0.8	1.0	3.1	-0.0	-1.8	-0.1
Suffer from ‘nerves’	0.8	1.2	1.9	0.4	-1.2	-1.4
Medication: Aspirin	0.8	1.1	2.8	0.5	0.3	-1.7
Asthma (self-reported)	0.8	1.5	2.6	1.4	-0.4	1.6
Guilty feelings	0.8	1.2	2.2	-0.3	1.5	1.2
Ever taken oral contraceptive pill	0.8	0.9	1.5	0.4	-1.2	-1.1
Risk taking	0.8	1.1	2.6	0.8	-0.2	1.6
Basal cell carcinoma (self-reported)	0.8	1.0	2.1	-0.9	-1.4	-0.3
Rheumatoid Arthritis	0.7	0.9	1.6	-1.2	-0.2	1.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.0	1.4	-1.0	0.3
Relative age of first facial hair	0.7	1.3	2.6	0.5	1.6	1.1
Pack years adult smoking proportion	0.7	1.1	2.3	0.8	-0.5	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.8	-1.3	0.4	1.7
Alcohol intake versus 10 years previously	0.7	1.0	2.1	0.8	-1.4	-0.5
Asthma	0.7	1.3	2.2	1.5	0.1	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	6.3	0.0	0.3	-2.5
Overall health rating	0.7	1.6	3.1	1.2	-1.8	0.5
Eye problems/disorders: Cataract	0.7	0.8	2.0	1.4	0.0	0.5
Breast cancer (self-reported)	0.7	0.9	2.2	-0.7	-1.5	-0.0
Arm fat mass (left)	0.7	2.7	5.9	-0.4	-2.4	1.4
Average weekly champagne plus white wine intake	0.7	1.0	1.6	-1.1	1.3	-0.5
Medication: Paracetamol	0.7	1.1	2.1	1.5	0.3	-1.0
Number of operations (self-reported)	0.7	1.1	2.6	-0.7	-0.2	1.6
Pain experienced in last month	0.7	1.1	2.4	-0.7	0.7	-1.5
Depressed Affect (Nagel 2018)	0.6	1.2	2.0	1.1	-1.4	0.8
Schizophrenia (2018)	0.6	1.2	2.1	-1.5	-0.3	1.2
LDL Cholesterol	0.6	1.0	1.4	0.4	1.2	1.2
Ulcerative Colitis	0.6	0.8	1.4	-1.2	-0.9	0.5
Cardiovascular Disease	0.6	1.9	5.1	2.3	-0.2	-0.7
Medication for hormone replacement therapy	0.6	0.6	1.8	-1.3	0.3	0.1
Medication: Metformin	0.6	0.8	2.0	0.6	-0.3	-1.4
Fed-up feelings	0.6	1.1	2.3	1.5	0.3	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	0.8	1.2	-0.1
Chronic bronchitis/emphysema (father)	0.6	0.7	1.5	-0.7	-1.2	0.2
High blood pressure (mother)	0.6	0.9	1.5	1.1	-1.2	0.3
Had menopause	0.6	0.7	0.9	1.0	0.9	-0.8
Diabetes (self-reported)	0.6	0.9	2.2	0.0	0.8	-1.5
Arm fat mass (right)	0.6	2.6	5.7	-0.3	-2.4	1.4
Tense / ‘highly strung’	0.6	1.0	2.1	-0.9	-1.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	2.4	-0.8	0.3	1.6
Arm fat-free mass (right)	0.6	3.1	9.2	-0.3	-0.2	-3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.5	0.0	0.2	1.6
Age at first live birth	0.6	1.0	1.8	1.1	0.3	-1.3
Medication for pain relief, constipation, heartburn	0.6	1.0	1.4	-1.2	1.0	0.8
Medication: Allopurinol	0.6	0.8	1.5	-0.4	-1.2	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.7	-0.5	-0.6	1.3
Arm predicted mass (right)	0.6	3.1	9.2	-0.1	-0.3	-3.0
Whole body fat-free mass	0.6	3.3	9.9	-0.0	-0.2	-3.1
Medication: Gliclazide	0.6	0.7	1.5	0.3	-0.7	-1.2
Whole body water mass	0.6	3.2	9.4	-0.1	-0.3	-3.1
Medication: Blood pressure	0.6	1.1	2.7	1.7	-0.5	0.5
Irritability	0.6	1.0	2.5	-1.6	0.1	0.7
Fractured/broken bones in last 5 years	0.6	0.7	1.5	-1.2	-0.8	0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.7	1.3	-0.8	-0.2
Ulcerative Colitis (UC)	0.5	0.9	2.2	-0.2	0.7	1.5
Ovarian Cancer	0.5	0.7	1.9	0.4	0.3	1.4
Body Mass Index (BMI) (2010)	0.5	0.7	1.6	-1.3	-0.6	0.4
Waist Hip Ratio (WHR)	0.5	2.2	3.8	1.9	-1.4	-1.0
Angina	0.5	0.7	2.0	-0.3	-1.4	0.0
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.7	1.6	0.4	0.6
Trunk fat mass	0.5	1.9	4.9	-0.6	-2.2	0.8
Number of incorrect matches in round	0.5	0.9	2.3	-0.6	-0.1	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.0	-0.3	-1.4	0.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	1.3	-0.4	0.3
Fluid intelligence score	0.5	1.0	1.5	-1.1	0.7	-1.2
Depression (self-reported)	0.5	0.6	1.2	1.1	0.5	-0.4
Medication: Lansoprazole	0.5	0.5	0.9	1.0	-0.8	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	0.9	0.9	-0.6	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.5	-0.3	-1.2	0.4
Whole body fat mass	0.5	2.0	5.2	-0.6	-2.3	0.7
Age at last live birth	0.5	0.7	1.2	1.1	0.3	-0.9
Leg pain on walking	0.5	0.7	1.9	-1.4	0.1	0.3
Knee pain experienced in last month	0.5	0.7	1.6	0.2	-1.3	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.4	-0.3	-1.2	0.5
Diabetes diagnosed by doctor	0.5	0.9	2.1	-0.0	0.8	-1.5
Arm fat-free mass (left)	0.5	2.6	7.5	0.0	-0.6	-2.7
Commuting to job workplace: Cycle	0.5	0.6	1.2	0.2	-0.6	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.0	0.4	1.0	-0.9
Arm predicted mass (left)	0.5	2.8	8.3	-0.1	-0.2	-2.9
Worry (Nagel 2018)	0.4	0.8	2.1	0.4	-1.5	0.3
Fasting Glucose	0.4	0.5	1.0	1.0	-0.7	0.1
Neuroticism (2016)	0.4	0.5	0.9	-0.8	-0.9	0.3
BMI	0.4	2.5	3.8	-1.0	-1.9	1.7
Respiratory disease	0.4	1.0	2.0	0.5	0.8	1.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	0.8	0.3	-0.9	-0.9
Supplements: Zinc	0.4	0.4	0.7	0.4	0.8	0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	-0.5	0.2	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.1	-0.1	0.7	1.5
Medication: Simvastatin	0.4	0.5	1.1	1.1	-0.0	-0.7
Prospective memory result	0.4	0.5	0.9	-0.5	-0.6	0.9
Blood clot in the leg (DVT)	0.4	0.6	1.2	0.6	1.1	-0.4
Leg fat mass (right)	0.4	1.6	3.2	-0.6	-1.8	1.2
Leg fat-free mass (right)	0.4	2.2	4.8	0.2	-1.3	-2.2
Leg predicted mass (right)	0.4	2.2	4.7	0.2	-1.3	-2.2
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	1.1	-0.8	0.3
Miserableness	0.4	0.7	1.4	0.2	-1.2	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	1.2	-0.2	-0.0
Medication: Atorvastatin	0.4	0.5	1.1	1.1	-0.3	-0.4
Basal metabolic rate	0.4	2.4	6.7	0.0	-0.6	-2.6
Diastolic blood pressure, automated reading	0.4	1.2	3.2	0.3	0.4	1.8
Leg fat mass (left)	0.4	1.7	3.3	-0.5	-1.8	1.3
Bipolar Disorder (2018)	0.3	0.5	1.1	0.6	1.1	-0.2
Neuroticism (Nagel 2018)	0.3	0.7	1.3	0.7	-1.1	0.5
Mean Putamen Volume	0.3	0.4	1.0	0.3	1.0	0.0
Schizophrenia (2014)	0.3	0.7	1.1	-0.8	0.4	1.1
Blood White Count	0.3	2.0	4.4	0.7	2.1	-1.1
Average weekly spirits intake	0.3	0.4	0.5	-0.7	-0.7	-0.3
Systolic blood pressure, automated reading	0.3	0.7	2.2	-0.2	0.2	1.5
Medication: Co-codamol	0.3	0.3	0.6	0.8	0.6	0.1
Leg fat-free mass (left)	0.3	1.8	4.0	0.0	-1.2	-2.0
Average weekly fortified wine intake	0.3	0.4	0.5	-0.7	0.7	-0.3
High blood pressure	0.3	0.8	2.2	1.5	0.2	0.5
Leg predicted mass (left)	0.3	1.8	4.0	0.0	-1.1	-2.0
Weight	0.3	1.3	2.1	-0.3	-1.5	-1.3
Hip circumference	0.3	1.3	2.2	-0.9	-1.5	0.9
Birth weight of first child	0.3	0.5	1.1	1.1	0.6	0.3
Number of full brothers	0.3	0.4	0.5	0.7	0.5	-0.7
Worry too long after embarrassment	0.3	0.4	0.9	0.6	0.0	-0.9
Pulse rate, automated reading	0.3	1.1	3.1	-0.2	0.3	-1.8
Chest pain or discomfort	0.3	0.4	0.7	0.8	-0.4	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.9	-0.2	-0.9	0.2
Supplements: Vitamin C	0.3	0.3	0.7	-0.4	0.1	0.9
Hypertension (Self-reported)	0.3	1.0	2.5	1.6	-0.4	0.5
Illnesses of siblings: Diabetes	0.3	0.4	0.6	0.2	-0.8	-0.7
Mineral and other dietary supplements	0.3	0.4	0.9	-0.3	-0.3	-0.9
Supplements: Calcium	0.3	0.3	1.0	-1.0	0.3	-0.0
Bipolar Disorder or Schizophrenia	0.2	0.4	0.6	-0.7	0.4	0.8
Breast Cancer	0.2	0.5	1.1	1.1	0.5	0.4
Coronary Artery Disease (CAD)	0.2	0.2	0.7	0.3	-0.8	-0.1
Lupus	0.2	0.4	0.7	0.8	-0.5	-0.5
Triglycerides	0.2	0.4	0.9	-0.9	0.1	0.5
Systolic Blood Pressure	0.2	1.1	2.4	1.6	-0.2	0.9
Ever had hysterectomy (womb removed)	0.2	0.3	0.4	-0.4	-0.6	-0.5
Impedance of leg (right)	0.2	0.8	2.2	0.1	1.5	-0.1
Waist circumference	0.2	0.8	2.1	-0.2	-1.5	0.6
Nervous feelings	0.2	0.4	0.6	0.8	-0.2	0.7
Illnesses of siblings	0.2	0.2	0.7	-0.2	0.8	0.0
Neuroticism score	0.2	0.5	0.8	-0.6	-0.6	0.9
Lung cancer (father)	0.2	0.2	0.3	0.5	-0.4	-0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	0.1	-0.1	-0.8
Glaucoma (self-reported)	0.2	0.2	0.5	0.7	-0.2	0.2
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.7	0.0	-0.7
Mean time to correctly identify matches	0.2	0.4	0.9	-0.3	0.9	-0.4
Heart disease (mother)	0.2	0.3	0.7	-0.3	0.2	0.8
Average weekly red wine intake	0.2	0.3	0.5	0.4	0.5	0.7
Medication for cholesterol	0.2	0.2	0.7	0.8	-0.1	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	0.3	-0.7	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.8	-1.3	0.2	-0.1
Cholesterol lowering medication	0.2	0.2	0.6	0.3	0.8	0.1
Reaction Time	0.1	0.2	0.5	-0.2	0.7	0.2
HDL Cholesterol	0.1	0.2	0.5	-0.2	0.5	0.7
Lung FEV1/FVC ratio	0.1	0.4	1.0	-0.2	-1.0	0.5
Lung FVC	0.1	0.7	1.6	-1.3	0.3	-0.7
Neuroticism	0.1	0.2	0.2	-0.3	0.4	0.4
Chronotype (morning person)	0.1	0.2	0.6	-0.3	0.8	0.2
Hair Pigment	0.1	2.0	4.4	-0.7	-1.1	2.1
Tanning	0.1	1.1	1.8	-0.7	-0.9	1.4
Sensitivity / hurt feelings	0.1	0.2	0.6	-0.1	-0.8	-0.1
Impedance of leg (left)	0.1	0.5	1.3	0.3	1.1	-0.1
Impedance of arm (right)	0.1	0.4	0.7	-0.1	0.8	0.6
Falls in the last year	0.1	0.1	0.2	0.2	0.1	0.4
Number of live births	0.1	0.2	0.4	0.7	-0.2	0.2
Pulse rate	0.1	0.3	0.5	-0.3	0.4	0.7
Noisy workplace	0.1	0.1	0.2	-0.3	0.4	-0.2
Impedance of arm (left)	0.1	0.3	0.3	-0.5	0.6	0.4
Length of working week for main job	0.1	0.1	0.3	-0.1	-0.6	0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.0	0.4	-0.8
Shortness of breath walking on level ground	0.1	0.1	0.1	0.3	0.2	0.3
Migraine (self-reported)	0.1	0.1	0.2	-0.2	-0.2	-0.4
Long-standing illness, disability or infirmity	0.1	0.2	0.3	0.4	-0.5	-0.4
Wears glasses or contact lenses	0.1	0.1	0.2	-0.3	0.4	0.3
Financial situation satisfaction	0.1	0.1	0.2	-0.5	0.0	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.2	0.1	0.6
Heart disease (siblings)	0.1	0.1	0.3	-0.5	0.1	0.2
Impedance of whole body	0.1	0.6	1.7	-0.1	1.3	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.1	0.1	-0.4	-0.2	-0.1
Diabetes (father)	0.0	0.0	0.1	0.2	-0.0	0.2
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.1	0.1	-0.3
Worrier / anxious feelings	0.0	0.0	0.1	-0.2	0.2	0.1
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.2	0.1	-0.3

Hub : Genes

PTPN1

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Trait associations