Hub : Genes

UBE2V1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1130 0.0440 0.00350 0.049 NA 0.062 NA 0.052 7.2e-05 NA 8.6e-06 NA 4.6e-05
2 GTEx Cells Transformed fibroblasts 0.1150 0.0440 0.00520 0.033 NA 0.012 NA 0.023 1.6e-03 NA 3.9e-02 NA 7.5e-03
3 GTEx Colon Sigmoid 0.2640 0.0800 0.00029 0.108 NA 0.045 NA 0.014 1.2e-04 NA 1.1e-02 NA 1.0e-01
4 GTEx Pituitary 0.3280 0.1160 0.00800 0.014 NA -0.009 NA 0.033 1.4e-01 NA 6.4e-01 NA 5.1e-02
5 GTEx Thyroid 0.1120 0.0430 0.00290 0.039 NA 0.020 NA 0.023 5.4e-04 NA 1.1e-02 NA 6.4e-03
6 TCGA Head and Neck Squamous Cell Carcinoma 0.0353 0.0189 0.00030 0.031 0.025 0.011 NA 0.021 2.0e-04 0.00074 1.8e-02 NA 2.0e-03
7 TCGA Thyroid Carcinoma 0.0660 0.0380 0.00054 0.003 0.014 0.008 NA 0.003 1.4e-01 0.01500 4.7e-02 NA 1.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.5 2.3 3.6 1.7 0.6 1.8 -0.3 1.8 -1.9 1.7
Bipolar Disorder or Schizophrenia 0.6 1.4 5.2 0.4 0.6 2.3 -0.6 0.6 -1.7 1.0
Depressed Affect (Nagel 2018) 1.0 2.1 3.4 -1.2 -1.3 -1.4 0.3 -1.8 1.7 -1.8
Depression (Nagel 2018) 0.4 0.5 2.2 1.5 -0.9 0.1 0.4 0.7 -0.4 -0.1
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.8 -0.5 -1.0 -0.4 0.5 -1.7 0.8 -1.2
Neuroticism (Nagel 2018) 0.7 1.5 3.0 -0.8 -1.5 -0.7 -0.0 -1.7 1.6 -1.3
Schizophrenia (2018) 0.3 0.6 2.6 -0.8 -0.0 1.6 -0.5 -0.7 -0.5 -0.0
Schizophrenia vs Biploar Disorder 1.2 1.6 3.8 -0.1 -0.2 -0.5 -1.8 -1.9 1.3 -1.5
Worry (Nagel 2018) 1.0 2.2 4.8 -1.1 -1.9 -1.3 -0.2 -1.7 2.2 -1.0
Alzheimer’s Disease (in mother) 1.5 1.8 4.6 0.1 -1.6 -0.6 -2.1 -1.4 1.5 -0.9
Alzheimer’s Disease (in father) 0.9 1.0 1.5 1.1 0.5 1.2 -0.3 1.1 -1.2 1.0
Alzheimer’s Disease (including proxy) 0.6 0.8 3.6 0.6 -0.8 -0.1 -1.9 -0.7 0.9 -0.2
Crohns Disease (2017) 0.8 1.8 5.7 0.7 1.4 2.4 -0.2 1.4 -1.5 0.2
Irritable Bowel Disease (IBD) 0.4 1.0 2.8 -0.0 -1.0 0.1 -1.2 -1.1 0.9 -1.7
Ulcerative Colitis (UC) 2.3 4.3 6.6 -0.8 -2.4 -1.9 -1.0 -2.6 2.5 -2.5
Major Depression (MDD) 1.9 2.3 8.7 2.9 0.7 0.9 -0.9 1.2 -1.0 1.6
Reaction Time 0.4 0.7 3.3 1.0 -0.6 1.8 0.3 -0.1 -0.7 0.0
Verbal and Numeric Reasoning (VNR) 1.6 3.8 6.4 -1.2 -2.5 -1.2 -0.4 -2.5 2.2 -2.4
Breast Cancer 0.9 2.2 6.9 -2.6 -0.7 0.1 2.6 -0.7 -0.6 0.4
Ovarian Cancer 0.2 0.3 0.9 -0.6 -0.4 1.0 0.4 0.2 -0.3 0.5
Prostate Cancer 0.5 0.8 3.4 0.1 0.3 -1.2 -1.8 -0.2 0.5 0.3
Age at First Birth 0.6 0.9 2.2 0.6 0.9 0.1 1.1 1.5 -1.2 0.7
Bipolar Disorder (2011) 0.1 0.1 0.4 0.4 -0.2 0.3 0.1 0.6 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.3 2.7 -1.2 -1.2 -1.6 1.0 -1.2 0.8 -0.6
Coronary Artery Disease (CAD) 0.3 0.4 1.3 -0.5 -0.8 -0.2 0.3 -0.6 -0.1 -1.1
Crohns Disease (2012) 0.7 1.1 2.1 0.6 1.1 1.4 0.3 1.4 -1.4 0.2
Mean Putamen Volume 2.2 2.5 4.7 0.1 2.2 1.0 1.2 1.9 -1.7 1.9
Fasting Glucose 0.5 0.6 1.0 0.8 -0.5 1.0 0.9 1.0 -0.5 -0.6
HbA1C 0.5 0.5 1.3 0.8 -0.4 -0.1 -1.1 0.8 -0.6 0.7
HDL Cholesterol 0.1 0.1 0.6 0.3 0.2 0.4 -0.1 -0.1 0.8 -0.3
LDL Cholesterol 0.3 0.5 1.0 -0.9 0.9 0.0 0.3 0.8 -0.4 1.0
Lupus 0.2 0.4 0.8 0.7 -0.9 -0.0 -0.0 -0.8 0.7 -0.4
Neuroticism (2016) 1.7 2.5 6.1 -0.7 -1.1 -1.8 -1.5 -2.5 1.6 -1.1
Primary Biliary Cirrhosis 0.6 0.8 3.8 -0.8 -0.5 0.4 -0.5 -0.8 0.3 -1.9
Rheumatoid Arthritis 0.1 0.2 0.6 -0.1 0.2 0.3 -0.2 0.5 0.8 -0.0
Schizophrenia (2014) 0.3 0.6 2.1 -0.5 -0.4 0.8 -1.5 -0.8 -0.3 -0.1
Triglycerides 0.7 1.1 2.4 0.8 0.7 1.4 0.4 0.3 -1.4 1.5
Type 2 Diabetes (T2D) (2012) 1.7 1.9 3.5 0.9 1.2 1.7 -1.1 1.5 -1.9 1.1
Ulcerative Colitis 4.0 5.8 10.1 -1.3 -2.6 -1.9 -1.3 -3.2 2.9 -2.9
Blood Eosinophil Count 0.4 2.8 5.2 -1.7 -2.3 -1.9 1.0 -0.5 1.5 -2.0
Blood Platelet Count 0.2 2.8 6.0 -0.8 0.6 2.0 -1.6 2.1 -1.2 2.4
Blood Red Count 1.7 15.9 39.8 -6.3 -2.2 -3.6 1.4 -4.4 3.9 -4.1
Blood White Count 0.4 3.1 11.3 -2.0 -0.6 -2.2 3.4 0.9 0.3 0.1
Heel T-Score 1.4 10.8 23.8 -4.9 -2.9 -3.1 -0.1 -3.9 3.1 -3.0
BMI 0.1 0.3 1.0 -0.9 -0.5 -0.3 1.0 0.4 -0.1 -0.0
Height 0.2 4.8 7.3 1.4 0.3 -2.4 2.4 -2.3 2.7 -2.6
Waist Hip Ratio (WHR) 0.1 0.5 2.2 1.5 0.2 -0.9 0.3 -0.3 -0.0 -0.2
Systolic Blood Pressure 0.1 0.5 2.3 -1.5 -1.1 -0.1 -0.2 0.3 0.2 -0.2
Smoking Status 0.2 0.4 1.0 -0.8 -0.6 0.6 0.2 -0.3 0.5 -1.0
Allergy or Eczema 0.2 0.6 1.7 -0.6 -0.0 0.4 -0.7 1.3 -1.3 -0.2
Cardiovascular Disease 0.2 0.7 2.5 -0.1 0.4 0.1 -0.4 1.6 -0.6 1.4
Hypothyroidism (self reported) 0.5 1.1 2.9 1.6 1.7 -0.4 -0.4 0.3 -0.6 1.0
Respiratory disease 2.8 6.2 11.0 1.8 1.2 3.0 -3.3 2.9 -2.3 2.1
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.5 1.6 0.2 0.2 -0.4 0.4 0.8 0.7
Lung FEV1/FVC ratio 0.4 1.9 8.6 -0.3 -0.7 -0.8 2.9 -0.7 1.0 -1.4
Lung FVC 0.7 3.8 13.8 0.6 3.7 2.4 -0.9 -0.4 -2.1 1.2
Neuroticism 0.4 0.9 1.8 -0.9 -0.4 -0.9 0.9 -1.3 1.2 -1.0
Chronotype (morning person) 0.1 0.2 0.6 0.6 0.2 0.6 0.1 0.8 -0.1 0.4
Hair Pigment 0.0 1.0 5.8 -2.4 0.6 0.3 0.3 -0.8 0.3 -0.6
Tanning 0.2 2.0 4.2 -0.3 -1.8 -1.0 0.4 -2.0 2.0 -1.1
Hand grip strength (left) 0.3 0.8 2.5 -0.2 -0.9 -0.8 0.2 -1.6 0.6 -1.0
Number of treatments/medications taken 0.1 0.2 0.7 -0.2 -0.7 -0.3 -0.3 0.4 0.1 -0.9
Average weekly spirits intake 1.3 1.6 3.8 -0.1 -1.9 -0.2 1.1 -1.9 1.4 -0.8
Sensitivity / hurt feelings 0.2 0.3 1.2 -0.1 0.1 -0.4 0.9 -1.1 0.4 -0.1
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.3 1.5 -0.2 0.2 1.3 0.6 -0.5 0.6
Hearing difficulty/problems: Yes 1.8 2.7 5.1 -1.1 -1.8 -1.8 0.6 -1.4 2.0 -2.3
Relative age of first facial hair 0.4 0.9 2.2 -0.6 1.5 0.8 -1.5 0.6 -0.7 0.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 2.6 1.6 0.3 -0.0 0.3 0.5 -0.3 -0.4
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.6 0.1 -0.3 -0.8 0.8 0.5 0.0 0.3
Ever had hysterectomy (womb removed) 0.3 0.4 1.8 0.3 -1.4 -0.1 0.2 -0.4 0.6 -0.5
Systolic blood pressure, automated reading 0.2 0.6 3.8 -1.9 -0.6 0.2 -0.1 0.0 0.1 0.1
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 4.7 -2.2 -0.5 -1.5 0.3 -1.0 0.7 0.1
Angina 1.5 2.0 5.4 2.3 1.1 -0.0 1.0 1.7 -0.9 1.6
Medication for hormone replacement therapy 0.6 0.7 1.4 -1.2 -0.6 -1.2 0.2 -0.6 0.9 -0.6
Vitamin and mineral supplements 2.2 3.0 6.2 -0.9 -1.3 -1.5 0.8 -2.2 2.5 -2.2
Supplements: Zinc 0.4 0.5 2.4 -1.6 0.1 -0.8 0.0 -0.0 -0.3 0.1
Medication: Co-codamol 0.3 0.3 1.3 -0.4 -0.3 -0.7 1.1 -0.2 0.1 -0.3
Medication: Metformin 0.5 0.7 3.2 1.8 0.0 0.2 0.7 1.0 0.3 0.1
Diabetes (father) 1.6 2.0 2.5 1.6 1.3 1.6 -0.5 1.5 -1.6 1.6
Diabetes (mother) 0.4 0.5 2.3 1.5 -0.4 0.7 -0.0 0.3 -0.3 0.2
Severe depression (siblings) 1.9 2.2 4.1 0.4 1.4 1.5 1.0 1.9 -2.0 1.5
Pack years adult smoking proportion 0.2 0.2 0.6 0.3 0.5 -0.4 0.2 0.8 -0.5 0.5
Impedance of leg (right) 0.5 2.5 6.0 -0.2 -1.9 -0.5 -2.5 -1.9 1.9 -0.3
Leg fat-free mass (left) 0.2 1.2 7.6 -0.2 0.4 -0.4 2.8 0.1 0.2 -0.7
Trunk fat percentage 0.0 0.1 0.4 -0.2 -0.5 -0.3 0.1 -0.1 0.7 0.4
Hand grip strength (right) 0.9 2.5 6.1 -1.1 -1.3 -1.3 1.1 -2.5 1.2 -2.0
Townsend deprivation index at recruitment 0.2 0.3 0.7 -0.8 -0.0 0.6 -0.4 -0.1 0.7 -0.7
Current tobacco smoking 0.3 0.5 2.6 0.4 0.5 1.6 -0.1 0.0 -0.7 -0.2
Average weekly fortified wine intake 0.4 0.5 1.5 -0.1 0.4 1.1 -1.2 0.7 -0.4 0.1
Maternal smoking around birth 1.0 1.5 3.8 0.5 1.7 0.9 0.5 1.3 -0.9 1.9
Fed-up feelings 0.3 0.5 1.1 -0.8 -0.1 -1.1 0.6 -0.7 0.8 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 0.7 -0.7 -0.5 -0.9 -0.4 0.2 -0.3
Relative age voice broke 0.8 1.2 4.1 -0.1 2.0 1.4 -0.2 1.0 -0.6 0.9
Taking other prescription medications 0.6 0.9 3.2 0.1 0.2 0.3 1.2 1.8 -0.9 0.6
Age when periods started (menarche) 0.3 0.7 1.8 -1.4 -0.8 -1.3 0.2 -0.4 0.7 -0.3
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 5.1 -1.5 -2.3 -0.8 0.9 -1.6 2.1 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 1.3 2.9 5.6 -1.6 -2.2 -0.7 1.2 -2.4 1.8 -1.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 3.2 -0.0 0.1 -0.2 1.8 -0.3 0.3 -0.7
Qualifications: CSEs or equivalent 0.6 0.8 1.8 1.0 1.3 0.7 -0.2 0.5 -0.8 1.3
Serious illness, injury or assault to yourself 7.6 9.2 17.5 4.2 1.7 2.6 -2.6 4.2 -2.4 2.7
High blood pressure 0.4 1.2 4.3 -2.1 -1.6 -0.9 0.0 -0.0 0.9 -0.5
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.9 -1.0 -0.5 0.1 -1.4 0.3 -0.6 -0.6
Multivitamins +/- minerals 3.2 4.0 9.0 0.9 1.2 2.1 -0.3 2.6 -3.0 2.4
Stomach or abdominal pain in last month 0.4 0.5 1.4 1.2 0.6 0.4 -1.1 -0.3 -0.3 0.1
Supplements: Glucosamine 1.5 1.9 3.8 0.8 1.4 1.7 -0.4 2.0 -1.8 1.1
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.5 -0.3 -0.7 -0.1 0.1 -0.6 -0.0 -0.3
Medication: Atenolol 0.5 0.7 3.5 1.9 0.1 -0.5 -0.2 0.9 -0.2 0.3
Medication: Levothyroxine sodium 0.2 0.4 0.7 0.7 0.8 -0.8 -0.1 0.0 0.1 0.8
Sitting height 0.7 4.7 9.2 2.6 3.0 0.8 3.0 1.7 -1.6 1.5
Chronic bronchitis/emphysema (father) 0.5 0.6 2.5 0.6 0.0 1.0 -1.6 0.5 -0.4 0.4
High blood pressure (mother) 2.0 2.8 6.8 1.0 1.7 1.3 -1.5 1.5 -1.6 2.6
Body mass index (BMI) 0.1 0.3 0.8 -0.1 -0.2 0.5 0.9 0.4 -0.0 0.6
Impedance of leg (left) 0.3 1.4 5.1 -0.0 -1.3 -0.4 -2.2 -1.3 1.1 0.2
Leg predicted mass (left) 0.2 1.2 7.4 -0.2 0.4 -0.4 2.7 0.0 0.3 -0.8
Trunk fat mass 0.1 0.4 1.7 -0.4 -0.3 -0.5 1.3 -0.1 0.7 0.2
Waist circumference 0.1 0.4 2.6 0.1 0.4 0.2 1.6 0.4 -0.0 0.2
Number of incorrect matches in round 0.1 0.1 0.3 0.5 -0.4 0.5 0.1 -0.0 0.1 -0.1
Past tobacco smoking 0.1 0.3 1.3 0.3 0.1 -1.1 -0.4 -0.5 0.2 0.2
Alcohol usually taken with meals 0.5 0.7 2.8 -0.6 -0.1 -1.3 -1.7 -0.2 0.2 -0.3
Nervous feelings 0.2 0.3 1.0 -0.1 -0.0 0.1 -1.0 -0.3 0.9 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.8 -0.8 -0.6 -1.1 1.3 -0.6 0.4 0.1
Hearing difficulty/problems with background noise 0.9 1.4 3.2 -0.9 -1.2 -1.8 1.1 -0.5 0.7 -1.6
Hair/balding pattern: Pattern 2 0.3 0.3 1.6 1.3 0.4 0.4 0.4 0.3 -0.1 0.1
Had menopause 1.0 1.2 4.0 0.3 -2.0 -0.4 -0.1 -0.9 0.9 -1.7
Had other major operations 1.8 2.3 3.6 0.9 1.7 0.6 -1.4 1.9 -1.6 1.9
Forced vital capacity (FVC) 1.1 4.4 14.5 1.9 3.8 1.9 1.2 0.8 -2.0 1.6
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 4.8 -2.1 -2.2 -0.8 0.1 -2.1 1.5 -1.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.4 0.5 0.2 0.4 -1.2 0.5 -0.1 0.1
Qualifications: None of the above 0.3 0.6 1.7 0.9 0.0 0.0 1.1 1.3 -0.3 0.7
Financial difficulties in last 2 years 0.4 0.6 3.1 -1.8 -0.1 -0.5 0.2 -0.5 0.5 -0.2
Mouth/teeth dental problems 0.6 0.9 3.2 -0.6 -0.5 -1.8 -0.1 -1.1 0.6 -1.0
Heart attack 0.4 0.5 1.6 1.3 -0.8 -0.3 -0.5 0.9 0.2 -0.1
Allergy 0.8 1.7 6.2 -0.1 0.6 -1.6 2.5 -1.4 1.1 0.1
Pain all over the body in last month 0.4 0.4 1.0 -1.0 -0.0 -0.1 -0.6 1.0 -0.7 0.4
Diabetes (self-reported) 0.2 0.3 1.5 1.2 0.3 0.3 -0.1 0.7 0.1 0.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.9 4.3 -0.4 -0.7 -0.2 -2.1 -0.3 0.5 -0.8
Medication: Ramipril 0.9 1.2 2.8 1.7 0.8 0.9 0.1 1.2 -1.1 1.1
Medication: Simvastatin 0.3 0.4 1.4 1.2 0.7 -0.4 0.1 0.5 -0.2 0.8
Fluid intelligence score 0.8 1.7 3.3 -1.0 -1.8 -0.9 -1.0 -1.7 1.5 -1.0
Illnesses of siblings 0.3 0.4 0.8 -0.2 -0.8 -0.8 0.2 -0.7 0.6 -0.9
Neuroticism score 0.6 1.2 2.0 -1.3 -0.4 -1.3 1.1 -1.4 1.1 -0.7
Weight 0.2 0.9 5.5 0.2 -0.2 -0.3 2.3 -0.1 0.6 -0.2
Impedance of arm (right) 0.4 1.7 7.9 1.7 0.4 0.2 -2.8 0.2 0.3 0.9
Arm fat percentage (right) 0.1 0.2 1.0 0.4 -0.1 0.6 -0.1 0.4 0.2 1.0
Trunk fat-free mass 0.5 2.6 13.8 -0.6 0.1 -0.8 3.7 -0.7 0.8 -1.6
Hip circumference 0.1 0.5 2.7 -0.7 -0.1 0.3 1.6 0.0 0.5 0.0
Time employed in main current job 0.4 0.5 1.3 0.0 1.1 0.4 0.3 0.8 -0.7 0.8
Alcohol intake versus 10 years previously 1.3 2.0 4.3 2.1 0.9 1.4 -0.0 1.9 -1.5 1.0
Father’s age at death 3.1 4.2 6.2 -2.3 -1.6 -1.6 1.4 -2.4 2.2 -2.5
Worrier / anxious feelings 0.1 0.3 1.0 -1.0 0.3 -0.4 0.2 -0.5 0.5 0.2
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.6 5.5 2.3 1.8 1.0 0.5 2.4 -2.2 2.3
Falls in the last year 1.7 2.3 5.3 2.3 -0.7 1.6 -1.9 1.6 -1.0 0.9
Hair/balding pattern: Pattern 3 1.0 1.4 5.4 -2.0 0.0 -0.4 -2.3 -0.3 0.5 0.2
Number of live births 0.5 0.7 1.9 0.9 -0.1 0.9 0.2 1.4 -0.6 0.8
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 10.1 2.2 3.2 1.5 1.6 0.8 -1.7 1.3
Pulse rate 0.7 1.2 2.7 -1.0 -1.0 -0.8 -0.4 -1.6 1.6 -0.7
Happiness 0.9 1.1 4.5 0.3 -0.8 -0.5 -1.2 -0.9 0.4 -2.1
Noisy workplace 0.6 0.7 2.2 1.5 1.3 0.9 -0.2 0.2 -0.6 0.2
Qualifications: A levels/AS levels or equivalent 0.4 1.0 1.4 1.2 0.8 1.1 -0.8 0.9 -1.2 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.5 -0.4 0.4 -0.1 -0.7 0.4 0.0 -0.2
Mouth/teeth dental problems: Dentures 0.0 0.1 0.4 -0.0 0.1 0.7 0.2 0.1 -0.0 0.2
Asthma 2.3 4.6 8.6 2.1 1.1 2.9 -2.9 2.2 -1.9 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.7 -0.4 -1.3 -0.7 -0.9 -0.3 1.3 -0.5
Medication: Cholesterol lowering 0.7 1.1 4.3 -0.5 -0.3 -2.1 -0.5 -0.2 1.0 -1.3
Depression (self-reported) 0.2 0.3 1.1 1.1 0.0 0.4 0.8 0.3 -0.2 -0.0
Medication: Lansoprazole 0.3 0.3 1.5 -0.4 -0.2 -0.4 -0.1 -1.2 0.6 -0.3
Prospective memory result 0.1 0.2 0.4 -0.3 0.4 0.1 -0.6 0.7 -0.3 0.3
Lung cancer (father) 0.2 0.3 0.7 0.8 -0.0 0.4 -0.6 0.5 -0.4 -0.5
Illnesses of mother 1.1 1.3 2.8 -0.5 -1.2 -0.7 1.7 -1.3 1.1 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.6 9.1 2.1 3.0 1.9 1.4 0.9 -1.8 1.5
Pulse wave Arterial Stiffness index 2.1 2.4 3.9 -0.3 1.7 1.8 -0.4 1.7 -1.9 2.0
Impedance of arm (left) 0.2 1.0 4.7 1.2 0.3 -0.2 -2.2 -0.2 0.4 0.6
Arm fat mass (right) 0.0 0.2 0.8 -0.0 -0.1 0.2 0.9 0.1 0.4 0.5
Trunk predicted mass 0.4 2.5 13.1 -0.6 0.1 -0.8 3.6 -0.7 0.8 -1.5
Standing height 0.3 3.0 11.6 0.4 0.1 -1.8 3.4 -1.0 1.3 -1.8
Length of working week for main job 0.1 0.1 0.3 0.5 0.1 0.0 -0.4 0.3 -0.4 -0.1
Exposure to tobacco smoke at home 0.1 0.2 0.6 -0.7 -0.4 -0.3 -0.4 0.3 -0.0 0.2
Breastfed as a baby 2.9 3.6 7.4 -2.7 -0.7 -2.7 1.2 -1.5 1.5 -2.0
Tense / ‘highly strung’ 1.2 1.9 3.3 -1.4 -1.4 -1.8 0.7 -1.3 1.7 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 2.2 0.5 1.5 1.3 0.8 1.3 -1.0 0.8
Hair/balding pattern: Pattern 4 0.7 1.7 6.4 -0.4 -0.6 -0.9 2.5 -1.6 1.0 -1.0
Birth weight of first child 1.2 2.2 5.0 0.6 1.7 2.2 -0.6 1.2 -1.4 1.8
Peak expiratory flow (PEF) 0.5 1.1 3.9 -0.3 1.4 -0.9 2.0 -0.5 0.4 -0.7
Pulse wave reflection index 2.3 2.8 5.2 0.7 1.6 2.2 -0.8 1.7 -2.3 1.8
Ever highly irritable/argumentative for 2 days 1.3 1.6 2.4 0.8 1.6 1.4 -1.3 1.2 -1.0 1.4
Loud music exposure frequency 1.2 1.3 2.5 -0.5 0.5 1.6 -1.0 1.2 -1.3 1.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 4.0 0.0 -0.0 0.5 -2.0 -1.2 -0.1 -0.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 2.5 -0.8 -0.9 -0.3 -0.2 -1.0 1.6 -0.2
Blood clot in the leg (DVT) 0.2 0.2 0.8 0.2 0.1 0.5 -0.5 0.9 0.0 -0.2
Medication: Paracetamol 0.6 1.0 1.9 1.2 0.1 1.4 0.3 1.2 -0.6 1.1
Headache pain in last month 0.3 0.5 1.5 0.7 -0.2 -1.1 1.2 0.2 0.5 -0.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.6 0.1 0.5 1.3 0.2 -0.1 -0.8 0.9
Glaucoma (self-reported) 0.5 0.6 2.7 0.4 0.4 0.6 -1.7 0.4 0.4 0.5
Gout (self-reported) 1.0 1.4 2.9 1.3 0.7 -0.3 0.1 1.7 -1.4 1.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.2 1.5 1.4 -0.8 0.1 -0.1 -0.3 0.9
Medication: Amlodipine 0.3 0.4 1.0 -0.1 -0.8 -0.9 -0.1 -1.0 0.5 -0.3
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.2 -0.6 -1.5 0.2 -0.9 -0.7 0.9 -1.4
Birth weight 0.7 1.6 3.9 0.7 0.2 2.0 0.8 1.4 -1.3 1.4
Chronic bronchitis/emphysema (mother) 1.1 1.3 3.8 1.9 1.1 0.5 -1.6 0.7 -0.4 1.0
High blood pressure (siblings) 0.3 0.5 1.4 -0.5 0.8 0.4 -0.5 0.6 -0.5 1.2
Forced vital capacity (FVC), Best measure 0.9 3.4 9.6 1.7 3.1 1.7 0.8 0.9 -2.0 1.7
Body fat percentage 0.0 0.2 0.5 -0.3 -0.6 -0.0 0.0 -0.1 0.7 0.6
Leg fat percentage (right) 0.1 0.5 1.3 -0.7 -1.1 0.1 -0.2 -0.7 1.1 0.6
Arm fat-free mass (right) 0.5 2.4 11.9 -1.1 -0.5 -0.7 3.5 -0.6 0.7 -1.4
Exposure to tobacco smoke outside home 1.0 1.3 2.3 0.9 1.3 1.3 0.6 1.0 -1.1 1.5
Comparative body size at age 10 0.3 0.9 2.2 -1.4 0.5 0.2 1.4 -0.3 -0.2 -1.5
Number of full brothers 0.9 1.2 2.2 1.4 0.9 1.1 -1.0 0.9 -0.6 1.5
Worry too long after embarrassment 0.9 1.5 5.7 -1.4 -0.9 -0.7 2.4 -0.9 0.4 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.8 -0.4 -0.5 -0.2 0.0 -0.0 0.9 -0.2
Wheeze or whistling in the chest in last year 1.4 2.5 7.4 0.3 0.9 2.1 0.2 2.7 -1.7 1.4
Number of children fathered 1.9 2.1 3.8 -0.1 1.6 1.8 0.9 1.9 -1.7 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 2.0 -0.9 -0.6 -1.4 0.6 -0.3 1.2 -1.0
Age at first live birth 0.5 1.0 3.7 -1.1 -0.4 -0.5 -1.0 -0.4 0.5 -1.9
Pulse wave peak to peak time 2.2 2.6 4.1 0.4 -1.8 -1.9 0.8 -1.6 2.0 -2.0
Health satisfaction 0.8 1.0 2.0 1.4 1.2 0.5 -0.7 1.1 -0.7 1.2
Shortness of breath walking on level ground 0.6 0.7 3.7 -0.0 0.1 0.4 -1.9 -0.5 0.7 -0.6
Qualifications: College or University degree 0.2 0.7 2.2 -0.8 -0.3 -0.0 -1.3 -0.6 0.2 -1.5
Eye problems/disorders: None of the above 0.3 0.4 1.4 0.5 -0.6 0.5 0.3 -0.4 0.1 -1.2
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.6 0.0 0.9 0.8 1.6 0.1 -0.3 -0.1
Emphysema/chronic bronchitis 0.3 0.3 1.4 0.5 -1.2 -0.2 0.3 0.6 0.4 0.4
Medication for pain relief, constipation, heartburn 0.2 0.4 0.7 -0.8 0.8 0.4 0.7 0.0 -0.9 0.2
Neck or shoulder pain in last month 0.1 0.2 0.6 0.7 0.1 0.5 0.2 0.7 -0.3 0.1
Medication: Blood pressure 0.2 0.3 0.7 -0.1 -0.8 -0.9 0.2 0.0 0.7 -0.4
Angina (self-reported) 1.7 2.2 6.0 2.4 1.1 -0.2 1.0 1.9 -0.9 1.8
Migraine (self-reported) 2.8 3.4 8.0 -1.3 -1.4 -2.8 0.1 -1.6 2.2 -2.2
Medication: Ibuprofen 0.7 0.9 2.2 -0.6 -1.2 -1.3 -0.1 -0.5 1.5 -0.6
Medication: Allopurinol 0.4 0.5 1.2 0.5 -0.1 -0.8 -1.0 1.1 -0.5 0.7
Medication: Omeprazole 0.9 1.1 3.2 0.4 0.6 0.0 -0.5 1.5 -1.2 1.8
Medication: Seretide 50 evohaler 1.9 2.2 6.1 -0.2 -2.5 -0.9 0.4 -0.7 1.7 -2.2
Mean time to correctly identify matches 0.2 0.4 0.8 0.6 -0.8 0.9 0.2 -0.4 -0.0 -0.9
Heart disease (mother) 0.6 0.8 1.9 -0.3 1.4 1.1 0.7 0.6 -1.0 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 2.5 1.6 1.5 0.9 -1.4 1.4 -1.0 0.4
Whole body fat mass 0.1 0.3 1.1 -0.5 -0.5 -0.4 1.0 -0.2 0.7 0.2
Leg fat mass (right) 0.1 0.3 0.6 -0.7 -0.6 -0.1 0.6 -0.4 0.8 0.3
Arm predicted mass (right) 0.4 2.2 12.4 -1.0 -0.1 -0.4 3.5 -0.5 0.4 -1.2
Pulse rate, automated reading 0.0 0.1 0.5 0.0 0.4 0.7 -0.5 -0.1 0.1 0.2
Alcohol intake frequency. 0.3 0.6 3.3 1.8 0.3 0.2 0.2 -0.3 0.3 -0.7
Comparative height size at age 10 0.1 0.6 3.2 -0.4 -0.0 -0.2 1.8 -0.1 0.1 -0.8
Number of full sisters 1.7 2.1 4.0 0.2 1.8 2.0 -0.0 1.7 -1.6 1.3
Suffer from ‘nerves’ 0.3 0.4 1.5 0.4 -0.0 -0.6 0.9 0.3 -0.3 1.2
Overall health rating 1.3 2.9 8.6 1.7 0.7 1.1 0.7 2.9 -1.5 2.0
Chest pain or discomfort 0.2 0.3 1.3 -0.3 -0.3 -0.4 -1.2 0.4 0.1 -0.0
Had major operations 0.3 0.4 1.2 -0.0 -0.4 0.9 -1.1 0.3 0.3 -0.7
Age at last live birth 0.4 0.6 2.0 -0.6 0.2 0.3 -1.4 -0.3 0.2 -1.3
Family relationship satisfaction 1.1 1.3 2.4 -0.6 -1.3 -0.7 -1.2 -1.2 1.1 -1.6
Leg pain on walking 0.5 0.6 2.8 -0.1 0.4 0.5 -1.7 -0.1 -0.6 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 0.3 0.5 -0.3 -0.4 -0.2 0.0 0.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.3 -0.3 0.2 -0.5 0.1 -1.5 1.1 -1.2
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 2.4 -0.2 -1.1 -1.3 0.2 -1.6 1.1 -1.5
Medication: Aspirin 0.2 0.3 0.9 0.9 -0.2 -0.4 -0.1 -0.0 0.5 -0.9
Supplements: Vitamin C 0.6 0.7 2.2 -0.8 1.5 0.2 0.0 0.9 -0.8 0.9
Knee pain experienced in last month 0.1 0.2 0.8 0.0 -0.2 -0.9 -0.7 0.1 0.5 -0.1
Hypertension (Self-reported) 0.2 0.7 2.0 -1.4 -1.3 -0.6 0.1 0.5 0.6 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.0 0.5 -0.3 0.6 0.4 0.1 -0.5 1.0
Illnesses of father: Heart disease 0.3 0.4 0.7 -0.3 -0.5 -0.9 -0.4 -0.7 0.8 -0.5
Illnesses of siblings: Diabetes 0.3 0.3 0.9 0.3 0.8 0.4 0.9 0.1 -0.5 0.6
Smoking status: Previous 0.2 0.2 0.8 -0.6 -0.5 0.3 0.9 0.2 0.2 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 4.1 0.4 1.7 0.5 2.0 0.7 -1.0 0.8
Whole body fat-free mass 0.4 2.1 12.3 -0.5 0.3 -0.6 3.5 -0.3 0.4 -1.2
Leg fat-free mass (right) 0.3 1.4 8.7 -0.0 0.8 -0.3 3.0 0.5 -0.2 -0.5
Arm fat percentage (left) 0.0 0.1 0.7 -0.0 -0.1 0.4 0.1 0.1 0.4 0.8
Average weekly red wine intake 0.7 1.0 4.3 -2.1 -0.4 -0.4 -1.0 -0.9 0.7 -0.4
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.0 0.9 0.9 1.0 -0.9 0.5 -0.6 0.2
Mood swings 0.5 0.8 1.8 -0.7 -0.6 -0.6 1.3 -1.2 0.8 -1.0
Loneliness, isolation 0.2 0.3 0.5 -0.7 -0.1 -0.6 -0.5 -0.6 0.5 0.4
Long-standing illness, disability or infirmity 0.4 0.6 2.2 1.2 -0.2 -0.4 -0.1 1.5 0.0 -0.2
Ever had bowel cancer screening 1.3 1.6 6.2 1.0 2.5 -0.2 -0.9 1.1 -1.1 0.7
Diabetes diagnosed by doctor 0.3 0.5 2.1 1.4 0.5 0.5 -0.1 0.7 0.3 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 3.5 1.3 0.9 1.7 -0.0 1.9 -1.4 1.8
Friendships satisfaction 1.3 1.6 2.7 -0.9 -1.6 -0.9 -0.9 -1.3 1.5 -1.4
Qualifications: nursing, teaching 0.8 1.3 3.3 -1.7 0.8 -1.1 0.5 -1.8 0.6 -0.7
Commuting to job workplace: Walk 1.0 1.1 2.6 0.9 0.4 1.2 -0.5 0.9 -1.1 1.6
Eye problems/disorders: Cataract 0.2 0.3 0.8 -0.3 0.5 -0.6 -0.1 0.5 -0.3 0.9
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.5 0.9 -0.0 0.8 -1.6 0.7 -0.7 0.4
Medication for cholesterol 0.4 0.5 1.4 -0.1 -0.5 -0.7 0.3 -1.0 0.6 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.9 -0.4 -1.4 -0.5 0.9 -1.1 1.7 -1.2
Back pain experienced in last month 0.4 0.5 2.6 -0.7 0.2 0.3 1.6 0.3 0.0 0.6
Mineral and other dietary supplements 1.2 1.6 4.1 -0.2 0.0 -1.7 1.2 -2.0 1.5 -0.7
Breast cancer (self-reported) 0.6 0.7 2.2 -0.3 0.0 -0.2 -1.5 0.9 0.4 -1.1
Asthma (self-reported) 2.4 4.7 9.5 1.9 1.1 2.9 -3.1 2.2 -1.9 1.1
Osteoporosis (self-reported) 0.7 0.9 2.1 0.1 -0.6 -1.2 1.4 -0.6 0.9 -1.3
Osteoarthritis (self-reported) 1.3 1.7 3.3 0.4 1.8 1.8 1.1 1.5 -0.8 1.0
Medication: Aspirin 0.2 0.3 0.9 1.0 0.0 -0.8 0.1 0.4 0.3 -0.5
Medication: Gliclazide 0.5 0.6 2.8 1.7 0.5 -0.4 -0.6 -0.2 0.6 -0.6
Illnesses of father: None of the above (group 1) 0.9 1.2 2.9 -0.9 -0.8 -1.1 1.7 -0.3 0.1 -1.6
Smoking status: Current 0.4 0.6 3.2 0.4 0.4 1.8 -0.3 0.2 -0.7 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 5.4 1.5 2.3 1.2 1.4 0.4 -1.5 1.7
Whole body water mass 0.4 2.2 12.6 -0.6 0.1 -0.6 3.5 -0.5 0.5 -1.3
Leg predicted mass (right) 0.3 1.4 8.5 -0.2 0.8 -0.4 2.9 0.3 -0.1 -0.6
Arm fat mass (left) 0.0 0.2 0.7 -0.3 -0.3 0.1 0.8 -0.3 0.7 0.2
Number of self-reported non-cancer illnesses 0.4 0.7 2.5 0.4 0.9 0.6 -0.7 1.6 -0.5 0.3
Average weekly champagne plus white wine intake 1.4 2.0 3.4 1.2 1.1 1.6 -0.8 1.8 -1.5 1.6
Miserableness 0.5 0.8 1.4 -1.2 -0.5 -0.7 1.0 -1.1 0.9 -0.6
Guilty feelings 0.4 0.6 1.0 -0.8 -1.0 -0.6 -0.2 -0.9 0.5 -1.0
Wears glasses or contact lenses 0.5 0.6 2.8 -0.3 -0.4 0.7 -1.7 0.1 0.1 -0.7
Ever taken oral contraceptive pill 0.2 0.2 0.4 -0.6 -0.2 -0.5 0.6 -0.1 0.6 -0.3
Hearing aid user 2.3 2.6 7.3 -1.5 -2.0 -1.5 0.0 -0.7 1.2 -2.7
Mother’s age at death 0.3 0.4 1.2 -0.7 -0.1 -0.3 -1.1 -0.2 0.5 -0.9
Financial situation satisfaction 0.7 0.9 1.7 1.3 1.3 0.8 -0.3 1.1 -0.6 0.8
Tinnitus: Yes, now most or all of the time 4.9 5.7 12.1 0.8 2.6 2.5 -0.3 2.3 -2.9 3.5
Commuting to job workplace: Public transport 0.4 0.5 1.0 -0.5 -1.0 0.3 0.8 0.7 -0.7 1.0
Eye problems/disorders: Glaucoma 0.1 0.1 0.4 0.3 0.2 0.3 -0.6 0.2 0.4 0.5
Medication: Blood pressure 0.2 0.4 2.0 -0.4 -0.4 0.2 -1.4 0.5 0.1 0.6
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.7 0.7 0.2 0.8 -0.5 0.3 0.0 -0.0
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.9 -0.6 -1.6 0.6 -1.7 0.1 0.1 -0.3
High cholesterol (Self-reported) 0.4 0.7 1.4 1.2 1.1 0.0 0.5 0.9 -0.6 1.1
Medication: Bendroflumethiazide 1.0 1.6 3.5 -0.9 -1.9 -1.1 -0.3 -0.9 1.8 -1.2
Medication: Paracetamol 0.3 0.5 1.2 0.7 -0.0 1.1 0.6 0.9 -0.2 1.0
Medication: Lisinopril 0.2 0.3 0.7 0.6 -0.4 0.8 -0.0 0.4 -0.6 0.4
Medication: Atorvastatin 0.4 0.5 2.4 -0.0 0.2 -0.4 1.5 0.9 0.1 0.2
Illnesses of father: High blood pressure 1.8 2.2 5.6 0.7 1.1 1.8 -1.7 1.1 -0.9 2.4
Alcohol drinker status: Never 0.8 0.9 2.1 0.1 -0.9 0.1 -1.1 -1.0 1.1 -1.5
Ever smoked 0.2 0.3 1.0 -0.7 -0.6 0.5 -0.1 -0.3 0.2 -1.0
Basal metabolic rate 0.3 1.8 11.2 -0.3 0.2 -0.4 3.3 -0.2 0.4 -0.8
Leg fat percentage (left) 0.1 0.3 0.7 -0.4 -0.6 0.2 -0.0 -0.3 0.7 0.8
Arm fat-free mass (left) 0.4 1.9 10.1 -0.6 -0.5 -0.3 3.2 -0.7 0.6 -1.2
Number of operations (self-reported) 0.1 0.1 0.5 -0.2 0.1 0.2 -0.7 0.5 -0.0 -0.3
Average weekly beer plus cider intake 0.3 0.5 1.3 0.5 0.5 1.1 0.3 0.6 -0.3 1.0
Irritability 0.2 0.3 1.0 0.5 0.3 0.7 -0.5 1.0 -0.5 0.2
Risk taking 0.4 0.6 1.9 -0.2 0.9 -0.4 -0.2 1.4 -0.7 0.7
Ever had prostate specific antigen (PSA) test 0.4 0.5 2.2 -0.4 0.1 -0.8 -1.5 0.5 -0.4 0.3
Fractured/broken bones in last 5 years 0.8 1.1 3.0 0.5 0.9 0.9 1.7 1.6 -0.6 0.3
Age started oral contraceptive pill 1.0 1.2 3.8 0.3 -1.2 -0.9 0.8 -0.7 1.1 -2.0
Diastolic blood pressure, automated reading 0.4 1.3 7.3 -2.7 -0.8 0.4 -0.9 -0.5 -0.1 -0.2
Ever depressed for a whole week 0.5 0.6 1.7 -0.3 1.3 0.7 -0.7 0.8 -0.8 0.5
Unable to work because of sickness or disability 0.3 0.4 1.5 0.6 0.3 0.7 0.3 1.2 -0.3 0.1
Commuting to job workplace: Cycle 0.4 0.5 1.4 -0.2 -1.1 -0.2 0.5 -0.3 0.5 -1.2
Myopia 0.5 0.8 1.7 0.6 -1.1 1.3 -0.8 0.1 0.3 -1.1
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.6 1.3 0.9 0.4 -0.2 -0.8 -0.4 -0.5
Cholesterol lowering medication 4.2 6.2 8.7 3.0 2.5 2.9 0.9 2.4 -2.5 2.7
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.2 0.1 0.5 -0.5 -0.3 1.0 -0.6 1.5
Pain experienced in last month 0.3 0.6 1.2 -0.2 -0.4 -0.7 -1.0 -1.0 0.4 -1.1
Supplements: Calcium 1.2 1.3 4.3 0.9 0.8 0.2 -0.1 1.9 -2.1 -0.0
Basal cell carcinoma (self-reported) 1.8 2.1 5.0 -0.5 -1.5 -1.4 -0.9 -1.5 1.5 -2.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.3 1.1 -0.6 -0.3 -0.3 0.9 0.2 -0.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.9 0.5 0.3 0.3 -0.7 0.9 0.0 -0.0
Heart disease (siblings) 0.2 0.3 1.2 -0.1 0.6 0.3 0.3 1.1 -0.2 0.1
Alcohol drinker status: Previous 0.2 0.2 0.5 -0.4 -0.1 -0.6 0.0 -0.7 0.6 -0.7
Pack years of smoking 0.1 0.2 0.8 -0.1 0.3 -0.9 -0.0 0.6 -0.2 0.3
Impedance of whole body 0.3 1.4 7.6 1.0 -0.4 -0.2 -2.8 -0.4 0.5 0.7
Leg fat mass (left) 0.1 0.2 0.5 -0.5 -0.3 0.0 0.7 -0.1 0.5 0.4
Arm predicted mass (left) 0.4 1.9 10.0 -0.7 -0.6 -0.1 3.2 -0.6 0.6 -1.2