TWAS hub - TMEM189

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1980	0.0660	2.3e-03	0.072	NA	0.002	NA	0.033	1.6e-05	NA	2.3e-01	NA	2.8e-03
2	GTEx	Heart Left Ventricle	0.2544	0.0721	5.9e-04	0.079	NA	0.041	NA	0.064	5.1e-05	NA	3.1e-03	NA	2.6e-04
3	GTEx	Nerve Tibial	0.1829	0.0512	6.3e-05	0.002	NA	0.047	NA	0.017	2.1e-01	NA	3.1e-04	NA	2.1e-02
4	GTEx	Skin Not Sun Exposed Suprapubic	0.3200	0.0660	2.7e-07	0.285	NA	0.261	NA	0.279	5.6e-16	NA	1.4e-14	NA	1.2e-15
5	GTEx	Skin Sun Exposed Lower leg	0.1720	0.0460	6.8e-06	0.158	NA	0.144	NA	0.146	4.6e-13	NA	5.7e-12	NA	4.3e-12
6	YFS	Blood	0.0294	0.0094	6.4e-06	0.031	0.014	0.021	0.02	0.023	2.4e-10	1.2e-05	1.3e-07	3.5e-07	4.3e-08
7	TCGA	Breast Invasive Carcinoma	0.0243	0.0141	1.1e-04	0.013	0.014	0.013	NA	0.020	9.4e-04	4.6e-04	7.4e-04	NA	4.5e-05
8	TCGA	Colon Adenocarcinoma	0.2110	0.1250	3.4e-04	0.055	0.049	0.039	NA	0.045	3.9e-04	8.2e-04	2.6e-03	NA	1.3e-03
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0252	0.0158	5.9e-03	0.006	0.011	0.015	NA	0.007	6.6e-02	2.1e-02	7.2e-03	NA	4.6e-02
10	TCGA	Lung Adenocarcinoma	0.0238	0.0134	1.2e-03	0.026	0.017	0.019	NA	0.001	4.4e-04	3.9e-03	2.1e-03	NA	2.4e-01
11	TCGA	Ovarian Serous Cystadenocarcinoma	0.0570	0.0310	4.5e-04	0.071	0.044	0.064	NA	0.029	1.6e-05	5.6e-04	4.1e-05	NA	4.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Cholesterol lowering medication	5.1	7.5	14.2	-2.3	-2.9	-1.9	-2.7	-2.8	-0.4	-3.4	-2.9	-3.8	-2.6	-2.9
Serious illness, injury or assault to yourself	5.0	6.1	15.3	-0.5	-1.7	-1.7	-1.0	-1.1	-1.7	-3.9	-2.7	-3.6	-2.9	-3.3
Tinnitus: Yes, now most or all of the time	4.8	5.6	10.1	-1.9	-2.6	-1.6	-2.2	-2.2	-0.8	-3.1	-2.1	-3.2	-2.5	-2.8
Hearing aid user	4.0	4.5	7.8	1.7	2.8	2.1	1.9	2.0	-0.2	2.4	2.7	2.2	2.3	1.9
Severe depression (siblings)	3.0	3.3	5.2	-2.2	-0.7	-1.6	-2.2	-2.3	-1.2	-1.3	-2.3	-1.4	-2.1	-2.0
Medication: Seretide 50 evohaler	3.0	3.5	7.2	1.8	2.7	-1.4	1.4	1.4	0.1	1.8	2.4	1.8	2.0	2.4
Ulcerative Colitis	2.9	4.2	9.7	0.7	1.1	0.4	1.1	1.2	2.4	2.5	2.7	2.0	3.1	3.0
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.6	8.6	-2.0	-2.2	-0.2	-2.9	-2.9	-0.2	-1.9	-2.4	-2.1	-2.5	-2.1
Multivitamins +/- minerals	2.6	3.3	13.6	-0.2	0.9	0.8	-0.6	-0.6	-3.7	-1.9	-1.6	-1.4	-2.3	-2.6
Father’s age at death	2.6	3.5	8.4	0.8	1.0	1.7	1.4	1.5	1.0	2.9	1.8	2.8	2.2	2.0
Ever had bowel cancer screening	2.6	3.1	7.9	-2.3	-1.6	-0.2	-2.0	-2.0	-0.8	-1.3	-2.8	-1.3	-1.6	-1.7
Major Depression (MDD)	2.3	2.7	6.6	-0.4	-1.7	-2.6	-1.4	-1.2	0.1	-1.8	-2.3	-1.8	-1.8	-1.6
Respiratory disease	2.2	5.0	9.4	-1.1	-0.4	-2.6	-1.8	-1.9	-2.1	-2.5	-3.1	-2.1	-2.9	-2.6
Financial situation satisfaction	2.2	2.8	5.9	-2.3	-2.1	-0.4	-2.4	-2.4	1.2	-1.3	-1.2	-1.8	-0.8	-0.6
Asthma	2.1	4.1	13.3	-1.2	0.1	-3.7	-2.0	-2.0	-1.4	-2.0	-2.3	-2.0	-2.2	-1.6
Breastfed as a baby	2.1	2.6	6.2	-0.7	0.2	1.4	-0.7	-0.5	2.5	2.4	1.3	2.0	1.9	2.0
Loud music exposure frequency	2.1	2.3	7.4	0.8	0.0	-0.8	0.3	0.3	-1.3	-2.7	-1.7	-2.1	-2.1	-1.7
Chronic bronchitis/emphysema (mother)	2.1	2.5	5.0	-1.7	-2.2	0.0	-2.0	-2.1	1.4	-1.1	-1.9	-1.4	-1.1	-1.0
Migraine (self-reported)	2.1	2.6	5.2	0.7	1.0	1.9	1.3	1.2	1.4	2.0	1.6	1.8	1.8	2.3
Asthma (self-reported)	2.1	4.1	13.0	-1.0	0.1	-3.6	-2.0	-2.0	-1.2	-2.1	-2.4	-2.1	-2.2	-1.6
Vitamin and mineral supplements	2.0	2.7	9.7	0.2	-0.5	-0.4	0.3	0.4	3.1	1.7	1.6	1.2	2.3	2.6
Supplements: Glucosamine	2.0	2.7	8.2	-0.4	-0.4	2.9	-0.5	-0.7	-2.6	-1.0	-1.9	-0.6	-2.1	-2.1
Type 2 Diabetes (T2D) (2012)	1.9	2.1	7.2	-0.7	0.1	0.4	-0.7	-0.8	-2.7	-1.6	-1.8	-1.2	-1.7	-2.1
Pulse wave Arterial Stiffness index	1.9	2.2	4.9	-0.8	-1.4	0.5	-0.9	-0.9	-0.7	-2.2	-1.7	-2.1	-1.7	-1.9
Tense / ‘highly strung’	1.9	3.1	8.4	0.3	0.4	-1.9	0.7	0.8	1.1	2.9	2.2	2.7	1.9	1.8
Ever highly irritable/argumentative for 2 days	1.9	2.2	6.9	-0.6	-2.6	-1.6	-1.5	-1.5	0.7	-1.3	-1.6	-1.4	-1.2	-1.4
Pulse wave peak to peak time	1.9	2.3	5.2	0.7	1.5	-0.5	0.8	0.9	0.7	2.3	1.8	2.2	1.8	1.9
Hearing difficulty/problems: Yes	1.8	2.7	6.5	1.4	1.2	2.4	1.2	1.2	1.0	2.3	1.1	2.6	1.2	1.4
Diabetes (father)	1.8	2.3	5.8	-1.1	-0.9	0.2	-1.1	-1.1	-1.0	-1.4	-2.4	-1.2	-2.4	-2.1
Supplements: Calcium	1.8	1.9	7.8	-1.2	1.5	-1.0	-1.4	-1.3	-2.8	-0.2	-1.1	-0.1	-1.4	-1.4
Maternal smoking around birth	1.7	2.5	5.4	-1.3	-2.3	-1.7	-1.2	-1.2	0.2	-2.1	-1.3	-2.3	-1.1	-1.3
Pulse wave reflection index	1.7	2.2	4.6	0.4	-0.0	0.5	-0.3	-0.3	-2.1	-2.1	-1.5	-2.0	-1.9	-2.1
Number of children fathered	1.7	1.9	4.6	-1.2	-0.8	-0.0	-1.7	-1.7	-0.8	-1.9	-1.3	-2.2	-1.1	-1.3
Blood Red Count	1.6	15.0	104.0	1.5	1.6	10.2	2.0	2.0	1.7	3.0	2.5	2.8	3.4	3.3
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	4.4	-0.2	-1.0	-1.3	-0.4	-0.4	-1.5	-1.3	-1.7	-1.1	-1.7	-2.1
Osteoarthritis (self-reported)	1.6	2.1	4.4	-1.8	-2.1	-0.0	-2.1	-2.1	0.3	-1.0	-1.3	-1.2	-1.2	-0.9
Medication: Bendroflumethiazide	1.6	2.4	4.5	2.1	0.5	-1.2	1.4	1.4	0.7	2.1	1.7	2.1	1.2	1.5
Basal cell carcinoma (self-reported)	1.6	1.9	3.1	1.7	1.8	0.4	1.4	1.4	0.4	1.4	1.2	1.4	1.5	1.7
Alzheimer’s Disease (in father)	1.5	1.6	3.1	-0.9	-0.0	-1.6	-1.0	-1.1	-1.0	-1.8	-1.4	-1.8	-1.1	-1.3
Mean Putamen Volume	1.5	1.8	5.7	-0.6	-1.5	2.4	-0.8	-0.8	-0.7	-1.1	-1.0	-1.1	-1.6	-1.8
Relative age voice broke	1.5	2.3	4.5	-1.9	-2.1	-2.1	-1.7	-1.7	0.6	-1.0	-1.5	-1.1	-0.8	-1.1
Noisy workplace	1.5	1.8	3.6	-1.9	-0.8	0.2	-1.8	-1.9	0.4	-1.2	-1.8	-1.4	-0.8	-1.0
Illnesses of father: None of the above (group 1)	1.5	1.8	6.5	1.2	2.5	-0.4	1.2	1.2	-1.2	1.4	1.1	1.6	0.8	0.9
Average weekly champagne plus white wine intake	1.5	2.0	4.6	-2.1	-1.1	-0.8	-1.7	-1.7	-0.6	-1.3	-1.2	-1.5	-1.4	-1.5
Worry (Nagel 2018)	1.4	2.8	4.3	1.6	0.9	-1.6	1.9	2.1	1.1	1.5	2.1	1.6	1.7	1.9
Crohns Disease (2017)	1.4	3.0	8.3	-1.6	1.5	0.7	-0.8	-1.2	-2.9	-2.4	-1.1	-2.4	-1.5	-1.5
Coronary Artery Disease (CAD)	1.4	1.7	4.7	1.6	2.2	-0.4	1.1	1.4	-1.7	1.4	0.8	1.7	0.2	0.4
Average weekly spirits intake	1.4	1.7	5.2	1.4	0.6	2.3	1.4	1.4	0.7	1.4	1.1	1.5	0.6	1.2
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	4.2	-0.2	2.0	1.0	0.2	0.3	0.8	1.5	1.1	1.2	1.8	1.8
Medication: Ramipril	1.4	1.8	3.6	-0.9	-0.5	0.5	-1.0	-1.1	-1.4	-1.7	-1.8	-1.5	-1.9	-1.6
Number of full brothers	1.4	1.8	4.0	-1.7	-2.0	0.4	-1.9	-1.9	0.5	-0.6	-1.6	-0.8	-0.9	-1.1
Number of full sisters	1.4	1.7	3.3	-1.1	-1.1	1.1	-1.2	-1.2	-0.9	-1.6	-1.3	-1.5	-1.5	-1.8
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.8	0.7	1.3	-0.4	1.2	1.2	0.8	1.9	1.3	1.9	1.0	1.7
Bipolar Disorder (2018)	1.3	2.0	5.4	-0.2	0.2	-2.3	-0.3	-0.4	-1.9	-1.6	-1.3	-1.5	-1.9	-1.8
Ulcerative Colitis (UC)	1.3	2.4	7.1	0.5	1.4	0.2	1.0	0.8	1.4	1.6	1.8	1.1	2.7	2.5
Verbal and Numeric Reasoning (VNR)	1.3	3.1	15.0	1.0	2.1	3.9	1.4	1.4	0.4	1.0	1.1	1.1	1.9	1.7
Crohns Disease (2012)	1.3	2.2	9.0	-0.5	1.8	0.2	-0.2	-0.3	-3.0	-1.9	-0.9	-1.9	-1.1	-1.4
Had other major operations	1.3	1.6	3.4	-1.3	-1.5	0.4	-1.1	-1.0	-0.8	-0.8	-1.7	-0.7	-1.7	-1.8
Wheeze or whistling in the chest in last year	1.3	2.3	5.3	-1.1	-0.9	-2.3	-1.8	-1.8	-0.5	-1.4	-1.6	-1.5	-1.6	-1.2
Leg pain on walking	1.3	1.6	4.0	-2.0	-0.7	-1.5	-1.9	-1.9	0.2	-0.6	-1.3	-0.8	-0.8	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	3.1	1.8	0.7	1.4	1.5	1.4	0.3	1.5	0.7	1.7	0.7	1.0
Mineral and other dietary supplements	1.3	1.8	9.6	-0.1	-1.0	-0.3	0.4	0.5	3.1	-0.2	1.4	-0.6	1.6	1.7
Commuting to job workplace: Public transport	1.3	1.5	6.4	0.8	0.9	1.3	0.6	0.6	-2.5	-1.2	-1.4	-0.6	-1.0	-1.4
Bipolar Disorder (2011)	1.2	1.2	4.8	1.1	1.5	-2.2	0.7	0.6	-1.9	0.0	0.0	0.0	0.0	0.0
Angina	1.2	1.5	3.1	-1.2	-1.8	-1.6	-1.3	-1.4	-0.2	-0.6	-1.3	-0.8	-1.0	-1.5
Hearing difficulty/problems with background noise	1.2	1.9	6.3	1.0	1.3	2.5	0.6	0.7	0.3	2.1	0.8	2.3	0.4	0.8
Health satisfaction	1.2	1.6	3.6	-1.2	-1.7	-0.3	-1.1	-1.1	-0.6	-1.1	-1.9	-1.1	-1.4	-1.6
Angina (self-reported)	1.2	1.6	3.8	-1.0	-1.9	-1.6	-1.3	-1.3	-0.2	-0.7	-1.3	-0.8	-1.0	-1.6
Friendships satisfaction	1.2	1.4	2.5	0.9	1.1	0.0	1.3	1.3	0.5	1.2	1.5	1.3	1.4	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	7.1	-2.4	-2.7	-0.3	-2.4	-2.3	1.5	-0.5	-0.5	-1.0	-0.8	-0.6
Illnesses of father: High blood pressure	1.2	1.5	4.0	0.3	-1.7	-0.2	0.0	-0.0	-0.9	-1.8	-1.3	-1.4	-1.4	-2.0
Depressed Affect (Nagel 2018)	1.1	2.4	6.2	-0.7	0.7	-0.8	-0.4	-0.2	2.2	2.0	1.6	1.5	2.1	2.5
Type 2 Diabetes (T2D) (2018)	1.1	2.1	6.2	-0.7	-2.5	1.5	-0.8	-0.9	1.5	-1.9	-1.4	-2.3	0.0	-0.2
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.8	0.5	-0.9	1.2	0.4	0.5	2.2	1.0	1.1	0.8	1.5	1.4
Exposure to tobacco smoke outside home	1.1	1.4	3.2	-1.1	-1.8	-1.0	-1.2	-1.2	0.1	-1.3	-0.9	-1.4	-1.0	-1.4
Age started oral contraceptive pill	1.1	1.3	4.4	0.5	1.8	0.6	0.4	0.5	-0.9	2.0	0.1	2.1	0.6	1.1
Primary Biliary Cirrhosis	1.0	1.5	6.9	0.3	2.6	-0.7	0.2	0.2	-1.5	1.5	0.8	1.7	0.4	0.8
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.4	-1.3	-0.0	-1.1	-1.9	-1.8	0.1	-1.2	-1.0	-1.4	-0.8	-0.6
Supplements: Zinc	1.0	1.1	4.7	0.1	1.2	-0.2	0.7	0.7	-1.1	1.8	0.4	2.2	-0.0	-0.0
Time employed in main current job	1.0	1.2	3.0	-1.7	-1.3	-0.9	-1.4	-1.5	-0.4	-0.3	-1.3	-0.4	-0.6	-0.9
Medication: Omeprazole	1.0	1.1	3.1	0.7	-1.0	0.7	0.4	0.2	-1.0	-0.9	-1.7	-0.3	-1.7	-1.6
Commuting to job workplace: Car/motor vehicle	1.0	1.2	4.3	0.2	-0.3	-0.3	0.2	0.2	2.1	1.5	1.4	1.2	1.1	1.3
Diabetes diagnosed by doctor	1.0	1.7	4.8	-1.0	-2.0	0.9	-1.1	-1.1	1.4	-1.7	-1.0	-2.2	-0.0	-0.1
Alcohol drinker status: Previous	1.0	1.2	4.7	2.2	0.2	2.0	1.2	1.3	0.2	0.2	1.0	0.4	0.3	0.2
Breast Cancer	0.9	2.1	8.0	1.1	2.3	0.9	1.7	1.6	-2.8	-0.1	-0.0	0.8	-0.9	-0.5
HbA1C	0.9	1.0	4.3	-0.7	0.3	-2.1	-0.5	-0.6	-1.1	-0.5	-1.5	-0.4	-0.9	-1.0
Heel T-Score	0.9	7.5	13.0	2.4	2.4	2.7	3.6	3.6	0.2	2.6	2.9	2.9	2.9	2.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.6	1.0	1.2	0.2	1.4	1.5	1.1	1.8	1.7	1.9	1.1	1.9
High blood pressure (mother)	0.9	1.3	3.6	-0.0	-1.9	-1.6	-0.4	-0.4	-0.2	-1.2	-0.6	-1.1	-1.6	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.9	0.8	1.3	-0.5	1.2	1.2	1.2	2.1	1.5	2.2	1.1	1.9
Falls in the last year	0.9	1.3	2.9	0.1	1.0	-0.7	-0.4	-0.4	-1.7	-1.4	-1.6	-1.1	-1.5	-1.1
Birth weight of first child	0.9	1.6	2.5	-1.4	-1.4	-1.1	-1.3	-1.2	-0.1	-1.3	-1.4	-1.4	-1.3	-1.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	5.2	-1.5	-2.3	0.9	-1.4	-1.4	2.0	-0.8	0.6	-1.4	0.4	0.2
Shortness of breath walking on level ground	0.9	1.1	3.7	-1.6	-0.9	0.2	-1.4	-1.3	1.9	0.3	-0.4	-0.2	0.7	0.5
Eye problems/disorders: None of the above	0.9	1.0	4.0	0.8	2.0	-1.5	0.6	0.7	-1.8	-0.2	-0.0	0.1	-0.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.8	0.2	-1.1	0.3	-0.6	-0.6	-0.7	-1.3	-1.6	-1.3	-1.0	-1.7
Overall health rating	0.9	2.0	4.2	0.0	-0.8	-1.1	-0.6	-0.6	-1.5	-2.0	-1.3	-1.7	-2.1	-2.0
Loneliness, isolation	0.9	1.2	3.1	-1.7	-1.5	1.2	-1.4	-1.4	1.1	-0.5	-0.9	-0.7	-0.1	-0.1
Smoking status: Current	0.9	1.4	5.5	-1.6	0.2	-2.3	-1.4	-1.4	-0.3	-0.5	-1.2	-0.8	-0.6	-0.5
Ever taken oral contraceptive pill	0.9	1.0	2.2	1.3	-0.0	-0.5	1.4	1.3	0.5	1.0	1.5	1.2	0.7	0.6
Average weekly beer plus cider intake	0.9	1.3	6.2	-0.3	-1.3	-2.5	-1.4	-1.3	1.3	-0.5	-0.6	-0.7	-0.4	-0.3
Schizophrenia vs Biploar Disorder	0.8	1.0	3.4	-0.9	-0.2	0.7	-0.2	-0.0	1.8	1.0	0.8	0.7	1.7	1.3
Relative age of first facial hair	0.8	1.7	3.6	-1.7	-1.8	-1.9	-1.3	-1.3	0.9	-1.0	-1.2	-1.0	-0.7	-0.9
Ever had hysterectomy (womb removed)	0.8	0.9	3.4	1.4	1.8	0.3	1.1	1.1	-0.8	0.5	0.5	0.6	0.5	0.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	0.6	-0.2	0.5	0.7	0.5	1.2	1.2	1.4	1.1	0.8	1.1
Current tobacco smoking	0.8	1.2	4.2	-1.6	0.2	-2.0	-1.4	-1.4	-0.1	-0.5	-1.2	-0.8	-0.6	-0.5
Fed-up feelings	0.8	1.4	3.2	-1.8	-0.7	-1.1	-1.3	-1.2	1.7	0.8	1.0	0.3	1.1	1.1
Number of incorrect matches in round	0.8	1.4	11.0	0.4	1.0	-3.3	0.3	0.3	-1.5	-0.2	-0.5	0.0	-0.2	-0.5
Forced vital capacity (FVC)	0.8	3.2	7.3	-2.7	-2.3	-1.2	-2.3	-2.3	0.4	-1.5	-0.7	-1.9	-1.2	-1.7
Allergy	0.8	1.8	11.8	-0.6	-1.7	3.4	-0.3	-0.3	2.0	0.3	0.1	0.0	0.6	0.3
Fluid intelligence score	0.8	1.6	5.6	1.5	0.8	2.4	1.6	1.6	0.8	0.1	0.8	0.3	1.0	1.0
Illnesses of mother	0.8	1.0	2.3	1.0	1.1	-0.5	1.1	1.1	0.2	0.9	1.1	0.9	1.5	1.1
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.2	0.9	1.7	-0.5	0.2	0.3	0.3	1.0	0.8	1.0	1.0	1.8
Age at first live birth	0.8	1.5	3.5	0.5	1.8	-0.3	0.4	0.5	-0.2	1.9	1.6	1.6	1.1	1.4
Mood swings	0.8	1.5	3.5	-0.5	0.3	-1.9	-0.3	-0.1	1.5	1.6	1.5	1.1	1.3	1.4
Medication: Gliclazide	0.8	0.9	2.1	-0.9	-1.1	0.3	-0.9	-0.9	1.5	-1.0	-0.4	-1.4	0.4	0.5
Commuting to job workplace: Cycle	0.8	1.0	2.8	0.9	1.2	0.6	0.9	0.9	0.2	0.5	1.7	0.5	1.4	1.3
Intelligence (Savage-Jansen 2018)	0.7	2.1	18.1	0.6	1.4	4.3	0.7	0.7	0.0	0.2	0.7	0.2	0.7	0.7
Prostate Cancer	0.7	0.9	3.4	-1.3	-1.3	0.4	-0.8	-0.8	1.8	-0.5	-0.7	-0.9	0.6	-0.0
Neuroticism (2016)	0.7	1.0	4.3	-0.5	-0.0	0.2	0.4	0.4	2.1	0.7	1.2	0.3	1.6	1.4
Medication: Levothyroxine sodium	0.7	1.2	4.6	-1.4	-2.1	0.5	-1.3	-1.2	1.7	-0.1	0.1	-0.5	0.2	0.2
Diabetes (self-reported)	0.7	1.1	3.1	-0.9	-1.5	0.8	-0.9	-1.0	1.0	-1.4	-0.9	-1.8	-0.2	0.0
Number of live births	0.7	1.0	4.2	0.5	-0.4	-2.1	-0.1	-0.1	-0.8	-1.5	-0.7	-1.2	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	5.1	-2.3	-2.0	-0.7	-2.2	-2.2	0.2	-1.4	-0.8	-1.7	-1.0	-1.4
Pulse rate	0.7	1.3	6.5	-1.2	-1.5	0.2	-0.9	-0.9	2.6	0.3	-0.1	-0.2	0.9	1.1
Happiness	0.7	0.8	3.8	-0.6	1.9	-0.6	-0.3	-0.2	-0.8	1.2	0.2	1.0	0.7	0.8
Mouth/teeth dental problems: Dentures	0.7	1.1	3.4	-1.2	-1.4	0.4	-1.4	-1.3	1.8	-0.6	-0.4	-0.9	-0.3	0.1
Depression (self-reported)	0.7	0.8	2.3	-1.4	-0.5	-0.9	-0.8	-0.8	-0.1	-0.5	-1.5	-0.4	-1.0	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.3	-1.0	-1.2	-1.2	-1.0	-0.9	-0.5	-0.3	-1.5	-0.4	-1.3	-1.1
Glaucoma (self-reported)	0.7	0.9	4.5	-0.0	-2.1	0.8	-0.2	-0.2	1.9	-0.1	-0.1	-0.3	0.3	-0.4
Medication: Blood pressure	0.7	1.2	4.1	2.0	0.5	-0.4	1.4	1.4	0.3	0.6	1.6	0.6	0.8	0.9
Alcohol intake frequency.	0.7	1.5	6.9	-1.3	-0.7	2.6	-1.7	-1.6	1.0	0.7	-0.3	0.2	0.3	0.6
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.7	-1.3	-0.5	-0.9	-1.1	-1.2	0.1	-1.1	-0.7	-1.3	-0.3	-0.2
Miserableness	0.7	1.2	3.5	-0.7	0.1	-1.3	-0.7	-0.5	1.9	0.9	1.2	0.5	1.3	1.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.7	0.7	1.7	-0.4	0.5	0.6	-1.4	1.3	0.1	1.6	-0.0	0.1
Age at First Birth	0.6	0.8	3.0	-0.8	-0.2	-0.8	-0.4	-0.3	-1.2	-0.5	-0.7	-0.4	-1.7	-1.4
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	-0.4	0.5	-0.9	-0.7	-0.6	0.9	1.4	0.6	1.1	1.0	1.4
Blood Eosinophil Count	0.6	4.7	18.3	4.3	2.6	0.5	1.5	1.4	0.4	2.2	2.3	2.4	1.6	1.9
Allergy or Eczema	0.6	1.7	10.3	0.3	1.7	-3.2	-0.1	-0.1	-2.0	0.6	0.4	0.9	-0.4	-0.2
Hypothyroidism (self reported)	0.6	1.3	4.8	-1.4	-2.2	0.9	-1.2	-1.2	1.5	-0.5	0.3	-0.9	0.1	-0.2
Sensitivity / hurt feelings	0.6	1.0	5.1	-1.4	-0.6	-2.2	-0.8	-0.8	0.9	0.8	-0.2	0.6	-0.0	0.3
Hand grip strength (right)	0.6	1.5	4.5	0.8	2.1	-0.4	1.6	1.5	-0.4	1.0	1.2	1.1	1.0	1.3
Had menopause	0.6	0.8	2.6	0.3	1.6	1.6	0.5	0.4	-1.1	0.8	-0.2	1.0	0.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	4.3	-0.2	-0.1	-2.1	-0.4	-0.4	-0.6	-0.5	-1.2	-0.3	-0.8	-0.8
Financial difficulties in last 2 years	0.6	0.8	4.0	0.6	-0.3	2.0	0.2	0.3	0.7	0.7	1.2	0.7	0.8	0.7
Pain all over the body in last month	0.6	0.6	1.8	0.9	-0.3	1.3	0.3	0.3	-0.9	-0.4	-0.7	-0.1	-0.9	-1.2
Medication: Simvastatin	0.6	0.9	3.7	-0.5	-1.9	-0.7	-0.8	-0.7	1.5	-0.6	-0.4	-1.0	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.1	4.3	-2.1	-1.7	-1.1	-1.9	-1.9	0.0	-1.3	-0.4	-1.7	-0.8	-1.2
Headache pain in last month	0.6	1.0	5.7	0.3	0.0	2.4	0.6	0.4	-0.6	1.3	-0.2	1.6	-0.4	-0.1
Gout (self-reported)	0.6	0.9	1.9	-0.2	-0.2	-1.4	-0.9	-0.9	-1.1	-0.5	-0.9	-0.5	-1.4	-1.3
Suffer from ‘nerves’	0.6	1.0	10.4	-0.4	-0.3	-3.2	-0.1	-0.1	0.0	-0.2	0.1	-0.2	-0.2	-0.4
Family relationship satisfaction	0.6	0.8	2.1	0.5	0.9	-0.4	0.3	0.3	0.6	1.5	0.9	1.4	1.1	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.9	1.0	0.0	1.3	0.8	0.7	-1.0	-0.4	-0.5	-0.0	-1.4	-0.8
Average weekly red wine intake	0.6	0.9	1.8	1.3	0.1	-0.9	1.0	1.0	0.8	0.5	1.1	0.5	1.2	0.9
Myopia	0.6	0.9	3.2	1.2	1.6	-1.8	0.6	0.6	-1.0	-0.3	-0.5	-0.0	0.3	0.0
Depression (Nagel 2018)	0.5	0.7	2.0	-0.9	0.9	-0.8	-1.4	-1.3	-0.6	-0.3	-0.9	-0.4	-0.5	-0.0
Neuroticism (Nagel 2018)	0.5	1.3	2.8	-0.3	0.8	-1.4	0.2	0.4	1.0	1.7	1.0	1.5	1.2	1.6
LDL Cholesterol	0.5	0.8	2.3	-0.3	-1.1	0.4	-0.5	-0.5	-0.5	-0.7	-1.5	-0.4	-1.3	-1.4
Systolic Blood Pressure	0.5	2.4	5.0	2.2	2.0	-1.5	2.0	2.1	-1.0	0.1	2.0	0.4	1.1	0.7
Lung FVC	0.5	2.4	5.0	-2.1	-2.2	-0.1	-2.1	-2.1	1.0	-1.4	-0.6	-1.9	-0.6	-1.0
Neuroticism	0.5	1.3	4.2	-1.6	0.3	-2.1	-0.8	-0.7	1.2	1.0	0.6	0.6	1.1	1.3
Number of treatments/medications taken	0.5	0.9	2.5	1.3	1.6	-0.4	0.9	0.8	-0.9	1.1	0.4	1.4	-0.5	0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	-0.8	-0.0	1.2	-0.9	-0.9	-0.9	0.2	-1.1	0.2	-0.7	-0.8
Medication: Co-codamol	0.5	0.6	3.0	-1.1	0.5	1.7	-0.8	-0.9	-0.4	-0.3	-0.6	-0.4	0.1	-0.2
Diabetes (mother)	0.5	0.6	3.2	0.2	0.8	1.8	0.1	0.1	-1.1	0.1	-0.7	0.2	-0.7	-0.7
Pack years adult smoking proportion	0.5	0.7	2.0	-1.2	-0.7	0.0	-1.4	-1.4	0.5	-0.7	-0.3	-1.1	-0.3	0.0
Qualifications: CSEs or equivalent	0.5	0.7	2.5	-0.5	-1.6	-1.1	-0.7	-0.6	0.9	-0.6	-0.5	-0.8	-0.6	-0.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	4.3	0.5	1.8	-2.1	0.2	0.3	-1.4	0.6	0.8	0.6	0.5	0.5
Sitting height	0.5	3.7	11.2	-3.3	-1.2	-2.3	-2.6	-2.6	-1.1	-0.4	-1.3	-0.5	-1.8	-1.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-0.7	-0.5	1.1	-1.0	-1.0	0.6	-0.4	-1.0	-0.8	-0.3	0.0
Alcohol intake versus 10 years previously	0.5	0.8	2.0	-0.2	0.6	-1.3	-0.5	-0.5	-1.4	-1.0	-0.2	-1.0	-1.1	-0.8
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.6	-1.0	-0.2	-0.5	-0.6	-0.6	-1.1	-1.6	-1.3	-1.5	-1.0	-1.1
Medication: Cholesterol lowering	0.5	0.7	1.2	0.7	0.4	0.5	0.6	0.7	1.0	1.1	0.8	1.0	1.1	1.0
Hair/balding pattern: Pattern 4	0.5	1.1	5.0	-0.5	0.3	2.2	0.1	0.2	0.9	1.0	1.2	0.8	1.1	1.3
Birth weight	0.5	1.0	2.3	0.1	0.0	-0.9	-0.5	-0.6	-1.4	-1.3	-0.9	-1.0	-1.5	-1.3
Forced vital capacity (FVC), Best measure	0.5	1.9	4.5	-2.1	-1.5	-1.8	-1.5	-1.6	-0.2	-1.2	-0.1	-1.5	-0.9	-1.4
Heart disease (mother)	0.5	0.6	1.3	-0.9	-0.3	0.1	-1.1	-1.1	-0.4	-0.8	-0.6	-0.9	-1.1	-0.8
Age at last live birth	0.5	0.7	1.7	0.1	1.3	-0.9	-0.2	-0.2	-0.4	1.2	1.1	0.9	0.9	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.0	-0.4	-0.4	-1.4	-0.3	-0.2	1.2	0.8	1.0	0.5	0.9	0.8
Illnesses of father: Heart disease	0.5	0.7	2.2	0.2	-0.2	-0.4	-0.0	-0.0	1.0	1.0	1.4	0.7	1.5	1.1
Commuting to job workplace: Walk	0.5	0.5	1.0	-0.7	-0.3	-0.7	-0.6	-0.7	-0.9	-0.5	-0.6	-0.4	-1.0	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.9	0.5	0.6	-1.0	0.6	0.5	-1.4	-1.2	-0.9	-0.8	-0.8	-1.1
Medication for cholesterol	0.5	0.8	1.5	0.3	1.2	0.5	0.9	0.9	0.1	0.8	1.1	0.9	1.1	1.2
Osteoporosis (self-reported)	0.5	0.6	1.5	0.7	0.9	-0.7	0.0	0.0	0.3	0.4	1.2	0.3	1.2	1.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.5	-0.2	-0.0	-1.6	-0.8	-0.8	-0.6	-0.9	-1.0	-0.8	-0.5	-0.3
Fractured/broken bones in last 5 years	0.5	0.7	1.4	-0.4	-0.2	-1.1	-0.6	-0.7	-0.5	-1.0	-0.7	-0.8	-1.2	-1.1
Ever depressed for a whole week	0.5	0.6	1.3	-0.8	-1.0	-1.1	-0.9	-0.8	-0.1	0.0	-1.0	0.1	-1.0	-0.9
Bipolar Disorder or Schizophrenia	0.4	1.0	4.1	-0.1	0.8	-2.0	-0.1	-0.1	-1.5	-0.7	-0.5	-0.6	-1.2	-1.1
Reaction Time	0.4	0.8	3.4	1.1	1.6	0.4	0.5	0.5	-1.8	-0.1	-0.3	0.1	-0.9	-0.4
Triglycerides	0.4	0.7	1.5	-0.6	-0.5	-0.2	-0.4	-0.6	-0.5	-1.0	-1.0	-1.0	-1.2	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	-0.9	0.3	0.9	-1.2	-1.1	0.6	-0.6	-0.3	-0.8	-0.0	0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.3	0.9	1.0	0.5	0.7	0.6	-1.2	0.1	-0.3	0.2	0.3	-0.1
Heart attack	0.4	0.5	4.2	0.3	0.4	-2.0	0.2	0.2	-0.5	-0.4	-0.2	-0.4	0.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	0.2	0.1	-0.7	0.4	0.5	1.0	0.8	0.7	0.5	1.1	0.8
Illnesses of siblings	0.4	0.5	1.1	0.5	1.0	0.4	0.8	0.8	0.3	0.6	0.5	0.6	0.9	1.0
Neuroticism score	0.4	0.9	2.0	-1.1	-0.0	-1.2	-0.4	-0.3	1.4	1.0	1.0	0.7	1.0	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.8	0.0	0.3	1.7	0.4	0.4	0.2	-1.1	-0.7	-1.2	0.1	-0.1
Medication: Paracetamol	0.4	0.6	1.5	0.4	-0.3	-0.6	0.3	0.2	-1.2	-1.0	-0.7	-0.7	-1.2	-1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.1	-0.9	-0.6	-0.8	-0.6	-0.7	-0.6	-0.9	-1.0	-0.8	-0.8	-0.9
Worry too long after embarrassment	0.4	0.6	1.6	0.3	1.3	1.3	0.5	0.5	-1.1	0.7	0.2	0.9	0.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.2	-0.0	0.4	-0.2	0.4	0.4	0.5	0.7	0.9	0.6	1.0	1.1
Medication: Ibuprofen	0.4	0.5	1.7	1.0	-0.2	-0.6	0.4	0.4	1.3	0.7	0.3	0.8	0.4	0.6
Mean time to correctly identify matches	0.4	0.8	3.1	0.7	1.8	0.7	0.3	0.4	-1.4	0.9	-0.5	1.0	-0.3	0.1
Knee pain experienced in last month	0.4	0.6	1.5	-0.9	-1.0	-0.8	-1.1	-1.1	1.2	0.4	-0.3	0.0	0.2	0.4
Smoking status: Previous	0.4	0.6	3.0	1.7	0.5	-0.5	1.2	1.2	-0.1	0.1	0.6	0.5	-0.2	0.2
Qualifications: nursing, teaching	0.4	0.7	5.5	-0.8	-0.4	2.3	-0.3	-0.1	0.7	0.2	0.1	-0.1	0.8	0.1
Back pain experienced in last month	0.4	0.7	1.6	-0.8	-1.0	-0.9	-1.3	-1.3	0.6	-0.2	-0.6	-0.3	-0.7	-0.4
Breast cancer (self-reported)	0.4	0.5	1.4	0.8	0.4	1.2	0.7	0.7	0.1	0.2	0.8	0.2	1.1	0.4
Wears glasses or contact lenses	0.4	0.4	1.6	0.6	1.3	1.0	0.6	0.6	-0.3	0.3	0.3	0.4	0.4	0.6
Eye problems/disorders: Glaucoma	0.4	0.5	3.0	0.3	-1.7	0.6	0.4	0.3	1.4	-0.0	0.3	-0.2	0.2	-0.3
Alcohol drinker status: Never	0.4	0.5	2.0	-0.1	0.6	-0.3	-0.2	-0.1	1.0	0.7	0.7	0.5	1.0	1.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.4	0.4	-1.2	0.2	0.3	0.1	-0.2	-0.5	-1.2	-0.1	-1.2	-1.1
Pack years of smoking	0.4	0.5	1.4	-1.1	-0.6	0.4	-1.1	-1.2	0.6	-0.5	-0.2	-1.0	0.1	0.3
Alzheimer’s Disease (in mother)	0.3	0.4	1.2	0.2	0.2	-0.2	0.6	0.6	1.1	-0.1	0.3	-0.2	1.0	1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.2	-0.3	-0.3	-1.1	-0.0	-0.2	0.8	-0.9	-0.4	-1.0	0.5	0.3
Irritable Bowel Disease (IBD)	0.3	0.8	4.1	-0.5	2.0	0.8	0.3	-0.0	-0.7	-0.3	0.7	-0.7	1.1	1.0
Ovarian Cancer	0.3	0.4	1.0	1.0	0.7	-0.7	0.9	0.9	-0.8	-0.5	0.4	-0.1	-0.3	-0.2
Fasting Glucose	0.3	0.4	1.5	-0.1	1.1	-0.8	-0.2	-0.3	-1.2	-0.2	-0.5	-0.1	-0.4	-0.2
Rheumatoid Arthritis	0.3	0.4	1.8	0.3	-1.2	0.9	0.4	0.3	1.3	0.4	-0.1	0.5	-0.2	0.1
Waist Hip Ratio (WHR)	0.3	1.3	6.5	-1.0	-1.0	-0.8	-1.4	-1.3	2.5	0.7	-0.4	0.2	0.3	0.9
Smoking Status	0.3	0.7	4.7	0.8	0.6	-2.2	0.8	0.8	0.6	0.4	0.4	0.4	0.2	0.4
Lung FEV1/FVC ratio	0.3	1.7	5.3	-0.1	0.4	2.3	-0.4	-0.3	1.6	1.4	1.2	1.0	1.5	1.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.9	0.8	0.9	-1.4	0.4	0.5	-0.9	-0.1	0.0	0.0	-0.2	-0.2
Systolic blood pressure, automated reading	0.3	1.0	2.2	1.4	1.2	1.0	1.5	1.5	-0.9	0.0	0.9	0.3	0.5	0.1
Medication for hormone replacement therapy	0.3	0.3	1.0	-0.3	-0.2	0.5	-0.3	-0.2	0.9	0.6	0.3	0.5	1.0	0.5
Taking other prescription medications	0.3	0.5	1.4	0.7	0.4	-0.3	0.6	0.6	-1.2	0.4	0.1	0.7	-1.2	-0.7
Age when periods started (menarche)	0.3	0.8	2.3	0.8	0.7	-1.5	0.7	0.8	-0.8	1.1	0.8	1.3	0.7	0.2
High blood pressure	0.3	0.9	3.3	1.8	1.1	-0.4	1.3	1.2	-0.3	0.4	1.1	0.5	0.5	0.8
Waist circumference	0.3	1.1	3.3	-1.2	-1.3	0.1	-1.6	-1.6	1.8	-0.0	-0.2	-0.4	-0.3	0.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	-0.3	-0.7	-0.3	-0.9	-1.0	0.8	-0.5	-0.1	-0.8	-0.3	-0.1
Qualifications: None of the above	0.3	0.7	4.2	-0.1	-1.1	-2.1	-0.8	-0.8	0.0	0.1	-0.2	0.1	-0.6	-0.6
Mouth/teeth dental problems	0.3	0.5	1.1	0.3	1.0	-0.1	0.7	0.6	-0.5	1.0	0.4	0.9	0.7	0.6
Impedance of arm (right)	0.3	1.2	2.9	-0.2	-1.7	-1.1	-0.1	0.1	0.6	-1.5	-1.6	-1.4	-0.6	-1.3
Arm fat percentage (right)	0.3	1.0	3.8	-0.2	-2.0	0.3	-0.9	-0.9	1.8	-0.8	-0.5	-1.0	-0.2	0.1
Trunk fat-free mass	0.3	1.5	3.8	-0.9	0.9	0.4	-0.5	-0.6	0.8	1.9	1.9	1.6	1.1	1.7
Trunk predicted mass	0.3	1.5	3.6	-0.8	0.9	0.4	-0.5	-0.5	0.8	1.8	1.9	1.5	1.1	1.7
Exposure to tobacco smoke at home	0.3	0.4	0.8	-0.8	-0.4	-0.5	-0.7	-0.7	0.3	-0.9	-0.4	-0.9	-0.3	-0.1
Peak expiratory flow (PEF)	0.3	0.8	2.2	-0.7	-0.6	0.4	-0.9	-0.8	1.5	1.1	0.7	0.8	0.8	0.8
High blood pressure (siblings)	0.3	0.5	2.2	-0.2	-1.5	-0.2	-0.5	-0.6	0.2	-0.5	-0.4	-0.3	-0.8	-1.0
Arm fat-free mass (right)	0.3	1.4	3.3	-0.7	1.3	0.8	-0.3	-0.3	0.3	1.8	1.8	1.6	0.8	1.6
Comparative body size at age 10	0.3	0.7	1.3	-0.8	0.8	0.6	-1.0	-0.9	0.7	0.4	1.1	-0.3	1.0	1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.7	-1.3	-0.5	-0.7	-1.0	-0.9	-0.1	0.2	-0.0	0.1	0.0	-0.1
Medication: Allopurinol	0.3	0.5	1.4	1.1	0.4	-1.2	0.5	0.5	-1.1	0.2	0.0	0.3	-0.4	-0.5
Leg fat mass (right)	0.3	1.1	4.6	-0.9	-1.6	0.6	-1.1	-1.1	2.2	0.1	-0.0	-0.2	0.1	0.7
Medication: Aspirin	0.3	0.4	2.1	-0.3	0.3	-1.4	-0.2	-0.2	1.1	0.2	-0.0	-0.1	0.5	0.7
Supplements: Vitamin C	0.3	0.3	1.6	0.4	-0.6	-0.1	0.4	0.4	-0.7	-0.4	-0.4	-0.1	-0.9	-1.3
Eye problems/disorders: Cataract	0.3	0.3	1.3	-0.4	-1.1	-0.5	-0.7	-0.6	0.9	0.2	-0.2	0.1	-0.1	-0.3
Medication: Aspirin	0.3	0.4	2.9	0.1	0.1	-1.7	0.0	0.0	0.9	0.2	0.2	-0.1	0.4	0.6
Number of self-reported non-cancer illnesses	0.3	0.6	1.4	-0.2	-0.4	-1.1	-0.6	-0.6	-0.3	-0.5	-1.2	-0.4	-1.1	-1.0
Guilty feelings	0.3	0.5	1.8	-0.1	1.3	0.8	0.7	0.7	-0.7	0.7	0.2	0.6	0.5	0.5
Medication: Paracetamol	0.3	0.4	1.0	0.7	-0.7	-0.5	0.5	0.3	-0.3	-0.9	-0.5	-0.6	-1.0	-0.9
Medication: Lisinopril	0.3	0.4	1.0	1.0	0.9	-1.0	0.4	0.3	-0.7	0.1	-0.5	0.4	-0.7	-0.3
Ever smoked	0.3	0.4	1.4	1.0	1.2	-0.4	0.8	0.8	-0.3	0.6	0.3	0.7	0.1	0.5
Leg fat percentage (left)	0.3	1.2	4.2	-0.7	-2.1	0.4	-1.2	-1.1	2.1	-0.2	-0.8	-0.4	-0.3	0.2
Irritability	0.3	0.5	2.4	-1.2	0.2	-1.6	-0.7	-0.6	-0.6	-0.1	-0.1	-0.2	-0.7	-0.5
Risk taking	0.3	0.4	1.0	0.9	-0.2	-0.8	0.2	0.2	-0.9	-0.8	-0.4	-0.5	-0.4	-1.0
Ever had prostate specific antigen (PSA) test	0.3	0.4	2.1	-0.8	0.7	-1.4	-0.2	-0.2	-0.8	0.1	-0.2	0.1	0.0	-0.2
Diastolic blood pressure, automated reading	0.3	1.1	3.7	1.5	1.9	0.3	1.4	1.4	-1.3	-0.0	0.4	0.4	0.1	0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	3.7	0.1	0.2	-1.9	-0.0	-0.0	-0.2	-0.5	-0.3	-0.4	0.0	-0.2
Leg fat mass (left)	0.3	1.1	3.8	-1.1	-1.7	0.7	-1.4	-1.4	1.9	0.0	-0.2	-0.3	-0.1	0.5
HDL Cholesterol	0.2	0.4	1.0	1.0	0.3	-0.7	0.8	0.9	-0.1	-0.3	0.6	-0.3	0.6	0.2
Schizophrenia (2014)	0.2	0.5	1.9	0.2	1.1	-1.4	0.6	0.7	-0.4	0.6	0.4	0.7	0.2	0.1
Blood Platelet Count	0.2	2.9	6.0	-1.0	-2.4	-0.0	-1.3	-1.4	0.5	-2.4	-1.9	-2.4	-1.4	-1.8
Blood White Count	0.2	1.2	3.5	-0.2	-0.0	1.9	-0.1	-0.1	1.4	1.6	1.3	1.4	0.6	1.1
Height	0.2	3.0	8.1	-2.8	-0.2	1.7	-0.8	-0.7	2.6	2.0	1.4	1.4	1.6	1.8
Hand grip strength (left)	0.2	0.6	2.0	0.3	1.4	-0.9	0.9	0.9	-0.7	0.5	0.7	0.7	0.3	0.5
Medication: Metformin	0.2	0.3	1.6	-0.0	-0.7	-0.6	-0.1	-0.1	0.3	-1.1	0.2	-1.2	0.0	0.3
Trunk fat percentage	0.2	0.8	4.0	-0.6	-1.5	0.2	-1.0	-0.9	2.0	0.1	-0.3	-0.1	-0.1	0.4
Townsend deprivation index at recruitment	0.2	0.2	1.1	-0.3	-0.6	0.6	-0.5	-0.4	1.0	0.2	0.4	0.1	0.3	0.3
Average weekly fortified wine intake	0.2	0.2	1.2	0.2	0.4	-1.1	0.1	0.0	-0.4	0.1	-0.4	0.3	-0.3	0.2
Stomach or abdominal pain in last month	0.2	0.2	0.8	0.1	-0.4	0.9	-0.0	-0.0	0.0	-0.6	-0.9	-0.4	-0.1	-0.5
Medication: Atenolol	0.2	0.3	1.1	1.1	-0.1	-0.0	0.6	0.6	0.2	-0.2	0.8	-0.3	0.5	-0.1
Trunk fat mass	0.2	0.8	3.7	-0.8	-1.2	0.3	-1.0	-0.9	1.9	0.5	0.2	0.2	0.1	0.7
Past tobacco smoking	0.2	0.4	2.3	-0.8	-0.3	1.5	-0.5	-0.4	0.4	0.2	0.3	0.0	0.6	0.3
Alcohol usually taken with meals	0.2	0.4	1.7	-0.3	0.6	1.3	-0.1	-0.1	0.2	0.7	0.1	0.7	0.6	0.5
Nervous feelings	0.2	0.4	2.8	-0.0	-0.8	-1.7	0.5	0.5	0.7	0.3	0.0	0.4	0.1	0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.1	-0.9	0.8	0.4	0.3	0.6	0.5	-0.4	0.6	0.2	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.0	0.3	0.0	-1.0	-0.1	-0.1	1.0	0.4	-0.4	0.4	0.2	0.4
Prospective memory result	0.2	0.3	1.4	-0.0	-0.1	-1.2	-0.2	-0.2	-0.8	-0.3	-0.5	-0.1	-0.2	-0.6
Lung cancer (father)	0.2	0.3	0.5	-0.2	0.5	0.2	-0.4	-0.5	-0.6	-0.7	-0.6	-0.7	-0.6	-0.3
Impedance of arm (left)	0.2	0.8	1.9	-0.3	-1.4	-1.2	0.2	0.3	0.5	-0.9	-1.2	-0.8	-0.5	-1.1
Arm fat mass (right)	0.2	0.8	3.5	-0.5	-1.4	0.3	-1.0	-1.0	1.9	-0.1	0.1	-0.3	0.0	0.6
Medication: Amlodipine	0.2	0.3	0.7	0.3	0.5	-0.9	-0.1	-0.1	0.5	0.2	0.8	-0.2	0.7	0.9
Body fat percentage	0.2	0.9	4.0	-0.6	-1.7	0.4	-1.0	-0.9	2.0	-0.1	-0.5	-0.3	-0.1	0.4
Leg fat percentage (right)	0.2	0.9	4.8	-0.3	-1.9	0.3	-0.6	-0.6	2.2	-0.2	-0.5	-0.3	-0.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	0.5	-0.7	0.5	1.0	1.1	0.5	0.2	0.3	0.3	0.2	-0.0
Emphysema/chronic bronchitis	0.2	0.2	0.7	0.8	-0.1	-0.4	0.8	0.8	-0.3	-0.4	0.1	-0.2	-0.2	-0.2
Whole body fat mass	0.2	0.8	4.2	-0.7	-1.3	0.4	-1.0	-0.9	2.1	0.4	0.2	0.1	0.2	0.8
Arm predicted mass (right)	0.2	1.2	2.7	-0.9	1.2	0.6	-0.5	-0.6	0.2	1.6	1.7	1.4	0.6	1.4
Comparative height size at age 10	0.2	1.1	4.9	-1.1	1.2	2.2	-0.0	-0.1	-1.3	1.1	0.1	1.4	-0.5	-0.1
Hypertension (Self-reported)	0.2	0.5	2.7	1.6	0.5	-0.6	1.0	0.9	-0.1	-0.2	0.7	-0.1	0.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.9	-0.8	-0.4	-1.4	-0.5	-0.5	-0.3	-0.1	0.5	-0.1	-0.5	-0.7
Whole body fat-free mass	0.2	1.1	2.9	-0.9	0.7	0.7	-0.7	-0.8	0.8	1.4	1.7	1.1	0.8	1.5
Arm fat percentage (left)	0.2	0.9	4.1	-0.3	-1.9	0.4	-0.9	-0.9	2.0	-0.5	-0.3	-0.7	-0.1	0.3
Whole body water mass	0.2	1.3	3.5	-0.8	0.8	0.8	-0.6	-0.6	0.8	1.5	1.9	1.2	0.9	1.6
Leg predicted mass (right)	0.2	0.8	2.1	-0.8	0.1	1.1	-1.0	-1.0	0.9	0.9	1.4	0.6	0.5	1.1
Arm fat mass (left)	0.2	0.8	4.2	-0.4	-1.2	0.3	-0.7	-0.7	2.1	0.1	0.5	-0.1	0.4	0.9
Mother’s age at death	0.2	0.2	0.9	0.7	0.5	1.0	0.6	0.5	-0.1	-0.3	-0.1	-0.1	-0.0	0.2
High cholesterol (Self-reported)	0.2	0.4	2.0	0.2	-1.4	-0.3	0.2	0.2	0.7	-0.4	-0.3	-0.5	-0.3	-0.8
Medication: Atorvastatin	0.2	0.3	2.2	-0.3	-0.2	-1.5	-0.5	-0.6	-0.1	-0.2	-0.5	-0.1	-0.0	-0.2
Basal metabolic rate	0.2	0.9	2.2	-0.9	0.3	0.5	-0.9	-0.9	0.9	1.1	1.5	0.8	0.6	1.3
Arm fat-free mass (left)	0.2	1.2	2.9	-0.9	1.1	0.4	-0.6	-0.6	0.6	1.6	1.7	1.3	0.8	1.7
Number of operations (self-reported)	0.2	0.3	2.2	0.0	0.3	1.5	0.5	0.5	-0.3	0.4	0.0	0.5	-0.5	-0.3
Pain experienced in last month	0.2	0.4	1.6	-0.2	1.0	-0.1	0.2	0.3	0.4	0.2	0.7	-0.0	1.3	0.9
Impedance of whole body	0.2	1.0	2.9	-0.7	-1.1	-1.6	0.0	0.2	0.2	-0.8	-1.7	-0.7	-0.7	-1.3
Arm predicted mass (left)	0.2	1.1	2.5	-0.6	1.2	0.5	-0.5	-0.5	0.3	1.6	1.6	1.4	0.6	1.6
Schizophrenia (2018)	0.1	0.2	0.9	0.1	0.9	-0.7	0.2	0.2	-0.5	0.4	0.4	0.4	-0.0	-0.0
Lupus	0.1	0.1	0.6	0.5	0.0	-0.8	0.5	0.5	0.0	0.1	-0.4	0.1	-0.0	0.2
BMI	0.1	0.4	1.6	0.3	0.1	1.3	-0.2	-0.3	0.7	0.5	0.7	0.4	0.5	1.1
Cardiovascular Disease	0.1	0.4	1.9	0.3	-0.8	-1.4	-0.4	-0.3	0.3	-0.6	-0.4	-0.6	-0.4	-0.4
Tanning	0.1	1.2	2.1	0.9	-0.0	-1.0	1.1	1.3	1.2	1.1	0.6	1.2	1.5	1.3
Impedance of leg (right)	0.1	0.6	3.1	0.0	-0.2	-1.8	1.0	1.1	0.5	0.1	-1.0	0.4	0.2	-0.2
Leg fat-free mass (left)	0.1	0.7	2.0	-0.6	0.1	1.1	-0.7	-0.7	0.9	0.7	1.4	0.5	0.6	1.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.5	0.4	0.5	-0.3	-0.3	0.3	-0.0	0.3	-0.1	0.1	0.4
Body mass index (BMI)	0.1	0.5	2.0	-0.1	-1.1	0.6	-0.8	-0.9	1.4	-0.1	0.2	-0.3	-0.0	0.7
Impedance of leg (left)	0.1	0.5	2.6	-0.5	-0.6	-1.6	0.2	0.3	0.5	0.1	-1.3	0.2	-0.2	-0.5
Leg predicted mass (left)	0.1	0.7	2.1	-0.5	0.2	1.1	-0.6	-0.6	0.9	0.8	1.4	0.5	0.6	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.9	-0.3	-0.3	0.1	-0.4	-0.3	0.9	0.5	0.1	0.5	0.4	0.5
Weight	0.1	0.7	2.3	-0.9	-0.7	0.3	-1.0	-1.0	1.5	0.5	0.7	0.3	0.3	1.0
Worrier / anxious feelings	0.1	0.2	0.6	-0.0	-0.3	-0.2	0.6	0.6	0.6	0.3	0.8	0.3	0.4	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.2	-0.1	-0.1	-0.2	-0.2	-0.3	-0.5	-0.6	-0.6	0.2	-0.3
Medication: Lansoprazole	0.1	0.1	0.3	0.1	-0.2	0.2	-0.4	-0.3	0.6	0.2	0.0	-0.0	0.3	0.5
Standing height	0.1	1.2	3.5	-1.9	0.9	-0.9	-0.5	-0.4	0.4	1.6	1.2	1.4	0.7	0.9
Length of working week for main job	0.1	0.1	0.9	-0.2	0.3	1.0	-0.3	-0.4	0.4	0.1	0.2	-0.1	-0.2	0.2
Qualifications: College or University degree	0.1	0.4	2.2	-0.4	1.5	0.7	0.2	0.1	-0.5	-0.2	0.7	-0.3	1.0	0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	1.1	-0.6	-0.0	1.1	-0.6	-0.5	-0.7	-0.0	0.1	-0.1	0.0	-0.3
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.4	-0.1	0.2	-0.4	-0.4	-0.2	0.1	0.1	0.1	-0.5	-0.1
Pulse rate, automated reading	0.1	0.4	1.0	-0.7	-1.0	-0.4	-0.8	-0.8	0.8	-0.2	-0.2	-0.4	-0.3	0.0
Chest pain or discomfort	0.1	0.2	0.7	0.2	0.0	0.7	-0.2	-0.2	0.0	0.2	-0.9	0.4	-0.3	-0.4
Had major operations	0.1	0.1	0.3	0.1	0.6	0.4	0.5	0.5	0.3	-0.3	0.5	-0.2	-0.1	0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.7	0.3	-0.0	0.3	-0.1	0.0	-0.8	-0.2	-0.0	-0.2	-0.3	-0.6
Leg fat-free mass (right)	0.1	0.8	1.6	-0.9	-0.0	1.1	-1.1	-1.1	0.8	0.7	1.3	0.4	0.4	0.9
Medication: Blood pressure	0.1	0.3	0.8	0.2	-0.3	-0.9	-0.4	-0.5	-0.1	-0.5	-0.6	-0.5	-0.6	-0.3
Unable to work because of sickness or disability	0.1	0.2	0.4	0.6	-0.6	-0.6	-0.2	-0.1	0.3	-0.2	-0.1	-0.1	-0.7	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.4	-1.1	-0.0	1.2	-0.5	-0.5	0.2	0.1	-0.5	0.0	0.0	-0.0
Heart disease (siblings)	0.1	0.1	0.4	-0.2	-0.5	0.7	0.0	-0.0	-0.1	-0.2	0.0	-0.1	-0.6	-0.7
Chronotype (morning person)	0.0	0.1	0.3	0.2	-0.6	-0.1	0.2	0.1	-0.2	-0.4	0.2	-0.3	-0.3	-0.3
Hair Pigment	0.0	1.2	3.6	-0.0	-0.5	1.3	-0.6	-0.6	1.9	1.2	1.4	0.8	1.0	1.1
Hip circumference	0.0	0.2	0.7	-0.2	-0.4	0.2	-0.5	-0.5	0.8	0.3	0.6	0.2	0.0	0.5
Blood clot in the leg (DVT)	0.0	0.0	0.2	-0.4	0.1	-0.1	-0.2	-0.1	-0.1	-0.3	0.0	-0.2	0.1	0.0
Long-standing illness, disability or infirmity	0.0	0.0	0.1	0.3	0.0	-0.3	0.0	-0.0	-0.1	0.2	0.1	0.2	-0.2	0.0
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.2	-0.4	-0.3	0.1	-0.1	-0.1	0.2	-0.4	-0.0	-0.3	0.1	-0.1

Hub : Genes

TMEM189

Models

Trait associations