TWAS hub - FAM65C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.157	0.055	0.0032	0.060	NA	0.037	NA	0.039	0.00082	NA	0.0071	NA	0.0057
2	GTEx	Testis	0.255	0.078	0.0022	-0.005	NA	0.000	NA	-0.005	0.67000	NA	0.3100	NA	0.6800

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Red Count	9.4	90.6	153.8	-12.4	-5.2
Major Depression (MDD)	6.4	7.8	13.8	3.7	1.4
Number of full sisters	5.5	6.7	8.1	-2.8	-2.3
Friendships satisfaction	5.5	6.9	10.8	-3.3	-1.7
Health satisfaction	5.0	6.4	8.9	-2.0	-3.0
Mouth/teeth dental problems: Bleeding gums	4.8	6.2	10.5	-1.4	-3.2
Chronic bronchitis/emphysema (mother)	4.6	5.4	7.0	1.9	2.6
Angina (self-reported)	4.3	5.6	11.2	3.4	0.1
Serious illness, injury or assault to yourself	4.0	4.8	7.4	2.7	1.5
Prostate Cancer	3.8	5.4	9.1	1.3	3.0
Blood White Count	3.5	25.9	40.6	-6.4	-3.4
Angina	3.4	4.5	9.0	3.0	0.1
Hair/balding pattern: Pattern 2	3.4	4.3	5.9	1.6	2.4
Medication: Seretide 50 evohaler	3.1	3.6	6.7	2.6	0.7
Migraine (self-reported)	2.8	3.5	6.3	-0.8	-2.5
Medication: Ramipril	2.7	3.4	6.5	-0.7	-2.5
Breast Cancer	2.6	6.2	6.3	-2.5	-2.5
Ever highly irritable/argumentative for 2 days	2.6	3.1	4.5	1.3	2.1
Guilty feelings	2.6	3.9	6.7	-2.6	1.0
Severe depression (siblings)	2.5	2.8	3.7	1.4	1.9
Breast cancer (self-reported)	2.5	3.0	5.3	0.8	2.3
Unable to work because of sickness or disability	2.5	3.3	6.4	2.5	-0.3
Commuting to job workplace: Public transport	2.4	2.9	4.5	-2.1	1.2
Had major operations	2.3	2.7	3.3	1.4	1.8
Rheumatoid Arthritis	2.2	3.0	5.9	-2.4	-0.3
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	5.1	-2.3	-1.3
Intelligence (Savage-Jansen 2018)	2.1	6.3	7.4	-2.3	-2.7
Qualifications: nursing, teaching	2.1	3.3	5.4	-2.3	1.1
Alzheimer’s Disease (in father)	2.0	2.2	4.3	2.1	0.4
Type 2 Diabetes (T2D) (2012)	2.0	2.3	2.4	-1.6	-1.5
Lung cancer (father)	2.0	2.3	3.3	1.2	-1.8
Emphysema/chronic bronchitis	2.0	2.2	4.1	-0.6	-2.0
Comparative height size at age 10	2.0	10.8	12.4	-3.0	-3.5
Osteoporosis (self-reported)	2.0	2.5	2.9	1.5	1.7
Crohns Disease (2017)	1.9	4.1	4.1	-2.0	-2.0
Irritable Bowel Disease (IBD)	1.9	4.5	5.3	-1.9	-2.3
Happiness	1.9	2.3	3.1	-1.8	-1.2
Supplements: Fish oil (including cod liver oil)	1.9	2.5	4.8	0.3	2.2
HbA1C	1.8	1.9	2.0	-1.4	-1.4
Hand grip strength (right)	1.8	4.8	7.8	-2.8	-1.3
Number of self-reported non-cancer illnesses	1.8	3.1	4.0	2.0	1.5
Ever depressed for a whole week	1.8	2.2	4.4	-0.1	2.1
Verbal and Numeric Reasoning (VNR)	1.7	4.0	4.6	-2.1	-1.8
Coronary Artery Disease (CAD)	1.7	2.0	2.0	-1.4	-1.4
Hair/balding pattern: Pattern 3	1.7	2.6	2.8	-1.5	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	5.0	-0.6	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	2.8	-1.0	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.5	1.9	0.8
Pain all over the body in last month	1.5	1.6	3.1	-1.8	-0.4
Leg fat-free mass (right)	1.5	7.8	8.2	-2.9	-2.7
Eye problems/disorders: Cataract	1.5	1.7	2.2	1.1	1.5
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	2.9	0.8	-1.7
Trunk predicted mass	1.4	8.0	8.6	-2.9	-2.7
Arm fat-free mass (right)	1.4	7.2	8.3	-2.9	-2.5
Arm predicted mass (right)	1.4	7.1	7.4	-2.7	-2.6
Whole body fat-free mass	1.4	7.9	8.1	-2.8	-2.8
Leg predicted mass (right)	1.4	7.4	7.7	-2.8	-2.7
Financial situation satisfaction	1.4	1.8	3.6	-1.9	0.1
Risk taking	1.4	2.1	3.9	0.5	2.0
Diastolic blood pressure, automated reading	1.4	4.4	7.9	-2.8	-0.9
Alzheimer’s Disease (including proxy)	1.3	1.9	3.2	1.8	-0.9
Hand grip strength (left)	1.3	3.5	6.7	-2.6	-0.6
Diabetes (mother)	1.3	1.7	3.4	1.9	0.1
Hayfever, allergic rhinitis or eczema	1.3	2.9	5.8	0.1	2.4
Trunk fat-free mass	1.3	7.4	8.0	-2.8	-2.6
Worry too long after embarrassment	1.3	2.2	4.4	-2.1	-0.2
Whole body water mass	1.3	7.6	7.7	-2.7	-2.8
High cholesterol (Self-reported)	1.3	2.3	4.5	2.1	0.2
Arm predicted mass (left)	1.3	6.8	6.9	-2.6	-2.6
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.0	1.7	0.2
Hearing difficulty/problems with background noise	1.2	2.0	3.2	-1.8	-0.8
Qualifications: None of the above	1.2	2.5	3.7	1.9	1.2
Worrier / anxious feelings	1.2	2.3	3.7	-1.9	-1.0
Blood clot in the leg (DVT)	1.2	1.5	2.5	1.6	0.7
Headache pain in last month	1.2	2.1	3.8	-0.7	-1.9
Glaucoma (self-reported)	1.2	1.5	2.2	-0.8	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	1.8	1.4	-1.1
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.1	1.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	2.9	0.0	-1.7
Basal metabolic rate	1.2	6.5	7.6	-2.3	-2.8
Blood Platelet Count	1.1	12.7	24.8	-5.0	-0.8
Financial difficulties in last 2 years	1.1	1.5	2.4	-1.6	-0.7
Qualifications: College or University degree	1.1	3.4	6.4	-2.5	0.6
Medication: Omeprazole	1.1	1.3	2.6	-0.2	-1.6
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.5	-1.0	-1.2
Commuting to job workplace: Car/motor vehicle	1.1	1.3	1.5	1.1	-1.2
Smoking status: Current	1.1	1.7	3.3	0.4	1.8
Average weekly beer plus cider intake	1.1	1.5	1.6	1.2	1.3
Alzheimer’s Disease (in mother)	1.0	1.2	2.2	0.3	-1.5
Leg fat-free mass (left)	1.0	5.5	5.9	-2.2	-2.4
Current tobacco smoking	1.0	1.6	3.1	0.4	1.8
Medication: Atenolol	1.0	1.2	1.9	1.4	-0.7
Leg predicted mass (left)	1.0	5.4	5.8	-2.2	-2.4
Had menopause	1.0	1.2	1.3	1.2	1.0
Had other major operations	1.0	1.2	1.5	1.0	-1.2
Allergy	1.0	2.2	3.5	-1.0	-1.9
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.2	-1.5	-1.0
Mouth/teeth dental problems: Dentures	1.0	1.6	3.2	0.2	1.8
Pulse wave reflection index	1.0	1.3	1.7	-0.9	1.3
Neck or shoulder pain in last month	1.0	1.4	1.6	-1.1	-1.3
Medication: Blood pressure	1.0	1.8	3.3	0.5	-1.8
Medication for cholesterol	1.0	1.5	2.0	1.4	1.0
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	-1.5	0.0
Arm fat-free mass (left)	1.0	5.1	5.2	-2.3	-2.2
Pain experienced in last month	1.0	1.6	2.5	1.6	0.8
Reaction Time	0.9	1.8	2.4	-1.1	-1.5
Mean Putamen Volume	0.9	1.0	1.4	-0.8	-1.2
Hearing difficulty/problems: Yes	0.9	1.4	2.8	-0.2	1.7
Impedance of leg (right)	0.9	4.1	6.5	2.6	1.3
Relative age voice broke	0.9	1.4	2.6	1.6	0.5
Fluid intelligence score	0.9	1.9	2.2	-1.5	-1.3
Standing height	0.9	8.8	10.7	-2.6	-3.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.6	-1.6	0.5
Chest pain or discomfort	0.9	1.2	1.4	-1.2	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.8	1.3	0.4
Mineral and other dietary supplements	0.9	1.2	2.3	-0.3	-1.5
Miserableness	0.9	1.6	3.0	-1.7	-0.3
Hearing aid user	0.9	1.0	2.0	0.0	-1.4
Medication: Atorvastatin	0.9	1.1	1.8	0.7	1.3
HDL Cholesterol	0.8	1.4	2.7	0.3	-1.7
Height	0.8	15.0	19.4	-4.4	-3.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.6	-0.7	1.3
Age when periods started (menarche)	0.8	1.9	3.6	1.9	0.5
Medication: Levothyroxine sodium	0.8	1.3	2.5	-0.2	-1.6
Sitting height	0.8	5.8	7.2	-2.1	-2.7
Chronic bronchitis/emphysema (father)	0.8	1.0	1.0	1.0	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	1.9	-1.3	1.4
Impedance of arm (right)	0.8	3.8	6.8	2.6	0.9
Father’s age at death	0.8	1.0	1.5	-1.2	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.2	-0.8	-1.1
Forced vital capacity (FVC), Best measure	0.8	2.8	3.3	-1.8	-1.5
Pulse rate, automated reading	0.8	2.5	2.7	-1.6	-1.5
Medication: Gliclazide	0.8	0.9	1.6	1.3	0.5
Ever taken oral contraceptive pill	0.8	0.9	1.7	1.3	0.3
Medication: Blood pressure	0.8	1.5	2.0	-1.4	-1.0
Alcohol drinker status: Never	0.8	1.0	1.9	0.0	-1.4
Supplements: Calcium	0.8	0.8	1.6	-1.3	0.2
Crohns Disease (2012)	0.7	1.1	1.5	-1.2	-0.8
Primary Biliary Cirrhosis	0.7	1.0	2.0	-1.4	-0.0
Relative age of first facial hair	0.7	1.5	3.0	1.7	0.0
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	1.2	-0.1
Vitamin and mineral supplements	0.7	1.0	2.0	0.2	-1.4
Medication: Metformin	0.7	1.1	2.0	1.4	-0.4
Townsend deprivation index at recruitment	0.7	1.0	1.9	0.3	1.4
Fed-up feelings	0.7	1.4	2.7	-1.6	0.2
High blood pressure (mother)	0.7	1.0	1.4	0.8	1.2
Neuroticism score	0.7	1.5	2.8	-1.7	0.3
Alcohol intake versus 10 years previously	0.7	1.0	1.9	1.4	0.4
Noisy workplace	0.7	0.8	1.6	0.3	1.3
Medication: Lansoprazole	0.7	0.8	1.5	0.4	-1.2
Exposure to tobacco smoke at home	0.7	0.8	1.1	-1.1	0.6
Birth weight of first child	0.7	1.3	2.6	1.6	0.3
Medication: Amlodipine	0.7	1.0	1.9	-1.4	-0.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.0	0.9	1.0
Comparative body size at age 10	0.7	1.9	2.0	-1.4	-1.3
Mean time to correctly identify matches	0.7	1.4	2.6	-0.3	-1.6
Alcohol intake frequency.	0.7	1.6	2.8	1.7	0.6
Medication: Aspirin	0.7	0.9	1.0	0.9	1.0
Commuting to job workplace: Walk	0.7	0.7	1.2	-0.5	1.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.4	-1.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.0	0.3	1.7
Impedance of whole body	0.7	3.4	5.8	2.4	0.9
Ulcerative Colitis (UC)	0.6	1.2	1.5	-0.9	-1.2
Allergy or Eczema	0.6	1.7	3.3	0.2	1.8
Trunk fat percentage	0.6	2.2	4.2	2.1	-0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.1	-1.0	-0.3
High blood pressure	0.6	1.7	2.1	-1.4	-1.2
Multivitamins +/- minerals	0.6	0.7	1.0	-1.0	0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.3	0.3	1.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.3	0.6	1.1
Arm fat percentage (right)	0.6	2.4	4.4	2.1	-0.7
Falls in the last year	0.6	0.8	1.7	1.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.7	-1.6	-0.1
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	-1.2	-0.0
Impedance of arm (left)	0.6	2.9	5.6	2.4	0.4
High blood pressure (siblings)	0.6	0.8	0.8	0.9	0.9
Body fat percentage	0.6	2.3	4.4	2.1	-0.4
Exposure to tobacco smoke outside home	0.6	0.7	1.2	-0.6	-1.1
Shortness of breath walking on level ground	0.6	0.8	1.5	-1.2	-0.0
Suffer from ‘nerves’	0.6	1.0	1.6	1.3	-0.5
Loneliness, isolation	0.6	0.8	1.1	-1.1	-0.7
Long-standing illness, disability or infirmity	0.6	1.0	1.7	1.3	-0.5
Myopia	0.6	0.8	1.3	-1.1	0.6
Neuroticism	0.5	1.2	2.3	-1.5	0.4
Supplements: Zinc	0.5	0.5	1.0	-0.2	1.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	-0.1	-1.1
Qualifications: CSEs or equivalent	0.5	0.7	1.2	1.1	-0.4
Supplements: Glucosamine	0.5	0.7	1.3	-0.2	1.1
Impedance of leg (left)	0.5	2.4	3.8	1.9	1.0
Number of incorrect matches in round	0.5	0.9	1.7	0.3	1.3
Forced vital capacity (FVC)	0.5	2.0	2.2	-1.5	-1.3
Weight	0.5	2.5	4.8	-0.4	-2.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.4	-0.4	1.2
Leg fat percentage (right)	0.5	1.6	3.2	1.8	-0.2
Age at first live birth	0.5	0.9	1.8	-1.3	-0.2
Family relationship satisfaction	0.5	0.6	0.9	-0.9	0.6
Hypertension (Self-reported)	0.5	1.4	1.9	-0.9	-1.4
Arm fat percentage (left)	0.5	2.2	3.8	1.9	-0.7
Osteoarthritis (self-reported)	0.5	0.7	1.2	0.4	-1.1
Number of operations (self-reported)	0.5	0.7	1.0	1.0	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.4	1.7	1.1	1.3
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	0.3	-1.0
Worry (Nagel 2018)	0.4	0.9	1.1	-1.0	-0.8
LDL Cholesterol	0.4	0.7	1.2	-1.1	-0.4
Smoking Status	0.4	0.8	0.9	0.9	0.9
Average weekly spirits intake	0.4	0.5	0.9	0.3	-0.9
Medication for hormone replacement therapy	0.4	0.4	0.5	0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.1	-1.1	0.9
Stomach or abdominal pain in last month	0.4	0.5	0.9	0.3	0.9
Trunk fat mass	0.4	1.6	1.7	1.2	-1.3
Past tobacco smoking	0.4	0.7	1.4	-0.1	1.2
Medication: Cholesterol lowering	0.4	0.6	1.1	1.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	1.6	-1.3	-1.1
Arm fat mass (right)	0.4	1.9	2.4	1.1	-1.6
Number of full brothers	0.4	0.6	1.0	0.3	1.0
Pulse wave peak to peak time	0.4	0.4	0.9	0.9	-0.1
Heart disease (mother)	0.4	0.5	0.7	-0.5	0.8
Whole body fat mass	0.4	1.9	1.9	1.3	-1.4
Smoking status: Previous	0.4	0.6	1.1	0.4	-1.0
Medication: Aspirin	0.4	0.5	0.9	0.9	0.3
Wears glasses or contact lenses	0.4	0.4	0.7	0.4	0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	-0.3	-0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.5	0.7	-0.7
Medication: Paracetamol	0.4	0.6	0.8	-0.9	0.6
Age at First Birth	0.3	0.4	0.5	0.7	0.5
Neuroticism (2016)	0.3	0.5	0.8	-0.9	-0.4
Schizophrenia (2014)	0.3	0.8	1.3	0.5	-1.1
Triglycerides	0.3	0.5	1.0	0.1	1.0
Ulcerative Colitis	0.3	0.5	0.8	-0.3	-0.9
Blood Eosinophil Count	0.3	2.1	3.7	-1.9	-0.7
Sensitivity / hurt feelings	0.3	0.5	1.0	-0.1	1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	0.0	0.9
Pack years adult smoking proportion	0.3	0.4	0.5	0.6	-0.7
Average weekly fortified wine intake	0.3	0.4	0.6	-0.8	-0.4
Taking other prescription medications	0.3	0.4	0.5	0.7	0.6
Alcohol usually taken with meals	0.3	0.5	0.8	-0.9	-0.5
Medication: Simvastatin	0.3	0.4	0.8	0.9	0.0
Illnesses of siblings	0.3	0.5	0.8	-0.4	-0.9
Number of live births	0.3	0.4	0.6	0.7	-0.5
Length of working week for main job	0.3	0.4	0.7	-0.1	0.9
Breastfed as a baby	0.3	0.4	0.5	-0.6	0.7
Gout (self-reported)	0.3	0.4	0.4	-0.7	0.6
Medication: Allopurinol	0.3	0.4	0.5	-0.7	-0.5
Leg fat mass (right)	0.3	1.2	1.5	0.9	-1.2
Overall health rating	0.3	0.6	1.1	0.4	-1.1
Illnesses of father: Heart disease	0.3	0.4	0.4	-0.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	0.9	-1.0	-0.6
Diabetes diagnosed by doctor	0.3	0.5	1.0	1.0	-0.1
Arm fat mass (left)	0.3	1.3	1.3	1.1	-1.2
Leg fat percentage (left)	0.3	1.2	2.1	1.5	-0.4
Age started oral contraceptive pill	0.3	0.3	0.5	0.4	0.7
Commuting to job workplace: Cycle	0.3	0.4	0.5	0.7	0.5
Alcohol drinker status: Previous	0.3	0.4	0.7	0.8	0.1
Pack years of smoking	0.3	0.5	0.8	0.3	-0.9
Leg fat mass (left)	0.3	1.1	1.8	0.7	-1.3
Bipolar Disorder or Schizophrenia	0.2	0.5	0.8	-0.4	-0.9
Neuroticism (Nagel 2018)	0.2	0.6	1.0	-1.0	-0.3
Schizophrenia (2018)	0.2	0.4	0.8	-0.2	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	0.6	-0.3
Bipolar Disorder (2011)	0.2	0.2	0.4	0.2	-0.7
Fasting Glucose	0.2	0.3	0.5	0.7	0.1
Heel T-Score	0.2	1.9	2.3	-1.5	1.2
Waist Hip Ratio (WHR)	0.2	0.8	1.1	0.7	1.0
Lung FEV1/FVC ratio	0.2	1.2	2.3	1.5	0.4
Chronotype (morning person)	0.2	0.4	0.7	-0.9	-0.4
Tanning	0.2	2.3	4.5	2.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.2	-0.7
Nervous feelings	0.2	0.3	0.5	-0.4	0.7
Mouth/teeth dental problems	0.2	0.3	0.5	-0.1	0.7
Heart attack	0.2	0.2	0.5	0.7	0.0
Diabetes (self-reported)	0.2	0.3	0.6	0.8	-0.0
Hip circumference	0.2	0.7	1.4	0.1	-1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	0.8	-0.9	-0.9
Pulse rate	0.2	0.4	0.5	-0.5	-0.7
Depression (self-reported)	0.2	0.3	0.4	0.7	0.4
Prospective memory result	0.2	0.2	0.4	0.7	-0.0
Illnesses of mother	0.2	0.3	0.3	-0.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.7	0.8	0.1
Hair/balding pattern: Pattern 4	0.2	0.5	0.5	-0.7	-0.7
Loud music exposure frequency	0.2	0.2	0.2	-0.5	0.3
Medication: Paracetamol	0.2	0.3	0.5	-0.3	0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.5	0.5	-0.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.4	0.6	0.4
Medication for pain relief, constipation, heartburn	0.2	0.4	0.6	-0.8	0.5
Leg pain on walking	0.2	0.3	0.3	-0.5	-0.5
Supplements: Vitamin C	0.2	0.2	0.2	-0.5	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	-0.5	-0.4
Back pain experienced in last month	0.2	0.3	0.5	-0.4	0.7
Asthma (self-reported)	0.2	0.3	0.6	0.8	0.0
Average weekly champagne plus white wine intake	0.2	0.3	0.4	-0.5	0.6
Illnesses of father: High blood pressure	0.2	0.3	0.6	0.0	-0.8
Ever smoked	0.2	0.3	0.6	-0.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	0.7	0.2
Heart disease (siblings)	0.2	0.2	0.3	-0.4	0.5
Bipolar Disorder (2018)	0.1	0.1	0.1	-0.4	-0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.6	-0.1
BMI	0.1	0.5	0.7	0.9	-0.5
Systolic Blood Pressure	0.1	0.3	0.5	-0.7	-0.5
Hypothyroidism (self reported)	0.1	0.1	0.2	0.4	-0.4
Hair Pigment	0.1	2.4	3.5	-1.1	1.9
Number of treatments/medications taken	0.1	0.2	0.3	0.6	-0.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.2	-0.4	0.5
Medication: Co-codamol	0.1	0.1	0.1	-0.3	0.1
Diabetes (father)	0.1	0.1	0.2	-0.4	-0.2
Body mass index (BMI)	0.1	0.6	0.7	0.8	-0.7
Waist circumference	0.1	0.3	0.6	0.1	-0.8
Time employed in main current job	0.1	0.1	0.2	0.0	-0.5
Asthma	0.1	0.3	0.4	0.6	0.3
Tense / ‘highly strung’	0.1	0.1	0.3	-0.2	-0.5
Peak expiratory flow (PEF)	0.1	0.3	0.3	-0.6	0.6
Birth weight	0.1	0.2	0.3	0.5	0.3
Number of children fathered	0.1	0.1	0.3	0.5	0.0
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.3	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.1	-0.5
Medication: Ibuprofen	0.1	0.1	0.2	-0.5	-0.2
Age at last live birth	0.1	0.2	0.4	-0.2	-0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	0.0	0.6
Illnesses of siblings: Diabetes	0.1	0.2	0.3	-0.5	-0.2
Average weekly red wine intake	0.1	0.1	0.1	-0.3	0.3
Mood swings	0.1	0.1	0.2	0.3	0.4
Irritability	0.1	0.2	0.3	-0.6	0.3
Fractured/broken bones in last 5 years	0.1	0.1	0.1	-0.3	0.3
Cholesterol lowering medication	0.1	0.1	0.1	-0.4	0.3
Depression (Nagel 2018)	0.0	0.1	0.1	0.0	0.3
Ovarian Cancer	0.0	0.0	0.1	-0.1	0.3
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.3	0.1
Lupus	0.0	0.0	0.1	-0.1	-0.3
Cardiovascular Disease	0.0	0.0	0.0	-0.2	0.0
Respiratory disease	0.0	0.0	0.0	0.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.2	-0.1
Lung FVC	0.0	0.1	0.2	-0.2	0.4
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	-0.2	0.1
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.5	-0.2
Maternal smoking around birth	0.0	0.0	0.0	-0.1	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	-0.2	0.3
Knee pain experienced in last month	0.0	0.0	0.1	0.2	-0.1
Ever had bowel cancer screening	0.0	0.0	0.1	-0.0	-0.2
Mother’s age at death	0.0	0.0	0.1	-0.0	0.3
Medication: Bendroflumethiazide	0.0	0.1	0.1	0.2	-0.4
Medication: Lisinopril	0.0	0.1	0.1	0.1	-0.3
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	0.3	0.2

Hub : Genes

FAM65C

Models

Trait associations