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chr12:111,154,626-113,517,494

Best TWAS P=1.88e-11 · Best GWAS P=1.37e-11 conditioned to 0.00886

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ALDH2	0.05	0.11	blup	223	0.10	1.8e-12	-5.4	5.5	3.0e-08	-0.79	0.94	0.06	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ATXN2	0.02	0.03	enet	8	0.02	4.8e-04	-4.9	6.0	1.7e-09	-0.74	0.10	0.87	FALSE
3	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	-5.2	5.5	4.8e-08	-0.61	0.15	0.59	FALSE
4	GTEx	Adipose Subcutaneous	MAPKAPK5-AS1	0.08	0.01	enet	26	0.03	2.1e-03	-6.2	-5.9	3.3e-09	0.84	0.25	0.75	FALSE
5	GTEx	Adipose Subcutaneous	AC003029.1	0.08	0.07	enet	30	0.05	1.2e-04	-5.1	-6.0	2.1e-09	0.82	0.62	0.38	FALSE
6	GTEx	Adrenal Gland	MAPKAPK5-AS1	0.10	0.08	lasso	12	0.03	3.0e-02	-5.4	-5.4	7.3e-08	0.77	0.39	0.35	FALSE
7	GTEx	Adrenal Gland	AC003029.1	0.12	0.10	lasso	13	0.07	2.0e-03	-5.4	-5.4	6.5e-08	0.77	0.48	0.41	FALSE
8	GTEx	Artery Aorta	ALDH2	0.05	0.04	enet	33	0.05	1.3e-03	-4.2	5.5	4.6e-08	-0.71	0.51	0.22	FALSE
9	GTEx	Artery Aorta	AC003029.1	0.07	0.01	lasso	7	0.01	5.4e-02	-6.5	-6.3	2.6e-10	0.79	0.07	0.73	FALSE
10	GTEx	Artery Coronary	MAPKAPK5-AS1	0.16	0.10	lasso	13	0.06	5.7e-03	-5.1	-5.2	1.7e-07	0.72	0.34	0.17	FALSE
11	GTEx	Artery Tibial	ALDH2	0.08	0.09	lasso	2	0.07	2.7e-06	-5.2	5.4	7.0e-08	-0.76	0.86	0.11	FALSE
12	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	6.0	6.6	4.4e-11	-0.60	0.06	0.68	FALSE
13	GTEx	Breast Mammary Tissue	HECTD4	0.06	0.08	lasso	1	0.07	1.6e-04	-5.1	5.1	3.1e-07	-0.73	0.19	0.52	FALSE
14	GTEx	Cells Transformed fibroblasts	AC003029.1	0.06	0.05	lasso	1	0.03	2.1e-03	-5.1	-5.1	3.1e-07	0.73	0.58	0.14	FALSE
15	GTEx	Colon Transverse	MAPKAPK5-AS1	0.16	0.09	lasso	13	0.06	7.1e-04	-5.1	-5.4	6.8e-08	0.75	0.79	0.05	FALSE
16	GTEx	Colon Transverse	AC003029.1	0.15	0.09	lasso	12	0.07	2.1e-04	-5.1	-5.4	8.4e-08	0.75	0.78	0.05	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	AC003029.1	0.06	0.03	lasso	3	0.04	1.9e-02	-5.4	-5.6	2.1e-08	0.75	0.06	0.62	FALSE
18	GTEx	Esophagus Mucosa	ALDH2	0.05	0.06	lasso	6	0.07	1.7e-05	-5.4	5.8	7.7e-09	-0.81	0.43	0.55	FALSE
19	GTEx	Esophagus Muscularis	HECTD4	0.06	0.03	lasso	4	0.02	1.8e-02	-5.4	6.0	2.3e-09	-0.82	0.12	0.80	FALSE
20	GTEx	Esophagus Muscularis	MAPKAPK5-AS1	0.04	0.02	enet	7	0.02	2.7e-02	-5.5	-5.4	5.6e-08	0.77	0.23	0.36	FALSE
21	GTEx	Lung	ALDH2	0.07	0.01	lasso	10	0.02	5.9e-03	-5.8	5.6	1.6e-08	-0.75	0.25	0.37	FALSE
22	GTEx	Nerve Tibial	ALDH2	0.05	0.04	lasso	3	0.05	2.4e-04	-5.4	5.4	6.1e-08	-0.77	0.58	0.25	FALSE
23	GTEx	Nerve Tibial	HECTD4	0.05	0.01	enet	6	0.01	3.6e-02	-6.1	6.0	1.8e-09	-0.77	0.04	0.90	FALSE
24	GTEx	Pituitary	RP3-462E2.5	0.15	0.12	lasso	3	0.14	2.3e-04	-5.2	5.9	3.4e-09	-0.83	0.14	0.44	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	ALDH2	0.13	0.18	lasso	9	0.16	5.0e-09	-5.1	5.5	3.1e-08	-0.77	0.83	0.17	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	MAPKAPK5-AS1	0.04	0.00	enet	30	0.00	7.0e-01	-5.1	-5.4	7.2e-08	0.76	0.17	0.30	FALSE
27	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	-5.4	6.6	3.3e-11	-0.85	0.56	0.44	FALSE
28	GTEx	Skin Sun Exposed Lower leg	MAPKAPK5-AS1	0.09	0.10	lasso	4	0.10	1.1e-08	-5.1	-5.3	1.4e-07	0.76	0.96	0.04	FALSE
29	GTEx	Skin Sun Exposed Lower leg	AC003029.1	0.09	0.10	lasso	2	0.10	8.8e-09	-5.5	-5.4	6.5e-08	0.76	0.95	0.05	FALSE
30	GTEx	Stomach	TMEM116	0.13	0.03	lasso	7	0.03	1.6e-02	-2.7	-5.3	1.5e-07	0.73	0.05	0.33	FALSE
31	GTEx	Testis	MAPKAPK5	0.23	0.12	lasso	5	0.15	3.1e-07	-4.2	5.3	1.2e-07	-0.65	0.87	0.06	FALSE
32	GTEx	Testis	BRAP	0.06	0.03	enet	13	0.01	8.7e-02	-5.4	-5.7	1.2e-08	0.81	0.25	0.47	FALSE
33	GTEx	Testis	MAPKAPK5-AS1	0.07	0.04	lasso	1	0.03	1.3e-02	-5.1	-5.1	2.8e-07	0.74	0.18	0.19	FALSE
34	GTEx	Thyroid	BRAP	0.07	0.02	lasso	7	0.03	1.1e-03	-6.2	-6.6	3.6e-11	0.86	0.20	0.69	FALSE
35	GTEx	Thyroid	ALDH2	0.06	0.04	lasso	4	0.05	9.7e-05	-6.5	6.0	2.0e-09	-0.81	0.10	0.90	FALSE
36	GTEx	Thyroid	MAPKAPK5-AS1	0.04	0.04	lasso	2	0.03	1.5e-03	-5.1	-5.1	2.9e-07	0.73	0.47	0.26	FALSE
37	GTEx	Thyroid	AC003029.1	0.04	0.05	lasso	3	0.04	8.3e-04	-5.1	-5.3	1.1e-07	0.75	0.42	0.49	FALSE
38	YFS	Blood	SH2B3	0.05	0.01	enet	22	0.02	3.3e-07	-6.2	6.7	1.9e-11	-0.75	0.04	0.96	TRUE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	ALDH2	0.07	0.03	lasso	4	0.06	3.9e-04	-4.1	5.8	6.4e-09	-0.72	0.04	0.78	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACAD10	0.02	0.02	lasso	3	0.01	7.0e-03	-5.6	-5.7	1.4e-08	0.74	0.02	0.74	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALDH2	0.03	0.03	lasso	1	0.03	3.1e-04	-5.4	5.4	8.6e-08	-0.75	0.02	0.66	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAPKAPK5	0.03	0.01	blup	42	0.01	2.5e-02	-4.2	5.3	9.6e-08	-0.72	0.05	0.44	FALSE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP29	0.11	0.03	blup	25	0.05	5.0e-03	-5.4	-6.2	7.2e-10	0.74	0.02	0.61	FALSE