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chr11:12,611,333-18,106,069

Best TWAS P=3.79e-26 · Best GWAS P=4.01e-29 conditioned to 4.74e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DKFZp686O24166	0.03	0.01	blup	72	0.03	2.4e-04	10.2	-10.6	3.8e-26	-0.05	0.01	0.96	TRUE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SOX6	0.12	-0.01	blup	250	0.02	3.1e-02	2.7	-7.4	1.4e-13	-0.46	0.05	0.12	TRUE
17	GTEx	Cells Transformed fibroblasts	COPB1	0.07	0.02	lasso	13	0.02	7.9e-03	-4.7	6.0	2.1e-09	-0.05	0.15	0.82	TRUE
62	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SOX6	0.21	0.05	lasso	5	0.09	3.5e-05	8.0	-5.9	3.2e-09	-0.35	0.59	0.03	TRUE
46	GTEx	Whole Blood	ARNTL	0.12	0.10	enet	26	0.10	2.5e-09	-5.5	-5.3	9.5e-08	0.02	0.15	0.85	TRUE
2	CommonMind	Brain Pre-frontal Cortex	KCNJ11	0.04	0.03	lasso	3	0.03	2.6e-04	9.8	10.2	3.3e-24	0.07	0.01	0.98	FALSE
35	GTEx	Skin Sun Exposed Lower leg	KCNJ11	0.23	0.09	lasso	10	0.12	1.7e-10	10.1	-10.1	3.4e-24	-0.04	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DKFZp686O24166	0.04	0.00	blup	71	0.02	7.1e-03	-7.5	-10.1	8.6e-24	-0.04	0.01	0.82	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DKFZp686O24166	0.05	0.03	blup	71	0.04	1.2e-05	-7.5	-9.9	2.6e-23	-0.06	0.01	0.98	FALSE
45	GTEx	Thyroid	RP1-239B22.5	0.08	0.07	enet	16	0.08	1.8e-06	10.1	-9.9	6.1e-23	-0.07	0.00	0.99	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	KCNJ11	0.18	0.07	lasso	6	0.12	7.0e-07	9.8	-9.8	1.2e-22	-0.06	0.01	0.99	FALSE
37	GTEx	Skin Sun Exposed Lower leg	RP1-239B22.5	0.06	0.06	lasso	2	0.07	8.6e-07	-7.6	-9.7	3.1e-22	-0.05	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NUCB2	0.10	0.04	enet	8	0.05	2.6e-06	-6.6	-9.2	4.0e-20	-0.05	0.66	0.14	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DKFZp686O24166	0.08	0.07	lasso	4	0.05	1.2e-03	-7.5	-9.2	4.2e-20	-0.05	0.03	0.92	FALSE
22	GTEx	Esophagus Mucosa	KCNJ11	0.27	0.16	lasso	8	0.22	1.6e-14	-6.7	-9.1	1.1e-19	-0.05	0.26	0.74	FALSE
24	GTEx	Esophagus Mucosa	RP1-239B22.5	0.28	0.28	enet	47	0.32	2.9e-22	-6.7	-8.8	9.1e-19	-0.07	0.96	0.04	FALSE
31	GTEx	Nerve Tibial	RP1-239B22.5	0.11	0.08	lasso	2	0.08	2.9e-06	-5.7	-8.8	2.2e-18	-0.01	0.02	0.95	FALSE
23	GTEx	Esophagus Mucosa	NCR3LG1	0.38	0.38	enet	39	0.42	3.7e-30	-6.7	-8.7	4.6e-18	-0.05	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUCB2	0.17	0.06	blup	66	0.06	2.8e-07	7.9	8.4	4.4e-17	0.05	0.75	0.25	FALSE
61	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PIK3C2A	0.05	0.01	blup	52	0.03	7.2e-03	8.1	-8.4	5.7e-17	-0.07	0.02	0.64	FALSE
5	GTEx	Adipose Subcutaneous	RP1-239B22.5	0.11	0.06	enet	21	0.07	1.5e-06	9.8	-7.8	5.9e-15	-0.07	0.01	0.99	FALSE
13	GTEx	Breast Mammary Tissue (Female)	OR7E14P	0.19	0.07	lasso	6	0.07	3.4e-03	6.3	-7.8	6.7e-15	-0.08	0.17	0.08	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	PIK3C2A	0.08	0.05	lasso	3	0.05	9.6e-06	8.1	-7.8	7.3e-15	-0.03	0.00	0.99	FALSE
4	GTEx	Adipose Subcutaneous	OR7E14P	0.10	0.09	lasso	5	0.10	1.2e-08	-6.3	-7.8	8.5e-15	-0.08	0.99	0.01	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	DKFZp686O24166	0.04	0.01	blup	71	0.02	1.5e-03	8.7	-7.7	1.6e-14	-0.08	0.01	0.88	FALSE
9	GTEx	Artery Tibial	KCNJ11	0.18	0.19	lasso	6	0.19	1.6e-14	-7.1	-7.6	2.8e-14	-0.01	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DKFZp686O24166	0.08	0.04	blup	72	0.01	1.4e-01	-7.5	-7.5	9.3e-14	-0.04	0.03	0.09	FALSE
12	GTEx	Brain Cortex	KCNJ11	0.17	0.01	enet	24	0.06	7.7e-03	-6.9	7.4	1.3e-13	0.04	0.08	0.56	FALSE
18	GTEx	Colon Transverse	NUCB2	0.13	0.09	lasso	6	0.06	9.6e-04	-6.3	-7.4	1.5e-13	-0.08	0.83	0.04	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	KCNJ11	0.05	0.06	enet	6	0.05	3.0e-07	7.9	7.3	2.0e-13	0.09	0.18	0.81	FALSE
39	GTEx	Stomach	OR7E14P	0.23	0.07	enet	25	0.01	7.5e-02	-6.3	-7.3	2.4e-13	-0.07	0.65	0.08	FALSE
43	GTEx	Thyroid	NUCB2	0.07	0.02	lasso	4	0.02	1.3e-02	-6.9	-7.3	2.6e-13	-0.06	0.21	0.05	FALSE
36	GTEx	Skin Sun Exposed Lower leg	NCR3LG1	0.12	0.12	lasso	5	0.13	5.0e-11	-7.6	-7.3	3.0e-13	-0.02	0.98	0.02	FALSE
16	GTEx	Cells Transformed fibroblasts	NUCB2	0.13	0.11	lasso	2	0.09	1.7e-07	-7.2	-7.3	3.2e-13	-0.08	0.98	0.01	FALSE
48	METSIM	Adipose	NUCB2	0.05	0.07	enet	10	0.05	4.0e-08	-7.2	-7.2	4.6e-13	-0.09	0.77	0.23	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	NUCB2	0.36	0.23	lasso	6	0.24	2.6e-08	-7.1	-7.2	5.2e-13	-0.07	0.94	0.02	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	NUCB2	0.23	0.32	lasso	5	0.31	8.1e-41	-7.0	7.2	5.5e-13	0.04	1.00	0.00	FALSE
11	GTEx	Brain Cortex	NUCB2	0.21	0.12	lasso	4	0.10	1.1e-03	-6.7	7.2	6.2e-13	0.03	0.32	0.16	FALSE
38	GTEx	Spleen	NUCB2	0.20	0.21	lasso	2	0.17	4.2e-05	-7.1	-7.2	6.7e-13	-0.07	0.23	0.24	FALSE
20	GTEx	Esophagus Mucosa	NUCB2	0.08	0.03	lasso	4	0.04	8.8e-04	6.3	-7.0	2.4e-12	-0.08	0.67	0.05	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	OR7E14P	0.04	0.04	lasso	4	0.04	9.1e-06	-6.3	-7.0	3.4e-12	-0.07	0.89	0.07	FALSE
40	GTEx	Testis	NUCB2	0.28	0.13	lasso	9	0.10	2.5e-05	-7.2	7.0	3.5e-12	0.07	0.61	0.02	FALSE
15	GTEx	Cells Transformed fibroblasts	PIK3C2A	0.10	0.08	lasso	4	0.08	1.3e-06	6.0	-6.8	1.1e-11	-0.08	0.84	0.04	FALSE
25	GTEx	Esophagus Muscularis	RP1-239B22.5	0.06	0.08	enet	8	0.08	1.3e-05	-6.3	-6.7	2.3e-11	-0.08	0.69	0.10	FALSE
34	GTEx	Skin Sun Exposed Lower leg	SOX6	0.08	0.00	lasso	7	0.00	3.1e-01	-3.3	-6.4	1.5e-10	-0.36	0.04	0.64	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	KCNJ11	0.20	0.15	lasso	7	0.18	4.0e-07	-7.6	-6.3	2.2e-10	0.03	0.58	0.05	FALSE
30	GTEx	Nerve Tibial	OR7E14P	0.18	0.28	lasso	3	0.28	9.5e-20	6.3	-6.3	2.5e-10	-0.08	1.00	0.00	FALSE
26	GTEx	Heart Atrial Appendage	OR7E14P	0.14	0.02	lasso	1	0.03	1.7e-02	-6.3	-6.3	3.5e-10	-0.08	0.12	0.27	FALSE
29	GTEx	Muscle Skeletal	OR7E14P	0.05	0.04	enet	13	0.03	7.5e-04	-6.3	-6.2	4.3e-10	-0.09	0.92	0.01	FALSE
42	GTEx	Testis	OR7E14P	0.38	0.33	lasso	6	0.32	7.1e-15	6.3	-6.2	5.5e-10	-0.07	1.00	0.00	FALSE
21	GTEx	Esophagus Mucosa	OR7E14P	0.33	0.32	enet	31	0.41	1.6e-29	-6.9	-6.1	8.4e-10	-0.08	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Skin Cutaneous Melanoma	PIK3C2A	0.10	0.09	lasso	7	0.09	2.7e-03	-6.3	-6.0	1.5e-09	-0.08	0.05	0.15	FALSE
28	GTEx	Liver	SOX6	0.51	0.39	enet	31	0.36	6.1e-11	8.0	-5.8	8.7e-09	-0.53	0.83	0.15	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	DKFZp686O24166	0.05	0.01	blup	72	0.02	5.1e-03	-1.7	-5.7	9.3e-09	-0.11	0.01	0.85	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	KCNJ11	0.04	0.01	enet	9	0.02	4.9e-03	-6.1	5.7	9.4e-09	-0.01	0.03	0.05	FALSE
32	GTEx	Ovary	NUCB2	0.31	-0.01	enet	35	0.01	2.0e-01	-6.3	-5.7	1.1e-08	-0.01	0.09	0.24	FALSE
50	NTR	Blood	SPON1	0.05	0.02	blup	507	0.04	2.4e-13	-4.8	5.7	1.4e-08	0.01	0.64	0.36	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CYP2R1	0.06	0.05	lasso	5	0.04	9.3e-06	5.5	-5.6	2.4e-08	-0.02	0.05	0.95	FALSE
47	METSIM	Adipose	COPB1	0.06	0.01	bslmm	362	0.02	2.9e-04	4.2	5.6	2.5e-08	-0.01	0.06	0.52	FALSE
8	GTEx	Artery Tibial	OR7E14P	0.10	0.07	lasso	8	0.04	3.4e-04	-5.9	-5.5	2.8e-08	-0.08	0.86	0.02	FALSE
41	GTEx	Testis	RRAS2	0.18	0.13	enet	19	0.15	2.7e-07	4.6	-5.4	7.3e-08	0.01	0.56	0.43	FALSE
3	GTEx	Adipose Subcutaneous	RRAS2	0.11	0.02	lasso	3	0.02	9.0e-03	4.6	-5.4	7.5e-08	0.07	0.35	0.35	FALSE
7	GTEx	Artery Tibial	RRAS2	0.08	0.06	lasso	5	0.07	5.7e-06	4.7	-5.4	8.0e-08	-0.01	0.55	0.42	FALSE
6	GTEx	Artery Coronary	OR7E14P	0.19	0.01	enet	26	0.00	3.4e-01	7.5	-5.4	8.2e-08	-0.07	0.13	0.04	FALSE
54	YFS	Blood	NUCB2	0.12	0.13	lasso	4	0.14	2.7e-44	-6.9	-5.3	9.8e-08	-0.06	1.00	0.00	FALSE
10	GTEx	Brain Cerebellum	COPB1	0.16	0.09	lasso	8	0.06	9.3e-03	-5.0	5.3	1.2e-07	-0.02	0.05	0.80	FALSE
44	GTEx	Thyroid	RRAS2	0.09	0.02	enet	8	0.07	7.6e-06	3.7	-5.3	1.2e-07	0.01	0.39	0.35	FALSE
27	GTEx	Heart Left Ventricle	OR7E14P	0.08	0.06	enet	18	0.07	1.2e-04	-5.9	-5.2	1.8e-07	-0.04	0.25	0.19	FALSE
49	NTR	Blood	COPB1	0.02	0.01	enet	6	0.01	1.1e-05	-3.7	5.1	2.7e-07	-0.06	0.64	0.29	FALSE