[Hub]/) : Traits : Systolic Blood Pressure :

chr11:56,253,681-58,178,587

Best TWAS P=8.39e-21 · Best GWAS P=1.06e-15 conditioned to 4.14e-13

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LRRC55 0.05 0.02 blup 439 0.03 5.1e-05 0.67 -5.8 4.8e-09 0.33 0.44 0.25 TRUE
2 GTEx Adipose Subcutaneous MED19 0.23 0.06 enet 29 0.18 2.0e-14 6.22 8.6 8.1e-18 -0.05 0.06 0.94 FALSE
3 GTEx Artery Coronary MED19 0.13 0.07 enet 21 0.07 2.7e-03 6.30 6.6 3.6e-11 0.13 0.27 0.08 FALSE
4 GTEx Artery Tibial MED19 0.22 0.12 enet 37 0.16 6.6e-13 6.22 7.4 9.9e-14 0.08 1.00 0.00 FALSE
5 GTEx Breast Mammary Tissue MED19 0.11 0.04 enet 26 0.10 7.5e-06 -7.74 7.8 9.1e-15 0.07 0.01 0.94 FALSE
6 GTEx Cells Transformed fibroblasts MED19 0.10 0.09 lasso 3 0.09 4.7e-07 6.30 6.2 4.7e-10 0.13 0.98 0.00 FALSE
7 GTEx Colon Transverse MED19 0.10 0.00 enet 28 0.08 1.4e-04 6.22 7.1 9.7e-13 0.14 0.04 0.85 FALSE
8 GTEx Esophagus Mucosa MED19 0.14 0.07 lasso 4 0.11 5.9e-08 -5.11 7.3 3.2e-13 -0.01 0.02 0.98 FALSE
9 GTEx Esophagus Muscularis MED19 0.20 0.15 lasso 4 0.12 5.7e-08 6.30 6.3 2.2e-10 0.09 0.98 0.01 FALSE
10 GTEx Heart Atrial Appendage MED19 0.11 0.14 lasso 1 0.14 6.0e-07 -7.74 7.7 1.0e-14 -0.06 0.02 0.98 FALSE
11 GTEx Lung MED19 0.12 0.00 enet 12 0.06 2.9e-05 6.22 9.3 8.4e-21 0.08 0.12 0.81 TRUE
12 GTEx Muscle Skeletal MED19 0.06 0.06 lasso 7 0.06 1.9e-06 6.22 7.3 2.5e-13 0.09 0.91 0.05 FALSE
13 GTEx Nerve Tibial MED19 0.12 0.00 enet 25 0.02 2.1e-02 6.19 8.2 2.3e-16 0.08 0.31 0.57 FALSE
14 GTEx Pancreas MED19 0.10 0.08 lasso 3 0.02 5.0e-02 -7.82 7.8 5.3e-15 -0.05 0.01 0.90 FALSE
15 GTEx Skin Not Sun Exposed Suprapubic MED19 0.12 0.05 enet 31 0.05 7.5e-04 -7.91 8.7 4.6e-18 -0.07 0.01 0.98 FALSE
16 GTEx Skin Sun Exposed Lower leg ZDHHC5 0.05 0.03 lasso 8 0.02 6.2e-03 -7.88 -6.7 1.7e-11 0.09 0.04 0.95 FALSE
17 GTEx Skin Sun Exposed Lower leg MED19 0.15 0.11 lasso 7 0.09 1.3e-07 -8.00 8.5 2.3e-17 -0.04 0.01 0.99 FALSE
18 GTEx Spleen MED19 0.20 0.17 lasso 8 0.08 5.4e-03 6.19 6.4 1.2e-10 0.09 0.24 0.18 FALSE
19 GTEx Stomach MED19 0.10 0.04 lasso 7 0.09 6.8e-05 -7.88 8.6 9.8e-18 -0.01 0.02 0.91 FALSE
20 GTEx Thyroid MED19 0.11 0.02 lasso 12 0.07 3.2e-06 -5.14 8.6 6.0e-18 0.10 0.18 0.80 FALSE
21 GTEx Uterus MED19 0.33 0.11 lasso 17 0.08 8.8e-03 6.22 5.7 1.3e-08 0.09 0.22 0.07 FALSE
22 GTEx Vagina MED19 0.26 0.03 lasso 10 0.06 1.5e-02 -0.12 5.1 3.0e-07 0.01 0.03 0.74 FALSE
23 GTEx Whole Blood MED19 0.05 0.01 lasso 8 0.01 5.2e-02 5.58 6.5 6.1e-11 0.13 0.24 0.19 FALSE
24 METSIM Adipose MED19 0.11 0.08 lasso 5 0.07 4.5e-11 5.95 7.2 6.7e-13 0.06 0.99 0.01 FALSE
25 NTR Blood MED19 0.04 0.04 enet 18 0.04 2.4e-13 6.30 6.8 8.7e-12 0.11 1.00 0.00 FALSE
26 ROSMAP Brain Pre-frontal Cortex ZDHHC5 0.05 0.02 blup 401 0.03 2.0e-04 -7.70 6.6 3.7e-11 -0.03 0.02 0.95 FALSE
27 ROSMAP Brain Pre-frontal Cortex AP000662.4 0.05 0.01 enet 17 0.02 3.8e-04 -5.15 5.2 2.1e-07 -0.01 0.12 0.86 FALSE
28 YFS Blood MED19 0.47 0.18 enet 73 0.28 7.1e-93 6.30 8.0 1.7e-15 0.00 1.00 0.00 FALSE
29 YFS Blood SERPING1 0.04 0.04 lasso 6 0.04 1.2e-12 -6.71 -5.6 2.1e-08 0.05 0.98 0.02 FALSE
30 YFS Blood ZDHHC5 0.06 0.07 enet 20 0.07 1.2e-22 -7.74 -7.2 5.6e-13 0.05 0.01 0.99 FALSE
31 The Cancer Genome Atlas Bladder Urothelial Carcinoma MED19 0.07 0.01 blup 26 0.05 7.4e-05 6.19 7.8 6.4e-15 0.04 0.04 0.86 FALSE
32 The Cancer Genome Atlas Breast Invasive Carcinoma MED19 0.05 0.03 enet 7 0.05 1.3e-10 -7.88 8.5 1.9e-17 0.01 0.01 0.99 FALSE
33 The Cancer Genome Atlas Colon Adenocarcinoma TMX2 0.07 0.06 lasso 1 0.05 5.0e-04 -8.00 -8.0 1.2e-15 0.05 0.00 0.92 FALSE
34 The Cancer Genome Atlas Colon Adenocarcinoma ZDHHC5 0.10 0.05 blup 34 0.04 1.8e-03 6.19 5.8 6.3e-09 0.09 0.11 0.09 FALSE
35 The Cancer Genome Atlas Esophageal Carcinoma MED19 0.10 0.06 lasso 4 0.02 5.4e-02 -7.97 8.0 1.6e-15 -0.05 0.00 0.86 FALSE
36 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MED19 0.03 0.01 lasso 2 0.02 1.9e-03 -7.88 8.0 1.5e-15 0.00 0.01 0.66 FALSE
37 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MED19 0.15 0.05 enet 11 0.08 1.4e-09 6.29 5.3 1.2e-07 0.07 0.88 0.11 FALSE
38 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MED19 0.09 0.05 lasso 2 0.07 9.2e-05 6.19 8.1 8.3e-16 0.03 0.03 0.82 FALSE
39 The Cancer Genome Atlas Lung Adenocarcinoma MED19 0.05 0.02 blup 26 0.03 6.0e-05 -8.00 8.3 9.3e-17 0.01 0.00 0.99 FALSE
40 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MED19 0.03 0.02 lasso 1 0.01 1.8e-02 -7.74 7.7 1.0e-14 -0.06 0.01 0.84 FALSE
41 The Cancer Genome Atlas Pancreatic Adenocarcinoma MED19 0.13 0.06 blup 26 0.13 4.7e-06 6.19 8.1 3.9e-16 0.03 0.05 0.82 FALSE
42 The Cancer Genome Atlas Prostate Adenocarcinoma MED19 0.07 0.05 blup 26 0.05 4.4e-06 6.19 7.9 2.1e-15 0.04 0.47 0.46 FALSE
43 The Cancer Genome Atlas Prostate Adenocarcinoma YPEL4 0.04 0.03 lasso 3 0.03 8.0e-04 5.58 6.8 9.6e-12 0.06 0.02 0.56 FALSE
44 The Cancer Genome Atlas Prostate Adenocarcinoma ZDHHC5 0.10 0.11 lasso 3 0.11 2.9e-11 6.19 6.2 5.1e-10 0.08 1.00 0.00 FALSE
45 The Cancer Genome Atlas Soft Tissue Sarcoma MED19 0.09 0.08 lasso 1 0.08 1.2e-05 6.19 6.2 5.9e-10 0.08 0.44 0.18 FALSE
46 The Cancer Genome Atlas Testicular Germ Cell Tumors MED19 0.10 0.04 blup 26 0.03 3.6e-02 6.19 8.0 1.0e-15 0.04 0.02 0.39 FALSE
47 The Cancer Genome Atlas Thyroid Carcinoma MED19 0.10 0.05 blup 26 0.09 3.8e-09 6.19 8.0 9.1e-16 0.03 0.07 0.93 FALSE
48 The Cancer Genome Atlas Thyroid Carcinoma SERPING1 0.06 0.03 blup 52 0.04 6.3e-05 -6.59 5.7 1.1e-08 -0.03 0.26 0.47 FALSE