[Hub]/) : Traits : Systolic Blood Pressure : ← →

chr11:56,253,681-58,178,587

Best TWAS P=8.39e-21 · Best GWAS P=1.06e-15 conditioned to 4.14e-13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LRRC55	0.05	0.02	blup	439	0.03	5.1e-05	0.67	-5.8	4.8e-09	0.33	0.44	0.25	TRUE
2	GTEx	Adipose Subcutaneous	MED19	0.23	0.06	enet	29	0.18	2.0e-14	6.22	8.6	8.1e-18	-0.05	0.06	0.94	FALSE
3	GTEx	Artery Coronary	MED19	0.13	0.07	enet	21	0.07	2.7e-03	6.30	6.6	3.6e-11	0.13	0.27	0.08	FALSE
4	GTEx	Artery Tibial	MED19	0.22	0.12	enet	37	0.16	6.6e-13	6.22	7.4	9.9e-14	0.08	1.00	0.00	FALSE
5	GTEx	Breast Mammary Tissue	MED19	0.11	0.04	enet	26	0.10	7.5e-06	-7.74	7.8	9.1e-15	0.07	0.01	0.94	FALSE
6	GTEx	Cells Transformed fibroblasts	MED19	0.10	0.09	lasso	3	0.09	4.7e-07	6.30	6.2	4.7e-10	0.13	0.98	0.00	FALSE
7	GTEx	Colon Transverse	MED19	0.10	0.00	enet	28	0.08	1.4e-04	6.22	7.1	9.7e-13	0.14	0.04	0.85	FALSE
8	GTEx	Esophagus Mucosa	MED19	0.14	0.07	lasso	4	0.11	5.9e-08	-5.11	7.3	3.2e-13	-0.01	0.02	0.98	FALSE
9	GTEx	Esophagus Muscularis	MED19	0.20	0.15	lasso	4	0.12	5.7e-08	6.30	6.3	2.2e-10	0.09	0.98	0.01	FALSE
10	GTEx	Heart Atrial Appendage	MED19	0.11	0.14	lasso	1	0.14	6.0e-07	-7.74	7.7	1.0e-14	-0.06	0.02	0.98	FALSE
11	GTEx	Lung	MED19	0.12	0.00	enet	12	0.06	2.9e-05	6.22	9.3	8.4e-21	0.08	0.12	0.81	TRUE
12	GTEx	Muscle Skeletal	MED19	0.06	0.06	lasso	7	0.06	1.9e-06	6.22	7.3	2.5e-13	0.09	0.91	0.05	FALSE
13	GTEx	Nerve Tibial	MED19	0.12	0.00	enet	25	0.02	2.1e-02	6.19	8.2	2.3e-16	0.08	0.31	0.57	FALSE
14	GTEx	Pancreas	MED19	0.10	0.08	lasso	3	0.02	5.0e-02	-7.82	7.8	5.3e-15	-0.05	0.01	0.90	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	MED19	0.12	0.05	enet	31	0.05	7.5e-04	-7.91	8.7	4.6e-18	-0.07	0.01	0.98	FALSE
16	GTEx	Skin Sun Exposed Lower leg	ZDHHC5	0.05	0.03	lasso	8	0.02	6.2e-03	-7.88	-6.7	1.7e-11	0.09	0.04	0.95	FALSE
17	GTEx	Skin Sun Exposed Lower leg	MED19	0.15	0.11	lasso	7	0.09	1.3e-07	-8.00	8.5	2.3e-17	-0.04	0.01	0.99	FALSE
18	GTEx	Spleen	MED19	0.20	0.17	lasso	8	0.08	5.4e-03	6.19	6.4	1.2e-10	0.09	0.24	0.18	FALSE
19	GTEx	Stomach	MED19	0.10	0.04	lasso	7	0.09	6.8e-05	-7.88	8.6	9.8e-18	-0.01	0.02	0.91	FALSE
20	GTEx	Thyroid	MED19	0.11	0.02	lasso	12	0.07	3.2e-06	-5.14	8.6	6.0e-18	0.10	0.18	0.80	FALSE
21	GTEx	Uterus	MED19	0.33	0.11	lasso	17	0.08	8.8e-03	6.22	5.7	1.3e-08	0.09	0.22	0.07	FALSE
22	GTEx	Vagina	MED19	0.26	0.03	lasso	10	0.06	1.5e-02	-0.12	5.1	3.0e-07	0.01	0.03	0.74	FALSE
23	GTEx	Whole Blood	MED19	0.05	0.01	lasso	8	0.01	5.2e-02	5.58	6.5	6.1e-11	0.13	0.24	0.19	FALSE
24	METSIM	Adipose	MED19	0.11	0.08	lasso	5	0.07	4.5e-11	5.95	7.2	6.7e-13	0.06	0.99	0.01	FALSE
25	NTR	Blood	MED19	0.04	0.04	enet	18	0.04	2.4e-13	6.30	6.8	8.7e-12	0.11	1.00	0.00	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	ZDHHC5	0.05	0.02	blup	401	0.03	2.0e-04	-7.70	6.6	3.7e-11	-0.03	0.02	0.95	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	AP000662.4	0.05	0.01	enet	17	0.02	3.8e-04	-5.15	5.2	2.1e-07	-0.01	0.12	0.86	FALSE
28	YFS	Blood	MED19	0.47	0.18	enet	73	0.28	7.1e-93	6.30	8.0	1.7e-15	0.00	1.00	0.00	FALSE
29	YFS	Blood	SERPING1	0.04	0.04	lasso	6	0.04	1.2e-12	-6.71	-5.6	2.1e-08	0.05	0.98	0.02	FALSE
30	YFS	Blood	ZDHHC5	0.06	0.07	enet	20	0.07	1.2e-22	-7.74	-7.2	5.6e-13	0.05	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MED19	0.07	0.01	blup	26	0.05	7.4e-05	6.19	7.8	6.4e-15	0.04	0.04	0.86	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	MED19	0.05	0.03	enet	7	0.05	1.3e-10	-7.88	8.5	1.9e-17	0.01	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	TMX2	0.07	0.06	lasso	1	0.05	5.0e-04	-8.00	-8.0	1.2e-15	0.05	0.00	0.92	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	ZDHHC5	0.10	0.05	blup	34	0.04	1.8e-03	6.19	5.8	6.3e-09	0.09	0.11	0.09	FALSE
35	The Cancer Genome Atlas	Esophageal Carcinoma	MED19	0.10	0.06	lasso	4	0.02	5.4e-02	-7.97	8.0	1.6e-15	-0.05	0.00	0.86	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MED19	0.03	0.01	lasso	2	0.02	1.9e-03	-7.88	8.0	1.5e-15	0.00	0.01	0.66	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MED19	0.15	0.05	enet	11	0.08	1.4e-09	6.29	5.3	1.2e-07	0.07	0.88	0.11	FALSE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MED19	0.09	0.05	lasso	2	0.07	9.2e-05	6.19	8.1	8.3e-16	0.03	0.03	0.82	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	MED19	0.05	0.02	blup	26	0.03	6.0e-05	-8.00	8.3	9.3e-17	0.01	0.00	0.99	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MED19	0.03	0.02	lasso	1	0.01	1.8e-02	-7.74	7.7	1.0e-14	-0.06	0.01	0.84	FALSE
41	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MED19	0.13	0.06	blup	26	0.13	4.7e-06	6.19	8.1	3.9e-16	0.03	0.05	0.82	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	MED19	0.07	0.05	blup	26	0.05	4.4e-06	6.19	7.9	2.1e-15	0.04	0.47	0.46	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	YPEL4	0.04	0.03	lasso	3	0.03	8.0e-04	5.58	6.8	9.6e-12	0.06	0.02	0.56	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZDHHC5	0.10	0.11	lasso	3	0.11	2.9e-11	6.19	6.2	5.1e-10	0.08	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Soft Tissue Sarcoma	MED19	0.09	0.08	lasso	1	0.08	1.2e-05	6.19	6.2	5.9e-10	0.08	0.44	0.18	FALSE
46	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MED19	0.10	0.04	blup	26	0.03	3.6e-02	6.19	8.0	1.0e-15	0.04	0.02	0.39	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	MED19	0.10	0.05	blup	26	0.09	3.8e-09	6.19	8.0	9.1e-16	0.03	0.07	0.93	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	SERPING1	0.06	0.03	blup	52	0.04	6.3e-05	-6.59	5.7	1.1e-08	-0.03	0.26	0.47	FALSE