Best TWAS P=8.39e-21 · Best GWAS P=1.06e-15 conditioned to 4.14e-13
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | LRRC55 | 0.05 | 0.02 | blup | 439 | 0.03 | 5.1e-05 | 0.67 | -5.8 | 4.8e-09 | 0.33 | 0.44 | 0.25 | TRUE |
2 | GTEx | Adipose Subcutaneous | MED19 | 0.23 | 0.06 | enet | 29 | 0.18 | 2.0e-14 | 6.22 | 8.6 | 8.1e-18 | -0.05 | 0.06 | 0.94 | FALSE |
3 | GTEx | Artery Coronary | MED19 | 0.13 | 0.07 | enet | 21 | 0.07 | 2.7e-03 | 6.30 | 6.6 | 3.6e-11 | 0.13 | 0.27 | 0.08 | FALSE |
4 | GTEx | Artery Tibial | MED19 | 0.22 | 0.12 | enet | 37 | 0.16 | 6.6e-13 | 6.22 | 7.4 | 9.9e-14 | 0.08 | 1.00 | 0.00 | FALSE |
5 | GTEx | Breast Mammary Tissue | MED19 | 0.11 | 0.04 | enet | 26 | 0.10 | 7.5e-06 | -7.74 | 7.8 | 9.1e-15 | 0.07 | 0.01 | 0.94 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | MED19 | 0.10 | 0.09 | lasso | 3 | 0.09 | 4.7e-07 | 6.30 | 6.2 | 4.7e-10 | 0.13 | 0.98 | 0.00 | FALSE |
7 | GTEx | Colon Transverse | MED19 | 0.10 | 0.00 | enet | 28 | 0.08 | 1.4e-04 | 6.22 | 7.1 | 9.7e-13 | 0.14 | 0.04 | 0.85 | FALSE |
8 | GTEx | Esophagus Mucosa | MED19 | 0.14 | 0.07 | lasso | 4 | 0.11 | 5.9e-08 | -5.11 | 7.3 | 3.2e-13 | -0.01 | 0.02 | 0.98 | FALSE |
9 | GTEx | Esophagus Muscularis | MED19 | 0.20 | 0.15 | lasso | 4 | 0.12 | 5.7e-08 | 6.30 | 6.3 | 2.2e-10 | 0.09 | 0.98 | 0.01 | FALSE |
10 | GTEx | Heart Atrial Appendage | MED19 | 0.11 | 0.14 | lasso | 1 | 0.14 | 6.0e-07 | -7.74 | 7.7 | 1.0e-14 | -0.06 | 0.02 | 0.98 | FALSE |
11 | GTEx | Lung | MED19 | 0.12 | 0.00 | enet | 12 | 0.06 | 2.9e-05 | 6.22 | 9.3 | 8.4e-21 | 0.08 | 0.12 | 0.81 | TRUE |
12 | GTEx | Muscle Skeletal | MED19 | 0.06 | 0.06 | lasso | 7 | 0.06 | 1.9e-06 | 6.22 | 7.3 | 2.5e-13 | 0.09 | 0.91 | 0.05 | FALSE |
13 | GTEx | Nerve Tibial | MED19 | 0.12 | 0.00 | enet | 25 | 0.02 | 2.1e-02 | 6.19 | 8.2 | 2.3e-16 | 0.08 | 0.31 | 0.57 | FALSE |
14 | GTEx | Pancreas | MED19 | 0.10 | 0.08 | lasso | 3 | 0.02 | 5.0e-02 | -7.82 | 7.8 | 5.3e-15 | -0.05 | 0.01 | 0.90 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | MED19 | 0.12 | 0.05 | enet | 31 | 0.05 | 7.5e-04 | -7.91 | 8.7 | 4.6e-18 | -0.07 | 0.01 | 0.98 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | ZDHHC5 | 0.05 | 0.03 | lasso | 8 | 0.02 | 6.2e-03 | -7.88 | -6.7 | 1.7e-11 | 0.09 | 0.04 | 0.95 | FALSE |
17 | GTEx | Skin Sun Exposed Lower leg | MED19 | 0.15 | 0.11 | lasso | 7 | 0.09 | 1.3e-07 | -8.00 | 8.5 | 2.3e-17 | -0.04 | 0.01 | 0.99 | FALSE |
18 | GTEx | Spleen | MED19 | 0.20 | 0.17 | lasso | 8 | 0.08 | 5.4e-03 | 6.19 | 6.4 | 1.2e-10 | 0.09 | 0.24 | 0.18 | FALSE |
19 | GTEx | Stomach | MED19 | 0.10 | 0.04 | lasso | 7 | 0.09 | 6.8e-05 | -7.88 | 8.6 | 9.8e-18 | -0.01 | 0.02 | 0.91 | FALSE |
20 | GTEx | Thyroid | MED19 | 0.11 | 0.02 | lasso | 12 | 0.07 | 3.2e-06 | -5.14 | 8.6 | 6.0e-18 | 0.10 | 0.18 | 0.80 | FALSE |
21 | GTEx | Uterus | MED19 | 0.33 | 0.11 | lasso | 17 | 0.08 | 8.8e-03 | 6.22 | 5.7 | 1.3e-08 | 0.09 | 0.22 | 0.07 | FALSE |
22 | GTEx | Vagina | MED19 | 0.26 | 0.03 | lasso | 10 | 0.06 | 1.5e-02 | -0.12 | 5.1 | 3.0e-07 | 0.01 | 0.03 | 0.74 | FALSE |
23 | GTEx | Whole Blood | MED19 | 0.05 | 0.01 | lasso | 8 | 0.01 | 5.2e-02 | 5.58 | 6.5 | 6.1e-11 | 0.13 | 0.24 | 0.19 | FALSE |
24 | METSIM | Adipose | MED19 | 0.11 | 0.08 | lasso | 5 | 0.07 | 4.5e-11 | 5.95 | 7.2 | 6.7e-13 | 0.06 | 0.99 | 0.01 | FALSE |
25 | NTR | Blood | MED19 | 0.04 | 0.04 | enet | 18 | 0.04 | 2.4e-13 | 6.30 | 6.8 | 8.7e-12 | 0.11 | 1.00 | 0.00 | FALSE |
26 | ROSMAP | Brain Pre-frontal Cortex | ZDHHC5 | 0.05 | 0.02 | blup | 401 | 0.03 | 2.0e-04 | -7.70 | 6.6 | 3.7e-11 | -0.03 | 0.02 | 0.95 | FALSE |
27 | ROSMAP | Brain Pre-frontal Cortex | AP000662.4 | 0.05 | 0.01 | enet | 17 | 0.02 | 3.8e-04 | -5.15 | 5.2 | 2.1e-07 | -0.01 | 0.12 | 0.86 | FALSE |
28 | YFS | Blood | MED19 | 0.47 | 0.18 | enet | 73 | 0.28 | 7.1e-93 | 6.30 | 8.0 | 1.7e-15 | 0.00 | 1.00 | 0.00 | FALSE |
29 | YFS | Blood | SERPING1 | 0.04 | 0.04 | lasso | 6 | 0.04 | 1.2e-12 | -6.71 | -5.6 | 2.1e-08 | 0.05 | 0.98 | 0.02 | FALSE |
30 | YFS | Blood | ZDHHC5 | 0.06 | 0.07 | enet | 20 | 0.07 | 1.2e-22 | -7.74 | -7.2 | 5.6e-13 | 0.05 | 0.01 | 0.99 | FALSE |
31 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | MED19 | 0.07 | 0.01 | blup | 26 | 0.05 | 7.4e-05 | 6.19 | 7.8 | 6.4e-15 | 0.04 | 0.04 | 0.86 | FALSE |
32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MED19 | 0.05 | 0.03 | enet | 7 | 0.05 | 1.3e-10 | -7.88 | 8.5 | 1.9e-17 | 0.01 | 0.01 | 0.99 | FALSE |
33 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMX2 | 0.07 | 0.06 | lasso | 1 | 0.05 | 5.0e-04 | -8.00 | -8.0 | 1.2e-15 | 0.05 | 0.00 | 0.92 | FALSE |
34 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZDHHC5 | 0.10 | 0.05 | blup | 34 | 0.04 | 1.8e-03 | 6.19 | 5.8 | 6.3e-09 | 0.09 | 0.11 | 0.09 | FALSE |
35 | The Cancer Genome Atlas | Esophageal Carcinoma | MED19 | 0.10 | 0.06 | lasso | 4 | 0.02 | 5.4e-02 | -7.97 | 8.0 | 1.6e-15 | -0.05 | 0.00 | 0.86 | FALSE |
36 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MED19 | 0.03 | 0.01 | lasso | 2 | 0.02 | 1.9e-03 | -7.88 | 8.0 | 1.5e-15 | 0.00 | 0.01 | 0.66 | FALSE |
37 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MED19 | 0.15 | 0.05 | enet | 11 | 0.08 | 1.4e-09 | 6.29 | 5.3 | 1.2e-07 | 0.07 | 0.88 | 0.11 | FALSE |
38 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MED19 | 0.09 | 0.05 | lasso | 2 | 0.07 | 9.2e-05 | 6.19 | 8.1 | 8.3e-16 | 0.03 | 0.03 | 0.82 | FALSE |
39 | The Cancer Genome Atlas | Lung Adenocarcinoma | MED19 | 0.05 | 0.02 | blup | 26 | 0.03 | 6.0e-05 | -8.00 | 8.3 | 9.3e-17 | 0.01 | 0.00 | 0.99 | FALSE |
40 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MED19 | 0.03 | 0.02 | lasso | 1 | 0.01 | 1.8e-02 | -7.74 | 7.7 | 1.0e-14 | -0.06 | 0.01 | 0.84 | FALSE |
41 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MED19 | 0.13 | 0.06 | blup | 26 | 0.13 | 4.7e-06 | 6.19 | 8.1 | 3.9e-16 | 0.03 | 0.05 | 0.82 | FALSE |
42 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MED19 | 0.07 | 0.05 | blup | 26 | 0.05 | 4.4e-06 | 6.19 | 7.9 | 2.1e-15 | 0.04 | 0.47 | 0.46 | FALSE |
43 | The Cancer Genome Atlas | Prostate Adenocarcinoma | YPEL4 | 0.04 | 0.03 | lasso | 3 | 0.03 | 8.0e-04 | 5.58 | 6.8 | 9.6e-12 | 0.06 | 0.02 | 0.56 | FALSE |
44 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZDHHC5 | 0.10 | 0.11 | lasso | 3 | 0.11 | 2.9e-11 | 6.19 | 6.2 | 5.1e-10 | 0.08 | 1.00 | 0.00 | FALSE |
45 | The Cancer Genome Atlas | Soft Tissue Sarcoma | MED19 | 0.09 | 0.08 | lasso | 1 | 0.08 | 1.2e-05 | 6.19 | 6.2 | 5.9e-10 | 0.08 | 0.44 | 0.18 | FALSE |
46 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | MED19 | 0.10 | 0.04 | blup | 26 | 0.03 | 3.6e-02 | 6.19 | 8.0 | 1.0e-15 | 0.04 | 0.02 | 0.39 | FALSE |
47 | The Cancer Genome Atlas | Thyroid Carcinoma | MED19 | 0.10 | 0.05 | blup | 26 | 0.09 | 3.8e-09 | 6.19 | 8.0 | 9.1e-16 | 0.03 | 0.07 | 0.93 | FALSE |
48 | The Cancer Genome Atlas | Thyroid Carcinoma | SERPING1 | 0.06 | 0.03 | blup | 52 | 0.04 | 6.3e-05 | -6.59 | 5.7 | 1.1e-08 | -0.03 | 0.26 | 0.47 | FALSE |