[Hub]/) : Traits : Systolic Blood Pressure : ← →

chr11:62,922,117-66,333,072

Best TWAS P=1.34e-20 · Best GWAS P=7.62e-19 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CFL1	0.04	0.00	bslmm	350	0.02	3.3e-03	-1.2	-5.8	7.8e-09	0.17	0.10	0.17	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FIBP	0.08	0.11	enet	20	0.12	8.1e-14	5.4	5.2	1.6e-07	-0.05	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLA2	0.04	0.00	bslmm	352	0.01	6.6e-03	3.3	5.1	2.9e-07	-0.19	0.11	0.06	FALSE
4	CommonMind	Brain Pre-frontal Cortex	RNASEH2C	0.13	0.10	enet	14	0.10	4.3e-12	4.0	-6.0	1.6e-09	0.46	1.00	0.00	FALSE
5	CommonMind	Brain Pre-frontal Cortex	SNX32	0.46	0.36	lasso	8	0.39	1.9e-50	5.4	5.2	1.7e-07	-0.04	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	PRDX5	0.06	0.03	lasso	5	0.03	1.7e-03	4.7	-6.1	1.2e-09	-0.02	0.03	0.86	FALSE
7	GTEx	Adipose Subcutaneous	RNASEH2C	0.15	0.07	lasso	5	0.09	1.3e-07	4.0	-6.0	2.1e-09	0.43	0.41	0.57	FALSE
8	GTEx	Adipose Visceral Omentum	CTSW	0.22	0.20	lasso	11	0.19	5.1e-10	5.2	-5.3	1.4e-07	0.04	1.00	0.00	FALSE
9	GTEx	Artery Aorta	CTSW	0.29	0.26	lasso	7	0.25	3.2e-14	5.2	-5.2	2.4e-07	0.05	1.00	0.00	FALSE
10	GTEx	Artery Tibial	CTSW	0.12	0.09	enet	22	0.11	1.2e-08	5.2	-6.0	1.5e-09	0.05	1.00	0.00	FALSE
11	GTEx	Brain Hippocampus	CTSW	0.41	-0.01	enet	35	0.07	8.9e-03	-1.5	-5.3	1.0e-07	0.08	0.05	0.06	FALSE
12	GTEx	Breast Mammary Tissue	CTSW	0.25	0.19	lasso	8	0.16	1.3e-08	5.2	-5.4	6.9e-08	0.04	1.00	0.00	FALSE
13	GTEx	Breast Mammary Tissue	KAT5	0.15	0.06	lasso	10	0.02	2.1e-02	-7.3	-7.0	3.7e-12	0.66	0.10	0.07	TRUE
14	GTEx	Breast Mammary Tissue (Male)	KAT5	0.05	-0.01	lasso	4	-0.01	7.4e-01	-7.4	-5.6	2.7e-08	0.61	0.03	0.11	FALSE
15	GTEx	Breast Mammary Tissue (Female)	MAP3K11	0.18	0.11	enet	29	0.08	2.6e-03	4.0	5.5	3.1e-08	-0.36	0.12	0.05	FALSE
16	GTEx	Breast Mammary Tissue (Female)	PPP1R14B	0.10	0.06	lasso	2	0.08	2.0e-03	6.1	5.9	4.5e-09	-0.04	0.01	0.68	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	FIBP	0.40	0.21	enet	26	0.29	4.3e-10	5.2	5.9	4.4e-09	-0.05	0.99	0.00	FALSE
18	GTEx	Cells Transformed fibroblasts	FIBP	0.20	0.13	lasso	5	0.17	1.7e-12	5.2	5.9	3.0e-09	-0.09	1.00	0.00	TRUE
19	GTEx	Cells Transformed fibroblasts	CFL1	0.06	0.02	enet	12	0.01	1.1e-01	7.0	-6.9	6.7e-12	0.10	0.46	0.02	FALSE
20	GTEx	Cells Transformed fibroblasts	SIPA1	0.19	0.00	enet	30	0.05	2.5e-04	4.0	6.7	2.9e-11	-0.61	0.11	0.57	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	CTSW	0.18	0.15	lasso	2	0.14	1.2e-05	5.4	-5.7	1.5e-08	0.15	0.43	0.14	FALSE
22	GTEx	Esophagus Mucosa	CTSW	0.32	0.19	lasso	6	0.17	1.3e-11	5.2	-5.2	2.0e-07	0.05	1.00	0.00	FALSE
23	GTEx	Esophagus Mucosa	SIPA1	0.34	0.17	lasso	6	0.20	1.6e-13	-8.9	8.5	1.4e-17	-0.91	0.00	1.00	TRUE
24	GTEx	Esophagus Muscularis	FIBP	0.11	0.04	lasso	4	0.04	1.2e-03	7.0	7.2	7.4e-13	-0.10	0.69	0.01	FALSE
25	GTEx	Esophagus Muscularis	CTSW	0.29	0.32	lasso	5	0.32	2.9e-20	5.2	-5.6	1.7e-08	0.07	1.00	0.00	FALSE
26	GTEx	Heart Left Ventricle	FIBP	0.12	0.09	lasso	3	0.07	9.8e-05	5.2	5.4	7.7e-08	0.01	0.88	0.01	FALSE
27	GTEx	Liver	PPP1R14B	0.22	-0.01	enet	24	0.01	1.3e-01	-5.2	-6.0	2.5e-09	0.00	0.04	0.11	FALSE
28	GTEx	Muscle Skeletal	FIBP	0.12	0.13	enet	10	0.13	2.6e-12	5.2	5.6	1.8e-08	-0.05	1.00	0.00	FALSE
29	GTEx	Muscle Skeletal	CTSW	0.09	0.06	enet	20	0.05	1.9e-05	5.2	-7.0	3.2e-12	0.21	0.98	0.00	FALSE
30	GTEx	Nerve Tibial	PRDX5	0.10	0.01	lasso	5	0.04	9.8e-04	5.7	-5.2	2.2e-07	0.03	0.05	0.85	FALSE
31	GTEx	Nerve Tibial	SIPA1	0.17	0.01	enet	19	0.06	6.8e-05	-6.0	8.1	5.1e-16	-0.55	0.05	0.85	FALSE
32	GTEx	Pancreas	CTSW	0.13	0.11	lasso	3	0.08	4.0e-04	5.2	-5.3	9.3e-08	0.05	0.32	0.04	FALSE
33	GTEx	Prostate	CTSW	0.29	0.26	lasso	8	0.26	2.9e-07	5.2	-5.4	6.8e-08	0.06	0.57	0.03	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	PRDX5	0.13	0.12	lasso	2	0.11	1.5e-06	5.8	-5.5	4.0e-08	0.04	0.01	0.98	FALSE
35	GTEx	Skin Sun Exposed Lower leg	NAALADL1	0.08	0.00	lasso	7	0.00	3.2e-01	3.6	5.4	5.5e-08	0.01	0.00	0.04	TRUE
36	GTEx	Skin Sun Exposed Lower leg	RNASEH2C	0.18	0.12	lasso	5	0.12	5.7e-10	4.0	-5.2	2.5e-07	0.31	1.00	0.00	FALSE
37	GTEx	Spleen	CTSW	0.30	0.31	lasso	2	0.26	1.9e-07	5.2	-5.3	1.3e-07	0.05	0.97	0.00	FALSE
38	GTEx	Stomach	CTSW	0.18	0.20	lasso	7	0.19	1.7e-09	5.2	-5.2	2.0e-07	0.04	1.00	0.00	FALSE
39	GTEx	Testis	FIBP	0.21	0.22	lasso	5	0.19	6.5e-09	5.2	5.2	2.1e-07	-0.05	1.00	0.00	FALSE
40	METSIM	Adipose	FIBP	0.05	0.02	blup	344	0.02	1.0e-03	5.2	8.4	5.3e-17	-0.20	0.96	0.00	FALSE
41	METSIM	Adipose	NAA40	0.08	0.02	bslmm	332	0.05	2.8e-08	-4.4	-5.2	2.6e-07	0.03	0.09	0.91	FALSE
42	METSIM	Adipose	RNASEH2C	0.07	0.03	blup	325	0.04	3.4e-07	4.2	-5.5	3.1e-08	0.44	0.85	0.02	FALSE
43	METSIM	Adipose	VEGFB	0.12	0.06	enet	17	0.08	6.5e-12	4.7	-5.8	6.5e-09	0.01	0.87	0.13	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	MARK2	0.09	0.02	bslmm	324	0.03	8.0e-05	-4.2	-6.3	3.1e-10	-0.01	0.06	0.91	TRUE
45	ROSMAP	Brain Pre-frontal Cortex	FIBP	0.13	0.13	lasso	3	0.15	5.8e-19	5.2	5.8	8.9e-09	-0.09	1.00	0.00	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	CTSW	0.06	0.03	bslmm	328	0.03	3.6e-05	5.2	-8.4	5.9e-17	0.36	0.31	0.49	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	SNX32	0.50	0.53	lasso	13	0.54	1.1e-81	5.4	5.1	2.7e-07	-0.02	1.00	0.00	FALSE
48	YFS	Blood	FIBP	0.04	0.02	bslmm	343	0.03	6.4e-09	5.2	7.8	9.4e-15	-0.26	1.00	0.00	FALSE
49	YFS	Blood	GPR137	0.03	0.02	lasso	5	0.02	1.5e-08	6.1	6.5	1.1e-10	-0.04	0.00	1.00	TRUE
50	YFS	Blood	MUS81	0.04	0.02	blup	348	0.04	6.3e-12	3.2	-5.5	4.3e-08	-0.12	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CTSW	0.12	0.16	enet	12	0.17	5.6e-14	5.2	-5.1	3.0e-07	-0.01	0.99	0.01	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	CTSW	0.25	0.39	blup	44	0.41	7.3e-91	5.2	-5.3	1.4e-07	0.03	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	RNASEH2C	0.05	0.00	blup	32	0.02	1.1e-04	4.0	-8.9	6.7e-19	0.71	0.00	0.84	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	CTSW	0.40	0.34	enet	14	0.36	4.3e-22	5.4	-5.5	3.9e-08	0.14	1.00	0.00	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	RNASEH2C	0.11	0.03	enet	5	0.06	3.6e-04	4.0	-5.8	5.8e-09	0.42	0.01	0.69	FALSE
56	The Cancer Genome Atlas	Glioblastoma Multiforme	SNX32	0.13	0.05	blup	60	0.09	1.1e-03	5.4	5.5	5.2e-08	0.01	0.10	0.29	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SIPA1	0.06	0.04	blup	43	0.05	4.6e-06	-7.4	9.3	1.3e-20	-0.86	0.01	0.98	TRUE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SNX32	0.15	0.14	enet	8	0.15	2.5e-16	4.2	5.4	8.3e-08	-0.04	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CTSW	0.23	0.25	lasso	6	0.25	3.2e-28	5.2	-5.2	1.6e-07	0.05	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FIBP	0.04	0.02	blup	45	0.04	4.0e-05	5.4	6.2	4.6e-10	-0.08	0.02	0.96	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KCNK7	0.04	0.01	blup	42	0.01	1.2e-02	3.3	-6.3	2.3e-10	0.52	0.13	0.71	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP3K11	0.06	0.03	lasso	4	0.03	2.1e-04	-7.4	7.3	2.1e-13	-0.71	0.02	0.76	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RNASEH2C	0.15	0.05	blup	32	0.05	3.1e-06	4.0	-7.0	3.1e-12	0.62	0.60	0.04	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SIPA1	0.04	0.00	blup	43	0.02	6.2e-03	-8.9	8.8	8.7e-19	-0.80	0.00	0.71	TRUE
65	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX32	0.15	0.11	blup	60	0.15	6.0e-17	5.4	7.7	1.8e-14	-0.17	0.99	0.01	TRUE
66	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CTSW	0.32	0.26	lasso	1	0.26	4.3e-15	5.2	-5.2	1.7e-07	0.07	1.00	0.00	FALSE
67	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FIBP	0.05	0.01	blup	44	0.02	1.5e-02	5.4	6.5	6.0e-11	-0.05	0.03	0.55	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	EFEMP2	0.01	0.00	blup	45	0.01	3.0e-02	4.2	5.5	2.9e-08	0.03	0.02	0.47	FALSE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	FIBP	0.04	0.04	lasso	3	0.04	1.2e-05	5.4	5.8	6.2e-09	-0.04	0.26	0.72	FALSE
70	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CTSW	0.63	0.41	lasso	8	0.42	1.2e-21	5.2	-5.3	1.3e-07	0.06	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	CTSW	0.23	0.29	lasso	7	0.29	1.0e-33	5.2	-5.2	1.5e-07	0.05	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Lung Adenocarcinoma	FIBP	0.02	0.01	blup	45	0.02	1.3e-03	5.2	5.8	8.3e-09	0.00	0.07	0.41	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	SNX32	0.14	0.09	blup	60	0.13	8.8e-15	5.4	7.6	3.6e-14	-0.16	1.00	0.00	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SIPA1	0.09	0.03	blup	43	0.06	1.2e-07	-8.9	7.9	3.7e-15	-0.82	0.00	1.00	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	VEGFB	0.06	0.00	blup	47	0.02	3.9e-03	4.5	-5.7	9.5e-09	-0.01	0.01	0.63	FALSE
76	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CTSW	0.20	0.23	lasso	9	0.23	1.5e-15	5.2	-5.3	1.3e-07	0.05	1.00	0.00	FALSE
77	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SNX32	0.08	0.10	blup	60	0.11	6.0e-08	5.4	5.9	2.9e-09	-0.05	0.87	0.12	FALSE
78	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CTSW	0.30	0.23	lasso	11	0.24	1.7e-10	5.2	-5.3	1.3e-07	0.04	0.94	0.06	FALSE
79	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CTSW	0.16	0.10	enet	24	0.15	1.9e-06	5.4	-7.4	1.9e-13	0.09	0.04	0.94	FALSE
80	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SNX32	0.30	0.19	lasso	1	0.14	3.9e-06	5.4	5.4	5.3e-08	-0.03	0.77	0.11	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	CTSW	0.29	0.49	enet	12	0.49	3.4e-58	5.2	-5.3	1.3e-07	0.05	1.00	0.00	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	MAP3K11	0.06	0.02	blup	47	0.03	1.4e-04	-8.9	7.1	1.3e-12	-0.76	0.00	0.98	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	SNX32	0.07	0.08	lasso	4	0.10	2.0e-10	5.4	5.2	2.2e-07	-0.06	1.00	0.00	FALSE
84	The Cancer Genome Atlas	Rectum Adenocarcinoma	CTSW	0.21	0.05	blup	39	0.07	9.1e-03	5.2	-5.3	9.5e-08	0.00	0.05	0.24	FALSE
85	The Cancer Genome Atlas	Soft Tissue Sarcoma	CTSW	0.18	0.22	lasso	3	0.22	4.1e-13	5.2	-5.2	1.7e-07	0.04	1.00	0.00	FALSE
86	The Cancer Genome Atlas	Soft Tissue Sarcoma	FIBP	0.06	0.05	blup	45	0.04	1.2e-03	5.2	6.0	2.3e-09	-0.10	0.13	0.28	FALSE
87	The Cancer Genome Atlas	Soft Tissue Sarcoma	SNX32	0.08	0.08	lasso	2	0.10	1.5e-06	3.9	5.1	2.7e-07	0.08	0.52	0.42	FALSE
88	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SNX32	0.51	0.26	blup	60	0.36	1.9e-10	4.8	6.4	1.4e-10	-0.27	0.49	0.34	TRUE
89	The Cancer Genome Atlas	Stomach Adenocarcinoma	CTSW	0.24	0.35	lasso	7	0.36	3.0e-27	5.2	-6.2	6.6e-10	0.09	1.00	0.00	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	SNX32	0.12	0.13	blup	60	0.13	1.2e-09	5.2	6.5	6.7e-11	-0.12	1.00	0.00	FALSE
91	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SNX32	0.23	0.15	blup	60	0.12	6.3e-05	5.4	7.0	1.8e-12	-0.17	0.46	0.16	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	CTSW	0.25	0.37	lasso	8	0.37	5.2e-38	5.2	-5.3	9.5e-08	0.04	1.00	0.00	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	FIBP	0.04	0.00	blup	45	0.02	8.0e-03	7.1	8.0	1.8e-15	-0.21	0.01	0.49	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	SNX32	0.23	0.26	lasso	7	0.25	6.4e-24	5.4	6.1	1.4e-09	-0.04	1.00	0.00	FALSE
95	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CTSW	0.24	0.21	enet	21	0.24	2.9e-07	5.2	-6.0	2.6e-09	0.08	0.63	0.34	FALSE