Hub : Genes

CMTR2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1600	0.0620	2.7e-04	0.051	NA	0.021	NA	0.024	5.1e-05	NA	7.3e-03	NA	0.0041
2	GTEx	Adipose Visceral Omentum	0.2040	0.0750	9.2e-05	0.040	NA	0.125	NA	0.041	3.9e-03	NA	4.8e-07	NA	0.0034
3	GTEx	Artery Aorta	0.1630	0.0650	2.5e-04	0.044	NA	0.028	NA	0.026	1.8e-03	NA	1.1e-02	NA	0.0140
4	GTEx	Artery Tibial	0.0799	0.0369	1.5e-03	0.007	NA	0.006	NA	0.007	9.2e-02	NA	1.0e-01	NA	0.0850
5	GTEx	Cells EBV-transformed lymphocytes	0.1440	0.0700	9.9e-03	0.077	NA	0.074	NA	0.065	1.7e-03	NA	2.1e-03	NA	0.0038
6	GTEx	Cells Transformed fibroblasts	0.1170	0.0480	1.1e-03	0.006	NA	0.031	NA	0.017	1.0e-01	NA	2.2e-03	NA	0.0190
7	GTEx	Liver	0.1900	0.0930	7.6e-03	0.052	NA	0.019	NA	0.015	1.5e-02	NA	9.8e-02	NA	0.1200
8	GTEx	Lung	0.0924	0.0373	1.4e-04	0.003	NA	0.010	NA	0.014	1.8e-01	NA	5.6e-02	NA	0.0300
9	GTEx	Nerve Tibial	0.1053	0.0479	6.3e-04	0.001	NA	0.001	NA	0.004	2.6e-01	NA	2.7e-01	NA	0.1600
10	GTEx	Skin Not Sun Exposed Suprapubic	0.1030	0.0530	4.6e-03	-0.005	NA	-0.005	NA	-0.004	9.6e-01	NA	9.9e-01	NA	0.5900
11	METSIM	Adipose	0.0433	0.0191	3.5e-04	0.010	0.014	0.014	0.016	0.015	8.8e-03	0.0027	2.7e-03	0.0014	0.0019

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.6	1.0	3.0	-0.0	0.3	-1.5	-0.0	-1.4	1.7	0.4	1.0	0.6	1.2	0.7
Bipolar Disorder or Schizophrenia	1.1	2.7	14.3	-2.1	-1.6	-2.1	-1.1	-3.8	-0.7	-0.9	0.5	-0.0	0.3	-0.7
Depressed Affect (Nagel 2018)	6.2	13.1	26.8	-2.5	-3.2	-3.7	-4.1	-4.0	-2.2	-2.9	-3.3	-3.9	-3.8	-5.2
Depression (Nagel 2018)	5.3	8.0	17.2	-2.2	-2.5	-2.8	-3.0	-3.5	-1.6	-2.0	-2.3	-2.3	-3.7	-4.1
Intelligence (Savage-Jansen 2018)	1.6	4.9	10.4	3.0	2.1	0.9	3.0	1.0	0.6	2.5	2.2	0.6	2.9	3.2
Neuroticism (Nagel 2018)	5.1	11.9	24.1	-2.0	-3.3	-2.5	-3.7	-3.0	-3.5	-2.4	-3.9	-3.8	-4.0	-4.9
Schizophrenia (2018)	1.8	3.7	13.8	-2.6	-2.3	-1.6	-1.4	-3.7	-2.4	-1.5	-0.1	-0.5	-0.5	-1.5
Schizophrenia vs Biploar Disorder	1.6	2.2	5.8	-1.5	-1.2	0.1	-1.2	-1.2	-1.7	-2.4	-0.6	-0.4	-1.7	-2.2
Worry (Nagel 2018)	0.9	1.8	5.5	0.3	-0.9	0.5	-1.0	0.9	-1.1	0.1	-2.0	-1.8	-2.4	-1.8
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	-0.1	0.1	1.1	0.8	0.3	1.1	0.5	0.6	1.1	1.2	1.3
Alzheimer’s Disease (in father)	1.3	1.4	3.8	-0.4	-0.7	-0.9	-1.4	-1.9	-0.1	-1.4	-0.7	-1.1	-1.2	-2.0
Alzheimer’s Disease (including proxy)	0.4	0.6	2.7	-1.3	-0.5	-0.3	-0.7	-1.6	0.1	-0.9	-0.3	0.2	0.0	-0.6
Crohns Disease (2017)	0.1	0.1	1.3	-0.0	-0.3	0.1	0.0	-0.2	0.3	0.0	1.1	0.1	-0.1	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.5	-0.8	0.1	-0.4	-0.1	-0.5	-0.8	-0.2	-0.1	0.1	-0.5
Ulcerative Colitis (UC)	0.1	0.3	0.7	-0.5	-0.7	0.6	-0.3	0.5	-0.4	-0.6	-0.8	-0.1	0.4	0.0
Major Depression (MDD)	0.2	0.3	0.9	-0.0	-0.0	0.3	-0.2	-0.3	0.9	-0.6	0.6	0.1	-0.7	-0.5
Reaction Time	0.7	1.3	5.5	-1.5	0.7	-0.7	-0.6	-1.4	0.3	-1.7	-0.6	2.4	0.5	0.1
Verbal and Numeric Reasoning (VNR)	1.0	2.4	5.3	2.2	1.3	0.2	2.1	0.4	-0.2	2.3	1.8	-0.0	1.6	2.2
Breast Cancer	0.8	2.0	6.5	1.5	0.6	1.8	1.1	2.0	0.5	1.0	0.2	-2.6	-0.2	1.7
Ovarian Cancer	0.3	0.4	0.7	-0.4	-0.8	0.4	0.6	0.7	-0.7	0.7	0.1	-0.8	0.1	0.7
Prostate Cancer	0.9	1.3	3.3	-1.8	-0.4	-0.9	-1.2	-1.5	-0.9	-1.3	-0.0	1.0	-0.8	-1.3
Age at First Birth	3.3	4.8	10.1	0.5	2.4	1.4	1.9	1.2	3.2	0.6	2.5	3.0	2.3	2.8
Bipolar Disorder (2011)	0.6	0.6	3.1	-0.6	-0.7	-1.2	-0.4	-1.7	-0.6	0.2	0.8	0.4	0.2	-0.1
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	-0.6	-0.9	-1.2	-1.0	-0.9	0.4	-0.7	-1.3	-0.6	0.7	-0.8
Coronary Artery Disease (CAD)	0.6	0.8	2.4	-0.0	0.8	0.1	1.2	1.2	0.8	1.5	0.6	-0.6	-0.5	0.9
Crohns Disease (2012)	0.2	0.4	1.8	0.3	-0.0	0.1	0.6	0.4	0.1	0.2	1.4	0.7	0.9	0.7
Mean Putamen Volume	0.9	1.0	3.0	1.2	0.7	0.8	0.9	1.6	-0.9	1.7	-0.8	-0.0	0.2	0.9
Fasting Glucose	0.9	1.1	3.3	0.2	0.6	0.9	1.4	0.6	-0.6	-1.5	1.5	1.8	-0.1	0.7
HbA1C	0.5	0.6	1.5	1.1	1.0	-0.1	-0.0	0.8	0.7	-1.2	-0.2	-0.8	0.9	0.2
HDL Cholesterol	0.7	1.2	3.2	1.8	0.6	0.5	1.0	1.4	-1.3	1.2	-0.8	-1.5	0.3	0.8
LDL Cholesterol	5.2	8.2	16.3	2.1	2.9	1.9	3.4	2.1	3.5	0.9	3.6	2.9	2.6	4.0
Lupus	0.5	0.8	2.5	0.8	0.5	1.6	1.1	1.0	-0.3	1.0	1.1	-0.0	-0.2	0.7
Neuroticism (2016)	4.0	5.8	11.2	-0.6	-1.9	-1.7	-2.4	-1.9	-3.3	0.1	-3.3	-3.4	-2.6	-2.7
Primary Biliary Cirrhosis	0.8	1.2	3.1	0.8	0.7	1.3	1.8	1.3	-0.2	0.0	0.9	1.1	1.0	1.6
Rheumatoid Arthritis	0.3	0.4	1.4	-0.7	-0.3	-0.4	-0.8	-1.2	0.1	0.3	0.3	0.3	-0.4	-1.1
Schizophrenia (2014)	2.0	4.5	13.3	-3.2	-2.3	-1.6	-1.7	-3.6	-2.5	-2.1	-0.2	-0.3	-0.9	-1.8
Triglycerides	0.5	0.8	5.6	-0.4	0.3	-0.6	-0.2	-0.8	2.4	0.3	0.8	0.5	0.7	0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.4	-0.1	-0.0	1.5	1.1	0.3	-0.1	1.2	0.9	0.5	0.1	1.2
Ulcerative Colitis	0.3	0.4	1.1	0.0	0.4	0.8	-0.0	0.9	-0.0	-1.1	-0.6	0.8	0.6	0.3
Blood Eosinophil Count	0.4	3.3	6.2	-2.4	-1.6	-1.7	-1.6	-1.9	-1.5	-2.5	-1.2	0.6	-1.6	-2.3
Blood Platelet Count	0.3	3.0	14.7	-1.6	-1.1	-1.0	-1.4	-2.0	-3.8	0.5	-2.0	-0.3	-0.1	-1.9
Blood Red Count	1.1	10.5	34.5	1.3	4.0	2.6	3.0	1.2	2.2	0.7	3.9	5.9	2.4	4.5
Blood White Count	0.0	0.3	1.6	1.3	0.1	0.2	0.3	-0.1	-0.8	-0.1	-0.2	0.3	1.0	-0.0
Heel T-Score	0.2	1.7	7.0	-1.3	-0.1	1.4	0.3	0.1	-0.3	0.5	2.6	2.5	-0.8	0.8
BMI	0.5	3.0	13.0	0.1	1.0	-0.8	-1.4	-2.1	3.6	-1.6	-0.6	1.2	2.9	0.1
Height	0.6	11.9	27.4	-2.6	-3.8	-2.6	-2.8	-0.9	-3.9	-2.3	-3.2	-4.3	-4.1	-5.2
Waist Hip Ratio (WHR)	0.6	2.7	9.6	-0.7	-0.1	-0.2	-1.9	-0.6	-2.3	-1.9	-3.1	-1.9	-0.8	-1.7
Systolic Blood Pressure	2.9	14.7	28.2	5.3	4.0	4.2	4.4	4.5	1.8	2.6	3.2	2.7	3.4	4.7
Smoking Status	2.8	6.7	13.9	-2.4	-2.7	-3.7	-3.0	-3.3	-0.9	-1.8	-3.0	-2.9	0.2	-2.4
Allergy or Eczema	0.4	1.1	4.1	-0.1	1.1	1.1	0.9	0.8	1.4	-0.4	1.2	2.0	-0.3	0.5
Cardiovascular Disease	0.6	1.9	5.7	2.1	1.1	-0.4	0.8	0.9	2.3	0.6	-0.0	-0.2	2.4	1.6
Hypothyroidism (self reported)	0.2	0.4	2.0	0.2	-1.0	-0.2	-0.3	-0.4	0.0	0.9	-0.5	-1.4	-0.1	-0.1
Respiratory disease	0.7	1.6	4.8	0.1	-0.7	-0.6	-0.8	-0.0	-2.0	0.5	-1.4	-1.7	-1.6	-2.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.6	1.6	1.2	1.2	0.2	0.8	0.6	0.0	-1.0	-0.1	0.6	-0.2
Lung FEV1/FVC ratio	0.8	4.3	7.9	-1.5	-1.9	-1.8	-2.8	-2.5	-1.0	0.1	-1.8	-2.7	-2.3	-2.8
Lung FVC	0.6	3.0	14.7	-0.5	1.3	0.5	1.5	0.8	-0.1	-1.1	3.0	3.8	1.0	1.4
Neuroticism	4.2	10.2	19.1	-1.9	-2.9	-2.4	-3.7	-2.2	-3.3	-1.7	-4.0	-3.7	-3.6	-4.4
Chronotype (morning person)	1.2	2.7	12.0	2.1	1.0	2.4	1.8	3.5	-0.9	1.2	-0.2	-0.6	-0.5	0.4
Hair Pigment	0.0	0.8	2.0	1.2	1.4	-1.2	-0.3	0.0	-0.4	-0.5	-1.3	-1.0	0.2	0.4
Tanning	0.2	2.9	8.2	-2.7	-2.9	-1.0	-0.4	-1.5	-1.6	-0.3	2.3	1.8	-0.3	-1.1
Hand grip strength (left)	0.4	0.9	4.2	-0.0	0.2	-0.8	0.4	0.2	-0.6	1.6	0.5	-0.4	-2.1	-1.3
Number of treatments/medications taken	0.5	1.0	3.3	1.3	0.2	-1.8	-0.4	-0.2	0.8	-0.9	-1.1	-0.9	1.4	-0.2
Average weekly spirits intake	0.5	0.6	3.5	0.5	-0.2	-1.0	0.5	-0.9	-0.5	-0.6	0.3	0.2	1.9	0.4
Sensitivity / hurt feelings	1.1	1.9	5.0	-1.0	-1.1	-0.4	-1.1	-0.5	-2.2	-0.9	-1.9	-1.0	-1.7	-1.9
Frequency of depressed mood in last 2 weeks	2.1	2.9	6.2	-1.0	-1.4	-1.6	-1.7	-2.0	-0.8	-0.3	-1.7	-1.9	-2.5	-2.5
Hearing difficulty/problems: Yes	1.1	1.6	6.9	-1.3	0.1	0.1	-0.5	-1.0	1.7	-0.9	1.5	2.6	1.4	-0.5
Relative age of first facial hair	2.5	5.1	10.0	-1.2	-3.2	-1.9	-2.0	-2.5	-3.0	-1.8	-2.3	-3.0	-1.0	-2.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.9	-0.5	0.3	0.2	-1.2	-0.8	0.2	-1.4	-1.2	0.0	-0.7	-1.1
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.0	0.5	-1.4	-0.9	-0.8	-1.3	-0.4	0.2	-1.2	-1.3	-0.0	-0.8
Ever had hysterectomy (womb removed)	0.5	0.6	2.2	1.5	0.6	0.2	0.8	0.0	0.7	1.4	0.2	-0.7	0.7	0.5
Systolic blood pressure, automated reading	2.0	5.9	12.4	3.3	2.4	3.1	2.4	3.5	1.0	1.3	1.7	1.7	1.9	2.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	4.1	2.0	1.3	0.9	1.1	0.6	0.1	-0.4	0.5	0.1	0.9	0.5
Angina	0.1	0.2	0.8	0.3	0.2	0.2	0.2	-0.7	-0.4	-0.4	-0.2	-0.2	0.9	0.6
Medication for hormone replacement therapy	0.6	0.7	3.0	0.8	-0.6	-0.8	0.6	-0.3	-0.8	1.1	0.0	-1.7	-0.8	-0.0
Vitamin and mineral supplements	1.1	1.4	5.3	-0.2	0.2	1.0	0.2	0.2	1.4	0.6	1.0	2.2	2.3	1.0
Supplements: Zinc	0.7	0.8	2.7	-0.4	-0.6	-0.8	-1.1	-0.6	-0.0	-0.3	-0.8	-1.1	-1.7	-1.2
Medication: Co-codamol	1.2	1.4	3.4	0.5	-1.0	-1.5	-0.6	-1.7	-1.8	0.2	-1.2	-1.6	-0.2	-1.1
Medication: Metformin	0.3	0.5	2.2	1.5	0.7	0.8	0.2	0.7	0.6	-0.7	-0.2	-0.0	0.6	-0.3
Diabetes (father)	1.8	2.3	6.5	1.2	1.5	1.1	1.8	1.0	1.1	2.6	1.5	1.2	1.3	1.6
Diabetes (mother)	0.8	1.1	5.6	1.1	0.2	1.5	-0.1	0.8	-2.4	-0.8	-1.0	0.0	-0.0	-0.6
Severe depression (siblings)	0.9	1.0	4.5	0.4	-0.7	0.3	-0.4	0.0	-0.5	1.4	-1.1	-2.1	-1.3	-1.0
Pack years adult smoking proportion	0.4	0.7	2.5	1.6	0.9	0.8	0.3	0.4	1.0	0.0	-1.1	-0.7	0.7	0.0
Impedance of leg (right)	0.5	2.6	8.6	0.3	-0.8	1.6	0.6	2.2	-2.7	1.5	-0.8	-1.1	-2.9	-0.2
Leg fat-free mass (left)	0.5	2.8	6.1	-1.4	-1.3	-2.4	-2.0	-2.5	0.6	-1.6	-1.2	-1.1	0.6	-2.3
Trunk fat percentage	0.4	1.7	4.8	-0.7	-0.7	-1.3	-1.6	-2.2	1.1	-1.9	-0.9	0.6	1.4	-0.8
Hand grip strength (right)	0.4	1.0	5.6	0.8	0.7	0.2	1.2	1.0	0.1	2.4	1.1	-0.0	-0.8	-0.3
Townsend deprivation index at recruitment	1.3	1.9	5.2	-1.4	-1.0	-1.1	-1.8	-2.3	1.4	-1.3	-0.8	-1.4	-0.1	-1.4
Current tobacco smoking	1.4	2.4	4.5	-0.1	-0.9	-2.1	-1.9	-2.0	0.5	-1.7	-2.0	-1.6	1.0	-1.6
Average weekly fortified wine intake	0.3	0.3	1.0	-0.4	-0.2	0.2	-0.7	-0.6	0.2	0.9	0.0	-1.0	-0.6	-0.2
Maternal smoking around birth	0.6	0.8	3.6	-0.3	1.1	0.1	0.2	-0.9	1.9	-0.3	1.0	0.7	0.8	1.0
Fed-up feelings	4.3	7.8	16.1	-1.4	-2.9	-2.3	-2.8	-2.9	-2.8	-1.0	-2.8	-3.6	-2.8	-4.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	9.4	-1.1	-1.4	-1.4	-2.3	-2.0	-0.3	-1.8	-2.0	-1.5	-2.5	-3.1
Relative age voice broke	3.2	4.9	14.2	-0.8	-2.5	-0.7	-2.4	-1.4	-1.6	-0.6	-2.8	-3.8	-2.3	-2.9
Taking other prescription medications	0.2	0.3	1.3	1.1	-0.5	-0.2	-0.0	0.5	-1.1	0.2	-0.6	-0.4	-0.0	-0.5
Age when periods started (menarche)	0.9	2.2	7.8	1.7	1.5	1.3	2.4	2.8	-1.1	0.7	0.7	0.6	0.2	1.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	-0.0	-0.9	-0.4	-0.7	-1.0	-0.7	-0.0	-0.5	-0.3	-0.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	6.2	0.4	0.6	0.8	1.4	0.5	0.5	0.7	2.5	1.6	0.5	1.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.8	-0.9	-0.5	-0.0	0.3	-0.2	-0.8	0.5	0.4	-0.1	-0.3	0.3
Qualifications: CSEs or equivalent	1.6	2.1	6.0	0.1	-0.4	-0.3	-1.5	-0.0	0.9	-0.7	-2.5	-2.2	-2.2	-1.9
Serious illness, injury or assault to yourself	0.6	0.7	1.8	-0.0	-1.3	-0.2	-1.0	-0.2	1.0	-1.3	-0.8	-0.9	0.4	-0.5
High blood pressure	0.4	1.0	6.7	1.4	0.4	-1.0	0.1	0.2	0.3	-0.5	-0.7	-0.0	2.6	0.6
Hayfever, allergic rhinitis or eczema	0.3	0.8	3.2	0.1	0.8	0.6	0.8	0.9	1.3	-0.2	0.8	1.8	0.1	0.5
Multivitamins +/- minerals	1.3	1.7	4.6	-0.1	-0.5	-2.1	-0.5	-1.4	-1.2	-1.8	-1.0	-1.7	-1.5	-0.9
Stomach or abdominal pain in last month	1.2	1.5	4.1	-0.4	-1.8	0.2	-0.8	-0.5	-2.0	-1.6	-0.6	-1.0	-0.6	-1.8
Supplements: Glucosamine	0.3	0.4	1.1	0.4	-0.8	0.0	-0.2	0.1	-0.2	0.8	-0.3	-1.1	-1.0	-0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	4.3	-0.0	-0.0	2.1	0.4	-0.2	-0.7	0.0	0.6	0.5	-0.5	0.1
Medication: Atenolol	1.0	1.2	5.7	-0.3	-0.7	-1.3	0.4	-1.0	-0.5	-1.7	0.6	0.6	2.4	0.8
Medication: Levothyroxine sodium	0.4	0.7	1.9	0.0	-0.8	-1.3	-0.1	-1.0	-0.7	1.3	-0.6	-1.4	0.1	0.1
Sitting height	0.3	2.1	7.2	-2.1	-1.6	-2.7	-0.4	-1.3	-1.4	-1.5	0.4	0.4	-0.3	-1.5
Chronic bronchitis/emphysema (father)	1.8	2.1	10.5	0.8	1.0	2.0	1.1	1.6	0.7	3.2	0.8	0.6	-1.1	0.4
High blood pressure (mother)	0.2	0.3	1.9	0.3	0.2	-0.3	0.6	0.5	0.1	0.4	-0.3	0.5	1.4	0.7
Body mass index (BMI)	0.5	2.3	7.5	-0.6	-0.4	-1.3	-1.8	-2.7	1.9	-1.8	-0.7	0.6	2.1	-0.9
Impedance of leg (left)	0.8	3.7	12.0	0.8	-0.8	1.6	0.7	2.5	-3.3	1.6	-1.2	-1.8	-3.5	-0.4
Leg predicted mass (left)	0.5	2.8	6.1	-1.4	-1.3	-2.3	-2.0	-2.5	0.5	-1.6	-1.3	-1.1	0.7	-2.3
Trunk fat mass	0.5	2.2	5.8	-1.0	-1.0	-1.7	-1.9	-2.4	0.8	-2.1	-1.2	0.1	1.0	-1.5
Waist circumference	0.6	2.3	5.2	-0.8	-0.7	-1.2	-2.1	-2.3	0.5	-2.2	-1.8	0.1	1.9	-1.1
Number of incorrect matches in round	0.2	0.3	1.0	-0.0	0.2	0.3	0.5	0.2	0.2	0.1	0.1	0.9	0.7	1.0
Past tobacco smoking	0.8	1.5	7.3	0.9	1.4	2.7	0.9	1.6	0.3	0.0	1.0	1.1	-0.8	0.4
Alcohol usually taken with meals	0.7	1.2	4.1	0.1	0.7	1.8	1.2	2.0	-0.5	0.8	0.2	0.1	-0.1	1.8
Nervous feelings	1.6	2.9	6.2	-0.5	-1.5	-0.8	-1.9	-0.3	-1.9	-0.7	-2.4	-1.9	-2.5	-2.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	7.2	-0.9	-0.6	-0.2	-1.2	-0.4	-0.9	-1.2	-1.4	-0.8	-2.7	-1.5
Hearing difficulty/problems with background noise	1.1	1.7	5.0	-0.5	-1.7	-0.7	-1.8	-1.6	-0.2	-1.9	-0.7	-0.2	0.3	-2.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	0.6	-0.2	0.4	0.5	0.7	-0.1	0.5	0.8	-0.0	-0.1	0.5
Had menopause	1.3	1.6	5.1	-1.5	-2.3	-0.8	-1.2	-1.4	-1.6	-0.6	-0.0	-0.4	-1.5	-0.9
Had other major operations	1.9	2.3	6.3	-0.4	-1.2	0.8	-1.3	-1.0	-2.5	-0.3	-1.5	-2.1	-2.2	-1.7
Forced vital capacity (FVC)	0.3	1.2	4.8	0.0	0.5	1.0	1.4	2.2	-0.4	0.1	1.3	1.6	-1.1	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	8.4	0.6	0.7	1.4	1.7	0.9	0.1	1.2	2.9	1.7	0.7	2.0
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.6	-2.2	-1.5	-0.9	-1.3	-2.0	0.3	-0.9	-0.2	-0.6	-1.2	-1.1
Qualifications: None of the above	1.8	3.8	9.1	-2.7	-1.2	-1.1	-2.4	-3.0	-0.5	-2.6	-0.2	0.5	-1.6	-2.7
Financial difficulties in last 2 years	0.5	0.7	2.6	0.6	0.6	-0.5	0.7	0.1	1.4	0.1	0.3	-0.4	1.6	1.0
Mouth/teeth dental problems	0.6	1.0	3.8	1.2	0.3	0.9	1.1	0.8	0.9	1.9	0.8	-0.4	-0.2	0.9
Heart attack	0.1	0.2	0.6	-0.5	-0.4	-0.1	0.1	-0.2	0.6	0.0	-0.2	0.2	0.8	0.5
Allergy	0.1	0.2	0.9	-0.1	-0.0	0.2	-0.2	-0.4	-0.1	0.4	0.1	-0.4	0.9	0.5
Pain all over the body in last month	0.6	0.6	2.8	0.2	0.1	0.2	-0.8	0.4	0.3	-0.8	-0.9	-0.7	-1.7	-1.1
Diabetes (self-reported)	0.2	0.3	0.7	0.8	0.7	0.6	-0.3	-0.2	0.8	-0.6	-0.4	0.3	0.7	-0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.0	-0.6	-0.1	-1.0	-0.9	-0.1	0.4	-0.1	-0.7	0.1	-0.8	-0.9
Medication: Ramipril	0.5	0.7	2.0	1.0	1.4	0.7	0.3	0.2	1.2	0.3	-0.3	0.2	1.1	0.8
Medication: Simvastatin	0.3	0.4	1.1	-0.6	-1.0	-0.4	-0.2	-0.6	1.1	-0.6	0.2	0.1	0.8	0.8
Fluid intelligence score	0.6	1.2	3.5	1.9	0.7	-0.2	1.5	0.2	-0.3	1.0	1.0	-0.4	1.2	1.7
Illnesses of siblings	0.3	0.4	1.8	0.4	0.5	-0.2	-0.4	0.2	0.6	-0.2	-0.8	-1.3	-0.6	-0.3
Neuroticism score	3.1	6.5	14.3	-0.9	-1.9	-1.7	-2.6	-1.4	-2.7	-0.8	-3.2	-3.3	-3.5	-3.8
Weight	0.6	2.9	6.8	-1.2	-1.5	-2.1	-2.2	-2.6	0.7	-2.0	-1.4	-0.6	0.7	-2.2
Impedance of arm (right)	0.2	1.0	2.8	1.1	0.7	0.9	1.2	1.7	-0.1	0.9	-0.2	-1.2	-0.7	1.0
Arm fat percentage (right)	0.5	2.1	5.7	-0.2	0.1	-1.1	-1.5	-2.2	2.4	-1.7	-0.8	0.3	2.3	-0.2
Trunk fat-free mass	0.5	2.6	8.6	-1.2	-1.8	-1.7	-1.9	-1.5	-0.7	-0.8	-1.3	-1.8	-1.1	-2.9
Hip circumference	0.3	1.2	3.2	-0.1	-0.9	-1.0	-1.3	-1.4	1.8	-0.8	-0.8	-0.0	1.8	-0.6
Time employed in main current job	0.2	0.2	0.6	-0.0	-0.1	0.1	0.7	0.6	-0.1	-0.1	0.6	0.8	0.4	0.7
Alcohol intake versus 10 years previously	0.7	1.0	4.7	2.2	1.2	0.3	0.5	1.4	1.1	1.1	0.3	0.1	-0.7	-0.2
Father’s age at death	0.4	0.5	2.4	0.1	-0.1	1.6	0.1	0.8	-1.2	0.7	-0.5	0.2	0.1	0.3
Worrier / anxious feelings	0.5	1.0	2.1	-0.2	0.1	1.4	1.1	1.4	-1.3	0.7	1.0	0.9	-0.9	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	5.4	-0.5	-1.3	-0.5	-1.2	-0.9	-1.7	-0.7	-1.4	-1.4	-1.4	-2.3
Falls in the last year	3.0	4.1	7.6	-1.8	-2.8	-2.6	-2.2	-2.6	-1.1	-0.9	-2.4	-2.6	0.7	-1.0
Hair/balding pattern: Pattern 3	0.2	0.3	1.7	0.1	-0.2	-1.3	-0.4	-0.3	-0.1	0.5	-0.8	-0.2	-0.1	-0.8
Number of live births	0.7	0.9	5.9	0.2	-0.6	0.0	-0.7	-0.8	-2.4	-0.2	-0.2	-0.1	-0.8	-1.5
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.7	-0.6	0.0	0.9	0.7	1.5	-0.1	-0.1	1.1	1.2	-1.6	-0.6
Pulse rate	0.3	0.6	3.8	0.5	-0.0	0.7	0.4	-0.1	1.1	1.9	0.1	0.5	0.6	-0.0
Happiness	2.2	2.6	4.6	-0.7	-1.2	-1.8	-1.3	-1.8	-2.0	-0.2	-1.9	-2.1	-1.5	-2.1
Noisy workplace	0.2	0.3	0.5	-0.5	-0.2	0.2	-0.7	0.3	0.1	0.7	-0.7	-0.6	-0.4	-0.7
Qualifications: A levels/AS levels or equivalent	1.2	2.8	6.2	1.2	1.2	0.9	2.2	1.5	1.4	0.9	1.6	1.5	2.4	2.5
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.5	0.9	1.2	1.1	1.5	0.7	0.8	1.3	1.5	1.4	1.0	1.6
Mouth/teeth dental problems: Dentures	0.3	0.4	1.5	-0.1	0.0	-0.4	-0.0	0.0	-0.9	-1.1	0.5	1.2	0.9	-0.1
Asthma	0.3	0.5	1.6	-0.0	-0.7	-0.7	-0.5	-0.0	-0.5	0.2	-0.6	-1.1	-1.1	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	10.4	0.3	-0.2	-0.1	-0.4	0.5	3.2	-0.3	-0.6	-0.2	0.2	-0.1
Medication: Cholesterol lowering	2.0	3.1	10.4	1.2	1.5	0.8	1.5	1.0	3.2	-0.0	1.3	1.4	2.5	2.6
Depression (self-reported)	0.2	0.2	0.6	0.7	0.2	-0.1	0.8	0.3	-0.2	-0.5	0.4	-0.1	0.5	0.6
Medication: Lansoprazole	0.3	0.4	2.5	0.6	-0.1	-0.5	-0.5	-0.2	-0.2	0.1	-0.6	-1.6	0.2	-0.4
Prospective memory result	1.0	1.3	4.6	-0.9	-0.5	-1.4	-1.2	-0.9	-0.1	-1.1	-0.8	-0.2	-1.4	-2.1
Lung cancer (father)	0.7	0.8	2.9	1.0	1.0	0.4	0.9	0.9	1.1	1.7	0.8	0.1	-0.4	0.7
Illnesses of mother	0.2	0.3	1.3	0.3	0.4	-0.5	0.3	-0.3	0.1	-0.0	1.1	0.7	0.7	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.8	-0.0	0.9	1.0	1.2	1.2	-0.7	-0.3	1.4	1.7	-1.1	-0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.7	0.3	0.1	-0.2	-0.1	0.5	0.5	-0.6	-0.7	0.5	-0.2
Impedance of arm (left)	0.2	0.7	2.0	0.8	0.1	0.7	0.9	1.4	-0.3	0.8	-0.5	-1.4	-0.9	0.7
Arm fat mass (right)	0.6	2.4	6.6	-0.7	-0.7	-1.7	-2.0	-2.6	1.5	-2.0	-1.2	-0.1	1.7	-1.3
Trunk predicted mass	0.5	2.8	8.8	-1.2	-1.8	-1.7	-2.0	-1.5	-0.7	-0.8	-1.4	-1.8	-1.1	-3.0
Standing height	0.5	4.8	10.9	-1.3	-2.7	-1.9	-1.2	-0.3	-2.7	-0.5	-1.7	-2.9	-3.0	-3.3
Length of working week for main job	0.5	0.5	2.0	0.8	-0.7	-0.0	-0.5	-0.3	1.2	-0.1	-0.9	-1.4	0.2	-0.1
Exposure to tobacco smoke at home	1.1	1.2	4.2	1.4	2.0	1.4	0.8	1.1	1.2	0.3	0.5	0.8	0.6	0.7
Breastfed as a baby	0.5	0.6	1.3	-0.3	-0.7	-0.7	-0.8	-0.5	-0.3	-0.5	-0.4	-1.1	-1.1	-1.1
Tense / ‘highly strung’	4.4	7.3	16.8	-0.3	-2.3	-0.7	-2.4	-0.2	-2.7	-0.6	-3.6	-4.1	-4.0	-3.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.1	-0.0	0.1	-0.9	-1.2	-1.5	-0.4	-0.6	-1.4	-1.5	-1.2	-1.3
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	1.1	-0.0	1.5	0.9	1.4	1.4	0.4	0.7	-0.3	-0.1	0.5
Birth weight of first child	1.0	1.8	5.9	-0.9	-1.3	-2.4	-1.3	-1.6	-1.4	-0.0	-1.2	-1.5	-0.3	-1.2
Peak expiratory flow (PEF)	0.3	0.6	1.7	-1.1	-0.1	-0.7	0.6	0.3	0.4	-1.3	1.0	1.1	-0.8	-0.1
Pulse wave reflection index	0.4	0.5	2.4	0.0	0.4	-0.1	-0.0	-0.7	0.7	-0.9	0.8	0.3	1.5	0.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.2	-1.4	-0.1	-1.3	-1.0	-0.4	1.4	-1.5	-0.0	0.6	-0.6	-1.0
Loud music exposure frequency	1.7	1.8	4.0	-1.9	0.1	-1.2	-2.0	-1.2	1.3	-1.8	-0.9	0.7	-0.8	-1.6
Qualifications: O levels/GCSEs or equivalent	3.2	5.0	9.7	2.3	1.7	1.4	3.0	2.7	2.5	1.9	2.1	1.5	1.5	3.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.5	-0.2	0.4	-0.4	0.6	-0.3	-0.7	-0.4	-0.0	0.2	0.2	0.3
Blood clot in the leg (DVT)	1.6	2.0	7.0	-0.4	-0.2	0.1	-1.8	-0.3	-0.1	0.1	-2.2	-1.9	-2.7	-1.8
Medication: Paracetamol	1.7	2.8	6.1	-0.7	-1.6	-2.0	-2.5	-1.5	-0.6	-0.9	-2.2	-1.8	-0.8	-2.2
Headache pain in last month	0.2	0.3	1.1	0.4	-1.1	0.3	-0.3	0.4	1.0	-0.2	-0.3	-0.7	0.4	-0.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.7	-0.9	-0.9	-0.4	-0.7	-0.1	-1.9	0.6	-0.9	-1.0	-2.2	-1.7
Glaucoma (self-reported)	0.9	1.0	2.0	1.0	0.6	1.4	1.3	0.9	1.0	-0.2	1.4	0.9	0.7	1.1
Gout (self-reported)	1.1	1.5	3.4	-0.2	-1.7	-1.3	-1.5	-1.5	-0.7	-0.2	-1.8	-1.1	0.4	-1.5
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.3	-0.4	-1.3	-0.7	-0.3	-0.7	-0.9	1.5	-0.6	-1.8	-0.3	-0.2
Medication: Amlodipine	0.5	0.7	2.9	0.4	1.7	-0.4	0.2	-1.1	0.9	0.5	0.3	0.5	1.2	0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	0.7	0.6	-0.5	1.1	0.6	-0.8	-0.9	0.9	0.7	0.5	0.2
Birth weight	0.4	0.8	3.9	0.5	0.6	0.6	0.9	0.2	-0.3	-0.4	0.3	-0.1	2.0	1.6
Chronic bronchitis/emphysema (mother)	1.5	1.8	4.7	1.1	1.9	2.2	1.3	1.4	1.6	0.9	0.9	0.9	-1.1	0.8
High blood pressure (siblings)	0.2	0.3	0.9	-0.3	-0.8	-0.9	-0.1	-0.4	-0.4	-0.2	-0.4	0.5	1.0	-0.1
Forced vital capacity (FVC), Best measure	0.6	2.0	5.4	0.7	1.7	1.3	1.9	2.1	-0.2	-0.1	1.8	2.3	-0.8	0.2
Body fat percentage	0.4	1.5	4.4	-0.7	-0.6	-1.1	-1.6	-2.1	1.2	-1.8	-0.9	0.5	1.2	-0.7
Leg fat percentage (right)	0.5	1.9	5.2	-1.4	-1.1	-0.8	-2.1	-2.3	0.8	-1.7	-1.3	0.2	0.4	-1.2
Arm fat-free mass (right)	0.6	2.9	8.4	-1.5	-2.0	-1.7	-2.1	-1.8	-1.1	-1.2	-1.4	-1.2	-0.9	-2.9
Exposure to tobacco smoke outside home	1.1	1.5	4.4	2.1	0.8	1.2	2.0	1.1	0.3	-0.9	0.9	0.2	1.5	1.2
Comparative body size at age 10	0.6	1.6	11.6	-0.5	0.1	-0.1	0.2	-0.8	3.4	0.6	1.4	0.7	1.2	0.7
Number of full brothers	0.5	0.6	1.7	0.7	1.0	-0.7	0.9	0.4	1.3	-0.2	0.7	0.5	0.8	0.7
Worry too long after embarrassment	0.3	0.5	1.5	-1.0	-1.2	0.3	-0.5	-0.5	-1.2	-0.2	-0.8	-0.2	-0.9	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	4.5	-1.0	-0.7	-0.5	-0.2	-2.1	-0.2	-0.5	1.1	1.0	0.1	-0.1
Wheeze or whistling in the chest in last year	0.5	0.8	2.1	-0.2	-0.6	-1.1	-0.8	-0.7	-1.0	-0.9	-1.0	-0.7	-1.0	-1.5
Number of children fathered	1.6	1.8	4.9	-1.9	-0.4	-1.4	-1.3	-1.2	-1.1	-2.2	-0.7	0.7	-0.9	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	4.6	1.4	2.1	0.9	1.4	1.1	-0.4	0.5	0.9	2.1	1.1	1.2
Age at first live birth	3.3	5.9	14.7	1.1	2.2	1.3	2.8	2.8	2.9	1.6	2.4	2.8	1.9	3.8
Pulse wave peak to peak time	0.2	0.2	0.6	-0.8	-0.5	-0.1	0.1	0.2	-0.6	-0.5	0.4	0.5	-0.7	0.0
Health satisfaction	3.4	4.4	8.7	-1.8	-1.9	-1.1	-2.3	-1.7	-2.5	-1.1	-2.6	-2.2	-2.1	-2.9
Shortness of breath walking on level ground	1.6	1.8	5.9	-0.8	-1.2	-2.0	-0.9	-1.3	-0.9	-0.8	-1.7	-0.8	-0.8	-2.4
Qualifications: College or University degree	0.3	1.0	2.7	1.0	0.4	-0.3	1.0	0.5	-0.4	1.5	-0.3	-1.7	1.1	1.5
Eye problems/disorders: None of the above	1.3	1.6	7.7	-1.8	1.1	0.4	0.3	-0.5	0.7	-0.7	1.6	2.8	0.3	0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.5	-0.9	0.0	-0.4	-0.8	-0.3	1.2	-1.0	-0.9	0.5	0.5	-0.2
Emphysema/chronic bronchitis	0.3	0.4	2.6	0.1	-0.0	0.1	0.0	-0.5	-1.6	-0.6	-0.1	0.5	0.3	-0.5
Medication for pain relief, constipation, heartburn	0.9	1.5	5.2	0.0	1.0	1.0	1.6	0.3	-2.3	1.1	1.4	1.6	0.2	1.2
Neck or shoulder pain in last month	4.6	6.5	15.7	-1.9	-3.2	-1.1	-3.2	-2.5	-0.9	-1.4	-1.7	-2.7	-3.4	-4.0
Medication: Blood pressure	0.4	0.7	4.4	1.0	0.3	-0.5	0.2	-0.8	0.7	-0.8	0.4	0.4	2.1	0.7
Angina (self-reported)	0.2	0.2	0.7	0.1	0.1	-0.1	-0.1	-0.9	-0.3	-0.6	-0.4	-0.2	0.9	0.4
Migraine (self-reported)	0.9	1.1	3.4	1.8	1.3	0.5	0.6	1.7	1.3	-0.2	-1.0	-0.6	0.5	0.7
Medication: Ibuprofen	0.7	0.8	8.1	0.4	0.2	-0.2	-0.2	0.6	2.9	-0.3	-0.6	-0.2	-0.0	-0.2
Medication: Allopurinol	1.3	1.7	2.8	-0.2	-1.4	-1.2	-1.5	-1.6	-1.4	0.4	-1.7	-1.6	-0.1	-1.6
Medication: Omeprazole	0.1	0.1	0.3	0.3	-0.5	0.4	0.0	-0.0	-0.3	0.4	-0.4	-0.5	-0.3	-0.4
Medication: Seretide 50 evohaler	0.5	0.6	1.5	-0.3	-0.5	-1.0	-0.8	-0.6	-0.9	-0.4	-1.2	-0.7	-0.2	-0.9
Mean time to correctly identify matches	0.7	1.3	8.0	-1.8	0.6	-0.7	-0.5	-1.4	-0.1	-0.8	0.1	2.8	0.1	0.1
Heart disease (mother)	0.5	0.7	4.6	-1.2	-0.7	-0.1	-0.4	-0.4	0.1	-2.2	-0.3	0.1	0.3	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	4.9	-1.0	-1.3	-2.1	-0.7	-1.2	-2.2	-0.7	-1.2	-1.3	-1.2	-1.4
Whole body fat mass	0.5	2.2	5.9	-0.9	-1.1	-1.7	-2.0	-2.4	1.1	-2.0	-1.2	-0.0	0.9	-1.5
Leg fat mass (right)	0.6	2.2	6.1	-1.1	-1.1	-1.3	-2.2	-2.5	0.9	-1.7	-1.4	-0.1	0.7	-1.6
Arm predicted mass (right)	0.7	3.5	9.4	-1.6	-2.1	-2.0	-2.3	-2.0	-1.3	-1.4	-1.6	-1.2	-0.9	-3.1
Pulse rate, automated reading	0.3	1.0	3.3	1.1	0.5	0.4	-0.5	-1.2	1.6	1.8	0.3	0.5	0.3	-1.0
Alcohol intake frequency.	0.7	1.7	6.9	1.2	0.5	0.4	-0.3	0.5	0.6	2.3	-0.4	-1.2	-2.6	-1.4
Comparative height size at age 10	1.0	5.2	15.8	-1.8	-2.3	-1.9	-2.7	-1.8	-1.5	0.3	-1.8	-2.6	-2.5	-4.0
Number of full sisters	1.1	1.3	3.0	-0.8	-1.2	0.0	-1.6	-0.7	-0.8	0.5	-1.6	-1.7	-1.0	-1.4
Suffer from ‘nerves’	0.3	0.4	1.0	0.9	0.7	0.9	0.4	1.0	0.8	0.6	0.0	-0.1	-0.5	-0.2
Overall health rating	1.9	4.2	10.7	-0.9	-1.4	-1.4	-2.4	-2.3	-2.9	-1.4	-2.5	-1.4	-0.9	-3.3
Chest pain or discomfort	2.6	3.8	11.5	-0.2	-1.5	-0.5	-1.6	-0.6	-2.7	-2.2	-3.4	-2.6	-1.2	-2.1
Had major operations	2.1	2.5	4.8	1.9	1.0	2.0	1.8	1.7	1.7	2.2	1.5	-0.3	-0.1	1.5
Age at last live birth	1.6	2.3	6.1	0.9	1.2	0.4	2.0	1.1	1.7	1.0	1.3	1.5	1.9	2.5
Family relationship satisfaction	0.3	0.4	1.4	0.1	0.7	0.1	-0.1	-0.6	-1.2	-1.0	-0.4	0.9	0.1	-0.7
Leg pain on walking	0.8	1.1	2.6	-0.1	-1.1	-0.2	-0.8	-0.6	-0.4	-1.3	-1.1	-1.6	-1.3	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.1	-0.4	-0.9	1.4	0.3	1.0	-0.3	0.3	0.1	0.0	-0.8	0.2
Commuting to job workplace: Car/motor vehicle	3.3	3.8	7.2	-2.2	-2.7	-1.6	-2.1	-2.1	-0.4	-2.2	-0.6	-0.7	-2.5	-2.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.0	0.2	0.4	1.3	0.6	0.8	-1.3	1.4	0.3	0.6	-0.6	-0.1
Medication: Aspirin	2.4	3.2	7.0	-1.1	-1.8	-2.6	-1.9	-1.9	-0.6	-2.3	-2.1	-1.9	0.0	-1.7
Supplements: Vitamin C	1.9	2.3	9.4	-0.2	-1.2	-0.4	-1.0	-0.4	-0.6	0.8	-1.3	-3.1	-2.8	-1.5
Knee pain experienced in last month	0.7	1.1	3.6	-0.3	-1.9	-0.1	-1.0	-0.0	-0.6	-0.4	-0.6	-0.6	-1.5	-1.9
Hypertension (Self-reported)	0.4	1.0	6.0	0.9	0.3	-1.3	-0.4	-0.3	0.6	-1.0	-0.8	0.0	2.5	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.7	0.5	-0.0	-0.6	-0.7	0.2	-0.9	-0.5	-0.8	-1.2	-0.8	-1.3
Illnesses of father: Heart disease	3.6	4.9	11.8	-2.2	-1.9	-3.4	-2.3	-3.1	-2.0	-2.3	-2.1	-1.4	-0.3	-2.0
Illnesses of siblings: Diabetes	1.5	1.9	7.0	0.1	0.7	0.9	1.0	0.2	1.0	-0.9	1.1	2.3	2.6	1.8
Smoking status: Previous	0.2	0.4	1.7	-1.0	-0.6	-1.3	-0.3	-0.6	0.3	0.1	-0.1	-0.2	0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.8	1.6	0.0	0.4	0.4	1.6	0.8	1.3	-0.9	-1.9	-0.2	-0.3
Whole body fat-free mass	0.5	2.7	7.6	-1.3	-1.7	-2.0	-2.0	-2.0	-0.4	-1.2	-1.3	-1.5	-0.4	-2.8
Leg fat-free mass (right)	0.5	2.5	5.3	-1.1	-1.2	-2.3	-1.8	-2.3	0.2	-1.5	-1.2	-1.3	0.4	-2.3
Arm fat percentage (left)	0.6	2.3	5.7	-0.3	-0.2	-1.3	-1.6	-2.3	2.4	-1.9	-0.9	0.3	2.2	-0.4
Average weekly red wine intake	0.3	0.4	1.1	-1.0	-1.0	-0.6	-0.2	-0.5	0.0	-0.9	-0.1	-0.3	1.0	0.1
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.3	-0.9	-0.4	-1.1	-1.2	-0.9	-1.8	-0.8	-1.5	-1.0	-1.6	-1.7
Mood swings	7.0	12.7	24.4	-3.0	-3.2	-3.1	-4.3	-3.6	-2.7	-2.1	-3.6	-3.9	-4.0	-4.9
Loneliness, isolation	3.9	5.4	10.0	-1.8	-1.5	-2.6	-2.6	-2.5	-1.2	-1.9	-2.3	-2.1	-3.0	-3.2
Long-standing illness, disability or infirmity	0.6	0.9	2.4	-0.7	-1.1	-0.3	-1.2	-1.4	-0.0	-1.6	-0.9	-0.7	0.7	-0.8
Ever had bowel cancer screening	0.3	0.3	1.0	0.3	0.1	1.0	0.5	0.2	-0.0	0.4	1.0	0.8	-0.3	0.1
Diabetes diagnosed by doctor	0.3	0.5	1.3	1.1	0.8	0.8	0.1	0.4	0.2	-0.7	-0.7	0.3	1.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	6.5	1.9	-0.6	-0.2	-0.1	0.6	1.0	0.4	-1.1	-2.5	-1.3	-0.8
Friendships satisfaction	2.1	2.6	8.9	-1.3	-1.0	-1.8	-1.1	-2.0	-3.0	-1.9	-1.7	-0.2	-0.1	-1.5
Qualifications: nursing, teaching	0.4	0.6	2.0	0.2	-0.2	-1.2	0.4	-0.3	0.8	0.9	0.1	-0.2	1.4	1.0
Commuting to job workplace: Walk	2.6	2.8	5.8	1.0	1.1	2.1	1.6	2.3	1.9	2.4	1.6	0.4	0.2	1.9
Eye problems/disorders: Cataract	1.1	1.3	3.5	1.9	-0.4	-0.1	0.1	1.6	1.0	1.0	-1.4	-1.8	0.8	0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.0	-0.6	0.4	0.0	-0.7	0.0	0.5	-1.0	-0.8	0.4	0.9	0.1
Medication for cholesterol	0.4	0.6	1.6	-1.1	-0.3	0.7	-0.7	0.1	1.2	-0.5	-0.1	0.0	-1.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	3.2	-0.5	-1.1	1.0	-0.1	0.3	0.0	-0.4	0.1	-1.4	-1.8	-0.4
Back pain experienced in last month	2.8	4.1	9.7	-2.3	-2.5	-1.8	-2.6	-2.5	-1.6	-0.8	-1.3	-0.6	-1.5	-3.1
Mineral and other dietary supplements	0.7	0.9	3.0	-0.0	0.5	1.6	0.5	-0.0	0.9	-0.3	0.8	1.2	1.7	1.1
Breast cancer (self-reported)	0.4	0.5	2.6	0.5	1.1	0.7	0.3	0.2	0.2	0.3	0.6	1.6	0.6	-0.4
Asthma (self-reported)	0.4	0.7	2.2	-0.2	-0.8	-1.0	-0.6	-0.2	-0.8	0.0	-0.7	-1.0	-1.3	-1.5
Osteoporosis (self-reported)	4.2	5.2	9.9	-2.6	-2.2	-2.7	-3.1	-2.2	0.1	-2.0	-3.0	-1.9	-1.5	-2.0
Osteoarthritis (self-reported)	0.7	1.0	4.2	-0.9	-1.0	-1.4	-0.9	-2.1	0.7	-0.7	0.2	0.5	0.7	-0.3
Medication: Aspirin	1.5	1.9	5.6	-1.2	-1.2	-2.2	-1.3	-1.6	-0.7	-2.4	-1.2	-0.7	0.4	-1.0
Medication: Gliclazide	1.9	2.1	5.2	-1.3	-1.1	-0.8	-1.9	-0.9	-1.2	-1.1	-1.4	-1.4	-1.8	-2.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	0.3	0.5	0.0	-0.1	0.6	0.0	-0.6	-0.6	-0.4	-0.2	0.1
Smoking status: Current	1.7	2.7	5.3	-0.2	-1.2	-2.3	-1.9	-2.0	-0.0	-1.5	-2.3	-2.0	0.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.9	0.8	1.5	1.5	1.3	1.0	-1.4	-0.3	1.8	2.0	-0.4	0.2
Whole body water mass	0.5	2.8	7.7	-1.3	-1.6	-2.1	-2.0	-2.1	-0.3	-1.2	-1.4	-1.5	-0.4	-2.8
Leg predicted mass (right)	0.5	2.8	5.9	-1.2	-1.4	-2.4	-1.8	-2.4	0.0	-1.5	-1.3	-1.4	0.4	-2.4
Arm fat mass (left)	0.6	2.6	7.4	-0.8	-0.8	-1.8	-2.1	-2.7	1.5	-2.0	-1.2	-0.1	1.5	-1.4
Number of self-reported non-cancer illnesses	0.4	0.8	2.2	0.3	-0.4	-1.5	-0.9	-1.0	0.3	-0.3	-1.4	-1.0	0.8	-0.6
Average weekly champagne plus white wine intake	0.4	0.5	1.9	-0.2	-1.4	0.7	-0.3	0.8	-0.6	0.3	-0.7	-1.2	-0.7	-0.1
Miserableness	1.4	2.5	5.1	-1.4	-1.1	-1.7	-1.7	-2.3	-0.4	-1.5	-1.4	-1.6	-1.5	-2.0
Guilty feelings	3.1	4.7	14.2	-1.2	-1.7	-1.4	-2.5	-1.6	-3.8	-0.8	-2.4	-1.9	-2.4	-2.7
Wears glasses or contact lenses	0.8	0.9	2.5	-0.2	-0.9	-0.8	0.5	-1.1	-1.6	-1.5	0.6	-0.7	0.7	0.7
Ever taken oral contraceptive pill	0.3	0.3	1.0	0.2	-0.3	0.5	-0.1	0.7	1.0	0.5	-0.6	-1.0	0.2	0.1
Hearing aid user	0.3	0.3	1.1	-0.4	-0.0	-0.7	-0.4	-0.9	-0.7	-1.0	0.4	0.0	0.1	-0.4
Mother’s age at death	1.1	1.4	6.9	-0.8	0.2	0.2	1.0	0.5	0.2	0.1	2.2	2.6	0.5	1.3
Financial situation satisfaction	1.9	2.3	5.2	-1.6	-0.5	-2.3	-1.7	-1.9	-0.8	-2.0	-1.5	-0.9	-0.4	-1.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.2	-0.9	0.7	-0.3	-0.2	-0.1	-0.0	-1.0	0.4	1.2	1.5	0.5
Commuting to job workplace: Public transport	1.4	1.7	4.5	2.1	1.0	1.2	1.4	1.6	-1.4	1.1	-0.8	-0.5	1.3	1.3
Eye problems/disorders: Glaucoma	1.0	1.1	3.0	1.6	0.6	1.3	1.7	1.3	-0.0	-0.1	1.3	0.6	0.3	1.0
Medication: Blood pressure	0.4	0.8	3.0	-0.0	0.1	-1.7	-0.7	-0.8	-0.8	-0.3	-1.1	0.4	1.7	0.3
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.2	-0.1	-1.8	-1.5	-1.1	-1.0	-1.0	0.1	-1.3	-0.8	-0.2	-1.6
Supplements: Fish oil (including cod liver oil)	0.7	1.0	3.2	-0.1	-0.2	-1.7	-0.5	-0.1	-1.2	0.2	-0.3	-0.7	-1.8	-1.4
High cholesterol (Self-reported)	0.8	1.4	3.7	0.4	1.3	-0.1	0.8	0.5	1.3	-0.9	1.1	1.9	1.6	1.9
Medication: Bendroflumethiazide	0.7	1.0	3.4	0.0	0.2	-0.9	-0.4	-0.0	1.4	-1.3	-0.5	1.3	1.8	1.1
Medication: Paracetamol	1.3	2.0	4.7	-0.1	-1.2	-1.6	-1.9	-0.9	-0.8	-1.2	-2.2	-1.6	-0.2	-1.9
Medication: Lisinopril	0.8	1.0	8.6	0.6	-0.3	-0.3	0.4	0.1	0.0	-0.5	0.4	0.4	2.9	1.3
Medication: Atorvastatin	2.1	2.6	6.7	0.7	1.4	1.2	1.8	1.0	1.9	0.6	1.6	1.9	1.9	2.6
Illnesses of father: High blood pressure	1.7	2.1	5.4	2.0	1.3	1.2	1.7	1.3	0.4	-0.2	0.8	1.3	2.3	1.7
Alcohol drinker status: Never	1.2	1.5	2.8	0.7	0.7	1.7	1.3	1.5	1.3	1.3	1.6	1.1	0.4	1.1
Ever smoked	1.4	2.5	9.2	-0.8	-1.8	-3.0	-1.3	-2.3	-0.6	-0.8	-1.8	-1.5	0.9	-0.8
Basal metabolic rate	0.5	2.7	7.1	-1.2	-1.6	-2.0	-2.1	-2.2	-0.1	-1.4	-1.4	-1.4	-0.2	-2.7
Leg fat percentage (left)	0.4	1.5	4.2	-1.0	-1.0	-0.8	-1.9	-2.1	0.6	-1.6	-1.3	0.0	0.2	-1.2
Arm fat-free mass (left)	0.6	3.0	7.9	-1.5	-1.9	-1.8	-2.1	-2.2	-0.9	-1.2	-1.3	-1.2	-0.8	-2.8
Number of operations (self-reported)	1.1	1.7	4.8	2.2	-0.2	1.3	0.3	0.7	-0.7	1.8	-0.9	-2.2	-1.4	-0.7
Average weekly beer plus cider intake	1.1	1.6	3.7	-0.3	-0.9	-1.9	-1.0	-1.9	-1.4	-1.4	-1.0	-0.6	-0.3	-1.6
Irritability	9.6	16.2	30.8	-1.5	-3.9	-4.0	-4.3	-3.4	-4.0	-0.8	-5.1	-5.1	-4.0	-5.5
Risk taking	5.5	8.0	17.4	-1.3	-1.5	-2.4	-3.8	-2.9	0.3	-2.8	-3.8	-4.2	-2.3	-3.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	3.1	-0.1	0.3	0.1	-0.4	0.0	1.8	0.3	0.8	1.0	-0.4	-0.1
Fractured/broken bones in last 5 years	5.8	7.4	17.1	-1.5	-2.8	-3.1	-2.9	-2.0	-0.2	-2.2	-4.1	-3.6	-1.9	-3.3
Age started oral contraceptive pill	2.6	3.3	7.2	2.0	1.4	1.7	2.7	1.6	-0.3	1.3	2.2	1.6	1.4	2.5
Diastolic blood pressure, automated reading	0.7	2.2	10.4	1.3	1.5	-0.2	1.3	0.8	1.5	-0.8	0.6	0.8	3.2	2.0
Ever depressed for a whole week	0.3	0.4	1.3	-0.8	-0.1	-0.1	-0.4	-0.8	0.8	1.1	0.3	-0.5	-0.6	-0.7
Unable to work because of sickness or disability	0.4	0.5	3.0	0.6	0.2	-0.2	0.4	-0.5	-0.6	-1.7	0.7	0.6	0.2	-0.3
Commuting to job workplace: Cycle	2.5	3.1	9.9	1.6	1.6	-0.2	1.2	1.1	3.0	-0.3	1.3	1.5	3.1	1.9
Myopia	0.2	0.4	1.1	0.7	0.2	-0.3	-0.2	-0.4	-1.1	-0.5	-0.9	-0.9	0.4	-0.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	6.2	-0.9	-0.3	0.9	-0.2	0.1	-0.2	0.8	0.5	-0.1	-2.5	-0.7
Cholesterol lowering medication	0.2	0.3	0.7	-0.4	-0.3	-0.2	0.2	-0.7	-0.8	-0.7	0.7	0.8	0.2	0.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.4	0.9	0.5	0.9	1.2	0.7	0.5	0.5	0.8	0.5	0.2	0.6
Pain experienced in last month	1.0	1.7	4.8	0.6	2.1	-0.5	1.3	0.4	1.2	0.6	0.7	1.2	1.8	2.2
Supplements: Calcium	0.7	0.7	1.8	-0.3	-0.4	-1.3	-0.4	-0.4	-0.8	0.5	-1.0	-1.3	-1.4	-0.6
Basal cell carcinoma (self-reported)	0.7	0.8	2.7	0.6	0.7	0.2	1.0	-0.5	0.2	-0.3	1.6	1.1	1.1	1.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.7	-0.7	-0.7	-0.3	-0.1	-0.5	0.5	-0.1	-0.3	0.0	0.8	0.4
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	6.8	-0.2	0.1	0.2	-1.8	-0.3	-0.0	0.5	-2.3	-1.9	-2.6	-1.9
Heart disease (siblings)	0.4	0.5	1.8	-0.5	0.1	0.6	0.4	-0.6	-0.5	-0.8	1.1	1.3	-0.0	-0.1
Alcohol drinker status: Previous	1.2	1.4	3.9	0.3	0.2	-0.4	-0.9	-1.0	0.5	1.6	-1.2	-2.0	-1.8	-1.3
Pack years of smoking	0.3	0.5	1.5	1.2	0.8	0.8	0.5	0.4	1.0	-0.1	-0.5	-0.1	0.9	0.4
Impedance of whole body	0.3	1.5	4.7	0.6	-0.6	0.9	0.8	1.7	-2.2	0.8	-0.7	-1.3	-2.1	0.1
Leg fat mass (left)	0.5	2.0	5.6	-1.0	-1.1	-1.3	-2.1	-2.4	0.7	-1.8	-1.3	-0.2	0.6	-1.6
Arm predicted mass (left)	0.5	2.5	7.5	-1.3	-1.7	-1.7	-2.0	-2.0	-0.7	-1.1	-1.1	-1.1	-0.8	-2.7