Hub : Genes

IL34

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0180 0.0120 1.7e-02 0.017 0.007 0.005 0.006 0.006 2.8e-03 4.1e-02 7.2e-02 0.06 6.1e-02
2 GTEx Adipose Subcutaneous 0.0440 0.0260 6.6e-03 -0.003 NA 0.001 NA -0.001 7.5e-01 NA 2.5e-01 NA 3.7e-01
3 GTEx Brain Putamen basal ganglia 0.2570 0.1020 1.6e-03 0.078 NA 0.108 NA 0.120 6.8e-03 NA 1.6e-03 NA 9.0e-04
4 GTEx Esophagus Mucosa 0.0440 0.0240 7.2e-03 0.063 NA 0.048 NA 0.058 5.2e-05 NA 3.6e-04 NA 9.3e-05
5 GTEx Lung 0.1971 0.0544 4.0e-08 0.145 NA 0.127 NA 0.146 3.3e-11 NA 5.8e-10 NA 2.8e-11
6 GTEx Nerve Tibial 0.0725 0.0347 3.8e-04 0.071 NA 0.049 NA 0.061 9.0e-06 NA 2.1e-04 NA 4.1e-05
7 TCGA Glioblastoma Multiforme 0.1030 0.0600 8.8e-03 0.043 0.028 0.008 NA 0.027 2.0e-02 4.8e-02 1.8e-01 NA 5.0e-02
8 TCGA Head and Neck Squamous Cell Carcinoma 0.0476 0.0260 7.1e-03 0.009 0.010 0.002 NA 0.004 2.9e-02 2.3e-02 1.9e-01 NA 1.2e-01
9 TCGA Kidney Renal Clear Cell Carcinoma 0.0409 0.0210 2.8e-04 0.009 0.029 0.004 NA 0.011 3.2e-02 2.9e-04 1.0e-01 NA 1.7e-02
10 TCGA Prostate Adenocarcinoma 0.0411 0.0263 5.2e-03 0.008 0.020 0.004 NA 0.004 4.4e-02 3.2e-03 1.3e-01 NA 1.1e-01
11 TCGA Stomach Adenocarcinoma 0.1430 0.0570 3.9e-05 0.044 0.073 0.088 NA 0.075 3.7e-04 5.6e-06 6.4e-07 NA 4.4e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 2.4 3.9 10.3 1.6 -0.9 2.4 -0.4 2.5 -0.6 -3.2 0.5 -3.1 2.6 0.3
Bipolar Disorder or Schizophrenia 0.4 0.9 3.2 0.7 -0.2 -0.4 -0.1 1.6 -0.3 -1.8 0.2 -1.7 0.8 -0.6
Depressed Affect (Nagel 2018) 1.7 3.5 10.8 -2.3 0.8 -0.9 0.4 -3.3 0.4 2.7 1.6 2.8 0.5 1.9
Depression (Nagel 2018) 1.3 2.0 5.4 -1.2 0.2 -2.3 -0.1 -2.3 -0.1 1.9 0.6 2.1 -0.6 1.1
Intelligence (Savage-Jansen 2018) 1.9 5.9 21.5 0.4 1.5 2.1 1.9 1.7 2.0 -3.5 2.1 -2.1 4.6 2.4
Neuroticism (Nagel 2018) 1.5 3.6 11.2 -2.7 0.4 -0.5 0.0 -3.3 0.1 2.9 1.5 2.7 0.5 1.7
Schizophrenia (2018) 0.4 0.8 5.9 -0.4 0.4 -2.4 0.2 0.1 0.1 0.3 -0.1 0.3 -1.1 -1.0
Schizophrenia vs Biploar Disorder 2.4 3.1 7.0 -2.0 1.5 -2.6 0.6 -1.8 0.8 2.6 -0.0 2.6 -1.9 0.3
Worry (Nagel 2018) 1.0 2.1 6.3 -2.0 0.4 0.3 -0.1 -2.5 -0.1 2.1 1.1 1.9 0.9 1.7
Alzheimer’s Disease (in mother) 1.6 1.9 5.1 -0.6 -1.4 1.6 -1.2 -2.3 -1.3 2.3 0.4 0.9 0.9 1.1
Alzheimer’s Disease (in father) 4.4 4.7 8.2 -2.8 2.3 -2.0 2.0 -2.5 1.9 2.3 0.8 2.6 -0.1 2.9
Alzheimer’s Disease (including proxy) 3.4 4.9 20.3 -2.3 -0.1 -0.6 -0.3 -3.8 -0.7 4.5 0.0 2.9 -1.4 1.7
Crohns Disease (2017) 1.3 2.8 7.2 1.4 -2.5 -1.1 -1.3 2.1 -1.5 -0.3 -1.8 -0.8 -2.7 -1.3
Irritable Bowel Disease (IBD) 0.3 0.6 3.5 -0.4 -1.0 -0.8 0.2 0.7 -0.2 0.8 -0.0 0.4 -1.9 -0.4
Ulcerative Colitis (UC) 0.2 0.4 1.2 -1.1 0.3 0.1 0.9 -0.1 0.6 0.9 0.6 0.6 -0.6 0.4
Major Depression (MDD) 0.2 0.3 0.7 0.6 -0.8 0.1 -0.5 -0.5 -0.5 0.5 0.8 0.6 -0.4 0.0
Reaction Time 2.6 5.0 9.4 2.9 -3.0 1.8 -1.8 1.7 -2.1 -2.8 -0.4 -2.7 3.1 -0.2
Verbal and Numeric Reasoning (VNR) 1.5 3.5 10.4 0.1 2.0 0.8 1.8 1.3 2.1 -2.8 1.0 -1.5 3.2 1.9
Breast Cancer 0.7 1.6 3.7 -1.0 1.8 -0.9 1.9 -1.2 1.7 0.8 0.6 0.6 1.1 1.5
Ovarian Cancer 1.2 1.6 4.1 0.9 -0.3 -0.1 -0.6 1.7 -0.4 -1.8 -1.6 -2.0 -0.2 -1.9
Prostate Cancer 0.2 0.2 1.0 1.0 -0.5 -0.4 -0.5 0.1 -0.7 -0.3 0.2 0.2 0.5 -0.2
Age at First Birth 0.3 0.4 1.8 0.1 0.5 0.1 0.2 -1.0 0.3 0.6 1.3 0.8 0.4 -0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 4.0 0.6 -1.2 2.0 -0.9 0.4 -0.8 -0.4 -0.1 -0.8 0.3 0.1
Coronary Artery Disease (CAD) 1.4 1.7 3.1 1.4 -0.9 -1.0 -0.6 1.7 -0.7 -1.2 -1.7 -1.6 -1.1 -1.8
Crohns Disease (2012) 1.3 2.1 8.4 0.5 -1.5 -2.2 -0.9 1.7 -1.0 -0.3 -1.1 -0.4 -2.9 -1.3
Mean Putamen Volume 1.7 1.9 3.9 1.4 -1.3 0.8 -1.3 2.0 -1.2 -1.8 -1.5 -1.4 -0.7 -1.4
Fasting Glucose 0.5 0.6 4.6 -0.2 0.2 -0.4 0.1 -0.2 -0.1 0.6 0.5 0.1 -0.9 -2.1
HbA1C 0.7 0.8 3.5 -0.3 0.0 1.3 -0.2 -0.2 -0.1 -0.6 -0.2 -0.7 1.4 1.9
HDL Cholesterol 0.6 1.0 4.9 -0.3 0.0 -1.1 -0.0 -1.3 -0.1 1.1 0.9 1.2 0.3 2.2
LDL Cholesterol 0.1 0.2 0.8 0.3 -0.2 0.2 -0.2 0.3 -0.2 0.2 -0.5 -0.5 -0.9 -0.3
Lupus 0.6 1.0 1.9 -1.1 0.8 -1.3 1.4 -1.2 0.8 0.8 0.8 1.1 0.3 0.4
Neuroticism (2016) 0.9 1.3 2.7 -1.2 1.0 -1.6 0.9 -1.5 1.0 1.2 0.1 1.4 -0.2 1.3
Primary Biliary Cirrhosis 1.5 2.2 4.9 -1.8 2.1 -0.1 2.0 -0.8 2.2 0.7 1.3 1.1 0.8 1.5
Rheumatoid Arthritis 0.5 0.8 1.7 1.0 -0.8 1.2 -0.9 0.5 -0.9 -0.9 -0.6 -0.6 0.4 -1.3
Schizophrenia (2014) 0.3 0.6 4.1 -0.6 0.4 -2.0 -0.0 -0.5 -0.1 0.5 0.5 0.4 -0.7 -0.7
Triglycerides 0.4 0.6 1.4 0.9 -0.7 -0.0 -0.7 1.1 -0.6 -1.1 -0.8 -1.2 0.3 -0.5
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.5 0.1 -0.0 0.7 -0.1 0.3 0.1 -0.4 -0.7 -0.3 0.1 0.1
Ulcerative Colitis 0.7 1.0 3.2 -1.5 1.1 0.2 1.8 0.2 1.5 0.0 1.2 0.5 -0.1 0.6
Blood Eosinophil Count 0.9 7.3 14.4 -3.8 2.4 0.4 3.2 -2.4 3.4 2.8 2.9 3.0 1.0 2.7
Blood Platelet Count 0.6 7.0 17.2 -3.6 4.0 -1.0 4.2 -0.9 4.2 0.8 2.2 2.3 0.6 0.9
Blood Red Count 0.3 3.1 14.5 0.5 0.4 3.8 0.4 0.4 0.7 -1.8 0.9 -2.0 3.2 -0.7
Blood White Count 0.6 4.2 12.2 -1.9 2.3 0.2 3.5 -0.3 3.5 -0.4 2.4 0.7 2.1 1.6
Heel T-Score 0.2 1.6 4.3 1.5 -1.3 -0.5 -1.1 0.9 -1.1 -0.3 -1.9 -2.1 -0.9 -1.1
BMI 2.2 13.0 45.0 4.1 -4.4 6.7 -2.9 3.4 -2.6 -4.0 -1.7 -3.3 2.4 -0.1
Height 0.6 12.1 32.0 -0.5 -1.8 -4.0 -4.0 -3.5 -4.0 4.5 -0.8 2.4 -5.7 -3.3
Waist Hip Ratio (WHR) 0.1 0.6 2.4 -0.6 1.5 1.0 1.2 -0.2 0.9 -0.4 -0.3 -0.4 0.3 0.2
Systolic Blood Pressure 3.6 18.0 33.1 5.1 -4.7 2.1 -4.6 4.4 -4.3 -4.6 -4.6 -5.8 0.4 -3.2
Smoking Status 4.6 11.0 23.6 -4.0 3.1 -0.3 3.8 -3.1 3.8 1.9 3.4 3.1 2.8 4.9
Allergy or Eczema 0.1 0.2 0.6 -0.3 0.1 0.7 -0.3 -0.7 -0.2 0.7 -0.5 -0.0 0.1 0.5
Cardiovascular Disease 4.4 14.4 23.7 4.6 -4.9 2.6 -4.4 3.6 -4.0 -3.8 -4.3 -4.5 -0.6 -2.2
Hypothyroidism (self reported) 1.0 2.2 5.5 1.3 -1.0 2.1 -1.2 1.6 -0.8 -2.3 -0.7 -2.0 1.4 -0.8
Respiratory disease 1.5 3.3 6.0 -2.4 1.6 0.7 1.9 -2.1 1.9 1.7 2.3 1.8 1.3 1.7
Type 2 Diabetes (T2D) (2018) 1.1 2.0 5.3 1.8 -0.9 1.6 -0.1 2.2 -0.1 -2.3 -1.4 -1.6 1.1 0.2
Lung FEV1/FVC ratio 0.5 2.7 7.8 2.8 -1.6 1.2 -2.1 0.7 -2.0 -1.9 -0.9 -1.6 1.3 0.1
Lung FVC 4.4 22.1 35.5 5.4 -5.3 1.7 -6.0 4.4 -5.8 -3.1 -5.8 -4.2 -3.3 -4.8
Neuroticism 1.6 3.9 11.5 -2.8 0.8 -1.0 0.5 -3.4 0.4 2.9 1.5 2.7 0.5 1.8
Chronotype (morning person) 0.9 2.0 9.9 0.8 -0.7 -1.7 -0.8 0.7 -0.9 0.7 -2.2 0.3 -3.1 -0.9
Hair Pigment 0.2 5.6 10.8 -3.1 3.3 -0.4 2.7 -2.4 2.7 1.6 2.3 2.2 1.1 2.5
Tanning 0.0 0.4 1.4 1.0 -0.4 -0.2 -0.1 1.0 -0.3 -0.7 -0.1 -0.5 0.0 -1.2
Hand grip strength (left) 1.5 4.0 9.6 2.1 -2.5 -0.8 -3.1 -0.0 -3.1 0.8 -1.1 -0.1 -2.0 -2.8
Number of treatments/medications taken 1.7 3.0 5.1 1.9 -2.0 1.9 -1.3 1.6 -1.2 -2.3 -1.9 -2.2 1.4 0.9
Average weekly spirits intake 0.7 0.9 2.0 -0.5 1.0 0.8 1.4 0.8 1.3 -1.3 0.1 -1.2 0.6 0.6
Sensitivity / hurt feelings 1.2 2.1 5.1 -2.3 1.0 -1.1 0.7 -2.0 0.7 2.3 0.5 1.9 -1.2 0.8
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.8 -0.2 -0.1 -1.4 -0.9 -1.2 -0.8 0.8 -0.2 0.9 -0.2 1.0
Hearing difficulty/problems: Yes 0.1 0.2 0.7 0.5 -0.8 0.4 -0.5 0.5 -0.3 -0.3 0.2 0.3 -0.1 0.2
Relative age of first facial hair 5.3 10.8 19.3 -4.4 4.4 -3.6 4.0 -2.2 3.9 2.6 2.7 3.3 -0.0 2.4
Other serious medical condition/disability diagnosed by doctor 1.9 2.5 4.6 -2.1 1.6 0.7 1.6 -1.6 1.8 1.0 1.5 1.4 1.6 1.9
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.6 -0.7 -0.1 -0.3 -0.0 -0.7 0.0 0.2 0.7 0.1 0.8 0.7
Ever had hysterectomy (womb removed) 1.5 1.7 3.7 1.1 -1.2 0.8 -1.4 1.3 -1.4 -1.6 -1.1 -1.9 0.2 -1.6
Systolic blood pressure, automated reading 3.2 9.3 20.2 3.9 -4.5 1.7 -3.7 2.6 -3.7 -2.6 -2.5 -3.6 0.4 -1.9
Eye problems/disorders: Diabetes related eye disease 2.9 3.1 7.2 2.1 -0.8 1.7 -1.1 2.6 -0.8 -2.7 -1.7 -2.4 0.7 -1.4
Angina 1.6 2.2 4.6 -1.7 1.0 -1.0 2.0 -1.1 1.8 0.8 1.7 1.3 0.6 2.1
Medication for hormone replacement therapy 0.3 0.3 1.6 -0.2 0.7 -1.3 0.2 0.1 0.3 -0.4 -0.0 0.2 -0.4 1.0
Vitamin and mineral supplements 2.6 3.5 15.1 0.8 0.4 2.6 1.1 1.2 0.9 -2.8 1.3 -1.8 3.9 0.1
Supplements: Zinc 0.9 0.9 2.7 -0.9 0.9 -1.2 0.9 -0.2 1.0 1.1 -0.2 0.8 -1.6 -0.8
Medication: Co-codamol 2.7 3.1 6.4 -2.2 1.8 -0.9 2.5 -1.5 2.5 0.9 1.9 1.3 0.9 1.8
Medication: Metformin 1.3 1.8 5.7 1.4 -0.1 2.1 0.2 1.6 0.3 -2.4 -0.7 -1.3 1.7 0.7
Diabetes (father) 1.3 1.5 4.5 0.7 1.0 0.9 1.5 1.7 1.3 -2.1 -0.4 -1.5 1.0 -0.5
Diabetes (mother) 2.7 3.5 5.9 2.3 -1.8 1.8 -1.6 2.4 -1.4 -2.0 -2.4 -2.1 -0.3 -1.3
Severe depression (siblings) 0.3 0.4 1.7 0.2 0.4 1.0 0.1 -0.2 0.1 -0.5 -0.1 -0.6 1.3 0.8
Pack years adult smoking proportion 0.4 0.6 1.5 0.7 -0.9 0.9 -0.1 1.2 -0.1 -0.5 -1.0 -0.7 -0.7 -0.7
Impedance of leg (right) 1.4 7.0 17.1 -3.7 2.5 -2.5 1.2 -3.8 1.3 4.1 0.9 3.1 -1.8 1.5
Leg fat-free mass (left) 0.8 4.5 10.8 2.9 -3.3 1.4 -2.9 1.6 -3.0 -1.6 -0.4 -1.4 -0.2 -1.8
Trunk fat percentage 0.7 3.0 11.2 1.2 -1.9 3.4 -0.9 1.1 -0.9 -2.1 0.8 -1.2 2.4 1.1
Hand grip strength (right) 1.1 3.0 8.1 1.9 -2.0 -0.5 -2.9 -0.3 -2.8 1.0 -0.9 -0.0 -1.5 -2.2
Townsend deprivation index at recruitment 0.5 0.7 3.3 -0.4 0.7 -0.8 0.8 -0.6 0.8 0.5 0.6 0.9 0.2 1.8
Current tobacco smoking 2.1 3.5 10.5 -2.0 2.1 0.1 1.9 -1.8 2.0 0.9 1.3 1.9 1.5 3.2
Average weekly fortified wine intake 2.7 3.1 4.4 -2.1 1.7 -0.1 1.8 -2.1 1.7 1.9 2.0 2.0 1.0 1.9
Maternal smoking around birth 0.4 0.6 2.8 0.8 -0.6 -0.4 0.0 1.0 0.0 -0.6 0.1 -0.6 -0.9 -1.7
Fed-up feelings 0.9 1.7 5.2 -1.1 0.1 -1.3 -0.7 -2.3 -0.5 2.0 0.2 1.8 -0.8 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 4.5 -1.3 0.7 -1.3 0.5 -1.9 0.6 1.9 0.3 2.1 -0.8 1.2
Relative age voice broke 0.5 0.7 1.9 -1.0 1.4 -1.4 0.8 -0.5 0.7 0.8 0.2 0.8 -0.6 -0.1
Taking other prescription medications 0.5 0.8 2.6 -0.4 -0.9 1.6 -0.2 -0.9 0.0 0.4 0.1 0.2 1.3 1.5
Age when periods started (menarche) 1.0 2.3 10.8 0.1 -0.1 -1.7 -1.3 -0.2 -1.4 1.4 -1.5 0.4 -3.3 -2.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.5 0.4 0.5 -0.0 0.1 0.9 0.1 -1.2 -0.8 -0.9 0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 3.2 0.8 -1.1 -1.1 -0.8 1.1 -0.9 -0.4 -1.4 -1.8 -0.8 -0.8
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 3.1 -1.8 0.8 -0.2 0.6 -1.5 0.4 1.4 0.7 1.1 -0.2 0.8
Qualifications: CSEs or equivalent 1.0 1.4 3.1 0.7 -0.6 -0.9 -1.0 1.4 -1.1 -0.7 -1.4 -0.7 -1.7 -1.8
Serious illness, injury or assault to yourself 1.4 1.6 4.1 1.3 -1.3 1.0 -1.0 2.0 -0.9 -1.2 -2.0 -1.2 -0.9 0.0
High blood pressure 3.9 10.9 18.8 3.8 -4.3 2.6 -3.5 3.4 -3.5 -3.4 -3.9 -3.9 0.1 -0.9
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.8 -0.7 0.5 0.1 0.1 -0.8 0.1 0.9 0.1 0.7 -0.1 0.3
Multivitamins +/- minerals 1.9 2.4 10.6 0.6 -1.1 -1.8 -1.8 0.4 -1.6 0.9 -2.0 0.4 -3.2 -0.6
Stomach or abdominal pain in last month 0.3 0.3 1.1 -1.0 0.6 -0.1 0.7 -0.7 0.6 0.3 -0.0 0.5 0.3 0.6
Supplements: Glucosamine 2.1 2.8 5.2 2.3 -2.0 0.7 -1.5 2.0 -1.7 -2.0 -1.8 -2.1 0.2 0.0
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 3.1 0.8 -0.7 0.3 -1.0 -0.9 -1.2 -0.2 -0.5 -0.3 1.8 0.4
Medication: Atenolol 0.6 0.8 2.7 1.1 -1.7 0.4 -0.7 1.0 -0.6 -0.8 -0.6 -1.0 -0.7 -0.4
Medication: Levothyroxine sodium 1.4 2.3 7.1 1.2 -1.3 2.7 -1.2 0.6 -1.0 -2.1 -0.1 -1.6 2.4 0.2
Sitting height 1.4 9.9 24.2 1.7 -4.1 -1.1 -4.9 -1.1 -4.7 2.2 -1.8 0.1 -4.4 -3.5
Chronic bronchitis/emphysema (father) 0.5 0.6 2.1 1.0 -1.1 0.5 -0.4 0.6 -0.8 -0.4 -0.8 -0.7 -0.5 -1.5
High blood pressure (mother) 0.7 1.0 2.0 1.1 -1.4 1.4 -0.9 0.7 -0.8 -1.0 -1.1 -1.2 0.1 -0.7
Body mass index (BMI) 1.4 5.8 18.4 2.7 -3.0 4.3 -1.4 2.3 -1.4 -3.0 0.3 -2.0 2.6 0.5
Impedance of leg (left) 1.8 8.6 20.2 -3.9 2.6 -3.1 1.4 -4.1 1.5 4.5 0.9 3.6 -2.2 1.8
Leg predicted mass (left) 0.9 4.6 11.2 2.9 -3.3 1.4 -3.0 1.6 -3.1 -1.6 -0.5 -1.5 -0.1 -1.8
Trunk fat mass 0.8 3.2 10.2 1.8 -2.7 3.2 -1.8 1.1 -1.8 -1.8 0.5 -1.1 1.5 0.4
Waist circumference 1.2 4.4 18.1 2.0 -2.3 4.3 -1.2 1.5 -1.2 -2.5 0.2 -1.8 2.5 0.6
Number of incorrect matches in round 1.1 1.8 5.8 0.6 -2.4 1.0 -1.9 -0.8 -2.0 0.5 -1.2 -0.8 1.2 1.1
Past tobacco smoking 2.1 3.9 8.2 1.7 -2.1 -0.7 -2.7 0.8 -2.6 0.3 -2.2 -0.7 -2.8 -2.9
Alcohol usually taken with meals 0.2 0.4 1.6 1.0 -1.2 0.4 -0.5 -0.0 -1.0 0.1 -0.3 0.2 0.4 0.1
Nervous feelings 1.2 2.3 7.0 -2.1 0.9 -0.6 0.6 -2.6 0.4 2.1 1.4 1.9 0.9 1.3
Frequency of tenseness / restlessness in last 2 weeks 1.9 2.9 10.0 -1.6 0.1 -1.1 -0.7 -2.8 -0.8 3.2 0.5 2.7 -1.1 0.8
Hearing difficulty/problems with background noise 0.5 0.7 1.4 0.9 -1.2 0.5 -1.1 0.7 -0.9 -0.8 -0.5 -1.0 0.1 -1.0
Hair/balding pattern: Pattern 2 0.5 0.6 2.7 0.2 1.3 -1.6 0.6 0.5 0.6 -0.9 0.3 0.1 0.0 0.7
Had menopause 1.0 1.2 5.4 -0.2 -0.9 1.4 -0.6 -1.1 -0.7 -0.1 1.0 -0.5 2.3 1.4
Had other major operations 0.5 0.6 1.5 -0.5 -1.1 0.2 -0.7 -1.0 -0.9 1.2 -0.6 0.6 -0.1 1.0
Forced vital capacity (FVC) 2.7 10.3 22.6 2.8 -3.1 -0.1 -4.6 1.3 -4.4 -0.1 -3.8 -1.6 -3.8 -4.8
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 6.2 1.7 -2.0 -0.6 -1.7 1.6 -1.8 -0.8 -1.8 -2.5 -0.6 -0.9
Ever unenthusiastic/disinterested for a whole week 0.5 0.7 2.0 -0.9 -0.1 -0.6 -0.1 -1.0 -0.1 1.4 0.1 1.3 -1.1 0.4
Qualifications: None of the above 0.9 2.0 8.0 -0.9 -0.6 1.1 -0.1 -1.6 -0.2 1.9 0.4 2.2 0.3 2.8
Financial difficulties in last 2 years 0.4 0.5 1.2 0.0 -0.5 -0.8 -0.7 -0.9 -0.6 0.9 0.1 1.1 -0.9 0.7
Mouth/teeth dental problems 0.6 1.0 2.1 0.9 -1.4 -0.4 -1.1 -1.1 -1.0 0.5 1.3 0.6 1.3 0.7
Heart attack 2.0 2.6 5.0 -2.1 1.7 -0.5 2.2 -1.3 2.2 1.2 1.2 2.1 0.0 1.7
Allergy 0.2 0.5 1.2 1.1 -0.9 -0.3 -0.8 0.7 -0.8 -0.6 -0.5 -0.7 -0.2 -0.8
Pain all over the body in last month 1.1 1.2 4.7 0.9 -0.8 0.8 -0.8 0.8 -0.8 0.4 -0.7 0.1 -2.2 -2.0
Diabetes (self-reported) 1.7 2.7 7.4 1.8 -0.6 2.0 -0.0 2.5 0.1 -2.7 -1.7 -2.0 1.2 0.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.5 -0.1 0.4 -0.6 0.1 -0.4 -0.1 0.3 0.1 0.4 0.3 0.7
Medication: Ramipril 0.4 0.5 2.0 -0.3 0.8 -0.5 0.3 -0.9 0.5 0.9 -0.5 0.8 -0.4 1.4
Medication: Simvastatin 1.0 1.5 2.5 1.3 -1.3 1.4 -0.9 1.1 -0.8 -1.4 -1.5 -1.6 0.8 0.9
Fluid intelligence score 1.5 3.1 11.5 1.3 0.7 -0.1 0.9 2.8 1.1 -3.4 -0.1 -2.6 1.8 0.2
Illnesses of siblings 1.8 2.5 4.3 -1.7 2.1 -1.7 1.6 -1.4 1.6 2.0 1.0 2.0 -1.0 0.6
Neuroticism score 1.4 3.0 7.5 -2.7 1.4 -1.1 0.7 -2.7 0.8 2.3 1.0 2.3 0.3 1.6
Weight 0.7 3.6 10.6 2.2 -3.2 2.8 -2.5 0.9 -2.5 -1.3 0.2 -0.9 0.8 -0.4
Impedance of arm (right) 0.6 2.8 10.1 -2.5 3.2 -1.3 1.9 -1.2 1.9 0.9 0.8 1.3 -0.1 1.1
Arm fat percentage (right) 1.2 4.6 18.1 1.5 -1.5 4.3 -0.2 1.9 -0.2 -3.0 1.1 -1.6 3.1 1.2
Trunk fat-free mass 0.8 4.5 12.1 2.2 -3.5 0.2 -3.5 0.1 -3.5 0.5 -0.7 0.0 -2.1 -1.9
Hip circumference 1.4 6.0 17.1 2.5 -3.4 4.1 -2.3 1.7 -2.2 -2.6 0.5 -1.9 2.6 -0.2
Time employed in main current job 0.3 0.4 1.0 -0.7 0.6 -1.0 0.7 -0.4 0.6 0.9 0.6 0.5 -0.4 -0.1
Alcohol intake versus 10 years previously 1.2 1.8 4.8 1.7 -2.2 1.5 -2.0 0.1 -1.9 -0.4 -0.7 -0.3 0.5 1.1
Father’s age at death 0.5 0.7 1.4 -1.2 0.8 -0.8 0.8 -0.7 0.6 0.7 0.3 0.7 -1.0 -1.0
Worrier / anxious feelings 1.0 1.9 4.5 -2.1 1.2 -0.9 0.8 -2.1 0.4 1.4 0.5 1.3 1.1 1.9
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 2.7 -0.3 0.1 -0.4 -0.3 -0.1 0.1 0.5 -0.9 0.6 -1.6 -0.7
Falls in the last year 0.7 0.9 3.4 -0.2 -0.7 1.5 -0.1 -0.8 0.0 0.1 1.8 -0.0 1.4 1.2
Hair/balding pattern: Pattern 3 1.0 1.5 6.9 -0.3 -0.0 2.4 0.4 0.0 0.4 -0.7 1.6 -0.4 2.6 0.2
Number of live births 0.4 0.6 1.4 0.4 -0.7 -1.2 -0.8 -1.0 -1.0 0.9 0.3 1.1 -0.4 0.1
Forced expiratory volume in 1-second (FEV1) 3.2 10.9 24.1 3.5 -3.3 0.8 -4.9 1.6 -4.7 -0.8 -3.6 -2.1 -2.8 -4.7
Pulse rate 1.5 2.5 11.5 0.9 -0.7 3.4 -0.4 1.2 -0.2 -1.8 -0.1 -1.8 2.5 -0.3
Happiness 1.3 1.6 5.1 -0.8 0.3 -2.3 0.5 -1.7 0.3 1.8 0.1 1.7 -1.4 0.4
Noisy workplace 1.7 2.1 12.5 -0.4 -0.1 -1.4 0.3 -0.2 0.2 1.8 -0.9 1.7 -3.5 -1.3
Qualifications: A levels/AS levels or equivalent 0.5 1.0 3.6 0.6 0.8 -0.0 0.8 0.8 0.8 -1.6 0.9 -1.2 1.9 0.1
Serious illness, injury or assault of a close relative in last 2 years 2.3 2.7 8.1 1.6 -0.2 1.4 -0.2 1.9 -0.2 -2.9 -0.2 -2.8 1.7 -1.5
Mouth/teeth dental problems: Dentures 0.4 0.7 1.9 -0.3 -0.1 -0.7 0.4 1.4 0.5 -1.2 -1.2 -1.0 -0.7 -0.8
Asthma 2.2 4.3 6.3 -2.5 1.9 0.0 2.5 -2.2 2.5 1.8 2.3 2.2 1.2 2.3
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.6 1.9 0.9 -1.0 0.8 -0.8 -0.2 -0.7 -0.2 -0.2 -0.2 0.8 1.4
Medication: Cholesterol lowering 1.5 2.3 5.2 1.5 -1.5 2.3 -0.9 1.9 -0.8 -1.9 -1.9 -1.8 0.1 0.4
Depression (self-reported) 0.4 0.4 2.2 0.0 0.1 1.5 -0.3 -0.2 -0.2 -0.3 0.2 -0.4 1.2 1.0
Medication: Lansoprazole 0.2 0.2 0.5 -0.7 0.7 -0.4 0.5 -0.2 0.5 -0.5 -0.4 -0.0 0.1 0.3
Prospective memory result 1.0 1.3 3.7 -1.2 1.1 -0.2 0.7 -1.2 0.6 1.8 0.3 1.9 -1.4 0.5
Lung cancer (father) 4.5 5.2 9.9 3.1 -2.8 1.5 -2.4 2.2 -2.6 -2.1 -2.4 -2.6 -0.1 -1.6
Illnesses of mother 1.4 1.7 4.5 -1.2 2.1 -0.5 1.3 -1.3 1.2 0.8 1.8 1.2 1.1 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.4 7.6 16.5 2.8 -2.7 0.3 -4.1 1.3 -3.9 -0.6 -3.3 -1.7 -2.5 -3.8
Pulse wave Arterial Stiffness index 0.8 0.9 2.8 -1.0 0.2 -0.1 1.2 -0.4 1.2 0.0 1.7 0.5 1.2 1.2
Impedance of arm (left) 0.4 1.9 8.2 -2.1 2.9 -0.7 1.5 -0.9 1.6 0.0 0.8 0.6 0.8 0.8
Arm fat mass (right) 1.0 4.3 15.7 2.0 -2.6 4.0 -1.4 1.6 -1.4 -2.5 0.6 -1.6 2.3 0.4
Trunk predicted mass 0.8 4.5 12.0 2.3 -3.5 0.2 -3.4 0.1 -3.5 0.5 -0.7 -0.0 -2.1 -1.9
Standing height 0.6 6.0 13.9 -0.7 -1.0 -2.7 -2.8 -2.7 -2.8 3.4 -0.0 2.1 -3.7 -2.1
Length of working week for main job 0.4 0.5 1.3 -0.1 0.9 0.4 0.7 1.1 0.6 -1.1 0.6 -0.4 0.7 -0.0
Exposure to tobacco smoke at home 2.3 2.6 5.8 1.8 -2.2 0.3 -2.4 1.3 -2.1 -0.7 -2.1 -1.1 -1.2 -0.8
Breastfed as a baby 0.4 0.5 1.7 0.5 -1.1 0.0 -1.3 -0.1 -1.2 0.3 -0.7 -0.1 -0.3 0.5
Tense / ‘highly strung’ 2.5 4.1 8.0 -2.8 1.8 -0.6 1.0 -2.8 1.1 2.5 1.7 2.7 1.0 2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 3.7 0.5 -1.6 0.2 -1.7 -1.5 -1.9 1.0 -0.4 0.5 0.5 0.6
Hair/balding pattern: Pattern 4 0.4 0.9 2.8 0.3 -1.7 0.4 -1.5 -0.4 -1.6 0.8 -0.6 0.1 -0.8 -0.4
Birth weight of first child 1.2 2.1 8.1 -0.5 1.3 0.1 1.0 0.0 1.1 -1.4 2.8 -0.7 2.9 0.8
Peak expiratory flow (PEF) 1.2 2.9 7.7 2.2 -1.8 1.1 -2.8 0.6 -2.5 -0.6 -1.2 -1.0 -0.6 -2.2
Pulse wave reflection index 1.8 2.2 5.2 -1.6 0.8 -2.3 1.5 -1.2 1.3 1.4 2.0 1.7 -0.6 1.3
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.3 -0.0 -0.7 0.4 -0.8 -1.0 -0.9 1.5 0.4 1.3 -1.1 0.2
Loud music exposure frequency 3.3 3.7 10.7 -2.1 1.0 -0.8 0.7 -2.6 0.9 3.3 0.9 3.3 -1.9 0.7
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 6.1 0.1 1.2 1.2 1.0 0.1 1.0 -0.9 1.6 -0.8 2.5 -0.1
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.1 -0.0 1.1 0.9 0.7 1.3 0.7 -1.0 -0.8 -1.5 -0.6 -0.5
Blood clot in the leg (DVT) 0.5 0.7 2.0 -0.4 0.7 1.4 0.9 -0.3 0.9 -0.5 0.8 0.1 1.4 0.6
Medication: Paracetamol 0.5 0.9 4.0 0.3 -0.5 0.4 -0.3 -0.2 -0.4 -0.8 -0.4 -0.5 1.9 2.0
Headache pain in last month 0.3 0.5 1.9 -1.4 0.0 -0.4 0.2 -1.1 0.4 1.2 0.2 0.4 -0.0 0.6
Medication for cholesterol, blood pressure or diabetes 2.9 4.8 8.4 -2.8 2.6 -1.7 1.7 -2.8 1.7 2.6 2.9 2.6 0.1 -0.2
Glaucoma (self-reported) 1.5 1.7 4.8 -2.2 1.1 -0.1 1.0 -1.7 0.9 1.7 0.5 1.2 0.2 1.9
Gout (self-reported) 0.9 1.2 5.7 0.5 -0.1 1.0 -0.6 -0.4 -0.4 -0.7 1.6 -0.5 2.4 1.5
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 5.1 1.0 -1.0 2.3 -1.2 1.1 -0.9 -2.1 -0.3 -1.8 2.1 0.0
Medication: Amlodipine 1.3 1.8 6.2 2.2 -0.9 -0.5 -0.0 2.4 -0.2 -2.5 0.0 -1.4 0.3 -0.2
Medication: Ventolin 100micrograms inhaler 0.8 1.0 1.7 -1.2 1.1 0.9 1.3 -1.0 1.1 0.8 1.2 1.0 0.2 -0.4
Birth weight 0.4 0.8 2.6 -1.0 0.4 -0.3 0.5 -1.2 0.4 0.7 1.0 0.9 0.8 1.6
Chronic bronchitis/emphysema (mother) 1.3 1.5 3.4 0.7 -1.5 -1.1 -1.5 -0.7 -1.3 1.4 -0.8 0.7 -1.8 -1.3
High blood pressure (siblings) 2.8 4.1 6.6 2.1 -2.4 2.3 -2.2 2.0 -2.1 -2.5 -1.5 -2.6 0.8 -0.9
Forced vital capacity (FVC), Best measure 2.4 8.8 17.2 2.6 -2.9 -0.4 -4.1 1.1 -4.0 0.2 -3.8 -1.3 -3.7 -4.1
Body fat percentage 0.7 2.9 12.0 1.2 -2.0 3.5 -0.8 1.0 -0.8 -1.9 0.9 -1.0 2.4 1.2
Leg fat percentage (right) 0.6 2.1 8.8 1.1 -2.1 3.0 -0.9 0.6 -0.8 -1.2 0.7 -0.7 1.7 1.2
Arm fat-free mass (right) 1.0 5.1 15.2 2.5 -3.9 0.5 -3.7 0.3 -3.7 0.2 -0.6 -0.4 -1.5 -1.8
Exposure to tobacco smoke outside home 0.5 0.7 2.4 0.1 0.2 -0.0 -0.5 1.0 -0.4 -0.5 -1.6 -0.9 -1.3 -0.9
Comparative body size at age 10 2.8 7.9 18.6 3.5 -1.9 0.2 -1.4 4.3 -1.5 -2.7 -3.7 -3.0 -2.5 -3.4
Number of full brothers 3.8 4.8 7.3 2.6 -2.6 2.7 -2.5 1.9 -2.2 -2.1 -2.5 -2.3 0.7 -1.1
Worry too long after embarrassment 0.3 0.4 1.6 -0.3 -0.4 0.0 -0.4 0.5 -0.3 -0.1 -1.2 -0.7 -0.7 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 3.5 0.9 -0.2 1.6 -0.6 -0.1 -0.7 -1.0 0.6 -0.6 1.9 1.3
Wheeze or whistling in the chest in last year 0.6 1.1 3.9 -1.2 0.8 -0.4 1.1 0.0 1.0 1.2 0.2 1.6 -2.0 0.1
Number of children fathered 1.1 1.3 3.6 -0.7 0.2 -1.5 0.6 -1.1 0.7 1.9 0.3 1.9 -1.1 0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 6.7 1.0 -1.5 2.6 -1.8 -0.6 -1.8 -0.3 -0.2 -0.8 1.7 0.3
Age at first live birth 0.8 1.3 4.1 -0.9 1.3 -0.2 1.3 -1.1 1.4 1.3 2.0 1.1 0.6 -0.5
Pulse wave peak to peak time 0.8 0.9 2.3 0.9 -0.2 -0.2 -1.3 0.1 -1.3 0.2 -1.5 -0.3 -1.3 -1.3
Health satisfaction 0.8 1.1 3.2 -0.9 0.2 -0.6 0.1 -1.4 0.1 1.8 -0.4 1.6 -1.5 -0.3
Shortness of breath walking on level ground 0.3 0.3 1.5 0.5 -0.2 1.2 -0.6 -0.1 -0.5 -0.6 0.6 0.2 0.4 0.3
Qualifications: College or University degree 0.4 1.3 3.9 1.0 0.7 0.9 0.3 1.7 0.5 -2.0 -0.3 -1.8 1.5 0.2
Eye problems/disorders: None of the above 0.2 0.2 1.0 -0.2 -0.1 -0.2 -0.2 -0.8 -0.3 0.6 1.0 0.3 -0.0 -0.2
Mouth/teeth dental problems: Loose teeth 0.7 0.8 3.0 0.8 -0.7 1.7 -1.0 0.2 -0.9 -0.7 0.4 -0.3 1.3 0.9
Emphysema/chronic bronchitis 1.0 1.1 2.4 -1.4 -0.2 -1.3 -0.3 -0.9 -0.5 1.6 -0.1 1.6 -1.6 0.2
Medication for pain relief, constipation, heartburn 0.3 0.5 2.6 -0.2 0.9 -0.6 0.3 -0.0 0.2 0.1 0.9 0.0 -0.4 -1.6
Neck or shoulder pain in last month 0.7 0.9 3.1 -0.9 0.3 -0.1 0.2 -1.4 0.5 1.2 0.9 1.8 -0.7 1.2
Medication: Blood pressure 2.7 4.8 8.6 2.9 -2.8 1.3 -2.4 2.1 -2.3 -2.4 -2.5 -2.6 0.3 0.7
Angina (self-reported) 2.2 2.9 6.6 -2.0 1.2 -1.0 2.2 -1.4 2.0 1.1 2.0 1.6 0.8 2.6
Migraine (self-reported) 0.9 1.1 3.4 0.8 -0.8 1.8 -1.2 0.5 -0.9 -0.9 -1.4 -1.4 0.6 -0.5
Medication: Ibuprofen 0.9 1.0 3.0 1.7 -1.4 0.6 -1.4 -0.1 -1.3 -0.4 -0.6 -0.4 0.5 1.1
Medication: Allopurinol 0.4 0.6 3.2 0.2 -0.0 0.3 -0.2 -0.4 0.0 -0.5 0.6 -0.4 1.8 1.3
Medication: Omeprazole 0.5 0.6 1.6 0.7 -1.3 0.8 -1.0 -0.8 -1.1 0.7 0.3 0.4 0.3 0.6
Medication: Seretide 50 evohaler 1.2 1.3 2.9 -1.2 0.9 1.2 1.6 -0.6 1.4 0.3 1.7 0.9 1.1 1.0
Mean time to correctly identify matches 1.9 3.6 13.0 2.1 -1.9 2.2 -0.8 0.9 -1.0 -2.5 0.4 -2.0 3.6 0.8
Heart disease (mother) 0.5 0.6 2.1 -0.5 0.2 0.0 0.9 1.1 0.7 -0.6 -0.4 -0.5 -0.9 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 2.2 -0.6 0.2 0.6 0.1 -1.5 0.2 1.0 0.5 0.5 0.4 0.5
Whole body fat mass 0.8 3.5 10.8 2.0 -2.9 3.3 -1.9 1.2 -1.9 -1.8 0.4 -1.2 1.5 0.3
Leg fat mass (right) 0.9 3.6 10.7 2.2 -3.0 3.3 -1.9 1.2 -1.9 -1.8 0.2 -1.2 1.4 0.2
Arm predicted mass (right) 0.8 4.2 13.3 2.3 -3.6 0.8 -3.4 0.1 -3.5 0.2 -0.4 -0.5 -1.0 -1.5
Pulse rate, automated reading 1.7 5.6 14.9 2.8 -1.4 3.4 -0.7 2.7 -0.6 -3.9 -0.4 -2.9 2.8 -1.0
Alcohol intake frequency. 0.8 1.9 4.9 2.0 -2.2 -0.6 -1.3 0.8 -1.4 -0.2 -1.7 -0.2 -1.4 -1.7
Comparative height size at age 10 0.1 0.8 2.6 -0.6 -0.5 1.6 -1.3 -1.1 -1.1 0.5 0.6 0.7 0.5 0.6
Number of full sisters 0.8 0.9 2.7 1.6 -1.3 0.8 -1.0 0.6 -0.9 -1.1 -0.6 -0.6 0.7 0.6
Suffer from ‘nerves’ 1.2 1.9 5.1 -1.9 0.4 0.1 0.3 -2.1 0.2 2.3 0.6 1.8 -0.2 1.9
Overall health rating 0.2 0.5 1.9 0.2 -0.8 1.4 -0.6 0.3 -0.5 -0.4 -0.7 0.1 -0.9 -1.0
Chest pain or discomfort 0.7 1.0 3.2 -0.3 -0.1 -0.7 -0.0 1.7 -0.0 -0.4 -1.5 -0.4 -1.8 -1.1
Had major operations 0.3 0.3 1.1 -0.3 0.4 1.0 0.6 0.3 0.6 -0.0 0.2 0.6 -0.6 0.6
Age at last live birth 2.3 3.4 6.1 -1.8 1.9 -0.5 1.6 -2.2 1.8 2.1 2.5 2.4 0.7 1.6
Family relationship satisfaction 0.3 0.4 1.6 -0.5 0.1 -0.5 0.2 -1.3 0.2 0.7 0.6 0.6 0.6 -0.2
Leg pain on walking 0.6 0.8 1.3 0.8 -0.5 1.1 -0.8 1.1 -0.6 -1.1 -0.8 -1.0 -0.6 -1.0
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.9 5.3 0.7 -1.0 -1.4 -0.9 1.1 -0.9 -0.1 -1.7 -1.3 -2.1 -2.3
Commuting to job workplace: Car/motor vehicle 0.9 1.0 3.0 0.7 -0.7 0.1 -0.6 1.6 -0.8 -0.2 -1.0 -0.4 -1.7 -1.5
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.1 -1.3 1.4 -1.2 1.4 -0.5 1.3 0.6 1.4 1.1 -0.0 -0.4
Medication: Aspirin 0.4 0.5 1.7 -0.9 0.6 -0.1 1.2 0.7 1.3 -0.4 -0.4 0.1 -0.3 0.5
Supplements: Vitamin C 2.8 3.3 8.7 -2.0 1.4 -2.1 1.2 -2.1 1.1 2.9 0.7 2.5 -1.5 1.1
Knee pain experienced in last month 1.2 1.9 9.3 0.2 -0.8 2.4 -0.1 -0.3 -0.2 -0.6 1.1 -0.4 3.0 1.7
Hypertension (Self-reported) 4.3 11.8 21.4 4.0 -4.6 2.5 -3.9 3.4 -3.8 -3.5 -4.1 -4.0 0.1 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.9 -0.4 0.2 -0.3 -0.0 -0.9 0.1 0.5 0.1 0.6 -0.1 0.2
Illnesses of father: Heart disease 0.1 0.1 0.5 0.3 -0.2 -0.3 0.0 0.3 0.2 -0.5 0.1 -0.6 -0.2 -0.7
Illnesses of siblings: Diabetes 1.5 1.8 4.3 1.2 -0.8 2.1 -0.5 1.8 -0.3 -2.1 -0.7 -1.9 0.7 -1.0
Smoking status: Previous 1.2 1.7 3.4 -1.3 1.1 1.0 1.8 -0.5 1.6 -0.0 1.7 0.7 1.6 1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 4.5 -1.1 -0.3 -0.5 -1.2 -2.1 -0.9 1.7 1.1 1.6 -0.1 0.9
Whole body fat-free mass 0.7 4.2 11.8 2.5 -3.4 0.6 -3.3 0.6 -3.3 -0.3 -0.5 -0.6 -1.3 -1.9
Leg fat-free mass (right) 0.7 3.9 9.2 2.8 -3.0 1.0 -2.7 1.5 -2.8 -1.6 -0.5 -1.3 -0.3 -1.8
Arm fat percentage (left) 1.4 5.7 19.7 2.0 -1.9 4.4 -0.6 2.3 -0.6 -3.5 0.8 -2.0 3.4 0.9
Average weekly red wine intake 1.1 1.7 7.7 0.9 -0.1 1.6 -0.3 0.9 -0.3 -1.7 -0.3 -1.8 2.8 0.6
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.7 0.6 -0.3 -1.5 -0.8 0.7 -1.0 0.1 -0.9 0.4 -1.6 -1.1
Mood swings 1.0 1.8 5.4 -1.3 0.3 0.4 -0.3 -2.3 -0.3 1.3 1.4 1.6 1.5 1.8
Loneliness, isolation 4.1 5.7 14.5 -2.8 2.2 -1.7 1.6 -3.8 1.5 2.9 2.3 3.0 0.6 2.1
Long-standing illness, disability or infirmity 1.9 2.8 12.5 -0.2 0.4 3.5 1.2 1.3 1.3 -2.3 0.0 -1.1 2.6 0.9
Ever had bowel cancer screening 1.9 2.2 4.1 -2.0 1.1 0.8 1.7 -1.6 1.5 1.7 1.9 1.8 0.6 0.7
Diabetes diagnosed by doctor 1.6 2.6 7.2 1.9 -0.9 1.9 -0.0 2.5 0.0 -2.7 -1.5 -2.0 0.8 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 0.4 -0.5 0.2 -0.9 -0.6 -1.0 0.1 -0.0 0.3 0.4 0.5
Friendships satisfaction 0.5 0.6 1.8 -0.9 1.0 -1.4 0.6 -0.9 0.6 0.7 -0.1 0.1 -0.5 -0.7
Qualifications: nursing, teaching 0.5 0.8 3.3 0.3 1.0 -1.8 1.0 0.8 0.9 -1.0 0.5 -0.4 0.5 -0.8
Commuting to job workplace: Walk 1.1 1.2 2.6 1.6 -0.6 -1.0 -1.1 1.3 -1.0 -1.4 -0.8 -1.6 -0.3 -0.4
Eye problems/disorders: Cataract 1.1 1.3 2.8 1.2 -1.1 1.7 -1.1 1.3 -1.0 -1.0 -1.7 -1.0 -0.4 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.6 -0.8 1.3 0.3 0.7 0.1 1.0 0.2 0.2 0.5 0.2 0.7
Medication for cholesterol 0.2 0.3 1.4 0.1 0.0 0.2 0.1 -0.4 -0.1 1.0 0.6 1.2 -0.5 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.9 3.4 10.7 -1.7 1.5 -3.0 1.4 -0.2 1.6 1.9 -0.6 1.8 -3.3 -1.0
Back pain experienced in last month 0.8 1.2 3.1 -0.4 -1.0 1.0 -1.2 -1.8 -1.4 1.4 0.4 1.2 0.0 1.2
Mineral and other dietary supplements 0.3 0.4 1.5 -0.2 -0.5 0.0 -0.3 -0.4 -0.2 0.2 0.7 0.6 0.9 1.2
Breast cancer (self-reported) 0.8 0.9 5.8 0.4 -1.2 2.4 -1.1 -0.1 -1.0 0.1 -0.7 -0.1 -0.2 -0.1
Asthma (self-reported) 1.7 3.3 5.2 -2.3 1.8 0.0 2.2 -1.9 2.1 1.6 2.1 1.9 1.1 1.9
Osteoporosis (self-reported) 0.7 0.8 2.6 -1.1 0.7 -0.5 0.8 -0.9 0.5 1.6 0.8 1.2 -1.0 -0.1
Osteoarthritis (self-reported) 0.7 0.9 3.1 -0.1 0.1 1.5 1.2 0.7 0.9 -1.0 0.7 -0.8 1.8 0.3
Medication: Aspirin 0.3 0.4 1.5 -0.2 -0.0 -0.2 0.4 1.2 0.5 -0.6 -1.2 -0.4 -0.9 -0.1
Medication: Gliclazide 0.2 0.2 0.9 0.4 0.2 0.0 0.3 0.8 0.5 -0.4 0.2 -0.2 -0.2 -0.9
Illnesses of father: None of the above (group 1) 0.5 0.6 1.7 -1.0 0.9 0.5 0.3 -1.0 0.2 1.3 0.7 0.8 0.2 1.0
Smoking status: Current 3.3 5.3 14.1 -2.6 2.4 -0.1 2.3 -2.4 2.4 1.4 1.9 2.4 1.9 3.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.7 5.6 11.2 2.7 -3.0 1.0 -3.2 1.2 -3.3 -0.8 -2.4 -2.0 -1.1 -3.0
Whole body water mass 0.8 4.4 12.1 2.6 -3.5 0.7 -3.3 0.7 -3.4 -0.4 -0.6 -0.7 -1.2 -1.9
Leg predicted mass (right) 0.8 4.2 10.0 2.9 -3.2 1.0 -2.9 1.6 -2.9 -1.6 -0.5 -1.4 -0.3 -1.8
Arm fat mass (left) 1.3 5.4 16.6 2.5 -2.7 4.1 -1.7 2.0 -1.6 -3.0 0.4 -2.1 2.5 0.2
Number of self-reported non-cancer illnesses 2.1 3.6 12.1 1.0 -1.1 3.5 -0.4 1.6 -0.2 -2.8 -0.7 -2.2 2.7 1.2
Average weekly champagne plus white wine intake 1.6 2.2 6.2 -1.7 0.5 -2.5 0.5 -1.5 0.5 1.9 0.6 1.8 -1.1 1.8
Miserableness 1.1 1.9 5.6 -1.5 1.4 -0.4 0.4 -2.0 0.4 1.5 0.9 1.8 0.8 2.4
Guilty feelings 0.5 0.8 2.7 -1.1 0.4 -0.2 0.5 -1.3 0.3 0.6 1.1 0.6 1.6 1.0
Wears glasses or contact lenses 0.3 0.3 1.4 -0.1 -0.3 -0.9 -0.1 -0.7 0.0 0.1 0.1 -0.1 0.9 1.2
Ever taken oral contraceptive pill 1.6 1.8 5.3 -1.6 2.3 0.2 1.9 -0.0 2.1 -0.2 1.4 0.5 1.2 0.8
Hearing aid user 0.9 1.0 2.9 -1.4 0.9 -0.6 1.0 -0.6 0.8 0.8 0.7 1.4 -0.2 1.7
Mother’s age at death 0.7 0.9 2.7 -0.9 0.5 -1.6 1.0 -0.6 1.0 0.8 0.7 1.0 -0.9 -0.8
Financial situation satisfaction 2.1 2.7 6.8 -1.6 1.1 -2.5 0.8 -1.5 0.7 2.1 1.3 2.6 -1.5 0.8
Tinnitus: Yes, now most or all of the time 1.0 1.2 3.2 -0.0 -1.7 1.8 -1.5 -0.7 -1.4 1.0 -1.0 0.1 -0.3 -0.5
Commuting to job workplace: Public transport 2.9 3.4 6.3 -2.2 2.0 -1.3 2.0 -1.5 2.3 0.6 2.1 1.0 2.0 2.5
Eye problems/disorders: Glaucoma 0.4 0.5 1.4 -1.2 0.2 -0.5 0.2 -1.0 -0.0 1.1 -0.1 0.5 -0.1 1.0
Medication: Blood pressure 0.2 0.4 1.1 0.3 -0.8 0.0 -0.3 0.3 -0.1 -0.8 -0.3 -1.1 1.0 0.2
Pain type(s) experienced in last month: Hip pain 0.7 0.8 4.1 -0.3 -0.3 2.0 0.0 -0.2 -0.1 -0.1 0.7 0.3 1.2 1.7
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.1 -0.1 0.3 -1.3 -0.0 -0.3 -0.2 0.6 -0.5 0.3 -1.4 -0.6
High cholesterol (Self-reported) 1.9 3.3 8.6 2.1 -2.9 2.2 -2.1 0.9 -2.0 -1.5 -1.6 -2.1 0.5 -0.0
Medication: Bendroflumethiazide 2.2 3.3 6.2 2.2 -2.5 2.0 -2.3 0.6 -2.4 -1.5 -0.9 -2.0 1.5 0.2
Medication: Paracetamol 0.4 0.6 3.6 0.1 -0.5 0.0 -0.3 -0.3 -0.5 -0.5 -0.3 0.0 1.3 1.9
Medication: Lisinopril 0.5 0.7 1.7 -0.2 0.3 -0.5 0.9 1.1 1.0 -1.3 -0.2 -1.1 1.0 0.2
Medication: Atorvastatin 0.7 0.8 2.4 -0.6 0.6 0.8 1.2 0.1 1.1 -0.9 1.4 -0.3 1.6 0.2
Illnesses of father: High blood pressure 4.0 5.0 8.4 2.3 -2.0 0.1 -2.0 2.8 -1.9 -2.6 -2.7 -2.5 -1.0 -2.9
Alcohol drinker status: Never 2.0 2.4 5.4 1.9 -2.3 0.1 -2.0 1.0 -2.1 -0.4 -2.1 -0.6 -1.6 -0.8
Ever smoked 2.8 5.0 12.5 -2.0 2.5 0.4 2.7 -1.7 2.7 0.3 2.1 1.4 2.9 3.5
Basal metabolic rate 0.8 4.6 13.0 2.7 -3.6 1.3 -3.3 0.9 -3.4 -0.7 -0.5 -0.9 -0.8 -1.7
Leg fat percentage (left) 0.5 1.8 7.1 1.1 -2.1 2.7 -0.7 0.6 -0.7 -1.2 0.6 -0.6 1.5 1.3
Arm fat-free mass (left) 0.7 3.6 11.2 2.0 -3.4 0.5 -3.0 0.2 -3.1 0.4 -0.4 -0.3 -1.5 -1.5
Number of operations (self-reported) 0.7 1.1 4.0 -1.2 0.1 1.0 0.7 -1.1 0.7 1.1 0.6 1.2 0.4 2.0
Average weekly beer plus cider intake 0.3 0.4 1.1 -0.6 0.6 0.7 -0.0 -1.0 0.1 0.9 0.3 0.8 -0.7 0.2
Irritability 0.9 1.5 4.6 -1.6 0.4 0.6 0.1 -2.1 0.3 1.6 1.1 1.7 0.7 1.1
Risk taking 0.5 0.7 5.0 -0.3 0.5 0.0 0.1 -0.3 0.3 0.2 0.9 0.9 0.4 2.2
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.3 1.0 -0.8 0.7 -0.4 0.3 -0.5 -0.4 -1.1 -0.5 -0.2 0.0
Fractured/broken bones in last 5 years 1.5 2.0 3.8 -1.9 1.7 -0.7 1.6 -1.0 1.6 0.6 1.7 0.9 0.9 1.9
Age started oral contraceptive pill 0.5 0.6 1.8 -1.0 0.6 0.1 0.7 -0.7 0.8 0.5 1.3 0.9 0.4 0.5
Diastolic blood pressure, automated reading 1.1 3.3 10.1 1.7 -3.2 1.5 -2.0 1.5 -2.2 -0.8 -1.5 -1.7 -1.3 -1.7
Ever depressed for a whole week 1.1 1.4 3.9 -0.6 -0.6 0.4 -0.5 -2.0 -0.6 1.9 1.4 1.8 -0.5 0.6
Unable to work because of sickness or disability 0.3 0.4 1.2 0.6 -0.7 0.9 -0.4 0.6 -0.4 -0.1 -0.2 0.2 -1.1 -0.4
Commuting to job workplace: Cycle 1.0 1.2 4.6 -0.6 0.3 1.4 0.9 -0.9 0.8 0.1 1.8 0.2 2.1 1.0
Myopia 2.5 3.6 6.9 -2.6 1.5 -0.1 1.8 -2.6 1.8 2.0 2.2 1.9 1.3 2.0
Vascular/heart problems diagnosed by doctor 2.0 5.5 10.1 -2.6 3.2 -1.7 2.3 -2.6 2.3 2.6 3.0 2.8 0.1 0.5
Cholesterol lowering medication 0.5 0.7 3.2 0.3 -0.1 0.7 0.2 0.3 0.3 -1.5 0.3 -1.3 1.8 0.2
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.4 1.3 -1.4 0.8 -1.5 -0.1 -1.5 0.1 -0.7 -0.2 0.1 0.1
Pain experienced in last month 0.6 1.0 3.1 0.8 0.6 -0.9 0.6 1.4 0.4 -1.8 0.0 -1.3 0.5 -1.2
Supplements: Calcium 0.9 1.0 2.2 -0.4 1.5 0.6 1.0 0.3 1.0 -1.2 1.4 -0.5 1.1 -1.2
Basal cell carcinoma (self-reported) 0.3 0.3 1.1 0.0 -0.9 -0.6 -0.5 -0.1 -0.4 0.5 -0.5 -0.2 -1.0 0.1
Heart attack/myocardial infarction (self-reported) 2.5 3.2 6.0 -2.4 1.9 -0.6 2.4 -1.3 2.4 1.2 1.5 2.3 0.2 1.9
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.4 -0.3 0.6 1.2 0.9 -0.3 0.8 -0.5 1.0 0.2 1.2 0.3
Heart disease (siblings) 0.2 0.3 0.7 -0.1 0.5 -0.8 0.6 0.4 0.7 0.0 -0.7 0.3 -0.6 -0.8
Alcohol drinker status: Previous 1.4 1.6 3.5 -1.6 1.1 0.2 1.8 -1.1 1.9 0.5 1.4 0.9 1.1 1.3
Pack years of smoking 0.3 0.5 1.2 0.4 -0.9 1.0 -0.0 1.1 0.0 -0.3 -0.9 -0.6 -0.7 -0.4
Impedance of whole body 1.0 5.0 12.5 -3.5 3.2 -2.0 1.8 -2.7 1.9 2.3 1.2 2.2 -0.5 1.3
Leg fat mass (left) 0.8 3.2 9.5 2.1 -3.0 3.1 -1.8 1.0 -1.8 -1.6 0.3 -1.0 1.2 0.4
Arm predicted mass (left) 0.7 3.4 11.2 2.1 -3.3 0.4 -2.9 0.2 -3.0 0.3 -0.2 -0.2 -1.3 -1.5