Hub : Genes

IL34

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0180	0.0120	1.7e-02	0.017	0.007	0.005	0.006	0.006	2.8e-03	4.1e-02	7.2e-02	0.06	6.1e-02
2	GTEx	Adipose Subcutaneous	0.0440	0.0260	6.6e-03	-0.003	NA	0.001	NA	-0.001	7.5e-01	NA	2.5e-01	NA	3.7e-01
3	GTEx	Brain Putamen basal ganglia	0.2570	0.1020	1.6e-03	0.078	NA	0.108	NA	0.120	6.8e-03	NA	1.6e-03	NA	9.0e-04
4	GTEx	Esophagus Mucosa	0.0440	0.0240	7.2e-03	0.063	NA	0.048	NA	0.058	5.2e-05	NA	3.6e-04	NA	9.3e-05
5	GTEx	Lung	0.1971	0.0544	4.0e-08	0.145	NA	0.127	NA	0.146	3.3e-11	NA	5.8e-10	NA	2.8e-11
6	GTEx	Nerve Tibial	0.0725	0.0347	3.8e-04	0.071	NA	0.049	NA	0.061	9.0e-06	NA	2.1e-04	NA	4.1e-05
7	TCGA	Glioblastoma Multiforme	0.1030	0.0600	8.8e-03	0.043	0.028	0.008	NA	0.027	2.0e-02	4.8e-02	1.8e-01	NA	5.0e-02
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0476	0.0260	7.1e-03	0.009	0.010	0.002	NA	0.004	2.9e-02	2.3e-02	1.9e-01	NA	1.2e-01
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0409	0.0210	2.8e-04	0.009	0.029	0.004	NA	0.011	3.2e-02	2.9e-04	1.0e-01	NA	1.7e-02
10	TCGA	Prostate Adenocarcinoma	0.0411	0.0263	5.2e-03	0.008	0.020	0.004	NA	0.004	4.4e-02	3.2e-03	1.3e-01	NA	1.1e-01
11	TCGA	Stomach Adenocarcinoma	0.1430	0.0570	3.9e-05	0.044	0.073	0.088	NA	0.075	3.7e-04	5.6e-06	6.4e-07	NA	4.4e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	2.4	3.9	10.3	1.6	-0.9	2.4	-0.4	2.5	-0.6	-3.2	0.5	-3.1	2.6	0.3
Bipolar Disorder or Schizophrenia	0.4	0.9	3.2	0.7	-0.2	-0.4	-0.1	1.6	-0.3	-1.8	0.2	-1.7	0.8	-0.6
Depressed Affect (Nagel 2018)	1.7	3.5	10.8	-2.3	0.8	-0.9	0.4	-3.3	0.4	2.7	1.6	2.8	0.5	1.9
Depression (Nagel 2018)	1.3	2.0	5.4	-1.2	0.2	-2.3	-0.1	-2.3	-0.1	1.9	0.6	2.1	-0.6	1.1
Intelligence (Savage-Jansen 2018)	1.9	5.9	21.5	0.4	1.5	2.1	1.9	1.7	2.0	-3.5	2.1	-2.1	4.6	2.4
Neuroticism (Nagel 2018)	1.5	3.6	11.2	-2.7	0.4	-0.5	0.0	-3.3	0.1	2.9	1.5	2.7	0.5	1.7
Schizophrenia (2018)	0.4	0.8	5.9	-0.4	0.4	-2.4	0.2	0.1	0.1	0.3	-0.1	0.3	-1.1	-1.0
Schizophrenia vs Biploar Disorder	2.4	3.1	7.0	-2.0	1.5	-2.6	0.6	-1.8	0.8	2.6	-0.0	2.6	-1.9	0.3
Worry (Nagel 2018)	1.0	2.1	6.3	-2.0	0.4	0.3	-0.1	-2.5	-0.1	2.1	1.1	1.9	0.9	1.7
Alzheimer’s Disease (in mother)	1.6	1.9	5.1	-0.6	-1.4	1.6	-1.2	-2.3	-1.3	2.3	0.4	0.9	0.9	1.1
Alzheimer’s Disease (in father)	4.4	4.7	8.2	-2.8	2.3	-2.0	2.0	-2.5	1.9	2.3	0.8	2.6	-0.1	2.9
Alzheimer’s Disease (including proxy)	3.4	4.9	20.3	-2.3	-0.1	-0.6	-0.3	-3.8	-0.7	4.5	0.0	2.9	-1.4	1.7
Crohns Disease (2017)	1.3	2.8	7.2	1.4	-2.5	-1.1	-1.3	2.1	-1.5	-0.3	-1.8	-0.8	-2.7	-1.3
Irritable Bowel Disease (IBD)	0.3	0.6	3.5	-0.4	-1.0	-0.8	0.2	0.7	-0.2	0.8	-0.0	0.4	-1.9	-0.4
Ulcerative Colitis (UC)	0.2	0.4	1.2	-1.1	0.3	0.1	0.9	-0.1	0.6	0.9	0.6	0.6	-0.6	0.4
Major Depression (MDD)	0.2	0.3	0.7	0.6	-0.8	0.1	-0.5	-0.5	-0.5	0.5	0.8	0.6	-0.4	0.0
Reaction Time	2.6	5.0	9.4	2.9	-3.0	1.8	-1.8	1.7	-2.1	-2.8	-0.4	-2.7	3.1	-0.2
Verbal and Numeric Reasoning (VNR)	1.5	3.5	10.4	0.1	2.0	0.8	1.8	1.3	2.1	-2.8	1.0	-1.5	3.2	1.9
Breast Cancer	0.7	1.6	3.7	-1.0	1.8	-0.9	1.9	-1.2	1.7	0.8	0.6	0.6	1.1	1.5
Ovarian Cancer	1.2	1.6	4.1	0.9	-0.3	-0.1	-0.6	1.7	-0.4	-1.8	-1.6	-2.0	-0.2	-1.9
Prostate Cancer	0.2	0.2	1.0	1.0	-0.5	-0.4	-0.5	0.1	-0.7	-0.3	0.2	0.2	0.5	-0.2
Age at First Birth	0.3	0.4	1.8	0.1	0.5	0.1	0.2	-1.0	0.3	0.6	1.3	0.8	0.4	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	4.0	0.6	-1.2	2.0	-0.9	0.4	-0.8	-0.4	-0.1	-0.8	0.3	0.1
Coronary Artery Disease (CAD)	1.4	1.7	3.1	1.4	-0.9	-1.0	-0.6	1.7	-0.7	-1.2	-1.7	-1.6	-1.1	-1.8
Crohns Disease (2012)	1.3	2.1	8.4	0.5	-1.5	-2.2	-0.9	1.7	-1.0	-0.3	-1.1	-0.4	-2.9	-1.3
Mean Putamen Volume	1.7	1.9	3.9	1.4	-1.3	0.8	-1.3	2.0	-1.2	-1.8	-1.5	-1.4	-0.7	-1.4
Fasting Glucose	0.5	0.6	4.6	-0.2	0.2	-0.4	0.1	-0.2	-0.1	0.6	0.5	0.1	-0.9	-2.1
HbA1C	0.7	0.8	3.5	-0.3	0.0	1.3	-0.2	-0.2	-0.1	-0.6	-0.2	-0.7	1.4	1.9
HDL Cholesterol	0.6	1.0	4.9	-0.3	0.0	-1.1	-0.0	-1.3	-0.1	1.1	0.9	1.2	0.3	2.2
LDL Cholesterol	0.1	0.2	0.8	0.3	-0.2	0.2	-0.2	0.3	-0.2	0.2	-0.5	-0.5	-0.9	-0.3
Lupus	0.6	1.0	1.9	-1.1	0.8	-1.3	1.4	-1.2	0.8	0.8	0.8	1.1	0.3	0.4
Neuroticism (2016)	0.9	1.3	2.7	-1.2	1.0	-1.6	0.9	-1.5	1.0	1.2	0.1	1.4	-0.2	1.3
Primary Biliary Cirrhosis	1.5	2.2	4.9	-1.8	2.1	-0.1	2.0	-0.8	2.2	0.7	1.3	1.1	0.8	1.5
Rheumatoid Arthritis	0.5	0.8	1.7	1.0	-0.8	1.2	-0.9	0.5	-0.9	-0.9	-0.6	-0.6	0.4	-1.3
Schizophrenia (2014)	0.3	0.6	4.1	-0.6	0.4	-2.0	-0.0	-0.5	-0.1	0.5	0.5	0.4	-0.7	-0.7
Triglycerides	0.4	0.6	1.4	0.9	-0.7	-0.0	-0.7	1.1	-0.6	-1.1	-0.8	-1.2	0.3	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.1	-0.0	0.7	-0.1	0.3	0.1	-0.4	-0.7	-0.3	0.1	0.1
Ulcerative Colitis	0.7	1.0	3.2	-1.5	1.1	0.2	1.8	0.2	1.5	0.0	1.2	0.5	-0.1	0.6
Blood Eosinophil Count	0.9	7.3	14.4	-3.8	2.4	0.4	3.2	-2.4	3.4	2.8	2.9	3.0	1.0	2.7
Blood Platelet Count	0.6	7.0	17.2	-3.6	4.0	-1.0	4.2	-0.9	4.2	0.8	2.2	2.3	0.6	0.9
Blood Red Count	0.3	3.1	14.5	0.5	0.4	3.8	0.4	0.4	0.7	-1.8	0.9	-2.0	3.2	-0.7
Blood White Count	0.6	4.2	12.2	-1.9	2.3	0.2	3.5	-0.3	3.5	-0.4	2.4	0.7	2.1	1.6
Heel T-Score	0.2	1.6	4.3	1.5	-1.3	-0.5	-1.1	0.9	-1.1	-0.3	-1.9	-2.1	-0.9	-1.1
BMI	2.2	13.0	45.0	4.1	-4.4	6.7	-2.9	3.4	-2.6	-4.0	-1.7	-3.3	2.4	-0.1
Height	0.6	12.1	32.0	-0.5	-1.8	-4.0	-4.0	-3.5	-4.0	4.5	-0.8	2.4	-5.7	-3.3
Waist Hip Ratio (WHR)	0.1	0.6	2.4	-0.6	1.5	1.0	1.2	-0.2	0.9	-0.4	-0.3	-0.4	0.3	0.2
Systolic Blood Pressure	3.6	18.0	33.1	5.1	-4.7	2.1	-4.6	4.4	-4.3	-4.6	-4.6	-5.8	0.4	-3.2
Smoking Status	4.6	11.0	23.6	-4.0	3.1	-0.3	3.8	-3.1	3.8	1.9	3.4	3.1	2.8	4.9
Allergy or Eczema	0.1	0.2	0.6	-0.3	0.1	0.7	-0.3	-0.7	-0.2	0.7	-0.5	-0.0	0.1	0.5
Cardiovascular Disease	4.4	14.4	23.7	4.6	-4.9	2.6	-4.4	3.6	-4.0	-3.8	-4.3	-4.5	-0.6	-2.2
Hypothyroidism (self reported)	1.0	2.2	5.5	1.3	-1.0	2.1	-1.2	1.6	-0.8	-2.3	-0.7	-2.0	1.4	-0.8
Respiratory disease	1.5	3.3	6.0	-2.4	1.6	0.7	1.9	-2.1	1.9	1.7	2.3	1.8	1.3	1.7
Type 2 Diabetes (T2D) (2018)	1.1	2.0	5.3	1.8	-0.9	1.6	-0.1	2.2	-0.1	-2.3	-1.4	-1.6	1.1	0.2
Lung FEV1/FVC ratio	0.5	2.7	7.8	2.8	-1.6	1.2	-2.1	0.7	-2.0	-1.9	-0.9	-1.6	1.3	0.1
Lung FVC	4.4	22.1	35.5	5.4	-5.3	1.7	-6.0	4.4	-5.8	-3.1	-5.8	-4.2	-3.3	-4.8
Neuroticism	1.6	3.9	11.5	-2.8	0.8	-1.0	0.5	-3.4	0.4	2.9	1.5	2.7	0.5	1.8
Chronotype (morning person)	0.9	2.0	9.9	0.8	-0.7	-1.7	-0.8	0.7	-0.9	0.7	-2.2	0.3	-3.1	-0.9
Hair Pigment	0.2	5.6	10.8	-3.1	3.3	-0.4	2.7	-2.4	2.7	1.6	2.3	2.2	1.1	2.5
Tanning	0.0	0.4	1.4	1.0	-0.4	-0.2	-0.1	1.0	-0.3	-0.7	-0.1	-0.5	0.0	-1.2
Hand grip strength (left)	1.5	4.0	9.6	2.1	-2.5	-0.8	-3.1	-0.0	-3.1	0.8	-1.1	-0.1	-2.0	-2.8
Number of treatments/medications taken	1.7	3.0	5.1	1.9	-2.0	1.9	-1.3	1.6	-1.2	-2.3	-1.9	-2.2	1.4	0.9
Average weekly spirits intake	0.7	0.9	2.0	-0.5	1.0	0.8	1.4	0.8	1.3	-1.3	0.1	-1.2	0.6	0.6
Sensitivity / hurt feelings	1.2	2.1	5.1	-2.3	1.0	-1.1	0.7	-2.0	0.7	2.3	0.5	1.9	-1.2	0.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	-0.2	-0.1	-1.4	-0.9	-1.2	-0.8	0.8	-0.2	0.9	-0.2	1.0
Hearing difficulty/problems: Yes	0.1	0.2	0.7	0.5	-0.8	0.4	-0.5	0.5	-0.3	-0.3	0.2	0.3	-0.1	0.2
Relative age of first facial hair	5.3	10.8	19.3	-4.4	4.4	-3.6	4.0	-2.2	3.9	2.6	2.7	3.3	-0.0	2.4
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.6	-2.1	1.6	0.7	1.6	-1.6	1.8	1.0	1.5	1.4	1.6	1.9
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	-0.7	-0.1	-0.3	-0.0	-0.7	0.0	0.2	0.7	0.1	0.8	0.7
Ever had hysterectomy (womb removed)	1.5	1.7	3.7	1.1	-1.2	0.8	-1.4	1.3	-1.4	-1.6	-1.1	-1.9	0.2	-1.6
Systolic blood pressure, automated reading	3.2	9.3	20.2	3.9	-4.5	1.7	-3.7	2.6	-3.7	-2.6	-2.5	-3.6	0.4	-1.9
Eye problems/disorders: Diabetes related eye disease	2.9	3.1	7.2	2.1	-0.8	1.7	-1.1	2.6	-0.8	-2.7	-1.7	-2.4	0.7	-1.4
Angina	1.6	2.2	4.6	-1.7	1.0	-1.0	2.0	-1.1	1.8	0.8	1.7	1.3	0.6	2.1
Medication for hormone replacement therapy	0.3	0.3	1.6	-0.2	0.7	-1.3	0.2	0.1	0.3	-0.4	-0.0	0.2	-0.4	1.0
Vitamin and mineral supplements	2.6	3.5	15.1	0.8	0.4	2.6	1.1	1.2	0.9	-2.8	1.3	-1.8	3.9	0.1
Supplements: Zinc	0.9	0.9	2.7	-0.9	0.9	-1.2	0.9	-0.2	1.0	1.1	-0.2	0.8	-1.6	-0.8
Medication: Co-codamol	2.7	3.1	6.4	-2.2	1.8	-0.9	2.5	-1.5	2.5	0.9	1.9	1.3	0.9	1.8
Medication: Metformin	1.3	1.8	5.7	1.4	-0.1	2.1	0.2	1.6	0.3	-2.4	-0.7	-1.3	1.7	0.7
Diabetes (father)	1.3	1.5	4.5	0.7	1.0	0.9	1.5	1.7	1.3	-2.1	-0.4	-1.5	1.0	-0.5
Diabetes (mother)	2.7	3.5	5.9	2.3	-1.8	1.8	-1.6	2.4	-1.4	-2.0	-2.4	-2.1	-0.3	-1.3
Severe depression (siblings)	0.3	0.4	1.7	0.2	0.4	1.0	0.1	-0.2	0.1	-0.5	-0.1	-0.6	1.3	0.8
Pack years adult smoking proportion	0.4	0.6	1.5	0.7	-0.9	0.9	-0.1	1.2	-0.1	-0.5	-1.0	-0.7	-0.7	-0.7
Impedance of leg (right)	1.4	7.0	17.1	-3.7	2.5	-2.5	1.2	-3.8	1.3	4.1	0.9	3.1	-1.8	1.5
Leg fat-free mass (left)	0.8	4.5	10.8	2.9	-3.3	1.4	-2.9	1.6	-3.0	-1.6	-0.4	-1.4	-0.2	-1.8
Trunk fat percentage	0.7	3.0	11.2	1.2	-1.9	3.4	-0.9	1.1	-0.9	-2.1	0.8	-1.2	2.4	1.1
Hand grip strength (right)	1.1	3.0	8.1	1.9	-2.0	-0.5	-2.9	-0.3	-2.8	1.0	-0.9	-0.0	-1.5	-2.2
Townsend deprivation index at recruitment	0.5	0.7	3.3	-0.4	0.7	-0.8	0.8	-0.6	0.8	0.5	0.6	0.9	0.2	1.8
Current tobacco smoking	2.1	3.5	10.5	-2.0	2.1	0.1	1.9	-1.8	2.0	0.9	1.3	1.9	1.5	3.2
Average weekly fortified wine intake	2.7	3.1	4.4	-2.1	1.7	-0.1	1.8	-2.1	1.7	1.9	2.0	2.0	1.0	1.9
Maternal smoking around birth	0.4	0.6	2.8	0.8	-0.6	-0.4	0.0	1.0	0.0	-0.6	0.1	-0.6	-0.9	-1.7
Fed-up feelings	0.9	1.7	5.2	-1.1	0.1	-1.3	-0.7	-2.3	-0.5	2.0	0.2	1.8	-0.8	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	4.5	-1.3	0.7	-1.3	0.5	-1.9	0.6	1.9	0.3	2.1	-0.8	1.2
Relative age voice broke	0.5	0.7	1.9	-1.0	1.4	-1.4	0.8	-0.5	0.7	0.8	0.2	0.8	-0.6	-0.1
Taking other prescription medications	0.5	0.8	2.6	-0.4	-0.9	1.6	-0.2	-0.9	0.0	0.4	0.1	0.2	1.3	1.5
Age when periods started (menarche)	1.0	2.3	10.8	0.1	-0.1	-1.7	-1.3	-0.2	-1.4	1.4	-1.5	0.4	-3.3	-2.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	0.4	0.5	-0.0	0.1	0.9	0.1	-1.2	-0.8	-0.9	0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.2	0.8	-1.1	-1.1	-0.8	1.1	-0.9	-0.4	-1.4	-1.8	-0.8	-0.8
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.1	-1.8	0.8	-0.2	0.6	-1.5	0.4	1.4	0.7	1.1	-0.2	0.8
Qualifications: CSEs or equivalent	1.0	1.4	3.1	0.7	-0.6	-0.9	-1.0	1.4	-1.1	-0.7	-1.4	-0.7	-1.7	-1.8
Serious illness, injury or assault to yourself	1.4	1.6	4.1	1.3	-1.3	1.0	-1.0	2.0	-0.9	-1.2	-2.0	-1.2	-0.9	0.0
High blood pressure	3.9	10.9	18.8	3.8	-4.3	2.6	-3.5	3.4	-3.5	-3.4	-3.9	-3.9	0.1	-0.9
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.8	-0.7	0.5	0.1	0.1	-0.8	0.1	0.9	0.1	0.7	-0.1	0.3
Multivitamins +/- minerals	1.9	2.4	10.6	0.6	-1.1	-1.8	-1.8	0.4	-1.6	0.9	-2.0	0.4	-3.2	-0.6
Stomach or abdominal pain in last month	0.3	0.3	1.1	-1.0	0.6	-0.1	0.7	-0.7	0.6	0.3	-0.0	0.5	0.3	0.6
Supplements: Glucosamine	2.1	2.8	5.2	2.3	-2.0	0.7	-1.5	2.0	-1.7	-2.0	-1.8	-2.1	0.2	0.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.1	0.8	-0.7	0.3	-1.0	-0.9	-1.2	-0.2	-0.5	-0.3	1.8	0.4
Medication: Atenolol	0.6	0.8	2.7	1.1	-1.7	0.4	-0.7	1.0	-0.6	-0.8	-0.6	-1.0	-0.7	-0.4
Medication: Levothyroxine sodium	1.4	2.3	7.1	1.2	-1.3	2.7	-1.2	0.6	-1.0	-2.1	-0.1	-1.6	2.4	0.2
Sitting height	1.4	9.9	24.2	1.7	-4.1	-1.1	-4.9	-1.1	-4.7	2.2	-1.8	0.1	-4.4	-3.5
Chronic bronchitis/emphysema (father)	0.5	0.6	2.1	1.0	-1.1	0.5	-0.4	0.6	-0.8	-0.4	-0.8	-0.7	-0.5	-1.5
High blood pressure (mother)	0.7	1.0	2.0	1.1	-1.4	1.4	-0.9	0.7	-0.8	-1.0	-1.1	-1.2	0.1	-0.7
Body mass index (BMI)	1.4	5.8	18.4	2.7	-3.0	4.3	-1.4	2.3	-1.4	-3.0	0.3	-2.0	2.6	0.5
Impedance of leg (left)	1.8	8.6	20.2	-3.9	2.6	-3.1	1.4	-4.1	1.5	4.5	0.9	3.6	-2.2	1.8
Leg predicted mass (left)	0.9	4.6	11.2	2.9	-3.3	1.4	-3.0	1.6	-3.1	-1.6	-0.5	-1.5	-0.1	-1.8
Trunk fat mass	0.8	3.2	10.2	1.8	-2.7	3.2	-1.8	1.1	-1.8	-1.8	0.5	-1.1	1.5	0.4
Waist circumference	1.2	4.4	18.1	2.0	-2.3	4.3	-1.2	1.5	-1.2	-2.5	0.2	-1.8	2.5	0.6
Number of incorrect matches in round	1.1	1.8	5.8	0.6	-2.4	1.0	-1.9	-0.8	-2.0	0.5	-1.2	-0.8	1.2	1.1
Past tobacco smoking	2.1	3.9	8.2	1.7	-2.1	-0.7	-2.7	0.8	-2.6	0.3	-2.2	-0.7	-2.8	-2.9
Alcohol usually taken with meals	0.2	0.4	1.6	1.0	-1.2	0.4	-0.5	-0.0	-1.0	0.1	-0.3	0.2	0.4	0.1
Nervous feelings	1.2	2.3	7.0	-2.1	0.9	-0.6	0.6	-2.6	0.4	2.1	1.4	1.9	0.9	1.3
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	10.0	-1.6	0.1	-1.1	-0.7	-2.8	-0.8	3.2	0.5	2.7	-1.1	0.8
Hearing difficulty/problems with background noise	0.5	0.7	1.4	0.9	-1.2	0.5	-1.1	0.7	-0.9	-0.8	-0.5	-1.0	0.1	-1.0
Hair/balding pattern: Pattern 2	0.5	0.6	2.7	0.2	1.3	-1.6	0.6	0.5	0.6	-0.9	0.3	0.1	0.0	0.7
Had menopause	1.0	1.2	5.4	-0.2	-0.9	1.4	-0.6	-1.1	-0.7	-0.1	1.0	-0.5	2.3	1.4
Had other major operations	0.5	0.6	1.5	-0.5	-1.1	0.2	-0.7	-1.0	-0.9	1.2	-0.6	0.6	-0.1	1.0
Forced vital capacity (FVC)	2.7	10.3	22.6	2.8	-3.1	-0.1	-4.6	1.3	-4.4	-0.1	-3.8	-1.6	-3.8	-4.8
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	6.2	1.7	-2.0	-0.6	-1.7	1.6	-1.8	-0.8	-1.8	-2.5	-0.6	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	2.0	-0.9	-0.1	-0.6	-0.1	-1.0	-0.1	1.4	0.1	1.3	-1.1	0.4
Qualifications: None of the above	0.9	2.0	8.0	-0.9	-0.6	1.1	-0.1	-1.6	-0.2	1.9	0.4	2.2	0.3	2.8
Financial difficulties in last 2 years	0.4	0.5	1.2	0.0	-0.5	-0.8	-0.7	-0.9	-0.6	0.9	0.1	1.1	-0.9	0.7
Mouth/teeth dental problems	0.6	1.0	2.1	0.9	-1.4	-0.4	-1.1	-1.1	-1.0	0.5	1.3	0.6	1.3	0.7
Heart attack	2.0	2.6	5.0	-2.1	1.7	-0.5	2.2	-1.3	2.2	1.2	1.2	2.1	0.0	1.7
Allergy	0.2	0.5	1.2	1.1	-0.9	-0.3	-0.8	0.7	-0.8	-0.6	-0.5	-0.7	-0.2	-0.8
Pain all over the body in last month	1.1	1.2	4.7	0.9	-0.8	0.8	-0.8	0.8	-0.8	0.4	-0.7	0.1	-2.2	-2.0
Diabetes (self-reported)	1.7	2.7	7.4	1.8	-0.6	2.0	-0.0	2.5	0.1	-2.7	-1.7	-2.0	1.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	-0.1	0.4	-0.6	0.1	-0.4	-0.1	0.3	0.1	0.4	0.3	0.7
Medication: Ramipril	0.4	0.5	2.0	-0.3	0.8	-0.5	0.3	-0.9	0.5	0.9	-0.5	0.8	-0.4	1.4
Medication: Simvastatin	1.0	1.5	2.5	1.3	-1.3	1.4	-0.9	1.1	-0.8	-1.4	-1.5	-1.6	0.8	0.9
Fluid intelligence score	1.5	3.1	11.5	1.3	0.7	-0.1	0.9	2.8	1.1	-3.4	-0.1	-2.6	1.8	0.2
Illnesses of siblings	1.8	2.5	4.3	-1.7	2.1	-1.7	1.6	-1.4	1.6	2.0	1.0	2.0	-1.0	0.6
Neuroticism score	1.4	3.0	7.5	-2.7	1.4	-1.1	0.7	-2.7	0.8	2.3	1.0	2.3	0.3	1.6
Weight	0.7	3.6	10.6	2.2	-3.2	2.8	-2.5	0.9	-2.5	-1.3	0.2	-0.9	0.8	-0.4
Impedance of arm (right)	0.6	2.8	10.1	-2.5	3.2	-1.3	1.9	-1.2	1.9	0.9	0.8	1.3	-0.1	1.1
Arm fat percentage (right)	1.2	4.6	18.1	1.5	-1.5	4.3	-0.2	1.9	-0.2	-3.0	1.1	-1.6	3.1	1.2
Trunk fat-free mass	0.8	4.5	12.1	2.2	-3.5	0.2	-3.5	0.1	-3.5	0.5	-0.7	0.0	-2.1	-1.9
Hip circumference	1.4	6.0	17.1	2.5	-3.4	4.1	-2.3	1.7	-2.2	-2.6	0.5	-1.9	2.6	-0.2
Time employed in main current job	0.3	0.4	1.0	-0.7	0.6	-1.0	0.7	-0.4	0.6	0.9	0.6	0.5	-0.4	-0.1
Alcohol intake versus 10 years previously	1.2	1.8	4.8	1.7	-2.2	1.5	-2.0	0.1	-1.9	-0.4	-0.7	-0.3	0.5	1.1
Father’s age at death	0.5	0.7	1.4	-1.2	0.8	-0.8	0.8	-0.7	0.6	0.7	0.3	0.7	-1.0	-1.0
Worrier / anxious feelings	1.0	1.9	4.5	-2.1	1.2	-0.9	0.8	-2.1	0.4	1.4	0.5	1.3	1.1	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.7	-0.3	0.1	-0.4	-0.3	-0.1	0.1	0.5	-0.9	0.6	-1.6	-0.7
Falls in the last year	0.7	0.9	3.4	-0.2	-0.7	1.5	-0.1	-0.8	0.0	0.1	1.8	-0.0	1.4	1.2
Hair/balding pattern: Pattern 3	1.0	1.5	6.9	-0.3	-0.0	2.4	0.4	0.0	0.4	-0.7	1.6	-0.4	2.6	0.2
Number of live births	0.4	0.6	1.4	0.4	-0.7	-1.2	-0.8	-1.0	-1.0	0.9	0.3	1.1	-0.4	0.1
Forced expiratory volume in 1-second (FEV1)	3.2	10.9	24.1	3.5	-3.3	0.8	-4.9	1.6	-4.7	-0.8	-3.6	-2.1	-2.8	-4.7
Pulse rate	1.5	2.5	11.5	0.9	-0.7	3.4	-0.4	1.2	-0.2	-1.8	-0.1	-1.8	2.5	-0.3
Happiness	1.3	1.6	5.1	-0.8	0.3	-2.3	0.5	-1.7	0.3	1.8	0.1	1.7	-1.4	0.4
Noisy workplace	1.7	2.1	12.5	-0.4	-0.1	-1.4	0.3	-0.2	0.2	1.8	-0.9	1.7	-3.5	-1.3
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.6	0.6	0.8	-0.0	0.8	0.8	0.8	-1.6	0.9	-1.2	1.9	0.1
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	8.1	1.6	-0.2	1.4	-0.2	1.9	-0.2	-2.9	-0.2	-2.8	1.7	-1.5
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	-0.3	-0.1	-0.7	0.4	1.4	0.5	-1.2	-1.2	-1.0	-0.7	-0.8
Asthma	2.2	4.3	6.3	-2.5	1.9	0.0	2.5	-2.2	2.5	1.8	2.3	2.2	1.2	2.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.9	0.9	-1.0	0.8	-0.8	-0.2	-0.7	-0.2	-0.2	-0.2	0.8	1.4
Medication: Cholesterol lowering	1.5	2.3	5.2	1.5	-1.5	2.3	-0.9	1.9	-0.8	-1.9	-1.9	-1.8	0.1	0.4
Depression (self-reported)	0.4	0.4	2.2	0.0	0.1	1.5	-0.3	-0.2	-0.2	-0.3	0.2	-0.4	1.2	1.0
Medication: Lansoprazole	0.2	0.2	0.5	-0.7	0.7	-0.4	0.5	-0.2	0.5	-0.5	-0.4	-0.0	0.1	0.3
Prospective memory result	1.0	1.3	3.7	-1.2	1.1	-0.2	0.7	-1.2	0.6	1.8	0.3	1.9	-1.4	0.5
Lung cancer (father)	4.5	5.2	9.9	3.1	-2.8	1.5	-2.4	2.2	-2.6	-2.1	-2.4	-2.6	-0.1	-1.6
Illnesses of mother	1.4	1.7	4.5	-1.2	2.1	-0.5	1.3	-1.3	1.2	0.8	1.8	1.2	1.1	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.6	16.5	2.8	-2.7	0.3	-4.1	1.3	-3.9	-0.6	-3.3	-1.7	-2.5	-3.8
Pulse wave Arterial Stiffness index	0.8	0.9	2.8	-1.0	0.2	-0.1	1.2	-0.4	1.2	0.0	1.7	0.5	1.2	1.2
Impedance of arm (left)	0.4	1.9	8.2	-2.1	2.9	-0.7	1.5	-0.9	1.6	0.0	0.8	0.6	0.8	0.8
Arm fat mass (right)	1.0	4.3	15.7	2.0	-2.6	4.0	-1.4	1.6	-1.4	-2.5	0.6	-1.6	2.3	0.4
Trunk predicted mass	0.8	4.5	12.0	2.3	-3.5	0.2	-3.4	0.1	-3.5	0.5	-0.7	-0.0	-2.1	-1.9
Standing height	0.6	6.0	13.9	-0.7	-1.0	-2.7	-2.8	-2.7	-2.8	3.4	-0.0	2.1	-3.7	-2.1
Length of working week for main job	0.4	0.5	1.3	-0.1	0.9	0.4	0.7	1.1	0.6	-1.1	0.6	-0.4	0.7	-0.0
Exposure to tobacco smoke at home	2.3	2.6	5.8	1.8	-2.2	0.3	-2.4	1.3	-2.1	-0.7	-2.1	-1.1	-1.2	-0.8
Breastfed as a baby	0.4	0.5	1.7	0.5	-1.1	0.0	-1.3	-0.1	-1.2	0.3	-0.7	-0.1	-0.3	0.5
Tense / ‘highly strung’	2.5	4.1	8.0	-2.8	1.8	-0.6	1.0	-2.8	1.1	2.5	1.7	2.7	1.0	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.7	0.5	-1.6	0.2	-1.7	-1.5	-1.9	1.0	-0.4	0.5	0.5	0.6
Hair/balding pattern: Pattern 4	0.4	0.9	2.8	0.3	-1.7	0.4	-1.5	-0.4	-1.6	0.8	-0.6	0.1	-0.8	-0.4
Birth weight of first child	1.2	2.1	8.1	-0.5	1.3	0.1	1.0	0.0	1.1	-1.4	2.8	-0.7	2.9	0.8
Peak expiratory flow (PEF)	1.2	2.9	7.7	2.2	-1.8	1.1	-2.8	0.6	-2.5	-0.6	-1.2	-1.0	-0.6	-2.2
Pulse wave reflection index	1.8	2.2	5.2	-1.6	0.8	-2.3	1.5	-1.2	1.3	1.4	2.0	1.7	-0.6	1.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.3	-0.0	-0.7	0.4	-0.8	-1.0	-0.9	1.5	0.4	1.3	-1.1	0.2
Loud music exposure frequency	3.3	3.7	10.7	-2.1	1.0	-0.8	0.7	-2.6	0.9	3.3	0.9	3.3	-1.9	0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	6.1	0.1	1.2	1.2	1.0	0.1	1.0	-0.9	1.6	-0.8	2.5	-0.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.1	-0.0	1.1	0.9	0.7	1.3	0.7	-1.0	-0.8	-1.5	-0.6	-0.5
Blood clot in the leg (DVT)	0.5	0.7	2.0	-0.4	0.7	1.4	0.9	-0.3	0.9	-0.5	0.8	0.1	1.4	0.6
Medication: Paracetamol	0.5	0.9	4.0	0.3	-0.5	0.4	-0.3	-0.2	-0.4	-0.8	-0.4	-0.5	1.9	2.0
Headache pain in last month	0.3	0.5	1.9	-1.4	0.0	-0.4	0.2	-1.1	0.4	1.2	0.2	0.4	-0.0	0.6
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	8.4	-2.8	2.6	-1.7	1.7	-2.8	1.7	2.6	2.9	2.6	0.1	-0.2
Glaucoma (self-reported)	1.5	1.7	4.8	-2.2	1.1	-0.1	1.0	-1.7	0.9	1.7	0.5	1.2	0.2	1.9
Gout (self-reported)	0.9	1.2	5.7	0.5	-0.1	1.0	-0.6	-0.4	-0.4	-0.7	1.6	-0.5	2.4	1.5
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.1	1.0	-1.0	2.3	-1.2	1.1	-0.9	-2.1	-0.3	-1.8	2.1	0.0
Medication: Amlodipine	1.3	1.8	6.2	2.2	-0.9	-0.5	-0.0	2.4	-0.2	-2.5	0.0	-1.4	0.3	-0.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.7	-1.2	1.1	0.9	1.3	-1.0	1.1	0.8	1.2	1.0	0.2	-0.4
Birth weight	0.4	0.8	2.6	-1.0	0.4	-0.3	0.5	-1.2	0.4	0.7	1.0	0.9	0.8	1.6
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.4	0.7	-1.5	-1.1	-1.5	-0.7	-1.3	1.4	-0.8	0.7	-1.8	-1.3
High blood pressure (siblings)	2.8	4.1	6.6	2.1	-2.4	2.3	-2.2	2.0	-2.1	-2.5	-1.5	-2.6	0.8	-0.9
Forced vital capacity (FVC), Best measure	2.4	8.8	17.2	2.6	-2.9	-0.4	-4.1	1.1	-4.0	0.2	-3.8	-1.3	-3.7	-4.1
Body fat percentage	0.7	2.9	12.0	1.2	-2.0	3.5	-0.8	1.0	-0.8	-1.9	0.9	-1.0	2.4	1.2
Leg fat percentage (right)	0.6	2.1	8.8	1.1	-2.1	3.0	-0.9	0.6	-0.8	-1.2	0.7	-0.7	1.7	1.2
Arm fat-free mass (right)	1.0	5.1	15.2	2.5	-3.9	0.5	-3.7	0.3	-3.7	0.2	-0.6	-0.4	-1.5	-1.8
Exposure to tobacco smoke outside home	0.5	0.7	2.4	0.1	0.2	-0.0	-0.5	1.0	-0.4	-0.5	-1.6	-0.9	-1.3	-0.9
Comparative body size at age 10	2.8	7.9	18.6	3.5	-1.9	0.2	-1.4	4.3	-1.5	-2.7	-3.7	-3.0	-2.5	-3.4
Number of full brothers	3.8	4.8	7.3	2.6	-2.6	2.7	-2.5	1.9	-2.2	-2.1	-2.5	-2.3	0.7	-1.1
Worry too long after embarrassment	0.3	0.4	1.6	-0.3	-0.4	0.0	-0.4	0.5	-0.3	-0.1	-1.2	-0.7	-0.7	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.5	0.9	-0.2	1.6	-0.6	-0.1	-0.7	-1.0	0.6	-0.6	1.9	1.3
Wheeze or whistling in the chest in last year	0.6	1.1	3.9	-1.2	0.8	-0.4	1.1	0.0	1.0	1.2	0.2	1.6	-2.0	0.1
Number of children fathered	1.1	1.3	3.6	-0.7	0.2	-1.5	0.6	-1.1	0.7	1.9	0.3	1.9	-1.1	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	6.7	1.0	-1.5	2.6	-1.8	-0.6	-1.8	-0.3	-0.2	-0.8	1.7	0.3
Age at first live birth	0.8	1.3	4.1	-0.9	1.3	-0.2	1.3	-1.1	1.4	1.3	2.0	1.1	0.6	-0.5
Pulse wave peak to peak time	0.8	0.9	2.3	0.9	-0.2	-0.2	-1.3	0.1	-1.3	0.2	-1.5	-0.3	-1.3	-1.3
Health satisfaction	0.8	1.1	3.2	-0.9	0.2	-0.6	0.1	-1.4	0.1	1.8	-0.4	1.6	-1.5	-0.3
Shortness of breath walking on level ground	0.3	0.3	1.5	0.5	-0.2	1.2	-0.6	-0.1	-0.5	-0.6	0.6	0.2	0.4	0.3
Qualifications: College or University degree	0.4	1.3	3.9	1.0	0.7	0.9	0.3	1.7	0.5	-2.0	-0.3	-1.8	1.5	0.2
Eye problems/disorders: None of the above	0.2	0.2	1.0	-0.2	-0.1	-0.2	-0.2	-0.8	-0.3	0.6	1.0	0.3	-0.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	3.0	0.8	-0.7	1.7	-1.0	0.2	-0.9	-0.7	0.4	-0.3	1.3	0.9
Emphysema/chronic bronchitis	1.0	1.1	2.4	-1.4	-0.2	-1.3	-0.3	-0.9	-0.5	1.6	-0.1	1.6	-1.6	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	2.6	-0.2	0.9	-0.6	0.3	-0.0	0.2	0.1	0.9	0.0	-0.4	-1.6
Neck or shoulder pain in last month	0.7	0.9	3.1	-0.9	0.3	-0.1	0.2	-1.4	0.5	1.2	0.9	1.8	-0.7	1.2
Medication: Blood pressure	2.7	4.8	8.6	2.9	-2.8	1.3	-2.4	2.1	-2.3	-2.4	-2.5	-2.6	0.3	0.7
Angina (self-reported)	2.2	2.9	6.6	-2.0	1.2	-1.0	2.2	-1.4	2.0	1.1	2.0	1.6	0.8	2.6
Migraine (self-reported)	0.9	1.1	3.4	0.8	-0.8	1.8	-1.2	0.5	-0.9	-0.9	-1.4	-1.4	0.6	-0.5
Medication: Ibuprofen	0.9	1.0	3.0	1.7	-1.4	0.6	-1.4	-0.1	-1.3	-0.4	-0.6	-0.4	0.5	1.1
Medication: Allopurinol	0.4	0.6	3.2	0.2	-0.0	0.3	-0.2	-0.4	0.0	-0.5	0.6	-0.4	1.8	1.3
Medication: Omeprazole	0.5	0.6	1.6	0.7	-1.3	0.8	-1.0	-0.8	-1.1	0.7	0.3	0.4	0.3	0.6
Medication: Seretide 50 evohaler	1.2	1.3	2.9	-1.2	0.9	1.2	1.6	-0.6	1.4	0.3	1.7	0.9	1.1	1.0
Mean time to correctly identify matches	1.9	3.6	13.0	2.1	-1.9	2.2	-0.8	0.9	-1.0	-2.5	0.4	-2.0	3.6	0.8
Heart disease (mother)	0.5	0.6	2.1	-0.5	0.2	0.0	0.9	1.1	0.7	-0.6	-0.4	-0.5	-0.9	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	2.2	-0.6	0.2	0.6	0.1	-1.5	0.2	1.0	0.5	0.5	0.4	0.5
Whole body fat mass	0.8	3.5	10.8	2.0	-2.9	3.3	-1.9	1.2	-1.9	-1.8	0.4	-1.2	1.5	0.3
Leg fat mass (right)	0.9	3.6	10.7	2.2	-3.0	3.3	-1.9	1.2	-1.9	-1.8	0.2	-1.2	1.4	0.2
Arm predicted mass (right)	0.8	4.2	13.3	2.3	-3.6	0.8	-3.4	0.1	-3.5	0.2	-0.4	-0.5	-1.0	-1.5
Pulse rate, automated reading	1.7	5.6	14.9	2.8	-1.4	3.4	-0.7	2.7	-0.6	-3.9	-0.4	-2.9	2.8	-1.0
Alcohol intake frequency.	0.8	1.9	4.9	2.0	-2.2	-0.6	-1.3	0.8	-1.4	-0.2	-1.7	-0.2	-1.4	-1.7
Comparative height size at age 10	0.1	0.8	2.6	-0.6	-0.5	1.6	-1.3	-1.1	-1.1	0.5	0.6	0.7	0.5	0.6
Number of full sisters	0.8	0.9	2.7	1.6	-1.3	0.8	-1.0	0.6	-0.9	-1.1	-0.6	-0.6	0.7	0.6
Suffer from ‘nerves’	1.2	1.9	5.1	-1.9	0.4	0.1	0.3	-2.1	0.2	2.3	0.6	1.8	-0.2	1.9
Overall health rating	0.2	0.5	1.9	0.2	-0.8	1.4	-0.6	0.3	-0.5	-0.4	-0.7	0.1	-0.9	-1.0
Chest pain or discomfort	0.7	1.0	3.2	-0.3	-0.1	-0.7	-0.0	1.7	-0.0	-0.4	-1.5	-0.4	-1.8	-1.1
Had major operations	0.3	0.3	1.1	-0.3	0.4	1.0	0.6	0.3	0.6	-0.0	0.2	0.6	-0.6	0.6
Age at last live birth	2.3	3.4	6.1	-1.8	1.9	-0.5	1.6	-2.2	1.8	2.1	2.5	2.4	0.7	1.6
Family relationship satisfaction	0.3	0.4	1.6	-0.5	0.1	-0.5	0.2	-1.3	0.2	0.7	0.6	0.6	0.6	-0.2
Leg pain on walking	0.6	0.8	1.3	0.8	-0.5	1.1	-0.8	1.1	-0.6	-1.1	-0.8	-1.0	-0.6	-1.0
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.9	5.3	0.7	-1.0	-1.4	-0.9	1.1	-0.9	-0.1	-1.7	-1.3	-2.1	-2.3
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.0	0.7	-0.7	0.1	-0.6	1.6	-0.8	-0.2	-1.0	-0.4	-1.7	-1.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.1	-1.3	1.4	-1.2	1.4	-0.5	1.3	0.6	1.4	1.1	-0.0	-0.4
Medication: Aspirin	0.4	0.5	1.7	-0.9	0.6	-0.1	1.2	0.7	1.3	-0.4	-0.4	0.1	-0.3	0.5
Supplements: Vitamin C	2.8	3.3	8.7	-2.0	1.4	-2.1	1.2	-2.1	1.1	2.9	0.7	2.5	-1.5	1.1
Knee pain experienced in last month	1.2	1.9	9.3	0.2	-0.8	2.4	-0.1	-0.3	-0.2	-0.6	1.1	-0.4	3.0	1.7
Hypertension (Self-reported)	4.3	11.8	21.4	4.0	-4.6	2.5	-3.9	3.4	-3.8	-3.5	-4.1	-4.0	0.1	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.9	-0.4	0.2	-0.3	-0.0	-0.9	0.1	0.5	0.1	0.6	-0.1	0.2
Illnesses of father: Heart disease	0.1	0.1	0.5	0.3	-0.2	-0.3	0.0	0.3	0.2	-0.5	0.1	-0.6	-0.2	-0.7
Illnesses of siblings: Diabetes	1.5	1.8	4.3	1.2	-0.8	2.1	-0.5	1.8	-0.3	-2.1	-0.7	-1.9	0.7	-1.0
Smoking status: Previous	1.2	1.7	3.4	-1.3	1.1	1.0	1.8	-0.5	1.6	-0.0	1.7	0.7	1.6	1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	4.5	-1.1	-0.3	-0.5	-1.2	-2.1	-0.9	1.7	1.1	1.6	-0.1	0.9
Whole body fat-free mass	0.7	4.2	11.8	2.5	-3.4	0.6	-3.3	0.6	-3.3	-0.3	-0.5	-0.6	-1.3	-1.9
Leg fat-free mass (right)	0.7	3.9	9.2	2.8	-3.0	1.0	-2.7	1.5	-2.8	-1.6	-0.5	-1.3	-0.3	-1.8
Arm fat percentage (left)	1.4	5.7	19.7	2.0	-1.9	4.4	-0.6	2.3	-0.6	-3.5	0.8	-2.0	3.4	0.9
Average weekly red wine intake	1.1	1.7	7.7	0.9	-0.1	1.6	-0.3	0.9	-0.3	-1.7	-0.3	-1.8	2.8	0.6
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.7	0.6	-0.3	-1.5	-0.8	0.7	-1.0	0.1	-0.9	0.4	-1.6	-1.1
Mood swings	1.0	1.8	5.4	-1.3	0.3	0.4	-0.3	-2.3	-0.3	1.3	1.4	1.6	1.5	1.8
Loneliness, isolation	4.1	5.7	14.5	-2.8	2.2	-1.7	1.6	-3.8	1.5	2.9	2.3	3.0	0.6	2.1
Long-standing illness, disability or infirmity	1.9	2.8	12.5	-0.2	0.4	3.5	1.2	1.3	1.3	-2.3	0.0	-1.1	2.6	0.9
Ever had bowel cancer screening	1.9	2.2	4.1	-2.0	1.1	0.8	1.7	-1.6	1.5	1.7	1.9	1.8	0.6	0.7
Diabetes diagnosed by doctor	1.6	2.6	7.2	1.9	-0.9	1.9	-0.0	2.5	0.0	-2.7	-1.5	-2.0	0.8	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.4	-0.5	0.2	-0.9	-0.6	-1.0	0.1	-0.0	0.3	0.4	0.5
Friendships satisfaction	0.5	0.6	1.8	-0.9	1.0	-1.4	0.6	-0.9	0.6	0.7	-0.1	0.1	-0.5	-0.7
Qualifications: nursing, teaching	0.5	0.8	3.3	0.3	1.0	-1.8	1.0	0.8	0.9	-1.0	0.5	-0.4	0.5	-0.8
Commuting to job workplace: Walk	1.1	1.2	2.6	1.6	-0.6	-1.0	-1.1	1.3	-1.0	-1.4	-0.8	-1.6	-0.3	-0.4
Eye problems/disorders: Cataract	1.1	1.3	2.8	1.2	-1.1	1.7	-1.1	1.3	-1.0	-1.0	-1.7	-1.0	-0.4	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.6	-0.8	1.3	0.3	0.7	0.1	1.0	0.2	0.2	0.5	0.2	0.7
Medication for cholesterol	0.2	0.3	1.4	0.1	0.0	0.2	0.1	-0.4	-0.1	1.0	0.6	1.2	-0.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	10.7	-1.7	1.5	-3.0	1.4	-0.2	1.6	1.9	-0.6	1.8	-3.3	-1.0
Back pain experienced in last month	0.8	1.2	3.1	-0.4	-1.0	1.0	-1.2	-1.8	-1.4	1.4	0.4	1.2	0.0	1.2
Mineral and other dietary supplements	0.3	0.4	1.5	-0.2	-0.5	0.0	-0.3	-0.4	-0.2	0.2	0.7	0.6	0.9	1.2
Breast cancer (self-reported)	0.8	0.9	5.8	0.4	-1.2	2.4	-1.1	-0.1	-1.0	0.1	-0.7	-0.1	-0.2	-0.1
Asthma (self-reported)	1.7	3.3	5.2	-2.3	1.8	0.0	2.2	-1.9	2.1	1.6	2.1	1.9	1.1	1.9
Osteoporosis (self-reported)	0.7	0.8	2.6	-1.1	0.7	-0.5	0.8	-0.9	0.5	1.6	0.8	1.2	-1.0	-0.1
Osteoarthritis (self-reported)	0.7	0.9	3.1	-0.1	0.1	1.5	1.2	0.7	0.9	-1.0	0.7	-0.8	1.8	0.3
Medication: Aspirin	0.3	0.4	1.5	-0.2	-0.0	-0.2	0.4	1.2	0.5	-0.6	-1.2	-0.4	-0.9	-0.1
Medication: Gliclazide	0.2	0.2	0.9	0.4	0.2	0.0	0.3	0.8	0.5	-0.4	0.2	-0.2	-0.2	-0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	1.7	-1.0	0.9	0.5	0.3	-1.0	0.2	1.3	0.7	0.8	0.2	1.0
Smoking status: Current	3.3	5.3	14.1	-2.6	2.4	-0.1	2.3	-2.4	2.4	1.4	1.9	2.4	1.9	3.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.6	11.2	2.7	-3.0	1.0	-3.2	1.2	-3.3	-0.8	-2.4	-2.0	-1.1	-3.0
Whole body water mass	0.8	4.4	12.1	2.6	-3.5	0.7	-3.3	0.7	-3.4	-0.4	-0.6	-0.7	-1.2	-1.9
Leg predicted mass (right)	0.8	4.2	10.0	2.9	-3.2	1.0	-2.9	1.6	-2.9	-1.6	-0.5	-1.4	-0.3	-1.8
Arm fat mass (left)	1.3	5.4	16.6	2.5	-2.7	4.1	-1.7	2.0	-1.6	-3.0	0.4	-2.1	2.5	0.2
Number of self-reported non-cancer illnesses	2.1	3.6	12.1	1.0	-1.1	3.5	-0.4	1.6	-0.2	-2.8	-0.7	-2.2	2.7	1.2
Average weekly champagne plus white wine intake	1.6	2.2	6.2	-1.7	0.5	-2.5	0.5	-1.5	0.5	1.9	0.6	1.8	-1.1	1.8
Miserableness	1.1	1.9	5.6	-1.5	1.4	-0.4	0.4	-2.0	0.4	1.5	0.9	1.8	0.8	2.4
Guilty feelings	0.5	0.8	2.7	-1.1	0.4	-0.2	0.5	-1.3	0.3	0.6	1.1	0.6	1.6	1.0
Wears glasses or contact lenses	0.3	0.3	1.4	-0.1	-0.3	-0.9	-0.1	-0.7	0.0	0.1	0.1	-0.1	0.9	1.2
Ever taken oral contraceptive pill	1.6	1.8	5.3	-1.6	2.3	0.2	1.9	-0.0	2.1	-0.2	1.4	0.5	1.2	0.8
Hearing aid user	0.9	1.0	2.9	-1.4	0.9	-0.6	1.0	-0.6	0.8	0.8	0.7	1.4	-0.2	1.7
Mother’s age at death	0.7	0.9	2.7	-0.9	0.5	-1.6	1.0	-0.6	1.0	0.8	0.7	1.0	-0.9	-0.8
Financial situation satisfaction	2.1	2.7	6.8	-1.6	1.1	-2.5	0.8	-1.5	0.7	2.1	1.3	2.6	-1.5	0.8
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.2	-0.0	-1.7	1.8	-1.5	-0.7	-1.4	1.0	-1.0	0.1	-0.3	-0.5
Commuting to job workplace: Public transport	2.9	3.4	6.3	-2.2	2.0	-1.3	2.0	-1.5	2.3	0.6	2.1	1.0	2.0	2.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	-1.2	0.2	-0.5	0.2	-1.0	-0.0	1.1	-0.1	0.5	-0.1	1.0
Medication: Blood pressure	0.2	0.4	1.1	0.3	-0.8	0.0	-0.3	0.3	-0.1	-0.8	-0.3	-1.1	1.0	0.2
Pain type(s) experienced in last month: Hip pain	0.7	0.8	4.1	-0.3	-0.3	2.0	0.0	-0.2	-0.1	-0.1	0.7	0.3	1.2	1.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.1	-0.1	0.3	-1.3	-0.0	-0.3	-0.2	0.6	-0.5	0.3	-1.4	-0.6
High cholesterol (Self-reported)	1.9	3.3	8.6	2.1	-2.9	2.2	-2.1	0.9	-2.0	-1.5	-1.6	-2.1	0.5	-0.0
Medication: Bendroflumethiazide	2.2	3.3	6.2	2.2	-2.5	2.0	-2.3	0.6	-2.4	-1.5	-0.9	-2.0	1.5	0.2
Medication: Paracetamol	0.4	0.6	3.6	0.1	-0.5	0.0	-0.3	-0.3	-0.5	-0.5	-0.3	0.0	1.3	1.9
Medication: Lisinopril	0.5	0.7	1.7	-0.2	0.3	-0.5	0.9	1.1	1.0	-1.3	-0.2	-1.1	1.0	0.2
Medication: Atorvastatin	0.7	0.8	2.4	-0.6	0.6	0.8	1.2	0.1	1.1	-0.9	1.4	-0.3	1.6	0.2
Illnesses of father: High blood pressure	4.0	5.0	8.4	2.3	-2.0	0.1	-2.0	2.8	-1.9	-2.6	-2.7	-2.5	-1.0	-2.9
Alcohol drinker status: Never	2.0	2.4	5.4	1.9	-2.3	0.1	-2.0	1.0	-2.1	-0.4	-2.1	-0.6	-1.6	-0.8
Ever smoked	2.8	5.0	12.5	-2.0	2.5	0.4	2.7	-1.7	2.7	0.3	2.1	1.4	2.9	3.5
Basal metabolic rate	0.8	4.6	13.0	2.7	-3.6	1.3	-3.3	0.9	-3.4	-0.7	-0.5	-0.9	-0.8	-1.7
Leg fat percentage (left)	0.5	1.8	7.1	1.1	-2.1	2.7	-0.7	0.6	-0.7	-1.2	0.6	-0.6	1.5	1.3
Arm fat-free mass (left)	0.7	3.6	11.2	2.0	-3.4	0.5	-3.0	0.2	-3.1	0.4	-0.4	-0.3	-1.5	-1.5
Number of operations (self-reported)	0.7	1.1	4.0	-1.2	0.1	1.0	0.7	-1.1	0.7	1.1	0.6	1.2	0.4	2.0
Average weekly beer plus cider intake	0.3	0.4	1.1	-0.6	0.6	0.7	-0.0	-1.0	0.1	0.9	0.3	0.8	-0.7	0.2
Irritability	0.9	1.5	4.6	-1.6	0.4	0.6	0.1	-2.1	0.3	1.6	1.1	1.7	0.7	1.1
Risk taking	0.5	0.7	5.0	-0.3	0.5	0.0	0.1	-0.3	0.3	0.2	0.9	0.9	0.4	2.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.3	1.0	-0.8	0.7	-0.4	0.3	-0.5	-0.4	-1.1	-0.5	-0.2	0.0
Fractured/broken bones in last 5 years	1.5	2.0	3.8	-1.9	1.7	-0.7	1.6	-1.0	1.6	0.6	1.7	0.9	0.9	1.9
Age started oral contraceptive pill	0.5	0.6	1.8	-1.0	0.6	0.1	0.7	-0.7	0.8	0.5	1.3	0.9	0.4	0.5
Diastolic blood pressure, automated reading	1.1	3.3	10.1	1.7	-3.2	1.5	-2.0	1.5	-2.2	-0.8	-1.5	-1.7	-1.3	-1.7
Ever depressed for a whole week	1.1	1.4	3.9	-0.6	-0.6	0.4	-0.5	-2.0	-0.6	1.9	1.4	1.8	-0.5	0.6
Unable to work because of sickness or disability	0.3	0.4	1.2	0.6	-0.7	0.9	-0.4	0.6	-0.4	-0.1	-0.2	0.2	-1.1	-0.4
Commuting to job workplace: Cycle	1.0	1.2	4.6	-0.6	0.3	1.4	0.9	-0.9	0.8	0.1	1.8	0.2	2.1	1.0
Myopia	2.5	3.6	6.9	-2.6	1.5	-0.1	1.8	-2.6	1.8	2.0	2.2	1.9	1.3	2.0
Vascular/heart problems diagnosed by doctor	2.0	5.5	10.1	-2.6	3.2	-1.7	2.3	-2.6	2.3	2.6	3.0	2.8	0.1	0.5
Cholesterol lowering medication	0.5	0.7	3.2	0.3	-0.1	0.7	0.2	0.3	0.3	-1.5	0.3	-1.3	1.8	0.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.4	1.3	-1.4	0.8	-1.5	-0.1	-1.5	0.1	-0.7	-0.2	0.1	0.1
Pain experienced in last month	0.6	1.0	3.1	0.8	0.6	-0.9	0.6	1.4	0.4	-1.8	0.0	-1.3	0.5	-1.2
Supplements: Calcium	0.9	1.0	2.2	-0.4	1.5	0.6	1.0	0.3	1.0	-1.2	1.4	-0.5	1.1	-1.2
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	0.0	-0.9	-0.6	-0.5	-0.1	-0.4	0.5	-0.5	-0.2	-1.0	0.1
Heart attack/myocardial infarction (self-reported)	2.5	3.2	6.0	-2.4	1.9	-0.6	2.4	-1.3	2.4	1.2	1.5	2.3	0.2	1.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	-0.3	0.6	1.2	0.9	-0.3	0.8	-0.5	1.0	0.2	1.2	0.3
Heart disease (siblings)	0.2	0.3	0.7	-0.1	0.5	-0.8	0.6	0.4	0.7	0.0	-0.7	0.3	-0.6	-0.8
Alcohol drinker status: Previous	1.4	1.6	3.5	-1.6	1.1	0.2	1.8	-1.1	1.9	0.5	1.4	0.9	1.1	1.3
Pack years of smoking	0.3	0.5	1.2	0.4	-0.9	1.0	-0.0	1.1	0.0	-0.3	-0.9	-0.6	-0.7	-0.4
Impedance of whole body	1.0	5.0	12.5	-3.5	3.2	-2.0	1.8	-2.7	1.9	2.3	1.2	2.2	-0.5	1.3
Leg fat mass (left)	0.8	3.2	9.5	2.1	-3.0	3.1	-1.8	1.0	-1.8	-1.6	0.3	-1.0	1.2	0.4
Arm predicted mass (left)	0.7	3.4	11.2	2.1	-3.3	0.4	-2.9	0.2	-3.0	0.3	-0.2	-0.2	-1.3	-1.5