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chr17:73,128,150-74,629,867

Best TWAS P=6.25e-13 · Best GWAS P=1.93e-12 conditioned to 0.171

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TRIM47	0.15	0.12	enet	13	0.14	2.8e-17	-6.1	5.7	1.2e-08	-0.63	0.69	0.31	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TRIM65	0.21	0.17	lasso	5	0.21	5.2e-25	-6.3	-6.3	3.5e-10	0.68	0.18	0.82	FALSE
3	GTEx	Adipose Subcutaneous	TRIM65	0.10	0.07	lasso	4	0.05	3.0e-05	-6.4	-6.7	2.3e-11	0.88	0.02	0.97	FALSE
4	GTEx	Adipose Subcutaneous	FBF1	0.36	0.29	lasso	2	0.29	5.4e-24	-7.0	-7.0	3.3e-12	1.00	0.00	1.00	FALSE
5	GTEx	Adipose Subcutaneous	MRPL38	0.08	0.07	lasso	4	0.06	9.3e-06	-6.2	6.8	1.4e-11	-0.83	0.05	0.95	FALSE
6	GTEx	Adipose Visceral Omentum	FBF1	0.29	0.23	lasso	1	0.22	1.4e-11	-7.0	-7.0	1.9e-12	1.00	0.00	1.00	FALSE
7	GTEx	Artery Aorta	FBF1	0.32	0.27	lasso	2	0.26	2.2e-14	-7.0	-7.1	1.1e-12	1.00	0.00	1.00	FALSE
8	GTEx	Artery Coronary	FBF1	0.41	0.18	lasso	8	0.14	2.2e-05	-7.0	-6.8	1.5e-11	0.97	0.00	1.00	FALSE
9	GTEx	Artery Tibial	TRIM65	0.11	0.03	enet	17	0.04	7.7e-04	-4.6	-5.5	3.9e-08	0.48	0.06	0.35	FALSE
10	GTEx	Artery Tibial	FBF1	0.36	0.33	enet	12	0.33	3.7e-26	-7.0	-7.1	1.2e-12	0.98	0.00	1.00	FALSE
11	GTEx	Brain Caudate basal ganglia	FBF1	0.35	0.20	enet	27	0.19	3.3e-06	-7.0	-6.9	6.1e-12	0.90	0.00	0.99	FALSE
12	GTEx	Brain Cerebellar Hemisphere	TRIM47	0.26	0.08	enet	8	0.11	9.3e-04	-6.1	5.4	7.0e-08	-0.59	0.21	0.19	FALSE
13	GTEx	Brain Cerebellar Hemisphere	RP11-552F3.9	0.28	0.16	lasso	5	0.16	7.0e-05	-4.6	5.5	2.8e-08	-0.57	0.16	0.15	FALSE
14	GTEx	Brain Cerebellum	TRIM47	0.30	0.17	lasso	2	0.17	1.1e-05	-5.2	5.8	4.9e-09	-0.59	0.26	0.42	FALSE
15	GTEx	Brain Cerebellum	TRIM65	0.34	0.14	enet	8	0.19	2.8e-06	-6.0	-6.4	1.6e-10	0.81	0.02	0.93	FALSE
16	GTEx	Brain Cortex	TRIM65	0.36	0.15	enet	22	0.24	3.7e-07	-6.3	-5.2	2.1e-07	0.65	0.07	0.88	FALSE
17	GTEx	Brain Cortex	FBF1	0.34	0.25	lasso	3	0.25	1.5e-07	-6.4	-7.0	3.7e-12	0.91	0.01	0.99	FALSE
18	GTEx	Brain Hypothalamus	TRIM65	0.26	0.09	lasso	7	0.12	9.7e-04	-5.7	-5.6	1.7e-08	0.71	0.04	0.54	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	FBF1	0.29	0.32	lasso	2	0.29	1.9e-08	-6.4	-6.3	2.2e-10	0.88	0.01	0.99	FALSE
20	GTEx	Breast Mammary Tissue	FBF1	0.15	0.20	lasso	3	0.19	6.9e-10	-7.0	-7.1	1.7e-12	1.00	0.00	1.00	FALSE
21	GTEx	Breast Mammary Tissue (Female)	FBF1	0.14	0.13	lasso	3	0.13	1.2e-04	-5.7	-6.5	1.1e-10	0.84	0.02	0.89	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	TRIM47	0.42	0.07	lasso	4	0.06	4.0e-03	-6.1	-5.7	1.0e-08	0.58	0.07	0.11	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	RP11-552F3.9	0.50	0.08	enet	10	0.11	2.4e-04	-6.1	-5.3	9.2e-08	0.59	0.10	0.15	FALSE
24	GTEx	Cells Transformed fibroblasts	FBF1	0.14	0.08	lasso	5	0.07	5.1e-06	-7.0	-5.9	3.0e-09	0.90	0.00	1.00	FALSE
25	GTEx	Colon Sigmoid	FBF1	0.38	0.10	enet	19	0.17	1.5e-06	-6.8	-5.7	1.5e-08	0.87	0.01	0.99	FALSE
26	GTEx	Colon Transverse	TRIM65	0.32	0.13	lasso	6	0.12	3.1e-06	-7.0	-5.8	4.9e-09	0.91	0.00	1.00	FALSE
27	GTEx	Colon Transverse	FBF1	0.28	0.21	lasso	3	0.19	2.8e-09	-7.0	-7.0	3.3e-12	0.98	0.00	1.00	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	FBF1	0.33	0.16	lasso	6	0.13	2.3e-05	-6.4	-6.7	1.7e-11	0.95	0.00	0.99	FALSE
29	GTEx	Esophagus Muscularis	FBF1	0.34	0.33	lasso	3	0.32	5.5e-20	-7.0	-7.1	1.6e-12	1.00	0.00	1.00	FALSE
30	GTEx	Heart Atrial Appendage	FBF1	0.20	0.11	lasso	3	0.15	2.6e-07	-7.0	-6.0	1.7e-09	0.83	0.00	0.98	FALSE
31	GTEx	Lung	UNC13D	0.12	0.09	enet	15	0.10	3.4e-08	-6.2	-6.1	1.3e-09	0.73	0.04	0.96	FALSE
32	GTEx	Lung	FBF1	0.20	0.18	lasso	1	0.17	2.6e-13	-7.0	-7.0	1.9e-12	1.00	0.00	1.00	FALSE
33	GTEx	Lung	RP11-552F3.10	0.12	0.02	lasso	2	0.03	4.4e-03	-5.3	5.5	3.2e-08	-0.51	0.03	0.22	FALSE
34	GTEx	Muscle Skeletal	FBF1	0.07	0.02	lasso	4	0.02	8.0e-03	-6.7	-6.8	9.5e-12	0.90	0.01	0.98	FALSE
35	GTEx	Nerve Tibial	TRIM65	0.25	0.10	lasso	6	0.16	8.7e-12	-4.6	-6.7	2.3e-11	0.73	0.65	0.35	FALSE
36	GTEx	Nerve Tibial	FBF1	0.54	0.46	enet	37	0.45	2.9e-35	-7.0	-6.4	2.0e-10	0.94	0.00	1.00	FALSE
37	GTEx	Nerve Tibial	MRPL38	0.14	0.10	lasso	3	0.11	2.9e-08	-6.0	6.5	8.2e-11	-0.83	0.09	0.91	FALSE
38	GTEx	Nerve Tibial	RP11-552F3.9	0.14	0.05	lasso	5	0.07	2.0e-05	-6.9	6.0	2.2e-09	-0.72	0.01	0.98	FALSE
39	GTEx	Pituitary	FBF1	0.34	0.37	lasso	4	0.39	7.6e-11	-7.0	-6.8	1.2e-11	0.98	0.00	1.00	FALSE
40	GTEx	Prostate	FBF1	0.26	0.24	lasso	1	0.20	1.2e-05	-7.0	-7.0	1.9e-12	1.00	0.00	1.00	FALSE
41	GTEx	Skin Sun Exposed Lower leg	TRIM47	0.09	0.03	lasso	3	0.03	1.5e-03	-6.9	7.2	6.2e-13	-0.89	0.01	0.99	TRUE
42	GTEx	Skin Sun Exposed Lower leg	FBF1	0.22	0.23	lasso	1	0.21	3.0e-17	-7.0	-7.0	1.9e-12	1.00	0.00	1.00	FALSE
43	GTEx	Skin Sun Exposed Lower leg	MRPL38	0.18	0.10	lasso	6	0.09	4.8e-08	-6.0	6.1	9.1e-10	-0.73	0.10	0.90	FALSE
44	GTEx	Skin Sun Exposed Lower leg	RP11-552F3.10	0.06	0.03	lasso	2	0.02	3.8e-03	-6.6	6.5	9.8e-11	-0.74	0.05	0.77	FALSE
45	GTEx	Stomach	FBF1	0.28	0.17	enet	12	0.17	1.5e-08	-7.0	-6.7	1.6e-11	0.95	0.00	1.00	FALSE
46	GTEx	Testis	FBF1	0.37	0.38	lasso	2	0.38	8.4e-18	-7.0	-7.1	1.3e-12	1.00	0.00	1.00	FALSE
47	GTEx	Thyroid	WBP2	0.07	0.06	lasso	2	0.06	4.1e-05	-4.5	-5.4	6.5e-08	0.72	0.03	0.95	FALSE
48	GTEx	Thyroid	TRIM65	0.19	0.11	lasso	2	0.09	3.5e-07	-7.0	-7.0	3.7e-12	0.97	0.00	1.00	FALSE
49	GTEx	Thyroid	FBF1	0.24	0.23	lasso	2	0.23	8.0e-18	-7.0	-6.6	4.5e-11	0.99	0.00	1.00	FALSE
50	GTEx	Thyroid	MRPL38	0.15	0.07	lasso	3	0.09	1.1e-07	-6.6	6.7	2.0e-11	-0.84	0.05	0.95	FALSE
51	METSIM	Adipose	FBF1	0.20	0.09	enet	41	0.12	2.5e-17	-7.0	-6.5	8.5e-11	0.74	0.00	1.00	FALSE
52	METSIM	Adipose	TRIM65	0.13	0.03	enet	24	0.06	1.4e-09	-6.8	-5.4	7.4e-08	0.71	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Glioblastoma Multiforme	TRIM65	0.08	0.02	enet	7	0.04	1.9e-02	-6.0	-6.7	1.7e-11	0.78	0.02	0.60	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ACOX1	0.09	0.06	enet	3	0.05	1.1e-03	-6.6	-6.3	3.2e-10	0.71	0.03	0.93	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM65	0.07	0.07	lasso	3	0.09	5.7e-10	-6.5	-6.1	1.0e-09	0.65	0.10	0.90	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM47	0.04	0.01	blup	30	0.03	2.7e-04	-5.2	5.2	2.3e-07	-0.41	0.01	0.67	FALSE
57	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C17orf106	0.22	0.14	blup	45	0.13	6.9e-06	-2.3	5.4	7.1e-08	-0.67	0.10	0.25	FALSE
58	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FBF1	0.08	0.05	blup	41	0.04	1.1e-02	-6.1	-7.1	1.4e-12	0.85	0.01	0.86	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRIM47	0.04	0.03	lasso	4	0.03	9.5e-04	-6.1	6.0	2.2e-09	-0.69	0.02	0.70	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	MRPL38	0.04	0.01	blup	29	0.03	5.0e-03	-6.3	6.1	9.0e-10	-0.64	0.03	0.35	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM47	0.06	0.06	blup	30	0.06	1.6e-06	-7.0	6.1	1.4e-09	-0.67	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM65	0.19	0.15	lasso	2	0.17	5.7e-16	-6.1	-5.8	5.7e-09	0.57	0.60	0.40	FALSE