Hub : Genes

ACOX1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0230	2.4e-02	0.000	0.003	0.017	0.015	0.001	2.8e-01	1.1e-01	3.3e-03	5.9e-03	2.5e-01
2	GTEx	Whole Blood	0.1370	0.0490	3.5e-03	0.045	NA	0.069	NA	0.079	5.1e-05	NA	6.4e-07	NA	9.9e-08
3	METSIM	Adipose	0.0544	0.0227	2.7e-03	-0.002	0.018	-0.001	0.017	-0.002	8.2e-01	7.3e-04	4.7e-01	1.1e-03	7.3e-01
4	NTR	Blood	0.0661	0.0175	1.5e-06	0.037	0.020	0.037	0.031	0.035	4.2e-12	3.4e-07	3.9e-12	2.0e-10	1.4e-11
5	YFS	Blood	0.0820	0.0180	0.0e+00	0.097	0.059	0.096	0.092	0.097	5.4e-30	1.6e-18	1.1e-29	2.1e-28	5.1e-30
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0870	0.0410	1.6e-03	0.061	0.035	0.047	NA	0.046	2.1e-04	4.3e-03	1.1e-03	NA	1.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.7	2.5	-1.2	-0.3	1.6	0.4	0.0	-0.3
Bipolar Disorder or Schizophrenia	0.8	2.1	9.0	-3.0	-0.6	1.2	0.7	0.9	-0.3
Depressed Affect (Nagel 2018)	3.3	6.9	15.0	-1.9	1.8	0.8	3.9	3.5	-2.5
Depression (Nagel 2018)	2.5	3.7	7.9	-1.9	1.7	1.3	2.8	2.1	-1.2
Intelligence (Savage-Jansen 2018)	1.2	3.5	10.2	-0.8	-0.6	-1.3	-1.3	-2.6	3.2
Neuroticism (Nagel 2018)	1.1	2.7	5.1	-0.8	1.0	1.2	2.3	2.0	-2.0
Schizophrenia (2018)	0.8	1.7	7.9	-2.8	-0.5	0.3	0.6	1.2	-0.1
Schizophrenia vs Biploar Disorder	0.8	1.1	4.3	-1.0	-0.1	-2.1	0.3	0.4	1.0
Worry (Nagel 2018)	0.8	1.8	6.2	0.9	-0.7	1.6	0.7	0.6	-2.5
Alzheimer’s Disease (in mother)	1.5	1.8	4.6	-2.2	0.8	0.7	1.6	1.4	0.7
Alzheimer’s Disease (in father)	0.9	1.0	1.5	-1.1	-1.0	1.2	-0.5	-1.0	1.1
Alzheimer’s Disease (including proxy)	1.0	1.5	5.6	-2.4	0.2	1.0	1.0	0.9	0.6
Crohns Disease (2017)	0.6	1.2	3.4	0.2	0.8	-1.8	0.1	0.8	-1.6
Irritable Bowel Disease (IBD)	0.7	1.7	3.6	1.6	-0.9	-0.9	-1.9	-1.3	-0.9
Ulcerative Colitis (UC)	1.3	2.4	5.9	1.8	-1.3	0.6	-2.4	-1.9	0.1
Major Depression (MDD)	1.9	2.3	5.8	-1.6	-0.1	2.4	2.0	1.3	-0.2
Reaction Time	0.2	0.4	0.9	0.2	0.4	-0.8	-1.0	-0.8	0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.3	3.6	-0.5	0.7	-1.4	-0.5	-1.2	1.9
Breast Cancer	0.4	1.0	3.9	0.3	0.3	-1.4	-0.1	0.4	-2.0
Ovarian Cancer	1.4	1.8	4.5	-0.2	-1.4	-1.6	-2.1	-1.5	0.1
Prostate Cancer	1.3	1.8	4.2	1.9	0.1	-1.6	0.4	0.7	-2.0
Age at First Birth	0.1	0.2	0.3	-0.5	0.6	0.3	0.5	0.4	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.3	2.7	-1.2	-1.0	1.3	-0.5	-0.9	1.6
Coronary Artery Disease (CAD)	3.3	4.0	8.7	-0.4	2.7	-0.1	2.8	3.0	0.0
Crohns Disease (2012)	1.2	2.0	7.9	0.8	0.3	-2.8	0.1	0.6	-1.7
Mean Putamen Volume	0.7	0.7	3.1	0.7	0.3	0.5	0.3	0.7	-1.8
Fasting Glucose	0.4	0.5	1.3	0.6	-0.9	-1.2	-0.2	0.2	-0.6
HbA1C	0.2	0.2	0.6	0.0	-0.8	0.1	-0.3	-0.4	-0.6
HDL Cholesterol	0.9	1.6	3.3	0.9	-0.4	0.2	-1.8	-1.7	1.5
LDL Cholesterol	1.5	2.4	8.9	3.0	0.7	1.0	0.3	0.3	-2.0
Lupus	0.6	0.9	5.2	-2.3	-0.2	-0.1	0.0	0.2	0.3
Neuroticism (2016)	1.8	2.6	5.9	-1.6	-0.3	2.4	1.5	1.2	-1.7
Primary Biliary Cirrhosis	0.8	1.1	2.0	-0.0	0.7	0.8	1.1	1.4	-1.4
Rheumatoid Arthritis	0.6	0.8	2.3	-1.3	-0.2	-0.3	0.7	0.4	1.5
Schizophrenia (2014)	0.8	1.8	7.6	-2.8	-0.3	0.4	0.7	1.4	-0.2
Triglycerides	0.4	0.7	2.0	-0.2	-0.4	1.4	0.2	0.1	-1.3
Type 2 Diabetes (T2D) (2012)	0.5	0.5	0.9	0.9	0.7	0.9	0.5	0.2	-0.7
Ulcerative Colitis	2.4	3.5	7.2	2.6	-1.3	0.2	-2.7	-2.2	0.1
Blood Eosinophil Count	0.8	6.4	24.8	3.2	0.1	-0.8	1.1	1.3	-5.0
Blood Platelet Count	0.5	5.8	17.2	4.2	-1.0	2.2	-0.5	-1.9	-2.8
Blood Red Count	0.3	2.7	6.1	-1.3	0.2	2.5	-2.3	-1.4	1.1
Blood White Count	0.4	3.2	10.4	0.7	0.7	-0.5	2.2	1.6	-3.2
Heel T-Score	0.2	1.4	4.8	-0.3	-0.1	2.2	1.5	0.5	-0.9
BMI	0.7	3.8	14.4	-2.3	0.2	1.7	0.4	0.1	3.8
Height	0.6	11.5	16.2	3.0	-3.7	1.8	-4.0	-3.3	3.9
Waist Hip Ratio (WHR)	0.9	4.1	14.3	-2.2	-1.0	1.3	0.6	1.4	-3.8
Systolic Blood Pressure	2.2	10.8	39.6	4.2	-0.2	-1.8	1.4	1.6	-6.3
Smoking Status	1.1	2.6	8.0	-2.8	-1.2	0.7	2.0	1.4	0.0
Allergy or Eczema	0.2	0.6	2.1	-0.6	-0.2	-1.5	-0.2	-0.5	0.8
Cardiovascular Disease	2.7	8.8	23.5	4.8	0.0	-1.4	1.3	1.6	-4.8
Hypothyroidism (self reported)	1.9	4.3	16.3	-4.0	-1.2	1.0	1.3	0.7	2.2
Respiratory disease	2.4	5.4	22.5	-4.7	0.5	1.3	0.0	0.0	2.9
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.4	-1.1	-0.0	-0.5	1.3	1.5	-0.7
Lung FEV1/FVC ratio	0.3	1.3	2.2	1.0	0.8	-1.1	1.5	1.2	-1.2
Lung FVC	0.6	2.9	7.3	-2.7	0.7	-1.7	0.7	0.8	2.4
Neuroticism	1.7	4.2	10.2	-0.6	1.2	1.2	2.5	2.3	-3.2
Chronotype (morning person)	1.0	2.4	11.5	3.4	-0.2	-0.9	-0.1	0.1	-1.4
Hair Pigment	0.1	2.7	7.8	2.8	-0.8	-1.2	-1.3	-1.2	-1.8
Tanning	0.1	0.9	3.6	-1.9	0.9	-0.2	-0.3	0.1	0.8
Hand grip strength (left)	1.0	2.6	13.4	1.0	-0.7	-3.7	-0.7	0.1	-0.3
Number of treatments/medications taken	0.6	1.0	2.8	-0.9	-0.0	-0.0	1.7	1.0	-1.2
Average weekly spirits intake	2.5	3.1	5.5	0.4	-1.8	0.9	-2.0	-2.3	2.2
Sensitivity / hurt feelings	1.1	2.0	3.8	-0.4	1.6	0.1	1.9	1.8	-1.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.0	-0.9	0.6	0.7	1.4	1.1	-1.4
Hearing difficulty/problems: Yes	0.2	0.3	1.1	0.3	0.1	1.1	0.5	-0.6	0.5
Relative age of first facial hair	0.3	0.7	1.2	0.8	-0.7	-0.9	0.9	1.1	-0.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.8	-0.4	-1.1	-0.9	-1.1	-1.4	1.9
Ever used hormone-replacement therapy (HRT)	1.7	2.2	4.8	-0.0	0.7	-0.8	2.2	1.6	-2.2
Ever had hysterectomy (womb removed)	1.0	1.1	2.5	-1.1	1.6	-0.1	1.0	1.3	0.4
Systolic blood pressure, automated reading	1.2	3.4	9.0	1.9	0.4	0.3	1.9	1.8	-3.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	-0.5	-0.8	-0.9	-0.1	-0.2	0.9
Angina	0.5	0.7	2.1	-1.5	0.1	0.5	1.2	0.3	0.3
Medication for hormone replacement therapy	1.5	1.7	3.3	1.1	1.2	-0.8	1.8	1.7	-0.8
Vitamin and mineral supplements	2.2	3.0	12.7	2.0	0.8	-3.6	-0.8	-0.4	-0.5
Supplements: Zinc	1.4	1.5	3.7	-1.9	0.7	1.9	0.8	1.0	-0.1
Medication: Co-codamol	0.4	0.5	1.1	-0.8	-0.2	0.0	1.0	1.1	0.0
Medication: Metformin	0.8	1.2	2.3	-1.5	0.8	0.2	1.4	1.5	-0.1
Diabetes (father)	0.7	0.9	1.3	-0.9	1.1	-0.8	0.9	1.1	-0.8
Diabetes (mother)	0.2	0.3	0.8	-0.9	-0.3	0.9	-0.3	-0.0	0.2
Severe depression (siblings)	1.4	1.6	4.6	-1.6	-0.8	-0.7	-0.7	-0.8	2.1
Pack years adult smoking proportion	2.0	3.0	8.8	-3.0	-1.5	1.4	-1.2	-0.5	1.8
Impedance of leg (right)	0.2	1.0	3.5	0.2	-0.6	1.2	0.8	0.0	-1.9
Leg fat-free mass (left)	1.0	5.2	13.9	0.4	-1.8	1.4	-2.7	-2.2	3.7
Trunk fat percentage	1.4	5.7	15.1	-1.1	-0.6	3.9	-0.6	-1.5	3.9
Hand grip strength (right)	0.7	2.0	10.2	-0.0	-1.1	-3.2	-0.7	0.0	0.2
Townsend deprivation index at recruitment	0.8	1.2	6.0	-0.7	0.2	2.5	-0.0	0.4	-0.6
Current tobacco smoking	0.7	1.2	2.6	-1.2	-0.6	0.8	1.6	1.5	-0.2
Average weekly fortified wine intake	1.1	1.3	4.7	-2.2	0.6	-1.1	0.1	-0.2	1.1
Maternal smoking around birth	1.3	1.9	4.7	-1.2	-1.8	-0.2	-1.2	-1.0	2.2
Fed-up feelings	3.7	6.7	11.7	-2.7	1.7	0.9	3.4	3.4	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.4	-1.4	0.5	0.8	1.6	1.4	-0.9
Relative age voice broke	0.2	0.3	0.6	-0.1	0.4	-0.8	0.7	0.7	-0.3
Taking other prescription medications	0.9	1.3	3.8	-1.9	0.4	-0.7	1.6	0.9	0.2
Age when periods started (menarche)	0.2	0.4	1.6	-1.3	-0.2	-0.2	-0.0	-0.2	0.8
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	1.9	-0.4	1.4	-1.1	1.2	1.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.3	0.1	-1.1	-0.2	0.5	-0.0	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	-0.7	0.1	-0.8	0.2	0.0	0.4
Qualifications: CSEs or equivalent	0.4	0.5	1.1	0.8	-0.7	0.1	-0.8	0.2	-1.0
Serious illness, injury or assault to yourself	0.8	1.0	3.3	-1.8	0.2	-1.1	-0.0	0.0	1.2
High blood pressure	2.7	7.4	19.4	4.3	0.3	-1.9	1.1	1.1	-4.4
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.9	-0.6	-0.1	-1.6	-0.3	-0.7	1.7
Multivitamins +/- minerals	1.1	1.4	4.6	-0.7	-1.3	2.1	-0.3	-0.7	1.0
Stomach or abdominal pain in last month	1.0	1.3	5.5	0.9	-0.9	-2.3	0.5	0.3	-0.2
Supplements: Glucosamine	0.4	0.5	2.3	-0.5	-0.7	1.5	-0.3	0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.7	0.3	-0.9	0.0	0.1	-0.1	-0.3
Medication: Atenolol	4.3	5.3	16.6	1.0	1.1	1.4	2.5	2.3	-4.1
Medication: Levothyroxine sodium	2.1	3.6	12.6	-3.6	-0.8	0.7	2.2	1.7	0.7
Sitting height	0.5	3.4	7.0	1.8	-2.0	1.3	-2.6	-2.0	0.6
Chronic bronchitis/emphysema (father)	2.1	2.5	3.6	-1.5	1.9	1.6	1.9	1.6	-0.3
High blood pressure (mother)	2.2	3.1	10.3	3.2	0.1	-0.6	0.1	0.2	-2.8
Body mass index (BMI)	0.6	2.4	11.3	-1.3	-0.0	1.1	-0.1	-0.6	3.4
Impedance of leg (left)	0.3	1.5	5.2	-0.2	-0.2	1.2	1.4	0.6	-2.3
Leg predicted mass (left)	1.0	5.3	14.1	0.4	-1.8	1.5	-2.7	-2.2	3.8
Trunk fat mass	1.4	6.0	17.6	-1.0	-1.2	3.4	-1.2	-1.8	4.2
Waist circumference	0.9	3.4	7.2	-2.5	-0.9	2.7	-0.3	-0.5	2.4
Number of incorrect matches in round	0.6	0.9	3.4	0.8	-0.2	1.1	0.0	0.6	-1.8
Past tobacco smoking	0.5	0.9	2.9	1.4	1.7	0.0	0.2	0.7	0.3
Alcohol usually taken with meals	0.7	1.2	2.5	0.5	1.6	-1.3	0.2	1.2	-1.1
Nervous feelings	0.8	1.5	4.7	1.2	-1.6	0.3	-0.8	-0.1	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	0.3	0.6	0.3	0.6	0.6	-0.7
Hearing difficulty/problems with background noise	0.8	1.3	2.1	-1.1	1.5	1.4	0.9	1.0	0.6
Hair/balding pattern: Pattern 2	0.3	0.3	1.7	-1.3	-0.3	-0.1	0.0	0.4	-0.1
Had menopause	0.2	0.3	1.1	-0.6	-0.5	1.1	-0.0	-0.1	0.1
Had other major operations	1.3	1.6	3.5	0.3	1.1	1.9	1.4	1.2	-1.1
Forced vital capacity (FVC)	0.9	3.6	8.9	-0.1	-1.4	-1.2	-2.3	-2.0	3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.1	-0.0	-1.0	0.4	0.6	0.4	-0.1
Ever unenthusiastic/disinterested for a whole week	3.1	3.8	6.6	-1.4	2.3	0.2	2.3	1.9	-2.6
Qualifications: None of the above	0.2	0.5	2.1	-0.2	0.5	1.5	0.5	0.3	-0.6
Financial difficulties in last 2 years	0.6	0.8	2.1	-1.2	1.0	0.3	0.6	0.2	1.4
Mouth/teeth dental problems	1.3	2.0	2.5	1.6	-1.4	0.7	-1.6	-1.6	1.4
Heart attack	1.1	1.4	5.9	0.2	0.2	-0.2	1.3	0.8	-2.4
Allergy	1.4	3.3	9.4	2.7	1.0	0.6	0.9	1.0	-3.1
Pain all over the body in last month	2.1	2.2	6.2	-2.5	0.4	0.8	1.6	1.8	0.7
Diabetes (self-reported)	0.5	0.8	2.2	-1.5	0.4	-0.6	1.1	1.1	0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.5	-1.6	-0.6	-0.6	-0.1	-0.0	-0.0
Medication: Ramipril	2.7	3.5	7.8	2.8	-0.5	-2.2	-1.7	-2.1	-0.7
Medication: Simvastatin	2.7	4.0	13.6	2.7	0.4	-1.1	0.6	1.1	-3.7
Fluid intelligence score	0.4	0.9	3.6	-0.2	0.8	-0.5	-0.4	-0.7	1.9
Illnesses of siblings	3.3	4.7	11.5	-0.5	-2.0	0.9	-2.4	-2.4	3.4
Neuroticism score	1.5	3.0	10.1	-0.6	0.9	0.7	1.7	1.8	-3.2
Weight	1.0	4.7	15.6	-0.4	-1.5	2.2	-1.6	-1.7	4.0
Impedance of arm (right)	0.2	1.0	5.8	0.5	0.4	2.4	0.0	-0.3	-0.1
Arm fat percentage (right)	1.0	4.1	14.6	-1.4	0.3	2.8	0.1	-0.6	3.8
Trunk fat-free mass	0.6	3.5	6.6	0.8	-2.5	0.1	-2.6	-1.9	2.0
Hip circumference	1.6	7.1	23.4	-0.9	-1.8	2.4	-1.9	-2.4	4.8
Time employed in main current job	0.6	0.6	1.5	-1.0	-0.6	1.2	0.3	0.1	1.0
Alcohol intake versus 10 years previously	2.8	4.2	10.9	2.1	1.1	1.6	1.5	2.0	-3.3
Father’s age at death	0.4	0.5	1.0	-1.0	0.3	-0.4	-1.0	-0.7	0.6
Worrier / anxious feelings	0.9	1.7	5.9	-0.2	-0.4	1.5	0.8	1.0	-2.4
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	5.5	-2.3	1.9	-0.3	2.3	1.7	-1.1
Falls in the last year	0.2	0.3	1.0	-0.3	1.0	0.0	0.6	0.6	0.5
Hair/balding pattern: Pattern 3	0.5	0.7	2.4	1.0	1.6	0.2	0.6	-0.0	0.6
Number of live births	0.7	1.0	3.2	0.2	0.2	-0.0	-1.4	-0.8	1.8
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	7.8	-0.7	-0.9	-1.4	-1.7	-1.5	2.8
Pulse rate	1.2	2.1	7.7	0.7	0.8	-2.8	0.9	1.6	-0.3
Happiness	4.3	5.3	10.6	-2.0	1.7	0.6	3.2	3.2	-1.9
Noisy workplace	0.9	1.2	4.2	0.9	-1.3	-2.1	0.1	0.1	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.6	-0.0	1.3	-0.7	0.1	0.3	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.5	-0.2	0.2	-0.3	-0.9	-0.8	1.6
Mouth/teeth dental problems: Dentures	0.9	1.5	2.7	-1.6	1.1	-0.2	1.5	1.3	-0.9
Asthma	1.7	3.4	12.7	-3.6	1.1	-0.2	-0.0	0.1	2.5
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.8	9.6	-1.4	1.8	-0.0	3.1	2.7	-1.0
Medication: Cholesterol lowering	1.2	1.8	6.4	1.4	-0.9	-1.3	0.0	-0.1	-2.5
Depression (self-reported)	0.8	1.0	2.4	-1.5	0.7	0.7	1.3	0.9	-0.2
Medication: Lansoprazole	0.6	0.7	2.9	-0.1	-0.6	-1.7	-0.2	-0.1	0.8
Prospective memory result	1.5	1.9	6.0	1.1	-0.3	1.4	0.7	1.3	-2.4
Lung cancer (father)	0.2	0.3	0.4	-0.6	-0.5	0.5	0.6	0.6	-0.5
Illnesses of mother	0.5	0.6	2.5	-0.6	-0.4	-0.4	0.2	-0.3	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	6.7	-0.3	-0.7	-0.6	-1.6	-1.6	2.6
Pulse wave Arterial Stiffness index	0.3	0.3	0.5	-0.7	-0.6	-0.7	0.2	0.6	-0.4
Impedance of arm (left)	0.4	1.8	9.2	0.9	-0.1	3.0	-0.3	-0.8	0.3
Arm fat mass (right)	1.0	4.2	16.5	-0.5	-0.5	2.3	-0.9	-1.4	4.1
Trunk predicted mass	0.6	3.3	6.2	0.8	-2.4	0.1	-2.5	-1.8	1.9
Standing height	0.8	7.7	13.1	2.2	-3.5	2.4	-3.6	-2.8	1.5
Length of working week for main job	0.2	0.2	0.4	-0.2	-0.3	-0.5	-0.6	-0.6	0.6
Exposure to tobacco smoke at home	0.8	0.9	4.1	0.6	-2.0	0.4	-0.3	-1.0	-0.3
Breastfed as a baby	0.9	1.1	4.5	-0.6	-0.4	2.1	-0.4	-0.6	-0.9
Tense / ‘highly strung’	0.4	0.7	2.8	-1.7	-0.3	0.3	0.3	0.6	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	9.8	-3.1	-1.0	0.3	0.1	0.4	0.6
Hair/balding pattern: Pattern 4	1.0	2.5	11.8	1.1	-0.2	1.1	0.7	0.4	-3.4
Birth weight of first child	0.4	0.7	1.8	0.9	0.6	1.3	0.3	0.6	-1.0
Peak expiratory flow (PEF)	1.0	2.2	4.2	-1.2	-0.9	-2.0	-1.3	-1.2	1.9
Pulse wave reflection index	0.1	0.1	0.2	-0.2	-0.5	0.5	-0.1	-0.4	0.1
Ever highly irritable/argumentative for 2 days	1.3	1.6	4.0	-2.0	1.7	-0.4	1.5	0.8	-0.1
Loud music exposure frequency	1.8	2.0	5.1	0.6	0.3	-2.3	1.5	1.3	-1.4
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.0	1.1	-0.5	-1.7	-1.7	-1.7	1.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	-0.8	0.4	-0.9	0.2	0.1	-0.4
Blood clot in the leg (DVT)	0.5	0.7	1.7	-1.3	-0.7	0.0	0.1	0.4	1.3
Medication: Paracetamol	0.8	1.4	5.2	-0.4	-0.4	2.3	1.4	0.6	-0.6
Headache pain in last month	0.3	0.6	2.0	0.8	0.7	1.4	0.3	-0.1	0.3
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	11.0	-1.9	1.3	1.2	-0.3	-0.3	3.3
Glaucoma (self-reported)	0.5	0.5	1.6	0.6	0.8	-0.1	0.3	0.7	-1.3
Gout (self-reported)	0.3	0.4	1.4	-1.2	-0.1	0.9	-0.2	0.1	0.2
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	11.1	-3.3	-1.4	0.5	1.2	0.8	1.7
Medication: Amlodipine	5.3	7.4	17.7	-0.1	2.2	-0.9	3.1	3.4	-4.2
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.6	-0.8	-0.1	0.2	-0.6	-0.9	1.6
Birth weight	0.3	0.6	1.8	-1.0	-1.3	0.0	-0.7	-0.5	0.5
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.9	0.3	-1.7	0.2	-0.9	-1.4	0.9
High blood pressure (siblings)	3.5	5.1	14.3	0.8	2.3	-0.7	2.3	2.1	-3.8
Forced vital capacity (FVC), Best measure	0.7	2.4	5.6	0.3	-1.0	-0.8	-2.0	-1.9	2.4
Body fat percentage	1.3	5.2	15.2	-1.5	-0.5	3.4	-0.2	-1.2	3.9
Leg fat percentage (right)	1.0	3.7	11.4	-1.9	-0.6	2.5	0.4	-0.8	3.4
Arm fat-free mass (right)	0.8	4.0	7.7	-0.1	-2.4	0.7	-2.4	-2.0	2.8
Exposure to tobacco smoke outside home	0.7	0.9	1.8	-1.4	0.7	1.1	0.8	1.0	-0.7
Comparative body size at age 10	0.8	2.2	12.1	0.6	-0.4	-3.5	-0.8	-0.0	0.2
Number of full brothers	0.4	0.5	1.3	0.5	0.1	0.6	-0.4	-1.1	0.9
Worry too long after embarrassment	0.7	1.2	2.6	0.2	-0.6	0.9	-1.6	-1.5	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.5	-1.6	0.6	1.4	1.0	1.0	0.4
Wheeze or whistling in the chest in last year	1.5	2.6	13.8	-3.7	-0.7	-0.0	-0.0	0.2	1.1
Number of children fathered	0.5	0.6	1.0	-0.7	-0.9	-0.7	-0.2	-0.8	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.4	0.8	-0.5	0.2	-0.1	0.0	-1.5
Age at first live birth	0.5	0.9	1.7	-1.2	-0.7	0.6	-1.0	-1.3	-0.2
Pulse wave peak to peak time	0.5	0.6	0.9	1.0	0.3	0.9	-0.7	-0.9	0.3
Health satisfaction	2.1	2.7	9.3	-3.1	-0.7	-0.1	2.1	1.1	-0.8
Shortness of breath walking on level ground	0.6	0.7	2.2	-1.5	0.4	0.7	0.9	0.7	-0.4
Qualifications: College or University degree	0.1	0.5	1.9	1.4	-0.3	0.4	-0.5	-0.1	0.7
Eye problems/disorders: None of the above	0.5	0.6	1.3	-0.6	-0.3	0.4	-0.9	-0.8	1.1
Mouth/teeth dental problems: Loose teeth	2.3	2.8	6.2	-2.1	0.5	0.0	2.1	2.5	-1.1
Emphysema/chronic bronchitis	2.8	3.1	4.5	-1.8	-2.1	1.3	-1.7	-1.5	2.1
Medication for pain relief, constipation, heartburn	2.1	3.7	9.9	0.6	-1.6	-0.6	-3.1	-2.4	1.7
Neck or shoulder pain in last month	0.9	1.3	3.0	0.7	0.8	-0.9	1.4	1.7	-1.0
Medication: Blood pressure	1.6	2.9	12.3	1.5	-0.9	-1.1	0.5	0.5	-3.5
Angina (self-reported)	0.5	0.7	1.8	-1.3	0.4	0.4	1.4	0.4	0.2
Migraine (self-reported)	2.4	3.0	4.9	0.4	-1.9	2.1	-2.2	-2.2	0.5
Medication: Ibuprofen	2.8	3.4	8.2	-2.2	1.5	-0.1	2.9	2.2	-0.4
Medication: Allopurinol	0.9	1.2	4.6	0.6	-0.5	2.1	-1.3	-0.6	-0.3
Medication: Omeprazole	1.0	1.2	3.5	-0.1	1.0	1.3	1.9	0.9	0.1
Medication: Seretide 50 evohaler	1.2	1.3	5.4	-2.3	0.1	0.3	0.9	0.3	1.2
Mean time to correctly identify matches	0.2	0.4	1.0	0.7	1.0	-0.5	-0.3	-0.4	-0.3
Heart disease (mother)	0.9	1.1	2.5	1.4	1.6	-0.2	0.8	0.8	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	4.7	1.2	-1.5	-1.0	-1.6	-2.2	1.9
Whole body fat mass	1.2	5.0	15.6	-0.8	-1.1	3.0	-1.0	-1.6	3.9
Leg fat mass (right)	1.3	4.8	16.9	-1.5	-1.1	2.6	-0.5	-1.3	4.1
Arm predicted mass (right)	0.7	3.7	8.5	-0.1	-2.2	0.6	-2.2	-1.9	2.9
Pulse rate, automated reading	0.4	1.3	4.5	0.9	-0.2	-0.6	1.4	2.1	-0.3
Alcohol intake frequency.	0.9	2.2	7.9	2.2	0.5	0.3	-0.3	0.0	-2.8
Comparative height size at age 10	1.0	5.3	10.2	1.4	-2.8	1.9	-3.2	-2.3	1.6
Number of full sisters	0.5	0.6	2.1	-1.4	0.1	0.9	0.4	0.0	0.7
Suffer from ‘nerves’	1.0	1.6	7.2	1.1	-0.8	0.1	0.6	0.5	-2.7
Overall health rating	3.3	7.1	13.2	-2.0	1.1	0.2	3.6	3.6	-3.3
Chest pain or discomfort	0.5	0.7	3.6	0.5	-0.6	-1.9	0.0	-0.2	-0.2
Had major operations	0.4	0.5	1.1	0.4	0.9	-1.1	0.3	0.9	-0.1
Age at last live birth	1.3	1.9	4.1	-1.1	-1.3	-0.0	-1.9	-2.0	0.5
Family relationship satisfaction	0.6	0.7	1.7	-0.5	-1.3	-1.3	0.1	0.1	-0.9
Leg pain on walking	2.0	2.5	5.2	0.3	0.6	0.2	2.1	2.2	-2.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.3	-0.3	0.7	-1.5	0.2	-0.0	-1.1
Commuting to job workplace: Car/motor vehicle	1.8	2.1	4.4	-1.4	0.2	2.1	1.6	1.0	1.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	1.3	0.1	-0.6	0.3	0.4	-1.0
Medication: Aspirin	0.8	1.1	2.9	0.1	0.6	-1.0	1.1	1.0	-1.7
Supplements: Vitamin C	1.5	1.7	5.7	-1.2	1.0	2.4	0.7	1.1	-0.8
Knee pain experienced in last month	1.3	2.0	4.0	0.7	0.8	-0.4	2.0	1.8	-1.9
Hypertension (Self-reported)	2.6	7.1	19.3	4.2	0.2	-1.6	1.3	1.2	-4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	-1.2	-0.3	0.8	0.3	-0.6	0.7
Illnesses of father: Heart disease	0.9	1.3	1.8	1.3	0.6	-0.9	1.2	1.1	-1.4
Illnesses of siblings: Diabetes	1.3	1.6	3.2	-0.5	1.7	-0.7	1.8	1.7	-0.2
Smoking status: Previous	0.7	1.0	3.5	-1.3	-1.9	-0.0	-0.6	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.1	10.6	1.8	-2.9	1.4	-3.3	-3.1	1.7
Whole body fat-free mass	0.7	4.0	7.5	0.6	-2.2	0.6	-2.6	-2.0	2.7
Leg fat-free mass (right)	0.8	4.3	11.7	0.3	-1.6	1.0	-2.6	-2.0	3.4
Arm fat percentage (left)	1.2	5.0	17.2	-1.3	-0.2	3.1	-0.3	-1.1	4.2
Average weekly red wine intake	1.6	2.4	6.2	0.3	-0.5	-1.2	-2.1	-1.4	2.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.1	-1.5	0.0	0.3	0.3	0.2	-0.6
Mood swings	1.7	3.1	4.7	-2.2	1.1	1.0	2.1	2.0	-1.7
Loneliness, isolation	3.0	4.1	8.7	-0.4	1.5	-0.2	2.6	2.7	-2.9
Long-standing illness, disability or infirmity	0.5	0.7	2.5	-1.6	0.1	-0.3	0.7	0.7	0.9
Ever had bowel cancer screening	1.0	1.1	2.0	0.0	-1.0	1.1	1.0	1.3	-1.4
Diabetes diagnosed by doctor	0.3	0.5	1.5	-1.2	0.3	0.1	0.8	0.9	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.4	-1.5	0.6	0.4	0.6	0.5	0.2
Friendships satisfaction	0.1	0.2	0.8	0.0	-0.9	-0.5	0.1	-0.1	0.0
Qualifications: nursing, teaching	0.6	0.9	2.9	-1.7	0.1	0.7	0.1	-0.5	1.3
Commuting to job workplace: Walk	2.8	3.0	7.3	0.8	1.0	-2.3	0.7	1.8	-2.7
Eye problems/disorders: Cataract	1.5	1.8	3.3	-1.0	0.9	-1.4	1.1	1.6	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.2	-0.9	0.9	-0.0	0.6	0.8	-1.1
Medication for cholesterol	3.0	4.5	8.0	-2.8	-1.5	0.5	-2.1	-2.1	2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	5.0	-1.7	1.8	0.3	2.1	2.2	-0.5
Back pain experienced in last month	0.3	0.4	1.6	-1.3	-1.0	-0.2	-0.0	-0.1	-0.2
Mineral and other dietary supplements	0.8	1.0	4.5	0.4	0.8	-2.1	-0.1	-0.5	0.8
Breast cancer (self-reported)	2.4	2.9	5.9	2.4	-0.3	1.3	-2.2	-2.1	0.6
Asthma (self-reported)	1.8	3.5	12.7	-3.6	0.8	-0.2	-0.4	-0.2	2.8
Osteoporosis (self-reported)	0.8	1.0	2.4	-0.2	1.5	1.4	0.3	-0.8	0.8
Osteoarthritis (self-reported)	2.4	3.2	4.6	-1.1	0.5	2.0	2.1	2.1	-2.1
Medication: Aspirin	1.0	1.3	2.6	0.1	1.2	-1.1	1.1	1.1	-1.6
Medication: Gliclazide	0.4	0.5	1.6	-0.1	-0.2	-1.3	0.4	0.9	-0.5
Illnesses of father: None of the above (group 1)	2.1	2.6	5.1	-0.5	-2.0	-1.2	-2.2	-2.0	0.8
Smoking status: Current	0.8	1.2	3.3	-0.8	-0.5	0.2	1.8	1.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	4.9	-1.2	-0.4	-0.5	-1.4	-1.5	2.2
Whole body water mass	0.7	3.8	7.1	0.7	-2.1	0.5	-2.5	-2.0	2.7
Leg predicted mass (right)	0.8	4.5	11.9	0.3	-1.6	0.9	-2.6	-2.1	3.5
Arm fat mass (left)	1.2	4.8	17.8	-0.7	-0.6	2.6	-1.1	-1.5	4.2
Number of self-reported non-cancer illnesses	0.5	0.9	3.0	-0.3	0.2	-0.6	1.0	1.1	-1.7
Average weekly champagne plus white wine intake	0.4	0.5	2.4	0.4	-1.5	0.3	-0.7	-0.3	0.3
Miserableness	1.4	2.4	7.8	-2.8	0.2	-1.3	1.3	1.5	-1.1
Guilty feelings	0.2	0.4	0.8	0.9	-0.1	-0.7	-0.2	-0.3	-0.8
Wears glasses or contact lenses	0.4	0.5	1.1	-0.7	-0.6	0.2	0.8	1.1	-0.7
Ever taken oral contraceptive pill	1.7	1.9	4.7	-1.0	0.6	-2.2	1.3	1.6	0.7
Hearing aid user	0.1	0.1	0.3	-0.1	0.2	0.2	0.5	0.1	0.5
Mother’s age at death	1.1	1.4	2.4	1.2	-1.2	-0.9	-1.4	-1.6	0.5
Financial situation satisfaction	1.8	2.2	4.4	-2.0	0.6	1.1	2.1	1.3	-1.3
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.6	0.3	-0.8	0.2	-0.9	-1.3	1.9
Commuting to job workplace: Public transport	0.4	0.4	0.8	-0.0	-0.8	0.3	-0.9	-0.9	-0.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.6	1.2	0.1	-0.1	-0.0	0.2	-1.3
Medication: Blood pressure	1.6	3.0	9.9	3.1	1.2	-0.2	1.2	0.7	-2.2
Pain type(s) experienced in last month: Hip pain	2.0	2.5	6.5	-0.3	1.2	0.7	2.1	2.6	-1.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	0.5	-1.2	0.4	-0.0	0.4	-0.4
High cholesterol (Self-reported)	4.4	7.8	25.2	3.8	0.9	0.2	1.3	2.3	-5.0
Medication: Bendroflumethiazide	1.9	2.8	7.9	0.0	1.4	1.9	1.5	1.2	-2.8
Medication: Paracetamol	1.5	2.3	6.5	-0.9	0.5	1.6	2.6	1.6	-1.0
Medication: Lisinopril	0.7	0.8	3.9	0.5	-0.4	-0.7	0.2	0.5	-2.0
Medication: Atorvastatin	0.9	1.1	3.7	-0.1	0.0	-0.6	1.2	1.1	-1.9
Illnesses of father: High blood pressure	1.5	1.8	4.7	0.6	1.6	-0.1	2.2	1.4	-1.1
Alcohol drinker status: Never	0.6	0.8	2.6	-0.2	0.0	-1.6	-1.1	-0.7	0.5
Ever smoked	0.4	0.6	1.2	-1.1	-1.0	1.0	-0.2	-0.6	-0.3
Basal metabolic rate	0.8	4.5	10.1	0.6	-2.1	0.8	-2.6	-2.1	3.2
Leg fat percentage (left)	1.0	3.8	9.9	-2.3	-0.2	2.5	0.9	-0.3	3.1
Arm fat-free mass (left)	0.5	2.5	5.8	0.5	-1.5	0.5	-2.0	-1.6	2.4
Number of operations (self-reported)	1.0	1.5	2.8	0.6	1.6	-0.3	1.7	1.6	0.8
Average weekly beer plus cider intake	2.4	3.4	9.7	-1.2	1.6	3.1	1.9	1.5	-1.0
Irritability	1.4	2.3	4.4	-1.9	1.5	-0.8	2.1	1.5	-0.8
Risk taking	0.7	1.0	3.8	-0.7	-0.5	2.0	0.1	-0.2	1.1
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.7	0.7	-0.7	-1.6	-0.6	-1.1	0.4
Fractured/broken bones in last 5 years	0.5	0.7	3.0	-1.7	-0.2	-0.5	0.0	0.3	0.9
Age started oral contraceptive pill	0.7	0.9	1.9	-0.8	0.5	1.1	1.2	1.4	0.3
Diastolic blood pressure, automated reading	0.9	2.8	7.5	2.7	-1.0	1.2	1.1	1.2	-2.1
Ever depressed for a whole week	1.9	2.3	4.2	-1.5	1.2	-0.5	1.8	2.0	-1.7
Unable to work because of sickness or disability	1.1	1.4	3.7	-1.9	-0.7	-0.1	1.2	1.4	0.9
Commuting to job workplace: Cycle	0.5	0.7	1.6	0.5	-0.6	-0.4	-1.0	-1.3	0.7
Myopia	0.3	0.4	1.2	-1.1	0.8	-0.0	0.4	0.2	-0.5
Vascular/heart problems diagnosed by doctor	2.2	6.1	16.3	-3.9	-0.1	1.7	-1.0	-0.9	4.0
Cholesterol lowering medication	3.0	4.4	9.9	2.4	1.5	0.5	1.8	2.2	-3.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-0.2	0.6	0.7	1.1	0.3	0.3
Pain experienced in last month	0.4	0.7	1.9	0.3	0.1	-0.0	-1.0	-1.1	1.4
Supplements: Calcium	3.9	4.3	8.3	-0.2	-2.4	1.4	-2.7	-2.9	1.6
Basal cell carcinoma (self-reported)	1.0	1.2	1.8	1.4	-1.1	-1.2	-0.7	-1.2	0.9
Heart attack/myocardial infarction (self-reported)	1.2	1.6	6.5	0.5	0.2	-0.2	1.4	0.9	-2.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.3	-1.5	-0.5	-0.1	0.3	0.5	1.3
Heart disease (siblings)	1.9	2.4	6.5	1.0	1.2	0.1	1.8	1.5	-2.5
Alcohol drinker status: Previous	0.7	0.8	3.0	0.0	0.0	1.7	0.1	0.5	-1.3
Pack years of smoking	1.9	2.8	8.8	-3.0	-1.6	1.4	-1.1	-0.5	1.6
Impedance of whole body	0.2	1.2	5.9	0.5	-0.5	2.4	-0.0	-0.7	-0.6
Leg fat mass (left)	1.2	4.7	15.9	-1.8	-0.9	2.6	-0.3	-1.1	4.0
Arm predicted mass (left)	0.5	2.4	5.8	0.5	-1.6	0.8	-1.8	-1.5	2.4