[Hub]/) : Traits : Systolic Blood Pressure :

chr1:226,488,826-229,344,237

Best TWAS P=6.63e-15 · Best GWAS P=3.19e-20 conditioned to 6.42e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex OBSCN 0.14 0.15 enet 15 0.18 7.2e-21 -6.7 5.7 1.6e-08 -0.57 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous RP5-1139B12.2 0.08 0.02 enet 17 0.03 2.2e-03 -2.8 -5.4 6.7e-08 0.66 0.18 0.19 FALSE
3 GTEx Artery Tibial RP5-1139B12.2 0.09 0.05 lasso 5 0.05 4.5e-05 -5.8 -5.5 3.7e-08 0.76 0.37 0.60 FALSE
4 GTEx Brain Cortex OBSCN 0.26 0.04 lasso 10 0.12 4.5e-04 2.5 5.3 1.1e-07 -0.24 0.09 0.05 FALSE
5 GTEx Cells Transformed fibroblasts OBSCN 0.28 0.35 lasso 9 0.37 2.0e-29 -6.8 6.9 4.9e-12 -0.71 1.00 0.00 FALSE
6 GTEx Cells Transformed fibroblasts RP5-1139B12.2 0.29 0.32 enet 25 0.35 2.3e-27 -6.8 7.7 1.1e-14 -0.77 1.00 0.00 FALSE
7 GTEx Cells Transformed fibroblasts RP5-1139B12.3 0.28 0.31 lasso 10 0.33 8.4e-26 -6.8 7.5 9.5e-14 -0.72 1.00 0.00 FALSE
8 GTEx Colon Sigmoid IBA57 0.17 0.20 lasso 1 0.19 2.4e-07 -6.1 -6.1 8.5e-10 0.67 0.90 0.02 FALSE
9 GTEx Esophagus Mucosa SNAP47 0.17 0.02 enet 43 0.08 5.2e-06 3.0 7.1 1.1e-12 -0.26 0.59 0.17 FALSE
10 GTEx Esophagus Mucosa OBSCN 0.30 0.37 lasso 5 0.37 5.1e-26 -6.8 -6.9 6.5e-12 0.71 1.00 0.00 FALSE
11 GTEx Esophagus Mucosa RP5-1139B12.2 0.08 0.04 lasso 3 0.03 2.6e-03 -6.1 -6.4 1.3e-10 0.69 0.20 0.60 FALSE
12 GTEx Esophagus Muscularis MRPL55 0.06 0.05 lasso 3 0.04 2.2e-03 -6.7 6.9 5.1e-12 -0.76 0.27 0.32 FALSE
13 GTEx Lung IBA57 0.06 0.08 lasso 1 0.06 2.0e-05 -6.2 -6.2 7.0e-10 0.67 0.94 0.01 FALSE
14 GTEx Muscle Skeletal CDC42BPA 0.12 0.06 enet 28 0.11 8.2e-11 -2.0 -5.3 1.2e-07 0.05 0.04 0.96 FALSE
15 GTEx Muscle Skeletal RP5-1087E8.3 0.06 0.05 lasso 4 0.06 1.4e-06 5.9 -5.6 1.9e-08 0.01 0.02 0.98 TRUE
16 GTEx Nerve Tibial SNAP47 0.06 0.01 enet 16 0.03 6.5e-03 -3.0 7.0 2.9e-12 -0.45 0.10 0.71 FALSE
17 GTEx Nerve Tibial MRPL55 0.08 0.06 enet 10 0.03 2.4e-03 -5.1 6.2 7.1e-10 -0.75 0.64 0.29 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic OBSCN 0.41 0.31 lasso 8 0.28 5.9e-16 -6.9 -7.0 3.5e-12 0.72 1.00 0.00 FALSE
19 GTEx Skin Not Sun Exposed Suprapubic RP5-1139B12.2 0.18 0.12 lasso 4 0.12 2.3e-07 -6.9 -7.0 1.9e-12 0.74 0.99 0.00 FALSE
20 GTEx Skin Sun Exposed Lower leg OBSCN 0.38 0.21 lasso 6 0.25 1.8e-20 -6.1 -6.8 1.2e-11 0.73 1.00 0.00 FALSE
21 GTEx Skin Sun Exposed Lower leg HIST3H2A 0.05 0.03 lasso 4 0.03 2.4e-03 -6.7 -6.7 2.6e-11 0.69 0.09 0.82 FALSE
22 GTEx Skin Sun Exposed Lower leg RP5-1139B12.2 0.07 0.04 enet 8 0.04 3.9e-04 -6.1 -6.4 1.4e-10 0.64 0.88 0.02 FALSE
23 GTEx Testis SNAP47 0.23 0.21 enet 15 0.21 7.5e-10 -4.8 5.6 1.8e-08 -0.13 1.00 0.00 FALSE
24 GTEx Thyroid MRPL55 0.07 0.02 lasso 3 0.03 4.2e-03 -6.1 5.2 2.0e-07 -0.53 0.18 0.14 FALSE
25 GTEx Whole Blood IBA57 0.07 0.02 enet 12 0.03 3.8e-04 -6.9 -7.8 6.6e-15 0.64 0.19 0.71 TRUE
26 NTR Blood HIST3H3 0.01 0.00 bslmm 359 0.01 3.5e-03 1.6 5.4 6.8e-08 -0.45 0.18 0.12 FALSE
27 YFS Blood OBSCN 0.03 0.03 lasso 3 0.03 3.7e-10 -6.1 -6.2 5.3e-10 0.73 1.00 0.00 FALSE
28 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma OBSCN 0.07 0.09 blup 96 0.10 2.8e-11 -6.8 -6.7 2.7e-11 0.71 0.02 0.98 FALSE
29 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C1orf69 0.05 0.02 blup 30 0.03 7.3e-03 -6.9 7.4 1.5e-13 -0.74 0.01 0.77 FALSE
30 The Cancer Genome Atlas Brain Lower Grade Glioma MRPL55 0.04 0.06 lasso 1 0.06 2.4e-07 -5.2 5.2 2.2e-07 -0.65 0.14 0.84 FALSE
31 The Cancer Genome Atlas Brain Lower Grade Glioma SNAP47 0.08 0.06 blup 54 0.08 1.2e-09 -4.8 6.1 9.9e-10 -0.03 0.03 0.96 FALSE
32 The Cancer Genome Atlas Lung Adenocarcinoma ARF1 0.04 0.02 lasso 2 0.01 1.3e-02 -5.0 5.3 9.1e-08 -0.72 0.03 0.19 FALSE
33 The Cancer Genome Atlas Lung Squamous Cell Carcinoma OBSCN 0.08 0.06 lasso 3 0.06 2.7e-07 -6.7 -7.0 2.3e-12 0.70 0.03 0.97 FALSE