Hub : Genes

IBA57

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.1680 0.0800 0.00760 0.037 NA 0.006 NA -0.006 4.1e-02 NA 2.2e-01 NA 4.7e-01
2 GTEx Brain Cortex 0.1310 0.0580 0.00670 0.060 NA -0.003 NA 0.051 9.8e-03 NA 4.1e-01 NA 1.6e-02
3 GTEx Colon Sigmoid 0.1730 0.0810 0.00280 0.202 NA 0.168 NA 0.192 1.1e-07 NA 1.5e-06 NA 2.4e-07
4 GTEx Esophagus Mucosa 0.0820 0.0380 0.00380 0.024 NA 0.071 NA 0.061 8.8e-03 NA 1.8e-05 NA 6.4e-05
5 GTEx Esophagus Muscularis 0.0700 0.0350 0.00710 0.053 NA 0.043 NA 0.051 3.8e-04 NA 1.3e-03 NA 4.8e-04
6 GTEx Lung 0.0603 0.0314 0.00270 0.082 NA 0.049 NA 0.061 7.9e-07 NA 1.1e-04 NA 2.0e-05
7 GTEx Whole Blood 0.0660 0.0260 0.00022 0.024 NA 0.034 NA 0.028 2.7e-03 NA 3.8e-04 NA 1.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.3 0.4 0.8 0.1 -0.3 -0.7 -0.9 -0.9 -0.7 -0.6
Bipolar Disorder or Schizophrenia 0.3 0.8 1.8 0.1 -0.2 -1.2 -0.5 -0.6 -1.3 -1.3
Depressed Affect (Nagel 2018) 0.3 0.6 1.5 0.2 -1.2 0.7 -0.6 0.0 0.7 1.1
Depression (Nagel 2018) 0.9 1.3 2.9 1.0 -0.3 -1.7 -0.4 -1.5 -1.5 -0.7
Intelligence (Savage-Jansen 2018) 0.7 2.1 4.3 -2.1 0.4 1.2 1.6 1.9 1.5 0.6
Neuroticism (Nagel 2018) 0.2 0.5 1.2 0.3 -0.4 0.7 0.1 0.7 1.0 1.1
Schizophrenia (2018) 0.3 0.5 1.4 0.3 -0.0 -1.0 0.1 -0.1 -1.1 -1.2
Schizophrenia vs Biploar Disorder 0.4 0.5 1.8 0.4 -0.7 0.0 -1.3 -0.2 0.0 1.2
Worry (Nagel 2018) 0.1 0.3 0.7 0.8 0.7 0.2 0.2 0.4 0.3 0.8
Alzheimer’s Disease (in mother) 0.6 0.7 2.1 0.1 -0.1 -1.0 -0.7 -0.7 -0.9 -1.5
Alzheimer’s Disease (in father) 0.4 0.4 1.5 0.2 0.0 0.9 -1.2 -0.2 0.9 -0.0
Alzheimer’s Disease (including proxy) 0.5 0.8 1.8 0.8 0.7 -0.7 -0.9 -0.9 -0.6 -1.3
Crohns Disease (2017) 0.7 1.6 3.8 -0.9 -0.4 1.6 -1.0 0.6 1.5 1.9
Irritable Bowel Disease (IBD) 0.9 2.1 3.8 -1.5 -0.8 1.9 -0.6 0.8 1.9 2.0
Ulcerative Colitis (UC) 0.6 1.0 1.8 -1.3 -1.3 1.1 0.1 0.7 1.1 0.9
Major Depression (MDD) 0.2 0.2 0.7 -0.4 0.7 -0.3 0.8 0.6 -0.2 0.2
Reaction Time 0.4 0.8 1.8 -1.3 -1.3 0.7 -0.9 -0.4 0.7 0.4
Verbal and Numeric Reasoning (VNR) 1.1 2.7 5.6 -2.2 0.3 1.2 1.7 2.4 1.3 1.5
Breast Cancer 0.4 1.0 2.5 0.6 0.5 0.8 -1.6 -1.1 0.8 1.0
Ovarian Cancer 1.1 1.5 3.4 -0.2 -1.8 1.2 -0.2 1.2 1.2 1.6
Prostate Cancer 2.7 3.7 6.7 -1.7 -2.3 2.2 -0.8 1.1 2.2 2.6
Age at First Birth 0.2 0.3 0.6 0.6 -0.8 0.6 -0.5 0.4 0.3 0.6
Bipolar Disorder (2011) 0.2 0.2 0.6 -0.2 -0.4 -0.1 0.5 0.8 -0.3 0.2
Body Mass Index (BMI) (2010) 0.3 0.4 0.7 0.7 -0.3 -0.8 -0.0 -0.5 -0.9 -0.5
Coronary Artery Disease (CAD) 0.2 0.2 0.5 -0.7 -0.7 -0.3 0.2 -0.0 -0.5 -0.6
Crohns Disease (2012) 0.4 0.6 2.3 -1.0 -0.1 0.6 -1.5 -0.4 0.5 0.2
Mean Putamen Volume 0.3 0.4 1.0 -1.0 -0.6 0.0 -0.9 -0.6 -0.0 -0.3
Fasting Glucose 0.5 0.6 1.6 0.6 -1.3 0.3 -0.7 0.6 0.9 -0.7
HbA1C 0.2 0.2 0.5 -0.2 -0.2 -0.4 -0.6 -0.7 -0.7 0.2
HDL Cholesterol 1.6 2.6 7.9 0.4 2.4 -0.6 2.8 1.7 -0.8 -0.8
LDL Cholesterol 0.2 0.3 0.8 0.2 -0.9 -0.5 -0.6 -0.6 -0.4 -0.4
Lupus 0.4 0.6 1.2 1.1 1.1 -0.7 -0.7 -0.6 -0.7 0.3
Neuroticism (2016) 1.3 1.8 4.4 -1.3 0.4 0.9 2.1 1.9 1.0 1.2
Primary Biliary Cirrhosis 0.1 0.1 0.3 -0.3 -0.5 0.3 -0.3 0.3 0.4 0.0
Rheumatoid Arthritis 0.5 0.6 1.1 1.1 0.5 -0.8 -0.3 -0.9 -0.9 -0.8
Schizophrenia (2014) 0.2 0.5 1.1 -0.1 -0.7 -0.9 -0.7 -0.2 -1.1 -0.8
Triglycerides 0.9 1.5 5.3 -0.8 -0.2 0.9 -2.3 -1.6 0.9 0.4
Type 2 Diabetes (T2D) (2012) 1.8 2.1 4.7 -2.2 -0.3 1.6 1.1 1.8 1.5 0.9
Ulcerative Colitis 0.4 0.5 2.1 -0.5 -1.4 0.3 -0.8 -0.6 0.4 0.2
Blood Eosinophil Count 0.1 0.5 1.2 0.3 -1.1 0.8 -0.6 0.2 0.9 0.2
Blood Platelet Count 0.0 0.3 0.8 0.3 0.5 0.0 -0.5 -0.9 0.1 -0.9
Blood Red Count 0.2 2.3 7.3 1.4 2.7 -0.8 0.1 -1.1 -0.8 -2.1
Blood White Count 0.2 1.1 3.2 -1.8 -1.4 0.3 1.2 1.0 0.4 0.2
Heel T-Score 1.1 8.7 23.6 2.7 1.2 -3.3 0.1 -2.5 -3.4 -4.9
BMI 0.3 1.8 4.7 2.0 -0.2 -0.8 -2.2 -1.5 -1.1 -0.2
Height 0.5 8.8 27.1 -1.7 -0.1 0.6 -5.2 -4.8 0.8 -2.7
Waist Hip Ratio (WHR) 0.4 1.7 4.5 -0.1 0.7 -1.7 0.7 -0.8 -1.7 -2.1
Systolic Blood Pressure 4.8 24.0 60.7 3.3 3.3 -6.1 1.4 -2.8 -6.2 -7.8
Smoking Status 1.9 4.5 8.4 1.7 2.9 -2.4 0.6 -1.7 -2.2 -2.5
Allergy or Eczema 0.3 0.8 1.6 1.2 1.1 -0.3 1.3 -0.0 -0.4 -1.0
Cardiovascular Disease 2.0 6.8 19.1 2.2 1.5 -3.1 1.3 -0.9 -3.0 -4.4
Hypothyroidism (self reported) 0.6 1.5 3.3 1.6 -0.8 0.9 -1.8 -1.0 0.9 1.0
Respiratory disease 0.2 0.3 1.3 0.3 -0.9 0.1 -1.1 -0.5 0.1 -0.2
Type 2 Diabetes (T2D) (2018) 1.7 3.2 8.0 1.2 0.9 -1.9 2.2 0.7 -1.9 -2.8
Lung FEV1/FVC ratio 0.6 3.0 7.2 1.9 0.6 -1.4 -0.9 -2.7 -1.5 -2.3
Lung FVC 1.3 6.9 21.3 2.2 4.6 -1.8 3.3 1.1 -1.6 -1.9
Neuroticism 0.2 0.4 1.0 0.1 -0.5 0.3 0.4 1.0 0.7 1.0
Chronotype (morning person) 0.1 0.2 0.7 -0.1 0.5 0.3 0.1 0.9 0.6 -0.1
Hair Pigment 0.0 0.7 1.6 -0.7 -1.2 0.4 -0.0 1.1 0.5 1.2
Tanning 0.1 0.9 2.8 0.2 1.7 -0.6 1.5 0.6 -0.8 -0.0
Hand grip strength (left) 0.8 2.2 3.4 1.3 1.9 -0.9 -1.8 -1.8 -0.9 -1.4
Number of treatments/medications taken 0.5 0.9 3.5 0.9 0.5 -0.7 0.8 -0.5 -0.7 -1.9
Average weekly spirits intake 0.3 0.4 0.6 0.3 -0.1 -0.4 0.8 0.7 -0.7 -0.8
Sensitivity / hurt feelings 0.6 1.0 3.0 -0.6 -1.0 0.6 0.9 1.7 0.6 1.0
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.2 0.1 -0.2 -1.5 -0.4 -1.2 -1.3 -0.3
Hearing difficulty/problems: Yes 0.2 0.2 0.6 0.4 -0.5 -0.8 -0.3 -0.1 -0.8 -0.2
Relative age of first facial hair 0.1 0.2 0.5 0.1 0.7 0.3 -0.5 -0.2 0.5 0.4
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 4.4 -0.4 -2.1 0.8 -1.4 -0.6 0.9 0.9
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.6 -0.8 1.5 0.1 1.9 1.5 0.2 0.3
Ever had hysterectomy (womb removed) 0.4 0.4 1.9 -0.3 1.4 0.3 0.1 0.6 0.3 0.6
Systolic blood pressure, automated reading 1.9 5.6 13.4 0.8 2.4 -3.0 0.7 -1.0 -3.0 -3.7
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 5.8 0.7 -1.8 -0.7 -2.4 -1.7 -0.6 -0.9
Angina 0.7 0.9 1.8 1.3 0.2 -0.5 1.3 0.8 -0.5 -1.2
Medication for hormone replacement therapy 0.7 0.8 2.4 -0.4 0.3 0.9 1.0 1.5 0.8 0.5
Vitamin and mineral supplements 0.1 0.2 0.5 0.3 0.7 0.1 0.6 0.2 0.1 -0.6
Supplements: Zinc 0.5 0.5 1.1 -1.0 -1.1 -0.1 -1.0 -0.6 -0.0 -0.4
Medication: Co-codamol 0.5 0.6 1.2 -1.1 -0.8 0.5 0.7 0.9 0.3 0.9
Medication: Metformin 0.7 1.0 3.9 0.1 0.1 -1.3 0.1 -0.2 -1.2 -2.0
Diabetes (father) 0.9 1.1 3.6 -1.1 -0.2 0.4 1.9 1.5 0.3 -0.4
Diabetes (mother) 0.1 0.2 0.4 0.4 -0.4 0.1 -0.6 -0.3 0.3 -0.4
Severe depression (siblings) 1.8 2.0 5.4 -0.5 -0.5 1.5 1.0 1.6 1.4 2.3
Pack years adult smoking proportion 0.2 0.2 1.2 0.2 1.1 0.0 0.4 -0.3 0.0 -0.5
Impedance of leg (right) 0.5 2.3 8.5 -2.0 -2.9 1.2 -0.5 0.2 1.4 0.1
Leg fat-free mass (left) 1.0 5.2 11.8 1.8 1.7 -1.8 -2.8 -3.4 -2.0 -2.0
Trunk fat percentage 0.2 0.6 2.3 -0.3 -1.5 0.1 -1.0 -0.7 -0.0 -0.5
Hand grip strength (right) 0.9 2.4 3.8 1.3 1.4 -1.2 -1.7 -1.9 -1.2 -1.9
Townsend deprivation index at recruitment 0.2 0.3 0.7 0.2 0.8 -0.3 0.8 0.6 -0.2 0.3
Current tobacco smoking 0.3 0.4 1.2 0.5 1.1 -0.6 1.1 0.1 -0.3 -0.3
Average weekly fortified wine intake 0.2 0.2 0.8 -0.5 -0.5 0.0 -0.3 0.4 -0.0 0.9
Maternal smoking around birth 0.1 0.2 0.7 0.4 0.9 -0.1 0.5 0.5 -0.2 -0.3
Fed-up feelings 0.2 0.4 1.0 -0.8 -1.0 0.2 -0.8 -0.4 0.4 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 4.0 1.2 -0.3 -1.9 -0.8 -2.0 -1.6 -1.6
Relative age voice broke 1.6 2.4 3.6 -1.3 1.0 1.5 1.5 1.9 1.7 1.8
Taking other prescription medications 0.2 0.4 0.8 0.9 -0.8 -0.0 -0.6 -0.5 0.1 -0.7
Age when periods started (menarche) 1.5 3.6 6.1 -1.4 1.9 2.5 1.0 1.7 2.4 2.1
Bilateral oophorectomy (both ovaries removed) 2.3 2.6 4.1 -1.8 0.1 2.0 0.2 1.9 1.9 1.9
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 6.3 0.7 -2.2 -0.5 -2.5 -1.5 -0.8 -0.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.7 1.1 0.4 -0.7 -0.2 -0.6 -0.9 -1.3
Qualifications: CSEs or equivalent 0.9 1.1 2.9 1.0 -0.5 -0.7 -1.7 -1.6 -0.7 -0.5
Serious illness, injury or assault to yourself 0.3 0.3 0.6 0.4 0.3 0.8 0.7 0.5 0.7 0.3
High blood pressure 2.8 7.8 19.0 2.7 2.1 -3.3 0.9 -1.2 -3.3 -4.4
Hayfever, allergic rhinitis or eczema 0.1 0.2 1.1 1.1 0.2 -0.1 0.5 -0.0 -0.2 -0.5
Multivitamins +/- minerals 0.4 0.5 1.4 0.2 -0.4 -0.6 -1.2 -1.0 -0.6 0.0
Stomach or abdominal pain in last month 0.3 0.4 0.7 -0.8 0.2 0.7 -0.7 -0.2 0.8 -0.1
Supplements: Glucosamine 0.5 0.6 1.9 0.4 -1.0 -0.7 -1.4 -0.5 -0.7 0.3
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.5 0.0 1.2 -0.3 -0.4 -0.5 -0.3 -1.2
Medication: Atenolol 1.8 2.2 4.6 -0.3 0.1 -1.8 2.0 0.6 -1.8 -2.1
Medication: Levothyroxine sodium 0.7 1.2 3.6 0.9 -0.8 0.6 -1.9 -0.7 0.6 1.4
Sitting height 0.7 4.7 12.0 0.1 0.8 -1.2 -2.4 -3.4 -1.1 -3.5
Chronic bronchitis/emphysema (father) 0.2 0.2 0.6 0.1 -0.2 0.5 0.2 0.8 0.7 0.4
High blood pressure (mother) 1.4 1.9 6.0 2.4 0.1 -1.6 -0.0 -1.2 -1.4 -1.1
Body mass index (BMI) 0.2 0.9 2.7 1.0 -0.0 -0.6 -1.6 -1.2 -0.9 -0.3
Impedance of leg (left) 0.5 2.4 10.6 -1.6 -3.3 0.9 -1.1 -0.3 1.2 -0.2
Leg predicted mass (left) 1.0 5.3 12.0 1.8 1.6 -1.8 -2.8 -3.5 -2.0 -2.0
Trunk fat mass 0.4 1.6 4.7 0.0 -0.8 -0.3 -2.2 -2.0 -0.5 -1.1
Waist circumference 0.2 0.7 1.8 -0.4 -0.6 -0.5 -1.3 -1.2 -0.7 -0.8
Number of incorrect matches in round 0.4 0.7 3.7 -0.5 -1.9 0.3 -0.7 0.1 0.4 0.2
Past tobacco smoking 3.2 5.8 9.6 -2.3 -2.6 2.9 -0.5 1.7 2.8 3.1
Alcohol usually taken with meals 0.0 0.1 0.1 -0.3 -0.3 -0.2 -0.0 -0.0 -0.3 -0.3
Nervous feelings 0.2 0.3 1.1 0.1 0.9 0.3 0.2 -0.2 0.4 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.1 0.7 -1.0 -1.4 0.0 -0.4 -1.4 -0.8
Hearing difficulty/problems with background noise 0.5 0.8 1.7 0.7 0.0 -1.3 0.4 0.1 -1.2 -1.3
Hair/balding pattern: Pattern 2 0.8 1.0 3.0 0.7 -1.6 0.2 -1.7 -0.7 0.0 0.5
Had menopause 0.6 0.8 1.8 -1.3 0.2 0.4 1.2 1.4 0.4 0.4
Had other major operations 1.7 2.0 3.8 -1.8 -0.5 1.6 0.3 1.9 1.6 1.3
Forced vital capacity (FVC) 1.7 6.7 12.1 2.5 2.5 -2.3 -1.2 -3.5 -2.0 -3.4
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.7 0.6 -1.6 -0.5 -1.9 -1.2 -0.7 -1.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.6 -0.5 0.2 -0.1 0.7 0.7 -0.2 0.6
Qualifications: None of the above 0.1 0.1 0.3 0.4 0.3 0.2 -0.4 -0.5 0.2 -0.3
Financial difficulties in last 2 years 0.6 0.8 1.4 0.7 0.2 -1.1 -0.3 -0.9 -1.2 -1.2
Mouth/teeth dental problems 0.6 0.9 2.2 -1.3 0.7 0.3 1.5 1.3 0.2 -0.1
Heart attack 1.5 1.9 4.2 0.9 1.3 -1.0 2.0 0.8 -1.0 -1.9
Allergy 0.3 0.7 2.1 -1.0 -0.3 0.9 -0.5 0.1 0.9 1.4
Pain all over the body in last month 0.2 0.2 0.4 -0.1 -0.3 0.5 0.4 0.3 0.4 0.6
Diabetes (self-reported) 0.9 1.4 2.6 0.6 0.3 -1.4 1.6 0.7 -1.4 -1.5
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.6 0.8 0.1 0.1 -0.2 0.3 0.1 0.0
Medication: Ramipril 0.5 0.7 1.9 0.8 1.4 -0.4 -0.0 -0.6 -0.3 -1.2
Medication: Simvastatin 2.3 3.4 9.1 -3.0 0.3 0.8 2.6 2.5 0.8 0.1
Fluid intelligence score 0.4 0.7 2.3 -1.5 0.1 0.2 1.0 1.2 0.3 0.4
Illnesses of siblings 1.0 1.4 3.3 -1.2 -1.4 1.0 0.5 1.0 1.0 1.8
Neuroticism score 0.2 0.5 1.2 -0.4 -0.5 0.4 0.9 1.1 0.6 0.8
Weight 0.8 4.1 11.8 0.8 0.2 -1.0 -3.4 -3.3 -1.2 -1.6
Impedance of arm (right) 0.9 4.3 14.4 -2.1 -0.9 1.1 3.8 2.7 1.5 0.4
Arm fat percentage (right) 0.0 0.1 0.4 0.2 -0.7 -0.0 -0.4 -0.2 -0.2 -0.2
Trunk fat-free mass 1.4 8.2 21.5 1.6 1.6 -1.4 -4.6 -4.6 -1.6 -2.3
Hip circumference 0.3 1.4 5.2 -0.0 -0.9 -0.3 -2.3 -1.8 -0.5 -0.4
Time employed in main current job 1.1 1.2 3.1 -1.7 0.6 0.4 1.3 1.8 0.5 0.4
Alcohol intake versus 10 years previously 0.4 0.7 1.7 -0.9 0.7 0.3 1.3 1.2 0.2 -0.1
Father’s age at death 2.0 2.7 6.7 -1.6 0.0 1.8 1.0 1.7 1.5 2.6
Worrier / anxious feelings 0.3 0.6 1.8 0.4 0.7 -0.6 1.4 0.8 -0.5 -0.5
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.5 3.5 1.7 -0.3 -1.8 -1.2 -1.8 -1.9 -1.8
Falls in the last year 0.4 0.6 1.0 0.8 -0.3 -1.0 -0.4 -0.8 -0.8 -1.0
Hair/balding pattern: Pattern 3 0.5 0.8 2.6 -0.2 1.2 0.5 1.6 0.9 0.3 -0.4
Number of live births 0.4 0.6 1.5 0.8 -1.2 -0.6 -1.0 -0.3 -0.5 -0.2
Forced expiratory volume in 1-second (FEV1) 2.1 6.9 13.5 2.9 2.1 -2.2 -1.7 -3.7 -2.1 -3.2
Pulse rate 0.7 1.2 3.1 -0.8 1.8 1.2 0.9 0.5 1.4 0.3
Happiness 0.1 0.2 0.8 -0.3 -0.3 0.2 -0.9 -0.4 0.3 0.1
Noisy workplace 0.5 0.6 2.4 -0.1 -1.6 0.5 -0.9 0.1 0.5 0.6
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.9 -1.3 0.2 0.6 0.7 1.4 0.6 1.3
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.6 0.8 0.1 -0.4 -0.7 -0.5 -0.4 0.1
Mouth/teeth dental problems: Dentures 1.3 2.2 4.7 1.5 -0.1 -1.6 -1.9 -2.2 -1.4 -0.6
Asthma 0.4 0.7 2.8 0.1 -1.7 0.0 -1.2 -0.5 0.1 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.6 1.0 -0.2 0.3 -0.8 -1.3 0.1 0.2
Medication: Cholesterol lowering 0.8 1.2 4.5 -0.4 0.1 -0.5 2.1 1.2 -0.5 -1.3
Depression (self-reported) 0.4 0.5 1.3 1.2 -0.5 -0.9 -0.1 -0.5 -0.8 -0.4
Medication: Lansoprazole 0.0 0.1 0.3 -0.2 -0.2 -0.0 0.1 -0.0 0.1 0.5
Prospective memory result 1.0 1.2 2.2 1.5 0.6 -1.4 0.0 -0.9 -1.4 -1.0
Lung cancer (father) 0.1 0.2 0.5 0.6 -0.7 -0.1 -0.3 -0.2 -0.1 -0.5
Illnesses of mother 1.3 1.7 6.1 -0.6 0.2 1.4 -1.1 -0.1 1.4 2.5
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 7.9 14.3 3.1 2.0 -2.7 -1.5 -3.8 -2.5 -3.3
Pulse wave Arterial Stiffness index 1.0 1.2 5.4 -2.3 -0.6 0.9 -0.7 -0.8 0.8 0.1
Impedance of arm (left) 1.2 5.5 13.9 -2.5 -1.4 1.5 3.7 3.0 1.9 0.9
Arm fat mass (right) 0.2 0.9 3.1 0.5 -0.3 -0.4 -1.8 -1.5 -0.6 -0.6
Trunk predicted mass 1.4 7.9 20.9 1.5 1.6 -1.4 -4.6 -4.5 -1.5 -2.2
Standing height 0.7 7.1 22.2 -0.7 0.4 -0.7 -4.3 -4.7 -0.5 -2.9
Length of working week for main job 0.5 0.6 1.4 -0.7 0.1 -0.5 1.2 0.9 -0.4 -0.8
Exposure to tobacco smoke at home 2.5 2.8 5.0 1.9 1.0 -1.9 -0.6 -1.4 -2.0 -2.2
Breastfed as a baby 1.1 1.4 3.3 0.2 -0.6 1.8 -0.7 0.5 1.7 1.5
Tense / ‘highly strung’ 0.2 0.3 0.7 -0.2 0.7 -0.7 0.7 0.0 -0.6 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 3.0 1.7 0.0 -1.7 -0.8 -1.4 -1.5 -1.4
Hair/balding pattern: Pattern 4 0.8 1.9 7.8 1.4 2.8 -1.0 0.8 -0.5 -0.9 -0.9
Birth weight of first child 2.4 4.4 9.7 -2.7 -0.2 1.9 2.0 3.1 2.0 1.6
Peak expiratory flow (PEF) 1.8 4.2 7.8 2.8 1.9 -1.4 -1.1 -2.3 -1.4 -2.7
Pulse wave reflection index 2.6 3.2 9.4 -0.0 -0.5 -1.5 -1.9 -3.1 -1.6 -2.0
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.2 -1.3 0.2 1.5 0.4 1.3 1.3 1.3
Loud music exposure frequency 0.7 0.8 3.8 0.6 -1.9 0.1 -0.8 -0.3 -0.1 -0.7
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.1 -0.1 -0.7 -0.9 0.5 1.1 -1.0 -0.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 3.0 1.2 1.7 0.1 0.4 -0.1 0.2 -0.0
Blood clot in the leg (DVT) 2.0 2.6 4.0 1.4 0.9 -2.0 -1.6 -1.9 -1.9 -1.4
Medication: Paracetamol 0.5 0.8 2.3 1.5 0.1 1.1 -0.5 -0.8 1.1 0.1
Headache pain in last month 0.2 0.3 1.0 0.5 0.1 0.3 -1.0 -1.0 0.3 -0.1
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 4.0 -0.4 -0.5 1.1 -2.0 -0.5 1.1 1.6
Glaucoma (self-reported) 0.2 0.2 1.1 0.2 0.1 -0.2 1.1 0.7 -0.2 0.1
Gout (self-reported) 0.5 0.8 1.7 1.0 0.7 -0.9 0.5 0.4 -0.9 -1.3
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 3.2 1.8 -0.3 0.4 -1.8 -1.1 0.4 1.1
Medication: Amlodipine 0.9 1.3 3.4 1.0 1.8 -0.3 1.5 -0.5 -0.5 -1.3
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.0 0.2 -0.5 1.2 -1.3 -0.0 1.4 1.7
Birth weight 1.3 2.8 8.9 -1.1 1.0 0.4 2.8 3.0 0.3 0.7
Chronic bronchitis/emphysema (mother) 1.2 1.4 4.2 -1.2 -0.2 0.1 2.0 2.0 0.2 -0.4
High blood pressure (siblings) 2.4 3.4 6.9 2.6 2.2 -1.8 -0.0 -1.3 -1.9 -1.9
Forced vital capacity (FVC), Best measure 2.1 7.6 12.4 2.8 2.3 -2.8 -1.2 -3.5 -2.5 -3.5
Body fat percentage 0.2 0.7 1.9 -0.1 -1.3 -0.1 -1.4 -1.0 -0.2 -0.6
Leg fat percentage (right) 0.3 1.1 3.3 0.2 -0.7 -0.3 -1.8 -1.6 -0.5 -0.9
Arm fat-free mass (right) 1.7 8.5 24.1 1.5 0.9 -1.6 -4.9 -4.6 -1.8 -2.3
Exposure to tobacco smoke outside home 0.8 1.1 2.3 1.5 -0.5 -1.5 -0.2 -0.7 -1.5 -0.6
Comparative body size at age 10 0.5 1.5 3.3 1.8 1.8 -1.3 0.6 -0.5 -1.3 0.0
Number of full brothers 0.8 1.0 2.6 0.7 1.6 -0.3 -0.4 -1.6 -0.5 -0.7
Worry too long after embarrassment 0.9 1.6 2.9 -1.3 -0.9 1.1 0.6 1.7 1.3 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.3 1.0 -0.2 -1.1 0.3 -0.6 -1.1 -0.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 0.1 -0.1 0.6 0.1 0.6 0.7 0.0
Number of children fathered 0.5 0.6 0.9 -0.5 1.0 0.7 0.7 0.8 0.7 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.5 -0.8 0.2 0.8 1.1 1.2 0.9 0.6
Age at first live birth 0.5 0.9 3.2 -0.2 1.1 -0.3 1.8 1.2 -0.2 0.2
Pulse wave peak to peak time 0.8 0.9 4.3 2.1 0.5 -0.8 0.5 0.7 -0.7 -0.2
Health satisfaction 1.5 2.0 4.3 1.2 -1.3 -1.0 -2.1 -1.9 -1.1 -0.9
Shortness of breath walking on level ground 1.0 1.2 4.2 -0.4 -0.3 -0.3 1.8 2.1 -0.3 -0.3
Qualifications: College or University degree 0.4 1.4 3.5 0.3 0.6 0.1 1.9 1.6 0.2 1.8
Eye problems/disorders: None of the above 0.8 1.0 2.6 -1.2 1.0 -0.0 1.6 1.3 0.1 0.5
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.5 0.7 -0.2 -0.5 -0.5 -0.4 -0.4 -0.5
Emphysema/chronic bronchitis 0.6 0.7 2.3 0.1 0.5 -0.3 1.5 1.5 -0.4 -0.2
Medication for pain relief, constipation, heartburn 0.5 0.9 3.2 -1.1 -0.6 -0.0 0.7 1.8 0.1 1.0
Neck or shoulder pain in last month 0.4 0.5 1.3 0.5 0.5 -0.9 0.0 -0.7 -0.8 -1.2
Medication: Blood pressure 1.6 2.9 6.3 1.4 1.9 -1.3 2.5 0.6 -1.4 -2.1
Angina (self-reported) 0.6 0.7 1.7 1.1 -0.1 -0.3 1.3 1.0 -0.3 -1.1
Migraine (self-reported) 0.6 0.7 2.9 0.7 0.0 0.2 -1.7 -1.1 0.3 0.6
Medication: Ibuprofen 0.2 0.3 1.2 0.9 0.0 0.0 -0.2 -1.1 -0.1 0.3
Medication: Allopurinol 0.4 0.5 2.1 -0.3 0.1 0.2 1.1 1.4 0.2 -0.4
Medication: Omeprazole 0.9 1.1 2.1 1.4 0.7 -0.9 -0.3 -1.3 -0.9 -1.3
Medication: Seretide 50 evohaler 0.7 0.8 1.7 0.9 0.4 -0.7 -0.8 -1.3 -0.7 -1.0
Mean time to correctly identify matches 0.6 1.1 3.5 -1.9 -0.7 1.2 -0.3 0.2 1.2 0.5
Heart disease (mother) 0.5 0.6 2.5 0.3 0.0 -0.9 0.7 -0.1 -0.8 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.4 0.1 1.3 0.5 1.8 1.8 0.5 0.2
Whole body fat mass 0.5 2.0 5.8 0.4 -0.6 -0.6 -2.4 -2.2 -0.8 -1.2
Leg fat mass (right) 0.6 2.3 6.4 0.6 -0.1 -0.8 -2.5 -2.4 -1.0 -1.2
Arm predicted mass (right) 1.6 8.2 24.2 1.6 0.8 -1.5 -4.9 -4.6 -1.7 -2.1
Pulse rate, automated reading 0.6 2.0 6.9 -0.6 2.6 0.7 2.0 0.8 0.8 0.8
Alcohol intake frequency. 0.1 0.2 0.8 -0.2 0.6 0.2 0.9 0.7 0.2 0.0
Comparative height size at age 10 0.8 4.6 12.6 -0.0 -1.1 -1.2 -3.2 -3.5 -1.2 -2.3
Number of full sisters 1.2 1.5 3.7 -1.9 -0.1 1.6 -1.1 0.3 1.7 0.3
Suffer from ‘nerves’ 0.2 0.3 0.8 -0.9 0.7 0.1 -0.5 -0.5 0.2 0.7
Overall health rating 0.4 1.0 4.1 0.5 -2.0 0.1 -1.3 -0.8 0.1 0.1
Chest pain or discomfort 0.5 0.7 1.5 0.2 1.2 -0.5 1.2 0.9 -0.4 -0.8
Had major operations 5.3 6.2 10.6 1.6 2.8 -3.2 2.1 -0.6 -3.2 -2.7
Age at last live birth 0.2 0.3 1.0 0.7 -1.0 -0.4 0.1 -0.1 -0.3 0.5
Family relationship satisfaction 0.4 0.5 1.6 -1.3 -0.4 0.4 0.1 0.8 0.4 0.9
Leg pain on walking 1.3 1.7 3.0 -1.2 -1.7 1.3 -1.3 0.5 1.1 1.5
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.9 0.5 0.6 -1.1 -0.2 -1.0 -1.4 -1.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.8 0.4 -0.7 -0.2 -0.9 0.0 -0.1 0.0
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 -0.1 0.5 -0.3 -0.4 -0.5 -0.3 0.1
Medication: Aspirin 0.8 1.0 2.8 -0.3 1.2 -0.8 1.2 0.1 -1.0 -1.7
Supplements: Vitamin C 1.1 1.4 6.9 0.3 -2.6 0.1 -1.4 -0.4 0.1 0.5
Knee pain experienced in last month 4.9 7.6 11.6 2.8 -0.6 -2.9 -2.7 -3.4 -2.8 -3.2
Hypertension (Self-reported) 2.6 7.3 18.4 2.4 1.9 -3.3 1.1 -1.1 -3.2 -4.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.4 5.6 0.7 -1.9 -0.6 -2.4 -2.0 -0.7 -1.6
Illnesses of father: Heart disease 0.7 1.0 2.0 0.6 1.0 -1.1 0.5 -0.7 -1.3 -1.4
Illnesses of siblings: Diabetes 0.8 0.9 4.2 0.3 0.9 -0.8 0.3 -0.0 -0.9 -2.0
Smoking status: Previous 2.7 4.0 7.8 1.5 2.0 -2.4 -0.0 -1.7 -2.4 -2.8
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.7 -0.0 -1.0 -1.1 -1.5 -2.2 -0.9 -1.4
Whole body fat-free mass 1.4 8.1 19.9 1.8 1.6 -1.7 -4.3 -4.5 -1.9 -2.4
Leg fat-free mass (right) 1.0 5.6 12.6 1.9 1.6 -1.9 -2.9 -3.5 -2.0 -2.0
Arm fat percentage (left) 0.0 0.2 0.8 -0.2 -0.9 0.4 -0.4 0.1 0.2 0.3
Average weekly red wine intake 1.1 1.6 3.3 -0.5 -1.1 1.5 0.3 1.8 1.7 1.0
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.6 -1.3 -0.4 1.0 -0.2 0.1 0.8 0.9
Mood swings 0.0 0.1 0.1 0.2 -0.3 -0.1 0.3 -0.2 0.1 0.2
Loneliness, isolation 0.1 0.1 0.2 -0.0 -0.5 0.3 0.0 0.2 0.4 -0.2
Long-standing illness, disability or infirmity 0.2 0.4 1.3 0.3 -1.1 -0.5 0.3 -0.3 -0.4 -0.9
Ever had bowel cancer screening 2.9 3.3 7.7 -2.8 0.9 1.3 2.3 2.3 1.4 0.8
Diabetes diagnosed by doctor 1.1 1.9 4.0 0.6 0.7 -1.5 2.0 0.8 -1.5 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 4.2 4.4 6.4 0.9 -1.6 -2.3 -2.5 -2.5 -2.4 -1.9
Friendships satisfaction 0.9 1.1 1.9 -1.4 -1.3 0.7 -1.1 0.4 0.8 1.2
Qualifications: nursing, teaching 0.4 0.7 1.7 1.0 0.3 -1.3 -0.4 -0.3 -1.3 -0.3
Commuting to job workplace: Walk 0.7 0.8 2.0 0.3 -1.4 0.6 -1.4 -0.2 0.5 1.0
Eye problems/disorders: Cataract 2.3 2.7 5.6 1.6 0.7 -1.9 -0.4 -1.6 -1.9 -2.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.6 -0.8 -0.8 0.8 -0.5 0.3 0.7 0.8
Medication for cholesterol 0.5 0.8 2.6 -0.3 -1.6 0.6 -0.8 -0.3 0.5 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.0 1.2 -0.8 -1.1 -1.1 -1.4 -1.1 -0.9
Back pain experienced in last month 0.9 1.3 4.1 -0.3 -2.0 0.9 -1.3 0.4 1.0 1.2
Mineral and other dietary supplements 0.2 0.3 1.1 0.3 0.7 0.2 1.1 0.5 0.3 0.1
Breast cancer (self-reported) 0.4 0.5 1.0 0.9 -0.6 -1.0 -0.1 0.0 -1.0 -0.4
Asthma (self-reported) 0.3 0.7 2.6 0.2 -1.6 -0.0 -1.3 -0.6 0.0 -0.5
Osteoporosis (self-reported) 0.3 0.4 1.5 -1.2 -0.4 0.2 0.1 0.2 0.6 0.8
Osteoarthritis (self-reported) 0.4 0.5 1.2 1.1 0.1 0.6 -0.6 0.8 0.5 0.7
Medication: Aspirin 0.5 0.6 2.0 -0.3 0.7 -0.5 1.1 0.4 -0.6 -1.4
Medication: Gliclazide 3.2 3.6 9.9 1.0 0.8 -2.3 -0.5 -1.9 -2.1 -3.1
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 -0.4 -0.3 -0.3 -0.7 -0.6 -0.3 -0.4
Smoking status: Current 0.2 0.3 0.9 0.1 0.9 -0.3 1.0 0.4 -0.0 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 3.0 6.1 1.5 0.6 -2.2 -0.1 -1.5 -2.2 -2.5
Whole body water mass 1.4 8.0 20.1 1.8 1.5 -1.8 -4.2 -4.5 -1.9 -2.4
Leg predicted mass (right) 1.1 5.6 12.7 1.9 1.6 -1.9 -2.9 -3.6 -2.1 -2.0
Arm fat mass (left) 0.2 0.8 3.1 0.3 -0.3 -0.2 -1.8 -1.4 -0.4 -0.4
Number of self-reported non-cancer illnesses 0.3 0.5 3.2 0.4 -0.3 -0.4 0.1 -0.0 -0.4 -1.8
Average weekly champagne plus white wine intake 0.3 0.4 1.2 -0.2 0.0 -0.4 -0.8 -1.1 -0.6 -0.5
Miserableness 0.4 0.7 1.4 1.1 -0.4 -1.2 0.6 -0.4 -1.1 0.0
Guilty feelings 0.9 1.4 3.7 0.1 -1.9 1.2 -1.1 -0.2 1.4 1.2
Wears glasses or contact lenses 1.1 1.2 3.6 -0.3 0.0 1.3 0.9 1.9 1.3 0.8
Ever taken oral contraceptive pill 0.3 0.4 1.0 -0.1 0.2 -0.6 -1.0 -0.9 -0.6 -0.2
Hearing aid user 0.4 0.5 1.6 -0.1 1.2 -0.2 1.2 0.5 -0.2 0.5
Mother’s age at death 1.0 1.2 2.3 -0.7 -1.3 1.4 -0.2 0.8 1.3 1.5
Financial situation satisfaction 0.4 0.4 1.0 -0.8 -0.8 0.4 -1.0 -0.8 0.4 -0.1
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.1 0.1 1.1 0.0 0.9 0.8 -0.0 0.4
Commuting to job workplace: Public transport 0.8 0.9 2.6 -1.3 1.1 0.1 1.6 0.9 -0.0 0.4
Eye problems/disorders: Glaucoma 0.4 0.5 1.5 -0.0 0.7 0.4 1.2 0.8 0.4 0.6
Medication: Blood pressure 4.5 8.6 17.0 2.5 1.9 -3.7 -0.2 -2.6 -3.6 -4.1
Pain type(s) experienced in last month: Hip pain 2.5 3.2 5.6 -0.9 -2.3 2.4 -0.9 1.0 2.3 1.8
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.5 -0.7 -1.2 0.2 -0.8 -0.3 0.0 0.4
High cholesterol (Self-reported) 1.3 2.3 5.9 -2.0 1.0 0.2 2.4 2.2 0.3 -0.3
Medication: Bendroflumethiazide 0.9 1.4 2.3 0.6 -1.5 -1.5 0.9 0.3 -1.5 -1.5
Medication: Paracetamol 0.8 1.3 3.3 1.4 0.1 1.7 -0.4 -0.5 1.8 0.5
Medication: Lisinopril 1.1 1.4 2.5 0.5 1.4 -1.5 1.6 0.1 -1.4 -1.1
Medication: Atorvastatin 1.8 2.2 5.2 0.6 2.3 -1.3 1.8 0.7 -1.2 -1.7
Illnesses of father: High blood pressure 0.7 0.9 1.7 1.0 -0.4 -1.3 -0.6 -0.8 -1.3 -0.8
Alcohol drinker status: Never 0.7 0.8 2.5 0.3 1.6 0.5 1.3 0.9 0.4 0.4
Ever smoked 2.8 4.9 7.2 2.6 2.1 -2.7 0.3 -1.7 -2.5 -2.5
Basal metabolic rate 1.4 7.6 19.3 1.7 1.2 -1.7 -4.2 -4.4 -1.9 -2.4
Leg fat percentage (left) 0.4 1.3 4.5 0.2 -0.9 -0.2 -2.1 -1.7 -0.4 -0.9
Arm fat-free mass (left) 1.8 8.9 23.6 1.6 0.9 -1.7 -4.9 -4.7 -1.9 -2.5
Number of operations (self-reported) 0.2 0.3 0.6 -0.6 -0.3 -0.6 0.3 0.4 -0.8 -0.6
Average weekly beer plus cider intake 0.3 0.4 0.9 -0.3 -1.0 -0.2 -1.0 -0.8 -0.1 -0.2
Irritability 0.5 0.9 3.1 -0.0 1.3 -0.5 1.8 0.3 -0.6 -1.0
Risk taking 0.7 1.1 2.6 1.0 -0.2 -1.3 -0.3 -0.5 -1.4 -1.6
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.4 0.9 1.6 0.3 -0.7 -1.1 0.2 -0.6
Fractured/broken bones in last 5 years 0.2 0.3 0.9 0.4 0.0 0.8 -0.2 -0.2 1.0 0.1
Age started oral contraceptive pill 0.3 0.4 1.0 -0.2 -0.9 0.1 -0.6 0.5 0.2 1.0
Diastolic blood pressure, automated reading 1.0 3.1 5.4 0.4 2.2 -1.9 -0.1 -1.6 -2.2 -2.3
Ever depressed for a whole week 0.9 1.1 3.6 0.5 0.4 -1.2 1.9 1.0 -1.2 -0.6
Unable to work because of sickness or disability 0.6 0.8 1.8 1.4 0.7 -0.5 -0.5 -1.1 -0.3 -1.2
Commuting to job workplace: Cycle 0.4 0.5 1.7 0.2 1.3 -0.7 0.4 -0.5 -0.6 0.4
Myopia 0.4 0.6 1.6 -0.5 0.3 0.4 1.3 1.2 0.5 0.3
Vascular/heart problems diagnosed by doctor 3.2 8.7 21.9 -2.8 -2.1 3.4 -1.0 1.4 3.4 4.7
Cholesterol lowering medication 1.5 2.2 4.6 -1.7 1.7 -0.1 2.1 2.0 0.1 -0.8
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.0 1.3 -0.1 -1.1 -0.6 -1.4 -0.9 -1.4
Pain experienced in last month 0.8 1.4 3.7 -0.6 1.0 0.6 1.9 1.5 0.5 1.2
Supplements: Calcium 0.3 0.4 1.1 -0.9 -0.5 0.3 -1.1 -0.1 0.4 0.0
Basal cell carcinoma (self-reported) 1.0 1.1 2.2 -0.1 -0.5 -1.4 -1.0 -1.4 -1.5 -0.9
Heart attack/myocardial infarction (self-reported) 1.3 1.7 3.9 0.9 1.4 -0.9 2.0 0.9 -0.9 -1.8
Deep venous thrombosis (DVT) (self-reported) 1.9 2.4 3.5 1.3 0.9 -1.9 -1.6 -1.9 -1.7 -1.4
Heart disease (siblings) 0.4 0.5 0.9 -0.7 1.0 0.3 -0.9 -0.8 0.4 -0.8
Alcohol drinker status: Previous 2.7 3.1 6.3 2.0 0.8 -2.2 0.1 -1.1 -2.1 -2.5
Pack years of smoking 0.2 0.3 1.0 -0.3 1.0 0.6 0.7 0.3 0.5 -0.1
Impedance of whole body 0.5 2.7 6.0 -1.9 -2.5 1.1 1.8 1.6 1.4 0.3
Leg fat mass (left) 0.6 2.4 7.1 0.6 -0.2 -0.8 -2.7 -2.4 -1.0 -1.3
Arm predicted mass (left) 2.0 10.0 25.6 1.9 1.0 -1.9 -5.1 -5.0 -2.1 -2.5