Hub : Genes

C1orf69

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0244 0.0113 0.00035 0.013 0.014 0.009 0.014 0.011 0.00004 0.00002 0.00038 1.4e-05 0.00013
2 TCGA Kidney Renal Papillary Cell Carcinoma 0.0480 0.0350 0.00390 0.017 0.030 0.028 NA 0.026 0.03600 0.00730 0.00910 NA 0.01200

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.3 0.4 0.6 0.4
Bipolar Disorder or Schizophrenia 0.2 0.4 0.8 -0.0 0.9
Depressed Affect (Nagel 2018) 0.0 0.1 0.1 -0.2 -0.4
Depression (Nagel 2018) 2.6 4.0 4.1 -2.0 1.9
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.0 0.6 -1.0
Neuroticism (Nagel 2018) 0.0 0.0 0.1 -0.2 -0.3
Schizophrenia (2018) 0.3 0.5 0.8 -0.6 0.9
Schizophrenia vs Biploar Disorder 0.4 0.5 0.9 0.2 -1.0
Worry (Nagel 2018) 0.2 0.4 0.6 -0.8 0.4
Alzheimer’s Disease (in mother) 0.8 1.0 1.1 -1.1 0.9
Alzheimer’s Disease (in father) 0.4 0.4 0.9 0.2 -0.9
Alzheimer’s Disease (including proxy) 0.2 0.2 0.4 -0.6 0.3
Crohns Disease (2017) 1.5 3.3 5.6 0.9 -2.4
Irritable Bowel Disease (IBD) 1.4 3.2 5.5 1.0 -2.4
Ulcerative Colitis (UC) 0.4 0.8 1.0 0.8 -1.0
Major Depression (MDD) 0.1 0.1 0.1 -0.1 0.3
Reaction Time 0.0 0.0 0.0 -0.0 -0.2
Verbal and Numeric Reasoning (VNR) 0.4 0.9 1.7 0.5 -1.3
Breast Cancer 0.5 1.2 1.3 -1.0 -1.1
Ovarian Cancer 1.4 1.9 2.0 1.4 -1.3
Prostate Cancer 3.0 4.2 5.5 1.7 -2.4
Age at First Birth 0.1 0.2 0.3 -0.2 -0.6
Bipolar Disorder (2011) 0.1 0.1 0.3 0.5 -0.1
Body Mass Index (BMI) (2010) 0.5 0.7 1.4 0.0 1.2
Coronary Artery Disease (CAD) 0.1 0.2 0.3 -0.6 0.2
Crohns Disease (2012) 0.8 1.4 2.6 0.3 -1.6
Mean Putamen Volume 0.4 0.5 0.9 -0.9 -0.2
Fasting Glucose 0.0 0.0 0.1 0.2 0.1
HbA1C 0.2 0.2 0.3 0.1 0.6
HDL Cholesterol 0.4 0.7 1.1 0.5 1.1
LDL Cholesterol 0.1 0.1 0.1 -0.4 0.3
Lupus 0.6 0.9 1.5 -1.2 0.6
Neuroticism (2016) 0.8 1.1 1.9 1.4 -0.6
Primary Biliary Cirrhosis 0.1 0.2 0.2 0.5 -0.4
Rheumatoid Arthritis 0.2 0.3 0.6 0.2 0.8
Schizophrenia (2014) 0.1 0.2 0.3 -0.3 0.6
Triglycerides 0.7 1.2 1.6 -0.9 -1.2
Type 2 Diabetes (T2D) (2012) 1.4 1.6 1.9 1.1 -1.4
Ulcerative Colitis 0.1 0.1 0.2 0.2 -0.5
Blood Eosinophil Count 0.1 1.1 1.7 -0.7 -1.3
Blood Platelet Count 0.0 0.2 0.3 -0.4 0.5
Blood Red Count 0.2 1.8 2.2 -1.2 1.5
Blood White Count 0.1 0.7 1.4 1.2 -0.2
Heel T-Score 1.3 10.0 13.5 -2.5 3.7
BMI 0.3 1.6 1.9 -1.1 1.4
Height 1.1 21.1 39.3 -6.3 -1.7
Waist Hip Ratio (WHR) 0.4 1.8 2.1 -1.5 1.2
Systolic Blood Pressure 8.0 40.1 54.5 -5.1 7.4
Smoking Status 2.3 5.5 6.1 -2.2 2.5
Allergy or Eczema 0.2 0.5 1.0 -0.2 1.0
Cardiovascular Disease 5.6 18.4 22.7 -3.8 4.8
Hypothyroidism (self reported) 0.1 0.3 0.5 0.3 -0.7
Respiratory disease 0.0 0.0 0.0 -0.1 -0.0
Type 2 Diabetes (T2D) (2018) 2.1 3.8 4.8 -1.7 2.2
Lung FEV1/FVC ratio 0.9 4.7 5.1 -2.0 2.3
Lung FVC 1.2 6.2 11.1 -1.2 3.3
Neuroticism 0.0 0.0 0.0 0.1 -0.0
Chronotype (morning person) 0.2 0.5 0.8 0.9 -0.5
Hair Pigment 0.0 0.6 0.9 0.6 -0.9
Tanning 0.0 0.2 0.4 0.1 0.7
Hand grip strength (left) 1.5 4.0 7.8 -2.8 0.5
Number of treatments/medications taken 1.1 1.9 2.3 -1.2 1.5
Average weekly spirits intake 0.3 0.4 0.7 0.2 0.8
Sensitivity / hurt feelings 0.6 0.9 1.3 1.1 -0.8
Frequency of depressed mood in last 2 weeks 2.3 3.2 4.8 -2.2 1.3
Hearing difficulty/problems: Yes 0.2 0.3 0.5 0.3 0.7
Relative age of first facial hair 0.1 0.1 0.3 0.5 -0.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.5 -0.7 -0.6
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 0.5 -0.0
Ever had hysterectomy (womb removed) 0.4 0.4 0.7 0.4 -0.8
Systolic blood pressure, automated reading 3.6 10.3 12.7 -2.8 3.6
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 3.8 -2.0 0.6
Angina 0.6 0.8 1.1 -0.7 1.1
Medication for hormone replacement therapy 0.4 0.5 0.6 0.6 -0.8
Vitamin and mineral supplements 0.0 0.1 0.1 -0.3 0.0
Supplements: Zinc 0.3 0.4 0.4 -0.7 0.5
Medication: Co-codamol 0.5 0.5 1.0 1.0 0.0
Medication: Metformin 0.8 1.1 1.9 -1.4 0.5
Diabetes (father) 1.1 1.4 2.7 1.6 0.3
Diabetes (mother) 0.2 0.3 0.6 -0.8 -0.0
Severe depression (siblings) 1.3 1.5 2.0 0.9 -1.4
Pack years adult smoking proportion 0.3 0.5 0.6 -0.6 0.8
Impedance of leg (right) 0.4 2.1 3.8 0.7 -1.9
Leg fat-free mass (left) 1.6 8.4 14.3 -3.8 1.6
Trunk fat percentage 0.1 0.2 0.4 -0.7 -0.0
Hand grip strength (right) 1.6 4.4 8.0 -2.8 0.9
Townsend deprivation index at recruitment 0.2 0.2 0.4 0.2 0.7
Current tobacco smoking 0.2 0.3 0.5 0.2 0.7
Average weekly fortified wine intake 0.1 0.1 0.1 0.3 -0.1
Maternal smoking around birth 0.1 0.1 0.3 -0.0 0.5
Fed-up feelings 0.1 0.2 0.3 -0.1 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 3.7 4.9 5.3 -2.3 2.1
Relative age voice broke 1.2 1.8 1.9 1.3 -1.4
Taking other prescription medications 0.5 0.8 1.2 -1.1 0.6
Age when periods started (menarche) 1.5 3.6 5.0 1.5 -2.2
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 3.7 1.3 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 1.6 -1.3 0.3
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 1.3 -1.2 0.7
Qualifications: CSEs or equivalent 0.1 0.2 0.2 -0.4 0.5
Serious illness, injury or assault to yourself 0.0 0.0 0.1 0.2 0.1
High blood pressure 7.8 21.9 22.8 -4.6 4.8
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.4 0.1 0.7
Multivitamins +/- minerals 0.5 0.6 1.1 -1.0 0.3
Stomach or abdominal pain in last month 0.3 0.4 0.6 0.3 -0.8
Supplements: Glucosamine 0.2 0.3 0.3 -0.6 -0.6
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.1 0.1 -0.3
Medication: Atenolol 3.4 4.3 7.7 -0.9 2.8
Medication: Levothyroxine sodium 0.3 0.4 0.8 -0.2 -0.9
Sitting height 1.9 13.2 24.7 -5.0 1.3
Chronic bronchitis/emphysema (father) 0.2 0.3 0.5 0.7 -0.3
High blood pressure (mother) 2.5 3.4 4.5 -1.6 2.1
Body mass index (BMI) 0.2 0.8 1.3 -1.1 0.6
Impedance of leg (left) 0.3 1.6 3.1 0.2 -1.8
Leg predicted mass (left) 1.5 8.2 13.8 -3.7 1.6
Trunk fat mass 0.5 2.1 4.2 -2.0 0.2
Waist circumference 0.3 1.0 1.9 -1.4 0.1
Number of incorrect matches in round 0.2 0.3 0.4 0.5 -0.6
Past tobacco smoking 5.5 10.1 11.0 3.3 -3.0
Alcohol usually taken with meals 0.0 0.0 0.0 0.1 -0.0
Nervous feelings 0.0 0.0 0.0 -0.0 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 2.1 -0.8 1.5
Hearing difficulty/problems with background noise 0.4 0.6 1.1 -0.3 1.1
Hair/balding pattern: Pattern 2 0.0 0.0 0.1 0.3 -0.1
Had menopause 0.7 0.8 0.9 0.9 -0.9
Had other major operations 1.5 1.9 3.7 0.0 -1.9
Forced vital capacity (FVC) 3.5 13.3 19.2 -4.4 2.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.2 -1.5 0.5
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.5 0.7 0.3
Qualifications: None of the above 0.0 0.0 0.0 0.2 0.1
Financial difficulties in last 2 years 0.5 0.7 0.8 -0.9 0.8
Mouth/teeth dental problems 0.2 0.2 0.4 0.7 0.2
Heart attack 2.8 3.5 4.5 -1.6 2.1
Allergy 0.4 1.0 1.7 0.4 -1.3
Pain all over the body in last month 0.3 0.3 0.4 0.6 -0.4
Diabetes (self-reported) 1.7 2.6 3.1 -1.8 1.4
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.1 0.3 -0.4
Medication: Ramipril 1.2 1.5 1.8 -1.4 1.1
Medication: Simvastatin 0.1 0.1 0.1 0.3 -0.3
Fluid intelligence score 0.1 0.1 0.2 0.1 -0.5
Illnesses of siblings 1.1 1.6 2.2 0.9 -1.5
Neuroticism score 0.0 0.0 0.1 0.2 -0.1
Weight 1.2 5.9 11.7 -3.4 0.4
Impedance of arm (right) 0.7 3.0 6.0 2.4 -0.3
Arm fat percentage (right) 0.0 0.2 0.2 -0.3 0.5
Trunk fat-free mass 2.4 13.5 26.6 -5.2 0.6
Hip circumference 0.4 1.9 3.7 -1.9 0.0
Time employed in main current job 0.7 0.8 1.3 1.2 -0.5
Alcohol intake versus 10 years previously 0.5 0.7 1.3 1.1 0.3
Father’s age at death 3.4 4.6 4.8 2.2 -2.1
Worrier / anxious feelings 0.4 0.8 1.3 -0.4 1.1
Frequency of tiredness / lethargy in last 2 weeks 5.5 8.9 11.0 -3.3 2.6
Falls in the last year 1.1 1.4 1.8 -1.0 1.3
Hair/balding pattern: Pattern 3 0.5 0.7 1.3 1.1 0.4
Number of live births 0.1 0.1 0.2 -0.1 0.4
Forced expiratory volume in 1-second (FEV1) 3.7 12.5 18.0 -4.2 2.6
Pulse rate 0.8 1.4 1.8 1.0 -1.3
Happiness 0.8 1.0 1.5 -1.2 0.7
Noisy workplace 0.1 0.1 0.2 0.4 -0.3
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.1 1.1 -0.4
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 1.5 -1.2 0.9
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 -0.5 0.2
Asthma 0.0 0.0 0.0 0.1 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.3 -0.1 -0.6
Medication: Cholesterol lowering 0.9 1.3 1.4 -1.2 1.1
Depression (self-reported) 0.7 0.8 1.1 -0.8 1.0
Medication: Lansoprazole 0.3 0.3 0.3 0.6 -0.6
Prospective memory result 1.1 1.3 1.5 -1.1 1.2
Lung cancer (father) 0.5 0.6 0.6 -0.7 0.8
Illnesses of mother 4.2 5.2 6.2 2.0 -2.5
Forced expiratory volume in 1-second (FEV1), Best measure 4.3 13.7 17.6 -4.2 3.1
Pulse wave Arterial Stiffness index 0.8 0.9 1.7 0.4 -1.3
Impedance of arm (left) 1.0 4.8 9.1 3.0 -0.7
Arm fat mass (right) 0.2 1.0 1.9 -1.4 0.3
Trunk predicted mass 2.3 13.2 26.1 -5.1 0.6
Standing height 1.4 13.5 26.7 -5.2 -0.6
Length of working week for main job 0.0 0.0 0.1 0.1 0.2
Exposure to tobacco smoke at home 3.9 4.4 4.6 -2.0 2.1
Breastfed as a baby 2.2 2.7 4.1 1.1 -2.0
Tense / ‘highly strung’ 0.5 0.8 0.9 -0.8 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 3.0 4.6 4.7 -2.1 2.2
Hair/balding pattern: Pattern 4 1.1 2.7 4.2 -2.0 1.1
Birth weight of first child 1.2 2.1 2.5 1.6 -1.3
Peak expiratory flow (PEF) 3.3 7.6 12.4 -3.5 1.7
Pulse wave reflection index 1.7 2.1 3.5 -1.9 0.9
Ever highly irritable/argumentative for 2 days 0.9 1.1 1.2 1.1 -1.0
Loud music exposure frequency 0.2 0.2 0.3 -0.6 0.4
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.4 -0.1 0.7
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 4.0 -2.0 0.7
Blood clot in the leg (DVT) 2.4 3.1 4.8 -2.2 1.2
Medication: Paracetamol 0.2 0.4 0.7 0.2 -0.9
Headache pain in last month 0.5 0.9 1.6 -1.3 -0.4
Medication for cholesterol, blood pressure or diabetes 2.2 3.7 4.4 1.8 -2.1
Glaucoma (self-reported) 0.7 0.8 1.6 0.0 1.3
Gout (self-reported) 0.6 0.8 1.2 -0.6 1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.5 -0.7 -0.3
Medication: Amlodipine 1.3 1.8 2.8 -0.9 1.7
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.3 0.5 -1.5
Birth weight 1.0 2.2 4.3 2.1 -0.3
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.4 0.6 0.6
High blood pressure (siblings) 2.6 3.8 6.2 -1.2 2.5
Forced vital capacity (FVC), Best measure 3.8 13.7 17.6 -4.2 3.1
Body fat percentage 0.1 0.5 0.9 -1.0 0.1
Leg fat percentage (right) 0.3 1.1 2.2 -1.5 0.1
Arm fat-free mass (right) 2.1 10.8 21.3 -4.6 0.5
Exposure to tobacco smoke outside home 1.2 1.6 2.7 -0.7 1.7
Comparative body size at age 10 0.7 1.8 2.5 -1.1 1.6
Number of full brothers 0.7 0.9 1.0 -0.9 1.0
Worry too long after embarrassment 1.1 1.9 2.0 1.3 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.4 1.8 -0.9 1.4
Wheeze or whistling in the chest in last year 0.1 0.1 0.2 0.1 -0.4
Number of children fathered 0.3 0.4 0.7 0.2 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.2 1.4 1.2 -1.0
Age at first live birth 0.0 0.1 0.1 -0.3 -0.1
Pulse wave peak to peak time 0.6 0.7 1.1 -0.5 1.1
Health satisfaction 1.5 2.0 2.0 -1.4 1.4
Shortness of breath walking on level ground 0.6 0.7 1.2 0.5 1.1
Qualifications: College or University degree 0.5 1.5 2.9 1.7 -0.4
Eye problems/disorders: None of the above 0.3 0.4 0.6 0.8 -0.4
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.7 -0.8 0.3
Emphysema/chronic bronchitis 0.6 0.6 1.2 0.2 1.1
Medication for pain relief, constipation, heartburn 0.4 0.8 1.4 1.2 -0.3
Neck or shoulder pain in last month 0.6 0.8 1.1 -1.0 0.8
Medication: Blood pressure 3.9 6.8 8.8 -2.2 3.0
Angina (self-reported) 0.4 0.5 0.8 -0.6 0.9
Migraine (self-reported) 0.4 0.5 0.5 -0.7 -0.7
Medication: Ibuprofen 0.1 0.1 0.1 0.3 -0.3
Medication: Allopurinol 0.1 0.1 0.2 0.1 0.4
Medication: Omeprazole 1.6 1.9 2.3 -1.2 1.5
Medication: Seretide 50 evohaler 1.2 1.4 2.3 -1.5 0.7
Mean time to correctly identify matches 0.1 0.2 0.5 0.1 -0.7
Heart disease (mother) 1.1 1.4 1.6 -1.3 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 1.4 1.2 -0.9
Whole body fat mass 0.7 3.0 5.8 -2.4 0.4
Leg fat mass (right) 1.0 3.9 7.6 -2.8 0.5
Arm predicted mass (right) 2.0 10.1 20.0 -4.5 0.4
Pulse rate, automated reading 0.4 1.3 1.5 1.2 -1.1
Alcohol intake frequency. 0.1 0.2 0.2 0.4 0.5
Comparative height size at age 10 1.1 6.2 12.3 -3.5 0.4
Number of full sisters 1.4 1.7 3.3 0.1 -1.8
Suffer from ‘nerves’ 0.4 0.6 1.1 -1.0 -0.3
Overall health rating 0.3 0.6 0.8 -0.9 0.6
Chest pain or discomfort 0.8 1.2 1.6 -0.9 1.3
Had major operations 9.3 10.9 13.5 -2.9 3.7
Age at last live birth 0.1 0.1 0.1 0.4 -0.3
Family relationship satisfaction 0.1 0.1 0.2 0.5 -0.1
Leg pain on walking 0.6 0.7 1.1 0.6 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.6 2.0 2.5 -1.2 1.6
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.0 -1.0 0.2
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 -0.2 -0.5
Medication: Aspirin 2.9 3.9 5.2 -2.3 1.6
Supplements: Vitamin C 0.6 0.7 1.2 1.1 -0.4
Knee pain experienced in last month 5.6 8.8 9.0 -2.9 3.0
Hypertension (Self-reported) 7.7 21.4 22.7 -4.5 4.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.5 -0.7 0.5
Illnesses of father: Heart disease 0.8 1.1 1.2 -1.1 1.0
Illnesses of siblings: Diabetes 1.0 1.2 2.1 -0.5 1.4
Smoking status: Previous 5.2 7.8 9.7 -3.1 2.4
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.0 -1.4 0.9
Whole body fat-free mass 2.2 12.6 23.9 -4.9 1.1
Leg fat-free mass (right) 1.7 9.0 15.3 -3.9 1.6
Arm fat percentage (left) 0.0 0.0 0.0 0.1 0.2
Average weekly red wine intake 1.1 1.6 1.8 1.3 -1.2
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.7 0.5 -1.3
Mood swings 0.0 0.1 0.1 0.3 0.3
Loneliness, isolation 0.3 0.4 0.6 -0.8 0.3
Long-standing illness, disability or infirmity 0.8 1.2 1.4 -1.0 1.2
Ever had bowel cancer screening 1.1 1.2 1.4 1.0 -1.2
Diabetes diagnosed by doctor 1.5 2.5 2.7 -1.5 1.6
Ever had stillbirth, spontaneous miscarriage or termination 4.4 4.7 7.7 -2.8 1.3
Friendships satisfaction 0.3 0.4 0.7 -0.3 -0.9
Qualifications: nursing, teaching 2.3 3.6 5.1 -2.3 1.4
Commuting to job workplace: Walk 0.5 0.5 0.6 0.7 -0.8
Eye problems/disorders: Cataract 2.8 3.2 3.8 -1.6 1.9
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 0.3 -0.7
Medication for cholesterol 1.1 1.7 1.9 1.4 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 1.7 -1.3 0.5
Back pain experienced in last month 0.6 0.9 1.6 0.3 -1.3
Mineral and other dietary supplements 0.2 0.2 0.3 0.6 0.3
Breast cancer (self-reported) 0.1 0.2 0.3 0.0 0.6
Asthma (self-reported) 0.0 0.0 0.0 0.1 -0.1
Osteoporosis (self-reported) 1.1 1.4 2.0 1.4 -0.9
Osteoarthritis (self-reported) 0.3 0.3 0.4 -0.7 -0.5
Medication: Aspirin 2.1 2.7 3.9 -2.0 1.2
Medication: Gliclazide 2.5 2.8 3.5 -1.9 1.5
Illnesses of father: None of the above (group 1) 0.3 0.3 0.6 -0.8 0.1
Smoking status: Current 0.1 0.2 0.2 0.3 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.7 7.8 9.3 -2.5 3.0
Whole body water mass 2.0 11.7 22.2 -4.7 1.1
Leg predicted mass (right) 1.7 9.2 15.5 -3.9 1.7
Arm fat mass (left) 0.2 0.9 1.7 -1.3 0.2
Number of self-reported non-cancer illnesses 1.4 2.4 3.4 -1.8 1.2
Average weekly champagne plus white wine intake 0.1 0.2 0.3 -0.5 0.3
Miserableness 1.0 1.7 2.8 -0.8 1.7
Guilty feelings 1.2 1.8 1.9 1.3 -1.4
Wears glasses or contact lenses 1.5 1.7 2.2 1.5 -1.1
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.5 -0.2
Hearing aid user 0.2 0.2 0.5 0.7 0.1
Mother’s age at death 1.5 1.8 2.9 0.9 -1.7
Financial situation satisfaction 0.4 0.5 0.8 -0.5 -0.9
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.3 0.6 0.1
Commuting to job workplace: Public transport 0.1 0.2 0.3 0.5 0.1
Eye problems/disorders: Glaucoma 0.2 0.2 0.2 0.4 0.5
Medication: Blood pressure 9.2 17.5 20.1 -3.9 4.5
Pain type(s) experienced in last month: Hip pain 1.7 2.1 3.1 1.1 -1.8
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.2 0.3 -0.4
High cholesterol (Self-reported) 0.0 0.0 0.1 -0.1 0.3
Medication: Bendroflumethiazide 2.0 3.0 5.3 -0.8 2.3
Medication: Paracetamol 0.8 1.2 1.6 0.9 -1.3
Medication: Lisinopril 2.8 3.7 6.0 -1.2 2.4
Medication: Atorvastatin 2.3 2.8 3.5 -1.9 1.5
Illnesses of father: High blood pressure 0.9 1.2 2.3 -0.1 1.5
Alcohol drinker status: Never 0.0 0.0 0.1 -0.1 0.3
Ever smoked 4.3 7.5 8.3 -2.6 2.9
Basal metabolic rate 2.1 11.4 21.8 -4.7 1.0
Leg fat percentage (left) 0.4 1.5 2.9 -1.7 -0.0
Arm fat-free mass (left) 2.3 11.6 22.7 -4.8 0.7
Number of operations (self-reported) 0.9 1.4 2.1 -1.5 0.8
Average weekly beer plus cider intake 0.2 0.3 0.5 -0.7 0.2
Irritability 0.3 0.4 0.9 0.0 0.9
Risk taking 1.1 1.6 1.7 -1.3 1.2
Ever had prostate specific antigen (PSA) test 1.6 1.9 3.6 -1.9 0.4
Fractured/broken bones in last 5 years 0.9 1.2 2.2 0.4 -1.5
Age started oral contraceptive pill 0.5 0.7 0.7 0.8 -0.8
Diastolic blood pressure, automated reading 1.8 5.5 5.5 -2.3 2.4
Ever depressed for a whole week 0.9 1.1 1.7 0.7 1.3
Unable to work because of sickness or disability 2.2 2.9 4.2 -2.0 1.3
Commuting to job workplace: Cycle 0.6 0.7 1.3 1.2 -0.3
Myopia 0.2 0.3 0.4 0.6 -0.4
Vascular/heart problems diagnosed by doctor 8.8 24.1 24.3 4.9 -4.9
Cholesterol lowering medication 0.2 0.3 0.5 -0.7 0.3
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 2.0 -1.2 1.4
Pain experienced in last month 1.0 1.6 3.2 1.8 -0.3
Supplements: Calcium 0.5 0.6 1.0 -1.0 -0.4
Basal cell carcinoma (self-reported) 1.4 1.7 2.3 -1.5 1.0
Heart attack/myocardial infarction (self-reported) 2.3 3.0 3.6 -1.6 1.9
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 4.4 -2.1 1.0
Heart disease (siblings) 0.1 0.2 0.4 -0.6 -0.1
Alcohol drinker status: Previous 4.5 5.1 6.2 -2.0 2.5
Pack years of smoking 0.0 0.1 0.1 -0.1 0.3
Impedance of whole body 0.4 2.2 3.4 1.9 -1.0
Leg fat mass (left) 1.1 4.1 8.0 -2.8 0.5
Arm predicted mass (left) 2.3 11.7 22.8 -4.8 0.7