Hub : Genes

OBSCN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1430	0.0330	0.0e+00	0.153	0.151	0.176	0.159	0.173	3.9e-18	6.5e-18	7.2e-21	7.1e-19	1.6e-20
2	GTEx	Brain Cortex	0.2640	0.1080	4.5e-03	0.041	NA	0.074	NA	0.115	2.7e-02	NA	4.5e-03	NA	4.5e-04
3	GTEx	Brain Frontal Cortex BA9	0.2667	0.1060	7.7e-03	-0.004	NA	-0.010	NA	0.002	4.4e-01	NA	7.2e-01	NA	2.9e-01
4	GTEx	Cells Transformed fibroblasts	0.2840	0.0490	0.0e+00	0.348	NA	0.365	NA	0.374	5.6e-27	NA	1.4e-28	NA	2.1e-29
5	GTEx	Esophagus Mucosa	0.2980	0.0570	0.0e+00	0.369	NA	0.357	NA	0.371	8.9e-26	NA	7.6e-25	NA	5.1e-26
6	GTEx	Nerve Tibial	0.1665	0.0489	1.5e-06	0.083	NA	0.093	NA	0.094	1.7e-06	NA	4.0e-07	NA	3.6e-07
7	GTEx	Skin Not Sun Exposed Suprapubic	0.4130	0.0780	3.4e-13	0.312	NA	0.244	NA	0.285	1.3e-17	NA	1.3e-13	NA	5.9e-16
8	GTEx	Skin Sun Exposed Lower leg	0.3850	0.0640	0.0e+00	0.209	NA	0.233	NA	0.248	3.6e-17	NA	3.7e-19	NA	1.8e-20
9	ROSMAP	Brain Pre-frontal Cortex	0.3164	0.0509	0.0e+00	0.182	0.255	0.248	0.265	0.266	9.1e-23	1.3e-32	1.3e-31	6.2e-34	3.5e-34
10	YFS	Blood	0.0267	0.0092	9.8e-07	0.030	0.023	0.028	0.026	0.030	3.6e-10	3.9e-08	1.6e-09	4.0e-09	3.7e-10
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0728	0.0276	1.8e-10	0.094	0.100	0.089	NA	0.091	9.4e-11	2.8e-11	3.4e-10	NA	2.1e-10
12	TCGA	Lung Squamous Cell Carcinoma	0.0835	0.0500	5.4e-07	0.064	0.045	0.049	NA	0.059	7.9e-08	6.3e-06	2.9e-06	NA	2.7e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.3	0.5	0.9	0.8	0.9	-0.4	0.5	-0.6	0.8	-0.4	-0.7	0.6	-1.0	-0.7	-0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	2.4	0.8	0.6	-0.2	0.9	-1.1	0.8	-1.0	-1.2	0.6	-1.6	-1.1	-1.0
Depressed Affect (Nagel 2018)	0.2	0.4	2.4	-0.6	-1.5	-0.6	-0.6	0.5	-0.4	0.3	0.3	-0.5	0.8	0.2	0.6
Depression (Nagel 2018)	1.6	2.4	4.2	1.6	0.3	-0.2	1.9	-1.9	0.6	-1.9	-1.8	1.2	-1.5	-2.0	-1.7
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.3	-1.4	0.1	-1.1	-1.1	1.1	-1.5	1.4	1.3	-1.4	1.5	1.2	1.1
Neuroticism (Nagel 2018)	0.1	0.2	1.3	-0.3	-0.6	-0.2	-0.3	0.3	-0.1	0.3	0.4	-0.2	1.1	0.1	0.4
Schizophrenia (2018)	0.3	0.6	1.5	0.4	-0.1	0.1	0.7	-0.9	0.4	-1.0	-1.0	0.3	-1.2	-0.8	-0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	1.5	-0.2	-0.4	0.8	-0.7	0.5	1.2	0.7	0.5	0.1	0.0	0.6	0.8
Worry (Nagel 2018)	0.3	0.7	2.8	0.8	1.7	0.3	0.6	-0.5	1.2	-0.3	-0.2	1.2	0.5	-0.5	-0.6
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	0.7	0.4	0.6	0.9	-0.9	0.4	-1.1	-0.8	0.7	-0.8	-0.9	-1.0
Alzheimer’s Disease (in father)	0.4	0.4	0.8	-0.3	0.3	0.3	-0.9	0.7	0.3	0.8	0.8	-0.5	0.8	0.9	0.8
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	0.6	0.8	0.7	0.5	-0.5	0.7	-0.6	-0.5	0.5	-0.5	-0.2	-0.4
Crohns Disease (2017)	1.4	3.2	5.8	-1.6	-0.9	0.9	-2.3	2.2	-0.3	2.1	2.0	-1.5	1.4	2.4	2.3
Irritable Bowel Disease (IBD)	1.5	3.6	5.3	-1.8	-1.6	1.8	-2.1	2.1	-1.0	2.3	2.3	-1.3	1.6	2.2	2.2
Ulcerative Colitis (UC)	0.7	1.4	4.2	-1.2	-2.0	0.9	-0.9	0.9	-1.5	1.3	1.2	-0.8	0.9	0.8	1.0
Major Depression (MDD)	0.2	0.2	1.0	0.3	1.0	-0.0	0.3	-0.4	0.7	0.1	-0.1	0.4	-0.2	-0.3	-0.3
Reaction Time	0.1	0.2	0.5	0.4	-0.0	-0.7	0.1	-0.0	-0.2	-0.2	0.2	0.6	0.7	-0.3	0.0
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.0	-2.0	-0.4	-0.5	-1.6	1.6	-1.4	1.7	1.4	-2.0	1.4	1.6	1.6
Breast Cancer	0.7	1.6	5.5	1.1	1.9	2.4	-0.1	0.3	1.7	0.4	0.8	1.6	1.3	0.4	0.4
Ovarian Cancer	2.5	3.4	8.7	-2.1	-3.0	-1.4	-1.9	1.7	-1.4	1.4	1.4	-2.7	1.1	1.3	1.6
Prostate Cancer	3.4	4.8	6.9	-2.3	-2.4	-0.2	-2.6	2.6	-1.6	2.0	2.3	-1.9	2.6	2.1	2.5
Age at First Birth	0.6	0.8	5.5	-0.5	-2.4	0.6	-0.9	0.9	0.1	0.6	0.6	-0.5	0.7	0.4	0.8
Bipolar Disorder (2011)	0.1	0.1	0.4	-0.4	-0.5	-0.2	-0.2	0.1	-0.4	0.1	-0.1	-0.6	-0.6	-0.2	-0.0
Body Mass Index (BMI) (2010)	0.8	1.1	2.6	1.1	-0.1	-1.1	1.3	-1.2	0.4	-1.0	-1.1	0.6	-0.8	-1.6	-1.4
Coronary Artery Disease (CAD)	0.4	0.5	2.1	-0.5	-1.3	-1.5	-0.0	-0.3	-0.8	0.1	-0.4	-0.8	-0.4	-0.2	0.3
Crohns Disease (2012)	0.6	0.9	2.3	-0.7	0.3	0.4	-1.4	1.2	0.6	1.0	0.9	-0.7	0.4	1.5	1.4
Mean Putamen Volume	0.0	0.0	0.2	0.4	0.3	-0.2	0.2	-0.0	0.2	-0.1	-0.1	0.2	0.3	-0.2	0.1
Fasting Glucose	0.3	0.4	1.6	-0.1	-1.3	-0.4	-0.6	0.3	0.3	-1.2	-0.1	-0.4	0.5	-0.3	0.3
HbA1C	0.6	0.7	1.5	0.9	0.0	-0.0	0.8	-1.0	1.0	-0.0	-0.7	1.2	-0.9	-1.0	-1.0
HDL Cholesterol	0.2	0.3	1.1	-0.4	0.3	0.2	0.6	-0.6	-1.0	-0.2	-0.5	-1.0	-0.6	0.1	-0.7
LDL Cholesterol	0.1	0.2	0.5	0.5	-0.2	-0.5	0.5	-0.6	0.7	-0.4	-0.4	0.4	-0.1	-0.7	-0.5
Lupus	0.9	1.3	3.4	1.5	1.2	1.8	0.9	-1.0	1.6	-0.2	-0.5	1.5	-0.3	-0.7	-1.0
Neuroticism (2016)	0.7	1.0	3.2	-1.4	-0.9	-1.0	-0.4	0.5	-1.8	1.0	0.9	-1.2	0.9	0.6	0.3
Primary Biliary Cirrhosis	0.2	0.2	0.4	-0.4	-0.2	0.5	-0.6	0.6	-0.4	0.4	0.5	0.1	0.6	0.6	0.7
Rheumatoid Arthritis	0.3	0.3	0.9	0.5	-0.6	-0.2	0.6	-0.6	0.3	-0.8	-0.9	0.1	-0.9	-0.5	-0.4
Schizophrenia (2014)	0.3	0.6	1.6	0.5	0.1	0.0	0.5	-0.8	1.2	-0.6	-0.9	0.4	-1.3	-0.9	-0.6
Triglycerides	0.8	1.3	5.8	0.4	1.0	2.4	-0.6	0.8	0.6	0.6	1.0	1.4	1.2	1.1	1.1
Type 2 Diabetes (T2D) (2012)	1.7	2.0	2.9	-1.7	0.1	-0.5	-1.4	1.6	-1.2	1.7	1.6	-1.5	1.5	1.5	1.5
Ulcerative Colitis	0.2	0.4	2.4	0.2	-1.6	0.7	0.2	-0.3	0.1	0.6	0.3	0.7	0.3	-0.5	-0.1
Blood Eosinophil Count	0.1	1.1	3.0	-0.8	-1.7	-0.9	-1.2	1.0	-0.1	1.0	0.8	-1.4	0.5	0.7	1.5
Blood Platelet Count	0.1	0.9	2.2	1.5	1.3	-0.2	0.9	-0.9	1.4	-0.6	-0.4	1.1	0.0	-0.9	-0.7
Blood Red Count	0.3	3.0	9.8	2.1	3.1	0.2	1.8	-1.7	2.2	-1.6	-1.4	1.6	-0.9	-1.3	-1.4
Blood White Count	0.3	2.3	11.9	-1.3	-1.7	-3.5	-0.6	0.5	-2.2	0.7	0.2	-2.3	0.1	0.1	0.5
Heel T-Score	1.3	10.1	14.7	3.2	1.7	0.7	3.8	-3.7	1.6	-3.7	-3.6	3.4	-3.7	-3.6	-3.4
BMI	0.4	2.5	6.4	2.0	1.0	-2.1	1.2	-1.4	2.5	-1.4	-1.6	0.7	-1.0	-1.7	-1.3
Height	0.4	6.9	31.2	2.5	2.4	5.6	-0.1	0.3	1.9	-0.6	0.7	5.2	2.4	0.7	1.1
Waist Hip Ratio (WHR)	0.2	0.8	3.5	0.1	0.1	0.3	0.8	-0.8	-1.1	-1.2	-1.2	0.1	-1.9	-0.7	-0.8
Systolic Blood Pressure	6.8	34.0	49.1	5.7	5.3	-1.2	6.9	-6.9	2.2	-7.0	-6.8	4.4	-6.2	-6.7	-7.0
Smoking Status	1.7	4.1	8.0	1.8	2.8	0.7	2.3	-2.3	0.8	-2.5	-2.2	1.3	-2.3	-1.6	-2.2
Allergy or Eczema	0.2	0.4	1.5	0.4	-1.2	-0.2	0.8	-0.6	-0.6	-0.9	-0.7	-0.1	-0.4	-0.6	-0.6
Cardiovascular Disease	3.3	10.9	19.7	3.0	2.6	-1.9	4.0	-3.9	0.3	-4.4	-4.0	2.2	-3.1	-3.9	-3.9
Hypothyroidism (self reported)	0.2	0.6	3.4	0.8	0.2	-0.1	-0.1	0.2	1.8	0.2	0.4	1.3	0.7	-0.1	0.3
Respiratory disease	0.1	0.2	1.0	0.5	0.0	0.6	0.1	-0.2	1.0	0.1	-0.1	0.6	-0.2	-0.6	-0.4
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.0	-0.1	-1.1	-1.4	1.2	-1.3	-1.8	-1.6	-1.8	-1.4	-2.0	-1.2	-1.2
Lung FEV1/FVC ratio	0.9	4.3	6.9	2.6	1.2	-0.1	2.6	-2.4	0.6	-2.6	-2.2	2.3	-1.5	-2.3	-2.4
Lung FVC	1.1	5.8	17.6	2.0	4.2	-0.5	2.9	-2.7	1.2	-2.6	-2.3	1.6	-1.7	-2.0	-3.0
Neuroticism	0.0	0.1	0.5	-0.3	-0.5	-0.0	-0.2	0.2	-0.1	0.4	0.3	-0.1	0.7	-0.1	0.0
Chronotype (morning person)	0.2	0.5	1.1	-0.8	0.9	0.6	-0.9	1.0	0.1	0.5	0.7	-0.5	0.4	1.1	0.8
Hair Pigment	0.1	1.8	3.9	-2.0	-1.3	-0.1	-1.6	1.3	-1.6	1.1	1.0	-1.9	0.5	1.4	1.2
Tanning	0.0	0.2	0.5	-0.2	0.7	0.0	0.1	-0.3	-0.3	-0.1	-0.4	-0.7	-0.7	0.0	-0.4
Hand grip strength (left)	1.0	2.6	10.2	2.1	3.2	1.1	0.6	-0.6	2.7	-1.2	-0.9	2.2	-0.5	-0.3	-0.0
Number of treatments/medications taken	0.6	1.1	2.0	1.0	0.4	-0.2	1.4	-1.3	-0.2	-1.3	-1.1	1.0	-0.6	-1.4	-1.3
Average weekly spirits intake	0.3	0.3	0.7	-0.2	-0.7	-0.8	0.4	-0.5	-0.5	-0.5	-0.6	-0.3	-0.7	-0.6	-0.7
Sensitivity / hurt feelings	1.1	1.9	4.2	-1.8	-2.1	0.6	-1.3	1.2	-1.6	1.4	1.1	-1.8	0.6	1.1	1.1
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.2	1.2	0.5	0.6	1.4	-1.5	0.2	-1.3	-1.4	1.0	-1.1	-1.4	-1.3
Hearing difficulty/problems: Yes	0.4	0.6	1.3	0.2	-1.1	-1.1	0.6	-0.6	0.0	-0.4	-0.8	-0.5	-1.1	-0.8	-0.7
Relative age of first facial hair	0.3	0.7	2.9	0.6	1.7	1.7	0.2	-0.1	1.0	0.2	0.3	1.1	0.1	0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.0	-0.1	-1.4	-0.5	-0.6	0.5	-0.1	0.4	0.6	0.1	1.3	0.1	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.6	-0.9	1.3	0.8	-0.4	0.4	-0.2	0.6	0.4	-0.6	0.3	0.8	0.4
Ever had hysterectomy (womb removed)	0.9	1.1	2.6	-1.0	1.1	0.6	-1.1	1.1	-0.5	1.0	0.8	-1.4	0.6	1.6	0.8
Systolic blood pressure, automated reading	2.9	8.3	17.6	2.8	4.2	-1.0	3.1	-3.2	1.6	-3.3	-3.3	1.9	-2.9	-2.9	-3.1
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.3	1.6	-0.1	0.6	1.0	-1.1	1.3	-1.0	-0.9	1.8	-0.6	-1.5	-0.9
Angina	0.4	0.6	1.4	0.4	-1.2	-0.5	0.9	-0.8	-0.4	-0.6	-0.7	-0.1	-0.2	-1.2	-1.0
Medication for hormone replacement therapy	1.2	1.3	2.7	-1.5	-0.8	0.0	-1.2	1.1	-1.1	0.9	1.0	-1.6	0.9	1.3	1.2
Vitamin and mineral supplements	0.1	0.1	0.7	-0.0	-0.4	-0.8	0.4	-0.3	-0.4	0.0	-0.1	-0.1	0.1	-0.1	-0.4
Supplements: Zinc	0.5	0.5	3.9	0.4	0.4	2.0	0.3	-0.2	-0.3	-0.7	-0.1	0.9	0.1	-0.4	-0.2
Medication: Co-codamol	0.6	0.7	3.1	-0.7	-1.2	-1.8	-0.2	0.2	-1.3	0.3	0.1	-1.0	0.2	0.0	0.0
Medication: Metformin	0.3	0.4	1.4	-0.4	-0.6	0.2	-0.0	-0.2	-1.2	-0.5	-0.6	-1.1	-1.1	-0.1	0.0
Diabetes (father)	0.8	1.0	10.3	-0.2	0.6	-3.2	0.3	-0.2	-0.7	-0.1	-0.1	-0.2	0.1	-0.6	-0.4
Diabetes (mother)	0.1	0.2	0.8	-0.1	-0.9	0.2	-0.4	0.4	-0.4	-0.3	0.1	-0.4	0.5	0.1	0.6
Severe depression (siblings)	2.1	2.3	3.6	-1.8	-1.4	-0.3	-1.6	1.5	-1.3	1.9	1.6	-1.8	1.4	1.4	1.6
Pack years adult smoking proportion	0.3	0.5	0.9	0.8	0.9	-0.7	0.8	-0.7	0.4	-0.8	-0.4	0.5	-0.2	-0.6	-0.9
Impedance of leg (right)	0.7	3.5	15.2	-1.9	-3.9	0.1	-1.6	1.7	-2.5	1.7	1.5	-0.7	1.1	1.3	1.9
Leg fat-free mass (left)	1.0	5.6	11.8	3.4	3.3	0.6	1.9	-2.0	3.3	-2.5	-2.1	2.8	-1.1	-1.7	-1.6
Trunk fat percentage	0.1	0.4	3.5	0.2	-1.9	-0.9	-0.1	0.0	-0.5	-0.3	-0.1	-0.2	0.2	-0.4	0.2
Hand grip strength (right)	1.1	3.1	9.5	2.3	3.1	0.5	1.1	-1.0	2.9	-1.6	-1.4	2.3	-0.8	-0.9	-0.5
Townsend deprivation index at recruitment	0.3	0.4	1.8	0.4	1.3	-1.0	0.6	-0.6	0.6	-0.2	-0.3	0.1	-0.3	-0.6	-0.8
Current tobacco smoking	0.2	0.3	0.9	0.2	0.5	-1.0	0.5	-0.5	-0.1	-0.7	-0.5	-0.3	-0.5	-0.3	-0.4
Average weekly fortified wine intake	0.2	0.2	1.7	-0.3	-0.1	1.3	-0.2	0.1	-0.1	0.5	0.3	0.0	0.0	-0.0	0.0
Maternal smoking around birth	0.2	0.2	2.4	-0.1	-0.1	1.6	-0.0	0.1	-0.1	-0.3	0.0	-0.4	-0.1	0.2	-0.0
Fed-up feelings	0.3	0.5	2.1	-0.7	-1.4	-0.7	-0.6	0.5	-1.1	0.5	0.3	-0.7	0.3	0.4	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	6.6	2.4	1.2	-0.4	2.4	-2.4	1.4	-2.1	-2.1	2.3	-1.6	-2.6	-2.2
Relative age voice broke	1.4	2.1	3.7	-1.7	0.6	0.6	-1.5	1.6	-0.8	1.8	1.7	-1.4	1.5	1.9	1.3
Taking other prescription medications	0.2	0.3	0.9	0.7	-0.5	-0.6	0.6	-0.6	-0.1	-0.6	-0.4	0.6	0.1	-1.0	-0.5
Age when periods started (menarche)	2.0	4.9	9.3	-2.1	1.3	2.6	-2.2	2.4	-1.1	2.4	2.7	-0.9	2.4	3.1	2.3
Bilateral oophorectomy (both ovaries removed)	3.0	3.5	5.6	-1.8	0.4	1.6	-2.2	2.1	-0.9	2.2	2.3	-1.3	2.4	2.3	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	3.0	1.1	-0.5	1.4	0.2	-0.3	1.2	-0.9	-0.6	1.7	-0.5	-0.7	0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.6	-0.1	-0.4	0.7	-0.7	0.7	-0.7	-0.9	0.4	-0.9	-0.7	-0.4
Qualifications: CSEs or equivalent	1.3	1.7	4.6	1.9	1.0	-0.3	1.1	-1.2	2.2	-0.8	-1.0	1.9	-0.6	-1.4	-1.0
Serious illness, injury or assault to yourself	0.1	0.2	1.1	0.1	0.2	-1.1	0.1	0.0	-0.3	0.2	0.2	-0.2	0.6	-0.2	-0.2
High blood pressure	3.9	10.8	18.9	3.2	3.1	0.5	3.9	-3.9	0.8	-4.3	-3.9	2.6	-3.1	-3.7	-3.9
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.2	0.4	-1.1	0.5	0.6	-0.4	-0.2	-0.6	-0.4	0.2	-0.3	-0.6	-0.5
Multivitamins +/- minerals	0.5	0.6	1.9	0.9	1.0	1.4	0.2	-0.2	1.1	-0.6	-0.4	1.0	-0.5	-0.4	-0.2
Stomach or abdominal pain in last month	0.3	0.4	1.2	0.3	0.9	0.5	-0.5	0.6	0.4	0.6	0.7	0.3	1.1	0.6	0.6
Supplements: Glucosamine	0.3	0.3	1.0	-0.4	-0.3	0.8	-0.8	0.5	1.0	0.2	-0.0	-0.4	-0.7	0.3	0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.7	-0.0	1.6	1.4	-0.3	0.3	0.3	0.0	0.1	0.4	-0.1	0.8	0.3
Medication: Atenolol	2.5	3.2	5.4	0.7	-0.0	-2.3	2.0	-2.0	-1.3	-2.1	-2.2	-0.4	-1.7	-2.3	-2.2
Medication: Levothyroxine sodium	0.3	0.5	1.8	0.2	0.1	1.2	-0.6	0.6	1.4	0.5	0.6	0.7	0.5	0.5	0.8
Sitting height	0.8	6.0	19.4	3.3	3.0	3.2	2.0	-1.7	1.7	-2.4	-1.6	4.4	0.0	-1.5	-1.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.4	0.2	0.0	-0.3	0.2	0.1	0.4	0.5	-0.0	0.6	0.3	0.3
High blood pressure (mother)	1.9	2.7	5.0	1.8	0.3	-1.0	1.9	-2.0	0.9	-2.1	-1.9	1.1	-1.6	-2.2	-1.8
Body mass index (BMI)	0.2	0.9	2.8	1.2	0.4	-1.6	0.5	-0.7	1.7	-0.8	-0.9	-0.1	-0.5	-0.8	-0.5
Impedance of leg (left)	0.5	2.4	13.4	-1.3	-3.7	0.3	-1.3	1.3	-1.6	1.4	1.2	-0.2	0.9	0.9	1.6
Leg predicted mass (left)	1.1	5.6	11.8	3.4	3.2	0.6	1.9	-2.0	3.3	-2.5	-2.2	2.8	-1.2	-1.8	-1.6
Trunk fat mass	0.1	0.4	1.6	1.3	-0.4	-0.3	0.4	-0.4	0.7	-0.8	-0.6	0.9	0.1	-0.6	-0.1
Waist circumference	0.0	0.1	0.6	0.6	-0.1	-0.7	-0.0	-0.2	0.5	-0.4	-0.5	-0.1	-0.1	-0.4	0.1
Number of incorrect matches in round	0.4	0.7	3.3	-0.9	-1.8	0.1	-0.6	0.5	-1.2	0.7	0.5	-0.6	0.4	0.5	0.8
Past tobacco smoking	3.2	6.0	9.0	-2.3	-2.6	-1.1	-2.9	2.8	-1.1	3.0	2.8	-1.9	2.8	2.3	2.8
Alcohol usually taken with meals	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.2	0.3	-0.3	0.1	-0.0	-0.2	-0.3	0.2	0.1
Nervous feelings	0.8	1.6	5.8	1.4	2.4	1.0	0.9	-0.7	1.6	-0.2	-0.1	2.2	0.5	-0.7	-0.9
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	4.1	1.3	-0.6	-1.1	1.6	-1.6	0.6	-1.3	-1.7	0.9	-1.2	-2.0	-1.7
Hearing difficulty/problems with background noise	0.5	0.8	1.9	0.4	-1.1	-0.3	0.9	-0.9	0.3	-0.7	-1.1	0.1	-1.4	-1.1	-0.9
Hair/balding pattern: Pattern 2	0.2	0.3	2.1	0.1	-0.5	-1.4	-0.2	0.1	0.8	-0.3	-0.2	0.1	-0.0	-0.4	0.3
Had menopause	1.0	1.3	2.7	-1.6	-0.6	0.8	-1.2	1.1	-1.4	1.2	1.0	-1.2	0.4	1.3	1.2
Had other major operations	3.2	3.9	5.7	-2.3	-0.5	1.6	-2.3	2.2	-1.3	2.1	2.1	-1.8	1.8	2.4	2.3
Forced vital capacity (FVC)	2.6	10.1	19.2	4.1	3.5	0.7	3.5	-3.2	3.0	-3.4	-2.9	4.4	-1.8	-2.8	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.5	1.1	-0.4	0.7	0.4	-0.4	0.6	-0.9	-0.7	1.2	-0.3	-0.7	-0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.5	-0.4	0.2	-0.2	-0.1	0.1	-0.7	0.1	-0.0	-0.4	-0.1	0.1	-0.1
Qualifications: None of the above	0.1	0.3	0.6	0.6	0.7	-0.5	0.5	-0.5	0.7	-0.2	-0.1	0.7	0.3	-0.5	-0.6
Financial difficulties in last 2 years	0.6	0.8	2.0	0.7	0.1	0.6	0.9	-1.1	0.5	-0.8	-1.0	0.8	-1.4	-1.0	-1.0
Mouth/teeth dental problems	0.4	0.6	2.8	-1.2	0.1	-0.6	-0.4	0.3	-1.7	-0.1	0.2	-1.3	0.5	0.7	0.2
Heart attack	1.5	1.9	4.9	0.6	-0.2	-2.2	1.5	-1.5	-0.9	-1.6	-1.5	-0.6	-0.8	-1.5	-1.9
Allergy	0.3	0.7	1.2	-0.6	0.7	-1.0	-0.9	0.9	0.2	1.1	0.9	-0.2	1.0	1.1	1.0
Pain all over the body in last month	0.4	0.5	1.8	-0.5	-1.1	-1.4	-0.2	0.1	-0.6	0.7	0.4	-1.1	0.4	-0.1	0.0
Diabetes (self-reported)	0.7	1.1	2.3	-0.1	-1.5	-0.6	0.8	-0.9	-1.4	-1.0	-1.1	-1.0	-1.2	-1.1	-1.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.8	-0.1	-0.2	0.7	-0.4	0.4	0.9	0.3	0.3	-0.4	0.1	0.3	0.4
Medication: Ramipril	0.6	0.8	2.2	0.9	1.3	1.5	0.7	-0.5	0.1	-1.3	-0.6	1.1	-0.2	-0.2	-0.5
Medication: Simvastatin	1.0	1.5	5.0	-1.7	0.7	-1.0	-0.9	0.9	-2.2	0.9	0.9	-1.7	1.0	0.9	0.7
Fluid intelligence score	0.3	0.6	1.9	-1.0	-0.4	-0.5	-0.7	0.6	-0.8	0.8	0.5	-1.4	0.4	0.7	0.7
Illnesses of siblings	1.3	1.9	3.0	-1.5	-1.4	-1.3	-1.4	1.3	-1.3	1.4	1.2	-1.7	1.1	1.1	1.3
Neuroticism score	0.1	0.2	0.5	-0.5	-0.6	-0.1	-0.2	0.2	-0.7	0.6	0.4	-0.3	0.7	-0.0	-0.0
Weight	0.4	2.1	6.6	2.5	1.5	0.3	0.8	-0.9	2.6	-1.4	-1.2	1.9	-0.4	-0.9	-0.4
Impedance of arm (right)	0.8	3.9	22.9	-2.5	-3.2	0.2	-0.5	0.9	-4.8	1.0	1.2	-1.2	0.8	0.9	0.6
Arm fat percentage (right)	0.1	0.4	3.0	0.2	-0.9	-1.7	0.2	-0.3	-0.3	-0.5	-0.4	-0.6	-0.1	-0.6	-0.2
Trunk fat-free mass	1.3	7.5	22.8	4.0	4.4	1.9	1.4	-1.5	4.8	-2.1	-1.7	3.8	-0.5	-1.1	-0.8
Hip circumference	0.1	0.5	1.7	1.3	-0.3	-0.6	0.3	-0.4	1.2	-0.6	-0.6	0.6	0.4	-0.6	-0.0
Time employed in main current job	1.0	1.2	3.2	-1.6	0.2	-0.1	-1.2	1.1	-1.1	0.9	0.9	-1.8	0.5	1.3	0.9
Alcohol intake versus 10 years previously	0.1	0.2	0.8	-0.2	0.7	-0.9	0.1	-0.1	-0.5	0.1	-0.0	-0.6	0.2	-0.2	-0.2
Father’s age at death	2.0	2.7	4.4	-2.0	-0.2	0.5	-1.9	1.9	-1.2	2.1	1.9	-1.6	1.3	1.9	1.8
Worrier / anxious feelings	0.5	1.0	2.0	0.7	1.2	-0.2	1.4	-1.4	0.3	-0.6	-0.9	0.9	-0.5	-1.4	-1.4
Frequency of tiredness / lethargy in last 2 weeks	3.6	5.8	10.4	3.0	1.0	0.7	2.8	-2.7	2.2	-2.5	-2.4	2.6	-1.7	-3.2	-2.9
Falls in the last year	1.5	2.0	4.1	1.7	0.5	-0.3	1.6	-1.6	1.6	-1.3	-1.3	1.5	-1.0	-2.0	-1.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.6	-0.0	0.6	-0.8	0.3	-0.2	-0.6	-0.1	0.0	-0.3	0.2	-0.1	-0.5
Number of live births	0.3	0.4	1.0	0.3	-0.7	-1.0	0.3	-0.5	1.0	-0.4	-0.5	0.2	-0.8	-0.8	-0.4
Forced expiratory volume in 1-second (FEV1)	3.1	10.5	18.3	4.3	3.5	0.2	3.5	-3.2	3.5	-3.3	-2.9	4.3	-2.0	-3.0	-3.1
Pulse rate	0.8	1.3	2.6	-0.6	1.6	-0.7	-1.0	1.1	0.2	1.3	1.3	-0.6	1.4	1.6	1.3
Happiness	0.5	0.7	1.5	1.2	0.9	-0.4	0.7	-0.6	0.9	-0.8	-0.5	1.1	0.6	-0.9	-0.6
Noisy workplace	0.5	0.6	3.9	-0.7	-2.0	-0.7	-0.6	0.4	-0.9	0.3	0.5	-0.7	0.5	0.2	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	-0.4	0.5	-0.0	-0.5	0.5	0.6	0.8	0.6	-0.4	0.4	0.4	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	1.3	1.0	0.1	0.8	-0.8	1.2	-0.8	-0.9	0.9	-0.4	-0.9	-0.8
Mouth/teeth dental problems: Dentures	0.6	1.0	3.1	1.2	0.1	0.9	0.7	-0.9	1.8	-0.4	-0.9	1.1	-1.4	-0.8	-0.5
Asthma	0.1	0.2	0.7	0.3	-0.5	0.8	-0.1	-0.1	0.5	0.2	0.1	0.6	-0.1	-0.5	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.9	0.2	-0.9	-0.2	0.0	-0.1	0.3	0.4	0.1	0.1	0.1	-0.0	0.1
Medication: Cholesterol lowering	0.5	0.7	6.2	-0.6	-0.8	0.0	0.4	-0.3	-2.5	-0.7	-0.5	-0.7	-0.2	-0.3	-0.3
Depression (self-reported)	0.6	0.7	1.4	0.7	-0.3	-0.5	1.0	-1.0	0.8	-1.0	-1.0	0.8	-0.8	-1.2	-0.8
Medication: Lansoprazole	0.4	0.4	1.0	-0.8	-0.9	-0.9	-0.5	0.5	-0.7	0.5	0.3	-1.0	-0.1	0.5	0.6
Prospective memory result	0.8	1.0	1.9	0.9	0.9	-0.1	1.2	-1.2	0.0	-1.2	-1.3	0.4	-1.4	-1.0	-1.2
Lung cancer (father)	0.1	0.1	0.5	0.2	-0.1	-0.1	0.4	-0.4	-0.3	-0.7	-0.4	0.2	-0.1	-0.6	-0.5
Illnesses of mother	1.7	2.1	4.9	-1.0	-0.0	0.2	-1.8	1.8	0.7	2.1	1.8	-0.3	1.3	2.2	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	3.7	11.8	18.8	4.3	3.4	0.5	3.8	-3.6	3.3	-3.7	-3.3	4.3	-2.4	-3.4	-3.4
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	-0.5	-0.6	0.3	-1.0	1.1	-0.7	0.7	1.0	-0.3	0.9	1.1	1.1
Impedance of arm (left)	1.1	4.9	23.7	-2.9	-3.6	-0.2	-0.9	1.3	-4.9	1.5	1.7	-1.7	1.2	1.1	0.8
Arm fat mass (right)	0.1	0.5	1.4	1.2	0.2	-1.2	0.3	-0.4	1.1	-0.8	-0.7	0.3	-0.1	-0.6	-0.2
Trunk predicted mass	1.3	7.3	22.4	3.9	4.4	1.9	1.3	-1.4	4.7	-2.0	-1.6	3.8	-0.4	-1.1	-0.8
Standing height	0.5	4.8	19.1	2.9	2.4	4.0	0.7	-0.5	2.2	-1.3	-0.5	4.4	0.6	-0.1	0.3
Length of working week for main job	0.4	0.4	1.8	-0.9	-0.7	-0.4	-0.1	0.0	-1.4	0.1	-0.1	-1.0	-0.6	0.2	0.0
Exposure to tobacco smoke at home	3.2	3.6	5.1	1.9	1.4	0.4	2.0	-2.1	1.8	-2.3	-2.1	1.8	-2.2	-2.0	-1.9
Breastfed as a baby	2.0	2.4	4.6	-1.1	-0.4	0.7	-2.0	2.1	0.4	1.8	1.9	-0.6	1.9	1.9	2.1
Tense / ‘highly strung’	0.5	0.8	3.2	0.7	1.8	-0.4	0.9	-0.9	0.4	-0.8	-0.8	0.8	-0.6	-0.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.0	5.6	2.3	1.4	0.7	2.2	-2.2	2.0	-2.1	-2.0	2.4	-1.6	-2.4	-2.0
Hair/balding pattern: Pattern 4	0.9	2.1	10.1	1.3	1.9	3.2	1.3	-1.1	0.5	-0.9	-0.7	1.5	-0.7	-0.6	-1.4
Birth weight of first child	1.7	3.1	4.8	-2.2	-0.4	-1.1	-1.8	1.9	-2.0	1.6	1.8	-2.1	2.1	1.8	1.6
Peak expiratory flow (PEF)	1.9	4.4	8.0	2.8	2.6	-0.4	2.1	-2.0	2.8	-2.2	-2.0	2.2	-1.3	-1.8	-1.7
Pulse wave reflection index	1.3	1.6	3.0	1.6	0.3	0.5	1.1	-1.2	0.9	-1.7	-1.5	1.6	-1.7	-1.2	-0.9
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.3	-1.2	0.6	-0.3	-1.4	1.4	-0.6	1.3	1.2	-1.1	1.1	1.5	1.4
Loud music exposure frequency	0.7	0.8	3.4	0.5	-1.8	-1.9	0.4	-0.4	-0.0	-0.6	-0.4	0.2	0.1	-1.0	-0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.2	-0.5	-0.9	-0.4	0.1	-0.3	-0.6	-0.2	-0.6	-1.1	-1.1	-0.3	-0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.3	0.8	1.1	0.9	0.6	-0.4	0.5	-0.6	-0.2	0.7	0.0	-0.2	-0.5
Blood clot in the leg (DVT)	1.2	1.5	3.3	1.3	0.9	1.5	1.0	-1.1	1.4	-1.5	-1.4	0.6	-1.8	-0.9	-0.8
Medication: Paracetamol	0.2	0.3	1.3	-0.2	-0.7	-0.2	-0.5	0.5	0.3	0.5	0.7	0.2	1.1	0.5	0.7
Headache pain in last month	0.6	1.0	9.2	0.5	0.2	3.0	-0.1	0.1	0.5	0.3	0.4	1.1	0.6	0.3	0.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.9	-0.4	0.0	-0.5	-1.4	1.2	2.0	1.6	1.2	-0.4	0.8	1.2	1.4
Glaucoma (self-reported)	0.5	0.5	2.4	-0.0	-0.2	-0.1	0.8	-0.7	-1.6	-0.8	-0.5	-0.2	-0.3	-0.7	-1.2
Gout (self-reported)	0.5	0.6	1.3	0.8	0.7	0.3	0.8	-0.8	1.0	-0.8	-0.8	0.7	-0.6	-0.9	-1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	4.0	1.0	0.8	0.9	0.1	-0.1	2.0	-0.2	0.1	1.4	0.4	-0.2	0.1
Medication: Amlodipine	1.2	1.7	4.1	1.4	1.1	-0.3	1.8	-1.5	-0.4	-1.4	-1.1	1.4	-0.7	-1.5	-2.0
Medication: Ventolin 100micrograms inhaler	1.1	1.3	3.7	-0.1	0.4	1.9	-1.0	1.2	0.9	1.4	1.4	0.7	1.5	1.2	1.1
Birth weight	0.6	1.2	3.6	-1.9	-0.6	-0.9	-0.9	0.8	-1.1	1.2	0.8	-1.9	0.4	0.9	0.6
Chronic bronchitis/emphysema (mother)	1.0	1.2	5.0	-1.4	-1.5	-1.3	-0.3	0.4	-2.2	0.2	0.2	-1.7	0.4	0.1	-0.1
High blood pressure (siblings)	2.8	4.0	5.1	2.2	1.8	1.3	2.2	-2.2	1.8	-2.3	-2.1	2.0	-1.9	-1.9	-2.1
Forced vital capacity (FVC), Best measure	3.0	11.1	17.9	4.2	3.3	1.3	3.7	-3.5	3.0	-3.6	-3.2	4.2	-2.4	-3.2	-3.3
Body fat percentage	0.1	0.4	2.6	0.3	-1.6	-1.1	-0.0	-0.1	-0.2	-0.4	-0.3	-0.3	-0.0	-0.4	0.1
Leg fat percentage (right)	0.1	0.3	1.2	0.7	-0.9	-1.1	0.1	-0.3	0.4	-0.5	-0.5	-0.1	-0.1	-0.4	0.1
Arm fat-free mass (right)	1.2	6.3	23.2	3.8	3.6	1.2	1.2	-1.4	4.8	-2.0	-1.7	3.3	-0.7	-1.3	-0.8
Exposure to tobacco smoke outside home	1.5	1.9	3.4	1.3	-0.5	-1.7	1.5	-1.6	0.8	-1.4	-1.7	0.6	-1.5	-1.8	-1.5
Comparative body size at age 10	0.7	2.0	4.1	1.3	2.0	-0.0	1.6	-1.5	1.2	-1.6	-1.5	0.8	-1.1	-1.3	-1.9
Number of full brothers	1.4	1.8	7.4	1.6	2.7	-0.1	1.2	-1.1	1.2	-1.3	-0.9	1.5	-0.3	-0.9	-1.3
Worry too long after embarrassment	1.2	1.9	3.0	-1.7	-1.1	0.5	-1.6	1.5	-1.2	1.5	1.4	-1.4	1.4	1.4	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.7	1.0	-0.1	-1.1	1.5	-1.4	0.4	-1.3	-1.4	0.3	-1.0	-1.6	-1.4
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	-0.6	-0.8	0.2	-0.8	0.6	-0.2	0.4	0.6	-0.9	0.7	0.4	0.8
Number of children fathered	1.4	1.5	6.2	-1.3	-0.0	2.5	-1.0	1.1	-1.1	1.0	1.2	-0.7	0.9	1.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	2.7	-1.6	-0.9	0.5	-1.3	1.4	-1.6	1.1	1.1	-1.6	1.1	1.5	1.3
Age at first live birth	0.4	0.6	2.1	-1.1	-1.2	0.0	-0.3	0.4	-1.5	0.2	0.1	-1.4	-0.2	0.6	0.4
Pulse wave peak to peak time	0.5	0.6	1.0	0.5	0.7	-0.1	0.9	-1.0	0.7	-0.6	-0.9	0.5	-0.7	-1.0	-0.9
Health satisfaction	1.5	2.0	3.6	1.7	-0.3	-1.5	1.4	-1.5	1.4	-1.6	-1.6	0.9	-1.1	-1.9	-1.2
Shortness of breath walking on level ground	1.0	1.2	6.6	-0.8	-1.0	-2.6	0.3	-0.5	-1.3	-0.1	-0.5	-1.5	-0.3	-0.8	-0.8
Qualifications: College or University degree	0.4	1.4	4.4	-1.7	-1.7	-0.9	-1.0	1.0	-1.2	0.8	0.6	-2.1	-0.0	1.0	0.8
Eye problems/disorders: None of the above	0.4	0.5	1.8	-0.8	0.7	-1.0	-0.4	0.4	-0.0	0.8	0.3	-1.3	-0.3	0.6	0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.6	0.9	0.2	-0.6	0.4	-0.5	1.2	-0.4	-0.6	0.5	-0.5	-0.8	-0.2
Emphysema/chronic bronchitis	0.3	0.3	0.9	-0.3	-0.1	-0.3	0.6	-0.6	-0.6	-0.5	-0.5	-0.5	-0.5	-0.7	-1.0
Medication for pain relief, constipation, heartburn	0.6	0.9	3.1	-1.4	-0.3	-0.5	-1.1	1.1	-1.0	0.5	0.5	-1.8	-0.0	1.0	0.9
Neck or shoulder pain in last month	0.3	0.4	0.8	0.6	0.0	-0.9	0.7	-0.7	0.4	-0.7	-0.8	0.4	-0.8	-0.7	-0.5
Medication: Blood pressure	1.8	3.1	6.7	1.3	1.0	1.1	2.4	-2.1	-1.2	-2.2	-1.8	1.3	-1.1	-2.0	-2.6
Angina (self-reported)	0.4	0.5	2.2	0.1	-1.5	-0.7	0.6	-0.6	-0.7	-0.4	-0.5	-0.3	0.0	-1.0	-0.8
Migraine (self-reported)	0.3	0.4	2.4	0.3	0.9	0.0	-0.5	0.3	1.5	0.6	0.4	0.2	0.2	0.3	0.4
Medication: Ibuprofen	0.1	0.2	0.8	0.3	-0.9	-0.7	0.3	-0.4	0.1	0.3	-0.2	0.0	-0.2	-0.3	-0.2
Medication: Allopurinol	0.1	0.1	0.4	-0.4	-0.3	-0.1	-0.2	0.2	-0.5	-0.2	0.1	-0.4	0.6	0.0	-0.3
Medication: Omeprazole	2.3	2.8	4.6	2.1	1.6	-0.6	1.9	-1.8	1.6	-1.6	-1.5	2.1	-0.8	-1.9	-1.8
Medication: Seretide 50 evohaler	1.3	1.4	2.8	1.5	1.4	1.5	1.0	-1.0	1.3	-1.0	-0.7	1.7	-0.7	-1.0	-1.1
Mean time to correctly identify matches	0.2	0.4	2.1	-0.1	0.5	0.3	-0.4	0.5	-0.6	0.3	0.8	0.6	1.5	0.4	0.5
Heart disease (mother)	0.4	0.5	1.0	0.3	-0.6	-0.1	0.8	-0.8	-0.4	-0.8	-0.9	0.1	-0.8	-1.0	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.0	-1.4	0.1	0.5	-1.0	1.0	-0.6	1.3	0.9	-1.4	0.8	1.3	0.8
Whole body fat mass	0.2	0.8	2.5	1.6	-0.1	-0.5	0.6	-0.7	1.2	-1.1	-0.9	0.9	-0.3	-0.9	-0.3
Leg fat mass (right)	0.2	0.9	2.9	1.7	0.4	-0.7	0.6	-0.8	1.5	-1.2	-1.1	0.8	-0.4	-0.8	-0.3
Arm predicted mass (right)	1.2	6.1	23.4	3.7	3.4	1.1	1.2	-1.4	4.8	-1.9	-1.6	3.3	-0.6	-1.2	-0.7
Pulse rate, automated reading	0.5	1.6	3.8	-1.3	1.0	-1.5	-1.1	1.1	-1.2	1.2	1.0	-1.9	0.5	1.8	1.2
Alcohol intake frequency.	0.1	0.2	0.7	0.1	0.8	-0.8	0.4	-0.4	-0.5	-0.1	-0.1	-0.2	0.3	-0.3	-0.4
Comparative height size at age 10	0.4	2.2	7.6	2.4	-0.3	1.1	1.1	-1.1	1.5	-1.6	-1.3	2.8	-0.4	-1.4	-0.6
Number of full sisters	1.8	2.2	4.1	-1.2	0.9	0.8	-1.9	2.0	0.2	1.4	1.7	-0.7	1.3	2.0	2.0
Suffer from ‘nerves’	0.9	1.5	7.5	0.9	2.7	1.8	0.3	-0.3	1.6	0.2	0.1	1.8	0.4	-0.2	-0.2
Overall health rating	0.6	1.3	3.8	1.4	-1.2	-1.9	0.9	-1.0	1.1	-0.6	-0.7	0.9	0.2	-1.8	-0.9
Chest pain or discomfort	0.3	0.4	1.1	0.2	1.0	0.3	0.8	-0.8	-0.3	-0.6	-0.6	-0.1	-0.4	-0.7	-0.9
Had major operations	5.6	6.6	11.2	2.0	2.4	1.0	3.3	-3.2	-0.1	-2.9	-3.1	1.4	-2.9	-2.7	-3.3
Age at last live birth	0.3	0.5	5.3	-0.4	-2.3	-0.1	-0.1	0.1	-0.2	0.2	-0.0	-0.4	-0.3	-0.2	0.2
Family relationship satisfaction	0.1	0.2	0.4	-0.3	0.4	-0.6	-0.3	0.3	-0.5	0.3	0.3	-0.6	0.5	0.2	0.3
Leg pain on walking	0.9	1.1	3.4	-0.8	-1.0	-1.8	-1.1	1.0	-0.1	1.2	0.9	-0.9	1.0	0.6	1.0
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	3.2	1.6	1.6	1.5	1.8	-1.8	0.7	-1.3	-1.4	1.6	-1.5	-1.6	-1.8
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.0	-0.6	-0.4	-0.3	0.1	0.4	-0.2	-0.1	-0.5	-0.0	-0.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	-0.2	0.2	0.4	-0.4	0.4	0.5	0.0	0.1	-0.2	0.0	0.7	0.6
Medication: Aspirin	0.7	0.9	1.5	0.6	0.5	1.0	1.2	-1.2	-0.8	-1.2	-1.1	0.5	-0.9	-1.1	-1.2
Supplements: Vitamin C	0.6	0.7	3.7	-0.3	-1.4	-1.9	-0.8	0.5	0.2	0.0	0.0	-0.8	-0.0	-0.2	1.0
Knee pain experienced in last month	5.9	9.2	13.7	3.7	0.7	-0.0	3.2	-3.3	3.1	-3.4	-3.2	3.4	-2.8	-3.7	-3.2
Hypertension (Self-reported)	3.9	10.8	18.3	3.1	3.1	0.3	4.0	-3.9	0.6	-4.3	-3.9	2.6	-3.0	-3.8	-4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	4.3	1.7	-0.8	-0.4	1.1	-1.2	1.8	-1.2	-1.1	2.1	-0.7	-1.5	-0.9
Illnesses of father: Heart disease	0.8	1.0	1.9	1.1	0.9	0.5	1.1	-1.0	0.6	-1.4	-1.2	1.1	-1.1	-0.9	-1.0
Illnesses of siblings: Diabetes	0.7	0.8	1.6	0.6	0.9	1.1	0.9	-0.9	0.0	-1.3	-0.9	0.8	-0.6	-0.8	-1.3
Smoking status: Previous	2.8	4.2	6.3	2.0	2.5	1.3	2.3	-2.2	1.0	-2.5	-2.3	1.7	-2.3	-1.9	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	6.2	2.0	0.4	0.4	1.4	-1.2	1.1	-1.4	-1.2	2.5	-0.6	-1.4	-1.0
Whole body fat-free mass	1.4	7.7	21.3	4.1	4.1	1.5	1.8	-1.9	4.6	-2.4	-2.0	3.7	-0.9	-1.6	-1.3
Leg fat-free mass (right)	1.2	6.5	13.8	3.6	3.5	0.8	2.1	-2.1	3.7	-2.6	-2.2	3.1	-1.2	-1.9	-1.7
Arm fat percentage (left)	0.1	0.5	3.6	-0.0	-1.1	-1.9	-0.1	0.0	-0.4	-0.1	-0.0	-0.9	0.4	-0.3	-0.0
Average weekly red wine intake	1.9	2.8	4.2	-2.1	-1.5	-1.1	-1.8	1.8	-1.7	1.4	1.6	-2.1	1.5	1.7	1.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.6	-1.0	-0.7	-0.5	-1.3	1.2	-1.0	1.1	1.0	-1.1	0.9	1.2	1.6
Mood swings	0.2	0.3	1.8	0.1	-1.4	-0.7	0.3	-0.4	-0.6	0.0	-0.2	-0.2	0.1	-0.5	-0.5
Loneliness, isolation	0.1	0.1	0.4	0.4	0.3	-0.2	0.3	-0.3	0.0	0.0	0.0	0.5	0.6	-0.6	-0.5
Long-standing illness, disability or infirmity	0.8	1.3	3.6	0.6	-1.9	-1.8	1.0	-1.0	-0.7	-0.9	-0.9	-0.2	-0.3	-1.6	-1.1
Ever had bowel cancer screening	1.9	2.3	4.0	-1.9	0.8	1.4	-1.2	1.3	-2.0	1.9	1.7	-1.2	1.6	1.6	0.8
Diabetes diagnosed by doctor	0.7	1.2	2.8	-0.1	-1.1	-0.5	0.9	-1.0	-1.7	-1.0	-1.2	-1.1	-1.4	-1.0	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.2	5.8	1.3	-0.7	-0.7	1.1	-1.5	1.6	-1.8	-2.1	0.6	-2.4	-1.8	-0.8
Friendships satisfaction	0.6	0.8	1.9	-0.6	-0.6	1.4	-1.0	0.9	-0.5	0.7	0.9	-0.4	1.1	0.8	1.1
Qualifications: nursing, teaching	1.2	1.9	6.1	1.4	0.9	2.5	1.1	-1.0	1.6	-1.4	-1.2	1.7	-0.9	-1.0	-1.0
Commuting to job workplace: Walk	0.3	0.4	1.5	-0.2	-1.2	0.1	-0.8	0.6	0.6	0.7	0.6	-0.2	0.4	0.3	0.6
Eye problems/disorders: Cataract	2.5	2.9	4.5	1.8	0.3	1.1	2.0	-2.0	1.1	-2.1	-1.9	1.9	-1.7	-1.9	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	0.1	0.6	-0.3	-0.4	0.5	0.7	1.0	0.7	0.1	0.6	0.2	0.2
Medication for cholesterol	0.5	0.8	4.6	-0.6	-2.1	0.7	-0.9	0.8	-0.2	1.0	0.8	-0.0	0.4	0.7	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	0.8	-0.9	-0.3	0.7	-0.9	0.5	-0.6	-1.0	0.5	-1.0	-0.9	-0.7
Back pain experienced in last month	0.8	1.1	3.3	-0.9	-1.8	-1.2	-1.2	1.0	-0.1	1.0	0.9	-0.9	1.2	0.4	1.2
Mineral and other dietary supplements	0.5	0.7	5.2	-0.3	-0.7	-2.3	0.3	-0.2	-1.2	-0.1	-0.1	-0.8	0.1	0.1	-0.2
Breast cancer (self-reported)	0.3	0.3	1.3	0.3	-0.4	0.2	0.4	-0.6	0.4	-0.4	-0.7	0.1	-1.1	-0.6	-0.7
Asthma (self-reported)	0.1	0.3	1.1	0.5	-0.5	1.1	0.0	-0.1	0.7	0.1	0.1	0.8	-0.2	-0.6	-0.2
Osteoporosis (self-reported)	0.8	1.0	1.8	-1.3	-0.7	0.5	-1.2	1.2	-0.9	0.9	0.8	-0.7	0.5	1.3	1.3
Osteoarthritis (self-reported)	0.3	0.4	0.8	-0.3	-0.5	0.5	-0.9	0.7	0.9	0.4	0.5	-0.6	0.8	0.6	0.7
Medication: Aspirin	0.4	0.5	0.9	0.3	0.2	0.5	0.9	-0.9	-0.8	-0.8	-0.7	0.1	-0.5	-0.9	-1.0
Medication: Gliclazide	2.6	2.9	5.5	1.7	2.0	0.6	1.8	-1.9	0.9	-1.7	-1.9	1.5	-2.3	-1.7	-1.7
Illnesses of father: None of the above (group 1)	0.1	0.2	1.2	-0.3	-0.4	1.1	-0.1	0.1	-0.6	0.1	-0.0	-0.1	-0.3	0.2	0.2
Smoking status: Current	0.1	0.1	0.6	-0.1	0.5	-0.8	0.2	-0.2	-0.2	-0.4	-0.2	-0.5	-0.2	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.8	8.6	2.5	1.8	0.1	2.9	-2.9	1.0	-2.9	-2.7	2.3	-2.2	-2.8	-2.9
Whole body water mass	1.3	7.5	20.6	4.0	4.0	1.4	1.8	-1.9	4.5	-2.5	-2.0	3.7	-0.9	-1.6	-1.3
Leg predicted mass (right)	1.2	6.6	13.7	3.7	3.5	0.8	2.1	-2.2	3.7	-2.6	-2.3	3.1	-1.2	-2.0	-1.8
Arm fat mass (left)	0.1	0.4	1.2	1.1	0.2	-1.0	0.2	-0.3	1.1	-0.6	-0.5	0.3	0.1	-0.5	-0.1
Number of self-reported non-cancer illnesses	0.4	0.8	1.5	1.0	0.4	0.4	1.1	-1.0	0.3	-1.0	-0.8	1.2	-0.2	-1.2	-0.8
Average weekly champagne plus white wine intake	0.2	0.3	0.4	0.6	0.7	-0.3	0.5	-0.5	0.5	-0.5	-0.5	0.6	-0.6	-0.4	-0.4
Miserableness	1.1	1.9	3.6	1.0	-0.7	-1.7	1.6	-1.7	0.0	-1.3	-1.6	0.6	-1.1	-1.9	-1.8
Guilty feelings	0.6	0.9	4.2	-0.0	-2.1	-0.4	-0.7	0.7	1.2	1.1	1.0	0.5	1.3	0.1	0.8
Wears glasses or contact lenses	1.5	1.7	2.8	-1.7	-0.7	0.0	-1.6	1.5	-0.9	1.4	1.5	-1.4	1.3	1.5	1.2
Ever taken oral contraceptive pill	0.2	0.2	0.9	0.3	0.8	0.9	-0.0	-0.0	0.7	0.0	-0.3	0.4	-0.6	0.2	0.2
Hearing aid user	0.1	0.1	0.5	-0.1	0.7	-0.5	0.2	-0.2	0.0	0.3	-0.1	-0.6	-0.3	-0.0	-0.4
Mother’s age at death	1.9	2.4	4.8	-1.3	-2.2	-0.8	-1.6	1.6	-1.6	1.5	1.3	-1.6	1.6	1.5	1.7
Financial situation satisfaction	0.2	0.3	0.8	-0.4	-0.6	-0.7	-0.6	0.6	-0.6	0.3	0.4	-0.4	0.3	0.5	0.9
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	0.0	0.6	0.5	0.2	-0.0	0.0	0.4	0.1	0.0	0.3	0.2	-0.5
Commuting to job workplace: Public transport	0.3	0.4	1.6	-0.4	0.9	-1.0	0.2	-0.1	-1.2	0.3	0.1	-0.7	-0.1	0.1	-0.2
Eye problems/disorders: Glaucoma	0.3	0.3	3.1	-0.3	0.2	-0.0	0.2	0.0	-1.8	-0.1	0.1	-0.5	0.4	0.2	-0.5
Medication: Blood pressure	6.6	12.5	18.6	3.6	3.5	-0.7	4.1	-4.1	1.7	-4.3	-4.1	2.8	-3.6	-3.9	-3.9
Pain type(s) experienced in last month: Hip pain	2.0	2.5	6.0	-1.1	-2.1	-1.5	-1.6	1.5	-0.1	2.0	1.8	-0.7	2.5	0.8	1.6
Supplements: Fish oil (including cod liver oil)	0.1	0.2	1.1	0.1	0.3	1.1	-0.3	0.2	0.5	0.2	0.2	0.5	0.1	-0.1	0.0
High cholesterol (Self-reported)	0.2	0.4	1.6	-0.7	1.2	0.1	-0.1	0.2	-1.3	0.3	0.3	-0.6	0.6	0.3	0.2
Medication: Bendroflumethiazide	1.7	2.6	5.7	0.7	-0.8	-1.5	1.9	-2.0	-0.9	-1.8	-1.9	0.4	-1.5	-2.4	-2.0
Medication: Paracetamol	0.5	0.8	3.3	-0.3	-0.5	-0.8	-0.7	0.8	0.2	0.9	1.2	0.1	1.8	0.7	0.9
Medication: Lisinopril	1.5	2.0	3.4	1.2	0.8	-0.7	1.8	-1.8	-1.0	-1.8	-1.8	0.7	-1.2	-1.5	-1.8
Medication: Atorvastatin	0.5	0.6	1.6	0.1	0.8	0.3	0.8	-0.8	-1.3	-1.1	-1.0	-0.6	-1.0	-0.2	-0.7
Illnesses of father: High blood pressure	1.3	1.6	2.8	1.4	0.1	-0.7	1.3	-1.4	1.4	-1.5	-1.5	0.9	-1.3	-1.7	-1.3
Alcohol drinker status: Never	0.6	0.7	3.0	0.8	1.7	0.7	0.6	-0.5	1.4	0.1	0.1	0.8	0.6	-0.5	-0.7
Ever smoked	3.5	6.2	8.7	2.4	2.3	0.5	2.9	-2.9	1.6	-2.8	-2.8	2.2	-2.8	-2.6	-2.9
Basal metabolic rate	1.2	6.5	18.0	3.9	3.5	1.1	1.7	-1.8	4.2	-2.4	-2.0	3.4	-0.9	-1.6	-1.2
Leg fat percentage (left)	0.1	0.3	1.1	0.8	-0.7	-1.0	0.0	-0.2	0.8	-0.4	-0.4	0.0	-0.0	-0.4	0.1
Arm fat-free mass (left)	1.3	6.4	21.6	3.9	3.5	1.3	1.4	-1.6	4.7	-2.1	-1.9	3.4	-0.9	-1.4	-0.9
Number of operations (self-reported)	0.2	0.3	0.7	0.2	0.4	0.9	0.6	-0.7	-0.3	-0.5	-0.6	0.3	-0.3	-0.7	-0.7
Average weekly beer plus cider intake	0.3	0.4	1.2	0.9	-0.1	-1.1	0.4	-0.4	1.0	-0.5	-0.5	0.7	-0.1	-0.7	-0.1
Irritability	0.3	0.5	1.1	0.1	-0.2	0.1	1.0	-0.8	-1.0	-0.5	-0.7	0.0	-0.7	-0.7	-1.1
Risk taking	0.5	0.8	3.0	0.4	-0.5	-0.1	0.7	-0.9	0.4	-1.1	-1.1	0.0	-1.7	-1.1	-1.0
Ever had prostate specific antigen (PSA) test	0.9	1.0	4.9	1.1	1.4	2.2	0.5	-0.2	0.8	-0.9	-0.1	1.5	0.5	0.1	-0.2
Fractured/broken bones in last 5 years	0.9	1.1	3.1	-0.9	-0.6	-0.1	-1.3	1.3	0.1	1.3	1.1	-0.6	0.9	1.4	1.8
Age started oral contraceptive pill	0.4	0.5	1.1	-1.0	-0.4	-0.2	-1.0	0.8	0.2	1.0	0.5	-0.6	0.3	0.8	1.1
Diastolic blood pressure, automated reading	1.6	5.0	16.3	2.2	4.0	-1.5	2.1	-2.2	1.4	-2.5	-2.4	1.1	-2.1	-1.8	-1.9
Ever depressed for a whole week	0.5	0.6	1.3	-0.2	-0.9	-0.6	0.7	-0.6	-1.2	-0.6	-0.9	-0.5	-1.1	-0.6	-0.8
Unable to work because of sickness or disability	1.5	1.9	3.7	1.9	1.4	-0.0	1.4	-1.2	1.9	-1.5	-1.1	1.7	-0.2	-1.5	-1.4
Commuting to job workplace: Cycle	0.4	0.5	1.9	0.4	1.4	1.3	-0.0	0.0	1.1	0.5	-0.0	0.8	-0.6	0.4	-0.0
Myopia	0.2	0.3	0.8	-0.9	0.1	0.4	-0.4	0.5	-0.8	0.8	0.6	-0.4	0.3	0.5	0.2
Vascular/heart problems diagnosed by doctor	4.2	11.3	20.6	-3.2	-2.8	0.1	-4.1	4.0	-0.5	4.5	4.1	-2.4	3.3	3.9	4.0
Cholesterol lowering medication	0.4	0.5	3.2	-0.8	1.8	-0.1	-0.2	0.2	-0.8	0.3	0.2	-1.1	0.3	0.5	0.1
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.3	1.7	0.6	-1.1	1.6	-1.6	1.2	-1.5	-1.5	1.7	-1.0	-1.8	-1.6
Pain experienced in last month	0.5	0.8	2.5	-1.4	0.3	-0.3	-0.7	0.8	-1.6	0.6	0.6	-1.4	0.2	1.2	0.5
Supplements: Calcium	0.7	0.7	4.1	0.2	1.3	2.0	-0.4	0.4	0.8	0.3	0.4	0.9	0.6	0.4	0.5
Basal cell carcinoma (self-reported)	1.6	1.9	3.3	1.6	1.2	1.1	1.3	-1.3	1.8	-1.1	-1.3	1.4	-1.4	-1.6	-1.3
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.7	0.4	-0.1	-1.9	1.2	-1.2	-0.9	-1.5	-1.4	-0.7	-0.7	-1.2	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.8	1.1	0.8	1.7	0.8	-1.0	1.3	-1.3	-1.3	0.4	-1.7	-0.7	-0.7
Heart disease (siblings)	0.4	0.5	3.5	0.6	1.9	0.9	0.1	0.0	0.7	-0.1	0.1	0.8	0.0	0.3	0.1
Alcohol drinker status: Previous	3.3	3.8	6.4	2.0	0.9	0.3	2.4	-2.4	0.9	-2.3	-2.2	1.6	-1.8	-2.4	-2.5
Pack years of smoking	0.1	0.1	0.6	0.3	0.8	-0.3	0.3	-0.2	-0.0	-0.3	0.1	0.2	0.3	-0.1	-0.4
Impedance of whole body	0.7	3.6	16.9	-2.2	-4.1	0.2	-0.9	1.1	-3.7	1.3	1.3	-0.9	0.9	0.7	0.9
Leg fat mass (left)	0.3	1.1	3.2	1.8	0.6	-0.7	0.6	-0.8	1.8	-1.2	-1.1	0.9	-0.4	-0.9	-0.3
Arm predicted mass (left)	1.4	7.3	25.2	4.1	3.6	1.4	1.4	-1.7	5.0	-2.2	-2.0	3.6	-1.0	-1.4	-0.9