[Hub]/) : Traits : Systolic Blood Pressure : ← →

chr2:23,453,834-26,068,509

Best TWAS P=2.45e-20 · Best GWAS P=2.31e-16 conditioned to 0.627

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	-8.21	5.6	2.5e-08	-0.89	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	-0.74	5.2	1.6e-07	-0.49	0.55	0.14	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	-8.01	-7.7	1.3e-14	0.87	0.05	0.94	FALSE
4	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	-3.17	-5.2	2.0e-07	0.83	0.05	0.87	FALSE
5	GTEx	Adipose Visceral Omentum	NCOA1	0.11	0.02	enet	17	0.02	2.1e-02	-6.17	-7.2	5.4e-13	0.34	0.08	0.55	FALSE
6	GTEx	Adrenal Gland	PTRHD1	0.32	0.28	lasso	3	0.26	8.3e-10	5.53	-5.5	2.8e-08	0.41	0.98	0.00	FALSE
7	GTEx	Artery Aorta	NCOA1	0.15	0.00	enet	15	0.01	1.4e-01	-7.05	-6.2	5.9e-10	0.37	0.06	0.26	FALSE
8	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	-6.94	-6.6	3.9e-11	0.70	0.42	0.58	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	-8.01	9.2	2.5e-20	-0.84	0.03	0.96	TRUE
10	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	-8.01	8.8	1.2e-18	-0.93	0.03	0.92	FALSE
11	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	-8.11	-7.7	1.7e-14	0.45	0.04	0.59	FALSE
12	GTEx	Muscle Skeletal	UBXN2A	0.10	0.04	lasso	7	0.03	5.5e-04	5.02	5.5	4.6e-08	0.06	0.48	0.51	FALSE
13	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	-6.94	8.1	5.5e-16	-0.92	0.03	0.97	FALSE
14	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	-6.94	6.8	1.3e-11	-0.82	0.06	0.92	FALSE
15	GTEx	Prostate	FAM228B	0.16	0.02	enet	31	0.07	9.6e-03	4.06	-5.7	1.1e-08	-0.02	0.15	0.12	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	UBXN2A	0.12	0.06	enet	33	0.12	6.8e-07	4.16	6.3	2.4e-10	-0.03	0.66	0.26	TRUE
17	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	-7.77	-7.8	7.6e-15	0.80	0.14	0.86	FALSE
18	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	-7.57	-7.3	2.5e-13	0.87	0.19	0.81	FALSE
19	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	-7.77	-7.0	2.1e-12	0.87	0.15	0.85	FALSE
20	METSIM	Adipose	EFR3B	0.04	0.00	bslmm	357	0.00	9.7e-02	4.41	5.4	8.0e-08	-0.37	0.04	0.31	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	-7.57	7.2	8.5e-13	-0.90	0.27	0.73	FALSE
22	YFS	Blood	CENPO	0.09	0.06	lasso	6	0.07	6.7e-21	-6.16	5.8	5.0e-09	-0.24	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	-5.70	6.1	1.3e-09	-0.51	0.59	0.36	FALSE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	ADCY3	0.36	0.14	enet	7	0.13	8.9e-05	-7.83	8.0	1.4e-15	-0.38	0.02	0.42	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADCY3	0.08	0.03	enet	16	0.03	1.5e-04	-5.59	6.7	2.4e-11	-0.18	0.03	0.08	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	6.24	6.2	4.3e-10	-0.64	0.58	0.02	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	-7.77	8.4	3.4e-17	-0.89	0.03	0.95	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	-3.69	7.3	2.2e-13	-0.55	0.43	0.50	FALSE
29	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EFR3B	0.26	0.01	lasso	4	0.05	3.8e-03	-8.11	-7.6	2.5e-14	0.35	0.00	0.92	FALSE