Best TWAS P=2.05e-13 · Best GWAS P=1.11e-11 conditioned to 0.853
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C2orf47 | 0.05 | 0.02 | blup | 361 | 0.02 | 4.3e-03 | 6.8 | -7.3 | 2.1e-13 | -0.85 | 0.01 | 0.99 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | SF3B1 | 0.06 | 0.07 | enet | 10 | 0.07 | 2.5e-09 | 6.6 | 6.6 | 4.2e-11 | 0.05 | 0.02 | 0.98 | FALSE |
3 | GTEx | Brain Caudate basal ganglia | TYW5 | 0.23 | 0.11 | lasso | 3 | 0.11 | 5.4e-04 | 4.4 | -5.5 | 3.7e-08 | -0.52 | 0.06 | 0.37 | FALSE |
4 | GTEx | Breast Mammary Tissue | SF3B1 | 0.06 | 0.06 | lasso | 4 | 0.03 | 6.6e-03 | 6.6 | 6.7 | 1.5e-11 | 0.06 | 0.04 | 0.92 | TRUE |
5 | GTEx | Breast Mammary Tissue (Female) | SF3B1 | 0.05 | -0.01 | lasso | 3 | -0.01 | 8.1e-01 | 6.7 | 6.7 | 1.7e-11 | 0.07 | 0.03 | 0.43 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | MARS2 | 0.15 | 0.14 | lasso | 4 | 0.07 | 2.6e-03 | -5.1 | -5.1 | 2.8e-07 | -0.09 | 0.13 | 0.30 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | C2orf69 | 0.07 | 0.10 | enet | 17 | 0.10 | 2.7e-08 | 6.7 | 5.7 | 1.5e-08 | 0.92 | 0.01 | 0.99 | FALSE |
8 | GTEx | Esophagus Mucosa | SF3B1 | 0.04 | 0.02 | lasso | 4 | 0.01 | 5.7e-02 | 6.4 | 6.5 | 8.0e-11 | 0.06 | 0.05 | 0.85 | FALSE |
9 | GTEx | Esophagus Muscularis | SF3B1 | 0.06 | 0.02 | lasso | 4 | 0.03 | 1.0e-02 | 5.6 | 5.3 | 1.1e-07 | 0.03 | 0.07 | 0.67 | FALSE |
10 | GTEx | Lung | SF3B1 | 0.06 | 0.04 | enet | 23 | 0.02 | 2.2e-02 | 6.4 | 5.8 | 9.1e-09 | 0.07 | 0.03 | 0.94 | FALSE |
11 | GTEx | Nerve Tibial | SF3B1 | 0.06 | 0.09 | lasso | 8 | 0.08 | 3.3e-06 | 6.7 | 6.2 | 4.2e-10 | 0.06 | 0.08 | 0.92 | FALSE |
12 | GTEx | Pituitary | HSPD1 | 0.10 | 0.03 | enet | 12 | 0.06 | 1.3e-02 | 4.8 | 6.7 | 2.1e-11 | 0.09 | 0.08 | 0.39 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | SF3B1 | 0.08 | 0.00 | enet | 19 | 0.01 | 1.6e-01 | 6.5 | 5.7 | 1.2e-08 | 0.07 | 0.04 | 0.89 | FALSE |
14 | GTEx | Spleen | KCTD18 | 0.26 | 0.03 | lasso | 4 | 0.04 | 3.8e-02 | 4.8 | 5.7 | 1.0e-08 | 0.85 | 0.11 | 0.35 | FALSE |
15 | GTEx | Spleen | RFTN2 | 0.11 | 0.03 | enet | 26 | 0.05 | 2.4e-02 | 4.8 | 5.2 | 1.5e-07 | 0.08 | 0.11 | 0.23 | FALSE |
16 | GTEx | Spleen | MARS2 | 0.12 | 0.04 | lasso | 5 | 0.00 | 3.4e-01 | 4.7 | -5.2 | 1.8e-07 | -0.07 | 0.08 | 0.23 | FALSE |
17 | GTEx | Stomach | SF3B1 | 0.11 | 0.00 | enet | 19 | 0.00 | 4.0e-01 | 5.6 | 5.1 | 3.0e-07 | 0.06 | 0.06 | 0.44 | FALSE |
18 | GTEx | Testis | ANKRD44 | 0.33 | 0.35 | enet | 15 | 0.36 | 6.2e-17 | 5.7 | 5.4 | 7.9e-08 | 0.07 | 0.74 | 0.26 | FALSE |
19 | GTEx | Testis | SF3B1 | 0.10 | 0.07 | enet | 17 | 0.08 | 2.6e-04 | 6.6 | 6.3 | 3.5e-10 | 0.07 | 0.03 | 0.96 | FALSE |
20 | GTEx | Testis | C2orf69 | 0.14 | 0.09 | enet | 17 | 0.10 | 2.7e-05 | 6.8 | 6.8 | 9.7e-12 | 0.93 | 0.02 | 0.98 | FALSE |
21 | GTEx | Thyroid | SF3B1 | 0.04 | 0.02 | enet | 14 | 0.02 | 2.0e-02 | 5.3 | 5.7 | 1.2e-08 | 0.08 | 0.09 | 0.83 | FALSE |
22 | GTEx | Thyroid | PLCL1 | 0.04 | 0.01 | lasso | 4 | 0.00 | 2.6e-01 | 4.4 | 5.5 | 3.4e-08 | 0.08 | 0.16 | 0.60 | FALSE |
23 | GTEx | Whole Blood | C2orf47 | 0.04 | 0.05 | lasso | 2 | 0.03 | 3.6e-04 | 6.6 | 6.6 | 4.4e-11 | 1.00 | 0.02 | 0.97 | FALSE |
24 | METSIM | Adipose | C2orf69 | 0.04 | 0.03 | blup | 376 | 0.04 | 1.3e-06 | 4.2 | 5.7 | 1.0e-08 | 0.84 | 0.04 | 0.96 | FALSE |
25 | NTR | Blood | ANKRD44 | 0.03 | 0.00 | bslmm | 417 | 0.02 | 2.7e-06 | 6.0 | -6.5 | 7.7e-11 | -0.07 | 0.07 | 0.88 | FALSE |
26 | ROSMAP | Brain Pre-frontal Cortex | SF3B1 | 0.02 | 0.01 | blup | 336 | 0.01 | 6.2e-03 | 5.4 | 6.0 | 2.0e-09 | 0.07 | 0.06 | 0.91 | FALSE |
27 | YFS | Blood | ANKRD44 | 0.02 | 0.00 | blup | 416 | 0.01 | 6.3e-04 | 2.4 | -6.6 | 3.4e-11 | -0.04 | 0.10 | 0.63 | FALSE |
28 | The Cancer Genome Atlas | Colon Adenocarcinoma | C2orf60 | 0.08 | 0.06 | enet | 11 | 0.06 | 1.4e-04 | 6.6 | -6.3 | 3.6e-10 | -0.91 | 0.01 | 0.94 | FALSE |
29 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C2orf69 | 0.02 | 0.00 | blup | 35 | 0.01 | 2.6e-02 | 3.3 | 5.7 | 1.6e-08 | 0.85 | 0.02 | 0.76 | FALSE |
30 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RFTN2 | 0.05 | 0.01 | blup | 61 | 0.02 | 3.1e-02 | 6.5 | 6.2 | 6.0e-10 | 0.07 | 0.02 | 0.71 | FALSE |
31 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2orf47 | 0.15 | 0.05 | blup | 39 | 0.05 | 7.6e-03 | 6.7 | -5.8 | 6.8e-09 | -0.94 | 0.00 | 0.97 | FALSE |
32 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2orf60 | 0.15 | 0.05 | enet | 12 | 0.08 | 8.2e-04 | 6.6 | -5.6 | 2.0e-08 | -0.86 | 0.01 | 0.98 | FALSE |