Best TWAS P=8.16e-09 · Best GWAS P=1.22e-07 conditioned to 0.562
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | KAT8 | 0.06 | 0.07 | lasso | 1 | 0.07 | 3.9e-09 | -5.1 | 5.1 | 2.6e-07 | -0.92 | 0.03 | 0.97 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | ZNF646 | 0.04 | 0.06 | lasso | 7 | 0.04 | 4.5e-06 | -5.3 | 5.4 | 8.7e-08 | -0.97 | 0.02 | 0.98 | FALSE |
3 | GTEx | Adrenal Gland | KAT8 | 0.11 | 0.06 | enet | 11 | 0.07 | 1.8e-03 | -5.1 | 5.6 | 2.1e-08 | -0.92 | 0.04 | 0.87 | FALSE |
4 | GTEx | Artery Aorta | KAT8 | 0.23 | 0.20 | lasso | 4 | 0.20 | 2.7e-11 | -5.1 | 5.3 | 1.2e-07 | -0.90 | 0.04 | 0.96 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | KAT8 | 0.12 | 0.23 | lasso | 3 | 0.18 | 2.9e-05 | -5.1 | 5.1 | 2.8e-07 | -0.95 | 0.03 | 0.86 | FALSE |
6 | GTEx | Brain Cortex | KAT8 | 0.14 | 0.14 | lasso | 3 | 0.10 | 8.9e-04 | -5.5 | 5.7 | 1.2e-08 | -0.91 | 0.02 | 0.89 | FALSE |
7 | GTEx | Brain Frontal Cortex BA9 | KAT8 | 0.16 | 0.20 | lasso | 1 | 0.17 | 2.6e-05 | -5.2 | 5.2 | 2.4e-07 | -0.94 | 0.03 | 0.88 | FALSE |
8 | GTEx | Breast Mammary Tissue | KAT8 | 0.23 | 0.14 | lasso | 10 | 0.17 | 4.4e-09 | -5.1 | 5.2 | 2.6e-07 | -0.82 | 0.04 | 0.95 | FALSE |
9 | GTEx | Esophagus Mucosa | BCKDK | 0.05 | 0.05 | enet | 6 | 0.06 | 8.7e-05 | -5.3 | -5.8 | 8.2e-09 | 0.87 | 0.03 | 0.92 | TRUE |
10 | GTEx | Liver | PRSS53 | 0.22 | 0.08 | lasso | 5 | 0.11 | 5.5e-04 | -5.4 | 5.5 | 4.3e-08 | -0.92 | 0.02 | 0.90 | FALSE |
11 | GTEx | Liver | VKORC1 | 0.22 | 0.20 | lasso | 5 | 0.22 | 1.1e-06 | -5.3 | 5.4 | 7.0e-08 | -0.97 | 0.03 | 0.97 | FALSE |
12 | GTEx | Liver | PRSS36 | 0.13 | 0.03 | enet | 34 | 0.04 | 2.2e-02 | 4.2 | 5.3 | 1.0e-07 | -0.65 | 0.05 | 0.48 | FALSE |
13 | GTEx | Ovary | KAT8 | 0.16 | 0.09 | lasso | 4 | 0.06 | 1.2e-02 | -5.1 | 5.2 | 1.7e-07 | -0.89 | 0.04 | 0.77 | FALSE |
14 | GTEx | Prostate | KAT8 | 0.19 | 0.09 | lasso | 3 | 0.13 | 3.8e-04 | -5.1 | 5.2 | 1.8e-07 | -0.88 | 0.04 | 0.62 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | KAT8 | 0.30 | 0.20 | enet | 15 | 0.26 | 1.9e-14 | 3.5 | 5.2 | 2.2e-07 | -0.78 | 0.09 | 0.91 | FALSE |
16 | GTEx | Stomach | KAT8 | 0.12 | 0.03 | lasso | 5 | 0.07 | 2.9e-04 | 3.6 | 5.3 | 1.2e-07 | -0.78 | 0.05 | 0.92 | FALSE |
17 | GTEx | Thyroid | KAT8 | 0.21 | 0.12 | lasso | 6 | 0.15 | 2.2e-11 | -5.2 | 5.3 | 1.3e-07 | -0.85 | 0.04 | 0.96 | FALSE |
18 | GTEx | Whole Blood | HSD3B7 | 0.06 | 0.06 | lasso | 4 | 0.06 | 2.6e-06 | -5.0 | -5.2 | 2.4e-07 | 0.97 | 0.04 | 0.96 | FALSE |
19 | GTEx | Whole Blood | ZNF668 | 0.05 | 0.06 | lasso | 3 | 0.06 | 5.9e-06 | -5.2 | -5.2 | 2.0e-07 | 0.89 | 0.04 | 0.96 | FALSE |
20 | ROSMAP | Brain Pre-frontal Cortex | KAT8 | 0.13 | 0.16 | lasso | 5 | 0.16 | 4.2e-20 | -5.1 | 5.3 | 1.1e-07 | -0.91 | 0.03 | 0.96 | FALSE |
21 | YFS | Blood | ZNF668 | 0.10 | 0.12 | bslmm | 232 | 0.12 | 1.5e-36 | -5.3 | -5.2 | 1.6e-07 | 0.97 | 0.03 | 0.97 | FALSE |
22 | The Cancer Genome Atlas | Glioblastoma Multiforme | MYST1 | 0.18 | 0.07 | blup | 35 | 0.11 | 4.2e-04 | -5.3 | 5.4 | 5.2e-08 | -0.93 | 0.02 | 0.90 | FALSE |
23 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZNF668 | 0.03 | 0.01 | lasso | 3 | 0.01 | 2.5e-02 | -5.3 | -5.5 | 3.8e-08 | 0.96 | 0.01 | 0.87 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | VKORC1 | 0.03 | 0.04 | lasso | 3 | 0.04 | 3.2e-05 | -5.3 | 5.3 | 1.2e-07 | -0.99 | 0.02 | 0.98 | FALSE |
25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF668 | 0.02 | 0.02 | blup | 32 | 0.02 | 2.9e-03 | -5.2 | -5.4 | 6.0e-08 | 0.95 | 0.01 | 0.93 | FALSE |
26 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MYST1 | 0.16 | 0.08 | blup | 34 | 0.12 | 1.5e-13 | -5.1 | 5.4 | 5.6e-08 | -0.80 | 0.02 | 0.98 | FALSE |
27 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF668 | 0.02 | 0.01 | enet | 8 | 0.02 | 3.1e-03 | -5.3 | -5.1 | 2.9e-07 | 0.90 | 0.02 | 0.81 | FALSE |
28 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | VKORC1 | 0.10 | 0.03 | enet | 7 | 0.07 | 3.8e-04 | -5.1 | 5.5 | 2.9e-08 | -0.94 | 0.02 | 0.96 | FALSE |
29 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MYST1 | 0.03 | 0.05 | blup | 34 | 0.03 | 2.1e-03 | -5.3 | 5.4 | 5.1e-08 | -0.94 | 0.02 | 0.92 | FALSE |
30 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MYST1 | 0.22 | 0.15 | blup | 36 | 0.21 | 2.1e-09 | -5.2 | 5.6 | 1.6e-08 | -0.85 | 0.02 | 0.98 | FALSE |
31 | The Cancer Genome Atlas | Rectum Adenocarcinoma | MYST1 | 0.13 | 0.05 | blup | 35 | 0.06 | 1.9e-02 | -5.2 | 5.4 | 6.2e-08 | -0.92 | 0.01 | 0.61 | FALSE |
32 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | MYST1 | 0.13 | 0.06 | blup | 34 | 0.12 | 6.8e-05 | -5.1 | 5.4 | 8.4e-08 | -0.91 | 0.02 | 0.94 | FALSE |