TWAS hub - ZNF646

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0200	4.1e-05	0.056	0.034	0.033	0.032	0.044	2.4e-07	4.5e-05	5.5e-05	7.5e-05	4.5e-06
2	ROSMAP	Brain Pre-frontal Cortex	0.0648	0.0302	5.7e-04	0.015	0.009	0.011	0.011	0.005	4.3e-03	2.1e-02	1.3e-02	1.1e-02	5.7e-02
3	YFS	Blood	0.0294	0.0124	1.8e-06	0.013	0.017	0.019	0.018	0.016	2.5e-05	1.9e-06	3.9e-07	1.2e-06	3.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hip circumference	16.0	68.8	114.5	10.7	9.5	1.4
Body mass index (BMI)	15.2	64.8	102.8	10.1	9.6	-0.1
Waist circumference	14.9	54.6	86.7	9.3	8.7	1.4
High blood pressure (siblings)	13.8	20.0	29.7	5.4	5.4	0.7
Arm fat mass (left)	12.8	52.4	88.9	9.4	8.2	1.0
Arm fat mass (right)	12.6	51.7	87.6	9.4	8.2	0.7
Leg fat mass (left)	12.2	47.5	79.7	8.9	7.8	1.3
BMI	12.1	70.1	108.2	10.4	10.1	0.0
Leg fat mass (right)	12.1	46.9	79.9	8.9	7.7	1.5
Illnesses of siblings	11.5	16.2	26.1	-5.1	-4.7	0.1
Arm fat percentage (right)	11.2	44.3	78.7	8.9	7.2	1.4
Alzheimer’s Disease (including proxy)	11.1	16.1	24.3	-4.9	-4.3	-2.3
Arm fat percentage (left)	11.1	44.2	78.0	8.8	7.2	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	11.1	23.5	36.5	-6.0	-5.0	-3.0
Triglycerides	10.9	17.8	28.6	5.4	4.8	1.1
Whole body fat mass	10.7	44.7	78.1	8.8	7.3	1.7
Leg fat percentage (left)	10.6	38.3	66.1	8.1	6.7	1.8
Number of incorrect matches in round	10.5	17.5	31.9	-5.7	-4.4	-0.9
Weight	10.4	51.3	85.4	9.2	8.2	0.9
Overall health rating	10.4	22.3	34.4	5.7	5.9	0.1
Financial difficulties in last 2 years	10.1	13.6	23.0	4.2	4.8	0.4
Leg fat percentage (right)	10.1	36.6	63.6	8.0	6.4	2.3
Body fat percentage	9.9	39.1	70.4	8.4	6.4	2.4
Unable to work because of sickness or disability	9.5	12.3	18.0	4.2	4.2	-1.0
Trunk fat mass	9.0	38.5	68.7	8.3	6.6	1.9
Vascular/heart problems diagnosed by doctor	8.7	23.6	36.3	-6.0	-5.9	-0.4
Cholesterol lowering medication	8.4	12.3	21.3	4.6	3.7	1.4
Tense / ‘highly strung’	8.3	13.7	17.1	-4.1	-2.7	-4.1
Alcohol intake frequency.	8.2	19.0	28.9	5.3	5.4	-0.5
Medication: Bendroflumethiazide	8.2	12.4	19.5	4.4	4.2	0.2
Cardiovascular Disease	8.1	26.6	45.2	6.7	5.7	1.4
Trunk fat percentage	8.1	32.6	59.0	7.7	5.7	2.6
Impedance of arm (left)	8.1	37.3	62.7	-6.1	-7.9	3.5
Impedance of whole body	8.1	41.1	67.1	-6.6	-8.2	3.6
Alzheimer’s Disease (in mother)	8.0	9.3	17.4	-4.2	-3.0	-1.3
Impedance of arm (right)	8.0	37.5	63.5	-6.1	-8.0	3.5
Knee pain experienced in last month	7.5	11.6	18.1	4.2	4.1	0.0
Worry (Nagel 2018)	7.4	15.6	22.9	-4.4	-2.2	-4.8
High blood pressure	7.3	20.3	32.8	5.7	5.3	0.7
Medication for cholesterol	7.2	11.0	18.6	-4.3	-3.2	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	7.1	22.7	35.9	-6.0	-5.0	-2.6
Townsend deprivation index at recruitment	6.8	9.5	14.1	3.8	3.7	0.9
Hypertension (Self-reported)	6.8	18.9	31.1	5.6	5.0	1.0
Arm predicted mass (left)	6.8	34.5	52.3	7.2	7.1	-0.6
Neuroticism (Nagel 2018)	6.7	15.6	27.2	-4.1	-1.7	-5.2
Impedance of leg (right)	6.7	32.6	51.3	-6.0	-7.2	3.3
Diastolic blood pressure, automated reading	6.7	20.7	31.9	5.6	5.4	1.1
Arm fat-free mass (left)	6.6	33.3	50.0	7.1	7.0	-0.8
Nervous feelings	6.2	11.6	16.3	-4.0	-2.5	-3.5
Irritability	6.2	10.4	16.7	-3.7	-0.7	-4.1
Pain experienced in last month	6.1	10.2	17.7	-4.2	-3.0	-2.0
Medication: Co-codamol	6.0	7.0	12.9	2.8	3.6	-0.3
Impedance of leg (left)	6.0	29.1	45.7	-5.9	-6.8	2.7
Neuroticism	5.9	14.2	24.8	-4.1	-1.1	-5.0
Arm predicted mass (right)	5.9	30.2	46.5	6.6	6.8	-0.5
Basal metabolic rate	5.9	32.4	50.1	7.1	6.8	-0.6
Worrier / anxious feelings	5.8	11.0	25.4	-2.6	-0.8	-5.0
Falls in the last year	5.8	7.9	12.9	3.6	3.2	0.6
Arm fat-free mass (right)	5.8	29.6	45.7	6.5	6.8	-0.7
Pulse wave peak to peak time	5.7	6.7	11.1	-3.0	-3.3	0.5
Leg fat-free mass (left)	5.5	28.9	45.3	6.7	6.4	-0.4
Leg predicted mass (left)	5.4	28.7	45.0	6.7	6.4	-0.4
Neuroticism score	5.4	11.2	22.9	-3.2	-0.6	-4.8
Medication: Cholesterol lowering	5.4	8.4	12.7	3.6	3.3	1.1
Leg fat-free mass (right)	5.3	28.1	41.9	6.4	6.5	-1.0
Forced expiratory volume in 1-second (FEV1)	5.2	17.4	24.7	-5.0	-4.1	-3.3
Forced vital capacity (FVC), Best measure	5.2	19.2	27.9	-5.3	-4.9	-2.3
Number of full sisters	5.2	6.3	8.0	2.8	2.8	1.8
Leg predicted mass (right)	5.2	27.8	41.3	6.4	6.4	-0.9
Heart disease (siblings)	5.2	6.4	7.1	2.7	2.6	-2.3
Medication: Blood pressure	5.1	9.7	17.8	4.2	2.9	1.7
Fractured/broken bones in last 5 years	5.0	6.4	10.4	3.2	3.0	0.2
Pulse wave Arterial Stiffness index	4.9	5.7	9.2	2.8	3.0	-0.4
High cholesterol (Self-reported)	4.9	8.8	13.5	3.7	3.0	1.9
Wheeze or whistling in the chest in last year	4.7	8.4	14.7	3.8	2.7	1.8
Comparative body size at age 10	4.6	12.8	21.7	4.7	3.0	2.8
Whole body fat-free mass	4.5	25.7	38.9	6.1	6.2	-1.1
Lung FVC	4.4	22.5	28.0	-5.3	-4.4	-4.5
Systolic blood pressure, automated reading	4.4	12.7	21.8	3.2	4.7	-2.4
Medication for cholesterol, blood pressure or diabetes	4.4	7.2	13.5	-2.8	-3.7	0.2
Whole body water mass	4.4	25.1	37.8	6.0	6.2	-1.0
Illnesses of father: High blood pressure	4.4	5.5	8.6	2.8	2.9	0.1
Forced vital capacity (FVC)	4.3	16.6	22.9	-4.8	-4.3	-2.9
Medication: Atorvastatin	4.3	5.3	8.0	2.7	2.8	0.6
Bipolar Disorder (2011)	4.2	4.0	8.8	0.0	-3.0	1.8
Medication: Simvastatin	4.2	6.1	10.0	3.2	2.6	1.2
Qualifications: A levels/AS levels or equivalent	4.2	9.3	17.1	-2.5	-4.1	2.1
Exposure to tobacco smoke outside home	4.2	5.5	9.4	3.1	2.6	-0.5
Number of full brothers	4.2	5.2	9.8	3.1	2.4	-0.2
Hayfever/allergic rhinitis (self-reported)	4.1	5.4	6.7	-2.6	-2.4	1.9
Medication: Paracetamol	3.9	6.4	12.4	3.5	2.6	0.5
Age at first live birth	3.9	7.0	11.3	-3.1	-3.4	-0.1
Medication: Paracetamol	3.9	6.0	11.3	3.4	2.6	0.3
Depressed Affect (Nagel 2018)	3.8	8.1	19.9	-2.1	-0.4	-4.5
Blood Red Count	3.8	36.7	61.5	-6.2	-3.1	-7.8
Number of treatments/medications taken	3.7	6.7	8.1	2.9	2.2	2.7
Medication: Allopurinol	3.7	4.9	9.5	-3.1	-2.3	0.3
Qualifications: College or University degree	3.6	11.4	17.9	-4.0	-4.2	0.9
Number of self-reported non-cancer illnesses	3.6	6.2	9.0	3.0	2.6	1.7
Pulse wave reflection index	3.5	4.3	5.8	2.2	2.4	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.4	4.6	7.5	1.1	2.3	-2.7
Happiness	3.4	4.1	7.5	-2.7	-1.9	-1.1
Medication: Blood pressure	3.4	5.9	11.0	2.3	3.3	-1.2
Diabetes (mother)	3.3	4.2	6.8	2.6	2.4	-0.5
High blood pressure (mother)	3.3	4.6	8.6	1.9	2.9	-1.2
Trunk fat-free mass	3.3	19.2	29.3	5.1	5.4	-1.4
Trunk predicted mass	3.3	18.7	28.8	5.0	5.4	-1.4
Loneliness, isolation	3.3	4.5	11.0	0.2	1.6	-3.3
Alzheimer’s Disease (in father)	3.2	3.4	5.2	-2.0	-2.3	-1.0
Heel T-Score	3.2	25.5	42.1	-6.5	-5.8	0.3
Hand grip strength (left)	3.2	8.4	13.5	3.7	3.3	0.9
Frequency of tenseness / restlessness in last 2 weeks	3.2	5.0	13.0	-1.4	-0.1	-3.6
Breastfed as a baby	3.2	4.0	10.9	0.9	-0.4	3.3
Chronic bronchitis/emphysema (mother)	3.1	3.6	6.8	1.9	0.7	2.6
Myopia	3.1	4.6	6.1	2.5	1.6	2.2
Body Mass Index (BMI) (2010)	3.0	4.1	7.2	2.7	2.1	0.7
Blood Eosinophil Count	3.0	23.2	34.2	-5.8	-5.0	3.2
Smoking Status	3.0	7.2	14.1	3.8	2.7	0.5
Ever had hysterectomy (womb removed)	3.0	3.4	6.5	2.5	1.9	-0.4
Mouth/teeth dental problems: Loose teeth	3.0	3.6	5.4	2.3	2.3	0.2
Mood swings	3.0	5.4	13.1	-1.8	0.2	-3.6
Financial situation satisfaction	3.0	3.7	7.3	1.1	2.7	-1.7
LDL Cholesterol	2.9	4.6	8.3	2.0	2.9	-1.2
Chronic bronchitis/emphysema (father)	2.9	3.4	4.9	2.2	1.8	1.3
Neck or shoulder pain in last month	2.8	3.9	7.3	2.7	2.1	0.5
Suffer from ‘nerves’	2.8	4.4	5.8	-1.9	-1.9	-2.4
HDL Cholesterol	2.7	4.5	9.9	-3.1	-1.7	-0.8
Type 2 Diabetes (T2D) (2018)	2.7	5.1	10.1	3.2	2.3	0.3
Gout (self-reported)	2.7	3.7	6.0	-2.4	-2.2	0.4
Diabetes diagnosed by doctor	2.7	4.4	7.2	2.7	2.0	1.3
Hearing aid user	2.7	3.1	4.3	2.1	1.9	-1.2
Alcohol drinker status: Previous	2.7	3.1	5.8	2.4	1.8	-0.6
Father’s age at death	2.6	3.5	7.0	-2.6	-1.7	-0.8
Leg pain on walking	2.6	3.2	7.2	0.7	1.4	-2.7
Pain all over the body in last month	2.5	2.7	3.5	1.9	1.5	1.5
Diabetes (self-reported)	2.5	3.8	6.1	2.5	1.9	1.4
Hayfever, allergic rhinitis or eczema	2.4	5.2	6.9	-2.6	-2.2	1.9
Fluid intelligence score	2.4	4.9	7.5	2.7	2.7	0.2
Shortness of breath walking on level ground	2.4	2.9	4.5	2.1	2.0	-0.6
Emphysema/chronic bronchitis	2.4	2.7	3.3	1.8	1.7	1.4
Mouth/teeth dental problems: Mouth ulcers	2.4	3.8	6.0	2.3	2.5	0.4
Number of operations (self-reported)	2.4	3.6	6.0	2.2	2.4	0.1
Breast Cancer	2.3	5.5	9.1	3.0	2.7	0.0
Hearing difficulty/problems: Yes	2.3	3.5	4.8	2.2	1.4	1.9
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.2	8.1	-2.8	-2.7	0.5
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	3.7	1.1	1.9	-1.9
Neuroticism (2016)	2.2	3.1	5.2	-2.3	-0.4	-2.0
Primary Biliary Cirrhosis	2.2	3.1	5.4	2.3	1.9	0.3
Relative age voice broke	2.2	3.4	8.7	1.1	-0.7	3.0
Serious illness, injury or assault to yourself	2.2	2.7	5.5	0.7	2.3	-1.4
Had other major operations	2.2	2.6	5.5	2.3	1.5	0.4
Chest pain or discomfort	2.2	3.2	5.4	2.3	2.1	0.1
Medication: Aspirin	2.2	2.8	4.7	1.9	2.2	0.2
Eye problems/disorders: Glaucoma	2.2	2.6	4.6	-1.7	-2.1	0.7
Illnesses of mother	2.1	2.6	5.1	-1.7	-2.3	0.1
Health satisfaction	2.1	2.8	5.8	2.4	1.2	-1.0
Had major operations	2.1	2.4	4.8	1.6	2.2	0.1
Age at First Birth	2.0	2.8	4.7	-1.9	-2.2	0.2
Sensitivity / hurt feelings	2.0	3.4	5.3	-1.9	-1.0	-2.3
Mouth/teeth dental problems	2.0	3.1	5.0	-2.2	-2.0	-0.2
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	4.9	1.8	2.2	-1.3
Asthma	2.0	4.0	9.7	1.5	0.2	3.1
Loud music exposure frequency	2.0	2.1	3.3	1.8	1.7	-0.6
Headache pain in last month	2.0	3.5	7.3	2.7	1.8	-0.3
Birth weight	2.0	4.3	7.4	2.7	2.3	-0.4
Allergy or Eczema	1.9	5.0	6.7	-2.6	-2.0	2.1
Angina	1.9	2.5	3.6	1.3	1.9	-1.5
Age when periods started (menarche)	1.9	4.6	8.6	-2.1	-2.9	0.8
Past tobacco smoking	1.9	3.5	6.6	-2.6	-1.9	-0.6
Angina (self-reported)	1.9	2.4	3.6	1.4	1.9	-1.4
Osteoporosis (self-reported)	1.9	2.3	3.6	1.9	0.4	1.8
Medication: Lisinopril	1.9	2.5	4.2	1.4	2.0	1.1
Blood White Count	1.8	13.4	24.6	-5.0	-3.9	0.8
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	5.6	-0.9	-0.0	-2.4
Ever highly irritable/argumentative for 2 days	1.8	2.2	3.2	-1.5	-1.8	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	3.1	1.7	1.5	1.1
Long-standing illness, disability or infirmity	1.8	2.8	3.7	1.9	1.7	1.3
Medication: Aspirin	1.8	2.4	4.0	1.7	2.0	-0.5
Illnesses of father: None of the above (group 1)	1.8	2.2	4.6	-1.2	-2.2	-0.7
Ever depressed for a whole week	1.8	2.2	3.0	-1.7	-0.8	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.3	4.5	-1.5	0.2	-2.1
Medication for pain relief, constipation, heartburn	1.7	2.9	4.9	-2.2	-1.6	-1.2
Handedness (chirality/laterality): Left-handed	1.7	2.1	3.2	1.7	1.8	0.4
Relative age of first facial hair	1.6	3.4	6.0	2.5	1.2	1.6
Allergy	1.6	3.7	9.1	1.0	1.0	-3.0
Glaucoma (self-reported)	1.6	1.8	4.1	-1.2	-2.0	0.3
Pulse rate, automated reading	1.6	5.3	11.4	1.7	1.3	3.4
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	2.8	-1.2	-1.7	1.2
Asthma (self-reported)	1.6	3.2	7.8	1.4	0.2	2.8
Depression (Nagel 2018)	1.5	2.2	6.3	-0.1	0.5	-2.5
Hand grip strength (right)	1.5	3.9	7.2	2.7	2.0	0.9
Current tobacco smoking	1.5	2.5	5.0	2.2	1.6	-0.0
Medication: Ramipril	1.5	2.0	4.9	2.2	1.0	0.2
Medication: Lansoprazole	1.5	1.7	2.2	1.3	1.5	-1.1
Worry too long after embarrassment	1.5	2.4	3.8	-1.9	-1.0	-1.6
Smoking status: Previous	1.5	2.3	4.5	2.1	1.5	0.4
Ever smoked	1.5	2.5	5.5	2.3	1.4	0.3
Verbal and Numeric Reasoning (VNR)	1.4	3.3	6.8	1.7	2.6	-0.1
Respiratory disease	1.4	3.2	3.7	1.9	1.5	1.9
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	4.3	-0.9	-0.1	-2.1
Friendships satisfaction	1.4	1.7	2.7	-1.7	-1.5	0.5
Commuting to job workplace: Walk	1.4	1.5	3.1	-1.8	-1.0	0.6
Pain type(s) experienced in last month: Hip pain	1.4	1.8	2.7	1.6	1.7	-0.1
Ovarian Cancer	1.3	1.7	2.6	-1.6	-1.5	0.6
Taking other prescription medications	1.3	2.0	5.0	1.0	-0.1	2.2
Illnesses of siblings: Diabetes	1.3	1.6	3.6	1.9	1.1	0.2
Pack years of smoking	1.3	1.9	3.0	1.7	1.3	1.0
Waist Hip Ratio (WHR)	1.2	5.5	8.6	-2.9	-2.6	1.1
Lung FEV1/FVC ratio	1.2	6.1	12.8	-3.6	-1.5	-1.8
Diabetes (father)	1.2	1.5	2.9	-1.7	-1.1	0.7
Fed-up feelings	1.2	2.2	5.8	-0.9	-0.2	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.5	-0.8	0.4	-2.1
Qualifications: nursing, teaching	1.2	1.8	4.2	-2.0	-1.0	0.5
Back pain experienced in last month	1.2	1.8	2.6	1.5	0.8	1.6
Average weekly champagne plus white wine intake	1.2	1.7	2.5	1.5	1.6	-0.5
Miserableness	1.2	2.1	5.4	-0.9	-0.2	-2.3
Guilty feelings	1.2	1.8	4.8	-0.5	0.5	-2.2
Wears glasses or contact lenses	1.2	1.4	2.9	1.7	0.9	0.6
Major Depression (MDD)	1.1	1.3	2.7	-1.6	-0.6	-0.9
Medication: Metformin	1.1	1.6	1.9	1.4	1.1	1.3
Qualifications: CSEs or equivalent	1.1	1.4	2.5	1.6	1.3	0.1
Alcohol intake versus 10 years previously	1.1	1.6	2.7	1.0	1.1	1.6
Birth weight of first child	1.1	2.0	2.3	1.5	1.4	1.4
Ulcerative Colitis	1.0	1.5	2.6	0.4	1.4	-1.6
Pack years adult smoking proportion	1.0	1.6	2.5	1.6	1.3	0.7
Medication: Atenolol	1.0	1.3	1.9	1.0	1.0	-1.4
Had menopause	1.0	1.3	2.3	1.5	0.9	0.9
Time employed in main current job	1.0	1.1	1.5	0.7	-1.2	1.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.7	-0.4	-1.0	1.9
Age at last live birth	1.0	1.5	2.8	-1.2	-1.7	-0.5
Breast cancer (self-reported)	1.0	1.2	1.9	-0.7	-1.4	1.1
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.1	-1.4	-0.6	-1.2
Average weekly beer plus cider intake	1.0	1.4	2.3	-1.5	-1.0	-0.9
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.6	-0.4	-1.6	0.6
Systolic Blood Pressure	0.9	4.6	7.6	1.9	2.8	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.1	-1.7	-1.8	0.2
Noisy workplace	0.9	1.1	1.5	-0.4	1.2	-1.2
Exposure to tobacco smoke at home	0.9	1.0	1.5	1.2	1.2	-0.0
Eye problems/disorders: None of the above	0.9	1.0	1.8	0.6	1.3	-0.9
Migraine (self-reported)	0.9	1.2	2.1	1.0	1.4	-0.6
Family relationship satisfaction	0.9	1.1	2.0	-0.3	-1.1	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.8	-1.7	-0.7	-0.2
Medication: Gliclazide	0.9	1.1	2.7	0.7	-0.2	1.6
Smoking status: Current	0.9	1.4	3.0	1.7	1.0	0.1
Reaction Time	0.8	1.5	3.3	1.8	1.1	0.4
Vitamin and mineral supplements	0.8	1.1	3.0	-1.7	-0.2	-0.6
Qualifications: None of the above	0.8	1.6	2.3	1.5	1.4	-0.7
Peak expiratory flow (PEF)	0.8	1.8	3.1	-1.2	-0.9	-1.8
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.4	0.9	1.0	1.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.9	0.3	0.9	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.3	0.7	1.1	-1.0
Mean Putamen Volume	0.7	0.8	1.9	-0.2	-1.4	0.7
Schizophrenia (2014)	0.7	1.5	1.8	-1.2	-1.3	1.1
Hypothyroidism (self reported)	0.7	1.6	3.5	-1.0	-1.9	-0.5
Number of live births	0.7	1.0	1.8	0.7	1.4	-0.8
Eye problems/disorders: Cataract	0.7	0.8	1.9	0.8	-0.0	1.4
Commuting to job workplace: Cycle	0.7	0.9	1.5	-0.6	-0.8	1.2
Irritable Bowel Disease (IBD)	0.6	1.4	3.0	-0.4	1.1	-1.7
Chronotype (morning person)	0.6	1.5	3.7	0.4	0.7	-1.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.3	-0.0	-0.2	-1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.0	1.0	0.7	0.6
Hearing difficulty/problems with background noise	0.6	1.0	2.8	0.4	-0.2	1.7
Pulse rate	0.6	1.1	3.0	-0.3	-0.4	1.7
Prospective memory result	0.6	0.7	1.7	-1.3	-0.5	-0.5
Average weekly red wine intake	0.6	0.8	2.4	-0.3	-1.6	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	0.8	-0.8	-0.9	-0.8
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	1.3	0.6	-0.3
Risk taking	0.6	0.9	1.3	1.1	0.8	0.9
Basal cell carcinoma (self-reported)	0.6	0.7	1.2	-0.8	-1.1	0.4
Bipolar Disorder (2018)	0.5	0.8	2.1	-0.0	0.5	1.4
Crohns Disease (2017)	0.5	1.0	2.7	-0.4	0.5	-1.6
Fasting Glucose	0.5	0.6	1.1	0.6	1.0	-0.7
Blood Platelet Count	0.5	5.4	10.6	0.9	3.2	-2.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.6	1.3	0.7	0.3
Supplements: Glucosamine	0.5	0.6	1.3	-1.2	-0.7	0.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.0	-1.0	-0.9	0.3
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	0.7	0.4	1.2
Mouth/teeth dental problems: Dentures	0.5	0.9	1.3	1.1	1.1	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	0.9	-0.5	0.8
Length of working week for main job	0.5	0.6	1.4	-0.5	-1.2	-0.4
Mean time to correctly identify matches	0.5	0.9	1.8	1.3	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	1.2	-1.1	-0.9	-0.9
Bipolar Disorder or Schizophrenia	0.4	1.0	2.4	-0.7	-0.3	1.5
Average weekly spirits intake	0.4	0.4	1.2	0.4	0.1	1.1
Medication for hormone replacement therapy	0.4	0.4	1.0	0.1	-0.4	1.0
Average weekly fortified wine intake	0.4	0.4	0.8	-0.4	-0.6	0.9
Sitting height	0.4	2.5	5.7	-1.3	-0.0	-2.4
Alcohol usually taken with meals	0.4	0.6	1.1	-0.1	-0.9	1.0
Depression (self-reported)	0.4	0.5	1.4	-0.1	-0.3	-1.2
Standing height	0.4	4.0	6.0	-1.6	-2.4	1.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.6	-0.7	-1.3	0.3
Medication: Seretide 50 evohaler	0.4	0.5	1.1	-0.4	-0.3	1.1
Mineral and other dietary supplements	0.4	0.5	0.9	1.0	0.7	-0.4
Ever taken oral contraceptive pill	0.4	0.4	0.8	0.9	0.4	0.4
Commuting to job workplace: Public transport	0.4	0.5	1.1	1.1	-0.1	0.5
Schizophrenia (2018)	0.3	0.7	0.8	-0.9	-0.8	0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	-0.6	-0.9	-0.4
Height	0.3	5.1	10.4	0.3	-2.2	3.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.5	0.6	0.7	-0.4
Stomach or abdominal pain in last month	0.3	0.4	0.9	-0.3	0.5	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	-0.4	-0.9	-0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.9	0.3	0.0	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.5	-0.7	-0.6	-0.5
Medication: Ibuprofen	0.3	0.4	0.5	0.7	-0.5	0.7
Illnesses of father: Heart disease	0.3	0.5	1.2	0.4	1.1	-0.2
Supplements: Calcium	0.3	0.3	0.6	0.8	0.2	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	0.7	0.5	1.0
Ulcerative Colitis (UC)	0.2	0.5	0.8	-0.4	0.9	-0.7
HbA1C	0.2	0.2	0.5	-0.4	-0.1	0.7
Lupus	0.2	0.3	0.6	0.2	-0.6	-0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.3	0.5	0.5	0.5
Multivitamins +/- minerals	0.2	0.2	0.7	0.9	0.0	0.1
Medication: Levothyroxine sodium	0.2	0.4	0.6	-0.5	-0.8	0.5
Heart attack	0.2	0.2	0.3	0.4	0.5	0.4
Lung cancer (father)	0.2	0.2	0.5	-0.3	0.1	-0.7
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	0.4	0.9	-0.7
Blood clot in the leg (DVT)	0.2	0.3	0.5	0.6	0.7	0.0
Number of children fathered	0.2	0.2	0.3	0.3	0.5	-0.6
Medication: Omeprazole	0.2	0.2	0.3	-0.5	0.3	0.4
Comparative height size at age 10	0.2	1.3	2.9	-0.5	-0.8	1.7
Supplements: Vitamin C	0.2	0.2	0.5	0.1	-0.2	0.7
Ever had bowel cancer screening	0.2	0.2	0.5	0.3	0.2	-0.7
Osteoarthritis (self-reported)	0.2	0.3	0.8	-0.3	0.9	0.1
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	-0.4	-0.8	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.4	0.2	0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.5	0.8	-0.0
Prostate Cancer	0.1	0.2	0.5	-0.7	-0.1	0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.3	0.5	0.2
Crohns Disease (2012)	0.1	0.1	0.3	-0.6	0.1	-0.3
Rheumatoid Arthritis	0.1	0.1	0.2	0.2	0.4	-0.4
Hair Pigment	0.1	2.6	4.6	-1.8	-2.1	0.4
Tanning	0.1	1.5	2.9	-1.7	-1.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	0.1	0.4	-0.3
Medication: Amlodipine	0.1	0.1	0.4	0.1	0.6	-0.2
Heart disease (mother)	0.1	0.2	0.2	0.4	0.5	-0.3
Alcohol drinker status: Never	0.1	0.1	0.2	0.4	0.3	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.4	0.6	0.3
Supplements: Zinc	0.0	0.0	0.1	-0.3	0.2	-0.2
Severe depression (siblings)	0.0	0.0	0.1	-0.3	0.1	-0.2
Maternal smoking around birth	0.0	0.0	0.1	0.2	-0.2	0.0
Mother’s age at death	0.0	0.0	0.1	-0.3	0.1	-0.0
Age started oral contraceptive pill	0.0	0.1	0.2	0.0	0.4	0.1

Hub : Genes

ZNF646

Models

Trait associations