Hub : Genes

VKORC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0290 0.0200 1.5e-02 0.041 0.007 0.024 0.014 0.034 7.7e-06 3.7e-02 5.7e-04 6.4e-03 4.9e-05
2 GTEx Liver 0.2200 0.0750 2.0e-05 0.200 NA 0.161 NA 0.216 3.0e-06 NA 2.9e-05 NA 1.1e-06
3 GTEx Small Intestine Terminal Ileum 0.3040 0.1140 5.2e-03 0.055 NA 0.118 NA 0.088 2.4e-02 NA 1.4e-03 NA 5.4e-03
4 ROSMAP Brain Pre-frontal Cortex 0.0453 0.0208 2.2e-06 0.017 0.044 0.046 0.041 0.044 2.5e-03 2.4e-06 1.2e-06 4.4e-06 2.1e-06
5 YFS Blood 0.0825 0.0258 0.0e+00 0.040 0.070 0.075 0.071 0.072 4.6e-13 7.3e-22 2.7e-23 3.1e-22 1.5e-22
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0329 0.0204 3.5e-05 0.043 0.038 0.032 NA 0.039 1.2e-05 3.4e-05 1.3e-04 NA 3.2e-05
7 TCGA Brain Lower Grade Glioma 0.0512 0.0399 5.8e-04 0.021 0.033 0.030 NA 0.032 1.7e-03 1.0e-04 2.0e-04 NA 1.4e-04
8 TCGA Liver Hepatocellular Carcinoma 0.1040 0.0600 1.4e-04 0.030 0.067 0.069 NA 0.045 1.4e-02 4.6e-04 3.8e-04 NA 3.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.4 0.6 1.7 -0.1 -0.3 -0.5 -1.3 -1.3 -0.2 0.9 -0.7
Bipolar Disorder or Schizophrenia 0.5 1.3 3.1 0.3 -1.0 -1.4 -0.3 -0.5 -1.0 1.8 -1.7
Depressed Affect (Nagel 2018) 0.7 1.4 4.2 0.2 -1.7 -0.5 1.9 0.1 -2.0 -0.3 -0.7
Depression (Nagel 2018) 0.5 0.7 2.5 -1.1 0.0 0.0 -1.0 -0.8 -0.1 -1.6 0.3
Intelligence (Savage-Jansen 2018) 0.1 0.4 2.3 0.0 0.3 0.3 -1.5 -0.2 0.5 -0.2 -0.4
Neuroticism (Nagel 2018) 3.8 8.9 17.1 2.5 -3.9 -2.7 3.7 2.0 -4.1 1.2 -2.6
Schizophrenia (2018) 0.6 1.3 2.6 0.5 -1.0 -1.5 0.6 0.6 -1.1 1.6 -1.6
Schizophrenia vs Biploar Disorder 0.4 0.5 1.2 -1.1 -0.5 -0.5 0.8 0.9 -0.6 0.1 -0.6
Worry (Nagel 2018) 5.8 12.3 21.6 3.3 -4.4 -4.1 3.1 2.6 -4.6 1.6 -3.5
Alzheimer’s Disease (in mother) 10.7 12.6 17.9 3.4 -4.2 -3.7 2.2 3.7 -4.2 3.1 -3.5
Alzheimer’s Disease (in father) 3.0 3.3 5.6 1.6 -2.3 -0.6 1.6 2.1 -2.4 1.4 -1.8
Alzheimer’s Disease (including proxy) 13.1 19.0 29.2 4.3 -5.4 -3.9 3.4 4.7 -5.2 3.3 -4.2
Crohns Disease (2017) 0.2 0.5 2.7 0.1 -0.2 -0.5 1.6 -0.5 0.0 -0.9 0.6
Irritable Bowel Disease (IBD) 0.3 0.8 4.2 0.0 0.1 -0.2 2.1 -0.6 0.2 -0.8 0.9
Ulcerative Colitis (UC) 0.2 0.4 2.4 0.0 0.1 0.3 1.5 -0.3 0.2 -0.2 0.6
Major Depression (MDD) 0.8 0.9 2.6 1.6 -1.1 -0.3 0.7 -0.5 -1.2 0.7 -0.9
Reaction Time 0.3 0.5 1.1 -1.0 0.9 0.1 0.1 -0.9 0.9 -0.4 0.3
Verbal and Numeric Reasoning (VNR) 1.1 2.5 5.3 -1.2 1.7 1.1 -2.3 -1.3 1.7 -2.0 1.0
Breast Cancer 3.0 7.2 13.0 -3.6 2.7 1.8 -3.1 -2.4 2.7 -2.5 2.4
Ovarian Cancer 0.9 1.2 2.5 0.8 -1.2 -0.0 0.7 0.4 -1.4 1.6 -1.4
Prostate Cancer 0.4 0.6 2.9 -0.4 -0.4 -0.6 1.7 1.1 -0.1 0.3 0.1
Age at First Birth 2.1 3.1 5.3 2.1 -2.0 -1.3 0.8 1.1 -2.1 2.3 -1.8
Bipolar Disorder (2011) 4.4 4.3 13.0 0.7 0.0 0.0 0.6 1.4 -2.8 3.2 -3.6
Body Mass Index (BMI) (2010) 3.1 4.2 7.3 -1.3 2.5 1.3 -1.8 -1.6 2.6 -2.0 2.7
Coronary Artery Disease (CAD) 0.1 0.1 0.2 0.1 0.4 -0.2 0.4 0.0 -0.2 -0.3 -0.2
Crohns Disease (2012) 0.3 0.5 2.3 1.0 -0.4 -0.4 1.5 -0.4 -0.2 -0.3 -0.0
Mean Putamen Volume 0.6 0.7 1.6 0.3 -1.1 -0.1 0.5 0.1 -1.1 1.3 -0.8
Fasting Glucose 0.7 0.8 1.8 0.1 0.7 1.1 -0.8 -1.4 0.9 -0.8 1.0
HbA1C 0.7 0.8 4.6 -2.1 -0.3 -0.7 -0.7 0.3 -0.5 0.3 -0.2
HDL Cholesterol 3.4 5.6 9.6 2.1 -2.9 -1.4 2.0 1.7 -2.9 2.4 -3.1
LDL Cholesterol 2.6 4.2 8.2 -1.4 2.4 1.0 -1.6 -1.0 2.5 -2.5 2.9
Lupus 1.4 2.2 12.0 -0.5 -0.6 0.3 -3.5 1.1 -0.8 0.8 -1.4
Neuroticism (2016) 1.8 2.6 4.7 2.0 -2.2 -1.1 2.0 0.9 -1.9 0.6 -1.5
Primary Biliary Cirrhosis 2.9 4.1 6.8 -2.6 1.9 0.9 -2.6 -2.6 1.9 -1.2 1.7
Rheumatoid Arthritis 0.9 1.2 5.2 -2.3 0.2 2.0 0.2 -0.5 0.2 -0.4 0.3
Schizophrenia (2014) 0.9 2.0 4.5 0.9 -1.5 -1.3 0.1 0.5 -1.5 2.1 -2.1
Triglycerides 14.5 23.7 30.8 -5.1 5.4 4.4 -3.9 -4.9 5.3 -4.1 5.5
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.8 0.5 -0.6 -0.1 0.1 -0.4 -0.7 0.9 -0.9
Ulcerative Colitis 0.5 0.7 1.9 -0.5 0.7 0.8 0.5 -0.7 0.6 -1.4 1.0
Blood Eosinophil Count 2.7 21.0 37.8 4.6 -5.8 -4.4 1.0 2.7 -5.3 4.5 -6.2
Blood Platelet Count 0.1 1.4 3.5 -0.5 0.5 -1.2 -1.8 -1.4 0.5 -1.9 0.1
Blood Red Count 2.7 25.7 67.6 5.5 -6.1 -1.9 8.2 4.4 -5.8 1.3 -3.5
Blood White Count 2.7 20.3 42.8 6.5 -4.8 -5.9 3.1 1.2 -4.1 3.6 -4.5
Heel T-Score 4.2 33.4 47.9 6.9 -6.5 -5.4 4.3 5.1 -6.3 5.5 -5.8
BMI 14.8 85.7 110.2 -10.1 10.5 8.7 -7.1 -8.1 10.4 -9.0 9.6
Height 0.1 1.4 5.3 2.3 0.7 0.7 -0.5 -0.5 1.1 1.7 0.6
Waist Hip Ratio (WHR) 1.5 6.7 13.8 3.3 -2.5 -1.3 3.7 1.9 -2.3 2.7 -2.3
Systolic Blood Pressure 0.8 3.9 6.2 -2.5 1.9 2.5 0.3 -1.5 2.2 -1.8 2.2
Smoking Status 4.5 10.8 15.2 -2.1 3.5 2.6 -3.8 -3.0 3.9 -3.7 3.3
Allergy or Eczema 1.9 4.9 10.4 1.2 -2.7 -2.2 0.5 0.5 -2.4 3.2 -2.9
Cardiovascular Disease 10.4 34.4 50.0 -7.1 6.7 5.2 -5.3 -4.4 6.8 -5.2 5.7
Hypothyroidism (self reported) 0.6 1.3 2.5 1.2 -1.4 -0.0 1.6 1.5 -1.1 0.7 -0.8
Respiratory disease 1.5 3.3 6.3 -2.5 2.3 2.2 -0.7 -1.6 2.2 -0.7 1.1
Type 2 Diabetes (T2D) (2018) 4.5 8.4 11.9 -3.0 3.2 2.9 -1.5 -2.7 3.4 -2.8 3.2
Lung FEV1/FVC ratio 1.5 7.8 14.6 3.8 -3.6 -2.8 0.8 1.9 -3.2 1.6 -3.2
Lung FVC 4.8 24.6 37.0 6.0 -5.6 -3.9 6.1 4.8 -5.6 3.0 -3.7
Neuroticism 3.2 7.7 14.9 2.4 -3.7 -2.6 3.4 1.0 -3.9 1.4 -2.4
Chronotype (morning person) 0.4 0.9 3.4 -0.9 0.6 1.9 0.7 0.5 0.4 -0.9 0.9
Hair Pigment 0.1 3.0 7.0 1.3 -1.9 -2.6 1.9 0.9 -1.9 1.6 -1.2
Tanning 0.2 2.3 3.8 0.6 -1.7 -1.7 -0.9 1.8 -1.7 1.3 -2.0
Hand grip strength (left) 5.0 13.2 22.9 -4.0 4.0 4.8 -3.2 -3.1 3.7 -2.4 3.4
Number of treatments/medications taken 3.1 5.5 11.4 -3.4 2.7 1.6 -2.9 -1.9 2.7 -1.2 1.6
Average weekly spirits intake 1.3 1.6 6.5 -2.6 0.6 1.1 -1.0 -1.7 0.5 -0.3 0.6
Sensitivity / hurt feelings 1.7 3.0 5.1 2.0 -1.9 -1.3 2.3 1.5 -2.0 1.0 -1.5
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.3 -0.5 -0.2 0.4 -1.1 -0.6 -0.2 -1.1 0.0
Hearing difficulty/problems: Yes 3.2 4.9 10.8 -3.0 1.9 1.6 -3.3 -2.7 1.7 -1.2 1.1
Relative age of first facial hair 1.7 3.5 6.3 -0.2 2.2 2.5 -2.1 -2.2 2.1 -1.1 1.3
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.7 -1.3 0.8 1.3 -0.5 -0.1 0.9 -0.9 0.5
Ever used hormone-replacement therapy (HRT) 0.4 0.5 2.1 0.8 -0.2 0.2 0.9 1.4 0.2 -0.4 0.2
Ever had hysterectomy (womb removed) 5.0 5.7 9.4 -2.5 2.4 2.2 -3.1 -1.7 2.4 -2.6 1.9
Systolic blood pressure, automated reading 3.0 8.8 11.8 -2.9 3.1 3.4 -0.7 -2.7 3.2 -3.3 3.3
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.4 -0.6 1.0 -0.5 -0.0 -0.1 1.2 -1.1 0.9
Angina 2.1 2.7 8.3 -2.2 1.3 2.9 -0.4 -1.2 1.1 -1.7 1.1
Medication for hormone replacement therapy 0.4 0.4 2.8 -0.3 -0.3 -0.3 0.4 1.7 -0.2 0.1 -0.5
Vitamin and mineral supplements 0.6 0.8 2.4 0.4 -1.1 -0.0 0.1 0.1 -1.5 0.8 -1.5
Supplements: Zinc 0.8 0.9 3.1 1.7 -0.6 -0.7 1.5 0.3 -0.4 0.7 -0.3
Medication: Co-codamol 5.2 6.0 9.5 -2.7 3.1 1.9 -1.3 -1.4 3.0 -2.9 2.6
Medication: Metformin 2.0 2.8 6.1 -1.6 1.5 2.3 -1.1 -2.5 1.7 -0.9 1.2
Diabetes (father) 1.1 1.3 3.4 0.8 -1.4 -1.2 0.9 0.3 -1.3 1.8 -0.9
Diabetes (mother) 4.4 5.7 10.6 -3.3 2.5 1.7 -2.0 -2.0 2.5 -2.6 2.1
Severe depression (siblings) 0.3 0.3 1.5 0.1 -0.3 -0.3 1.2 0.7 -0.3 0.3 -0.3
Pack years adult smoking proportion 2.0 3.0 6.1 -2.5 1.7 0.1 -2.5 -1.5 1.8 -1.4 1.3
Impedance of leg (right) 6.8 32.8 42.0 6.3 -6.1 -5.5 3.6 5.1 -5.8 6.5 -6.2
Leg fat-free mass (left) 7.3 38.7 49.3 -6.2 7.0 6.0 -4.9 -5.8 7.0 -5.9 6.6
Trunk fat percentage 10.9 43.5 60.1 -6.7 7.7 6.2 -6.0 -6.1 7.8 -5.5 6.6
Hand grip strength (right) 3.0 8.2 14.1 -3.3 3.0 3.7 -2.7 -2.4 2.9 -1.7 2.7
Townsend deprivation index at recruitment 7.1 9.9 15.4 -3.0 3.8 1.8 -2.9 -2.6 3.9 -3.3 3.4
Current tobacco smoking 2.7 4.5 6.0 -2.3 2.3 1.9 -1.5 -1.5 2.4 -2.4 2.2
Average weekly fortified wine intake 0.6 0.7 1.7 1.1 -0.5 -1.3 0.3 -0.4 -0.6 1.1 -0.6
Maternal smoking around birth 0.2 0.4 1.2 -0.4 0.2 -0.3 -0.5 -0.5 0.5 -0.8 1.1
Fed-up feelings 0.3 0.5 1.7 0.0 -0.8 0.4 1.3 -0.0 -1.0 -0.1 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 7.6 -1.4 1.3 1.2 -0.9 -1.3 1.3 -2.8 1.4
Relative age voice broke 1.6 2.5 11.3 -0.5 1.0 0.9 -3.4 -2.3 1.0 0.1 0.1
Taking other prescription medications 0.6 1.0 2.6 -1.6 0.9 0.9 -1.3 -0.2 1.1 -0.5 0.3
Age when periods started (menarche) 1.9 4.5 10.6 1.8 -2.5 -0.8 0.2 0.1 -2.5 3.0 -3.2
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 1.1 -0.9 0.9 0.6 -0.8 -0.4 0.7 -1.0 0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 6.4 2.5 -1.4 -1.3 1.1 1.7 -1.2 1.0 -1.2
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.2 -1.3 0.4 0.6 -1.5 -1.3 0.4 0.2 -0.2
Qualifications: CSEs or equivalent 0.9 1.2 3.2 -1.3 1.3 0.9 -0.3 -1.8 1.0 -0.5 1.0
Serious illness, injury or assault to yourself 1.2 1.4 4.5 -0.9 1.0 2.1 -0.4 -0.9 1.1 -1.4 1.0
High blood pressure 8.9 24.8 35.8 -6.0 5.6 5.0 -3.8 -4.5 5.6 -4.4 4.6
Hayfever, allergic rhinitis or eczema 2.4 5.2 10.2 1.5 -2.7 -2.4 0.8 0.9 -2.5 3.2 -2.8
Multivitamins +/- minerals 0.2 0.2 0.5 0.6 0.3 -0.4 -0.1 0.1 0.7 -0.3 0.6
Stomach or abdominal pain in last month 0.2 0.2 1.3 -0.3 -0.0 0.3 0.1 1.1 -0.0 -0.5 -0.1
Supplements: Glucosamine 1.3 1.7 3.6 1.4 -1.1 -1.5 1.2 1.9 -1.0 1.0 -1.1
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.8 0.6 -0.5 0.9 0.3 -0.9 -0.7 -0.2 -0.1
Medication: Atenolol 1.0 1.3 2.9 -1.5 0.9 1.2 -0.5 -0.5 0.9 -1.7 1.1
Medication: Levothyroxine sodium 0.2 0.3 0.6 0.6 -0.5 0.8 0.5 0.5 -0.4 0.5 -0.3
Sitting height 0.1 1.1 4.7 2.2 -0.5 -1.2 0.4 0.9 -0.4 -0.8 0.3
Chronic bronchitis/emphysema (father) 3.2 3.7 8.0 -1.9 2.2 1.3 -2.8 -1.7 2.2 -1.3 1.5
High blood pressure (mother) 2.5 3.6 6.6 -2.6 2.2 1.4 -0.3 -1.7 2.0 -2.1 2.0
Body mass index (BMI) 19.4 82.6 102.9 -9.7 10.1 8.5 -7.3 -8.4 10.1 -8.8 9.4
Impedance of leg (left) 6.1 29.7 38.6 5.9 -5.9 -5.1 3.7 4.9 -5.7 6.2 -5.8
Leg predicted mass (left) 7.3 38.4 49.0 -6.1 7.0 6.0 -4.9 -5.8 7.0 -5.9 6.6
Trunk fat mass 12.2 52.3 71.4 -7.1 8.4 6.9 -6.2 -6.7 8.4 -6.3 7.4
Waist circumference 18.9 69.0 91.2 -8.2 9.4 8.1 -6.8 -8.1 9.6 -7.5 8.5
Number of incorrect matches in round 15.3 25.4 34.1 5.3 -5.8 -3.9 4.6 3.6 -5.8 5.0 -5.6
Past tobacco smoking 3.2 5.9 8.4 1.0 -2.5 -2.3 2.7 2.4 -2.9 2.7 -2.5
Alcohol usually taken with meals 0.5 0.8 1.7 0.2 -0.7 -1.0 0.6 0.3 -0.9 1.2 -1.3
Nervous feelings 6.4 11.9 20.6 3.6 -4.2 -4.0 2.4 2.4 -4.5 2.1 -3.4
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 5.2 2.3 -1.4 -0.8 1.5 0.5 -1.3 -0.8 -0.7
Hearing difficulty/problems with background noise 0.2 0.4 1.9 -0.7 0.1 -0.4 -1.4 -0.5 0.4 0.2 0.1
Hair/balding pattern: Pattern 2 0.7 0.8 3.1 0.7 -0.9 -1.8 -0.2 0.8 -1.0 0.7 -0.2
Had menopause 2.2 2.7 7.6 -0.4 1.3 2.1 -2.3 -2.8 1.3 -0.6 0.6
Had other major operations 3.1 3.7 10.9 -1.1 2.2 3.3 -0.8 -1.0 2.2 -1.6 2.0
Forced vital capacity (FVC) 5.0 19.1 33.2 5.1 -4.5 -2.8 5.8 4.6 -4.7 3.6 -3.2
Heel bone mineral density (BMD) T-score, automated (right) 2.5 5.8 10.7 3.3 -2.6 -1.7 2.1 2.3 -2.5 2.2 -2.4
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.4 0.1 -0.4 -0.2 0.1 -0.1 -0.5 -0.6 -0.2
Qualifications: None of the above 2.3 4.9 10.8 -3.3 1.9 1.8 -1.6 -2.2 1.9 -2.3 2.3
Financial difficulties in last 2 years 10.6 14.3 17.6 -4.1 4.2 3.2 -3.0 -3.5 4.2 -4.0 3.8
Mouth/teeth dental problems 2.9 4.4 7.5 2.7 -2.3 -1.8 1.3 1.4 -2.2 2.4 -2.3
Heart attack 0.6 0.8 2.6 -1.0 0.6 0.5 -1.6 -0.8 0.8 -0.8 0.1
Allergy 0.8 1.8 5.8 0.3 1.1 1.2 1.0 0.4 1.0 -2.4 1.9
Pain all over the body in last month 3.0 3.2 5.9 -2.0 1.9 1.2 -2.4 -1.9 2.0 -1.3 1.1
Diabetes (self-reported) 3.5 5.4 8.9 -1.8 2.7 2.5 -1.1 -2.3 3.0 -2.0 2.6
Hayfever/allergic rhinitis (self-reported) 3.8 5.0 9.5 2.1 -2.5 -2.4 1.0 1.0 -2.5 3.1 -2.5
Medication: Ramipril 6.3 8.1 12.8 -3.4 2.5 3.3 -3.6 -2.9 2.2 -2.3 2.0
Medication: Simvastatin 6.1 9.0 13.1 -3.0 3.1 2.9 -3.6 -2.9 3.1 -2.8 2.4
Fluid intelligence score 2.5 5.1 10.7 -2.0 2.6 0.5 -3.3 -1.6 2.5 -2.7 1.7
Illnesses of siblings 15.0 21.0 25.9 4.6 -5.0 -3.5 4.5 4.7 -5.1 4.4 -4.7
Neuroticism score 2.6 5.5 11.4 2.2 -2.9 -2.2 3.4 1.1 -3.1 0.7 -1.6
Weight 14.0 68.9 89.9 -8.2 9.5 8.2 -6.7 -7.8 9.5 -7.5 8.7
Impedance of arm (right) 8.0 37.5 50.4 6.8 -6.3 -5.3 4.3 5.9 -6.2 7.1 -6.7
Arm fat percentage (right) 14.9 58.6 77.4 -8.0 8.8 7.4 -6.4 -7.2 8.7 -6.8 7.7
Trunk fat-free mass 4.3 24.7 32.7 -4.1 5.5 5.0 -3.6 -4.6 5.7 -5.1 5.7
Hip circumference 20.2 87.2 114.5 -9.1 10.7 9.0 -8.5 -8.6 10.7 -8.4 9.5
Time employed in main current job 0.2 0.3 0.8 0.4 0.4 0.5 0.8 -0.1 0.3 0.9 0.1
Alcohol intake versus 10 years previously 0.5 0.7 1.7 -0.3 0.7 -1.3 -1.2 1.0 0.9 -0.0 0.4
Father’s age at death 3.5 4.7 5.8 2.1 -2.4 -2.3 2.0 2.0 -2.2 2.1 -2.0
Worrier / anxious feelings 2.6 4.8 8.1 2.5 -2.6 -2.6 2.3 1.6 -2.8 -0.2 -1.6
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 5.9 -2.0 1.7 1.6 -1.0 -1.7 1.7 -2.4 1.6
Falls in the last year 6.4 8.6 12.6 -1.9 3.5 3.0 -1.9 -3.6 3.5 -2.7 2.9
Hair/balding pattern: Pattern 3 0.8 1.2 5.9 -0.2 1.1 0.8 -2.4 -0.9 1.0 -0.1 -0.1
Number of live births 0.7 1.0 3.6 -1.0 0.6 0.7 -1.0 -1.9 0.5 -0.9 0.5
Forced expiratory volume in 1-second (FEV1) 5.3 18.0 25.6 5.1 -4.5 -3.3 5.1 4.3 -4.8 3.1 -3.2
Pulse rate 0.2 0.4 2.1 -0.4 -0.3 0.3 -0.2 0.2 -0.3 1.5 -0.4
Happiness 3.1 3.8 6.9 1.9 -2.6 -0.8 1.3 1.2 -2.5 1.7 -2.6
Noisy workplace 0.2 0.2 1.0 -0.6 0.1 0.3 1.0 0.1 0.1 -0.5 0.3
Qualifications: A levels/AS levels or equivalent 4.6 10.1 15.4 3.9 -2.8 -3.0 0.6 3.8 -2.8 3.7 -3.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.0 0.8 -0.4 -0.7 0.2 1.0 -0.4 0.5 -0.5
Mouth/teeth dental problems: Dentures 1.1 1.8 4.5 -2.1 1.2 1.7 0.3 -0.6 1.2 -1.7 1.1
Asthma 1.0 2.0 4.2 -1.6 1.4 1.8 -2.1 -1.5 1.3 0.5 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.7 -0.7 0.8 -0.3 -1.3 -0.2 0.7 -0.3 0.7
Medication: Cholesterol lowering 8.3 12.8 14.7 -3.7 3.8 3.7 -3.8 -3.5 3.8 -3.2 3.1
Depression (self-reported) 0.2 0.2 0.6 -0.4 -0.0 0.4 -0.2 -0.1 0.1 -0.8 0.8
Medication: Lansoprazole 2.1 2.4 8.1 -2.8 1.6 0.3 -1.4 -0.6 1.3 -1.6 1.3
Prospective memory result 1.2 1.5 7.2 1.2 -1.1 0.3 2.7 0.6 -0.9 0.7 -0.7
Lung cancer (father) 0.6 0.7 1.4 0.8 -0.5 1.0 1.2 -0.5 -0.7 0.6 -1.0
Illnesses of mother 2.3 2.8 8.3 2.9 -1.7 -0.6 1.8 0.6 -1.6 1.5 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 7.7 24.4 39.5 6.3 -5.6 -3.7 4.9 4.0 -5.8 4.1 -4.5
Pulse wave Arterial Stiffness index 4.9 5.8 8.9 -2.3 3.0 2.2 -1.7 -1.4 3.0 -2.4 2.8
Impedance of arm (left) 7.6 35.4 50.3 6.5 -6.2 -5.0 4.0 5.3 -6.0 7.1 -6.7
Arm fat mass (right) 16.4 67.4 89.1 -8.3 9.4 8.0 -6.5 -7.5 9.4 -7.6 8.6
Trunk predicted mass 4.2 24.1 31.8 -4.0 5.5 5.0 -3.6 -4.6 5.6 -5.0 5.6
Standing height 0.3 2.7 9.1 3.0 -1.2 -0.2 1.1 1.0 -0.9 2.5 -1.4
Length of working week for main job 0.2 0.2 0.5 0.6 -0.7 0.1 0.1 -0.5 -0.6 0.4 -0.4
Exposure to tobacco smoke at home 0.6 0.7 1.4 -0.7 1.1 1.2 -0.7 -0.5 0.9 -0.5 0.8
Breastfed as a baby 0.7 0.9 2.9 -0.6 0.3 0.5 -1.7 -1.4 0.9 0.8 -0.4
Tense / ‘highly strung’ 5.9 9.7 18.5 3.3 -4.1 -2.5 3.4 1.5 -4.3 2.0 -2.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.6 0.8 -1.1 -0.9 1.1 -0.4 -1.3 0.2 -0.4
Hair/balding pattern: Pattern 4 0.3 0.6 2.3 -1.5 0.4 0.6 0.6 -0.1 0.5 -1.2 0.6
Birth weight of first child 1.1 2.0 3.7 -1.3 1.7 1.7 -1.4 -1.4 1.9 -0.3 1.1
Peak expiratory flow (PEF) 0.2 0.5 1.4 1.0 -0.6 -0.4 1.2 1.0 -0.7 0.0 -0.1
Pulse wave reflection index 3.2 4.0 7.3 -2.0 2.2 1.2 -1.2 -1.2 2.4 -2.7 2.3
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.2 1.4 -1.5 -0.2 1.2 1.2 -1.4 0.7 -1.1
Loud music exposure frequency 2.5 2.7 6.0 -1.7 1.5 0.4 -2.4 -1.1 1.3 -2.5 1.3
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 3.0 1.7 -0.6 -1.0 0.8 1.2 -0.8 1.6 -1.1
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.0 -1.1 0.9 0.4 -0.9 -1.4 0.8 -0.2 0.8
Blood clot in the leg (DVT) 1.0 1.4 6.8 -1.4 0.6 -0.5 -2.6 -0.9 0.3 -0.7 0.2
Medication: Paracetamol 4.4 7.3 11.2 -3.2 3.4 2.5 -2.2 -1.6 3.2 -2.6 2.7
Headache pain in last month 3.0 5.1 7.2 -2.4 2.7 2.1 -2.3 -1.3 2.6 -2.4 2.2
Medication for cholesterol, blood pressure or diabetes 5.4 9.0 10.6 3.1 -3.3 -3.1 2.4 2.7 -3.3 3.1 -2.9
Glaucoma (self-reported) 1.5 1.8 5.8 1.3 -1.0 -1.1 2.4 1.2 -1.3 1.1 -0.8
Gout (self-reported) 2.2 3.0 5.1 1.3 -2.2 -1.9 0.7 1.5 -1.9 1.8 -2.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 0.9 0.9 -0.9 0.5 0.9 0.9 -0.7 0.6 -0.6
Medication: Amlodipine 0.2 0.3 1.3 -0.5 0.3 1.2 0.6 -0.4 0.2 -0.5 0.5
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.9 -0.3 0.6 0.8 0.2 0.0 0.2 1.0 0.1
Birth weight 3.1 6.6 9.5 -1.8 2.8 3.1 -1.5 -3.1 2.8 -2.7 2.5
Chronic bronchitis/emphysema (mother) 1.4 1.7 5.1 -1.4 1.4 -0.3 -2.2 -0.7 1.6 -0.8 0.7
High blood pressure (siblings) 14.4 20.8 28.8 -4.5 5.3 3.5 -3.8 -4.7 5.4 -4.1 4.8
Forced vital capacity (FVC), Best measure 5.9 21.6 35.6 6.0 -5.2 -2.9 5.3 3.9 -5.2 4.0 -4.0
Body fat percentage 13.2 52.2 69.6 -7.5 8.3 6.7 -6.5 -6.8 8.3 -6.2 7.2
Leg fat percentage (right) 13.2 47.8 61.1 -7.4 7.8 6.1 -6.4 -6.7 7.8 -6.0 6.8
Arm fat-free mass (right) 7.7 39.4 50.3 -6.1 6.9 5.9 -5.1 -5.9 7.1 -6.1 6.8
Exposure to tobacco smoke outside home 5.2 6.9 10.3 -3.1 3.2 1.7 -2.0 -1.1 3.2 -2.9 3.0
Comparative body size at age 10 5.5 15.3 22.9 -4.8 4.2 3.7 -4.6 -3.7 4.3 -1.9 3.2
Number of full brothers 5.4 6.7 10.4 -2.8 3.0 1.6 -1.9 -1.1 3.2 -3.0 3.2
Worry too long after embarrassment 1.3 2.2 4.5 2.0 -1.7 -0.3 2.1 0.6 -1.8 1.2 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 3.2 1.8 -1.5 -0.5 1.2 -0.0 -1.4 0.7 -0.8
Wheeze or whistling in the chest in last year 7.1 12.7 20.2 -4.5 4.1 3.7 -3.4 -3.5 3.7 -2.6 2.8
Number of children fathered 0.6 0.6 2.0 -0.9 0.3 0.5 -1.4 -0.8 0.2 -1.1 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 3.4 1.8 -0.9 0.1 0.9 -0.8 -0.8 1.0 -0.5
Age at first live birth 4.1 7.2 9.8 2.6 -3.1 -1.7 2.2 2.3 -3.0 3.1 -3.0
Pulse wave peak to peak time 5.5 6.5 9.9 2.6 -3.2 -2.2 1.7 1.4 -3.1 2.6 -3.0
Health satisfaction 4.3 5.6 9.7 -3.1 2.2 1.6 -1.8 -1.4 2.4 -3.1 2.6
Shortness of breath walking on level ground 3.2 3.8 8.0 -2.0 2.0 0.8 -1.9 -2.0 1.8 -2.8 1.8
Qualifications: College or University degree 4.4 13.8 20.4 4.5 -4.1 -3.5 1.1 3.5 -3.8 3.8 -4.3
Eye problems/disorders: None of the above 0.6 0.6 1.5 -1.2 0.5 1.0 -1.2 -0.5 0.5 -0.7 0.2
Mouth/teeth dental problems: Loose teeth 3.5 4.2 7.3 -1.3 2.6 2.0 -0.0 -1.8 2.7 -1.9 2.7
Emphysema/chronic bronchitis 2.4 2.6 4.2 -1.5 2.0 1.9 -0.9 -2.0 1.9 -0.9 1.3
Medication for pain relief, constipation, heartburn 2.3 4.0 9.6 3.1 -2.0 -1.4 2.6 1.1 -2.1 1.5 -1.2
Neck or shoulder pain in last month 3.2 4.6 9.0 -2.3 2.3 3.0 -1.4 -1.7 2.4 -1.8 1.8
Medication: Blood pressure 3.9 6.9 10.1 -3.0 2.7 3.2 -1.2 -2.3 2.8 -2.6 2.8
Angina (self-reported) 2.2 3.0 8.7 -2.3 1.3 3.0 -0.5 -1.4 1.2 -1.8 1.1
Migraine (self-reported) 0.6 0.8 1.6 -0.2 0.9 0.3 0.0 -0.8 1.1 -1.3 1.3
Medication: Ibuprofen 0.3 0.3 1.8 0.0 0.5 -0.2 -1.3 -0.4 0.4 0.1 0.2
Medication: Allopurinol 3.7 4.9 8.9 1.4 -2.7 -3.0 1.2 1.9 -2.4 1.8 -2.6
Medication: Omeprazole 0.3 0.3 1.1 -0.2 -0.4 0.2 0.6 1.1 -0.2 0.6 -0.5
Medication: Seretide 50 evohaler 0.1 0.2 0.8 0.2 -0.0 -0.9 0.1 0.5 -0.1 0.3 -0.3
Mean time to correctly identify matches 0.1 0.2 0.6 -0.5 0.5 -0.3 0.4 -0.7 0.5 -0.2 0.0
Heart disease (mother) 0.6 0.7 2.9 -1.7 0.4 -0.2 0.3 0.8 0.5 -0.9 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.1 3.6 8.1 -2.8 1.8 1.0 -2.8 -1.2 1.8 -1.6 1.4
Whole body fat mass 14.3 59.5 79.6 -7.8 8.9 7.3 -6.4 -7.2 8.9 -6.9 7.9
Leg fat mass (right) 15.8 61.3 80.1 -8.2 8.8 7.1 -6.8 -7.5 8.9 -7.0 8.0
Arm predicted mass (right) 7.8 40.0 51.3 -6.0 7.0 6.0 -5.2 -6.2 7.2 -6.1 6.8
Pulse rate, automated reading 1.0 3.3 7.3 -2.2 1.8 1.1 -2.2 -2.7 1.8 0.6 1.1
Alcohol intake frequency. 9.9 23.0 29.7 -5.4 5.5 4.9 -2.9 -4.2 5.3 -4.9 4.9
Comparative height size at age 10 0.1 0.7 2.5 0.7 0.3 0.6 1.6 1.1 0.8 0.3 0.3
Number of full sisters 3.9 4.7 7.8 -2.7 2.6 2.8 -0.7 -2.0 2.6 -1.0 1.9
Suffer from ‘nerves’ 2.3 3.5 6.3 2.2 -2.3 -2.2 0.9 1.3 -2.5 0.2 -2.0
Overall health rating 12.7 27.2 36.9 -5.6 6.1 4.2 -4.6 -3.8 6.0 -5.7 5.1
Chest pain or discomfort 4.5 6.4 9.7 -3.1 2.6 2.3 -3.1 -1.8 2.5 -2.4 2.1
Had major operations 2.4 2.9 4.5 -1.7 1.9 1.2 -1.1 -1.6 2.1 -1.9 1.8
Age at last live birth 1.4 2.0 3.3 1.7 -1.7 -0.5 1.3 0.7 -1.6 1.4 -1.8
Family relationship satisfaction 0.5 0.6 1.3 1.1 -0.3 0.2 -1.1 -0.0 -0.2 1.1 -0.9
Leg pain on walking 1.2 1.5 3.0 -0.5 0.8 1.0 1.7 -0.8 0.9 -1.5 1.7
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 3.4 0.5 1.4 0.6 0.2 -0.5 1.4 -1.8 1.5
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.3 0.3 0.6 0.9 0.3 -0.4 0.8 -1.5 1.3
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.3 0.8 -1.2 -1.8 0.2 0.6 -1.3 1.8 -1.4
Medication: Aspirin 3.7 4.9 6.4 -2.4 2.1 2.4 -2.5 -2.4 2.2 -2.0 1.7
Supplements: Vitamin C 0.7 0.8 2.6 1.6 -0.4 -1.0 1.4 0.6 -0.1 0.4 -0.2
Knee pain experienced in last month 9.3 14.4 19.5 -3.9 4.4 3.5 -3.9 -3.3 4.2 -3.6 3.5
Hypertension (Self-reported) 8.4 23.3 31.9 -5.7 5.4 4.9 -3.8 -4.4 5.5 -4.2 4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 4.2 0.5 -1.0 -1.1 2.0 1.0 -1.1 1.5 -0.9
Illnesses of father: Heart disease 0.3 0.4 0.9 -0.1 0.7 -0.5 0.7 0.7 0.8 -1.0 0.5
Illnesses of siblings: Diabetes 2.7 3.3 5.0 -1.3 2.0 1.0 -2.0 -1.8 2.1 -2.2 1.8
Smoking status: Previous 2.9 4.3 7.3 -0.6 2.0 1.9 -2.7 -2.3 2.3 -2.1 1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 2.4 1.5 -0.8 -0.5 0.9 0.0 -0.9 0.6 -0.7
Whole body fat-free mass 5.9 33.7 43.2 -5.3 6.5 5.7 -4.3 -5.4 6.6 -5.8 6.5
Leg fat-free mass (right) 6.9 37.0 46.2 -6.0 6.8 6.1 -4.6 -5.7 6.8 -5.9 6.5
Arm fat percentage (left) 14.7 58.8 76.7 -8.1 8.8 7.3 -6.4 -7.3 8.7 -6.8 7.7
Average weekly red wine intake 0.2 0.3 1.1 0.3 -0.7 -0.6 0.1 1.1 -0.5 0.1 -0.6
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.5 -0.7 1.5 0.7 -1.1 -0.9 1.6 -0.7 1.4
Mood swings 0.6 1.1 3.7 0.6 -1.3 0.0 1.9 -0.5 -1.5 -0.3 -0.3
Loneliness, isolation 0.7 1.0 4.3 -0.7 0.4 0.4 0.1 -0.9 0.5 -2.1 1.4
Long-standing illness, disability or infirmity 1.4 2.2 4.6 -2.2 1.8 1.3 -1.3 -0.5 1.8 -1.3 1.0
Ever had bowel cancer screening 0.4 0.5 1.9 -0.3 0.1 0.5 -0.9 -1.4 0.3 -0.8 0.3
Diabetes diagnosed by doctor 4.2 6.9 10.4 -2.7 3.0 2.6 -1.9 -2.3 3.2 -2.5 2.7
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.8 0.7 -0.8 -1.3 0.7 0.9 -0.5 0.0 -0.4
Friendships satisfaction 1.5 1.9 2.4 1.3 -1.5 -1.2 0.9 1.3 -1.6 1.5 -1.5
Qualifications: nursing, teaching 2.1 3.3 5.3 1.8 -1.9 -1.4 1.3 2.3 -1.6 1.9 -2.2
Commuting to job workplace: Walk 2.8 3.0 5.1 2.0 -1.6 -2.2 1.1 -0.4 -1.7 2.3 -1.9
Eye problems/disorders: Cataract 0.1 0.1 0.4 0.2 0.6 -0.2 -0.2 -0.5 0.5 -0.1 0.4
Mouth/teeth dental problems: Mouth ulcers 2.4 3.9 6.5 -1.0 2.4 1.1 -2.0 -1.3 2.4 -2.6 2.2
Medication for cholesterol 6.8 10.3 16.7 4.1 -3.7 -3.1 2.9 2.1 -3.9 2.7 -2.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 1.8 -1.0 0.5 0.5 1.4 1.0 1.0 -1.4 1.0
Back pain experienced in last month 0.7 1.0 2.7 -1.6 1.2 0.4 -1.3 -0.0 1.2 -0.7 0.6
Mineral and other dietary supplements 1.0 1.4 4.0 -0.9 1.0 2.0 -0.8 -1.6 0.8 -1.0 0.6
Breast cancer (self-reported) 0.6 0.7 2.2 0.2 -0.8 0.7 0.5 0.0 -1.1 1.5 -0.9
Asthma (self-reported) 0.9 1.8 3.6 -1.6 1.4 1.7 -1.9 -1.2 1.2 0.5 -0.1
Osteoporosis (self-reported) 0.9 1.1 3.7 -0.4 1.2 -0.2 -1.9 -0.9 1.3 -0.7 0.7
Osteoarthritis (self-reported) 0.4 0.5 3.1 0.6 -0.1 0.3 1.8 0.6 -0.1 0.5 -0.3
Medication: Aspirin 3.2 4.2 6.2 -2.0 1.8 2.5 -2.2 -2.3 1.9 -2.0 1.5
Medication: Gliclazide 0.6 0.7 1.5 -0.0 1.0 1.2 0.3 -0.6 1.2 -0.3 1.2
Illnesses of father: None of the above (group 1) 1.4 1.7 3.5 1.9 -1.4 0.4 1.2 0.4 -1.6 1.5 -1.3
Smoking status: Current 1.8 2.8 4.2 -1.8 1.7 1.5 -1.2 -1.2 1.9 -2.0 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 13.2 28.0 38.2 6.2 -5.8 -4.4 5.7 4.9 -6.1 4.0 -4.8
Whole body water mass 5.8 33.0 42.5 -5.3 6.4 5.7 -4.3 -5.3 6.5 -5.7 6.4
Leg predicted mass (right) 6.9 36.6 46.0 -5.9 6.8 6.1 -4.6 -5.7 6.8 -5.8 6.5
Arm fat mass (left) 16.8 68.9 90.2 -8.4 9.5 8.1 -6.7 -7.6 9.5 -7.6 8.6
Number of self-reported non-cancer illnesses 3.6 6.3 13.1 -3.6 2.7 2.2 -2.7 -1.8 2.8 -1.7 2.0
Average weekly champagne plus white wine intake 0.9 1.3 3.2 -0.7 0.9 0.1 -1.8 -1.5 0.9 -1.3 0.7
Miserableness 0.2 0.4 1.4 0.4 -0.9 -0.2 0.7 -0.2 -1.2 -0.5 -0.4
Guilty feelings 0.2 0.4 2.2 0.0 -0.3 -0.0 1.5 0.2 -0.6 -0.4 0.3
Wears glasses or contact lenses 0.8 0.9 1.8 -0.3 1.1 0.7 -0.3 -1.3 1.4 -0.6 1.3
Ever taken oral contraceptive pill 0.5 0.5 1.1 -0.9 0.7 -0.5 0.1 -0.1 1.0 -0.8 1.0
Hearing aid user 4.0 4.5 7.6 -2.8 2.4 1.6 -1.8 -0.9 2.0 -2.5 2.4
Mother’s age at death 0.2 0.2 0.6 0.8 -0.6 0.4 0.3 -0.3 -0.5 0.5 -0.3
Financial situation satisfaction 1.8 2.3 4.6 -0.8 1.2 2.1 -1.3 -1.5 1.3 -1.8 1.5
Tinnitus: Yes, now most or all of the time 2.1 2.4 5.4 -0.9 1.2 1.5 -2.0 -2.3 1.2 -1.4 1.5
Commuting to job workplace: Public transport 0.2 0.3 0.7 -0.2 0.7 0.1 -0.8 -0.6 0.5 -0.0 0.4
Eye problems/disorders: Glaucoma 2.6 3.1 7.8 1.2 -1.6 -1.5 2.8 1.8 -1.8 1.7 -1.1
Medication: Blood pressure 5.9 11.2 15.6 -4.0 3.8 3.9 -2.6 -2.8 3.8 -2.6 3.0
Pain type(s) experienced in last month: Hip pain 1.3 1.7 4.2 -1.1 1.5 2.1 -0.0 -1.3 1.4 -1.0 1.0
Supplements: Fish oil (including cod liver oil) 1.4 1.9 4.1 0.8 -1.3 -2.0 1.4 2.0 -1.3 0.7 -0.5
High cholesterol (Self-reported) 8.0 14.2 25.1 -5.0 3.7 3.6 -4.3 -3.2 3.8 -3.0 3.1
Medication: Bendroflumethiazide 7.7 11.6 17.9 -4.1 3.9 4.2 -1.5 -3.3 3.8 -2.4 3.2
Medication: Paracetamol 3.9 6.1 9.3 -2.5 3.1 1.9 -2.5 -1.8 2.8 -2.6 2.3
Medication: Lisinopril 1.4 1.8 3.3 -1.4 1.5 1.1 -0.4 -1.6 1.8 -0.6 1.7
Medication: Atorvastatin 7.6 9.4 19.7 -4.4 2.9 2.9 -3.7 -2.8 2.9 -2.2 2.1
Illnesses of father: High blood pressure 4.2 5.2 8.9 -2.4 2.6 0.9 -1.5 -1.6 2.8 -3.0 2.6
Alcohol drinker status: Never 0.1 0.1 0.5 -0.4 0.3 -0.1 -0.3 -0.7 -0.2 -0.1 0.2
Ever smoked 2.3 4.1 6.7 -0.5 2.2 1.9 -1.7 -1.8 2.6 -2.5 2.2
Basal metabolic rate 7.8 43.3 56.6 -6.2 7.4 6.5 -5.0 -6.1 7.5 -6.3 7.2
Leg fat percentage (left) 14.3 51.7 64.8 -7.9 8.1 6.5 -6.5 -7.0 8.0 -6.2 7.1
Arm fat-free mass (left) 8.5 43.3 56.6 -5.9 7.4 6.5 -5.0 -6.1 7.5 -6.5 7.3
Number of operations (self-reported) 3.6 5.3 7.7 -2.7 2.5 2.8 -1.3 -1.3 2.8 -2.2 2.2
Average weekly beer plus cider intake 0.8 1.1 2.5 1.6 -1.2 -1.1 0.0 1.4 -1.1 0.3 -0.7
Irritability 4.1 7.0 16.2 2.6 -3.2 -2.5 4.0 1.6 -3.0 1.1 -1.9
Risk taking 0.9 1.3 2.4 -0.4 1.0 1.3 -1.2 -1.5 1.1 -1.1 1.1
Ever had prostate specific antigen (PSA) test 0.2 0.3 1.3 -0.2 -0.4 -0.5 0.5 1.1 -0.4 -0.0 -0.3
Fractured/broken bones in last 5 years 7.6 9.9 25.4 -2.2 3.1 2.0 -5.0 -3.1 3.2 -2.9 2.6
Age started oral contraceptive pill 0.1 0.1 0.4 0.1 -0.1 0.1 -0.2 -0.5 -0.1 0.6 -0.4
Diastolic blood pressure, automated reading 8.1 25.1 34.6 -5.5 5.7 5.9 -4.0 -5.0 5.4 -3.7 4.5
Ever depressed for a whole week 1.0 1.2 2.2 1.3 -1.5 -1.4 0.7 0.1 -1.5 0.6 -1.2
Unable to work because of sickness or disability 9.8 12.6 16.1 -3.1 4.0 3.8 -2.0 -3.5 4.0 -4.0 3.6
Commuting to job workplace: Cycle 0.5 0.5 1.4 1.2 -0.7 -0.9 -0.1 0.2 -0.4 0.7 -1.0
Myopia 3.2 4.6 10.0 -2.7 2.2 1.4 -3.2 -2.1 2.1 -1.1 1.5
Vascular/heart problems diagnosed by doctor 10.7 29.0 41.5 6.4 -5.8 -5.6 4.4 5.1 -5.9 4.8 -4.7
Cholesterol lowering medication 11.1 16.3 24.5 -4.9 4.1 3.8 -5.0 -3.4 4.2 -3.5 3.0
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.0 -0.6 -0.3 0.2 0.6 1.0 -0.3 0.7 -0.8
Pain experienced in last month 7.4 12.3 17.2 3.8 -4.1 -3.6 3.9 2.6 -3.9 2.9 -2.9
Supplements: Calcium 0.1 0.1 0.5 0.2 0.2 0.0 -0.5 -0.7 0.5 -0.3 0.1
Basal cell carcinoma (self-reported) 0.6 0.8 1.5 0.9 -1.2 -0.9 0.9 -0.1 -0.9 0.9 -0.7
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.8 -1.0 0.5 0.6 -1.7 -0.9 0.6 -0.7 -0.0
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 6.5 -1.4 0.5 -0.5 -2.5 -1.1 0.4 -0.7 0.1
Heart disease (siblings) 6.4 7.8 12.5 -2.4 2.9 3.1 -1.9 -2.1 2.9 -3.5 3.2
Alcohol drinker status: Previous 5.1 5.8 8.0 -2.4 2.6 2.5 -1.5 -2.3 2.5 -2.8 2.4
Pack years of smoking 2.3 3.4 6.9 -2.6 1.8 0.1 -2.6 -1.7 1.9 -1.4 1.4
Impedance of whole body 7.9 40.1 54.9 6.9 -6.7 -5.6 4.3 5.8 -6.5 7.4 -7.0
Leg fat mass (left) 16.0 62.5 80.1 -8.4 8.9 7.2 -6.8 -7.6 8.9 -7.1 8.0
Arm predicted mass (left) 8.9 45.4 59.3 -6.3 7.5 6.3 -5.3 -6.2 7.7 -6.7 7.4