TWAS hub - HACL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2260	0.0960	3.5e-03	0.040	NA	0.069	NA	0.133	1.9e-02	NA	2.8e-03	NA	4.3e-05
2	GTEx	Esophagus Mucosa	0.2100	0.0570	1.3e-04	0.014	NA	0.070	NA	0.035	3.5e-02	NA	1.8e-05	NA	2.0e-03
3	GTEx	Testis	0.4610	0.0750	1.1e-08	0.244	NA	0.346	NA	0.337	3.2e-11	NA	3.9e-16	NA	1.2e-15
4	YFS	Blood	0.2469	0.0388	0.0e+00	0.059	0.091	0.113	0.111	0.108	1.2e-18	4.5e-28	4.6e-35	3.1e-34	2.8e-33
5	TCGA	Breast Invasive Carcinoma	0.0397	0.0220	3.3e-03	0.005	0.010	0.012	NA	0.010	2.5e-02	2.7e-03	1.1e-03	NA	3.6e-03
6	TCGA	Lung Adenocarcinoma	0.0837	0.0470	1.6e-03	0.024	0.008	0.006	NA	0.009	7.5e-04	3.3e-02	6.0e-02	NA	2.6e-02
7	TCGA	Soft Tissue Sarcoma	0.0960	0.0540	9.5e-04	0.015	0.052	0.049	NA	0.038	4.1e-02	5.1e-04	7.1e-04	NA	2.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Ever had hysterectomy (womb removed)	5.0	5.7	9.9	2.4	3.1	2.7	2.7	2.6	1.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	4.0	5.2	8.5	2.7	1.6	2.1	2.9	2.9	1.7	1.5
Ever had bowel cancer screening	3.9	4.6	11.4	1.6	1.0	3.4	1.3	3.0	2.2	-1.4
Blood clot in the leg (DVT)	3.5	4.5	7.8	2.6	1.5	2.0	2.6	2.8	1.4	1.4
Pulse wave Arterial Stiffness index	3.4	4.0	6.6	2.2	1.8	2.2	2.0	2.6	1.9	0.8
Pulse rate, automated reading	3.4	11.1	40.3	-4.0	-3.4	-0.2	-2.2	-1.3	-1.8	-6.3
Pulse wave peak to peak time	3.3	3.8	6.9	-2.1	-1.7	-2.1	-2.1	-2.6	-1.8	-0.7
Rheumatoid Arthritis	2.8	3.9	7.0	-2.2	-2.1	-2.0	-1.3	-2.3	-2.6	-0.4
Had menopause	2.7	3.4	6.6	0.6	1.3	2.4	2.0	2.6	0.5	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	8.2	1.2	0.1	2.9	1.2	2.2	2.3	-0.9
Had major operations	2.4	2.8	5.3	-2.3	-0.9	-1.5	-1.1	-1.2	-2.1	-2.1
Average weekly champagne plus white wine intake	2.4	3.3	12.3	1.6	0.9	2.3	0.1	1.0	3.5	1.0
Illnesses of father: High blood pressure	2.4	2.9	5.1	-1.4	-2.3	-1.9	-1.9	-1.7	-1.8	-0.3
Maternal smoking around birth	2.2	3.2	6.8	1.3	0.9	2.3	2.2	2.6	1.2	-1.0
Supplements: Glucosamine	2.2	2.9	6.5	2.2	2.5	1.7	1.2	1.4	1.6	0.2
Time employed in main current job	2.2	2.5	8.4	2.4	0.8	0.8	1.1	0.5	0.9	2.9
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	4.3	-1.9	-1.9	-2.1	-1.7	-1.6	-1.8	-0.1
LDL Cholesterol	2.1	3.3	6.0	-2.4	-1.3	-1.9	-1.7	-1.0	-1.8	-2.0
Pulse wave reflection index	2.1	2.6	4.8	1.2	2.2	1.8	1.4	1.8	1.1	1.5
Diverticular disease/diverticulitis (self-reported)	2.0	2.3	4.3	2.1	2.0	1.3	0.1	1.1	1.6	1.5
Happiness	1.9	2.3	5.2	1.7	1.1	0.6	0.2	1.2	2.2	2.3
Leg pain on walking	1.9	2.4	5.0	1.0	1.7	1.9	1.6	2.2	0.9	-0.9
Medication: Lisinopril	1.9	2.5	3.7	-1.6	-1.2	-1.7	-1.9	-1.9	-1.8	-0.3
Alcohol drinker status: Never	1.9	2.3	8.6	0.7	2.9	0.8	1.0	1.9	0.2	1.4
Type 2 Diabetes (T2D) (2012)	1.8	2.1	6.1	1.2	1.0	1.5	2.5	1.9	0.0	-0.3
Relative age voice broke	1.8	2.8	5.0	-1.9	0.6	-2.2	-1.7	-1.4	-2.1	-1.2
Mouth/teeth dental problems	1.8	2.8	9.5	2.1	3.1	1.4	0.8	0.7	1.5	0.8
Pulse rate	1.8	3.0	7.0	-1.7	-2.4	-0.9	-1.9	-1.1	-0.3	-2.6
Ever highly irritable/argumentative for 2 days	1.8	2.1	4.2	-1.8	-1.1	-0.8	-1.7	-0.0	-1.7	-2.1
Illness, injury, bereavement, stress in last 2 years	1.8	2.1	6.0	1.1	1.4	0.6	0.3	0.6	2.5	2.2
Medication: Atorvastatin	1.8	2.3	7.7	-1.0	1.4	1.2	0.9	1.7	-0.3	-2.8
Depression (Nagel 2018)	1.7	2.6	4.8	1.6	2.1	0.7	1.0	0.4	2.2	2.1
Average weekly fortified wine intake	1.7	2.0	4.8	0.8	2.2	1.6	1.1	1.4	1.4	-0.8
Back pain experienced in last month	1.7	2.5	4.7	-2.0	-2.2	-1.1	-1.3	-0.7	-1.2	-2.0
Ever used hormone-replacement therapy (HRT)	1.6	2.1	3.2	0.6	1.5	1.5	1.7	1.7	-0.6	-1.8
Qualifications: CSEs or equivalent	1.6	2.1	4.6	-0.9	-1.6	-2.1	-1.5	-0.9	-1.8	0.7
Serious illness, injury or assault to yourself	1.6	2.0	4.7	0.2	1.1	1.7	1.2	1.9	-0.4	-2.2
Forced vital capacity (FVC), Best measure	1.6	5.9	11.2	-0.7	-1.8	-2.9	-3.3	-3.3	0.3	2.7
Mean time to correctly identify matches	1.6	3.0	7.4	1.5	1.0	2.7	1.6	1.8	1.9	-1.0
Taking other prescription medications	1.5	2.3	9.1	-1.1	-0.2	0.9	1.2	1.1	-1.6	-3.0
Hair/balding pattern: Pattern 3	1.5	2.2	4.1	-2.0	-1.4	-1.7	-0.7	-1.9	-1.4	-0.4
Prospective memory result	1.5	1.9	4.2	1.1	2.0	0.9	1.2	2.0	1.1	0.6
Length of working week for main job	1.5	1.6	3.8	-0.7	-1.2	-2.0	-1.4	-1.7	-0.2	0.6
Breastfed as a baby	1.5	1.9	3.8	-2.0	-1.9	-1.6	-0.8	-1.0	-1.0	-0.8
Medication: Omeprazole	1.5	1.8	3.2	1.3	1.6	1.8	1.1	1.8	0.5	-0.7
Number of full sisters	1.5	1.8	4.5	-2.1	0.4	-1.4	-1.2	-1.3	-1.6	-0.8
Alcohol drinker status: Previous	1.5	1.7	3.7	-1.1	-1.3	-1.1	-0.4	-1.9	-1.8	-0.8
HDL Cholesterol	1.4	2.3	6.4	0.1	-0.1	-1.3	-0.9	-2.4	1.1	2.5
Relative age of first facial hair	1.4	3.0	8.1	-0.4	-0.7	-2.9	-2.0	-1.4	-1.6	1.8
Medication: Atenolol	1.4	1.7	4.7	-2.2	-1.7	-0.2	0.5	0.9	-1.1	-1.6
Falls in the last year	1.4	1.9	4.9	0.5	0.5	1.6	1.5	2.2	0.2	-1.7
Lung cancer (father)	1.4	1.7	3.1	1.3	0.3	1.5	0.8	1.1	1.6	1.8
Birth weight	1.4	3.0	7.0	2.1	1.0	0.4	-1.1	-1.9	2.6	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	6.1	1.3	2.5	0.0	1.5	1.2	-0.3	1.0
Health satisfaction	1.4	1.8	6.2	1.1	2.5	0.5	1.6	1.3	0.9	0.0
Ovarian Cancer	1.3	1.7	2.8	-1.2	-1.3	-1.6	-1.0	-1.7	-1.4	-0.9
Neuroticism (2016)	1.3	1.9	3.9	1.2	0.2	1.7	1.0	1.0	2.0	1.8
Triglycerides	1.3	2.1	5.8	-1.8	-0.8	-0.9	-0.7	0.4	-2.4	-2.0
High blood pressure (mother)	1.3	1.8	4.0	-0.8	-1.6	-1.7	-0.9	-2.0	-1.0	0.8
Forced vital capacity (FVC)	1.3	5.1	10.8	-1.1	-2.3	-2.6	-3.0	-3.3	-0.2	1.5
Medication: Simvastatin	1.3	2.0	5.7	0.3	-0.6	2.4	1.2	1.3	-0.1	-2.2
Medication for pain relief, constipation, heartburn	1.3	2.2	4.9	-0.7	-2.2	-1.3	-1.5	-2.2	-0.6	-0.9
Chest pain or discomfort	1.3	1.8	4.0	-1.2	-2.0	-1.1	-0.2	-0.9	-1.6	-1.7
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.8	-1.7	-1.1	-1.7	-0.8	-1.1	-1.6	-0.3
Number of treatments/medications taken	1.2	2.1	4.9	0.1	0.8	1.7	1.8	1.7	-0.7	-2.2
Frequency of depressed mood in last 2 weeks	1.2	1.7	6.0	1.5	1.2	-0.7	0.4	-0.4	1.2	2.4
Medication: Cholesterol lowering	1.2	1.9	6.8	-0.5	-0.2	1.6	1.4	1.1	-0.5	-2.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	4.0	8.3	-0.1	-0.6	-2.6	-2.5	-2.5	0.3	2.9
Loud music exposure frequency	1.2	1.3	4.8	0.9	0.2	0.9	-0.4	0.3	2.2	1.6
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	4.6	-1.0	-0.3	-1.7	-2.1	-1.9	-0.7	0.2
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	5.7	0.2	-0.2	-1.2	-2.4	-1.3	1.3	1.9
Medication: Amlodipine	1.2	1.6	2.8	-1.7	-1.0	-1.0	-1.0	-1.3	-1.2	-1.6
Number of children fathered	1.2	1.3	3.7	0.4	0.1	1.1	1.9	1.7	-0.7	-0.7
Financial situation satisfaction	1.2	1.5	3.5	1.3	1.2	-0.1	-0.8	0.6	1.8	1.9
Medication: Blood pressure	1.2	2.2	4.7	-2.2	-0.7	-1.9	-1.5	-1.7	-1.2	-0.3
Diastolic blood pressure, automated reading	1.2	3.7	7.7	-2.1	-2.6	-0.7	-1.6	-1.8	-0.9	-2.8
Commuting to job workplace: Cycle	1.2	1.5	2.9	-1.4	-1.0	-1.4	-0.8	-1.3	-1.7	0.4
Body Mass Index (BMI) (2010)	1.1	1.6	5.5	-1.1	-1.2	-0.1	0.8	0.7	-1.3	-2.3
Hand grip strength (left)	1.1	2.9	6.0	-1.5	-1.9	-1.7	-2.2	-2.5	-0.6	-0.3
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	5.3	-0.3	0.4	0.8	0.6	0.1	-1.4	-2.3
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	7.4	-0.7	-1.2	-2.7	-2.5	-2.6	-0.3	2.0
Exposure to tobacco smoke at home	1.1	1.3	3.2	-0.9	-1.8	0.3	-0.5	0.6	-1.0	-1.8
Peak expiratory flow (PEF)	1.1	2.6	5.9	-1.4	-1.5	-2.4	-1.7	-1.9	-1.2	0.5
Headache pain in last month	1.1	1.9	3.2	-1.8	-1.5	-1.3	-1.3	-1.2	-1.8	-0.7
Mouth/teeth dental problems: Loose teeth	1.1	1.3	5.9	-0.6	-1.3	0.8	0.6	0.0	-0.3	-2.4
Mood swings	1.1	2.0	3.9	2.0	0.7	1.6	1.7	1.5	1.4	0.4
Tinnitus: Yes, now most or all of the time	1.1	1.2	3.2	-0.8	-1.2	-0.7	-1.0	-1.3	-1.8	-0.3
Hearing difficulty/problems: Yes	1.0	1.6	5.2	-1.6	-0.6	-0.7	0.3	-0.4	-1.5	-2.3
Multivitamins +/- minerals	1.0	1.3	5.1	2.3	0.8	0.5	0.4	0.6	1.2	1.2
Chronic bronchitis/emphysema (father)	1.0	1.1	2.4	1.4	-0.8	0.8	1.5	0.6	0.3	1.3
Alcohol usually taken with meals	1.0	1.6	3.3	-0.9	1.8	1.6	0.8	1.1	0.8	-1.5
Had other major operations	1.0	1.2	3.5	-0.7	-1.9	0.7	-0.6	0.3	-0.5	-1.8
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	6.3	0.2	0.9	1.3	0.5	0.4	-0.1	-2.5
Worrier / anxious feelings	1.0	1.9	4.7	-0.1	-1.6	-1.0	-1.2	-2.2	1.2	1.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.3	-0.5	0.6	1.2	1.3	0.8	-0.6	-2.1
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.3	-1.2	-1.5	1.0	0.2	-0.0	-0.5	-1.8
Medication: Seretide 50 evohaler	1.0	1.1	3.6	-0.9	-0.2	-1.1	-1.0	-1.9	-1.2	0.2
Arm fat percentage (left)	1.0	4.0	17.2	-1.2	-0.4	1.5	1.7	1.8	-0.7	-4.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.6	-1.6	-0.0	0.2	0.6	0.9	-1.6	-1.5
Medication: Aspirin	1.0	1.3	3.7	-0.3	1.2	1.0	0.6	1.9	-0.4	-1.4
Mother’s age at death	1.0	1.2	3.6	1.1	1.1	0.9	0.4	0.2	1.2	1.9
Pain experienced in last month	1.0	1.6	3.4	1.7	1.2	0.9	0.5	0.9	1.8	1.4
Crohns Disease (2017)	0.9	2.0	3.8	1.8	1.3	0.8	1.9	1.3	0.6	1.6
Cardiovascular Disease	0.9	3.0	5.6	-2.2	-1.0	-1.1	-0.5	-1.5	-2.4	-2.4
Waist circumference	0.9	3.4	17.2	-1.6	-0.9	1.2	0.7	1.0	-0.5	-4.1
Heart attack	0.9	1.1	4.1	0.1	1.1	1.0	1.1	2.0	-0.2	-0.1
Alcohol intake versus 10 years previously	0.9	1.3	3.1	-1.2	0.6	-0.6	1.1	0.5	-1.8	-1.6
Number of live births	0.9	1.3	3.1	-1.8	-0.1	-0.8	-1.2	-0.3	-1.2	-1.4
Leg fat percentage (right)	0.9	3.4	10.4	-0.5	-0.8	2.0	2.0	2.1	0.4	-3.2
Qualifications: College or University degree	0.9	2.9	7.4	-1.4	0.1	-2.7	-2.3	-2.0	-0.9	1.1
Medication: Blood pressure	0.9	1.5	4.5	-1.6	-0.6	0.0	0.4	0.5	-1.7	-2.1
Illnesses of father: Heart disease	0.9	1.2	3.0	-1.4	-0.8	-1.7	-1.4	-0.3	-0.6	0.6
Qualifications: nursing, teaching	0.9	1.4	4.2	-0.6	-0.3	-1.5	-2.1	-1.2	0.1	1.1
Commuting to job workplace: Walk	0.9	1.0	3.4	0.2	-1.8	1.3	0.2	0.4	-0.1	-1.2
Medication for cholesterol	0.9	1.4	3.0	1.6	0.3	0.8	1.7	1.4	0.8	0.8
Guilty feelings	0.9	1.4	5.3	0.5	-0.5	-0.4	-0.7	-1.3	1.4	2.3
High cholesterol (Self-reported)	0.9	1.7	5.6	0.2	-0.6	2.1	1.0	0.5	0.0	-2.4
Ever depressed for a whole week	0.9	1.1	4.0	2.0	1.5	0.7	0.8	0.5	0.3	0.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.5	1.0	1.6	1.2	0.9	1.2	0.5	-0.3
Depressed Affect (Nagel 2018)	0.8	1.7	3.1	1.4	1.0	1.4	1.7	1.7	0.7	0.2
Alzheimer’s Disease (in mother)	0.8	1.0	4.0	-1.0	-1.1	-0.6	-0.4	-0.5	-0.5	-2.0
Major Depression (MDD)	0.8	1.0	3.7	0.3	1.9	0.2	0.5	0.6	-1.5	0.4
Crohns Disease (2012)	0.8	1.3	2.1	1.4	0.5	1.0	1.0	1.4	0.9	1.5
Blood Platelet Count	0.8	9.2	18.8	-2.5	-2.2	-2.5	-1.3	-3.2	-4.3	-4.0
Sensitivity / hurt feelings	0.8	1.3	4.0	0.7	1.5	0.3	-0.2	0.5	1.5	2.0
Medication: Metformin	0.8	1.1	2.8	-0.4	1.1	1.7	0.3	1.4	-0.2	-1.3
Nervous feelings	0.8	1.4	5.0	0.9	1.3	0.1	0.5	0.2	1.5	2.2
Arm fat percentage (right)	0.8	3.3	14.5	-1.2	-0.4	1.5	1.4	1.7	-0.6	-3.8
Hip circumference	0.8	3.3	17.9	-1.2	-0.8	1.0	0.7	1.0	-0.8	-4.2
Neck or shoulder pain in last month	0.8	1.2	4.4	1.2	0.4	0.9	2.1	1.3	-0.3	0.2
Leg fat mass (right)	0.8	3.0	12.9	-1.1	-1.2	1.3	1.2	1.4	-0.3	-3.6
Medication: Aspirin	0.8	1.0	3.4	-0.1	1.1	0.9	0.6	1.9	-0.5	-1.1
Medication: Gliclazide	0.8	0.9	2.5	-0.4	0.1	1.6	-0.1	1.2	-0.0	-1.4
Arm fat mass (left)	0.8	3.2	15.7	-1.6	-0.9	1.2	0.7	1.2	-0.6	-4.0
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.8	-0.4	-1.3	1.2	0.7	1.0	1.1	-0.8
Age started oral contraceptive pill	0.8	1.0	2.0	0.9	1.4	0.9	1.4	-0.1	1.4	-0.1
Unable to work because of sickness or disability	0.8	1.1	2.9	1.7	0.8	1.3	1.1	0.9	0.6	0.2
Reaction Time	0.7	1.4	3.1	1.3	0.4	1.8	1.1	0.9	1.4	-0.9
Age at First Birth	0.7	1.0	2.4	1.0	1.0	-0.9	1.0	-0.3	-0.7	1.6
Systolic Blood Pressure	0.7	3.4	7.1	-2.3	-0.7	-1.9	-2.2	-2.7	-1.3	-0.8
Diabetes (father)	0.7	0.9	3.9	0.7	2.0	0.6	0.5	0.8	-0.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.6	0.2	-0.3	-0.3	-0.6	-1.1	1.6	1.6
Body mass index (BMI)	0.7	3.1	14.7	-1.4	-1.0	0.9	0.9	1.2	-0.9	-3.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.7	1.2	1.6	0.0	0.5	0.9	0.4	0.6
Impedance of arm (right)	0.7	3.1	7.6	2.4	1.8	1.0	0.8	1.0	1.7	2.8
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.3	-0.8	-0.2	-1.8	-2.3	-1.4	-0.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	-0.5	-1.3	-0.7	-1.3	-0.9	-0.9	-0.3
Asthma	0.7	1.4	5.9	-1.0	-0.6	0.7	0.5	0.2	-1.2	-2.4
Arm fat mass (right)	0.7	3.0	14.3	-1.6	-0.9	0.8	0.6	1.0	-0.8	-3.8
High blood pressure (siblings)	0.7	1.0	2.4	-0.7	-0.6	-0.9	0.9	-0.7	-1.4	-1.5
Body fat percentage	0.7	2.6	9.5	-0.8	-0.5	1.5	1.6	1.8	-0.2	-3.1
Eye problems/disorders: None of the above	0.7	0.8	3.7	0.6	0.2	-0.3	-0.4	0.2	1.0	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.1	0.7	0.2	1.8	0.8	0.9	0.6	-0.4
Supplements: Vitamin C	0.7	0.9	2.5	0.8	-0.3	1.1	1.0	0.6	1.6	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	0.9	1.3	0.1	0.8	1.0	0.5	0.9
Diabetes diagnosed by doctor	0.7	1.1	4.0	-0.8	0.3	1.0	0.0	0.0	-1.4	-2.0
Leg fat percentage (left)	0.7	2.5	8.5	-0.8	-1.1	1.5	1.5	1.7	0.1	-2.9
Number of operations (self-reported)	0.7	1.0	4.3	-0.6	-0.9	0.7	-0.8	0.2	-0.5	-2.1
Irritability	0.7	1.2	4.3	-0.3	-1.4	-0.5	-2.1	-1.0	0.7	0.6
Basal cell carcinoma (self-reported)	0.7	0.8	3.5	0.4	0.2	-0.4	-0.8	-0.5	1.0	1.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.3	-0.1	1.0	0.9	0.9	1.8	-0.4	-0.2
Leg fat mass (left)	0.7	2.7	11.9	-1.2	-1.2	1.0	1.0	1.2	-0.4	-3.5
Fasting Glucose	0.6	0.8	1.4	-0.6	-1.1	-0.9	-0.1	-1.2	-1.1	-0.5
Smoking Status	0.6	1.3	8.2	0.0	-2.9	-0.1	-0.1	-0.7	-0.8	-0.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.2	-0.9	0.2	0.8	0.5	-0.1	-1.8	-1.7
Medication: Co-codamol	0.6	0.7	1.6	-0.6	-0.8	-0.8	-1.1	-0.7	-1.3	-0.4
Trunk fat percentage	0.6	2.3	7.4	-0.6	0.0	1.5	1.5	2.0	-0.3	-2.7
Hand grip strength (right)	0.6	1.5	2.7	-1.6	-0.5	-1.6	-1.4	-1.6	-0.8	-0.3
Medication: Levothyroxine sodium	0.6	1.0	2.0	0.6	1.4	0.1	-0.3	0.6	1.4	1.4
Impedance of leg (left)	0.6	3.0	15.7	1.2	-0.3	-0.8	-0.8	-0.9	1.1	4.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.5	-0.3	-1.6	-1.0	-0.6	-1.5	-0.6	0.5
Qualifications: None of the above	0.6	1.3	2.6	-0.2	-0.7	1.6	1.5	1.0	-0.3	-1.5
Financial difficulties in last 2 years	0.6	0.8	4.2	-0.1	-0.2	0.9	-0.2	0.8	-0.4	-2.0
Father’s age at death	0.6	0.8	3.0	0.1	1.7	0.2	1.0	0.8	-0.5	-1.0
Depression (self-reported)	0.6	0.7	2.6	1.0	0.7	-0.7	-0.0	-0.3	0.3	1.6
Illnesses of mother	0.6	0.7	2.0	-0.1	1.0	0.8	0.0	1.4	0.1	-1.1
Gout (self-reported)	0.6	0.8	1.7	0.7	0.6	-0.8	-1.0	-1.0	-0.2	1.3
Wheeze or whistling in the chest in last year	0.6	1.2	2.1	0.3	-1.0	1.4	1.3	1.3	0.2	-1.2
Whole body fat mass	0.6	2.4	10.8	-1.1	-0.9	1.0	1.0	1.2	-0.3	-3.3
Alcohol intake frequency.	0.6	1.4	3.6	-0.5	1.5	0.3	1.1	1.0	-1.9	-1.2
Smoking status: Previous	0.6	0.9	3.3	0.1	-1.8	0.6	1.0	-0.1	-0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.7	1.6	0.8	0.7	1.2	-0.2	1.1	1.6
Long-standing illness, disability or infirmity	0.6	1.0	2.1	0.4	1.0	0.7	1.4	1.1	-0.8	-1.2
Friendships satisfaction	0.6	0.8	2.9	0.9	0.0	0.9	-0.1	0.5	1.7	1.0
Asthma (self-reported)	0.6	1.3	5.4	-0.9	-0.6	0.6	0.4	0.1	-1.2	-2.3
Number of self-reported non-cancer illnesses	0.6	1.0	3.7	0.1	0.3	1.0	0.6	1.3	-0.6	-1.9
Commuting to job workplace: Public transport	0.6	0.7	2.5	-1.0	-0.6	-0.3	-0.7	-1.6	-0.1	-0.6
Average weekly beer plus cider intake	0.6	0.9	1.7	0.4	-0.6	-1.1	-1.1	-1.2	-0.1	1.3
Bipolar Disorder (2018)	0.5	0.8	4.8	-0.5	2.2	-0.1	0.4	-0.2	0.2	-0.8
Alzheimer’s Disease (in father)	0.5	0.5	2.0	-0.5	-0.2	-1.4	-0.9	-0.5	-0.2	0.5
Alzheimer’s Disease (including proxy)	0.5	0.8	2.0	-0.9	-1.0	-1.4	-0.9	-0.6	-0.3	-0.3
Irritable Bowel Disease (IBD)	0.5	1.1	2.2	1.3	0.9	0.6	1.1	1.5	0.5	1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.8	-1.3	-0.6	-1.0	-1.3	-1.3	-0.3	-1.1
Mean Putamen Volume	0.5	0.6	1.4	-0.6	0.7	-0.5	-0.7	-1.2	-0.7	-0.6
HbA1C	0.5	0.6	2.5	-0.4	-0.6	-0.2	-0.6	0.3	-0.7	-1.6
BMI	0.5	2.7	12.6	-1.9	-0.6	0.4	0.1	0.3	-1.3	-3.5
Hypothyroidism (self reported)	0.5	1.1	4.2	0.8	1.3	-0.5	0.1	0.1	0.8	2.1
Lung FEV1/FVC ratio	0.5	2.5	3.6	1.7	1.7	0.6	1.3	1.7	1.9	1.8
Vitamin and mineral supplements	0.5	0.7	2.0	-1.4	-0.5	-1.0	-0.4	-0.7	-1.1	-0.2
Impedance of leg (right)	0.5	2.2	10.9	1.4	-0.1	-0.3	-0.3	-0.6	1.4	3.3
Age when periods started (menarche)	0.5	1.1	2.6	-0.4	-1.6	-0.6	-0.6	-1.3	1.4	0.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	1.2	0.7	0.7	1.0	0.6	0.3	0.6
High blood pressure	0.5	1.3	2.8	-1.4	-1.3	-0.3	-0.2	-0.8	-1.3	-1.7
Trunk fat mass	0.5	2.0	8.8	-1.0	-0.6	1.1	0.9	1.3	-0.2	-3.0
Allergy	0.5	1.1	2.6	-0.9	-0.7	-1.6	-1.1	-1.0	-1.0	0.8
Noisy workplace	0.5	0.6	2.9	0.0	-0.8	-0.0	-1.7	-0.3	0.2	-0.8
Mouth/teeth dental problems: Dentures	0.5	0.9	3.4	-0.0	-1.9	0.8	0.2	1.2	0.1	-1.0
Medication: Lansoprazole	0.5	0.5	1.6	-0.0	1.3	-1.0	0.3	0.4	-0.7	0.5
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.0	0.8	1.4	0.2	0.6	0.9	1.1	1.2
Emphysema/chronic bronchitis	0.5	0.5	1.0	-0.6	-0.9	0.4	-1.0	-0.8	0.8	-0.2
Migraine (self-reported)	0.5	0.6	2.1	0.8	0.5	-0.3	0.3	1.0	-0.2	1.4
Knee pain experienced in last month	0.5	0.8	2.8	0.1	-0.1	0.9	1.3	0.2	-0.5	-1.7
Hypertension (Self-reported)	0.5	1.3	3.9	-1.4	-1.0	-0.3	-0.2	-0.7	-1.3	-2.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	3.3	-1.8	-1.2	0.2	-0.4	-0.6	-0.3	-0.8
Mineral and other dietary supplements	0.5	0.6	1.5	-1.0	-1.2	-0.9	-0.8	-0.7	-0.4	-0.0
Myopia	0.5	0.7	2.1	0.8	1.5	-0.7	0.8	0.3	-0.7	0.7
Neuroticism (Nagel 2018)	0.4	1.0	2.5	0.9	1.0	0.4	0.5	0.5	1.5	1.6
Bipolar Disorder (2011)	0.4	0.4	1.1	0.9	1.1	0.1	0.7	0.0	0.2	0.5
Primary Biliary Cirrhosis	0.4	0.6	1.4	-0.5	0.7	0.7	0.3	1.1	-0.1	-1.2
Respiratory disease	0.4	0.9	3.4	-1.2	-0.4	0.2	-0.2	0.5	-0.9	-1.9
Lung FVC	0.4	1.8	4.0	-0.1	-1.0	-1.1	-2.0	-1.8	0.2	1.7
Chronotype (morning person)	0.4	0.9	1.9	1.1	1.3	1.4	0.5	0.8	0.3	0.7
Angina	0.4	0.5	2.1	-0.2	-0.2	0.3	0.8	1.5	-0.8	-0.2
Fed-up feelings	0.4	0.8	2.7	1.3	-0.6	-0.2	0.1	0.2	0.9	1.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	-1.0	-0.5	-0.7	-0.9	-0.4	-0.3	-0.2
Past tobacco smoking	0.4	0.8	3.8	0.1	1.9	0.2	-0.2	0.7	0.8	0.8
Diabetes (self-reported)	0.4	0.6	1.9	-0.3	-0.2	0.9	-0.2	-0.1	-1.0	-1.4
Illnesses of siblings	0.4	0.6	2.3	-0.2	-0.2	0.4	-1.5	-0.4	1.2	0.3
Weight	0.4	2.1	10.8	-1.3	-1.2	0.8	0.2	0.5	-0.4	-3.3
Trunk fat-free mass	0.4	2.3	3.7	-1.9	-1.7	-1.0	-1.5	-1.5	-0.8	-1.9
Impedance of arm (left)	0.4	1.9	3.8	1.9	1.5	1.0	0.8	0.7	1.2	1.8
Trunk predicted mass	0.4	2.3	3.7	-1.9	-1.7	-0.9	-1.5	-1.4	-0.9	-1.9
Birth weight of first child	0.4	0.6	1.5	0.8	0.4	1.2	0.3	0.7	1.2	-0.5
Arm fat-free mass (right)	0.4	2.1	5.1	-1.9	-1.6	-0.7	-1.0	-1.0	-1.1	-2.3
Worry too long after embarrassment	0.4	0.8	1.6	0.0	-0.5	-0.4	-1.2	-0.9	1.1	1.2
Angina (self-reported)	0.4	0.5	1.8	-0.4	-0.0	0.3	0.9	1.4	-0.8	-0.4
Arm predicted mass (right)	0.4	2.1	4.1	-2.0	-1.5	-1.1	-1.1	-1.1	-1.1	-1.8
Suffer from ‘nerves’	0.4	0.6	1.8	-0.0	0.6	-0.8	0.8	-0.7	0.0	1.4
Loneliness, isolation	0.4	0.5	1.1	1.0	0.1	0.4	0.9	0.0	1.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.8	-0.4	-0.7	-0.6	-1.3	-0.2	-0.4	0.3
Osteoarthritis (self-reported)	0.4	0.6	1.2	0.6	-0.9	0.8	-0.8	0.0	1.1	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.8	-0.8	-0.0	-0.2	-0.1	-0.7	-0.4	-1.3
Miserableness	0.4	0.8	2.2	-0.7	-0.3	-1.5	-0.8	-1.3	-0.3	-0.2
Hearing aid user	0.4	0.5	2.1	-0.7	-1.5	0.3	-0.4	-0.0	-0.5	-0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	1.3	0.4	1.1	0.3	0.6	0.6	-0.2
Arm fat-free mass (left)	0.4	2.0	5.1	-1.8	-1.6	-0.6	-1.0	-0.8	-0.9	-2.2
Risk taking	0.4	0.6	2.1	0.8	0.4	0.5	0.9	1.4	-0.5	0.4
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.5	1.2	1.1	-0.0	-0.5	0.2	1.4	1.9
Impedance of whole body	0.4	2.3	9.6	1.9	1.0	0.1	0.2	-0.1	1.3	3.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.9	-0.7	-0.7	-1.0	-1.2	-1.4	0.4	-0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.8	0.1	-0.6	-0.0	-1.3	-0.6	0.1	0.3
Breast Cancer	0.3	0.7	1.9	-0.7	-0.5	-0.5	-0.9	-0.7	-1.4	-0.9
Prostate Cancer	0.3	0.5	1.2	-1.1	0.2	-1.0	-0.7	-0.6	-0.4	0.4
Coronary Artery Disease (CAD)	0.3	0.4	1.5	-0.1	1.2	0.9	0.1	0.3	0.4	-0.2
Lupus	0.3	0.4	1.1	0.3	0.4	-0.2	0.6	1.1	-0.8	-0.4
Blood Red Count	0.3	2.6	13.2	-1.6	-0.2	1.4	-0.3	0.4	-0.6	-3.6
Heel T-Score	0.3	2.0	4.7	-1.6	-0.4	-1.0	-0.9	-1.1	-2.2	-2.0
Medication for hormone replacement therapy	0.3	0.3	0.6	0.4	0.5	0.8	0.5	0.4	-0.3	-0.7
Supplements: Zinc	0.3	0.3	0.7	0.8	-0.9	0.4	0.4	0.0	0.6	0.5
Diabetes (mother)	0.3	0.4	1.4	-0.3	-0.3	0.8	0.1	-0.1	-0.6	-1.2
Leg fat-free mass (left)	0.3	1.7	7.9	-1.3	-0.9	-0.2	-0.4	-0.3	-1.1	-2.8
Current tobacco smoking	0.3	0.5	1.9	0.8	0.1	0.5	-0.1	1.4	0.9	0.5
Leg predicted mass (left)	0.3	1.7	7.8	-1.3	-0.9	-0.2	-0.4	-0.3	-1.0	-2.8
Number of incorrect matches in round	0.3	0.5	1.6	-0.4	1.3	-0.1	0.5	0.3	0.4	1.0
Hair/balding pattern: Pattern 2	0.3	0.3	0.9	0.8	0.1	0.0	0.4	0.9	0.5	0.7
Fluid intelligence score	0.3	0.6	1.4	0.3	1.0	0.9	0.8	0.3	1.2	-0.3
Neuroticism score	0.3	0.7	2.2	0.6	0.1	0.4	-0.1	-0.1	1.5	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.3	0.3	0.3	0.8	0.0	0.4	1.1	0.0
Tense / ‘highly strung’	0.3	0.6	2.2	0.6	0.4	0.2	0.3	-0.3	1.5	1.1
Comparative body size at age 10	0.3	0.7	3.8	0.7	-0.2	-0.7	0.3	0.3	0.2	2.0
Number of full brothers	0.3	0.3	1.1	-0.4	-1.0	0.6	-0.3	-0.2	0.4	-0.5
Shortness of breath walking on level ground	0.3	0.3	1.5	-0.5	-0.5	0.4	-0.4	-0.2	-0.0	-1.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.6	-0.4	0.2	-1.3	-0.4	-0.2	-0.7	-0.0
Illnesses of siblings: Diabetes	0.3	0.4	1.9	-0.2	-0.0	0.1	0.9	-0.1	-1.4	-0.2
Whole body fat-free mass	0.3	2.0	4.8	-1.7	-1.4	-0.8	-1.1	-1.1	-1.1	-2.2
Leg fat-free mass (right)	0.3	1.6	6.0	-1.4	-0.9	-0.5	-0.8	-0.5	-1.2	-2.5
Breast cancer (self-reported)	0.3	0.4	1.4	0.3	-0.8	-0.1	-0.3	-1.2	-0.4	-0.2
Osteoporosis (self-reported)	0.3	0.4	1.2	-0.1	-1.1	0.0	0.3	-0.6	-0.6	-0.9
Whole body water mass	0.3	1.9	5.2	-1.7	-1.3	-0.7	-1.1	-0.9	-1.0	-2.3
Leg predicted mass (right)	0.3	1.5	6.1	-1.3	-0.8	-0.3	-0.7	-0.4	-1.1	-2.5
Wears glasses or contact lenses	0.3	0.3	1.1	-1.0	0.3	-0.2	-0.3	0.2	0.3	-0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.9	-0.4	1.0	0.1	-0.9	0.3	0.5	-0.4
Basal metabolic rate	0.3	1.9	6.4	-1.7	-1.4	-0.4	-0.8	-0.7	-1.0	-2.5
Fractured/broken bones in last 5 years	0.3	0.4	2.2	-0.1	-0.0	0.4	0.4	0.1	0.4	-1.5
Cholesterol lowering medication	0.3	0.4	2.1	-0.4	0.2	0.7	-0.1	0.1	-0.3	-1.4
Supplements: Calcium	0.3	0.4	2.0	-0.3	0.2	-1.4	-0.2	-0.3	-0.5	0.2
Arm predicted mass (left)	0.3	1.4	3.9	-1.6	-1.2	-0.5	-0.8	-0.6	-0.9	-2.0
Bipolar Disorder or Schizophrenia	0.2	0.4	2.8	-0.4	1.7	-0.1	-0.1	-0.2	0.2	-0.0
Worry (Nagel 2018)	0.2	0.5	1.4	-0.2	0.4	-0.5	0.3	-0.9	0.6	1.2
Ulcerative Colitis (UC)	0.2	0.3	1.4	0.4	0.8	0.2	0.2	1.2	0.1	0.4
Blood Eosinophil Count	0.2	1.4	2.7	1.1	0.3	1.7	1.3	1.6	1.0	-0.7
Blood White Count	0.2	1.4	3.9	-1.1	-1.0	-0.8	-0.4	-0.7	-2.0	-1.4
Waist Hip Ratio (WHR)	0.2	0.8	2.9	-0.5	0.1	0.9	0.7	0.8	0.6	-1.7
Severe depression (siblings)	0.2	0.3	0.5	0.7	0.7	0.6	0.2	0.4	0.7	0.1
Townsend deprivation index at recruitment	0.2	0.2	0.7	-0.5	-0.5	-0.6	-0.8	-0.0	-0.1	0.3
Sitting height	0.2	1.2	4.3	1.1	-1.0	0.9	-0.3	-0.3	2.1	0.8
Pain all over the body in last month	0.2	0.3	0.7	-0.8	-0.3	-0.5	0.2	-0.4	-0.7	0.3
Medication: Ramipril	0.2	0.3	1.4	-0.1	1.2	0.0	0.2	-0.0	-0.7	-0.3
Medication: Paracetamol	0.2	0.4	1.6	0.2	0.3	0.4	0.7	0.6	0.4	1.3
Glaucoma (self-reported)	0.2	0.2	0.6	-0.8	0.3	-0.1	-0.1	0.2	-0.2	-0.8
Age at first live birth	0.2	0.3	1.1	0.1	1.0	-0.3	0.3	-0.0	-0.3	0.6
Medication: Allopurinol	0.2	0.2	1.3	0.4	1.1	0.2	-0.1	-0.1	0.1	0.0
Heart disease (mother)	0.2	0.3	0.9	0.7	-0.3	-0.2	-0.0	-0.5	-0.2	0.9
Family relationship satisfaction	0.2	0.3	0.8	0.6	0.4	0.1	-0.9	-0.2	0.5	0.5
Average weekly red wine intake	0.2	0.3	0.8	-0.9	0.7	0.5	-0.5	-0.1	0.1	-0.5
Smoking status: Current	0.2	0.3	0.6	0.7	0.0	0.4	-0.3	0.8	0.8	0.5
Ever taken oral contraceptive pill	0.2	0.2	0.9	-0.1	-0.4	0.5	0.4	-0.1	0.1	-1.0
Eye problems/disorders: Glaucoma	0.2	0.3	0.9	-0.2	0.4	0.4	0.6	0.5	-0.0	-0.9
Medication: Paracetamol	0.2	0.3	0.8	-0.6	-0.9	0.4	0.2	0.1	-0.5	-0.6
Ever smoked	0.2	0.3	1.0	0.2	-1.0	-0.6	-0.6	-0.6	-0.3	0.3
Heart disease (siblings)	0.2	0.3	1.0	-0.7	0.8	0.2	0.0	1.0	-0.0	0.0
Schizophrenia (2018)	0.1	0.1	0.4	-0.2	0.4	0.0	-0.5	-0.1	0.2	0.6
Ulcerative Colitis	0.1	0.2	0.8	-0.4	0.5	0.1	-0.0	0.9	0.2	0.2
Height	0.1	1.1	4.6	-0.7	-1.0	-0.8	-0.9	-2.1	0.6	-0.1
Allergy or Eczema	0.1	0.2	0.8	0.3	0.9	-0.3	-0.1	-0.1	-0.2	-0.6
Neuroticism	0.1	0.2	0.5	-0.1	0.5	0.3	0.7	0.5	0.4	0.7
Hair Pigment	0.1	1.8	3.4	-1.8	-0.5	-1.8	-1.6	-1.7	-0.8	-0.2
Tanning	0.1	0.8	1.8	0.4	-0.1	0.1	1.1	0.7	-1.3	-1.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.6	-0.1	0.4	0.4	0.6	0.8	-0.0	0.1
Systolic blood pressure, automated reading	0.1	0.3	1.1	-0.1	0.4	0.8	0.1	-0.2	0.4	-1.0
Pack years adult smoking proportion	0.1	0.2	0.6	0.3	-0.6	-0.1	-0.3	0.2	-0.0	0.8
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.4	0.6	0.2	-0.2	-0.1	0.7	-0.3
Stomach or abdominal pain in last month	0.1	0.2	0.8	0.1	0.5	0.3	-0.0	0.9	0.1	-0.0
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.7	0.0	-0.6	0.6	-0.1	-0.2	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	0.5	-0.5	0.1	0.7	0.3	-0.2	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.8	0.3	0.1	-0.5	-0.9	-0.2	0.1	0.3
Standing height	0.1	1.0	2.8	-0.0	-0.8	-0.4	-1.5	-1.7	0.9	0.8
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	-0.4	0.2	0.9	-0.5	-0.2	0.5	-0.8
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.2	-0.5	-0.3	0.3	0.4	-0.0	0.4
Medication: Ibuprofen	0.1	0.2	0.8	-0.0	0.4	0.4	0.1	0.3	0.9	-0.1
Comparative height size at age 10	0.1	0.8	2.8	1.1	-0.1	1.7	0.7	0.6	0.5	-0.5
Overall health rating	0.1	0.1	0.5	0.1	-0.2	0.4	-0.3	0.3	0.7	0.3
Age at last live birth	0.1	0.2	0.5	-0.2	0.5	-0.5	0.4	-0.1	-0.7	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	0.7	0.1	0.0	0.0	0.3	0.6	0.2
Eye problems/disorders: Cataract	0.1	0.1	0.4	0.2	-0.3	0.1	0.1	-0.4	-0.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.7	0.8	0.6	0.0	0.1	-0.0	0.4	0.7
Medication: Bendroflumethiazide	0.1	0.2	0.6	0.3	-0.7	-0.6	0.1	-0.5	-0.1	-0.4
Pack years of smoking	0.1	0.2	0.5	0.3	-0.7	0.3	-0.3	0.4	0.2	0.6
Schizophrenia (2014)	0.0	0.1	0.4	-0.0	0.6	0.0	-0.4	-0.1	0.3	0.3
Average weekly spirits intake	0.0	0.1	0.1	0.1	-0.2	0.3	-0.2	0.3	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.4	0.4	-0.1	-0.3	0.3	-0.0	0.0	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.3	-0.0	-0.1	0.2	0.2	-0.4	-0.0

Hub : Genes

HACL1

Models

Trait associations