Hub : Genes

EAF1-AS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.159	0.062	4.5e-03	-0.002	NA	0.010	NA	0.007	4.7e-01	NA	5.4e-02	NA	9.1e-02
2	GTEx	Brain Cerebellar Hemisphere	0.446	0.088	6.7e-09	0.515	NA	0.478	NA	0.494	2.2e-15	NA	5.4e-14	NA	1.4e-14
3	GTEx	Brain Cerebellum	0.425	0.097	1.0e-08	0.427	NA	0.287	NA	0.400	6.1e-14	NA	4.0e-09	NA	6.3e-13
4	GTEx	Cells Transformed fibroblasts	0.058	0.030	8.4e-03	0.044	NA	0.026	NA	0.017	3.1e-04	NA	4.4e-03	NA	1.7e-02
5	GTEx	Testis	0.104	0.046	7.1e-03	0.056	NA	0.029	NA	0.048	1.7e-03	NA	1.9e-02	NA	3.5e-03
6	GTEx	Thyroid	0.098	0.045	5.5e-03	-0.004	NA	-0.001	NA	-0.003	9.9e-01	NA	4.3e-01	NA	8.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.7	1.9	1.4	0.1	0.4	1.0	1.1	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.6	0.4	0.6	-0.2	-0.0	-0.8
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	-0.0	-0.5	-0.7	0.3	0.5	-0.4
Depression (Nagel 2018)	1.3	2.0	3.7	-1.1	-1.9	-1.9	-1.3	-1.1	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.3	0.1	-0.3	-0.1	1.2	1.5	-0.2
Neuroticism (Nagel 2018)	0.2	0.5	1.5	-0.5	-0.5	-0.5	-0.8	-1.2	-0.5
Schizophrenia (2018)	0.3	0.6	1.2	-0.3	0.3	0.5	-1.1	-0.9	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.6	1.6	-1.3	-0.9	-0.7	0.2	-0.2	-0.7
Worry (Nagel 2018)	1.7	3.5	8.2	-2.5	0.7	0.9	-1.5	-2.9	-1.8
Alzheimer’s Disease (in mother)	1.5	1.8	5.7	-0.5	0.5	0.6	2.4	1.6	-1.3
Alzheimer’s Disease (in father)	0.8	0.8	3.0	1.0	-0.7	-0.6	-0.0	0.4	1.7
Alzheimer’s Disease (including proxy)	0.2	0.2	1.2	-0.1	0.0	0.2	1.1	0.3	0.1
Crohns Disease (2017)	0.6	1.3	2.2	1.5	-1.4	-1.3	-1.3	-0.6	0.2
Irritable Bowel Disease (IBD)	0.3	0.7	2.0	1.4	-0.7	-0.8	-0.7	0.1	0.8
Ulcerative Colitis (UC)	0.1	0.1	0.4	0.6	0.3	0.1	-0.2	0.3	0.4
Major Depression (MDD)	1.6	1.9	9.3	0.1	0.1	0.1	-1.1	-0.9	-3.0
Reaction Time	0.8	1.5	3.9	-2.0	-0.8	-0.7	1.5	1.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.9	-0.4	1.0	1.0	1.1	1.4	-0.3
Breast Cancer	0.2	0.6	2.2	-1.0	0.2	0.1	0.1	0.2	-1.5
Ovarian Cancer	0.1	0.1	0.3	-0.3	0.5	0.4	0.3	-0.1	-0.5
Prostate Cancer	1.2	1.7	3.2	-1.0	1.3	1.2	-1.1	-1.8	-1.2
Age at First Birth	2.3	3.3	8.2	1.5	-2.9	-2.6	-1.4	-0.5	-0.4
Bipolar Disorder (2011)	1.8	1.7	6.0	2.5	-1.2	-1.1	-0.6	0.3	1.1
Body Mass Index (BMI) (2010)	1.2	1.7	3.6	0.8	1.1	1.1	1.8	1.9	0.6
Coronary Artery Disease (CAD)	1.0	1.2	2.6	-1.0	1.6	1.4	0.7	-0.2	-0.9
Crohns Disease (2012)	0.6	0.9	1.5	1.2	-1.2	-1.1	-0.9	-0.5	0.6
Mean Putamen Volume	0.2	0.2	0.4	0.4	0.2	0.3	0.4	0.5	0.7
Fasting Glucose	0.3	0.4	1.3	-0.3	0.3	0.5	-0.5	-0.7	-1.1
HbA1C	1.7	1.9	5.5	-1.1	0.0	0.2	2.3	2.2	-0.0
HDL Cholesterol	1.3	2.1	4.5	0.1	-1.4	-1.1	-2.1	-2.1	0.8
LDL Cholesterol	1.4	2.3	3.7	-0.9	1.9	1.9	1.9	1.4	0.0
Lupus	0.3	0.5	2.3	-0.3	0.1	-0.3	1.5	0.3	-0.4
Neuroticism (2016)	0.2	0.3	0.7	-0.2	-0.2	-0.4	-0.6	-0.8	0.7
Primary Biliary Cirrhosis	1.1	1.6	2.8	-0.2	1.5	1.5	1.7	1.5	0.1
Rheumatoid Arthritis	1.9	2.6	3.8	-1.5	1.8	1.8	-1.3	-1.9	-1.2
Schizophrenia (2014)	0.0	0.1	0.2	0.5	-0.2	0.0	-0.4	-0.1	-0.2
Triglycerides	0.9	1.5	3.3	-0.4	1.2	1.2	1.1	1.2	-1.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.6	-0.0	0.7	0.4	-0.2	0.0	-1.6
Ulcerative Colitis	0.4	0.6	1.3	1.1	0.8	0.6	0.0	0.5	0.9
Blood Eosinophil Count	0.1	1.1	4.5	-2.1	0.5	0.3	1.1	0.3	-0.5
Blood Platelet Count	0.2	1.8	5.7	-1.2	0.8	0.9	1.4	2.4	-0.0
Blood Red Count	0.9	9.1	13.9	-0.1	3.7	3.6	3.5	3.0	2.4
Blood White Count	0.1	0.6	1.6	-0.0	1.3	1.2	-0.3	-0.6	-0.2
Heel T-Score	0.2	1.4	3.6	-1.9	1.4	1.2	1.1	0.8	0.0
BMI	1.3	7.4	18.4	-0.6	4.3	4.2	2.5	1.2	-0.4
Height	0.1	1.8	8.2	2.9	-0.9	-0.8	-0.0	1.1	-0.2
Waist Hip Ratio (WHR)	1.0	4.4	9.7	-3.1	2.2	2.2	1.6	-0.6	-1.9
Systolic Blood Pressure	0.2	1.0	2.4	-0.1	1.0	1.2	1.0	0.1	1.5
Smoking Status	0.0	0.1	0.2	-0.3	-0.0	-0.2	-0.3	-0.5	0.2
Allergy or Eczema	0.2	0.5	2.1	0.5	-0.4	-0.4	0.6	1.4	-0.2
Cardiovascular Disease	0.6	2.0	5.0	-0.5	2.2	2.2	1.4	0.3	-0.1
Hypothyroidism (self reported)	0.7	1.5	2.2	0.9	-1.5	-1.5	-1.0	-1.1	1.3
Respiratory disease	0.9	2.1	3.1	0.3	1.7	1.7	1.6	1.8	-0.9
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.1	-0.4	2.2	2.2	0.8	-0.1	-1.5
Lung FEV1/FVC ratio	0.4	1.9	5.2	2.3	-1.5	-1.6	-1.1	-0.7	0.2
Lung FVC	0.3	1.7	2.2	-0.5	-1.4	-1.4	-1.5	-1.3	1.4
Neuroticism	0.2	0.5	0.8	-0.9	0.6	0.7	-0.6	-0.7	-0.5
Chronotype (morning person)	0.1	0.2	0.5	0.4	-0.5	-0.5	-0.7	-0.3	-0.3
Hair Pigment	0.1	1.5	7.3	-0.4	0.8	0.9	0.4	0.2	2.7
Tanning	0.1	1.7	4.1	-2.0	0.4	0.3	1.2	0.8	-1.9
Hand grip strength (left)	0.2	0.4	1.9	0.6	-0.1	-0.2	0.1	0.3	1.4
Number of treatments/medications taken	1.7	3.1	6.4	1.1	1.2	1.3	2.3	2.5	1.6
Average weekly spirits intake	0.4	0.5	1.3	1.1	1.0	0.8	0.0	0.4	-0.1
Sensitivity / hurt feelings	0.4	0.7	1.7	1.3	-0.8	-0.6	-0.8	-0.8	-0.6
Frequency of depressed mood in last 2 weeks	3.2	4.4	10.4	-0.8	-3.2	-3.1	-1.3	-1.3	-1.6
Hearing difficulty/problems: Yes	1.9	2.8	5.6	-1.0	2.3	2.4	1.0	0.2	-1.9
Relative age of first facial hair	1.7	3.5	5.8	2.4	-1.9	-1.9	-2.1	-0.9	1.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	0.5	0.5	0.6	-0.2	-0.2	-0.1
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.4	1.2	1.4	1.3	1.2	1.6	-0.3
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	0.5	-0.5	-0.7	1.2	1.3	0.8
Systolic blood pressure, automated reading	0.3	0.8	1.6	0.4	0.5	0.6	1.3	1.0	1.3
Eye problems/disorders: Diabetes related eye disease	2.4	2.7	9.2	0.3	0.7	0.6	3.0	2.3	-0.6
Angina	0.8	1.0	2.5	-0.7	1.5	1.6	-0.2	-0.8	-0.4
Medication for hormone replacement therapy	0.2	0.3	0.7	0.4	-0.1	-0.2	0.8	0.9	0.3
Vitamin and mineral supplements	0.6	0.8	2.0	-0.3	1.4	1.4	-0.1	-0.6	0.2
Supplements: Zinc	0.3	0.3	0.8	-0.3	-0.4	-0.5	-0.9	-0.7	-0.4
Medication: Co-codamol	0.2	0.2	0.9	-0.1	0.1	0.1	-0.4	-0.4	-0.9
Medication: Metformin	1.5	2.0	4.0	1.6	2.0	1.9	0.4	1.2	0.6
Diabetes (father)	0.8	1.0	3.3	1.8	-1.1	-1.1	-0.5	-0.1	-0.3
Diabetes (mother)	2.9	3.6	8.3	-2.9	1.9	1.8	0.3	-1.0	-2.4
Severe depression (siblings)	0.4	0.4	1.6	1.2	-0.7	-0.7	0.1	0.3	0.2
Pack years adult smoking proportion	0.2	0.3	0.6	0.6	-0.6	-0.7	-0.3	-0.8	0.4
Impedance of leg (right)	1.1	5.1	10.4	-0.6	-2.6	-2.5	-3.2	-2.5	0.7
Leg fat-free mass (left)	0.7	3.6	6.1	1.3	2.1	2.0	2.5	2.1	-1.3
Trunk fat percentage	1.3	5.4	13.0	-0.2	3.6	3.5	1.5	0.8	-2.0
Hand grip strength (right)	0.2	0.5	1.8	0.4	0.7	0.6	0.2	0.3	1.3
Townsend deprivation index at recruitment	2.2	3.0	6.3	-2.5	0.8	0.7	-0.9	-1.9	-2.5
Current tobacco smoking	1.5	2.4	8.9	2.1	-0.2	-0.4	0.2	1.1	3.0
Average weekly fortified wine intake	0.4	0.5	1.3	0.5	0.6	0.6	0.8	1.1	0.0
Maternal smoking around birth	0.7	1.0	3.3	-0.5	0.6	0.4	1.8	1.4	-0.5
Fed-up feelings	1.1	2.0	5.9	0.4	-2.3	-2.4	-0.5	-0.4	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.1	-1.7	-1.1	-0.9	-1.3	-1.8	-1.4
Relative age voice broke	1.2	1.8	3.7	1.9	0.8	1.0	0.8	1.5	1.6
Taking other prescription medications	2.4	3.7	7.4	0.5	2.7	2.7	2.0	1.9	-0.1
Age when periods started (menarche)	0.3	0.7	1.4	-1.1	-0.4	-0.2	-1.2	-1.1	0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.9	0.6	-0.9	-0.9	-0.2	-0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	-0.3	-0.7	-0.8	-0.4	-0.4	0.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.7	-1.5	1.6	1.4	0.1	-0.9	-0.1
Qualifications: CSEs or equivalent	0.3	0.4	0.6	0.8	-0.7	-0.6	-0.6	-0.4	0.4
Serious illness, injury or assault to yourself	1.7	2.1	3.5	0.0	1.4	1.4	1.9	1.9	-1.3
High blood pressure	0.5	1.3	3.3	-0.5	1.8	1.8	0.9	-0.0	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	1.0	0.1	0.0	-0.0	0.7	1.0	-0.0
Multivitamins +/- minerals	2.8	3.5	9.6	1.2	-3.1	-3.1	-0.6	0.1	-0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.1	-0.1	-0.0	0.4	0.5	0.1
Supplements: Glucosamine	1.5	1.9	3.0	1.6	-1.7	-1.7	0.8	1.3	-0.9
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	5.2	2.2	-2.3	-2.2	-0.9	0.3	0.5
Medication: Atenolol	3.8	4.7	11.0	-1.8	3.3	3.3	1.8	0.3	0.4
Medication: Levothyroxine sodium	0.3	0.6	1.2	0.8	-0.6	-0.6	-0.7	-0.7	1.1
Sitting height	0.2	1.5	4.6	1.4	-1.0	-1.1	-0.3	0.1	-2.1
Chronic bronchitis/emphysema (father)	2.0	2.3	5.0	-0.3	-1.4	-1.4	-2.2	-1.8	-1.4
High blood pressure (mother)	0.7	1.0	2.5	-0.2	-0.6	-0.7	-1.1	-1.6	-1.2
Body mass index (BMI)	1.7	7.3	15.9	-0.1	4.0	3.9	2.8	1.6	-1.4
Impedance of leg (left)	1.5	7.1	16.4	-0.3	-2.8	-2.6	-4.0	-3.3	0.5
Leg predicted mass (left)	0.7	3.6	6.2	1.3	2.0	1.9	2.5	2.1	-1.3
Trunk fat mass	1.3	5.8	13.7	0.0	3.7	3.6	1.9	1.1	-1.8
Waist circumference	2.6	9.4	18.7	-0.9	4.3	4.3	3.3	1.7	-2.1
Number of incorrect matches in round	0.5	0.9	1.5	-0.6	0.9	1.0	-1.2	-1.2	0.3
Past tobacco smoking	0.6	1.2	4.6	2.1	-0.2	-0.1	-0.1	0.4	1.5
Alcohol usually taken with meals	3.0	4.9	10.1	-1.3	3.2	3.1	1.9	1.3	1.5
Nervous feelings	1.2	2.2	5.3	-2.3	-0.4	-0.3	-1.6	-2.2	-0.6
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	4.1	-2.0	-0.8	-0.6	-0.3	-1.3	-1.9
Hearing difficulty/problems with background noise	1.4	2.3	4.3	-1.5	1.3	1.4	-1.0	-1.6	-2.1
Hair/balding pattern: Pattern 2	0.7	0.9	3.1	1.8	-0.4	-0.4	0.5	0.6	1.1
Had menopause	3.4	4.2	8.7	0.9	2.2	2.0	2.5	3.0	0.6
Had other major operations	1.4	1.7	2.4	-1.3	1.5	1.5	1.3	1.0	-1.1
Forced vital capacity (FVC)	0.3	1.3	2.6	-0.4	-1.6	-1.5	-1.3	-1.0	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.2	-0.5	-0.7	-0.8	-0.5	-0.1
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.0	-0.3	-1.6	-1.6	-0.3	0.1	-2.0
Qualifications: None of the above	1.3	2.7	4.8	-1.4	2.2	2.2	-0.1	-1.0	-2.0
Financial difficulties in last 2 years	1.9	2.6	7.9	-1.3	1.4	1.4	1.1	0.9	-2.8
Mouth/teeth dental problems	0.6	0.9	2.3	0.3	-1.4	-1.5	-0.9	-0.1	-0.5
Heart attack	1.4	1.8	4.3	0.8	1.7	1.7	0.0	0.4	2.1
Allergy	0.2	0.4	1.5	-0.5	-0.4	-0.4	-0.7	-1.2	0.4
Pain all over the body in last month	1.3	1.4	2.6	-0.4	1.2	1.2	-0.6	-1.5	-1.6
Diabetes (self-reported)	0.6	0.9	2.2	0.0	1.5	1.4	0.7	0.2	-0.8
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	11.8	1.0	0.4	0.4	3.1	3.4	-0.0
Medication: Ramipril	0.3	0.4	1.4	-1.2	0.1	0.1	0.4	-0.3	-0.9
Medication: Simvastatin	1.0	1.5	2.7	0.4	1.6	1.6	1.3	1.4	0.1
Fluid intelligence score	0.2	0.4	1.6	-0.2	0.2	0.3	0.6	1.3	0.6
Illnesses of siblings	0.2	0.3	1.3	1.2	0.1	0.1	-0.0	0.2	-0.6
Neuroticism score	0.4	0.8	1.7	-1.2	-0.4	-0.3	-0.7	-1.3	-0.8
Weight	1.2	5.8	11.0	0.6	3.3	3.2	2.7	1.9	-1.6
Impedance of arm (right)	0.8	3.7	9.2	0.5	-3.0	-3.0	-1.9	-0.4	0.6
Arm fat percentage (right)	2.0	8.0	17.1	-0.4	4.1	4.1	2.8	1.9	-1.6
Trunk fat-free mass	0.4	2.6	3.7	1.6	1.8	1.8	1.9	1.6	-0.1
Hip circumference	1.9	8.1	13.3	0.7	3.5	3.5	3.6	3.0	-1.3
Time employed in main current job	4.0	4.6	10.3	1.0	-3.2	-3.2	-1.9	-1.5	0.3
Alcohol intake versus 10 years previously	1.2	1.7	4.7	0.0	2.1	2.2	0.9	0.3	0.6
Father’s age at death	0.3	0.5	1.7	1.3	0.5	0.4	0.3	0.7	0.4
Worrier / anxious feelings	0.7	1.4	2.9	-0.4	-1.1	-1.0	-1.2	-1.7	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.0	0.1	-1.0	-1.0	0.3	0.4	0.6
Falls in the last year	1.6	2.2	4.6	-2.1	1.4	1.3	1.8	0.9	-0.9
Hair/balding pattern: Pattern 3	1.1	1.6	2.3	-0.9	1.5	1.4	-0.8	-1.2	-1.5
Number of live births	1.6	2.2	3.8	0.5	1.9	2.0	1.6	1.4	1.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.1	0.1	-2.0	-1.9	-1.6	-1.4	0.5
Pulse rate	3.0	5.1	14.7	-1.9	1.0	0.8	3.8	2.8	1.7
Happiness	2.3	2.7	4.8	-2.2	-1.5	-1.5	-1.4	-2.0	-1.1
Noisy workplace	0.3	0.4	0.7	-0.3	-0.6	-0.5	0.8	0.9	0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.2	1.2	-0.7	-0.7	1.0	1.5	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.8	1.3	-0.7	-0.5	-0.9	-0.3	-0.6
Mouth/teeth dental problems: Dentures	0.9	1.5	3.0	-1.4	0.7	0.7	1.5	1.0	1.7
Asthma	1.4	2.8	4.0	0.5	2.0	2.0	1.7	1.7	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.0	0.2	0.2	0.8	0.6	0.4
Medication: Cholesterol lowering	1.7	2.7	4.9	0.3	1.9	2.0	1.8	2.2	0.5
Depression (self-reported)	1.4	1.6	4.5	0.3	-2.1	-2.0	-0.9	-0.3	0.4
Medication: Lansoprazole	0.1	0.2	0.4	0.6	-0.4	-0.4	-0.2	-0.2	-0.4
Prospective memory result	0.3	0.3	1.5	1.2	-0.3	-0.3	0.0	0.6	0.1
Lung cancer (father)	1.1	1.2	3.1	-1.8	-0.4	-0.5	-1.1	-1.5	-0.7
Illnesses of mother	0.9	1.1	3.2	0.5	0.7	0.6	1.3	1.8	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	7.5	0.2	-2.7	-2.6	-2.2	-1.9	0.7
Pulse wave Arterial Stiffness index	0.3	0.4	0.9	-0.9	-0.8	-0.7	0.3	0.1	0.2
Impedance of arm (left)	0.5	2.2	5.5	0.2	-2.3	-2.4	-1.4	-0.3	-0.0
Arm fat mass (right)	2.0	8.0	18.2	0.0	4.3	4.2	2.7	1.8	-1.4
Trunk predicted mass	0.5	2.6	3.7	1.6	1.9	1.8	1.9	1.6	-0.1
Standing height	0.1	1.0	3.2	1.8	-1.0	-1.0	-0.2	0.7	-0.4
Length of working week for main job	0.3	0.4	1.5	-0.4	-0.5	-0.4	-0.3	-1.2	0.2
Exposure to tobacco smoke at home	1.8	2.0	3.3	-1.3	1.5	1.4	1.3	1.0	-1.8
Breastfed as a baby	1.1	1.4	4.0	-0.0	1.9	2.0	0.6	-0.0	0.4
Tense / ‘highly strung’	1.2	1.9	9.1	-3.0	-0.2	-0.1	0.3	-1.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.3	-0.5	-0.4	-0.4	0.1	-0.4
Hair/balding pattern: Pattern 4	0.6	1.4	5.2	-2.3	1.0	1.1	0.9	0.1	-0.6
Birth weight of first child	0.4	0.8	1.6	0.3	0.4	0.5	1.1	1.2	1.2
Peak expiratory flow (PEF)	0.3	0.7	2.3	-0.7	-0.4	-0.3	-0.5	-0.9	-1.5
Pulse wave reflection index	0.9	1.1	2.9	0.1	0.5	0.6	-1.7	-1.5	-0.7
Ever highly irritable/argumentative for 2 days	1.7	2.0	3.5	-0.2	1.7	1.7	1.6	1.9	0.3
Loud music exposure frequency	0.5	0.5	0.7	-0.9	-0.8	-0.7	-0.6	-0.8	0.2
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	3.0	1.7	-0.7	-0.6	0.4	1.1	0.7
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	0.4	0.2	0.3	-0.1	-0.3	-0.3
Blood clot in the leg (DVT)	0.7	0.9	1.8	1.0	-1.2	-1.3	-0.6	0.1	0.7
Medication: Paracetamol	0.2	0.4	2.1	0.2	0.0	0.0	-0.3	-0.3	1.4
Headache pain in last month	0.5	0.9	1.8	0.3	1.2	1.3	0.6	0.6	1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.0	0.7	-1.4	-1.4	-1.1	-0.9	0.7
Glaucoma (self-reported)	1.1	1.3	3.3	0.7	1.3	1.2	0.3	0.8	1.8
Gout (self-reported)	1.3	1.7	3.9	1.0	-2.0	-1.9	-0.9	-0.7	0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.8	0.9	-0.7	-0.7	-0.5	-0.6	0.6
Medication: Amlodipine	0.5	0.8	2.0	-0.8	0.8	0.9	1.4	0.7	-0.0
Medication: Ventolin 100micrograms inhaler	1.8	2.3	3.8	0.3	1.8	1.7	1.9	1.9	-0.1
Birth weight	1.8	3.9	11.6	-0.0	-3.4	-3.4	-0.2	-0.1	0.3
Chronic bronchitis/emphysema (mother)	3.2	3.7	7.7	-1.8	2.8	2.7	0.8	0.3	-1.7
High blood pressure (siblings)	0.4	0.6	1.9	-1.4	0.7	0.6	0.9	0.4	0.1
Forced vital capacity (FVC), Best measure	1.0	3.5	5.5	-0.5	-2.3	-2.2	-2.3	-2.1	1.0
Body fat percentage	1.5	5.9	14.2	-0.6	3.8	3.7	1.8	0.8	-1.9
Leg fat percentage (right)	1.7	6.0	14.0	-1.0	3.7	3.7	2.2	1.2	-1.1
Arm fat-free mass (right)	0.6	3.1	6.1	1.1	2.5	2.4	1.6	0.8	-1.3
Exposure to tobacco smoke outside home	0.8	1.0	2.4	-1.3	0.1	0.1	-1.5	-1.3	-0.5
Comparative body size at age 10	0.8	2.1	3.5	1.4	-1.6	-1.6	-1.9	-1.2	0.8
Number of full brothers	1.1	1.4	3.3	0.1	1.3	1.3	-0.6	-1.1	-1.8
Worry too long after embarrassment	0.2	0.3	0.8	-0.6	-0.7	-0.5	-0.3	-0.9	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.3	0.7	-1.1	-1.0	-0.2	0.3	0.5
Wheeze or whistling in the chest in last year	0.5	0.8	1.7	-1.3	0.9	0.8	0.9	0.6	-0.7
Number of children fathered	0.6	0.7	1.5	-0.0	1.2	1.0	-0.2	-0.2	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.3	-1.0	0.7	0.6	1.5	1.3	-0.5
Age at first live birth	0.2	0.3	0.7	0.6	-0.9	-0.7	-0.1	0.1	-0.3
Pulse wave peak to peak time	0.4	0.4	1.5	1.2	0.7	0.7	-0.3	-0.0	-0.2
Health satisfaction	0.4	0.5	1.2	-1.1	-0.4	-0.5	1.0	0.4	-0.2
Shortness of breath walking on level ground	1.4	1.7	2.4	-1.5	1.5	1.5	1.3	0.6	-1.1
Qualifications: College or University degree	0.3	0.8	1.5	0.9	-0.9	-0.8	-1.0	-0.2	1.2
Eye problems/disorders: None of the above	0.5	0.6	1.1	0.4	-1.0	-1.1	-0.8	-0.4	0.8
Mouth/teeth dental problems: Loose teeth	1.9	2.2	4.5	0.4	1.5	1.5	2.1	1.6	-1.2
Emphysema/chronic bronchitis	0.8	0.9	2.8	-1.7	0.9	1.0	0.0	-0.2	0.8
Medication for pain relief, constipation, heartburn	0.7	1.3	6.5	-0.2	-0.6	-0.6	-0.4	-0.4	-2.6
Neck or shoulder pain in last month	0.5	0.7	2.1	-1.4	-0.8	-0.9	0.3	-0.3	-0.6
Medication: Blood pressure	1.3	2.3	4.4	-0.6	2.1	2.1	1.7	1.3	-0.0
Angina (self-reported)	1.1	1.4	3.5	-0.8	1.8	1.9	-0.1	-0.8	-0.5
Migraine (self-reported)	1.8	2.3	4.8	2.2	-1.6	-1.5	-0.7	0.2	1.9
Medication: Ibuprofen	0.4	0.4	1.0	-0.6	0.6	0.6	1.0	0.4	0.6
Medication: Allopurinol	0.3	0.4	0.8	0.9	-0.8	-0.7	0.2	0.5	-0.3
Medication: Omeprazole	0.8	1.0	3.4	1.1	0.2	0.0	0.8	1.9	0.8
Medication: Seretide 50 evohaler	0.8	0.9	2.1	-0.5	0.3	0.3	-1.3	-1.1	-1.4
Mean time to correctly identify matches	0.7	1.3	3.1	-1.8	0.2	0.2	1.6	1.4	-0.0
Heart disease (mother)	1.0	1.3	2.1	1.1	-1.1	-1.2	-1.4	-0.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	0.9	0.5	0.6	0.1	0.3	-0.3
Whole body fat mass	1.5	6.2	13.7	-0.1	3.7	3.6	2.3	1.4	-1.8
Leg fat mass (right)	1.8	6.9	15.6	-0.4	4.0	3.9	2.4	1.4	-1.6
Arm predicted mass (right)	0.5	2.6	5.6	1.2	2.4	2.3	1.3	0.5	-1.0
Pulse rate, automated reading	6.5	21.1	42.6	-2.1	4.3	4.3	6.5	6.0	2.4
Alcohol intake frequency.	0.5	1.2	2.5	1.1	1.6	1.5	0.9	0.5	-0.1
Comparative height size at age 10	0.2	0.9	1.8	1.3	-0.2	-0.3	1.0	1.3	-0.9
Number of full sisters	1.0	1.2	3.7	0.4	1.7	1.9	0.4	-0.3	-0.0
Suffer from ‘nerves’	1.9	2.9	7.9	-2.0	0.4	0.4	-2.0	-2.8	-1.1
Overall health rating	0.2	0.3	0.6	-0.8	0.6	0.6	0.0	-0.7	0.3
Chest pain or discomfort	0.8	1.2	2.9	-1.1	0.9	0.9	1.7	1.0	0.6
Had major operations	1.7	2.0	2.9	1.4	1.5	1.6	1.2	1.7	1.1
Age at last live birth	0.3	0.4	0.7	0.6	-0.6	-0.5	0.8	0.7	-0.4
Family relationship satisfaction	0.4	0.5	1.0	-0.5	-0.5	-0.5	-0.7	-1.0	-0.9
Leg pain on walking	1.5	1.8	5.1	-1.3	1.0	1.0	2.3	1.4	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.3	1.0	-1.1	-1.1	-0.3	0.3	0.8
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.5	0.7	-0.0	-0.2	-0.0	-0.0	0.1
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	8.6	-0.1	-1.2	-1.1	-0.4	0.0	2.9
Medication: Aspirin	1.5	1.9	3.9	0.1	1.4	1.4	1.4	1.2	2.0
Supplements: Vitamin C	0.2	0.3	1.2	1.1	-0.2	-0.3	-0.3	0.4	0.3
Knee pain experienced in last month	0.2	0.3	0.6	-0.4	0.6	0.7	0.8	0.6	0.2
Hypertension (Self-reported)	0.5	1.5	3.1	-0.3	1.8	1.8	1.4	0.5	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	0.5	-1.1	-1.1	-0.1	0.3	0.6
Illnesses of father: Heart disease	0.3	0.5	0.9	-0.4	0.9	0.9	-0.4	-0.7	-0.3
Illnesses of siblings: Diabetes	0.2	0.2	0.7	-0.1	0.3	0.4	-0.6	-0.8	-0.3
Smoking status: Previous	1.3	1.9	5.6	-2.4	0.3	0.2	0.3	-0.4	-2.3
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	3.9	-0.3	-2.0	-1.9	-1.1	-1.1	-1.7
Whole body fat-free mass	0.5	3.0	4.3	1.8	1.9	1.9	2.1	1.7	-0.5
Leg fat-free mass (right)	0.6	3.1	4.9	1.4	1.8	1.8	2.2	1.8	-1.3
Arm fat percentage (left)	2.2	8.9	19.1	-0.6	4.4	4.3	2.9	1.8	-1.9
Average weekly red wine intake	0.8	1.1	2.8	-0.6	1.7	1.6	0.5	0.7	0.3
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.4	-1.3	1.6	1.5	0.5	-0.8	-0.1
Mood swings	0.4	0.8	2.0	-0.5	-1.4	-1.4	0.4	0.4	-0.5
Loneliness, isolation	1.7	2.4	5.5	-2.4	-0.8	-0.9	-0.5	-1.6	-2.1
Long-standing illness, disability or infirmity	0.3	0.5	1.5	-0.3	0.2	0.2	1.2	0.8	-0.6
Ever had bowel cancer screening	1.1	1.3	4.3	-0.3	0.9	0.7	1.5	2.1	-0.0
Diabetes diagnosed by doctor	1.3	2.1	5.0	-0.1	2.2	2.2	1.1	0.5	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.0	0.3	-0.1	-0.1	0.5	0.5	1.4
Friendships satisfaction	1.0	1.3	3.5	-1.9	-0.0	-0.1	-0.8	-1.5	-1.1
Qualifications: nursing, teaching	0.3	0.5	1.4	0.8	-0.5	-0.5	-0.3	-0.3	1.2
Commuting to job workplace: Walk	0.4	0.4	0.7	0.4	0.6	0.6	0.7	0.8	-0.6
Eye problems/disorders: Cataract	0.2	0.3	0.9	0.0	-0.2	-0.2	-0.7	-1.0	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	7.2	-0.7	2.6	2.7	0.4	-0.3	-0.8
Medication for cholesterol	1.4	2.1	5.4	0.3	-2.3	-2.2	-0.8	0.3	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.7	9.5	-1.0	3.0	3.1	1.4	0.2	0.9
Back pain experienced in last month	2.0	2.9	5.4	-1.4	2.3	2.3	1.4	1.1	1.0
Mineral and other dietary supplements	0.4	0.6	1.3	-1.1	0.8	0.8	-0.1	-0.9	0.4
Breast cancer (self-reported)	0.4	0.4	0.9	0.7	-0.9	-0.9	-0.5	0.3	-0.4
Asthma (self-reported)	1.2	2.4	3.5	0.5	1.8	1.9	1.5	1.6	-1.6
Osteoporosis (self-reported)	0.7	0.8	3.3	-0.9	0.7	0.6	-0.3	-0.2	-1.8
Osteoarthritis (self-reported)	0.6	0.8	2.6	-0.4	-0.4	-0.4	1.6	1.3	-0.4
Medication: Aspirin	2.0	2.6	3.5	0.2	1.8	1.8	1.9	1.5	1.7
Medication: Gliclazide	1.7	1.9	4.9	-0.3	2.2	2.2	0.9	0.8	-0.6
Illnesses of father: None of the above (group 1)	0.9	1.1	3.0	-0.2	1.1	1.1	1.7	1.0	0.6
Smoking status: Current	1.3	2.1	7.8	1.8	-0.3	-0.4	0.2	1.0	2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.0	0.5	-1.7	-1.6	-0.2	0.3	-0.1
Whole body water mass	0.5	3.1	4.5	1.6	2.0	1.9	2.1	1.8	-0.7
Leg predicted mass (right)	0.6	3.2	5.0	1.4	1.9	1.8	2.2	1.8	-1.4
Arm fat mass (left)	2.2	8.9	19.2	0.1	4.4	4.3	3.0	2.0	-1.6
Number of self-reported non-cancer illnesses	0.9	1.5	3.3	0.4	1.1	1.1	1.6	1.8	0.6
Average weekly champagne plus white wine intake	0.2	0.3	0.6	-0.2	-0.8	-0.8	0.5	0.4	0.3
Miserableness	0.4	0.7	2.3	-1.5	0.2	0.2	-0.0	-0.7	-1.2
Guilty feelings	1.5	2.2	4.4	-0.0	-1.4	-1.3	-2.0	-2.1	-1.0
Wears glasses or contact lenses	2.2	2.5	5.7	0.7	1.2	1.5	1.3	1.9	2.4
Ever taken oral contraceptive pill	0.6	0.7	1.4	-1.1	0.2	0.2	1.2	1.1	0.1
Hearing aid user	0.6	0.7	1.4	0.1	1.0	1.0	0.4	0.6	1.2
Mother’s age at death	1.4	1.8	3.2	1.8	-1.2	-1.2	-1.6	-1.1	1.0
Financial situation satisfaction	1.5	1.9	3.7	1.5	-1.8	-1.9	-0.2	0.1	1.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.7	-0.2	-0.2	-0.4	-0.5	-0.3
Commuting to job workplace: Public transport	1.0	1.2	2.7	-1.0	0.4	0.5	1.1	1.3	1.6
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	0.2	1.0	1.0	-0.0	0.2	0.6
Medication: Blood pressure	1.0	1.9	4.5	-0.8	2.1	2.1	0.3	-1.2	0.8
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.0	-1.2	1.4	1.3	-0.0	-0.3	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.1	0.7	-1.4	-1.4	0.3	1.3	0.3
High cholesterol (Self-reported)	1.0	1.8	3.2	-0.7	1.8	1.6	1.6	1.2	0.6
Medication: Bendroflumethiazide	0.2	0.3	0.4	-0.7	-0.6	-0.7	-0.3	-0.4	0.5
Medication: Paracetamol	0.7	1.1	2.3	-0.2	0.8	0.8	1.3	1.3	1.5
Medication: Lisinopril	0.3	0.4	0.8	0.5	0.7	0.7	-0.5	-0.5	0.9
Medication: Atorvastatin	5.1	6.3	11.8	-0.9	3.4	3.3	3.1	2.1	0.6
Illnesses of father: High blood pressure	0.3	0.4	0.9	-0.6	-0.1	-0.0	-0.5	-0.9	-0.9
Alcohol drinker status: Never	0.4	0.5	1.1	1.1	0.4	0.5	-1.0	-0.8	-0.0
Ever smoked	0.7	1.2	3.8	-1.9	-0.2	-0.3	-0.9	-1.2	-1.1
Basal metabolic rate	0.6	3.6	5.4	1.4	2.3	2.3	2.2	1.8	-1.0
Leg fat percentage (left)	1.5	5.5	14.0	-0.8	3.7	3.7	1.6	0.7	-1.2
Arm fat-free mass (left)	0.6	3.2	6.2	1.2	2.5	2.5	1.8	1.1	-0.9
Number of operations (self-reported)	1.3	1.9	5.3	0.7	0.9	0.9	1.9	2.3	-0.6
Average weekly beer plus cider intake	1.4	2.0	3.4	0.5	-1.6	-1.6	-1.8	-1.7	0.0
Irritability	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.2	0.1	0.4
Risk taking	0.7	1.0	3.2	1.8	-0.5	-0.4	-1.3	-0.6	-0.8
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.9	-0.1	1.0	1.2	1.3	1.4	0.6
Fractured/broken bones in last 5 years	0.8	1.1	3.0	0.9	0.6	0.6	1.4	1.7	0.2
Age started oral contraceptive pill	0.9	1.1	2.7	1.6	-0.4	-0.5	0.3	1.0	1.6
Diastolic blood pressure, automated reading	1.2	3.7	8.8	-0.7	1.5	1.6	3.0	2.4	1.5
Ever depressed for a whole week	2.3	2.9	6.5	0.6	-2.6	-2.6	0.7	1.1	-1.5
Unable to work because of sickness or disability	1.1	1.4	3.7	-1.0	-1.4	-1.3	-0.1	-0.1	-1.9
Commuting to job workplace: Cycle	1.3	1.5	2.8	-0.2	0.8	0.9	-1.6	-1.7	-1.5
Myopia	1.6	2.4	6.2	-0.7	-1.6	-1.7	-1.3	-0.8	-2.5
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.2	0.6	-2.1	-2.1	-0.9	-0.1	-0.2
Cholesterol lowering medication	1.3	1.9	4.2	-0.2	2.0	1.9	1.5	0.7	0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.4	1.1	-0.2	-0.3	0.9	1.9	0.9
Pain experienced in last month	1.0	1.6	4.1	0.6	-2.0	-2.0	-0.8	-0.3	-0.8
Supplements: Calcium	0.4	0.5	1.2	1.0	-0.5	-0.5	-0.2	0.6	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.1	0.8	-1.0	-1.0	-1.0	-0.7	-0.5
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.4	0.9	1.8	1.8	0.0	0.3	1.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	0.7	-1.1	-1.3	-0.5	-0.1	1.0
Heart disease (siblings)	1.0	1.3	2.8	-1.1	1.7	1.6	0.2	-0.0	1.0
Alcohol drinker status: Previous	0.5	0.5	1.5	-1.1	0.4	0.4	0.1	-0.5	-1.2
Pack years of smoking	0.1	0.1	0.3	0.3	-0.2	-0.3	-0.2	-0.5	0.5
Impedance of whole body	1.0	5.2	9.2	-0.0	-3.0	-3.0	-3.0	-2.0	-0.2
Leg fat mass (left)	1.7	6.5	15.1	-0.2	3.9	3.8	2.2	1.3	-1.6
Arm predicted mass (left)	0.6	3.0	5.6	1.6	2.4	2.3	1.4	1.0	-1.1