TWAS hub - COLQ

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1139	0.0412	1.4e-05	0.148	NA	0.132	NA	0.138	1.1e-11	NA	1.6e-10	NA	5.9e-11
2	GTEx	Brain Cerebellar Hemisphere	0.2050	0.0820	9.1e-04	0.278	NA	0.214	NA	0.211	7.8e-08	NA	3.5e-06	NA	4.1e-06
3	GTEx	Brain Cerebellum	0.3640	0.0880	7.7e-08	0.337	NA	0.296	NA	0.298	9.7e-11	NA	2.0e-09	NA	1.7e-09
4	GTEx	Esophagus Mucosa	0.0870	0.0430	8.0e-03	0.000	NA	-0.003	NA	0.005	3.1e-01	NA	6.3e-01	NA	1.5e-01
5	GTEx	Lung	0.8510	0.0257	0.0e+00	0.316	NA	0.405	NA	0.427	1.0e-24	NA	4.1e-33	NA	2.6e-35
6	GTEx	Skin Sun Exposed Lower leg	0.0740	0.0300	1.4e-03	0.004	NA	-0.002	NA	0.001	1.3e-01	NA	6.0e-01	NA	2.3e-01
7	GTEx	Spleen	0.2640	0.0970	4.8e-03	0.097	NA	-0.007	NA	0.084	1.8e-03	NA	5.2e-01	NA	3.6e-03
8	GTEx	Stomach	0.4900	0.0960	1.5e-04	-0.005	NA	-0.005	NA	0.008	7.1e-01	NA	7.3e-01	NA	1.3e-01
9	GTEx	Thyroid	0.1550	0.0640	5.2e-04	0.025	NA	0.027	NA	0.054	4.5e-03	NA	3.5e-03	NA	5.5e-05
10	ROSMAP	Brain Pre-frontal Cortex	0.0523	0.0217	1.3e-03	0.028	0.016	0.040	0.020	0.039	1.3e-04	3.5e-03	5.7e-06	1.2e-03	8.4e-06
11	YFS	Blood	0.0825	0.0225	1.3e-13	0.028	0.048	0.045	0.048	0.043	1.1e-09	2.5e-15	1.7e-14	2.0e-15	6.3e-14
12	TCGA	Thyroid Carcinoma	0.0410	0.0250	9.1e-03	0.001	0.012	0.003	NA	-0.002	2.4e-01	2.3e-02	1.5e-01	NA	5.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Medication: Atenolol	4.7	5.9	11.0	-3.2	3.3	3.3	-1.1	2.0	-0.5	3.0	2.8	-0.8	-1.8	3.2	1.5
Medication: Atorvastatin	4.6	5.7	14.2	-3.8	3.1	3.4	-1.0	-0.2	-3.2	2.4	1.7	-0.4	-2.4	2.6	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.1	4.8	10.4	-3.1	3.2	3.2	-0.7	0.8	-1.1	2.6	1.9	0.4	-0.3	3.1	2.2
Multivitamins +/- minerals	3.6	4.6	10.0	2.2	-3.2	-3.1	-1.0	1.0	0.9	-3.0	-1.4	-1.0	0.9	-2.7	-2.8
Time employed in main current job	3.6	4.1	11.4	2.9	-3.1	-3.4	1.2	-1.4	1.8	-2.6	-2.1	-0.1	0.0	-1.4	0.4
Pulse rate, automated reading	3.6	11.6	35.2	-4.0	3.9	4.3	-1.3	-1.1	-5.9	4.0	-0.0	0.3	-5.3	1.4	-2.1
Frequency of depressed mood in last 2 weeks	3.0	4.2	11.8	3.4	-2.9	-3.0	1.0	0.2	1.4	-2.2	-0.2	-0.5	1.7	-3.2	0.2
Medication: Gliclazide	3.0	3.4	8.4	-2.9	2.5	2.4	-2.4	-1.4	-1.7	1.0	1.4	-1.1	0.6	2.0	0.7
Waist circumference	2.9	10.7	24.6	-5.0	4.6	4.3	-3.9	-0.4	-3.5	2.6	1.6	-3.4	-1.5	3.6	0.5
Qualifications: None of the above	2.9	6.1	14.3	-3.7	2.5	2.6	-3.6	0.7	-0.5	0.8	1.5	-3.6	1.8	3.8	0.3
Chronic bronchitis/emphysema (mother)	2.9	3.3	9.3	-3.0	3.0	2.9	-0.6	-0.1	-1.1	1.8	-0.5	-1.1	0.4	2.6	0.6
Birth weight	2.8	6.1	16.0	4.0	-3.9	-3.9	1.4	-1.0	-0.0	-3.2	-1.7	-1.2	-1.8	-2.5	-0.4
Taking other prescription medications	2.7	4.2	9.1	-2.9	2.9	3.0	-2.2	0.6	-2.9	2.1	1.5	-1.2	-0.1	1.6	0.5
Had menopause	2.7	3.4	13.2	-2.2	2.1	2.1	-2.3	-0.1	-3.6	0.6	1.9	-1.1	-1.7	0.5	-0.6
Age at First Birth	2.6	3.8	12.2	3.0	-2.5	-2.6	1.4	-0.1	1.3	-1.0	-0.4	2.1	1.3	-3.5	0.1
Arm fat percentage (left)	2.6	10.3	25.1	-5.0	4.7	4.3	-3.8	-1.4	-3.4	2.6	1.4	-2.9	-0.8	3.4	0.1
Falls in the last year	2.5	3.4	11.4	-2.6	1.4	1.5	-3.4	-2.7	-1.4	0.3	-1.2	-1.6	-0.6	1.5	-1.2
Leg fat percentage (right)	2.5	9.1	24.6	-5.0	4.0	3.6	-3.9	-1.4	-2.8	1.5	0.1	-3.5	-0.9	3.9	-0.4
Arm fat percentage (right)	2.4	9.5	22.6	-4.8	4.4	4.1	-3.5	-1.6	-3.5	2.4	1.6	-2.8	-0.9	3.4	0.3
Depression (self-reported)	2.4	2.9	7.5	2.7	-2.2	-2.3	1.7	1.4	1.6	-1.4	-0.3	1.3	0.7	-2.3	-0.7
Leg fat mass (right)	2.4	9.2	22.9	-4.8	4.2	3.7	-3.7	-1.4	-3.0	2.1	0.7	-3.4	-1.1	3.7	0.2
Arm fat mass (left)	2.4	9.9	23.8	-4.9	4.6	4.2	-3.2	-1.6	-3.6	2.6	1.3	-2.8	-1.2	3.4	0.5
Ever depressed for a whole week	2.4	3.0	9.2	2.8	-2.5	-2.5	0.1	-0.2	-0.8	-1.8	-0.6	0.2	-0.4	-3.0	-1.1
Relative age of first facial hair	2.3	4.7	12.8	3.1	-2.2	-2.7	2.4	-0.8	2.0	-0.5	-0.9	3.6	1.2	-3.1	0.1
Alcohol usually taken with meals	2.3	3.8	8.4	-2.9	2.8	2.8	-0.2	0.6	-1.7	1.6	1.3	0.9	-2.3	2.6	0.8
Leg fat percentage (left)	2.3	8.3	23.1	-4.8	4.0	3.6	-3.6	-0.8	-2.4	1.6	0.6	-3.2	-0.6	4.0	0.2
Serious illness, injury or assault to yourself	2.2	2.6	10.4	-2.0	1.4	1.3	-1.7	-3.2	-2.8	0.7	-0.4	-0.9	-1.1	0.3	-0.0
Body mass index (BMI)	2.2	9.3	22.2	-4.7	4.2	3.9	-3.4	-1.4	-3.3	2.5	1.0	-3.2	-1.1	3.6	0.4
Arm fat mass (right)	2.2	9.1	21.3	-4.6	4.5	4.0	-3.0	-1.6	-3.3	2.7	1.4	-2.5	-1.2	3.4	0.8
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	9.2	-2.2	2.7	2.2	-0.3	1.5	-0.8	1.8	1.9	-1.2	-0.1	3.0	2.1
Leg fat mass (left)	2.2	8.5	21.8	-4.7	4.1	3.6	-3.5	-1.1	-2.9	2.1	1.0	-3.1	-1.1	3.5	0.4
Rheumatoid Arthritis	2.1	2.8	10.2	-0.4	1.8	1.7	2.0	-1.0	2.1	2.1	-0.6	3.2	0.9	0.7	1.4
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	6.7	1.9	-2.5	-2.5	1.6	-0.7	-0.4	-2.6	-0.6	0.0	1.0	-1.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	7.0	-2.4	0.4	0.4	-2.6	0.2	-1.6	-0.8	-0.8	-2.3	-1.8	0.3	-1.9
Diabetes diagnosed by doctor	2.1	3.4	6.5	-2.0	2.3	2.5	-1.5	0.8	-2.0	1.8	2.4	-1.1	0.6	1.4	2.4
Medication for cholesterol	2.1	3.2	11.7	0.9	-2.3	-2.5	-0.6	-0.7	0.7	-1.8	-1.7	0.7	-0.2	-2.4	-3.4
Diabetes (mother)	2.0	2.6	8.3	-1.8	2.3	2.0	-1.8	1.3	-0.0	1.5	0.5	-0.9	0.8	2.9	1.0
Medication: Cholesterol lowering	2.0	3.1	7.8	-2.8	1.7	1.9	-1.2	1.4	-2.8	1.4	2.4	-0.4	-1.7	1.0	-0.1
Body fat percentage	2.0	7.8	20.4	-4.5	4.1	3.6	-3.6	-0.9	-2.5	1.9	1.2	-2.7	-0.4	3.4	0.4
Mouth/teeth dental problems: Loose teeth	2.0	2.3	4.2	-1.9	1.5	1.6	-1.8	0.5	-1.8	1.1	0.9	-1.6	-2.0	1.6	-1.2
Ever had bowel cancer screening	2.0	2.4	7.9	-2.1	0.8	0.6	-2.8	0.3	-2.1	-1.0	0.2	-0.9	-1.1	-0.6	-2.6
Type 2 Diabetes (T2D) (2018)	1.9	3.6	8.0	-1.9	2.5	2.8	-1.4	0.9	-1.2	2.2	2.0	-1.1	1.1	1.6	2.6
Medication: Metformin	1.9	2.7	6.5	-2.5	1.9	2.1	-1.0	-0.5	-2.3	1.1	2.5	-0.6	0.8	1.1	1.1
Supplements: Glucosamine	1.9	2.5	8.7	1.3	-1.8	-1.5	-1.9	0.3	-1.2	-2.1	0.2	-0.9	-0.1	-2.9	-1.9
Medication: Simvastatin	1.9	2.8	5.5	-2.3	1.7	1.6	-2.2	1.2	-2.0	0.5	2.2	-2.1	-0.9	1.4	-0.1
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	13.8	0.0	0.3	0.2	-0.5	2.3	-3.7	0.2	0.7	-0.7	-2.5	-0.8	-1.3
Whole body fat mass	1.8	7.5	18.1	-4.3	3.9	3.5	-3.3	-1.2	-2.9	2.0	1.2	-2.8	-1.0	3.1	0.3
Medication: Aspirin	1.8	2.4	6.6	-2.6	1.8	1.9	-1.2	0.4	-1.9	1.2	2.2	0.0	-1.2	1.6	-0.3
Financial situation satisfaction	1.8	2.3	8.6	1.4	-1.7	-1.7	0.2	-2.9	-0.4	-2.0	-1.4	-1.6	0.5	-1.2	-0.3
Hearing difficulty/problems: Yes	1.7	2.6	7.1	-1.8	2.7	2.5	-1.2	-1.7	-0.9	2.2	-1.2	-0.4	-0.1	1.7	0.6
Trunk fat percentage	1.7	6.6	17.2	-4.1	3.8	3.4	-3.2	-0.5	-2.3	1.8	1.7	-2.2	-0.2	3.0	0.7
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	10.6	-0.5	1.3	1.0	-0.5	3.3	0.4	0.8	0.8	-0.2	0.6	2.3	0.7
Pain all over the body in last month	1.7	1.8	8.3	-1.0	1.5	1.4	0.4	0.1	1.0	1.3	-1.4	-0.1	0.7	2.9	1.4
Pulse rate	1.7	2.8	12.4	-1.2	0.6	0.9	-0.4	-2.3	-2.6	1.0	-1.4	0.0	-3.5	0.3	-1.9
Number of full sisters	1.7	2.0	4.3	-1.4	2.0	2.0	0.2	0.7	-0.4	2.1	1.6	0.9	0.6	1.0	2.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	8.6	1.3	-1.3	-1.4	1.2	2.9	0.6	-1.5	1.4	0.9	-1.5	-1.0	-0.5
Medication: Blood pressure	1.7	3.3	14.2	-0.6	2.1	2.2	1.6	-0.4	0.3	2.2	1.2	0.7	0.3	2.4	3.8
HDL Cholesterol	1.6	2.6	7.2	2.6	-1.2	-1.4	2.7	-0.4	2.0	-0.6	-0.7	1.0	0.9	-0.7	2.6
Trunk fat mass	1.6	6.8	17.3	-4.2	3.9	3.4	-3.1	-0.8	-2.5	2.0	1.4	-2.3	-0.7	3.0	0.6
Hip circumference	1.6	7.0	16.9	-3.7	3.5	3.3	-2.7	-0.2	-4.1	2.3	1.8	-2.5	-2.2	1.9	-0.4
Ever highly irritable/argumentative for 2 days	1.6	1.9	4.9	-1.7	1.6	1.6	-0.6	-0.9	-2.2	2.1	-0.3	0.1	-1.8	1.0	-0.4
Medication: Ventolin 100micrograms inhaler	1.6	2.1	4.0	-1.9	1.8	1.8	-0.5	1.6	-2.0	1.2	2.0	-0.0	-1.4	0.7	-0.2
Commuting to job workplace: Walk	1.6	1.8	8.9	-1.3	0.6	0.3	-1.8	1.5	-1.2	0.0	3.0	-1.5	-0.7	0.3	-0.5
High cholesterol (Self-reported)	1.6	2.8	6.6	-2.6	1.7	1.9	-2.0	0.1	-1.8	0.5	1.0	-2.4	-1.1	2.2	0.2
BMI	1.5	8.9	20.8	-4.2	4.6	4.4	-2.8	-0.0	-2.7	2.9	2.0	-2.0	-0.8	3.9	1.5
Maternal smoking around birth	1.5	2.2	6.3	-1.6	0.3	0.3	-2.4	0.7	-2.0	-0.6	-0.6	-2.5	-0.5	1.2	-2.0
Relative age voice broke	1.5	2.3	14.1	0.6	0.6	0.4	2.1	-0.0	-1.2	1.7	0.5	3.8	-1.3	-1.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	12.5	3.5	-2.8	-3.0	2.4	-1.1	2.9	-1.6	-1.7	1.7	1.4	-1.7	-0.1
Number of children fathered	1.5	1.7	5.6	-2.0	1.3	1.2	-2.4	0.1	-0.1	0.4	0.6	-1.2	1.7	1.6	-0.4
Qualifications: College or University degree	1.5	4.6	17.7	2.5	-1.0	-1.3	3.8	-1.0	1.4	0.7	0.5	4.2	-0.5	-3.1	0.8
Back pain experienced in last month	1.5	2.2	5.9	-1.7	2.3	2.2	0.1	-0.7	-1.5	2.4	-0.7	0.8	-1.1	1.7	-0.0
Wears glasses or contact lenses	1.5	1.7	4.7	-0.6	1.1	1.2	1.2	0.3	-1.3	1.1	1.7	2.0	-2.2	0.2	-1.1
Number of treatments/medications taken	1.4	2.5	8.6	-2.0	1.3	1.8	-2.0	-0.4	-2.9	0.9	1.5	-1.7	-1.0	1.0	-0.3
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	8.4	-0.0	0.4	1.0	-0.5	-0.0	-2.9	1.2	1.4	-0.9	-2.0	-0.7	0.2
Stomach or abdominal pain in last month	1.4	1.7	11.7	-0.7	0.2	0.4	-2.1	-3.4	-0.8	-0.2	-0.9	-1.1	0.8	0.1	-0.1
Number of live births	1.4	2.0	4.4	-1.1	1.9	1.9	0.5	1.2	-1.8	2.1	2.1	0.6	-0.4	0.6	1.0
Happiness	1.4	1.7	5.2	0.3	-1.2	-1.1	-0.7	0.5	1.3	-1.9	-2.1	-1.2	2.3	-0.3	-0.7
Breastfed as a baby	1.4	1.7	5.2	-1.2	1.9	2.3	0.0	0.4	0.6	1.9	1.2	1.2	-0.3	1.7	0.2
Angina (self-reported)	1.4	1.8	4.0	-1.7	1.7	1.9	-1.1	1.0	-0.0	1.2	0.9	-0.5	0.9	2.0	1.8
Medication: Aspirin	1.4	1.8	5.0	-2.2	1.4	1.4	-1.4	0.6	-1.6	0.9	2.1	-0.1	-1.1	1.3	-0.1
Friendships satisfaction	1.4	1.8	8.5	-0.6	0.1	-0.1	-1.0	-2.5	0.5	-1.0	-2.9	-1.6	0.8	0.7	0.4
Medication: Lisinopril	1.4	1.8	6.0	0.2	0.8	0.7	2.4	-1.7	0.1	1.4	-1.5	1.6	0.6	1.1	1.8
Heart attack/myocardial infarction (self-reported)	1.4	1.9	4.2	-1.6	1.7	2.0	0.0	0.6	-0.6	1.0	1.7	0.2	0.2	2.0	2.0
Prostate Cancer	1.3	1.9	6.5	-0.9	1.5	1.1	0.1	1.3	0.8	1.7	0.7	-0.2	1.3	2.0	2.5
Diabetes (father)	1.3	1.7	7.0	1.1	-0.9	-0.5	-1.4	-2.6	-0.3	-0.6	-0.1	-0.7	2.1	-1.1	1.5
Had other major operations	1.3	1.6	4.1	-2.0	1.6	1.5	-1.3	-0.9	-1.5	0.9	-0.5	-1.1	-0.5	1.5	-0.9
Alcohol intake versus 10 years previously	1.3	2.0	6.0	-1.6	2.2	2.4	-0.5	-0.1	-0.6	2.0	0.5	1.5	0.0	1.4	1.1
Qualifications: A levels/AS levels or equivalent	1.3	2.8	7.3	1.9	-1.2	-1.2	2.7	0.2	-0.0	-0.2	0.2	2.6	-2.1	-2.4	-1.5
Pulse wave Arterial Stiffness index	1.3	1.5	6.2	-0.3	-0.9	-0.5	-1.3	-1.4	-0.2	-1.7	-2.5	-0.9	-0.5	0.2	-1.8
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	6.1	2.1	-0.8	-0.9	2.5	0.7	-0.2	0.2	0.6	2.4	-0.7	-2.2	-0.0
Number of full brothers	1.3	1.6	4.0	-1.8	1.3	1.3	-1.4	-2.0	-0.2	0.3	-1.1	-1.3	1.7	0.9	0.8
Pulse wave peak to peak time	1.3	1.5	6.9	0.4	0.8	0.4	1.4	1.2	0.2	1.5	2.6	0.9	0.5	-0.3	1.8
Had major operations	1.3	1.5	5.6	-0.7	1.5	1.5	0.4	0.2	-1.4	2.4	1.0	1.7	-1.4	0.3	0.2
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.6	-0.4	1.7	1.7	0.8	-1.0	0.5	1.9	-0.9	0.9	-0.5	1.7	1.9
Risk taking	1.3	1.9	12.1	-0.4	-0.2	-0.5	-1.5	-3.5	0.0	-0.6	-2.4	-0.7	1.4	0.1	0.0
Myopia	1.3	1.8	7.1	1.9	-1.4	-1.7	0.1	0.7	1.3	-0.8	-0.8	1.1	1.3	-2.7	-0.4
Cholesterol lowering medication	1.3	1.9	4.0	-1.1	2.0	1.8	0.1	0.5	-1.7	0.9	1.6	-1.2	-1.1	1.8	1.4
LDL Cholesterol	1.2	1.9	6.4	-1.0	1.9	2.2	0.8	0.7	-1.6	2.5	0.5	0.3	-1.5	1.1	0.6
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.7	-1.5	1.3	1.5	-2.1	-0.7	-2.2	0.4	0.4	-0.8	-0.4	-0.8	-0.4
Vitamin and mineral supplements	1.2	1.6	6.1	-0.6	1.4	1.6	1.0	-0.9	-0.0	1.7	1.0	1.0	-0.3	1.4	2.5
Fed-up feelings	1.2	2.1	5.3	2.0	-2.3	-2.2	-0.0	-1.2	0.4	-2.3	-0.3	-0.8	1.0	-1.8	-0.4
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	4.8	1.7	-1.4	-1.5	-0.6	-0.7	0.0	-0.9	-1.3	0.4	0.7	-2.2	-1.0
Financial difficulties in last 2 years	1.2	1.7	4.9	-1.7	1.4	1.1	-2.2	-0.9	-1.4	0.7	-0.9	-0.8	-0.6	-1.5	-1.3
Heart attack	1.2	1.5	4.0	-1.7	1.6	1.8	0.1	0.4	-0.5	0.9	1.3	0.2	-0.1	2.0	1.7
Weight	1.2	5.9	13.0	-3.6	3.4	2.9	-2.6	-1.3	-3.0	1.9	1.2	-2.5	-1.6	2.5	0.3
Gout (self-reported)	1.2	1.7	5.6	2.4	-1.7	-2.2	0.7	-0.8	0.8	-1.2	0.2	0.0	0.3	-1.8	0.8
Forced vital capacity (FVC), Best measure	1.2	4.3	10.5	3.1	-2.4	-2.7	2.5	-0.3	3.2	-1.2	-1.5	2.1	1.3	-1.4	0.1
Medication: Blood pressure	1.2	2.2	5.2	-2.1	2.2	2.2	-0.5	-0.3	-1.9	2.3	0.7	-0.4	-0.8	0.9	1.1
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.1	0.7	-1.5	-1.6	-0.9	0.4	-0.7	-1.5	0.2	-1.3	-0.5	-2.0	-1.9
Number of operations (self-reported)	1.2	1.8	6.2	-1.3	0.8	0.9	-1.7	-1.6	-2.5	0.8	0.4	-1.0	-1.7	0.0	-1.3
Ever had prostate specific antigen (PSA) test	1.2	1.3	3.6	-1.7	1.0	0.8	-1.0	0.1	-1.5	0.1	-0.5	-1.0	-1.9	1.2	-1.4
Depression (Nagel 2018)	1.1	1.7	4.6	1.7	-1.8	-2.0	0.4	0.2	1.1	-2.1	-0.6	-0.6	0.9	-1.6	-0.1
Alzheimer’s Disease (in mother)	1.1	1.3	4.4	-0.7	0.5	0.6	-2.1	0.6	-1.7	0.7	0.5	-1.6	-1.3	-0.4	-1.4
Major Depression (MDD)	1.1	1.4	4.7	0.4	0.5	-0.1	-0.0	-1.8	0.5	0.7	0.4	1.4	1.8	-1.4	2.2
Bipolar Disorder (2011)	1.1	1.0	2.8	1.0	-1.4	-1.2	1.5	-0.7	0.0	-1.0	-0.4	1.2	-0.1	-1.7	-0.4
Ever had hysterectomy (womb removed)	1.1	1.3	2.8	-0.3	-0.9	-0.7	-1.6	-0.5	-1.2	-1.5	0.1	-1.7	-1.3	0.4	-1.7
Angina	1.1	1.5	3.6	-1.5	1.4	1.6	-1.0	0.8	0.0	0.9	0.8	-0.7	1.0	1.9	1.7
Average weekly fortified wine intake	1.1	1.2	3.1	-1.3	0.4	0.6	-1.7	1.8	-1.3	-0.5	1.6	-0.7	-0.6	-0.2	-1.0
Impedance of leg (left)	1.1	5.4	14.4	3.0	-2.8	-2.7	2.4	1.1	3.8	-2.3	-1.4	1.9	2.4	-1.4	1.1
Diabetes (self-reported)	1.1	1.7	3.5	-1.2	1.4	1.7	-0.8	0.5	-1.6	1.0	1.8	-1.0	0.6	1.2	1.9
Asthma	1.1	2.2	4.4	-1.9	2.0	2.0	-1.3	0.5	-2.1	1.7	1.6	-1.2	-0.8	0.7	0.2
Exposure to tobacco smoke at home	1.1	1.2	3.2	-1.8	1.5	1.4	-0.4	1.0	-1.3	1.5	0.8	-1.0	-0.5	0.4	-0.5
Mean time to correctly identify matches	1.1	2.2	8.6	-1.6	0.3	-0.0	-2.2	-0.2	-1.9	-0.7	0.0	-1.4	-2.9	0.4	-2.0
Leg pain on walking	1.1	1.4	3.2	-1.5	0.9	1.2	-1.3	-0.5	-1.8	-0.1	0.2	-1.3	-1.5	1.2	-1.1
Osteoarthritis (self-reported)	1.1	1.4	4.7	0.3	-0.5	-0.4	-1.5	0.6	-1.6	-0.9	0.1	-2.2	-1.6	-0.7	-1.6
Commuting to job workplace: Public transport	1.1	1.3	4.9	0.6	0.4	0.4	2.2	1.7	-0.4	1.0	0.5	1.3	-1.9	0.0	0.2
Average weekly beer plus cider intake	1.1	1.5	4.2	1.6	-1.6	-1.4	0.7	0.0	1.9	-1.2	-2.0	-0.2	1.4	-0.0	0.2
Commuting to job workplace: Cycle	1.1	1.3	3.6	0.1	1.0	0.9	0.3	0.5	1.6	1.2	1.3	1.4	1.9	0.6	1.5
Pain experienced in last month	1.1	1.8	5.3	1.1	-2.1	-2.0	0.3	1.0	0.5	-2.3	1.2	-0.2	0.7	-1.9	-0.8
Body Mass Index (BMI) (2010)	1.0	1.4	3.5	-1.9	1.1	1.1	-1.4	0.5	-1.3	1.0	0.9	-0.4	-1.4	-0.2	-1.8
HbA1C	1.0	1.1	3.0	-0.6	-0.0	0.4	-0.0	1.1	-1.7	0.5	1.1	0.5	-1.7	-1.3	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	3.5	1.8	-1.4	-1.3	1.0	-1.1	0.5	-0.8	-1.2	1.1	0.1	-1.9	-0.6
Wheeze or whistling in the chest in last year	1.0	1.7	5.4	-1.8	0.8	0.4	-1.0	0.8	-1.3	0.3	-0.8	-2.1	-1.6	2.3	-0.5
Neck or shoulder pain in last month	1.0	1.4	4.7	0.4	-0.8	-0.4	-1.6	-1.8	0.2	-0.2	-1.8	-2.2	0.4	0.9	-0.6
Heart disease (mother)	1.0	1.3	3.8	1.6	-1.5	-2.0	0.7	0.6	0.8	-1.2	-0.8	0.4	-0.2	-1.0	1.4
Qualifications: nursing, teaching	1.0	1.5	4.9	1.4	-0.7	-0.5	2.2	-2.1	0.9	-0.0	-1.4	1.4	-1.0	-0.6	0.8
Mineral and other dietary supplements	1.0	1.3	5.2	-0.6	0.8	0.7	1.1	-1.4	0.4	1.0	-1.6	0.8	-0.9	2.3	0.9
Eye problems/disorders: Glaucoma	1.0	1.2	3.3	-1.3	1.2	0.9	-1.2	1.8	-0.6	0.6	1.8	-0.3	-0.2	1.0	-0.4
Impedance of whole body	1.0	4.9	10.4	3.2	-3.1	-2.9	1.6	0.3	2.7	-2.5	-1.2	1.4	2.2	-2.4	-0.3
Alzheimer’s Disease (in father)	0.9	0.9	2.5	1.5	-1.0	-0.5	1.6	-1.1	0.2	0.0	-1.6	0.7	-0.5	-0.7	0.5
Reaction Time	0.9	1.7	7.5	-0.5	-0.7	-0.8	-1.1	-0.5	-1.2	-0.9	-0.9	-1.1	-2.7	-0.0	-2.4
Average weekly spirits intake	0.9	1.1	3.0	-0.7	1.0	0.6	-0.8	-1.5	-0.9	-0.1	0.6	-1.7	0.7	1.3	1.3
Impedance of leg (right)	0.9	4.2	9.1	2.7	-2.7	-2.6	1.9	0.6	3.0	-2.2	-1.8	1.4	1.9	-1.5	0.3
Chronic bronchitis/emphysema (father)	0.9	1.0	2.7	0.4	-1.1	-1.5	-0.5	-0.1	1.7	-1.1	-0.3	-1.3	1.6	-0.1	-0.1
High blood pressure (mother)	0.9	1.2	4.3	1.5	-0.7	-0.8	1.5	-0.7	1.8	0.1	-0.2	0.0	0.9	0.4	2.1
Impedance of arm (right)	0.9	4.2	9.8	3.0	-3.1	-3.0	1.4	-0.6	1.1	-2.7	-0.1	1.2	1.1	-2.7	-0.9
Hair/balding pattern: Pattern 3	0.9	1.3	4.1	-0.8	1.4	1.4	0.4	-0.0	0.9	2.0	0.5	0.8	0.8	0.1	2.0
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	9.1	3.0	-2.1	-2.3	2.3	-0.3	2.1	-1.0	-1.2	1.6	1.3	-1.4	0.1
Mouth/teeth dental problems: Dentures	0.9	1.5	4.2	-2.0	0.9	0.8	-2.0	-0.2	-1.1	0.1	-0.1	-1.4	-0.8	1.6	-1.2
Illnesses of mother	0.9	1.2	3.9	-1.5	0.7	0.9	-0.9	-0.6	-1.8	0.3	0.9	0.7	-0.4	-0.8	-2.0
Hair/balding pattern: Pattern 4	0.9	2.2	7.4	-1.2	1.2	1.2	-1.1	2.2	-1.3	0.6	1.0	-2.7	-0.8	1.9	1.0
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.5	1.9	-1.5	-1.4	1.3	-0.7	1.4	-1.5	-1.6	0.5	0.4	-0.6	-0.5
Shortness of breath walking on level ground	0.9	1.1	2.1	-1.2	1.4	1.3	0.1	1.0	-1.4	0.8	1.0	-0.9	-0.6	1.4	0.5
Eye problems/disorders: None of the above	0.9	1.0	2.8	1.7	-1.3	-1.5	1.2	0.2	1.2	-1.1	-0.3	0.6	0.2	-0.9	-0.2
Medication: Ibuprofen	0.9	1.0	6.8	-0.8	0.4	0.3	-0.4	2.6	-0.1	0.2	0.9	-0.2	-1.6	0.4	-1.1
Suffer from ‘nerves’	0.9	1.5	7.7	0.6	0.7	0.2	1.1	1.0	2.8	0.2	-0.2	1.1	1.4	0.5	1.8
Smoking status: Previous	0.9	1.4	4.1	-1.5	0.4	0.2	-1.5	-2.0	0.2	-0.1	-1.3	-1.4	1.0	1.1	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	4.5	2.1	-2.1	-2.0	1.4	0.8	1.7	-1.7	-0.6	-0.5	0.5	-0.8	-0.2
Asthma (self-reported)	0.9	1.8	3.7	-1.8	1.8	1.9	-1.1	0.4	-1.9	1.6	1.7	-0.8	-0.5	0.5	0.2
Number of self-reported non-cancer illnesses	0.9	1.6	6.1	-1.9	1.2	1.4	-1.8	-0.8	-2.5	0.6	0.4	-0.9	-0.5	0.7	-0.7
Guilty feelings	0.9	1.3	3.7	1.4	-1.1	-1.6	1.1	-0.0	1.9	-1.1	-0.3	0.2	1.5	-0.2	1.3
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.5	-1.4	1.3	1.2	-0.8	-1.3	-0.5	0.8	-1.1	-0.2	0.2	1.9	0.7
Unable to work because of sickness or disability	0.9	1.1	4.9	0.6	-1.2	-1.1	-1.2	0.1	-0.2	-1.4	-0.7	-2.2	0.8	0.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	4.0	0.3	-0.1	0.2	-0.6	-1.1	-2.0	-0.6	1.7	-0.9	-0.6	-1.5	-0.2
Primary Biliary Cirrhosis	0.8	1.2	5.6	-1.1	1.2	1.1	0.1	1.0	-1.4	0.8	0.3	0.9	-2.4	-0.4	-0.3
Blood Red Count	0.8	7.3	15.4	-3.9	3.5	3.2	-1.6	2.7	-3.9	2.2	2.6	-0.5	-2.7	2.2	0.3
Waist Hip Ratio (WHR)	0.8	3.8	10.2	-3.1	2.4	2.7	-3.2	0.9	-0.6	1.1	0.3	-1.9	-0.2	2.4	0.2
Cardiovascular Disease	0.8	2.7	7.1	-1.5	2.2	2.5	0.4	0.8	-0.8	2.7	2.0	-0.0	-0.3	1.3	2.2
Blood clot in the leg (DVT)	0.8	1.1	5.0	0.4	-1.2	-1.2	-0.5	-1.5	0.3	-2.2	-0.0	-0.7	1.2	0.1	-0.7
Comparative body size at age 10	0.8	2.3	7.5	1.2	-1.5	-1.7	1.3	-2.4	1.6	-1.1	-2.7	0.7	1.1	-0.8	-0.3
Migraine (self-reported)	0.8	1.0	2.8	1.1	-1.6	-1.5	0.8	-1.7	0.4	-1.1	0.0	0.2	0.3	0.1	-0.8
Medication: Omeprazole	0.8	1.0	4.8	-0.5	0.2	0.3	-0.7	-0.5	-2.2	-0.6	1.6	-0.8	-0.2	-1.2	-0.5
Chest pain or discomfort	0.8	1.2	4.0	0.1	0.8	0.5	1.4	2.0	-1.1	1.4	0.4	0.6	-1.5	1.2	-0.4
Mood swings	0.8	1.5	4.1	0.7	-1.3	-1.2	-1.5	-0.9	-0.5	-1.9	-0.4	-2.0	-0.6	-1.3	-1.2
Hearing aid user	0.8	0.9	4.1	-1.2	0.9	0.6	-0.2	-0.3	-0.9	0.8	-0.6	-0.8	-1.1	2.0	-0.2
Diastolic blood pressure, automated reading	0.8	2.5	17.3	-1.2	1.2	1.2	-0.2	0.4	-2.2	1.4	0.4	-0.7	-4.2	0.3	-0.7
Vascular/heart problems diagnosed by doctor	0.8	2.2	4.7	1.7	-2.0	-2.2	0.3	0.3	1.1	-1.9	-1.2	0.6	0.7	-1.9	-2.0
Basal cell carcinoma (self-reported)	0.8	1.0	4.5	1.5	-1.1	-0.9	2.1	-0.1	1.1	-0.9	-0.3	0.7	-0.0	-0.5	0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	5.5	0.2	-1.2	-1.1	-0.7	-1.3	0.2	-2.3	-0.2	-0.8	1.1	0.3	-0.8
Heart disease (siblings)	0.8	1.0	2.8	-1.4	1.7	1.7	-1.0	-0.6	-0.5	1.0	0.0	0.2	-0.7	1.2	0.8
Respiratory disease	0.7	1.6	3.5	-1.7	1.8	1.8	-1.0	0.6	-1.9	1.6	1.0	-0.1	-0.3	0.7	-0.0
Supplements: Zinc	0.7	0.8	1.8	0.1	-0.7	-0.4	-0.5	1.3	1.2	-1.0	-0.2	-1.3	0.9	0.9	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.3	1.0	-0.8	-1.2	0.1	1.5	1.4	-1.0	-0.2	-1.2	1.0	0.1	0.7
Qualifications: CSEs or equivalent	0.7	0.9	3.9	1.1	-0.7	-0.8	2.0	-0.3	0.5	0.6	-0.5	1.5	0.8	-0.2	1.1
High blood pressure	0.7	1.9	4.5	-1.4	1.8	1.9	0.0	-0.5	-1.1	1.8	1.0	-0.4	-0.4	1.8	2.1
Hearing difficulty/problems with background noise	0.7	1.1	2.3	-0.9	1.5	1.1	0.2	-0.4	1.2	1.1	-0.3	0.6	1.3	1.5	1.3
Mouth/teeth dental problems	0.7	1.1	3.5	1.1	-1.4	-1.3	-0.1	0.1	0.2	-1.7	-0.8	0.6	0.1	-1.9	-0.9
Worrier / anxious feelings	0.7	1.4	6.1	1.5	-0.9	-1.3	1.6	2.5	1.4	-0.8	-0.2	-0.2	-0.4	-0.5	0.5
Headache pain in last month	0.7	1.2	3.1	-0.4	1.3	1.1	1.4	-0.3	-0.3	1.8	1.1	1.6	-0.1	-0.0	1.6
Medication: Seretide 50 evohaler	0.7	0.8	2.4	0.9	0.4	0.4	1.5	0.3	0.8	0.7	-0.2	0.5	1.5	-0.4	1.6
Hypertension (Self-reported)	0.7	1.8	3.8	-1.4	1.6	1.9	0.0	-0.4	-1.6	1.7	1.2	-0.6	-0.7	1.4	1.9
Average weekly red wine intake	0.7	1.0	2.5	-1.1	1.5	1.6	0.4	0.7	-1.0	0.9	1.2	1.1	0.0	-0.1	1.0
Average weekly champagne plus white wine intake	0.7	1.0	3.9	-0.2	-0.9	-1.1	0.1	-0.9	-0.4	-2.0	-0.9	-0.8	-1.3	0.7	-1.2
Mother’s age at death	0.7	0.9	2.6	0.6	-1.0	-1.1	1.3	0.1	1.2	-1.6	0.6	0.9	0.5	-0.6	0.7
Tinnitus: Yes, now most or all of the time	0.7	0.8	5.8	0.4	0.2	0.2	0.3	-2.4	0.7	0.9	-0.4	0.6	0.9	-0.0	1.2
Illnesses of father: High blood pressure	0.7	0.8	4.5	0.6	-0.1	-0.0	1.4	1.2	0.5	1.0	0.8	0.3	0.2	-0.0	2.1
Fractured/broken bones in last 5 years	0.7	0.9	4.5	-0.2	0.2	0.5	-1.5	-1.3	-2.1	0.3	-0.1	-0.6	-0.6	-1.1	-0.7
Age started oral contraceptive pill	0.7	0.8	3.6	0.9	-0.6	-0.6	0.6	0.7	-0.8	-1.0	1.9	-0.5	-0.4	-1.4	0.2
Worry (Nagel 2018)	0.6	1.2	6.1	0.2	1.1	0.6	0.4	1.5	2.5	0.3	-0.4	0.5	0.8	1.0	1.4
Crohns Disease (2017)	0.6	1.3	2.5	1.0	-1.5	-1.0	0.7	1.1	1.4	-1.6	0.7	1.1	1.3	-0.8	-0.9
Coronary Artery Disease (CAD)	0.6	0.7	2.5	-1.6	1.2	1.2	-0.0	-0.1	0.1	0.5	-0.3	-0.1	-1.1	0.9	-0.0
Mean Putamen Volume	0.6	0.7	2.1	0.5	0.2	0.3	1.0	0.1	-1.0	0.8	0.3	1.2	-0.1	-1.4	1.2
Neuroticism (2016)	0.6	0.9	3.4	-0.4	0.0	-0.5	-0.3	0.9	0.7	-1.6	0.8	-1.8	0.5	1.4	0.3
Triglycerides	0.6	1.1	3.3	-0.9	1.5	1.5	-0.3	0.7	-1.1	1.8	1.1	0.9	0.1	-0.0	-0.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.2	-1.3	0.6	0.3	-0.8	-1.1	0.5	-0.4	-0.6	0.1	0.1	0.6	-1.8
Hypothyroidism (self reported)	0.6	1.3	5.5	1.2	-1.2	-0.9	0.0	-1.2	1.1	-1.3	-0.4	-0.7	2.4	0.3	0.8
Number of incorrect matches in round	0.6	0.9	2.6	-0.8	1.0	1.0	1.3	-0.5	0.8	0.8	-0.2	1.6	0.1	0.6	1.5
Forced vital capacity (FVC)	0.6	2.2	6.2	2.5	-1.7	-1.9	2.0	0.4	2.0	-0.6	-0.6	1.5	1.1	-1.3	-0.3
Father’s age at death	0.6	0.8	3.0	-0.2	0.4	0.8	-1.7	1.3	-0.9	0.3	1.5	-0.1	0.6	-0.6	-0.1
Noisy workplace	0.6	0.7	2.8	0.0	-0.7	-0.7	0.2	0.0	-1.0	-0.3	-1.7	-0.6	-1.6	-0.0	-0.6
Medication: Lansoprazole	0.6	0.6	4.0	0.8	-0.1	-0.1	-0.7	0.8	0.3	0.4	2.0	0.0	1.1	-0.7	0.1
Impedance of arm (left)	0.6	2.8	6.8	2.5	-2.4	-2.2	1.0	0.1	1.0	-2.1	-0.3	0.9	1.2	-2.6	-1.0
Length of working week for main job	0.6	0.6	2.3	1.2	-0.3	-0.5	1.5	1.1	1.0	0.1	-0.9	0.3	-0.1	0.4	0.7
Peak expiratory flow (PEF)	0.6	1.4	3.0	1.5	-0.2	-0.2	1.7	-1.4	1.3	0.6	-1.6	1.5	1.2	-0.6	0.7
Glaucoma (self-reported)	0.6	0.8	1.8	-1.2	1.3	1.2	-0.1	0.7	-1.0	1.0	1.1	0.4	-0.1	0.9	0.1
Alcohol intake frequency.	0.6	1.3	3.6	-1.2	1.7	1.9	-0.3	-0.0	-0.5	1.5	1.5	0.2	0.4	1.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.5	0.3	-1.1	-1.2	-1.1	1.1	-0.2	-1.0	1.1	-1.2	0.1	0.2	-0.4
Knee pain experienced in last month	0.6	0.9	2.7	-0.9	0.6	0.8	-1.6	-0.0	-1.0	0.5	-0.1	-1.7	-0.9	1.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.6	2.7	0.8	-1.0	-1.0	-0.0	0.5	0.3	-1.0	0.8	0.1	-0.0	-0.7	-1.7
Illnesses of father: Heart disease	0.6	0.8	2.7	-0.3	1.3	0.8	0.7	-0.6	0.7	1.3	-0.6	1.6	-0.2	0.4	0.9
Loneliness, isolation	0.6	0.8	2.1	1.0	-0.7	-0.8	-0.3	-0.5	1.0	-1.0	-1.5	-1.4	0.6	-0.9	0.3
Long-standing illness, disability or infirmity	0.6	0.9	2.7	-0.4	0.4	0.5	-1.6	-1.6	-1.6	0.3	-0.5	-1.1	0.6	0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.6	1.2	-1.6	-1.4	0.3	-1.2	0.3	-1.2	-0.4	0.2	-0.2	-1.6	-1.5
Ever smoked	0.6	1.1	4.3	0.1	-0.3	-0.4	-0.4	-1.3	1.3	-0.8	-1.9	0.0	2.1	-0.2	-0.9
Arm fat-free mass (left)	0.6	2.8	6.5	-2.4	2.5	2.1	-1.1	-0.9	-1.8	2.0	1.0	-1.0	-1.4	1.7	1.1
Depressed Affect (Nagel 2018)	0.5	1.0	3.1	0.5	-0.6	-0.7	-1.7	0.4	-1.0	-1.3	0.7	-1.2	0.1	-1.8	-0.3
Intelligence (Savage-Jansen 2018)	0.5	1.6	6.2	1.4	-0.5	-0.4	2.1	1.0	-0.7	-0.1	-0.6	0.9	-2.5	-1.1	-1.4
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.6	0.5	0.8	0.7	2.1	0.3	-0.9	1.1	-0.1	1.4	-2.1	-0.7	-0.0
Crohns Disease (2012)	0.5	0.8	1.9	0.9	-1.2	-0.8	1.0	-0.2	1.1	-1.4	-1.0	0.5	0.8	-0.0	-0.8
Blood Platelet Count	0.5	6.0	23.1	1.2	0.5	0.3	4.1	-1.4	-1.6	2.7	-1.8	4.8	-1.6	-3.6	-0.3
Medication: Co-codamol	0.5	0.6	2.6	0.1	0.2	-0.2	-0.6	-0.2	-0.1	0.3	1.3	-1.0	1.6	-0.7	1.1
Leg fat-free mass (left)	0.5	2.6	5.9	-1.8	2.0	1.6	-1.3	-1.1	-2.4	1.8	1.3	-1.6	-1.9	1.1	0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.7	-0.8	-0.9	-0.7	-1.0	0.4	-1.0	-1.1	-0.9	-0.5	0.3	-0.2
Leg predicted mass (left)	0.5	2.5	5.9	-1.8	1.9	1.6	-1.4	-1.1	-2.4	1.7	1.3	-1.6	-1.9	0.9	-0.0
Past tobacco smoking	0.5	1.0	3.2	0.7	-0.2	-0.1	0.8	1.8	-0.4	0.2	1.6	0.7	-1.3	-0.5	1.5
Nervous feelings	0.5	1.0	4.3	1.1	-0.3	-0.7	1.4	0.9	2.1	-0.9	-0.6	0.5	0.6	-0.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	3.4	0.5	-0.7	-0.3	-0.2	-1.8	0.2	-0.0	-0.8	-0.2	1.2	0.2	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	3.0	-0.6	0.0	-0.0	-0.3	1.7	-0.4	-0.1	0.2	-0.8	-1.6	0.4	-1.0
Lung cancer (father)	0.5	0.6	1.5	-0.3	-0.5	-0.6	0.5	-1.1	1.2	-1.2	-1.1	-0.3	0.5	1.0	0.0
Birth weight of first child	0.5	0.9	6.6	-0.2	0.1	0.5	0.1	0.5	-0.9	-0.3	-0.7	-0.4	-2.6	0.6	-1.3
Pulse wave reflection index	0.5	0.6	1.6	-0.8	0.7	0.5	-0.4	0.5	0.9	-0.3	-0.4	-0.3	1.0	1.2	1.3
Loud music exposure frequency	0.5	0.6	2.8	-0.0	-0.7	-1.0	-0.1	0.1	0.7	-1.7	-0.1	-1.4	0.3	0.2	-0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.6	0.7	0.1	0.2	1.6	-0.6	0.7	1.4	0.2	1.3	0.5	0.1	0.8
Medication: Amlodipine	0.5	0.8	2.0	-0.7	0.9	0.8	0.1	-0.3	-1.2	1.4	1.3	-0.3	-0.8	0.1	1.1
Arm fat-free mass (right)	0.5	2.5	6.4	-2.2	2.5	2.0	-1.1	-0.5	-1.4	2.0	0.6	-1.0	-1.3	1.6	1.0
Exposure to tobacco smoke outside home	0.5	0.7	2.8	-0.1	0.3	0.1	0.3	-0.3	1.3	0.1	-1.7	1.0	1.7	0.2	0.5
Age at first live birth	0.5	0.9	3.2	1.3	-0.9	-0.7	1.1	0.1	0.3	-0.1	-0.2	1.7	0.2	-1.8	0.3
Emphysema/chronic bronchitis	0.5	0.5	1.5	-1.0	0.9	0.9	0.4	0.8	-0.4	0.3	-0.1	-0.5	-0.8	1.2	0.6
Medication: Allopurinol	0.5	0.7	2.7	0.9	-0.5	-0.9	-0.2	-1.5	-0.8	-0.4	0.1	-0.3	-0.4	-1.6	0.4
Overall health rating	0.5	1.0	3.3	-0.9	0.8	0.6	-1.0	-0.4	-0.8	-0.2	0.4	-1.8	1.1	1.3	1.3
Age at last live birth	0.5	0.7	3.4	1.0	-0.5	-0.5	0.8	0.8	0.0	0.1	1.0	1.1	-0.3	-1.9	0.0
Supplements: Vitamin C	0.5	0.6	2.5	0.0	-0.4	-0.7	0.1	0.8	0.4	-1.1	-1.4	-0.6	-0.5	-0.2	-1.6
Eye problems/disorders: Cataract	0.5	0.6	3.3	-0.7	0.2	0.3	-1.8	0.3	1.0	-0.3	0.4	-0.8	1.1	0.3	-0.2
Breast cancer (self-reported)	0.5	0.6	1.9	1.4	-1.0	-1.2	0.7	-0.3	0.1	-0.6	-0.0	0.0	0.4	-1.0	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	-0.9	0.9	1.2	0.3	-0.5	-0.8	0.9	-0.1	0.2	-0.5	1.1	-1.1
Alcohol drinker status: Never	0.5	0.6	2.9	-0.5	0.6	0.6	0.0	0.2	0.9	0.0	1.7	0.7	1.1	0.5	0.6
Basal metabolic rate	0.5	2.6	5.2	-2.0	2.3	1.8	-0.9	-1.1	-2.2	1.9	1.2	-1.1	-1.8	1.3	0.6
Arm predicted mass (left)	0.5	2.3	5.7	-2.1	2.4	1.9	-1.0	-1.0	-1.5	1.8	1.0	-0.7	-1.0	1.5	1.2
Ulcerative Colitis	0.4	0.6	2.0	-1.0	0.7	0.5	-0.4	-1.2	-0.9	0.3	-0.5	-0.3	-0.4	1.4	0.4
Systolic Blood Pressure	0.4	2.0	7.9	0.1	0.8	1.6	2.8	1.4	0.1	1.9	1.1	0.8	-1.2	0.3	2.0
Sensitivity / hurt feelings	0.4	0.6	2.0	0.9	-0.7	-0.9	0.6	-0.7	0.3	-1.0	0.4	-0.7	0.9	0.1	1.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	-1.0	0.6	0.4	-0.3	-1.1	-0.3	0.1	-0.1	0.6	1.2	0.8	0.6
Townsend deprivation index at recruitment	0.4	0.6	2.3	-0.8	1.0	0.7	-0.7	0.4	1.5	0.3	-0.3	-0.4	1.2	0.3	0.3
Medication: Levothyroxine sodium	0.4	0.7	3.2	0.2	-0.4	-0.1	-0.4	-1.4	0.3	-0.9	0.1	-0.1	1.8	-0.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.9	1.2	-0.4	-0.9	1.4	0.7	1.3	0.2	-0.5	0.1	0.1	-0.4	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.0	0.7	-0.4	-0.5	-0.2	-0.8	0.1	-0.1	-0.6	1.1	0.5	-1.7	-0.1
Health satisfaction	0.4	0.6	1.7	-0.0	-0.4	-0.3	-0.9	-0.9	-0.6	-0.8	-0.9	-0.9	-0.2	-0.8	-1.3
Medication for pain relief, constipation, heartburn	0.4	0.7	3.3	1.3	-0.7	-0.6	0.3	-0.1	0.5	0.1	-1.0	-0.0	0.2	-1.8	-0.8
Arm predicted mass (right)	0.4	2.2	5.9	-1.9	2.4	1.9	-0.7	-0.3	-0.9	2.0	1.0	-0.6	-1.1	1.7	1.3
Family relationship satisfaction	0.4	0.5	1.8	0.3	-0.3	-0.2	0.2	-0.5	0.0	-0.7	-1.3	-1.4	1.2	0.4	0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.7	0.6	-0.0	-0.0	-0.5	-1.6	-0.2	0.0	-1.2	-0.2	0.7	-0.5	0.0
Illnesses of siblings: Diabetes	0.4	0.5	1.7	-0.1	0.7	0.5	-0.5	1.3	0.8	0.9	0.3	0.3	0.6	0.8	0.8
Leg fat-free mass (right)	0.4	2.0	4.5	-1.5	1.8	1.4	-0.8	-0.9	-2.1	1.8	1.5	-1.1	-1.8	0.8	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	2.3	0.5	-0.2	-0.1	1.4	-0.7	-0.6	0.2	-0.4	1.5	0.1	-0.1	0.0
Osteoporosis (self-reported)	0.4	0.4	1.2	-0.4	0.7	1.0	-1.0	-0.1	0.1	0.6	-0.1	-1.0	1.1	0.4	-0.0
Smoking status: Current	0.4	0.6	2.9	0.4	-0.7	-0.6	0.4	1.7	-0.4	-0.9	0.6	0.2	-0.4	-0.8	-1.2
Leg predicted mass (right)	0.4	2.1	4.7	-1.5	1.8	1.4	-0.9	-0.8	-2.2	1.7	1.5	-1.2	-1.8	0.9	0.3
Miserableness	0.4	0.6	1.9	1.1	0.4	0.4	-0.3	1.2	0.2	0.4	1.2	-0.2	0.4	-1.4	0.9
Irritability	0.4	0.6	1.7	0.5	-0.5	-0.7	0.9	-0.3	-0.5	-0.7	-1.2	-1.3	-1.0	0.8	0.4
Supplements: Calcium	0.4	0.4	1.8	0.7	-0.4	0.1	0.0	-0.6	0.7	0.3	-0.9	0.6	0.3	-0.5	-1.3
Schizophrenia (2018)	0.3	0.5	1.5	-0.5	0.4	0.3	1.0	-0.6	1.0	0.1	-0.8	1.2	0.9	-0.4	0.8
Schizophrenia vs Biploar Disorder	0.3	0.5	1.1	1.0	-0.9	-0.8	0.9	-0.1	-0.3	-0.4	-1.1	-0.4	-0.4	-0.6	0.2
Irritable Bowel Disease (IBD)	0.3	0.7	3.0	0.3	-0.8	-0.8	-0.0	1.1	0.3	-1.1	1.7	0.5	0.8	-0.3	-0.9
Ovarian Cancer	0.3	0.4	1.5	0.3	0.5	0.4	1.2	0.9	0.0	0.7	0.8	0.6	0.1	0.1	0.4
Fasting Glucose	0.3	0.4	1.0	-0.2	0.3	0.6	-0.3	0.8	0.9	0.5	0.1	0.9	1.0	-0.5	-0.0
Blood Eosinophil Count	0.3	2.1	7.9	-1.5	0.6	0.2	-2.8	0.4	-0.8	-0.8	-1.0	-2.0	-0.4	2.4	-1.4
Blood White Count	0.3	2.2	10.2	-1.3	1.4	1.4	-1.5	1.2	-0.2	1.0	1.5	0.1	3.2	1.2	1.6
Allergy or Eczema	0.3	0.9	2.9	1.7	-0.7	-0.7	0.9	0.4	-0.8	-0.4	-0.9	0.6	-0.3	-1.7	-1.1
Lung FEV1/FVC ratio	0.3	1.3	6.3	0.8	-1.6	-1.5	-0.6	-1.2	0.8	-2.5	-0.6	-0.5	0.7	-0.4	-0.9
Lung FVC	0.3	1.5	3.9	1.8	-1.4	-1.4	0.7	-0.6	2.0	-1.0	-0.9	1.2	1.2	-0.8	-0.6
Medication for hormone replacement therapy	0.3	0.3	1.5	0.1	-0.1	0.1	-1.1	0.6	-0.8	-0.1	-0.0	-1.2	-0.0	-0.1	-0.1
Severe depression (siblings)	0.3	0.3	1.1	0.2	-0.6	-0.7	-0.8	-0.3	0.2	-1.0	-0.3	0.2	0.2	-0.5	-1.0
Current tobacco smoking	0.3	0.5	1.7	-0.1	-0.6	-0.6	-0.0	1.3	-0.5	-1.0	0.4	-0.0	-0.5	-0.5	-1.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	0.7	-0.7	-0.6	1.1	0.1	-0.1	-0.8	1.0	0.3	0.1	0.6	-0.4
Fluid intelligence score	0.3	0.7	3.5	0.1	0.1	0.0	1.6	0.4	-0.7	-0.2	0.3	0.6	-1.9	-0.8	-0.7
Trunk fat-free mass	0.3	1.5	4.0	-1.2	1.6	1.2	-0.0	-1.1	-1.8	1.7	0.6	-0.2	-2.0	0.7	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.8	0.8	-0.9	-1.1	0.3	-0.2	-0.7	-0.9	0.4	-0.4	-0.1	-1.3	-0.0
Prospective memory result	0.3	0.4	1.4	-0.0	-0.2	-0.4	-0.6	0.1	-0.5	-0.9	1.2	-0.3	-0.0	-1.0	-0.5
Trunk predicted mass	0.3	1.6	3.7	-1.3	1.7	1.3	-0.1	-1.1	-1.8	1.8	0.7	-0.2	-1.9	0.8	0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.9	0.2	-0.5	-0.2	-0.5	-1.2	0.4	-1.1	-0.3	-0.9	1.7	0.5	0.5
Worry too long after embarrassment	0.3	0.4	1.2	0.9	-0.5	-0.7	1.1	0.0	0.9	-0.3	-0.7	-0.2	-0.8	0.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.4	-1.1	0.5	0.7	-0.9	0.5	-0.4	-0.2	0.5	-1.2	0.4	-0.1	0.1
Whole body fat-free mass	0.3	1.8	3.8	-1.4	1.8	1.4	-0.5	-1.0	-1.9	1.8	1.0	-0.6	-1.8	0.9	0.7
Whole body water mass	0.3	2.0	4.1	-1.6	1.9	1.5	-0.7	-1.0	-2.0	1.8	1.1	-0.8	-1.8	0.9	0.6
Ever taken oral contraceptive pill	0.3	0.4	1.2	0.0	0.1	0.1	0.1	-0.2	-1.0	0.2	0.4	0.2	-1.1	-1.1	-0.7
Medication: Paracetamol	0.3	0.4	1.1	-0.8	0.6	0.6	0.0	0.0	-1.0	0.6	0.1	-0.3	-0.9	1.0	0.0
Alcohol drinker status: Previous	0.3	0.3	0.9	0.6	0.5	0.3	0.4	-0.6	0.4	0.9	-0.2	0.3	0.4	-0.6	0.8
Bipolar Disorder (2018)	0.2	0.3	1.2	0.3	0.3	0.5	0.3	0.1	-1.1	0.8	0.6	0.5	-0.7	-0.3	0.2
Neuroticism (Nagel 2018)	0.2	0.4	1.1	1.0	-0.4	-0.6	0.1	0.6	0.8	-1.0	0.2	-0.4	0.4	-0.4	0.9
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	0.5	-0.1	0.3	-0.6	-0.3	0.1	0.7	-0.8	-0.6	-0.9	-0.3	-0.2
Ulcerative Colitis (UC)	0.2	0.4	3.1	-0.3	0.2	-0.1	-0.8	0.6	-0.5	-0.2	1.7	0.1	0.5	-0.0	-0.1
Breast Cancer	0.2	0.4	1.5	0.6	0.0	0.2	1.0	0.5	-0.3	1.1	0.3	1.2	0.0	-0.8	0.5
Schizophrenia (2014)	0.2	0.4	1.7	-0.0	-0.1	-0.3	0.9	-1.3	-0.2	-0.0	-1.1	0.4	-0.7	-0.6	0.2
Smoking Status	0.2	0.4	1.8	-0.3	-0.2	-0.1	-0.4	-0.9	0.6	-0.5	-0.7	-0.4	1.4	0.1	-0.7
Hand grip strength (left)	0.2	0.5	1.8	0.4	-0.3	-0.6	1.4	-0.3	0.2	0.5	-1.1	-0.1	-0.9	0.9	0.1
Systolic blood pressure, automated reading	0.2	0.7	2.3	-0.6	0.3	0.8	-0.2	0.7	-1.2	-0.0	1.0	-1.2	-1.5	0.4	0.4
Pack years adult smoking proportion	0.2	0.3	0.7	0.4	-0.5	-0.8	-0.5	0.4	0.7	-0.6	0.2	-0.7	0.3	0.3	0.7
Hand grip strength (right)	0.2	0.6	1.8	-0.5	0.6	0.4	1.3	-0.6	-0.0	0.9	-0.0	0.3	0.2	1.3	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.3	1.1	-0.7	-0.9	0.5	0.4	0.5	-0.6	-1.0	1.0	0.3	0.1	0.2
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.7	0.9	-0.2	-0.4	0.9	0.4	-0.6	-0.5	-0.7	0.1	-1.3	-0.6	-0.8
Sitting height	0.2	1.1	3.5	0.7	-1.2	-1.6	-0.5	0.1	0.0	-1.9	0.4	-1.4	-0.2	-1.3	-1.0
Allergy	0.2	0.5	1.5	0.5	-0.3	-0.0	0.6	-0.0	1.2	0.7	-0.0	1.2	0.9	-0.2	1.2
Medication: Ramipril	0.2	0.3	2.1	0.3	0.1	0.4	0.0	-0.7	-0.4	0.7	0.4	-0.2	-0.1	-0.2	1.5
Neuroticism score	0.2	0.4	1.2	0.6	-0.2	-0.7	0.2	0.5	0.6	-0.9	0.2	-1.0	0.1	0.0	1.1
Standing height	0.2	1.6	3.9	1.9	-1.4	-1.8	1.7	0.2	0.3	-0.8	0.8	1.2	-1.2	-2.0	-0.1
Tense / ‘highly strung’	0.2	0.3	1.3	0.8	0.2	-0.4	0.2	1.1	0.6	-0.4	-0.6	-0.6	-0.3	0.3	0.6
Medication: Paracetamol	0.2	0.4	1.9	0.0	-0.1	-0.3	0.8	-0.1	0.5	-0.2	-0.7	0.3	-0.0	1.4	0.7
High blood pressure (siblings)	0.2	0.4	1.4	0.1	0.6	0.6	0.2	-0.6	-0.0	1.2	-0.4	0.1	-1.1	0.6	0.2
Medication: Bendroflumethiazide	0.2	0.3	1.1	0.5	-0.5	-0.7	-0.5	-0.3	0.1	-0.6	0.0	-0.1	0.9	-1.0	-0.4
Pack years of smoking	0.2	0.3	1.0	-0.0	-0.0	-0.5	-0.7	0.4	0.3	-0.4	0.5	-1.0	-0.1	0.7	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	1.5	-0.1	0.5	0.5	0.9	-0.2	0.1	0.6	-0.2	1.2	0.2	-0.4	0.7
Lupus	0.1	0.2	1.8	0.0	-0.2	0.2	-0.1	-1.3	-0.4	-0.1	-0.5	0.1	0.3	0.1	-0.1
Heel T-Score	0.1	0.8	2.8	-0.4	1.2	1.0	0.2	0.1	-0.8	1.6	-0.2	1.7	-0.7	0.2	0.8
Height	0.1	2.8	10.3	2.0	-1.2	-1.8	2.1	-0.9	-0.1	0.0	0.6	2.0	-2.1	-3.2	-0.4
Neuroticism	0.1	0.3	1.2	-0.2	0.9	0.3	-0.3	0.2	0.3	0.3	0.6	-0.5	0.3	0.2	1.1
Chronotype (morning person)	0.1	0.3	1.1	-0.0	-0.3	-0.3	-0.2	-1.1	0.1	-0.8	-0.1	-0.4	0.7	0.5	0.9
Hair Pigment	0.1	1.8	9.6	0.2	0.6	0.6	2.3	0.1	0.3	1.4	1.0	3.1	-0.7	-0.3	1.3
Tanning	0.1	0.8	4.2	0.3	0.4	0.5	-2.0	-0.3	-1.2	0.2	-0.2	-0.9	0.0	-1.4	-0.8
Age when periods started (menarche)	0.1	0.3	1.3	0.3	-0.6	-0.8	1.1	0.1	0.8	-0.4	-0.2	-0.1	0.3	0.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	0.7	-0.6	-0.9	0.3	-0.0	0.5	-0.6	-0.9	0.1	0.4	0.7	0.2
Illnesses of siblings	0.1	0.1	0.3	-0.5	-0.0	-0.1	0.5	-0.5	-0.5	-0.5	-0.1	0.1	0.0	-0.6	-0.2
Comparative height size at age 10	0.1	0.5	1.8	-0.0	-0.4	-0.5	-0.5	-1.4	-0.7	-0.6	0.8	-0.5	-1.1	-0.6	-0.8

Hub : Genes

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Models

Trait associations