TWAS hub - EAF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.4940	0.0930	1.5e-08	0.423	NA	0.401	NA	0.425	4.2e-12	NA	2.2e-11	NA	3.6e-12
2	GTEx	Brain Cerebellum	0.2540	0.0700	6.7e-06	0.168	NA	0.192	NA	0.205	1.1e-05	NA	2.5e-06	NA	1.1e-06
3	YFS	Blood	0.0256	0.0106	4.2e-04	0.018	0.007	0.007	0.008	0.009	1.0e-06	2.2e-03	1.3e-03	0.00075	4.9e-04
4	TCGA	Brain Lower Grade Glioma	0.0420	0.0238	4.9e-03	0.021	0.007	-0.002	NA	0.015	1.6e-03	5.3e-02	6.6e-01	NA	7.5e-03
5	TCGA	Prostate Adenocarcinoma	0.0510	0.0245	9.0e-06	0.054	0.037	0.039	NA	0.040	2.4e-06	9.3e-05	5.4e-05	NA	4.3e-05
6	TCGA	Thyroid Carcinoma	0.0700	0.0360	8.7e-04	0.050	0.040	0.051	NA	0.051	1.3e-05	9.0e-05	9.1e-06	NA	1.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Medication: Atenolol	6.9	8.6	12.2	3.3	3.5	-3.5	2.7	1.1	2.9
Medication: Atorvastatin	6.3	7.8	12.5	3.5	3.5	-2.6	1.9	2.4	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.9	7.0	12.2	3.1	3.5	-2.1	2.8	0.0	2.8
Pulse rate, automated reading	4.9	15.9	29.6	4.1	4.2	-3.6	0.6	5.4	4.2
Multivitamins +/- minerals	4.0	5.1	10.8	-3.3	-3.1	1.9	-2.0	-0.8	-1.2
Alcohol usually taken with meals	3.7	6.0	9.6	3.1	2.9	-2.6	1.5	2.1	2.1
Medication for cholesterol	3.5	5.3	9.9	-2.2	-2.2	2.9	-3.1	-0.1	-1.9
Frequency of depressed mood in last 2 weeks	3.2	4.4	11.2	-3.3	-2.8	0.5	-0.7	-1.7	-1.9
Time employed in main current job	2.9	3.3	10.0	-3.2	-2.9	-0.1	1.0	-0.7	-0.1
Heart attack	2.8	3.6	8.0	1.7	1.7	-1.5	2.8	0.7	2.2
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	6.5	-1.8	-1.5	2.5	-2.2	-0.7	-1.6
Heart attack/myocardial infarction (self-reported)	2.7	3.5	7.6	1.8	1.9	-1.3	2.8	0.5	2.2
Ever depressed for a whole week	2.6	3.1	7.4	-2.7	-2.6	1.3	-1.3	0.5	-1.2
Birth weight	2.5	5.4	15.5	-3.5	-3.9	-1.0	0.4	1.1	-1.5
Medication: Aspirin	2.5	3.3	5.1	2.0	1.9	-2.1	1.2	1.1	2.2
Medication: Blood pressure	2.5	4.8	10.7	2.2	2.0	-2.6	3.3	-0.1	1.5
Diverticular disease/diverticulitis (self-reported)	2.4	2.8	5.7	-2.4	-2.0	1.9	-0.9	-0.4	-1.6
Pulse rate	2.4	4.1	12.1	0.9	0.7	-2.1	0.9	3.5	2.5
Chronic bronchitis/emphysema (mother)	2.4	2.8	7.8	2.8	2.7	0.5	-1.0	-0.4	-0.4
Commuting to job workplace: Public transport	2.2	2.6	5.8	0.5	0.4	-1.7	1.7	2.0	2.4
Diastolic blood pressure, automated reading	2.2	6.8	14.1	1.5	1.4	-3.8	1.8	3.1	3.1
Age at First Birth	2.1	3.0	8.1	-2.8	-2.3	1.6	-0.4	-0.8	-1.2
Happiness	2.1	2.6	4.2	-1.4	-1.5	1.8	-1.1	-2.1	-1.6
Myopia	2.1	3.1	4.1	-1.6	-1.7	1.6	-1.9	-1.6	-2.0
Cholesterol lowering medication	2.1	3.1	7.6	2.0	1.7	-2.8	1.6	0.9	0.6
Had menopause	2.0	2.4	4.7	2.1	2.2	-1.4	-0.1	1.8	0.6
Medication: Aspirin	2.0	2.6	4.7	1.6	1.5	-2.2	1.3	0.7	1.9
Waist circumference	1.9	7.0	19.9	4.5	4.3	-0.8	-0.5	0.8	1.3
High cholesterol (Self-reported)	1.9	3.4	11.0	1.8	1.7	-3.3	1.1	0.6	1.3
Taking other prescription medications	1.8	2.8	8.8	2.7	3.0	-0.7	-0.5	0.5	0.4
Chronic bronchitis/emphysema (father)	1.8	2.1	5.8	-1.3	-1.2	0.5	-1.1	-2.4	-1.5
Depression (self-reported)	1.8	2.2	5.0	-2.2	-2.2	1.6	-0.5	-0.5	-0.5
Arm fat percentage (left)	1.8	7.1	20.4	4.5	4.3	-0.1	-1.2	0.4	1.2
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	7.5	2.7	2.7	-1.1	0.9	-0.6	0.7
Back pain experienced in last month	1.8	2.6	5.2	2.3	2.2	-2.1	-0.2	0.5	0.9
Arm fat mass (left)	1.8	7.4	20.2	4.5	4.4	-0.5	-0.4	0.8	2.0
Major Depression (MDD)	1.7	2.0	4.8	0.0	0.4	1.6	-1.2	-1.9	-2.2
Arm fat mass (right)	1.7	7.0	19.3	4.4	4.3	-0.3	-0.2	0.7	1.9
Handedness (chirality/laterality): Left-handed	1.7	2.1	6.8	1.6	1.1	-1.3	2.6	0.3	0.4
Medication: Gliclazide	1.7	1.9	6.2	2.1	2.5	0.1	-0.3	-0.7	0.0
Qualifications: None of the above	1.6	3.4	5.9	2.4	2.3	0.1	-1.4	-2.3	-1.5
Arm fat percentage (right)	1.6	6.4	18.2	4.3	4.2	-0.1	-0.8	0.6	1.3
Medication: Cholesterol lowering	1.6	2.5	4.5	2.0	2.1	-1.8	-0.1	1.5	1.0
Breastfed as a baby	1.6	2.0	3.6	1.9	1.7	-1.8	0.7	0.2	1.3
Medication: Ventolin 100micrograms inhaler	1.6	2.0	3.3	1.6	1.8	-1.8	-0.1	1.7	0.5
Number of children fathered	1.6	1.9	3.8	1.2	1.2	1.0	-2.0	-1.6	-0.9
Unable to work because of sickness or disability	1.6	2.1	3.0	-1.4	-1.3	1.7	-1.6	-0.9	-1.7
Vitamin and mineral supplements	1.5	2.0	4.0	1.6	1.5	-2.0	1.7	0.3	0.4
Body mass index (BMI)	1.5	6.3	17.0	4.1	4.1	-0.2	-0.4	0.7	1.9
Number of full brothers	1.5	1.9	3.3	1.3	1.1	0.7	-1.2	-1.8	-1.8
Leg fat mass (right)	1.5	5.7	16.9	4.1	3.9	-0.2	-0.8	0.4	1.1
Wears glasses or contact lenses	1.5	1.7	3.3	1.2	1.4	-1.6	-0.7	1.8	0.7
Coronary Artery Disease (CAD)	1.4	1.7	4.1	1.5	1.1	-2.0	0.9	0.6	1.3
BMI	1.4	8.0	19.6	4.4	4.4	-1.1	0.6	0.6	2.7
Hearing difficulty/problems: Yes	1.4	2.2	5.6	2.4	2.2	0.6	-1.2	-0.2	-0.9
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	7.2	0.5	0.5	-1.1	0.3	2.7	0.4
Medication: Metformin	1.4	2.0	5.8	1.9	2.4	-1.1	0.2	-0.2	1.0
Supplements: Glucosamine	1.4	1.8	2.9	-1.7	-1.7	1.4	-1.4	0.6	-1.0
Financial difficulties in last 2 years	1.4	1.9	6.6	1.3	1.0	0.6	-2.6	0.2	-1.4
Ever highly irritable/argumentative for 2 days	1.4	1.6	3.3	1.7	1.5	-0.9	-0.4	1.8	0.3
Leg fat percentage (right)	1.4	5.1	15.4	3.9	3.7	-0.2	-1.1	0.2	0.6
Medication for pain relief, constipation, heartburn	1.4	2.4	6.3	-0.8	-1.0	1.7	-2.5	0.0	-1.9
Number of full sisters	1.4	1.7	4.7	1.7	2.2	-0.1	1.1	-0.3	1.0
Leg fat percentage (left)	1.4	4.9	15.4	3.9	3.6	-0.2	-0.7	-0.1	0.6
Leg fat mass (left)	1.4	5.5	16.3	4.0	3.8	-0.3	-0.4	0.4	1.3
Depression (Nagel 2018)	1.3	2.0	3.7	-1.9	-1.8	0.1	-0.7	-1.4	-1.7
HDL Cholesterol	1.3	2.1	7.2	-1.4	-1.3	-0.7	2.7	-1.1	0.6
LDL Cholesterol	1.3	2.1	3.4	1.8	1.8	-1.5	0.5	1.8	0.5
Primary Biliary Cirrhosis	1.3	1.9	4.8	1.4	1.1	-1.8	0.2	2.2	0.4
Systolic Blood Pressure	1.3	6.3	13.7	1.1	1.1	-3.0	3.7	2.1	2.8
Relative age of first facial hair	1.3	2.7	6.1	-2.1	-2.0	2.5	-0.6	-1.0	-0.5
Hip circumference	1.3	5.5	12.9	3.5	3.6	-0.3	-1.0	1.9	1.7
Body fat percentage	1.3	5.1	15.8	4.0	3.7	-0.0	-1.0	-0.2	0.3
Mouth/teeth dental problems: Loose teeth	1.3	1.6	1.9	1.3	1.4	-1.3	-0.5	1.3	1.4
Ever smoked	1.3	2.3	5.2	-0.0	-0.8	1.1	-2.0	-2.3	-1.5
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.9	2.2	2.4	-1.1	0.9	-0.8	-0.6
Number of treatments/medications taken	1.2	2.2	3.8	1.3	1.9	-1.9	0.4	1.3	1.5
Alcohol intake versus 10 years previously	1.2	1.8	4.7	2.0	2.2	-0.2	1.0	0.2	0.8
Number of live births	1.2	1.7	4.2	1.9	2.0	-0.4	0.4	1.1	1.0
Medication: Blood pressure	1.2	2.1	5.2	2.1	2.3	-0.9	0.6	1.0	0.8
Whole body fat mass	1.2	5.1	15.0	3.9	3.7	-0.2	-0.8	0.3	1.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.6	-1.1	-1.1	-1.4	1.6	1.4	0.3
Average weekly red wine intake	1.2	1.7	4.3	1.7	1.7	-2.1	-0.5	0.1	-0.4
Diabetes diagnosed by doctor	1.2	2.0	5.6	2.1	2.4	-1.2	0.6	-0.4	-0.6
Qualifications: nursing, teaching	1.2	1.9	5.3	-0.6	-0.5	-1.8	2.3	1.1	1.2
Cardiovascular Disease	1.1	3.6	5.4	2.3	2.3	-2.2	1.9	0.5	1.5
Medication: Co-codamol	1.1	1.3	4.0	-0.1	0.4	0.4	-0.8	-2.0	-1.6
Diabetes (mother)	1.1	1.4	4.0	2.0	1.5	-0.3	-0.5	-1.2	-0.2
Trunk fat percentage	1.1	4.6	14.3	3.8	3.5	-0.1	-0.9	-0.3	0.3
Trunk fat mass	1.1	4.9	15.0	3.9	3.6	-0.1	-0.7	0.1	0.9
Hearing difficulty/problems with background noise	1.1	1.8	3.2	1.3	1.0	1.0	-0.9	-1.8	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	8.4	-2.7	-2.9	0.5	-0.0	-1.9	-1.1
Exposure to tobacco smoke at home	1.1	1.3	3.1	1.5	1.5	0.1	-1.8	0.4	-0.3
Gout (self-reported)	1.1	1.6	3.9	-2.0	-1.6	1.2	0.5	-0.6	-0.9
Had major operations	1.1	1.3	2.7	1.4	1.6	-0.4	-0.2	1.6	0.7
Breast cancer (self-reported)	1.1	1.3	2.7	-0.9	-1.0	1.6	-1.6	-0.4	-0.8
Commuting to job workplace: Cycle	1.1	1.3	4.6	0.8	0.9	0.9	-0.6	-2.1	-0.7
Impedance of whole body	1.1	5.5	11.1	-3.0	-3.3	1.1	-0.7	-1.7	-3.0
Bipolar Disorder (2011)	1.0	1.0	2.1	-1.2	-0.9	0.7	0.8	0.4	1.5
Triglycerides	1.0	1.7	4.0	1.0	1.6	1.1	-2.0	0.3	-1.2
Fed-up feelings	1.0	1.8	5.5	-2.3	-2.1	-0.2	0.2	-0.9	0.1
Impedance of leg (left)	1.0	4.8	9.2	-2.7	-3.0	0.5	0.9	-2.2	-2.6
Pain all over the body in last month	1.0	1.1	1.9	1.4	1.3	0.9	0.9	-0.8	0.7
Qualifications: A levels/AS levels or equivalent	1.0	2.1	5.2	-0.8	-1.2	-0.5	0.8	2.3	2.1
Glaucoma (self-reported)	1.0	1.2	2.8	1.4	1.7	-0.3	0.4	0.3	1.4
Angina (self-reported)	1.0	1.4	3.8	2.0	1.6	-0.7	0.8	-0.8	-0.4
Medication: Seretide 50 evohaler	1.0	1.2	2.8	0.1	0.3	1.4	-0.9	-1.3	-1.7
Financial situation satisfaction	1.0	1.2	2.9	-1.7	-1.5	1.1	0.6	0.1	0.9
Risk taking	1.0	1.4	3.6	-0.5	-0.1	1.9	-1.0	-1.7	-1.0
Vascular/heart problems diagnosed by doctor	1.0	2.7	5.0	-2.2	-2.0	1.7	-1.8	-0.5	-1.1
Pain experienced in last month	1.0	1.7	4.2	-2.0	-2.0	0.8	-0.3	-0.2	-1.0
HbA1C	0.9	1.0	5.6	-0.2	0.0	-0.3	-0.3	2.4	0.3
Impedance of leg (right)	0.9	4.1	8.2	-2.6	-2.9	0.4	0.2	-1.7	-2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	4.0	-1.1	-0.9	-0.1	-0.3	-2.0	-1.0
Had other major operations	0.9	1.1	2.9	1.7	1.3	-0.6	-1.3	0.2	0.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.3	5.8	0.4	0.5	-0.5	-0.8	2.4	0.6
Medication: Simvastatin	0.9	1.3	2.7	1.6	1.6	-1.4	-0.2	0.5	0.2
Weight	0.9	4.5	11.6	3.4	3.3	-0.3	-0.3	1.0	1.8
Falls in the last year	0.9	1.2	1.8	1.4	1.2	-1.3	-1.4	0.1	-0.5
Birth weight of first child	0.9	1.7	6.2	0.4	-0.0	-1.4	1.0	2.5	0.8
Headache pain in last month	0.9	1.6	3.0	1.1	1.6	-0.6	1.7	0.3	1.5
Leg pain on walking	0.9	1.2	2.9	1.0	0.7	-1.7	0.3	1.5	0.6
Hypertension (Self-reported)	0.9	2.5	3.8	2.0	1.8	-1.4	1.9	0.9	1.2
Ever had bowel cancer screening	0.9	1.0	3.7	1.0	0.8	-0.2	-1.9	0.7	0.4
Illnesses of father: None of the above (group 1)	0.9	1.1	3.4	0.9	0.9	0.6	0.0	1.1	1.9
Average weekly champagne plus white wine intake	0.9	1.2	3.6	-0.8	-0.8	-0.5	1.2	0.9	1.9
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.0	-1.4	-1.2	0.8	-1.4	0.2	-0.9
Average weekly beer plus cider intake	0.9	1.3	4.0	-1.4	-2.0	0.9	0.1	-1.1	-0.1
Heart disease (siblings)	0.9	1.1	2.5	1.6	1.5	-1.0	0.6	0.6	-0.2
Alzheimer’s Disease (in father)	0.8	0.8	2.0	-0.7	-0.7	-0.7	1.2	1.4	0.0
Prostate Cancer	0.8	1.1	2.1	1.1	1.2	0.7	1.0	-1.5	-0.6
Body Mass Index (BMI) (2010)	0.8	1.1	1.6	1.2	1.3	-0.2	-1.3	0.9	1.1
Rheumatoid Arthritis	0.8	1.1	2.8	1.7	1.2	0.6	-0.1	-1.0	-1.1
Blood Red Count	0.8	8.2	14.6	3.8	3.7	-1.4	1.9	2.6	3.0
Hypothyroidism (self reported)	0.8	1.7	3.1	-1.4	-1.2	-0.1	1.8	-1.8	1.0
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.2	1.5	1.4	-1.0	-0.8	0.5	-0.2
Ever had hysterectomy (womb removed)	0.8	0.9	1.7	-0.4	-0.8	-1.0	0.7	1.2	1.3
Angina	0.8	1.1	2.7	1.6	1.3	-0.8	0.8	-0.8	-0.4
Townsend deprivation index at recruitment	0.8	1.1	3.8	0.9	0.4	-1.0	-0.6	-2.0	-0.5
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	-0.8	-0.9	-0.8	1.4	0.0	1.2
High blood pressure	0.8	2.3	3.8	1.9	1.9	-1.3	1.9	0.5	1.0
Past tobacco smoking	0.8	1.4	4.5	-0.4	0.4	-1.0	2.1	1.5	0.7
Impedance of arm (right)	0.8	3.9	10.0	-2.9	-3.2	0.3	-0.4	-0.4	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.1	-0.6	-0.3	0.9	-1.5	-0.7	-1.1
Asthma	0.8	1.6	4.1	1.8	2.0	-0.1	-1.1	1.0	-0.0
Illnesses of mother	0.8	1.0	3.8	0.6	1.0	0.7	-2.0	0.5	-0.3
High blood pressure (siblings)	0.8	1.1	3.1	0.8	0.3	-1.2	1.0	0.8	1.8
Forced vital capacity (FVC), Best measure	0.8	2.8	6.5	-2.3	-2.6	0.4	0.1	-2.0	-1.0
Heart disease (mother)	0.8	1.0	2.2	-1.1	-1.5	-0.3	1.2	-0.6	-0.8
Guilty feelings	0.8	1.3	3.5	-1.4	-1.2	0.2	0.3	-1.9	-0.9
Medication: Paracetamol	0.8	1.2	2.6	0.9	0.9	-1.6	1.0	0.6	1.3
Medication: Lisinopril	0.8	1.1	2.7	0.8	0.8	-0.2	1.6	-0.3	1.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.0	1.1	1.0	-0.7	-0.7	1.4	0.3
Bipolar Disorder (2018)	0.7	1.1	3.3	0.0	0.4	0.9	0.6	1.3	1.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.0	0.8	0.2	0.9	-1.4	-0.9	0.5
Respiratory disease	0.7	1.5	3.6	1.5	1.9	0.8	-0.6	1.0	1.1
Average weekly spirits intake	0.7	0.9	1.3	1.0	1.0	1.1	0.9	-0.7	1.1
Systolic blood pressure, automated reading	0.7	2.1	3.9	0.6	0.6	-1.5	2.0	1.9	1.5
Supplements: Zinc	0.7	0.8	1.8	-0.4	-0.9	1.4	-1.0	-0.8	0.5
Diabetes (father)	0.7	0.8	1.6	-0.9	-0.5	1.2	0.1	-1.2	-0.9
Maternal smoking around birth	0.7	1.0	3.6	0.7	0.2	1.0	-1.9	0.4	-0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.8	1.7	0.7	-0.2	-0.4	-0.9	-0.4
Serious illness, injury or assault to yourself	0.7	0.9	2.0	1.2	1.4	0.1	0.0	1.1	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.7	-1.0	-0.7	-1.1	-0.4	-1.3	-1.3
Mouth/teeth dental problems	0.7	1.1	2.2	-1.4	-1.5	1.1	-0.7	0.1	-0.9
Hair/balding pattern: Pattern 3	0.7	1.0	2.1	1.4	1.3	-0.6	0.1	-0.8	-1.0
Impedance of arm (left)	0.7	3.2	6.6	-2.3	-2.6	0.6	-1.1	-0.7	-2.3
Exposure to tobacco smoke outside home	0.7	0.9	2.9	0.1	-0.1	0.9	-0.7	-1.7	-1.2
Migraine (self-reported)	0.7	0.9	2.4	-1.6	-1.1	0.1	0.3	0.3	1.3
Suffer from ‘nerves’	0.7	1.1	5.2	0.4	0.1	-0.5	0.7	-2.3	-0.7
Smoking status: Previous	0.7	1.1	3.2	0.5	-0.1	0.4	-1.8	-1.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.5	-1.9	-2.1	0.1	0.1	-0.9	-0.4
Loneliness, isolation	0.7	0.9	1.9	-1.0	-1.3	-0.2	-0.1	-1.0	-1.4
Mineral and other dietary supplements	0.7	0.9	2.1	0.8	0.6	-0.6	1.4	0.6	1.2
Asthma (self-reported)	0.7	1.3	3.5	1.6	1.9	0.1	-1.0	0.8	0.0
Illnesses of father: High blood pressure	0.7	0.8	2.2	-0.1	-0.0	-1.5	0.5	-0.5	-1.5
Arm fat-free mass (left)	0.7	3.3	7.2	2.5	2.7	-0.4	0.9	0.8	2.2
Supplements: Calcium	0.7	0.8	3.6	-0.4	-0.6	-0.4	0.4	0.3	1.9
Schizophrenia vs Biploar Disorder	0.6	0.8	2.5	-0.9	-0.9	-0.6	0.1	0.6	-1.6
Alzheimer’s Disease (in mother)	0.6	0.7	2.0	0.5	0.6	-1.0	-1.4	0.6	0.2
Crohns Disease (2017)	0.6	1.4	4.4	-1.5	-1.0	2.1	-0.3	-0.3	0.7
Crohns Disease (2012)	0.6	1.0	3.2	-1.2	-1.0	1.8	0.1	0.3	0.7
Blood White Count	0.6	4.4	15.6	1.2	1.6	4.0	-1.1	-2.2	-1.1
Qualifications: CSEs or equivalent	0.6	0.8	3.8	-0.7	-0.5	2.0	0.4	-0.3	0.5
High blood pressure (mother)	0.6	0.8	2.6	-0.6	-0.8	-0.6	1.6	-0.8	0.3
Hair/balding pattern: Pattern 2	0.6	0.8	3.0	-0.5	-0.7	-0.5	0.9	-0.1	1.7
Diabetes (self-reported)	0.6	1.0	2.0	1.4	1.4	-1.1	0.6	-0.3	-0.8
Medication: Ramipril	0.6	0.8	2.4	0.1	0.1	-1.6	0.7	0.1	-1.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.9	-2.0	-2.2	0.4	-0.1	-1.6	-1.0
Mouth/teeth dental problems: Dentures	0.6	1.1	2.5	0.8	1.0	-1.6	0.3	0.5	1.4
Medication: Lansoprazole	0.6	0.7	2.0	-0.5	0.1	0.4	-1.4	-1.1	-0.8
Length of working week for main job	0.6	0.7	2.1	-0.5	-0.6	-0.3	1.4	-0.3	1.0
Pulse wave reflection index	0.6	0.7	2.0	0.6	0.6	0.3	0.7	-1.4	-1.1
Arm fat-free mass (right)	0.6	2.9	6.7	2.5	2.6	-0.3	0.5	0.5	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.3	-1.3	-1.5	0.8	0.4	0.1	0.2
Emphysema/chronic bronchitis	0.6	0.7	1.0	0.8	0.8	-0.9	1.0	0.9	0.3
Arm predicted mass (right)	0.6	2.9	6.1	2.3	2.5	-0.4	0.9	0.4	2.1
Alcohol intake frequency.	0.6	1.4	3.0	1.6	1.7	-0.3	0.7	0.3	1.4
Chest pain or discomfort	0.6	0.9	1.9	0.9	0.6	0.2	0.7	1.3	1.4
Family relationship satisfaction	0.6	0.7	1.6	-0.5	-0.6	1.1	-0.5	-0.9	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.7	-1.0	-1.1	-0.1	0.7	0.0	1.3
Friendships satisfaction	0.6	0.7	2.0	0.1	-0.2	0.6	-0.2	-1.4	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.8	-1.7	-1.3	0.3	-1.3	0.1	-1.0
Number of self-reported non-cancer illnesses	0.6	1.1	2.0	1.2	1.4	-1.2	-0.0	0.8	1.0
Basal metabolic rate	0.6	3.1	6.1	2.3	2.5	-0.3	0.4	1.3	2.3
Number of operations (self-reported)	0.6	0.9	2.6	0.9	0.9	-0.3	-1.0	1.6	0.3
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	-1.1	-1.0	-0.8	1.2	0.2	0.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.1	-0.8	-1.1	-0.2	0.6	-1.0	1.0
Arm predicted mass (left)	0.6	2.8	6.3	2.4	2.5	-0.1	0.8	0.6	2.0
Worry (Nagel 2018)	0.5	1.0	3.4	0.7	0.3	-0.0	0.1	-1.8	-1.4
Reaction Time	0.5	1.0	3.7	-0.7	-0.9	-0.3	-0.7	1.9	-0.4
Verbal and Numeric Reasoning (VNR)	0.5	1.1	3.7	0.9	0.7	-1.3	-0.0	1.9	-0.4
Pack years adult smoking proportion	0.5	0.8	2.4	-0.6	-0.6	0.1	1.6	-0.6	1.0
Leg fat-free mass (left)	0.5	2.6	4.9	2.0	2.2	-0.2	-0.1	1.3	2.2
Relative age voice broke	0.5	0.8	2.5	0.8	0.9	0.1	0.1	1.6	1.0
Medication: Levothyroxine sodium	0.5	0.9	2.7	-0.7	-0.2	-0.7	1.6	-1.2	0.5
Leg predicted mass (left)	0.5	2.4	4.5	1.9	2.1	-0.1	-0.2	1.4	2.1
Number of incorrect matches in round	0.5	0.9	2.8	1.0	1.0	-0.8	1.7	0.1	0.2
Trunk fat-free mass	0.5	2.6	5.6	1.7	1.9	-0.6	0.9	1.5	2.4
Noisy workplace	0.5	0.7	1.8	-0.5	-0.6	-0.4	-0.2	1.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.1	0.1	0.1	-0.7	0.3	1.1	1.5
Lung cancer (father)	0.5	0.6	1.4	-0.4	-0.7	-1.2	0.2	-1.1	-0.5
Trunk predicted mass	0.5	2.6	5.5	1.8	2.0	-0.5	0.9	1.4	2.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.9	-0.9	-0.7	0.4	0.4	1.4	1.0
Blood clot in the leg (DVT)	0.5	0.7	1.2	-1.0	-1.1	-0.1	0.5	-1.0	0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.6	-1.4	-1.6	0.5	0.3	-0.1	0.1
Medication: Amlodipine	0.5	0.6	1.6	0.9	1.3	-0.8	0.4	0.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.6	0.8	0.5	-1.0	-0.1	1.2	0.3
Shortness of breath walking on level ground	0.5	0.6	1.9	1.4	1.0	0.5	0.3	0.5	-0.0
Eye problems/disorders: None of the above	0.5	0.6	1.5	-1.2	-1.2	0.4	0.4	-0.5	0.0
Mean time to correctly identify matches	0.5	0.9	3.3	0.4	0.1	-1.1	-0.6	1.8	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.6	-1.0	-1.3	0.5	-0.8	0.3	-0.2
Whole body fat-free mass	0.5	2.8	6.2	1.9	2.1	-0.4	0.7	1.4	2.5
Commuting to job workplace: Walk	0.5	0.6	1.3	0.6	0.9	-1.1	-1.0	-0.2	0.2
Osteoarthritis (self-reported)	0.5	0.6	2.5	-0.4	-0.6	-0.3	-0.7	1.6	-0.2
Whole body water mass	0.5	2.7	5.8	1.9	2.2	-0.3	0.6	1.3	2.4
Hearing aid user	0.5	0.5	1.2	1.1	0.9	-0.7	-0.1	0.2	0.8
Mother’s age at death	0.5	0.6	1.2	-1.1	-0.7	-0.6	1.1	-0.6	0.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	1.1	1.3	0.7	-0.5	-0.0	0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.9	1.4	1.2	-0.3	0.0	-0.5	-0.4
Irritability	0.5	0.8	2.4	-0.5	-0.6	-0.7	1.6	0.9	0.8
Alzheimer’s Disease (including proxy)	0.4	0.6	2.6	0.0	0.1	-1.6	0.1	0.8	0.3
Irritable Bowel Disease (IBD)	0.4	1.0	4.5	-0.8	-0.6	2.1	-0.5	0.0	0.5
Waist Hip Ratio (WHR)	0.4	1.9	5.4	2.3	2.0	-1.4	0.2	-0.3	0.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	0.3	0.7	0.9	-0.3	-1.0	-0.7
Severe depression (siblings)	0.4	0.5	1.8	-0.7	-0.6	1.4	0.1	-0.3	0.2
Hand grip strength (right)	0.4	1.0	2.6	0.8	0.8	-0.9	1.6	-0.4	1.1
Nervous feelings	0.4	0.7	1.5	-0.4	-0.9	-0.5	0.3	-1.2	-1.2
Forced vital capacity (FVC)	0.4	1.6	3.3	-1.6	-1.8	0.3	-0.5	-1.6	-1.1
Worrier / anxious feelings	0.4	0.7	1.6	-1.1	-1.2	0.2	0.2	-0.3	-1.3
Loud music exposure frequency	0.4	0.4	0.7	-0.8	-0.8	-0.0	0.6	-0.6	-0.7
Medication: Paracetamol	0.4	0.6	2.4	0.2	0.1	-0.9	1.6	-0.1	0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.6	-0.6	-0.4	-0.1	1.3	-1.3	0.8
Comparative body size at age 10	0.4	1.2	2.0	-1.3	-1.4	1.2	0.3	-1.3	-0.0
Worry too long after embarrassment	0.4	0.7	2.0	-0.7	-0.7	-0.9	1.4	0.3	0.8
Medication: Ibuprofen	0.4	0.4	0.9	0.5	0.3	-0.7	-0.1	0.9	0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.0	-0.2	-0.3	1.4	-0.5	-0.4	-0.5
Illnesses of father: Heart disease	0.4	0.5	1.1	1.1	1.1	-0.6	-0.2	-0.7	-0.3
Leg fat-free mass (right)	0.4	2.3	4.7	1.8	2.0	-0.2	0.2	1.3	2.2
Mood swings	0.4	0.6	1.8	-1.3	-1.2	-0.6	-0.0	0.1	0.5
Osteoporosis (self-reported)	0.4	0.5	1.4	0.7	0.4	0.1	-0.8	-0.7	-1.2
Leg predicted mass (right)	0.4	2.3	4.5	1.9	2.0	-0.2	0.2	1.3	2.1
Fractured/broken bones in last 5 years	0.4	0.5	1.7	0.6	0.5	0.5	-1.3	0.8	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.8	-0.4	0.0	-0.2	0.1	1.4	-0.9
Alcohol drinker status: Previous	0.4	0.4	0.7	0.5	0.2	-0.9	-0.6	-0.8	-0.7
Pack years of smoking	0.4	0.5	2.2	-0.2	-0.2	-0.3	1.5	-0.3	0.8
Intelligence (Savage-Jansen 2018)	0.3	1.0	5.6	-0.3	-0.6	-0.5	-0.3	2.4	-0.1
Ulcerative Colitis (UC)	0.3	0.6	2.8	0.1	-0.0	1.7	-0.7	-0.1	-0.3
Fasting Glucose	0.3	0.4	1.1	0.2	0.2	0.6	-1.0	-1.0	-0.1
Lupus	0.3	0.4	1.9	0.1	-0.4	-0.4	0.6	0.3	1.4
Ulcerative Colitis	0.3	0.4	0.8	0.7	0.6	0.9	0.6	0.8	-0.0
Allergy or Eczema	0.3	0.9	1.9	-0.5	-1.0	1.1	-1.4	0.7	-0.8
Lung FVC	0.3	1.3	2.6	-1.4	-1.6	0.3	-0.8	-1.4	-0.8
Hand grip strength (left)	0.3	0.8	1.9	0.0	-0.3	-1.1	1.3	0.4	1.4
Average weekly fortified wine intake	0.3	0.3	0.6	0.7	0.5	-0.1	-0.4	0.6	0.8
Fluid intelligence score	0.3	0.7	3.1	0.2	0.3	-0.8	0.2	1.8	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.7	-0.5	-0.4	0.8	-0.6	-0.6	-0.8
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	1.0	1.3	-1.3	0.2	0.4	-0.6
Age at first live birth	0.3	0.5	0.8	-0.9	-0.8	0.8	0.3	0.4	-0.6
Neck or shoulder pain in last month	0.3	0.5	1.0	-0.7	-0.8	0.3	-1.0	-0.5	-0.5
Medication: Omeprazole	0.3	0.3	1.1	0.0	0.3	0.2	-0.3	0.8	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.2	0.5	0.6	-1.1	-0.2	-0.2	-0.5
Overall health rating	0.3	0.5	1.2	0.5	0.8	0.7	0.6	-1.1	0.6
Age at last live birth	0.3	0.4	0.6	-0.6	-0.4	0.2	0.7	0.7	0.8
Supplements: Vitamin C	0.3	0.4	1.3	-0.4	-0.5	1.1	-0.5	0.2	0.7
Illnesses of siblings: Diabetes	0.3	0.4	1.6	0.3	0.6	1.3	0.0	-0.6	0.3
Long-standing illness, disability or infirmity	0.3	0.5	1.5	0.2	0.5	1.2	-0.7	-0.3	-0.6
Smoking status: Current	0.3	0.4	0.8	-0.4	-0.4	0.8	-0.0	0.9	0.9
Age started oral contraceptive pill	0.3	0.4	1.4	-0.4	-0.5	0.1	0.7	1.2	-0.2
Depressed Affect (Nagel 2018)	0.2	0.3	0.7	-0.6	-0.4	-0.3	-0.8	-0.5	-0.7
Mean Putamen Volume	0.2	0.3	1.0	-0.1	0.4	-0.3	1.0	0.6	-0.1
Neuroticism (2016)	0.2	0.2	0.7	-0.2	-0.1	-0.3	0.7	-0.8	0.2
Smoking Status	0.2	0.6	1.3	0.0	-0.3	0.9	-1.1	-1.2	-0.0
Lung FEV1/FVC ratio	0.2	1.2	2.4	-1.3	-1.5	1.5	0.2	-0.3	0.7
Neuroticism	0.2	0.5	1.3	0.6	0.9	-0.4	-0.3	-1.1	-0.5
Chronotype (morning person)	0.2	0.4	1.4	-0.5	0.0	0.7	-0.2	-0.5	-1.2
Sensitivity / hurt feelings	0.2	0.4	0.9	-0.8	-0.3	-0.4	1.0	-0.9	-0.1
Medication for hormone replacement therapy	0.2	0.2	1.0	-0.3	0.0	-0.7	0.0	-0.0	1.0
Current tobacco smoking	0.2	0.4	1.0	-0.2	-0.3	0.6	0.1	0.8	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	-0.9	-0.9	0.7	0.2	-0.2	-0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.5	-0.0	-0.6	-0.5	-0.2	1.2	0.3
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.0	0.4	0.5	-0.7	-0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.4	-0.7	-0.8	0.5	-0.4	-0.7	-1.2
Illnesses of siblings	0.2	0.3	1.1	-0.0	0.3	0.1	-0.9	-0.3	-1.1
Neuroticism score	0.2	0.4	1.0	-0.4	-0.3	-0.8	0.6	-1.0	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	-1.0	-0.6	-0.6	0.1	-0.3	0.1
Prospective memory result	0.2	0.2	0.6	-0.5	-0.1	0.8	-0.5	0.2	-0.1
Pulse wave Arterial Stiffness index	0.2	0.3	0.9	-0.6	-1.0	0.3	-0.1	0.4	-0.1
Peak expiratory flow (PEF)	0.2	0.4	1.4	-0.5	-0.5	-0.5	-0.0	-1.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.9	0.1	0.3	0.9	-0.2	-0.3	-0.3
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	1.0	0.7	-0.4	-0.2	0.7	0.2
Pulse wave peak to peak time	0.2	0.2	0.8	0.5	0.9	-0.3	0.2	-0.4	0.3
Medication: Allopurinol	0.2	0.3	1.1	-0.8	-0.2	0.2	-0.3	-0.1	-1.0
Knee pain experienced in last month	0.2	0.4	0.7	0.7	0.8	0.2	-0.8	0.4	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.2	-0.1	0.4	0.1	0.4	0.9
Eye problems/disorders: Cataract	0.2	0.2	1.1	-0.1	0.0	-0.3	-0.2	-1.0	-0.1
Ever taken oral contraceptive pill	0.2	0.2	0.9	0.1	0.1	-0.1	-0.3	0.9	0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.3	0.3	-0.4	0.6	-0.7	-0.0
Medication: Bendroflumethiazide	0.2	0.4	0.8	-0.5	-0.7	-0.2	-0.5	-0.9	-0.5
Alcohol drinker status: Never	0.2	0.3	0.5	0.3	0.7	-0.0	0.4	-0.5	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.8	0.3	0.6	0.6	0.5	0.1	0.9
Neuroticism (Nagel 2018)	0.1	0.3	0.4	-0.6	-0.5	-0.4	0.5	-0.7	-0.5
Schizophrenia (2018)	0.1	0.2	0.9	0.4	0.4	0.1	0.1	-0.9	-0.3
Breast Cancer	0.1	0.3	1.0	0.0	-0.1	0.4	-0.6	0.3	-1.0
Ovarian Cancer	0.1	0.1	0.3	0.4	0.2	0.3	-0.1	0.0	0.5
Schizophrenia (2014)	0.1	0.2	0.6	-0.2	0.1	-0.8	0.6	0.4	-0.1
Blood Eosinophil Count	0.1	0.7	2.8	0.6	0.3	1.7	-0.3	0.0	1.1
Blood Platelet Count	0.1	1.3	3.5	0.8	0.4	0.6	-1.6	1.9	-0.8
Heel T-Score	0.1	0.5	1.5	1.2	0.9	-0.4	-0.2	0.5	-0.1
Hair Pigment	0.1	2.9	7.1	0.7	0.8	-1.8	2.3	0.9	2.7
Age when periods started (menarche)	0.1	0.3	0.8	-0.3	-0.5	-0.0	0.1	-0.9	-0.9
Sitting height	0.1	0.7	1.3	-1.1	-1.0	0.4	-1.1	-0.6	-0.6
Allergy	0.1	0.3	0.7	-0.4	0.0	0.3	0.8	-0.8	-0.4
Father’s age at death	0.1	0.2	0.4	0.5	0.6	0.1	-0.6	-0.0	-0.2
Standing height	0.1	0.6	1.3	-1.1	-1.1	-0.2	0.5	0.8	0.4
Tense / ‘highly strung’	0.1	0.1	0.2	-0.3	-0.4	-0.5	0.4	-0.4	-0.3
Health satisfaction	0.1	0.1	0.4	-0.3	-0.6	0.3	-0.4	0.1	0.3
Qualifications: College or University degree	0.1	0.4	1.3	-1.1	-0.6	-0.3	0.7	0.4	0.3
Comparative height size at age 10	0.1	0.3	0.9	-0.3	-0.1	-0.4	0.2	0.9	1.0
Miserableness	0.1	0.2	0.4	0.1	0.1	-0.7	-0.3	-0.6	-0.1
Height	0.0	0.9	1.9	-1.0	-1.0	-1.2	-0.2	1.4	-0.2
Tanning	0.0	0.6	2.3	0.3	-0.0	-0.2	-1.5	-0.3	-1.1

Hub : Genes

EAF1

Models

Trait associations