Hub : Genes

METTL6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1090 0.0474 4.8e-03 0.033 NA 0.019 NA 0.043 1.2e-03 NA 1.1e-02 NA 2.6e-04
2 GTEx Brain Cerebellar Hemisphere 0.4070 0.1060 8.1e-04 0.061 NA 0.197 NA 0.040 1.2e-02 NA 8.8e-06 NA 3.4e-02
3 GTEx Brain Cerebellum 0.2900 0.1070 3.2e-03 0.152 NA 0.069 NA 0.106 3.0e-05 NA 4.3e-03 NA 4.8e-04
4 GTEx Cells Transformed fibroblasts 0.1960 0.0510 1.6e-07 0.099 NA 0.121 NA 0.138 7.0e-08 NA 2.2e-09 NA 1.7e-10
5 GTEx Esophagus Muscularis 0.1670 0.0630 3.0e-03 0.093 NA 0.034 NA 0.086 2.9e-06 NA 3.5e-03 NA 6.9e-06
6 GTEx Skin Not Sun Exposed Suprapubic 0.2480 0.0760 1.7e-03 0.047 NA 0.178 NA 0.174 1.4e-03 NA 4.7e-10 NA 7.5e-10
7 GTEx Skin Sun Exposed Lower leg 0.1450 0.0520 1.7e-03 0.122 NA 0.077 NA 0.113 2.6e-10 NA 6.5e-07 NA 1.4e-09
8 GTEx Whole Blood 0.1340 0.0430 7.7e-04 0.002 NA -0.002 NA -0.002 1.8e-01 NA 5.5e-01 NA 5.2e-01
9 YFS Blood 0.0350 0.0137 3.7e-04 0.003 0.009 0.010 0.01 0.004 4.1e-02 3.4e-04 2.0e-04 0.00023 1.5e-02
10 TCGA Colon Adenocarcinoma 0.2290 0.0740 5.4e-05 0.017 0.110 0.094 NA 0.043 3.4e-02 6.7e-07 4.5e-06 NA 1.7e-03
11 TCGA Head and Neck Squamous Cell Carcinoma 0.0415 0.0229 7.7e-04 0.004 0.023 0.000 NA 0.012 9.3e-02 1.0e-03 2.7e-01 NA 1.5e-02
12 TCGA Brain Lower Grade Glioma 0.0475 0.0284 7.7e-03 0.008 0.009 0.002 NA 0.004 4.0e-02 3.1e-02 1.7e-01 NA 1.2e-01
13 TCGA Lung Squamous Cell Carcinoma 0.0508 0.0264 5.5e-03 -0.002 0.001 -0.002 NA -0.002 6.9e-01 2.1e-01 1.0e+00 NA 6.1e-01
14 TCGA Prostate Adenocarcinoma 0.0447 0.0254 1.9e-03 0.023 0.018 0.004 NA 0.018 1.7e-03 5.2e-03 1.0e-01 NA 4.9e-03
15 TCGA Rectum Adenocarcinoma 0.5500 0.1390 8.5e-03 -0.008 -0.003 0.003 NA -0.006 5.3e-01 3.7e-01 2.7e-01 NA 4.6e-01
16 TCGA Stomach Adenocarcinoma 0.2140 0.0870 1.2e-03 0.056 0.050 0.033 NA 0.057 6.4e-05 1.7e-04 1.8e-03 NA 6.0e-05
17 TCGA Thyroid Carcinoma 0.0630 0.0320 2.0e-04 0.040 0.048 0.055 NA 0.059 9.1e-05 1.8e-05 4.2e-06 NA 2.1e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.3 0.4 2.0 0.4 -0.5 0.2 0.9 0.4 0.1 0.7 -0.3 0.8 -0.6 0.2 0.2 0.1 0.8 -1.4 0.2 0.9
Bipolar Disorder or Schizophrenia 0.1 0.1 1.5 0.1 -0.0 -0.0 0.2 0.1 -0.0 0.1 -0.3 0.7 -0.4 -0.4 -0.1 -0.0 -0.0 -1.2 -0.0 0.3
Depressed Affect (Nagel 2018) 0.4 0.8 2.9 0.8 0.4 0.4 0.7 0.8 1.2 0.7 -0.5 -1.2 1.3 0.7 0.2 0.9 0.7 1.7 0.7 0.7
Depression (Nagel 2018) 0.4 0.6 3.8 0.2 0.1 0.3 -0.6 0.2 1.6 -0.0 -2.0 0.1 0.0 -0.7 0.5 -1.2 -0.2 -0.0 0.3 -0.5
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.8 0.2 -1.4 -0.7 0.7 0.1 0.9 0.4 0.0 1.3 -0.5 1.3 1.0 -0.3 1.1 0.5 -0.0 0.8
Neuroticism (Nagel 2018) 0.1 0.3 1.3 0.2 -0.5 -0.4 -0.5 0.2 0.9 0.1 -1.1 -0.2 -0.3 -0.4 -0.7 -1.1 -0.2 0.4 0.2 -0.4
Schizophrenia (2018) 0.1 0.1 0.5 -0.2 0.4 -0.2 -0.5 -0.3 -0.1 -0.4 -0.1 0.3 -0.1 -0.6 -0.3 -0.1 -0.7 -0.4 -0.3 -0.4
Schizophrenia vs Biploar Disorder 1.1 1.4 3.2 1.6 -1.0 -0.7 1.2 1.7 1.2 1.5 1.1 0.7 0.5 1.1 -0.8 0.1 1.4 1.2 1.8 1.2
Worry (Nagel 2018) 1.2 2.6 10.0 -1.1 0.6 0.1 -2.2 -1.1 0.6 -1.4 -2.3 0.5 -1.7 -2.0 -0.2 -3.2 -1.8 -1.7 -1.3 -2.1
Alzheimer’s Disease (in mother) 0.4 0.5 2.0 -0.0 0.5 1.4 0.8 -0.0 0.5 0.1 -0.5 1.1 -0.2 1.0 1.3 0.5 0.7 -0.4 -0.1 0.6
Alzheimer’s Disease (in father) 1.1 1.1 4.8 0.8 -1.6 -2.2 0.8 0.8 -0.4 1.0 1.2 1.0 0.2 1.1 -0.7 0.2 0.8 1.8 0.6 0.9
Alzheimer’s Disease (including proxy) 0.3 0.5 2.2 -0.3 -1.2 -0.5 0.0 -0.2 -1.0 -0.3 1.5 1.0 -0.8 0.7 -0.1 -0.8 0.0 0.3 -0.4 -0.1
Crohns Disease (2017) 1.0 2.1 5.0 -1.9 -0.1 0.2 -1.6 -2.0 -1.3 -1.7 -1.3 -1.2 -0.2 -1.4 1.5 -0.8 -1.8 -1.4 -2.2 -1.6
Irritable Bowel Disease (IBD) 0.2 0.6 2.8 -0.8 0.8 0.6 -0.5 -0.6 0.3 -0.5 -0.9 -1.7 0.1 -0.4 1.5 -0.2 -0.6 -0.4 -0.7 -0.3
Ulcerative Colitis (UC) 0.5 0.9 3.1 0.8 1.6 0.8 0.7 1.1 1.8 1.1 -0.2 -1.3 0.7 0.3 0.7 0.4 0.8 0.4 1.1 0.9
Major Depression (MDD) 2.4 2.9 6.3 2.4 1.9 0.3 1.5 2.5 2.2 2.4 0.8 -0.2 2.4 -0.2 0.3 1.7 1.4 1.2 2.4 1.6
Reaction Time 0.8 1.5 3.9 1.4 -0.3 0.9 1.5 1.4 1.6 1.3 -1.3 0.2 -0.8 1.7 0.4 -0.3 2.0 -0.2 1.5 1.6
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.7 1.2 -0.9 -0.9 1.4 1.1 1.0 1.2 0.1 1.3 0.0 1.6 0.0 0.5 1.6 1.4 0.9 1.4
Breast Cancer 0.5 1.2 3.5 1.6 0.5 0.5 1.0 1.5 0.2 1.6 1.2 1.3 0.0 0.4 0.5 0.4 1.4 0.6 1.9 1.3
Ovarian Cancer 0.3 0.4 1.9 -0.6 0.1 0.2 -0.5 -0.6 -0.8 -0.6 -1.2 1.4 0.1 -0.4 0.3 -0.3 -0.6 -0.3 -0.4 -0.5
Prostate Cancer 0.3 0.5 1.6 0.3 0.3 -0.8 -0.4 0.3 -0.8 0.2 1.1 0.6 0.1 -1.3 -1.1 -0.6 -0.6 -0.1 0.6 -0.6
Age at First Birth 0.3 0.5 1.5 -0.5 -0.3 -0.5 -0.8 -0.5 0.3 -0.4 -1.2 -0.1 0.8 -1.1 0.9 -0.0 -0.7 0.1 -0.8 -0.7
Bipolar Disorder (2011) 0.6 0.5 1.8 -0.9 -0.9 -0.9 -0.5 -0.8 -0.5 -0.6 -1.4 -1.0 0.2 -0.6 0.2 0.5 -0.6 -0.5 -1.0 -0.5
Body Mass Index (BMI) (2010) 0.6 0.8 3.5 -0.6 1.2 1.6 0.1 -1.0 0.2 -0.6 -1.9 -0.3 0.0 0.7 1.4 0.9 0.2 -0.6 -0.9 0.3
Coronary Artery Disease (CAD) 0.4 0.5 1.7 -0.5 -0.2 -0.5 -0.6 -0.6 -0.7 -0.7 0.4 -0.9 -1.0 0.4 -1.1 -0.7 -0.5 -1.3 -0.6 -0.3
Crohns Disease (2012) 0.8 1.3 3.3 -1.6 -0.3 -0.2 -1.2 -1.5 -1.3 -1.3 -0.8 -0.6 -0.7 -1.0 1.1 -1.0 -1.4 -0.9 -1.8 -1.2
Mean Putamen Volume 1.4 1.6 3.2 1.3 -0.9 -1.4 1.7 1.3 0.5 1.4 -0.1 1.8 1.1 0.6 -0.7 1.7 1.2 1.5 1.5 1.2
Fasting Glucose 0.5 0.6 2.3 -0.1 1.4 1.1 -1.0 -0.4 -0.4 -0.3 0.1 1.1 -0.1 -1.1 0.5 -0.6 -0.7 -1.5 -0.7 -0.4
HbA1C 1.1 1.2 5.7 0.5 -1.2 0.2 1.5 0.9 -0.2 0.9 -0.5 1.0 0.2 2.4 0.8 0.5 1.9 1.0 1.2 1.2
HDL Cholesterol 1.0 1.7 6.6 -0.0 -1.7 -2.6 -0.9 0.0 -1.6 -0.2 1.2 -0.6 -2.0 -1.2 -2.0 -1.5 -0.7 -0.7 -0.0 -0.9
LDL Cholesterol 1.5 2.4 5.7 2.1 0.0 0.2 1.8 1.8 0.9 2.0 -0.2 1.7 -0.1 2.0 -1.3 0.5 2.4 0.7 2.2 2.2
Lupus 0.3 0.5 3.3 -0.1 -1.1 -0.5 0.2 -0.0 -0.8 -0.0 1.8 1.1 -0.5 0.4 -0.3 0.7 0.0 -0.6 0.2 0.2
Neuroticism (2016) 0.3 0.4 1.7 -0.4 0.7 -0.2 -1.0 -0.4 -0.3 -0.5 -1.3 -0.9 -0.0 -0.6 -0.7 -0.4 -0.7 -0.6 -0.5 -0.7
Primary Biliary Cirrhosis 1.8 2.6 6.0 1.8 -0.5 -0.4 2.1 1.8 1.8 1.9 0.3 0.7 0.8 2.4 -1.0 1.7 2.1 1.8 1.7 2.2
Rheumatoid Arthritis 1.3 1.8 3.9 -1.1 1.0 -0.1 -1.8 -1.1 -1.5 -1.3 1.1 1.0 -0.6 -1.8 -0.1 -2.0 -1.5 -1.6 -1.2 -1.8
Schizophrenia (2014) 0.1 0.3 1.2 0.1 -1.0 -1.1 0.3 0.2 0.4 0.1 -0.8 0.3 0.1 0.5 -1.0 0.2 0.1 0.6 0.3 0.2
Triglycerides 0.9 1.4 4.2 0.7 2.0 1.8 0.9 0.7 1.7 0.8 -0.5 1.0 2.0 0.7 1.2 0.9 0.8 0.7 0.9 1.0
Type 2 Diabetes (T2D) (2012) 3.4 3.9 10.9 -2.2 1.9 2.0 -2.0 -2.3 -1.1 -2.3 -0.4 -3.3 -0.9 -1.5 1.9 -1.2 -1.9 -2.6 -2.5 -1.7
Ulcerative Colitis 1.2 1.7 5.5 1.9 0.5 -0.4 1.4 1.8 2.4 1.9 -0.4 -0.6 0.9 0.6 -0.6 1.1 1.5 0.5 1.7 1.7
Blood Eosinophil Count 0.1 0.8 2.1 -1.1 1.4 1.1 -0.8 -1.1 -0.1 -0.9 0.7 -0.1 -0.5 -0.7 1.3 -0.7 -0.7 -1.4 -0.8 -0.8
Blood Platelet Count 0.3 3.3 7.3 2.0 1.4 1.1 2.4 2.0 1.9 2.3 -0.2 2.1 -0.4 1.7 2.1 -0.3 2.7 1.4 1.9 2.2
Blood Red Count 0.5 4.6 10.5 2.1 1.5 -0.8 3.0 2.1 1.2 2.2 0.3 -2.0 0.5 3.0 -1.8 3.2 2.7 1.9 2.3 2.9
Blood White Count 0.3 2.4 14.7 0.4 3.8 1.6 -0.1 0.4 2.2 0.6 0.6 -0.3 3.1 -1.6 1.6 1.8 -0.3 -0.1 0.5 0.0
Heel T-Score 0.2 1.8 4.9 1.5 1.3 -0.1 1.9 1.5 -0.1 1.7 -0.1 2.2 -0.1 1.3 0.7 1.0 1.5 1.3 1.8 1.6
BMI 0.1 0.6 3.2 -0.1 1.1 0.7 1.3 -0.1 -0.7 0.1 -0.9 0.7 -0.8 0.9 -0.5 1.8 0.1 0.5 0.4 0.5
Height 0.1 1.1 4.0 0.6 -1.9 -0.7 1.0 0.7 0.8 0.7 -0.7 -0.8 1.2 1.2 -0.2 2.0 0.9 0.6 0.4 1.4
Waist Hip Ratio (WHR) 0.1 0.3 1.9 0.4 0.2 0.3 -0.2 0.4 0.5 0.2 -0.8 1.2 -0.5 0.1 -1.4 -0.5 0.1 -0.2 0.3 -0.0
Systolic Blood Pressure 0.5 2.3 10.0 -0.1 -3.2 -3.1 0.4 -0.1 -1.5 -0.1 0.8 -0.8 -2.5 1.1 -2.7 -0.5 0.2 -0.2 0.3 0.0
Smoking Status 0.7 1.7 4.6 -1.4 1.4 1.5 -1.5 -1.5 -1.3 -1.5 2.1 -1.1 0.2 -0.9 0.9 -0.4 -1.5 -1.0 -1.2 -1.3
Allergy or Eczema 0.3 0.7 4.4 0.3 0.0 0.4 0.7 0.3 1.2 0.6 -0.5 0.9 0.9 0.6 2.1 0.2 0.8 0.8 0.2 0.7
Cardiovascular Disease 0.3 1.1 3.9 1.0 -0.2 -1.4 1.0 1.0 -0.6 0.9 0.2 0.2 -0.1 1.2 -2.0 1.5 0.9 0.8 1.3 1.0
Hypothyroidism (self reported) 0.7 1.7 5.2 -1.4 -1.1 -1.3 -1.8 -1.3 -2.3 -1.4 -0.7 0.2 -0.1 -1.4 -1.1 -0.3 -1.5 -0.9 -1.3 -1.6
Respiratory disease 0.5 1.2 3.1 1.1 0.9 1.8 1.4 1.1 0.5 1.2 0.1 0.7 0.4 1.0 1.0 1.4 1.2 -0.1 1.1 1.5
Type 2 Diabetes (T2D) (2018) 1.5 2.7 5.6 2.1 0.9 -0.3 1.8 2.1 1.0 1.8 -0.7 1.1 1.7 1.0 -2.2 2.3 1.4 1.9 2.4 1.6
Lung FEV1/FVC ratio 0.2 1.2 3.9 -1.4 -0.8 -0.6 -1.2 -1.4 -1.0 -1.2 -0.3 -0.1 0.2 -1.6 0.4 0.3 -1.4 -1.3 -2.0 -1.1
Lung FVC 0.3 1.8 3.6 -1.7 0.1 -0.0 -1.9 -1.7 -1.4 -1.8 1.6 0.5 -0.3 -1.1 0.7 -1.5 -1.7 0.2 -1.5 -1.9
Neuroticism 0.2 0.5 3.2 -0.2 1.2 0.5 -0.5 -0.2 0.9 -0.4 -1.8 -0.4 -0.3 -0.3 -0.1 -0.8 -0.5 0.3 -0.1 -0.6
Chronotype (morning person) 0.7 1.6 5.4 1.4 0.7 -0.1 0.8 1.4 2.3 1.4 0.0 0.6 2.3 0.1 -0.7 1.9 0.8 1.5 1.3 1.0
Hair Pigment 0.0 1.2 6.2 -0.9 -1.2 -1.8 -0.6 -0.9 -1.5 -0.8 0.2 1.0 -2.5 0.3 -1.4 -0.9 -0.6 -0.1 -0.7 -0.7
Tanning 0.1 0.6 4.0 -0.0 1.1 0.9 0.5 -0.0 0.5 -0.0 -1.2 -0.1 0.2 1.0 1.1 -0.3 0.2 2.0 0.5 0.2
Hand grip strength (left) 0.3 0.7 3.3 -0.7 -1.8 -0.9 -0.4 -0.7 -1.4 -0.7 -0.2 0.7 -1.5 0.0 -0.8 -0.6 -0.3 -0.8 -0.6 -0.5
Number of treatments/medications taken 1.2 2.2 6.3 1.1 -0.5 -0.2 2.1 1.1 1.0 1.2 -1.4 -1.5 0.5 2.5 -0.5 2.5 1.6 1.8 1.2 1.9
Average weekly spirits intake 0.4 0.6 3.0 0.3 0.9 -0.4 0.5 0.3 -0.2 0.4 0.7 -1.5 1.0 -0.2 -0.5 1.7 -0.0 0.6 0.3 0.4
Sensitivity / hurt feelings 0.3 0.5 3.1 0.3 -0.3 -0.8 -0.1 0.3 0.9 0.2 -1.8 0.2 0.9 -0.4 -0.9 0.8 -0.2 0.7 0.5 -0.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.1 0.2 -0.1 0.2 -0.6 0.2 0.5 0.0 -1.0 0.6 0.5 -1.0 0.6 -0.7 -0.3 0.1 0.3 -0.6
Hearing difficulty/problems: Yes 0.2 0.4 3.3 0.3 1.8 1.0 0.3 0.3 -0.2 0.3 -0.2 0.5 0.1 -0.2 0.9 0.2 0.3 -0.1 0.2 0.2
Relative age of first facial hair 0.7 1.5 3.3 -1.5 0.6 -0.6 -1.4 -1.5 -0.9 -1.1 0.1 -1.4 0.4 -1.8 1.8 -0.8 -1.5 -0.4 -1.8 -1.3
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 3.4 0.8 1.7 0.5 0.4 0.8 1.2 0.8 -0.0 -0.1 1.8 -0.1 -0.2 1.5 0.4 0.6 0.9 0.5
Ever used hormone-replacement therapy (HRT) 1.2 1.5 6.3 0.7 0.5 0.5 1.2 0.7 1.4 0.7 0.0 -1.0 2.1 1.5 -0.5 1.9 0.8 2.5 0.5 1.0
Ever had hysterectomy (womb removed) 0.5 0.6 2.9 -0.1 -1.7 -0.6 0.4 -0.1 0.7 0.0 -1.4 -0.1 -0.1 1.3 -0.8 0.6 0.5 0.7 -0.1 0.4
Systolic blood pressure, automated reading 0.6 1.8 6.0 1.0 -2.4 -2.0 1.5 1.0 0.4 1.1 0.0 -1.4 -0.4 1.6 -1.4 1.5 1.1 1.5 1.1 1.3
Eye problems/disorders: Diabetes related eye disease 7.5 8.2 16.0 3.5 -0.8 0.0 4.0 3.5 2.2 3.6 0.6 3.0 1.5 3.2 -0.9 3.3 3.8 1.8 3.7 3.9
Angina 0.7 0.9 2.7 1.3 0.8 -0.1 0.5 1.3 -0.6 1.1 1.5 -1.3 0.4 -0.0 -1.6 0.5 0.5 0.5 1.1 0.6
Medication for hormone replacement therapy 0.1 0.2 0.7 0.1 0.7 0.5 0.5 0.1 -0.0 0.2 0.2 0.2 0.0 0.5 -0.1 0.9 0.3 -0.3 0.2 0.5
Vitamin and mineral supplements 0.7 0.9 7.1 1.1 -0.5 -1.2 0.5 1.1 -0.3 0.8 -0.3 0.7 0.0 0.6 -2.7 0.2 0.5 0.7 1.1 0.6
Supplements: Zinc 1.4 1.5 5.6 -1.1 0.7 1.9 -1.1 -1.1 -0.2 -1.0 -0.4 -1.0 -1.1 -1.1 1.3 -1.3 -1.2 -2.4 -1.2 -0.9
Medication: Co-codamol 0.5 0.6 3.7 -0.0 1.2 0.3 0.1 -0.0 0.6 -0.1 0.4 0.2 1.7 -0.4 0.3 1.2 -0.5 1.9 0.3 -0.3
Medication: Metformin 1.0 1.5 7.5 0.6 1.7 0.5 1.4 0.6 0.8 0.6 -0.4 -0.9 1.4 1.2 -1.2 2.7 0.4 1.5 1.1 1.1
Diabetes (father) 2.0 2.5 7.3 1.7 0.1 -0.6 1.4 1.7 1.8 1.8 -0.4 -1.1 2.7 0.2 -0.1 2.7 1.0 2.4 1.6 1.4
Diabetes (mother) 0.5 0.6 4.8 -0.0 2.2 1.5 -0.1 -0.0 -0.2 -0.2 0.1 0.7 -0.7 -0.4 -0.3 -0.7 -0.4 -0.7 0.4 -0.4
Severe depression (siblings) 0.4 0.5 1.5 -0.8 -0.3 -0.8 -0.5 -0.8 -0.9 -0.7 0.4 -0.6 0.2 -0.8 0.9 0.6 -0.4 -0.5 -1.2 -0.4
Pack years adult smoking proportion 0.4 0.6 2.4 -0.6 -0.3 -1.2 -0.9 -0.6 -0.2 -0.6 0.2 -1.6 -0.8 -0.7 -0.9 -0.4 -0.7 -0.6 -0.4 -0.8
Impedance of leg (right) 0.2 0.8 3.3 0.5 -0.7 -1.1 -1.4 0.5 0.7 0.2 0.7 -1.2 0.5 -1.4 -0.9 -1.8 -0.4 0.0 0.1 -0.7
Leg fat-free mass (left) 0.1 0.6 4.2 -0.0 0.1 0.7 1.5 -0.0 -0.4 0.3 0.3 -0.3 0.0 0.9 0.6 2.1 0.5 -0.0 0.1 1.0
Trunk fat percentage 0.4 1.6 6.4 1.0 2.5 1.5 1.4 1.0 1.2 1.1 -1.1 -0.0 0.9 0.2 0.3 2.3 0.7 0.6 0.9 1.2
Hand grip strength (right) 0.2 0.6 2.3 -0.5 -1.4 -1.5 -0.3 -0.5 -1.1 -0.6 -1.0 0.9 -0.6 0.0 -0.8 0.4 -0.4 0.3 -0.4 -0.4
Townsend deprivation index at recruitment 2.2 3.0 5.5 -2.0 1.6 0.7 -2.0 -2.0 -2.3 -2.2 1.0 -0.7 -1.9 -1.2 -0.0 -2.3 -2.3 -1.1 -1.6 -2.3
Current tobacco smoking 0.3 0.5 2.3 -0.8 -0.1 -0.6 -0.1 -0.8 -0.3 -0.5 1.5 -1.1 0.5 0.3 0.2 0.6 -0.3 0.7 -1.1 -0.1
Average weekly fortified wine intake 0.4 0.5 2.8 0.3 0.4 0.8 1.0 0.3 0.9 0.4 -1.1 -1.7 -0.3 0.6 0.4 0.4 0.6 -0.3 0.0 0.7
Maternal smoking around birth 1.5 2.1 5.3 1.3 1.6 2.2 1.4 1.4 2.3 1.4 -0.9 -0.7 1.3 0.9 1.5 1.6 1.6 -0.2 1.4 1.6
Fed-up feelings 0.1 0.2 0.6 -0.3 -0.8 -0.1 -0.8 -0.3 0.3 -0.4 0.1 0.8 0.3 -0.5 -0.3 0.1 -0.4 -0.2 -0.3 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 2.8 -0.7 1.1 0.6 -1.4 -0.7 0.4 -0.9 -1.3 0.5 -0.7 -1.4 -0.1 -1.7 -1.1 -1.3 -0.3 -1.4
Relative age voice broke 0.3 0.5 2.7 0.1 -0.2 -0.6 0.9 0.0 0.8 0.3 -1.6 0.2 0.5 0.9 0.4 0.9 0.6 0.8 -0.0 0.7
Taking other prescription medications 1.5 2.3 4.9 1.4 1.5 0.9 2.1 1.4 1.7 1.5 -1.3 -0.5 1.2 1.7 -0.1 2.2 1.5 1.8 1.5 1.8
Age when periods started (menarche) 0.1 0.3 1.8 0.0 0.1 0.0 -0.5 0.0 -0.6 -0.1 -0.5 0.7 -1.4 -0.5 0.0 -1.3 -0.3 -0.2 0.3 -0.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.3 -0.6 -1.1 -1.1 -0.7 -0.6 0.0 -0.7 -1.5 -0.6 -0.9 -0.1 -1.3 -0.7 -0.4 -0.1 -0.7 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.7 0.3 -0.1 -0.8 -0.1 0.3 -0.1 0.4 -0.2 0.7 -0.0 -0.6 0.9 -0.2 0.2 -0.1 0.2 0.0
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 4.1 -0.4 0.9 0.2 -0.5 -0.4 -1.2 -0.4 0.0 2.0 -1.2 -1.0 0.6 -0.9 -0.6 -0.6 -0.2 -0.6
Qualifications: CSEs or equivalent 0.3 0.4 1.2 0.6 0.7 0.6 0.2 0.6 -0.6 0.6 1.1 1.0 -0.2 -0.8 0.2 -0.1 0.3 -1.0 0.6 0.2
Serious illness, injury or assault to yourself 3.2 3.9 7.9 2.7 0.8 1.2 2.8 2.6 1.3 2.7 0.6 -1.4 0.7 2.0 -0.3 1.7 2.7 1.0 2.6 2.8
High blood pressure 0.5 1.3 4.4 1.3 -0.3 -1.2 1.2 1.4 0.2 1.3 0.2 -0.1 0.3 1.1 -2.1 1.2 1.0 1.2 1.6 1.1
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.3 0.1 -0.7 -0.3 0.6 0.1 0.5 0.3 -0.7 1.1 -0.5 0.7 0.8 -0.1 0.6 0.3 0.1 0.5
Multivitamins +/- minerals 1.1 1.4 6.7 -1.4 -0.3 0.8 -1.0 -1.4 0.2 -1.2 1.2 -0.6 0.5 -1.3 2.6 -0.2 -0.9 -1.0 -1.7 -1.0
Stomach or abdominal pain in last month 0.4 0.4 2.1 0.2 0.9 0.6 0.4 0.3 0.6 0.3 0.5 -0.7 1.1 0.2 0.7 1.5 0.2 0.8 0.3 0.4
Supplements: Glucosamine 0.9 1.1 4.4 0.6 -1.1 0.4 1.1 0.6 1.2 0.8 0.1 0.1 1.9 0.6 1.6 2.1 1.0 0.9 0.5 1.1
Diverticular disease/diverticulitis (self-reported) 2.7 3.2 9.0 2.0 0.4 0.1 1.7 2.0 2.7 2.2 -0.2 0.0 3.0 0.4 0.9 2.9 1.5 1.7 2.0 2.0
Medication: Atenolol 1.3 1.6 7.2 -0.3 -0.6 -1.4 -0.2 -0.3 -1.8 -0.5 0.5 -2.0 -2.6 1.3 -2.7 -0.9 -0.2 -0.5 -0.3 -0.1
Medication: Levothyroxine sodium 0.4 0.6 3.0 -0.4 -1.2 -1.7 -0.9 -0.4 -1.2 -0.5 -0.1 0.0 0.4 -0.6 -1.3 0.7 -0.8 0.2 -0.5 -0.6
Sitting height 0.1 0.7 6.3 -0.5 0.3 0.7 -0.2 -0.5 -0.3 -0.5 1.2 -2.5 1.1 -0.3 0.4 1.0 -0.5 0.1 -0.5 -0.1
Chronic bronchitis/emphysema (father) 1.1 1.3 3.1 -0.7 1.2 1.4 -1.4 -0.7 -0.8 -1.0 -1.0 -1.5 -0.3 -1.8 -0.0 -1.8 -1.2 -1.0 -0.7 -1.4
High blood pressure (mother) 0.4 0.5 1.9 0.8 -0.7 -0.8 -0.4 0.8 -0.7 0.7 -1.3 -0.0 -0.0 -0.7 -1.4 -0.3 -0.0 -0.7 0.8 0.0
Body mass index (BMI) 0.2 1.0 4.8 0.4 1.9 1.7 1.7 0.4 0.2 0.5 -0.5 0.1 0.1 0.8 0.3 2.2 0.6 0.1 0.6 1.0
Impedance of leg (left) 0.3 1.3 4.6 0.3 -0.9 -1.7 -1.9 0.3 0.0 -0.0 0.9 -1.0 0.3 -2.0 -1.6 -2.1 -0.8 -0.2 -0.1 -1.1
Leg predicted mass (left) 0.1 0.6 4.2 -0.0 0.2 0.7 1.5 -0.0 -0.4 0.2 0.3 -0.3 0.0 1.0 0.7 2.0 0.5 0.0 0.0 1.0
Trunk fat mass 0.3 1.2 5.4 0.7 2.2 1.5 1.5 0.7 0.8 0.8 -0.9 -0.3 0.6 0.4 0.3 2.3 0.6 0.4 0.7 1.1
Waist circumference 0.5 1.9 6.0 1.2 2.0 1.6 2.1 1.2 1.2 1.3 -0.7 0.2 0.5 1.3 -0.2 2.5 1.3 0.5 1.3 1.7
Number of incorrect matches in round 0.5 0.8 3.4 -0.3 -0.9 -1.6 -0.5 -0.3 -1.0 -0.5 -1.3 0.6 -0.6 -0.4 -1.8 -1.1 -0.7 -0.3 -0.3 -0.8
Past tobacco smoking 1.4 2.6 7.2 1.7 -2.0 -2.7 1.4 1.7 1.7 1.8 -0.3 0.8 1.0 0.9 -2.2 1.9 1.4 1.5 1.2 1.6
Alcohol usually taken with meals 0.6 1.0 3.4 0.5 -0.3 -0.9 1.5 0.5 -1.0 0.6 -0.7 1.2 -1.5 1.9 -1.1 1.0 0.7 0.5 0.7 1.1
Nervous feelings 0.5 0.9 4.6 -0.3 -0.1 -0.5 -1.3 -0.3 0.5 -0.6 -1.6 0.4 -1.3 -1.0 -0.7 -2.1 -1.0 -0.6 -0.3 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 2.4 0.4 0.6 0.6 -0.3 0.4 0.1 0.1 -0.1 1.5 -0.5 -0.2 -0.5 -1.5 0.0 -0.3 0.6 -0.3
Hearing difficulty/problems with background noise 0.5 0.8 4.4 0.0 1.6 0.8 -0.7 0.0 -0.5 -0.1 -1.5 2.1 0.1 -1.2 0.3 -0.8 -0.7 -0.4 -0.1 -0.7
Hair/balding pattern: Pattern 2 0.2 0.3 1.0 -0.6 -1.0 -0.6 -0.4 -0.6 -0.2 -0.5 0.4 -0.9 -0.3 0.1 -0.4 -0.0 -0.2 -0.6 -0.6 -0.2
Had menopause 2.4 3.0 9.7 1.3 0.3 -0.0 2.0 1.3 1.5 1.4 -1.2 -1.1 1.8 2.6 -0.6 2.8 1.9 3.1 1.3 2.0
Had other major operations 0.6 0.8 4.3 0.5 1.3 2.1 0.8 0.5 0.9 0.5 -0.4 -0.7 -0.7 0.9 0.8 0.4 0.8 -0.1 0.9 0.8
Forced vital capacity (FVC) 0.4 1.7 4.4 -1.7 -0.6 -0.3 -2.1 -1.7 -1.3 -1.9 0.7 -0.3 -0.2 -1.2 0.6 -1.6 -1.5 -0.3 -1.4 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.8 0.9 0.7 0.3 0.2 0.9 0.8 0.9 -0.7 0.4 0.4 -0.5 0.7 -0.1 0.6 -0.1 0.7 0.5
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 4.5 0.7 1.6 1.8 0.5 0.7 1.5 0.8 -0.7 -1.7 0.5 -0.2 2.1 -0.7 0.6 -0.1 0.8 0.5
Qualifications: None of the above 0.4 0.9 7.1 0.3 2.7 2.2 -0.0 0.3 0.5 -0.0 -0.5 -0.1 0.8 -0.6 -0.1 0.5 -0.3 -0.1 0.6 -0.2
Financial difficulties in last 2 years 1.4 1.8 7.5 0.1 2.7 2.0 1.0 0.1 -0.1 0.2 2.7 -1.9 1.0 0.9 1.8 0.4 0.3 1.4 0.5 0.5
Mouth/teeth dental problems 0.2 0.3 0.8 0.7 0.0 0.4 0.4 0.7 0.8 0.8 0.0 -0.1 0.9 -0.4 0.4 0.2 0.5 -0.4 0.4 0.5
Heart attack 1.0 1.3 8.5 1.1 -0.4 -1.7 0.5 1.1 0.1 1.1 0.4 -1.8 -0.6 0.8 -2.9 0.4 0.8 0.4 0.6 1.0
Allergy 0.2 0.4 1.3 -0.3 -0.1 -0.9 -0.9 -0.3 -0.7 -0.5 0.7 -0.4 0.1 -0.7 -1.1 -0.7 -0.6 -0.3 -0.3 -0.8
Pain all over the body in last month 1.0 1.1 3.6 -0.7 0.6 0.0 -1.1 -0.7 -0.4 -0.8 -1.7 1.0 -0.6 -1.7 -0.6 -1.1 -1.1 -1.9 -0.8 -1.2
Diabetes (self-reported) 2.6 4.0 8.5 2.7 0.4 -0.2 2.3 2.7 1.4 2.5 0.3 1.3 1.8 1.3 -2.0 2.6 2.1 1.9 2.9 2.3
Hayfever/allergic rhinitis (self-reported) 3.8 5.0 11.9 2.1 -0.3 0.5 3.4 2.1 3.4 2.4 -1.2 0.3 1.1 2.6 1.2 3.0 2.9 2.0 2.3 3.0
Medication: Ramipril 2.4 3.0 6.3 2.5 -0.9 -0.8 1.8 2.5 0.7 2.3 0.3 2.3 1.1 1.2 -1.6 1.3 1.9 1.7 2.5 1.9
Medication: Simvastatin 2.1 3.0 5.4 2.1 1.3 0.9 2.2 2.2 1.5 2.1 0.1 -0.2 1.0 2.2 -1.2 2.2 2.1 1.4 2.2 2.3
Fluid intelligence score 0.4 0.8 3.4 0.7 -0.6 -0.6 0.9 0.7 1.8 0.8 -1.4 0.1 -0.2 1.3 0.2 0.2 1.1 0.9 0.4 1.1
Illnesses of siblings 0.6 0.8 4.1 0.6 0.1 0.2 0.5 0.6 0.8 0.6 1.8 0.6 2.0 0.3 -0.1 1.7 0.5 0.8 0.6 0.6
Neuroticism score 0.2 0.4 2.1 0.0 0.1 -0.2 -0.5 0.0 0.8 -0.2 -1.4 0.0 -0.7 -0.5 -1.1 -1.1 -0.4 -0.2 0.3 -0.6
Weight 0.2 1.1 6.7 0.6 1.1 1.1 1.9 0.6 0.0 0.7 0.0 -0.4 0.4 1.1 0.2 2.6 0.8 0.5 0.7 1.3
Impedance of arm (right) 0.2 0.8 3.8 1.0 -0.2 -0.4 -0.2 1.0 1.9 0.9 -1.5 -0.4 1.3 -0.0 0.1 -0.1 0.7 0.7 0.8 0.6
Arm fat percentage (right) 0.5 2.1 7.1 1.0 2.7 1.9 2.0 1.0 1.1 1.2 -1.3 0.3 0.8 1.1 0.4 2.7 1.1 0.6 1.2 1.6
Trunk fat-free mass 0.1 0.6 3.0 -0.0 -0.8 -0.5 1.2 -0.0 -0.7 0.2 0.8 -0.9 -0.2 1.1 -0.5 1.7 0.4 0.5 0.2 0.8
Hip circumference 0.7 2.9 11.2 1.2 1.6 1.6 2.9 1.2 1.2 1.4 0.2 -0.4 1.0 2.1 0.8 3.3 1.7 1.2 1.3 2.3
Time employed in main current job 0.4 0.5 2.4 0.1 -1.5 -0.8 -0.6 0.1 -0.6 0.0 -0.2 0.6 0.0 -1.0 -1.2 -0.6 -0.3 -0.6 0.1 -0.5
Alcohol intake versus 10 years previously 0.1 0.1 0.7 -0.1 -0.2 -0.8 0.1 -0.1 0.3 -0.1 -0.6 0.4 0.3 -0.1 -0.6 0.5 0.0 -0.0 -0.2 -0.0
Father’s age at death 0.5 0.7 3.4 -0.4 -0.5 -0.2 0.2 -0.4 0.8 -0.3 -1.8 0.0 1.4 0.3 1.0 1.3 -0.4 1.5 -0.5 0.0
Worrier / anxious feelings 0.3 0.5 1.7 0.1 -0.7 -0.3 -0.7 0.1 1.1 -0.1 -0.9 1.0 0.2 -0.8 -1.3 -1.3 -0.2 -0.7 0.1 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 2.7 0.2 0.1 -0.3 0.2 0.2 0.4 0.2 0.2 -1.1 0.2 0.8 -0.4 0.1 0.3 1.6 0.7 0.2
Falls in the last year 0.6 0.8 3.4 0.6 1.0 1.5 0.8 0.6 -0.3 0.6 1.9 0.7 0.3 1.1 0.8 0.5 0.7 0.5 0.6 0.8
Hair/balding pattern: Pattern 3 0.3 0.4 2.2 0.8 1.5 0.1 0.1 0.8 0.9 0.5 -0.7 0.6 0.2 -0.2 -0.9 -0.1 -0.1 0.2 0.8 0.2
Number of live births 0.6 0.9 2.6 0.7 0.1 -0.1 1.2 0.7 0.0 0.8 1.6 0.2 0.6 1.4 -0.2 1.2 0.9 1.5 0.9 1.0
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 5.0 -1.9 -1.1 -0.8 -2.2 -1.9 -1.3 -2.0 0.3 0.1 -0.1 -1.6 0.6 -1.6 -1.8 -0.3 -1.6 -2.1
Pulse rate 1.3 2.2 8.1 0.3 -1.8 -0.6 1.3 0.3 -1.6 0.6 1.9 2.8 -2.0 2.9 -0.0 0.0 1.6 0.7 0.5 1.4
Happiness 1.3 1.5 5.2 -0.9 1.3 1.3 -1.8 -0.9 -0.7 -1.1 0.9 -0.3 0.2 -1.9 0.4 -2.3 -1.3 -1.2 -0.6 -1.7
Noisy workplace 3.2 3.9 8.5 2.9 -0.6 -0.3 2.4 2.9 2.4 2.9 1.3 0.8 0.6 1.4 -0.7 1.1 2.8 1.2 2.5 2.6
Qualifications: A levels/AS levels or equivalent 0.9 2.1 7.6 -1.7 -2.8 -1.7 -0.8 -1.7 -2.7 -1.4 1.2 0.7 -1.4 0.7 0.6 -0.4 -0.6 -0.2 -1.9 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.0 0.0 0.7 0.9 0.2 0.0 0.2 0.1 0.4 -1.0 0.8 -0.3 0.9 0.3 -0.3 0.6 0.2 -0.0
Mouth/teeth dental problems: Dentures 0.4 0.6 2.2 -0.9 0.1 0.3 -0.2 -0.9 -0.4 -1.0 1.0 -1.5 -1.2 1.3 -0.2 -0.6 -0.4 0.5 -0.5 -0.4
Asthma 1.4 2.8 5.4 2.0 0.9 1.9 2.2 2.0 1.6 2.1 -0.2 0.3 1.3 1.5 0.5 2.0 2.0 0.9 2.0 2.3
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 1.7 -0.4 -0.9 0.2 0.1 -0.4 -0.2 -0.4 0.4 0.3 -1.3 0.5 -0.1 -0.5 0.1 -1.2 -0.4 -0.1
Medication: Cholesterol lowering 2.7 4.2 8.5 2.4 1.8 1.1 2.8 2.4 1.7 2.4 -0.7 -0.9 0.5 2.7 -1.2 2.5 2.5 1.0 2.5 2.9
Depression (self-reported) 0.6 0.7 2.6 -0.8 -0.1 -0.3 -1.1 -0.8 -0.6 -0.6 -0.2 -0.1 -0.1 -0.9 1.6 -1.4 -0.6 -0.5 -1.1 -0.9
Medication: Lansoprazole 0.8 0.9 2.0 -1.1 0.6 1.4 -1.1 -1.1 -0.1 -1.2 -1.4 0.2 0.7 -0.7 0.6 -0.6 -1.2 -0.1 -1.2 -1.1
Prospective memory result 0.4 0.5 2.5 0.5 0.6 0.3 0.8 0.5 -0.2 0.6 -0.4 -0.3 1.3 0.4 0.2 1.6 0.4 0.7 0.2 0.8
Lung cancer (father) 0.6 0.7 2.8 -0.3 0.5 0.2 -1.2 -0.3 -0.6 -0.7 1.0 0.3 -0.9 -0.5 -1.3 -1.7 -0.8 -0.7 -0.1 -1.0
Illnesses of mother 0.8 0.9 3.1 -1.2 1.0 1.2 0.1 -1.2 -0.3 -1.0 1.3 1.0 0.7 0.7 1.8 0.9 -0.3 1.0 -1.0 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.5 7.7 -2.3 -1.5 -1.1 -2.8 -2.3 -1.9 -2.4 1.0 0.7 -0.3 -2.2 0.2 -2.0 -2.3 -0.7 -2.2 -2.7
Pulse wave Arterial Stiffness index 0.2 0.2 1.3 0.1 -1.1 0.1 0.0 0.1 -0.5 0.1 0.7 -1.2 -0.5 0.3 0.3 -0.3 0.4 -0.2 0.1 0.2
Impedance of arm (left) 0.2 0.8 4.3 1.1 0.4 0.3 0.0 1.1 2.1 1.0 -1.2 -0.1 1.4 -0.1 0.7 0.1 0.9 0.4 0.7 0.7
Arm fat mass (right) 0.3 1.4 6.3 0.7 2.1 1.4 1.9 0.7 0.6 0.9 -0.8 -0.1 0.3 1.1 0.1 2.5 0.8 0.6 0.9 1.4
Trunk predicted mass 0.1 0.6 3.2 0.0 -0.7 -0.4 1.2 0.0 -0.6 0.2 0.8 -0.8 -0.1 1.1 -0.6 1.8 0.4 0.5 0.2 0.8
Standing height 0.1 0.6 2.7 0.4 -1.6 -1.2 0.5 0.4 -0.3 0.5 0.9 -1.2 0.5 0.6 -0.2 1.1 0.5 0.6 0.1 0.8
Length of working week for main job 2.1 2.4 4.9 -1.7 -0.9 -1.3 -1.7 -1.7 -2.2 -1.7 0.5 0.4 -2.0 -1.5 -0.5 -1.7 -1.5 -1.6 -1.5 -1.9
Exposure to tobacco smoke at home 1.1 1.2 6.6 0.8 1.8 2.6 1.3 0.8 0.1 0.8 1.9 0.2 0.0 0.9 1.0 -0.0 1.0 -0.2 1.0 0.8
Breastfed as a baby 2.2 2.8 7.0 -2.4 -0.1 -0.8 -1.7 -2.4 -2.6 -2.4 -0.5 1.6 -1.1 -0.4 -1.0 -0.6 -1.9 -1.0 -2.5 -1.8
Tense / ‘highly strung’ 0.5 0.8 3.5 -0.4 -0.3 -0.5 -0.6 -0.4 0.1 -0.5 -1.0 1.7 -1.9 -0.4 -0.1 -1.8 -0.6 0.0 0.0 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.8 0.6 1.3 0.4 0.2 0.6 0.7 0.6 0.1 -0.9 0.7 -0.4 0.5 0.3 0.5 -0.1 0.2 0.4
Hair/balding pattern: Pattern 4 0.9 2.1 6.0 2.0 0.1 0.3 1.7 2.0 1.2 1.8 -0.7 0.9 0.5 1.6 -1.3 0.9 1.6 1.6 2.5 1.5
Birth weight of first child 0.8 1.4 6.9 0.2 -2.6 -1.5 0.7 0.2 -0.5 0.3 1.6 2.6 -1.0 1.3 -0.8 -0.3 1.0 0.4 0.0 0.7
Peak expiratory flow (PEF) 0.6 1.4 4.0 -1.3 -0.8 -0.3 -1.4 -1.3 -2.0 -1.4 1.4 0.1 -1.0 -0.8 0.6 -1.6 -1.3 0.2 -0.9 -1.6
Pulse wave reflection index 0.4 0.4 2.0 0.7 0.2 -0.5 -0.1 0.7 0.9 0.5 -0.1 -1.4 0.6 -1.1 -1.3 0.1 -0.0 -0.1 0.5 -0.1
Ever highly irritable/argumentative for 2 days 1.7 2.0 4.9 1.7 0.3 1.1 2.2 1.7 1.3 1.7 0.6 -0.6 -0.2 2.2 -0.2 0.3 2.1 0.8 1.8 2.0
Loud music exposure frequency 0.1 0.1 0.6 0.4 -0.1 -0.8 -0.2 0.4 -0.1 0.2 0.4 -0.1 0.1 -0.4 -0.6 -0.6 0.1 -0.3 0.1 -0.1
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.9 -0.2 -1.1 -0.7 0.0 -0.2 0.5 0.1 -0.1 1.4 0.4 0.5 0.2 0.5 0.4 0.2 -0.2 0.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 1.2 -0.2 0.4 0.2 -0.5 -0.2 -0.4 -0.1 0.8 1.1 0.0 -0.4 0.6 -0.4 -0.2 -0.0 -0.1 -0.2
Blood clot in the leg (DVT) 0.6 0.8 2.8 -0.9 -0.4 -0.5 -1.1 -0.9 -1.7 -0.9 -1.3 -1.2 0.1 -0.5 -0.1 0.6 -1.0 0.2 -1.1 -0.7
Medication: Paracetamol 0.3 0.5 2.6 -0.1 -1.1 -1.1 -0.6 -0.1 -0.5 -0.2 -1.6 1.1 -0.6 -0.3 -0.9 0.0 -0.2 -0.6 -0.4 -0.2
Headache pain in last month 0.3 0.5 1.1 0.6 0.1 -1.0 0.4 0.6 -1.0 0.7 0.8 0.7 0.1 0.7 -1.1 0.7 0.6 0.8 0.8 0.6
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 3.9 -1.9 -1.9 -1.1 -1.9 -1.9 -1.0 -1.8 1.3 1.2 -0.5 -1.4 0.1 -1.5 -1.7 -0.6 -2.0 -1.9
Glaucoma (self-reported) 1.5 1.8 4.6 -2.1 -0.1 -0.5 -1.1 -2.1 -1.5 -2.0 -0.7 -1.8 -1.1 -0.3 0.8 -0.2 -1.6 0.0 -1.8 -1.4
Gout (self-reported) 0.4 0.5 2.6 0.4 -0.7 -1.4 -0.1 0.4 0.5 0.5 0.4 -0.3 1.6 -0.3 0.1 0.6 0.1 1.4 0.3 0.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.9 -0.9 -0.6 -0.9 -1.1 -0.9 -1.7 -0.9 -0.8 -0.1 0.1 -1.0 -0.7 0.2 -1.0 -0.7 -0.9 -0.9
Medication: Amlodipine 0.9 1.2 2.1 1.2 0.0 -0.4 1.4 1.2 1.2 1.2 -0.5 0.7 0.8 1.5 -0.9 1.3 1.1 1.2 1.4 1.3
Medication: Ventolin 100micrograms inhaler 2.0 2.5 5.3 1.9 0.0 0.6 2.0 1.9 0.9 1.9 -0.5 1.9 0.7 2.3 -0.6 1.8 2.2 0.9 1.6 2.3
Birth weight 1.9 4.0 8.2 2.8 -2.5 -1.2 2.2 2.8 1.9 2.6 0.5 2.4 0.3 1.3 -1.3 0.7 2.5 1.0 2.9 2.2
Chronic bronchitis/emphysema (mother) 1.8 2.1 10.6 1.5 3.3 2.7 0.8 1.5 1.6 1.4 0.9 0.9 0.5 0.3 -0.2 0.4 1.2 -1.2 1.6 1.2
High blood pressure (siblings) 0.9 1.4 8.4 -0.9 -0.4 -0.1 -0.3 -0.9 -1.0 -0.8 -2.1 -0.4 -2.9 0.0 0.1 -1.9 -0.5 -1.3 -0.9 -0.7
Forced vital capacity (FVC), Best measure 1.0 3.8 8.5 -2.3 -1.3 -1.0 -2.9 -2.3 -2.3 -2.5 1.5 0.5 -0.8 -2.1 -0.1 -2.5 -2.3 -0.9 -2.2 -2.7
Body fat percentage 0.4 1.4 7.2 0.8 2.7 1.7 1.3 0.8 1.0 0.8 -1.1 -0.2 0.8 0.2 0.4 2.1 0.6 0.3 0.7 1.0
Leg fat percentage (right) 0.3 1.1 5.1 0.6 2.2 2.0 1.4 0.6 0.8 0.6 -0.6 -0.3 0.5 0.6 0.6 1.8 0.7 0.2 0.5 1.0
Arm fat-free mass (right) 0.1 0.3 2.1 -0.5 -0.0 0.1 0.6 -0.5 -0.9 -0.3 0.8 -0.9 -0.2 0.1 -0.3 1.5 -0.3 -0.2 -0.4 0.1
Exposure to tobacco smoke outside home 0.8 1.1 2.4 -0.9 1.1 0.4 -1.3 -0.9 -0.4 -1.0 1.1 0.4 -0.2 -1.6 0.8 -1.5 -1.4 -0.7 -1.0 -1.4
Comparative body size at age 10 0.8 2.1 4.2 -1.8 -0.6 -0.6 -2.0 -1.8 -1.9 -1.9 0.1 -0.2 -0.4 -1.9 0.1 -1.2 -1.8 -1.1 -1.9 -2.0
Number of full brothers 1.0 1.3 6.5 1.0 2.6 1.3 0.7 1.0 0.8 0.8 0.5 -0.5 2.2 -0.5 -0.8 1.2 0.3 0.8 1.0 0.4
Worry too long after embarrassment 0.6 1.0 2.6 -0.4 -1.6 -0.8 -0.9 -0.4 -0.4 -0.5 -1.1 0.7 -1.6 -0.4 -1.4 -1.5 -0.3 -1.5 -0.4 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 1.3 0.1 -0.4 -0.6 -0.1 0.1 0.7 0.1 -1.1 0.2 -0.4 -0.4 0.5 -0.8 0.4 -0.4 -0.4 -0.0
Wheeze or whistling in the chest in last year 0.7 1.3 2.9 1.5 0.3 1.2 1.5 1.5 1.5 1.4 -0.8 0.1 -0.4 1.1 -0.1 0.6 1.4 -0.0 1.7 1.5
Number of children fathered 1.2 1.4 10.1 -0.2 3.2 2.5 -0.2 -0.2 -0.8 -0.1 -0.3 0.7 1.6 -0.8 1.2 1.0 -0.5 -0.2 -0.2 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.0 0.9 0.2 0.4 1.3 0.9 0.8 0.9 1.3 -0.4 0.5 1.4 -0.5 1.4 1.3 0.2 0.9 1.4
Age at first live birth 0.5 0.9 2.2 1.0 -0.9 -1.2 0.9 1.0 1.1 1.1 -0.3 1.5 0.9 0.2 0.3 1.2 0.9 0.8 0.9 1.0
Pulse wave peak to peak time 0.2 0.2 0.9 -0.2 0.9 -0.2 -0.1 -0.2 0.5 -0.2 -0.8 0.8 0.4 -0.3 -0.3 0.5 -0.5 0.2 -0.1 -0.2
Health satisfaction 0.2 0.2 0.9 -0.5 -0.3 0.4 -0.2 -0.5 -1.0 -0.4 -0.6 0.1 -0.8 0.0 0.7 -0.4 0.0 -0.7 -0.3 -0.3
Shortness of breath walking on level ground 1.3 1.6 4.2 1.9 0.5 0.7 1.5 1.9 0.9 1.8 1.1 0.0 0.1 1.1 -0.7 0.0 1.8 0.2 2.1 1.5
Qualifications: College or University degree 0.6 1.8 5.9 -1.5 -1.3 -2.2 -1.3 -1.5 -2.4 -1.3 1.5 -0.5 -0.8 -0.5 0.2 -0.6 -1.3 0.3 -1.8 -1.2
Eye problems/disorders: None of the above 0.2 0.3 0.8 -0.3 -0.3 -0.6 -0.9 -0.3 -0.5 -0.3 0.4 -0.7 -0.2 -0.5 -0.0 -0.8 -0.2 -0.3 -0.7 -0.5
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.3 -0.0 0.7 1.2 0.9 -0.0 -0.2 0.0 0.8 0.5 -0.8 1.1 0.1 0.6 0.7 -0.7 0.1 0.7
Emphysema/chronic bronchitis 0.8 0.9 3.6 0.8 -1.1 -0.7 0.5 0.8 -0.6 0.7 0.1 1.9 -1.0 1.0 -1.5 -0.6 0.6 1.0 1.0 0.6
Medication for pain relief, constipation, heartburn 0.5 0.8 4.1 0.1 1.2 1.9 0.1 0.2 0.7 0.3 1.5 0.2 0.9 -0.7 2.0 -0.4 0.1 -0.5 0.2 0.2
Neck or shoulder pain in last month 0.3 0.4 2.7 -0.0 0.2 1.6 -0.3 -0.0 1.1 -0.1 -0.7 0.0 -0.7 -0.4 0.9 -0.8 -0.1 -0.9 0.2 -0.2
Medication: Blood pressure 1.6 2.8 5.8 2.2 0.9 0.3 2.3 2.2 0.9 2.2 -0.5 -1.3 0.2 2.0 -1.0 1.4 2.1 1.0 2.4 2.3
Angina (self-reported) 0.6 0.8 2.7 1.3 1.0 -0.0 0.5 1.3 -0.3 1.1 1.4 -1.2 0.4 0.0 -1.6 0.6 0.5 0.4 1.1 0.6
Migraine (self-reported) 0.7 0.8 2.2 -1.0 -0.9 0.1 -0.9 -1.0 -1.3 -0.9 -0.6 -1.3 -0.8 -0.5 0.5 -0.6 -0.8 -1.5 -1.1 -0.6
Medication: Ibuprofen 0.3 0.3 1.0 -0.8 -0.7 0.1 -0.4 -0.8 0.1 -0.8 0.0 0.4 -1.0 0.5 0.1 -0.8 -0.2 -0.8 -0.7 -0.4
Medication: Allopurinol 1.0 1.3 4.7 0.9 -0.0 -0.5 1.0 0.9 1.6 0.9 0.1 -0.3 2.1 0.8 0.2 1.8 0.8 2.2 1.0 0.9
Medication: Omeprazole 3.5 4.2 10.4 2.4 -0.4 -0.3 2.2 2.4 1.7 2.5 0.3 -1.6 2.7 2.0 -0.3 2.2 2.4 3.2 2.0 2.4
Medication: Seretide 50 evohaler 0.3 0.4 1.4 0.6 1.0 0.6 -0.1 0.6 0.2 0.5 0.6 1.2 0.9 -0.8 0.4 -0.3 -0.1 0.2 0.7 -0.0
Mean time to correctly identify matches 0.9 1.7 4.6 1.4 0.1 0.6 1.6 1.4 1.9 1.4 -1.4 0.1 0.1 2.1 -0.3 0.5 1.9 0.8 1.6 1.7
Heart disease (mother) 1.8 2.2 5.1 1.6 -0.5 -1.9 0.8 1.6 1.9 1.5 0.6 -1.8 1.7 0.3 -2.0 1.5 0.8 2.2 1.4 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.3 0.8 0.0 0.1 0.6 0.8 0.0 0.8 -0.3 -0.5 1.0 0.4 -0.4 0.8 0.7 1.1 0.4 0.7
Whole body fat mass 0.3 1.2 5.4 0.6 2.2 1.6 1.5 0.6 0.7 0.7 -0.8 -0.4 0.6 0.6 0.4 2.3 0.7 0.3 0.6 1.1
Leg fat mass (right) 0.3 1.1 4.5 0.6 2.1 1.8 1.5 0.6 0.6 0.6 -0.1 -0.5 0.4 0.6 0.4 2.0 0.6 0.2 0.6 1.0
Arm predicted mass (right) 0.1 0.5 2.2 -0.8 -0.5 -0.4 0.2 -0.8 -1.5 -0.6 0.7 -0.5 -0.5 -0.1 -0.5 1.1 -0.7 -0.3 -0.8 -0.2
Pulse rate, automated reading 1.8 5.8 28.5 1.6 -0.5 0.4 3.6 1.6 -0.2 1.9 1.5 2.7 -2.7 5.3 -0.1 1.3 3.7 1.4 1.9 3.4
Alcohol intake frequency. 0.1 0.2 2.3 -0.4 -0.2 -0.4 -0.0 -0.4 0.3 -0.3 -1.5 0.5 0.1 0.2 -0.1 0.7 -0.2 -0.1 -0.5 -0.1
Comparative height size at age 10 0.1 0.6 2.7 -0.2 -1.1 -0.1 0.3 -0.2 -0.9 -0.2 1.6 -1.6 0.3 0.8 0.0 1.2 0.2 0.3 -0.3 0.4
Number of full sisters 0.4 0.5 2.5 0.1 0.4 -0.6 0.0 0.1 -0.2 0.0 -1.5 1.1 0.3 -0.2 -1.6 1.1 -0.3 0.0 0.2 0.0
Suffer from ‘nerves’ 2.2 3.4 10.6 -1.5 0.3 -0.4 -2.3 -1.5 -0.2 -1.8 -3.2 0.8 -1.6 -2.4 -0.7 -2.7 -2.2 -2.2 -1.7 -2.3
Overall health rating 0.1 0.3 1.7 0.4 1.3 0.6 0.4 0.4 0.2 0.4 -0.3 -0.6 -0.0 -0.4 -1.0 0.5 -0.2 -0.0 0.9 0.1
Chest pain or discomfort 0.4 0.6 4.0 -0.6 -0.1 -0.3 -0.3 -0.6 -0.6 -0.6 0.8 -0.6 -2.0 0.2 0.9 -1.4 0.3 -1.1 -0.4 -0.3
Had major operations 0.6 0.7 1.9 0.6 -0.3 -0.2 1.3 0.6 0.2 0.8 -0.8 -0.5 0.5 1.4 0.5 1.2 1.0 1.0 0.5 1.2
Age at last live birth 0.2 0.3 1.3 -0.1 -1.1 -1.1 0.2 -0.1 -0.2 0.1 0.5 0.5 0.1 0.4 0.4 0.8 0.2 0.5 -0.1 0.3
Family relationship satisfaction 0.3 0.4 1.6 0.7 -0.4 0.5 0.1 0.8 1.3 0.7 0.4 -0.2 1.0 -0.5 -0.6 -0.3 0.2 0.4 0.8 0.1
Leg pain on walking 1.0 1.3 3.7 1.1 -1.1 -0.3 1.3 1.1 -0.2 1.0 0.6 1.7 -0.4 1.9 -0.5 0.7 1.5 1.4 1.2 1.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 1.0 -0.2 0.1 -0.3 0.1 -0.2 0.4 -0.2 -1.0 -0.7 -0.7 -0.2 -0.4 0.0 -0.2 -0.9 -0.2 -0.0
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.2 -0.5 -0.6 0.1 -0.4 -0.5 -0.6 -0.5 -0.1 -0.2 0.7 -0.7 1.1 0.2 -0.4 0.6 -0.5 -0.6
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 9.4 -0.3 -3.1 -2.6 -0.9 -0.3 0.2 -0.3 -1.5 1.0 -0.4 0.4 -1.3 -0.3 -0.1 0.6 -0.7 -0.3
Medication: Aspirin 0.6 0.8 3.0 -0.0 -0.1 -1.0 1.0 -0.0 -0.6 -0.1 -1.5 -0.9 -1.0 1.5 -1.7 1.0 0.3 1.1 0.1 0.5
Supplements: Vitamin C 0.9 1.1 3.4 -1.4 -0.3 0.4 -1.0 -1.4 -0.3 -1.1 -1.1 -1.2 -0.7 -0.7 1.9 -0.0 -0.8 -1.4 -1.6 -0.7
Knee pain experienced in last month 0.4 0.6 3.2 0.3 0.1 0.2 0.7 0.3 1.8 0.3 -1.4 0.7 0.6 0.5 0.8 1.1 0.5 0.3 0.2 0.6
Hypertension (Self-reported) 0.8 2.1 4.4 1.7 -0.4 -1.3 1.8 1.7 0.6 1.7 -0.1 0.2 0.4 1.5 -2.0 1.8 1.5 1.4 2.1 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.6 2.8 -0.7 -0.5 0.8 -0.6 -0.7 0.4 -0.7 -1.7 -0.6 -0.3 -0.1 1.3 -1.3 -0.3 -0.7 -0.7 -0.6
Illnesses of father: Heart disease 0.6 0.9 3.5 -1.0 1.5 -0.0 -0.8 -1.0 -0.4 -1.0 0.7 -1.9 -0.8 -0.5 0.3 -0.9 -1.0 -0.2 -1.0 -1.0
Illnesses of siblings: Diabetes 0.3 0.4 1.2 -0.2 1.1 0.8 -0.7 -0.2 -0.5 -0.3 0.8 -1.0 -0.3 -0.8 0.0 -0.8 -0.5 -1.0 -0.2 -0.5
Smoking status: Previous 1.3 2.0 7.9 -1.1 2.1 2.8 -1.3 -1.2 -0.9 -1.4 -0.2 -1.4 -0.9 -0.7 1.5 -1.5 -1.0 -1.8 -0.7 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 3.6 -0.3 -0.9 -0.0 -0.8 -0.3 -0.1 -0.4 -1.0 -0.2 -0.8 -1.1 0.1 -0.9 -0.5 -1.9 -0.5 -0.6
Whole body fat-free mass 0.1 0.5 3.7 -0.2 -0.6 -0.2 1.2 -0.2 -0.9 0.1 0.7 -0.6 -0.1 0.9 -0.2 1.9 0.3 0.2 -0.1 0.7
Leg fat-free mass (right) 0.1 0.5 3.7 -0.1 -0.0 0.3 1.3 -0.1 -0.8 0.2 0.6 -0.1 -0.1 0.8 0.4 1.9 0.4 0.0 0.0 0.8
Arm fat percentage (left) 0.5 2.0 8.6 0.9 2.9 2.3 1.9 0.8 1.1 1.0 -1.4 0.2 0.5 0.8 0.8 2.5 1.0 0.2 0.9 1.4
Average weekly red wine intake 0.9 1.3 3.9 0.7 0.5 0.1 1.2 0.7 1.8 0.7 -1.6 1.2 0.3 1.6 -0.5 1.7 0.4 2.0 1.0 1.0
Handedness (chirality/laterality): Left-handed 1.3 1.5 7.1 0.7 -1.5 -2.5 0.0 0.7 -0.9 0.5 0.7 2.7 -0.7 0.1 -2.5 -0.5 0.5 0.1 0.6 0.1
Mood swings 0.2 0.3 3.6 -0.0 -0.3 0.3 0.0 -0.0 -0.3 -0.1 -0.2 -1.9 -0.5 0.4 -0.3 -0.6 0.3 0.0 -0.1 0.0
Loneliness, isolation 0.1 0.2 1.2 0.3 0.2 -0.0 -0.3 0.3 0.2 0.1 0.4 0.7 -0.5 -0.7 0.1 -1.1 -0.2 -0.4 0.4 -0.4
Long-standing illness, disability or infirmity 1.3 2.0 4.5 1.5 1.6 0.9 1.5 1.5 2.1 1.6 -0.3 -0.3 1.8 0.6 0.7 1.9 1.3 1.2 1.7 1.5
Ever had bowel cancer screening 1.2 1.4 6.1 -0.0 1.3 1.8 1.1 -0.0 -0.0 0.2 1.4 -2.5 0.1 1.5 1.6 1.2 0.7 1.0 -0.0 1.0
Diabetes diagnosed by doctor 2.9 4.7 10.8 2.8 1.0 -0.1 2.5 2.8 1.7 2.6 0.1 1.5 2.2 1.4 -2.1 3.3 2.0 2.1 3.0 2.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 2.4 0.1 0.6 0.3 0.4 0.1 0.2 0.2 1.5 1.2 0.4 0.5 -0.5 0.3 0.3 0.5 0.4 0.3
Friendships satisfaction 0.3 0.4 1.2 0.6 0.6 0.3 -0.5 0.6 0.9 0.4 0.9 -1.1 0.9 -0.7 -0.8 -0.6 -0.1 0.4 0.5 -0.3
Qualifications: nursing, teaching 1.5 2.3 13.7 -0.8 -3.7 -3.1 -0.8 -0.8 -2.1 -0.8 0.6 0.7 -1.4 0.1 -1.7 -0.5 -0.7 0.3 -1.1 -0.7
Commuting to job workplace: Walk 0.7 0.8 4.8 0.3 1.8 1.4 0.7 0.3 0.9 0.2 0.5 -2.2 -0.0 0.9 0.0 0.3 0.3 0.5 0.5 0.6
Eye problems/disorders: Cataract 1.4 1.6 3.6 -1.8 -0.2 0.1 -1.6 -1.8 -1.4 -1.8 0.0 0.7 -0.2 -1.0 -0.1 -1.0 -1.9 -0.7 -1.7 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 2.8 0.4 1.1 0.1 0.4 0.4 0.3 0.2 -1.7 -0.7 -0.3 0.1 -1.1 0.5 -0.0 0.2 0.6 0.1
Medication for cholesterol 1.6 2.4 15.9 -1.3 1.4 2.2 -0.8 -1.3 0.4 -1.1 -0.8 -2.3 0.1 -1.1 4.0 -1.1 -0.7 -1.2 -1.5 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 8.1 -0.3 -0.1 -1.4 -0.3 -0.3 -1.2 -0.5 0.1 0.7 -0.9 0.6 -2.8 0.6 -0.4 0.3 -0.1 -0.3
Back pain experienced in last month 0.5 0.7 2.8 -0.9 1.1 0.5 -0.0 -0.9 -0.8 -0.9 0.5 1.7 -1.6 1.1 -0.0 -0.5 -0.2 0.5 -0.2 -0.3
Mineral and other dietary supplements 0.4 0.5 2.2 0.1 0.3 -0.6 -0.3 0.0 -0.2 0.0 0.6 0.7 -1.4 -0.4 -1.5 -1.2 -0.1 -1.1 0.3 -0.3
Breast cancer (self-reported) 0.5 0.6 4.8 -0.2 1.4 1.3 -0.1 -0.2 0.2 -0.0 -0.5 -0.4 0.5 -0.4 2.2 -0.1 -0.0 0.1 -0.2 -0.0
Asthma (self-reported) 1.1 2.2 4.1 1.8 1.0 1.8 1.9 1.8 1.3 1.8 -0.0 0.1 1.1 1.3 0.6 1.8 1.7 0.7 1.7 2.0
Osteoporosis (self-reported) 0.3 0.3 1.5 -0.3 1.0 0.8 -0.6 -0.3 1.2 -0.5 0.1 -0.7 0.6 -0.2 0.2 -0.6 -0.4 -0.2 -0.2 -0.5
Osteoarthritis (self-reported) 0.8 1.0 2.5 0.6 -0.2 -0.1 1.2 0.6 1.0 0.8 1.5 -0.7 0.7 1.4 1.1 0.7 1.2 1.6 0.9 1.1
Medication: Aspirin 0.6 0.8 2.9 0.1 -0.1 -0.8 1.2 0.1 -0.5 0.1 -1.5 -0.5 -1.0 1.7 -1.5 1.3 0.5 0.8 0.1 0.7
Medication: Gliclazide 1.3 1.5 4.4 1.1 2.0 0.9 1.4 1.1 0.8 1.0 1.0 -1.8 1.0 0.7 -0.1 2.1 0.8 0.9 1.1 1.2
Illnesses of father: None of the above (group 1) 1.3 1.6 5.8 -1.8 -0.3 0.6 -1.1 -1.7 -0.5 -1.6 0.3 2.4 -0.9 -0.2 0.9 -0.4 -0.8 -2.2 -1.6 -1.0
Smoking status: Current 0.3 0.4 2.5 -0.8 -0.3 -0.6 -0.1 -0.8 -0.5 -0.5 1.6 -0.4 0.4 0.3 0.4 0.5 -0.3 0.9 -1.1 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.0 -0.8 -0.8 0.2 -0.5 -0.8 0.4 -0.8 -0.2 0.4 1.0 0.0 0.9 0.5 -0.4 0.8 -0.9 -0.5
Whole body water mass 0.1 0.5 3.9 -0.1 -0.5 -0.1 1.3 -0.1 -0.8 0.1 0.7 -0.6 -0.1 0.9 -0.1 2.0 0.3 0.3 0.0 0.8
Leg predicted mass (right) 0.1 0.5 4.0 0.0 -0.0 0.3 1.4 0.0 -0.7 0.3 0.6 -0.0 -0.0 0.8 0.3 2.0 0.5 0.0 0.1 0.9
Arm fat mass (left) 0.4 1.6 7.3 0.8 2.2 1.6 2.0 0.8 0.7 0.9 -0.8 -0.1 0.3 1.1 0.2 2.7 1.0 0.5 1.0 1.5
Number of self-reported non-cancer illnesses 0.3 0.4 2.0 0.0 -0.0 0.1 0.9 0.0 0.4 0.1 0.1 -0.9 -0.1 1.3 0.2 1.1 0.6 1.4 0.4 0.6
Average weekly champagne plus white wine intake 0.5 0.7 3.1 -0.6 -1.1 -0.5 -0.2 -0.6 -1.7 -0.5 -0.1 -1.0 -1.8 -0.1 -0.4 -0.6 -0.1 -1.5 -0.5 -0.3
Miserableness 0.2 0.3 1.7 -0.3 0.3 0.3 -0.3 -0.3 -0.6 -0.4 -0.4 0.7 -0.9 -0.4 -0.1 -1.3 -0.5 0.0 -0.1 -0.6
Guilty feelings 0.4 0.7 2.0 -0.2 0.3 0.3 -1.3 -0.2 0.3 -0.4 -1.1 0.4 -0.1 -1.4 -0.9 -1.1 -0.9 -1.3 -0.1 -1.0
Wears glasses or contact lenses 0.5 0.6 2.5 -0.8 -0.2 -0.1 0.3 -0.8 -0.9 -0.6 -0.2 1.4 -0.7 1.6 0.6 0.5 0.2 1.0 -0.8 0.2
Ever taken oral contraceptive pill 0.4 0.5 1.4 0.7 0.1 0.8 0.7 0.7 0.3 0.6 0.5 -0.9 -0.6 1.1 0.3 0.1 1.2 -0.2 0.9 0.9
Hearing aid user 0.2 0.2 1.3 -0.1 0.6 0.7 0.5 -0.1 0.2 -0.2 -0.8 -0.7 -1.1 0.7 0.0 -0.4 0.1 0.1 0.2 0.1
Mother’s age at death 0.6 0.8 3.2 -0.0 -1.2 -1.4 -0.6 -0.0 0.7 -0.1 -1.5 -0.9 0.7 -0.4 -1.8 1.1 -0.7 0.5 -0.3 -0.2
Financial situation satisfaction 0.2 0.3 1.1 -0.6 -0.8 -0.8 -0.3 -0.6 0.2 -0.4 0.3 -1.0 0.3 -0.2 -0.2 0.8 -0.6 0.2 -0.3 -0.2
Tinnitus: Yes, now most or all of the time 0.2 0.3 2.3 -0.1 0.4 -0.5 -0.5 -0.1 -0.9 -0.2 1.5 0.4 -0.0 -0.4 -0.6 0.1 -0.3 -0.5 -0.0 -0.3
Commuting to job workplace: Public transport 0.8 0.9 5.7 0.2 -0.4 -1.0 0.5 0.2 -0.1 0.4 -1.5 0.4 -2.4 1.3 -0.9 -1.0 0.9 -1.0 0.4 0.7
Eye problems/disorders: Glaucoma 1.3 1.6 5.4 -1.8 0.7 0.2 -1.0 -1.8 -0.5 -1.7 -0.9 -2.3 -0.5 -0.7 1.3 -0.4 -1.5 -0.3 -1.6 -1.3
Medication: Blood pressure 1.0 2.0 13.6 0.9 -1.5 -2.5 0.1 0.9 -1.0 0.7 0.6 2.4 -0.3 0.3 -3.7 0.5 0.1 0.7 1.0 0.2
Pain type(s) experienced in last month: Hip pain 0.3 0.3 3.3 -0.1 0.8 -0.0 -0.2 -0.1 0.7 -0.1 1.8 -0.9 -0.2 -0.3 0.2 -0.2 -0.2 0.3 0.1 -0.3
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.1 0.4 -0.2 0.6 0.8 0.4 0.5 0.5 -0.7 -1.4 1.2 1.0 1.5 0.9 0.8 1.4 0.3 0.9
High cholesterol (Self-reported) 0.9 1.7 4.5 1.5 -0.3 -0.4 1.6 1.5 -0.0 1.3 0.3 -0.2 -0.6 2.0 -2.1 1.6 1.5 0.7 1.5 1.6
Medication: Bendroflumethiazide 0.3 0.4 2.7 -0.7 0.4 0.2 -0.6 -0.6 -0.3 -0.7 0.2 -1.6 0.1 -0.4 0.1 -0.5 -0.7 0.6 -0.5 -0.7
Medication: Paracetamol 0.3 0.4 2.7 0.2 -0.5 -0.4 0.4 0.2 -0.3 0.2 -1.6 0.8 -0.5 1.1 -0.6 0.8 0.6 0.3 0.1 0.6
Medication: Lisinopril 0.6 0.7 2.9 -0.8 -0.4 -1.1 -0.3 -0.8 -1.2 -0.7 -0.1 -1.4 -1.7 -0.9 -0.2 -0.6 -0.7 -0.5 -0.2 -0.9
Medication: Atorvastatin 2.5 3.1 6.7 1.9 -0.4 -0.9 2.6 1.9 0.4 1.9 0.8 -0.5 -0.0 2.6 -2.3 2.3 2.0 1.3 1.8 2.4
Illnesses of father: High blood pressure 2.4 2.9 7.2 2.7 -0.1 -0.7 1.5 2.7 1.2 2.5 0.2 0.3 1.2 0.8 -2.0 0.8 1.7 2.2 2.7 1.8
Alcohol drinker status: Never 1.1 1.3 3.3 -1.6 -0.7 -0.5 -1.7 -1.6 -1.5 -1.5 -0.1 0.5 -0.2 -0.9 -0.3 -0.5 -1.8 -0.0 -1.6 -1.5
Ever smoked 1.7 3.0 4.7 -2.0 2.0 2.0 -2.0 -2.0 -1.1 -2.0 1.1 -1.0 -0.6 -1.5 1.9 -2.2 -2.1 -0.8 -1.6 -2.2
Basal metabolic rate 0.1 0.6 4.2 0.1 -0.1 0.1 1.4 0.1 -0.7 0.3 0.6 -0.5 -0.0 0.9 -0.0 2.1 0.4 0.3 0.2 0.9
Leg fat percentage (left) 0.2 0.8 4.9 0.6 2.2 1.6 1.1 0.6 0.4 0.5 -0.6 -0.1 0.4 0.2 0.1 1.6 0.4 0.1 0.5 0.7
Arm fat-free mass (left) 0.1 0.4 3.3 -0.2 -0.3 -0.4 0.9 -0.2 -0.8 -0.0 0.7 -0.6 0.1 0.6 -0.6 1.8 -0.0 0.6 -0.0 0.4
Number of operations (self-reported) 1.2 1.7 3.9 1.1 0.4 1.2 1.9 1.1 1.1 1.2 0.5 -2.0 0.4 1.9 0.7 1.5 1.8 1.0 1.1 1.8
Average weekly beer plus cider intake 0.6 0.9 2.8 -0.8 -0.6 -0.1 -1.0 -0.8 0.2 -0.8 -0.2 1.3 -0.8 -1.6 0.2 -1.1 -1.1 -1.7 -0.5 -1.1
Irritability 0.5 0.9 1.7 1.1 -1.3 -1.1 0.9 1.1 0.3 1.1 0.7 -0.1 -0.9 0.6 -1.3 -0.4 1.1 0.3 1.3 0.8
Risk taking 0.8 1.2 5.8 -0.6 1.6 0.8 -0.5 -0.6 0.1 -0.6 0.5 -2.4 1.9 -1.4 0.9 1.1 -1.0 0.2 -0.6 -0.7
Ever had prostate specific antigen (PSA) test 1.1 1.3 3.9 0.8 1.1 1.4 1.3 0.8 2.0 0.9 -2.0 -0.4 -0.8 1.2 0.5 0.2 1.3 -0.8 0.6 1.2
Fractured/broken bones in last 5 years 0.8 1.0 2.9 0.4 0.5 0.8 1.1 0.3 0.8 0.6 0.1 -1.7 1.3 1.1 1.3 1.6 0.8 1.4 0.5 1.0
Age started oral contraceptive pill 2.1 2.6 5.9 1.4 -1.5 -1.5 1.3 1.4 2.2 1.6 -2.3 0.1 1.9 1.4 -0.3 2.4 1.4 2.0 1.1 1.7
Diastolic blood pressure, automated reading 0.5 1.6 7.0 -0.2 -1.9 -1.4 1.2 -0.2 -1.3 -0.2 -0.7 -0.5 -2.3 2.6 -1.4 0.4 0.9 1.1 0.2 0.8
Ever depressed for a whole week 2.8 3.5 7.7 2.5 -0.1 0.8 2.2 2.5 1.8 2.8 -0.8 0.1 1.7 1.3 1.2 1.4 2.6 1.5 2.6 2.5
Unable to work because of sickness or disability 0.8 1.1 2.7 1.2 1.5 1.6 1.2 1.2 1.5 1.2 -0.6 0.1 0.6 -0.2 1.5 0.1 0.9 -0.1 1.2 0.8
Commuting to job workplace: Cycle 1.5 1.8 5.0 -1.3 2.2 0.7 -1.7 -1.3 -1.5 -1.4 -0.2 1.2 0.6 -1.9 0.6 -0.4 -1.8 -0.9 -1.1 -1.7
Myopia 0.4 0.6 2.5 -0.0 1.1 1.5 -0.4 -0.0 0.0 -0.0 -0.5 -0.9 0.8 -1.0 1.6 -0.8 -0.3 0.1 -0.2 -0.4
Vascular/heart problems diagnosed by doctor 0.5 1.2 5.1 -1.4 -0.0 1.0 -1.3 -1.4 0.0 -1.3 -0.1 0.5 0.1 -1.1 2.2 -0.9 -1.1 -1.0 -1.5 -1.1
Cholesterol lowering medication 1.4 2.1 5.5 1.4 -1.4 -1.6 1.5 1.4 0.2 1.3 0.9 1.3 0.2 1.8 -2.3 1.5 1.3 2.2 1.5 1.3
Medication: Omeprazole (e.g. Zanprol) 4.0 4.8 10.2 2.7 -0.9 -0.7 2.5 2.7 1.8 2.8 -0.2 -0.3 2.6 2.4 -0.6 2.4 2.7 3.2 2.3 2.8
Pain experienced in last month 0.2 0.4 0.9 0.9 -0.6 -0.4 0.6 0.9 0.6 1.0 0.3 -0.8 0.7 0.1 0.1 0.1 0.6 0.7 0.7 0.7
Supplements: Calcium 4.2 4.7 10.8 -3.1 -0.9 -0.6 -1.9 -3.1 -2.5 -3.0 -1.6 -1.9 -2.5 -0.6 1.2 -2.0 -2.1 -1.4 -3.3 -2.2
Basal cell carcinoma (self-reported) 0.5 0.6 1.4 -0.5 -1.2 -1.0 -0.9 -0.5 -0.6 -0.6 0.0 -0.3 -0.9 -0.5 -1.0 -1.0 -0.4 -1.1 -0.5 -0.7
Heart attack/myocardial infarction (self-reported) 1.2 1.5 8.4 1.4 -0.1 -1.5 0.7 1.4 0.5 1.4 0.1 -2.0 -0.3 0.9 -2.9 0.7 0.9 0.6 1.0 1.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 3.3 -1.2 -0.4 -0.5 -1.3 -1.2 -1.6 -1.2 -1.8 -1.2 -0.2 -0.6 -0.2 0.5 -1.2 -0.1 -1.3 -0.9
Heart disease (siblings) 0.5 0.6 1.7 0.9 0.5 -0.7 0.7 0.9 0.5 0.8 0.1 0.4 0.6 0.9 -1.2 0.5 0.8 1.3 0.9 0.7
Alcohol drinker status: Previous 0.3 0.3 2.1 0.0 1.1 0.7 -0.4 0.0 1.0 -0.1 -1.4 0.0 -0.2 0.0 0.2 -0.4 -0.1 -0.2 0.3 -0.2
Pack years of smoking 0.2 0.3 2.0 -0.1 -0.3 -1.0 -0.5 -0.1 0.2 -0.1 -0.1 -1.4 -0.7 -0.1 -1.2 -0.1 -0.3 -0.1 0.2 -0.3
Impedance of whole body 0.1 0.6 2.2 0.6 0.1 -0.3 -1.2 0.6 1.4 0.4 -0.4 -0.7 1.1 -1.5 0.2 -1.2 -0.1 -0.2 0.2 -0.3
Leg fat mass (left) 0.2 0.9 4.2 0.6 1.9 1.4 1.5 0.6 0.4 0.6 -0.2 -0.5 0.3 0.5 0.1 2.0 0.6 0.2 0.6 1.0
Arm predicted mass (left) 0.1 0.4 3.3 -0.2 -0.2 -0.3 0.8 -0.2 -0.9 -0.0 0.8 -0.8 0.3 0.3 -0.5 1.8 -0.1 0.4 -0.1 0.4