Hub : Genes

METTL6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1090	0.0474	4.8e-03	0.033	NA	0.019	NA	0.043	1.2e-03	NA	1.1e-02	NA	2.6e-04
2	GTEx	Brain Cerebellar Hemisphere	0.4070	0.1060	8.1e-04	0.061	NA	0.197	NA	0.040	1.2e-02	NA	8.8e-06	NA	3.4e-02
3	GTEx	Brain Cerebellum	0.2900	0.1070	3.2e-03	0.152	NA	0.069	NA	0.106	3.0e-05	NA	4.3e-03	NA	4.8e-04
4	GTEx	Cells Transformed fibroblasts	0.1960	0.0510	1.6e-07	0.099	NA	0.121	NA	0.138	7.0e-08	NA	2.2e-09	NA	1.7e-10
5	GTEx	Esophagus Muscularis	0.1670	0.0630	3.0e-03	0.093	NA	0.034	NA	0.086	2.9e-06	NA	3.5e-03	NA	6.9e-06
6	GTEx	Skin Not Sun Exposed Suprapubic	0.2480	0.0760	1.7e-03	0.047	NA	0.178	NA	0.174	1.4e-03	NA	4.7e-10	NA	7.5e-10
7	GTEx	Skin Sun Exposed Lower leg	0.1450	0.0520	1.7e-03	0.122	NA	0.077	NA	0.113	2.6e-10	NA	6.5e-07	NA	1.4e-09
8	GTEx	Whole Blood	0.1340	0.0430	7.7e-04	0.002	NA	-0.002	NA	-0.002	1.8e-01	NA	5.5e-01	NA	5.2e-01
9	YFS	Blood	0.0350	0.0137	3.7e-04	0.003	0.009	0.010	0.01	0.004	4.1e-02	3.4e-04	2.0e-04	0.00023	1.5e-02
10	TCGA	Colon Adenocarcinoma	0.2290	0.0740	5.4e-05	0.017	0.110	0.094	NA	0.043	3.4e-02	6.7e-07	4.5e-06	NA	1.7e-03
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0415	0.0229	7.7e-04	0.004	0.023	0.000	NA	0.012	9.3e-02	1.0e-03	2.7e-01	NA	1.5e-02
12	TCGA	Brain Lower Grade Glioma	0.0475	0.0284	7.7e-03	0.008	0.009	0.002	NA	0.004	4.0e-02	3.1e-02	1.7e-01	NA	1.2e-01
13	TCGA	Lung Squamous Cell Carcinoma	0.0508	0.0264	5.5e-03	-0.002	0.001	-0.002	NA	-0.002	6.9e-01	2.1e-01	1.0e+00	NA	6.1e-01
14	TCGA	Prostate Adenocarcinoma	0.0447	0.0254	1.9e-03	0.023	0.018	0.004	NA	0.018	1.7e-03	5.2e-03	1.0e-01	NA	4.9e-03
15	TCGA	Rectum Adenocarcinoma	0.5500	0.1390	8.5e-03	-0.008	-0.003	0.003	NA	-0.006	5.3e-01	3.7e-01	2.7e-01	NA	4.6e-01
16	TCGA	Stomach Adenocarcinoma	0.2140	0.0870	1.2e-03	0.056	0.050	0.033	NA	0.057	6.4e-05	1.7e-04	1.8e-03	NA	6.0e-05
17	TCGA	Thyroid Carcinoma	0.0630	0.0320	2.0e-04	0.040	0.048	0.055	NA	0.059	9.1e-05	1.8e-05	4.2e-06	NA	2.1e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Bipolar Disorder (2018)	0.3	0.4	2.0	0.4	-0.5	0.2	0.9	0.4	0.1	0.7	-0.3	0.8	-0.6	0.2	0.2	0.1	0.8	-1.4	0.2	0.9
Bipolar Disorder or Schizophrenia	0.1	0.1	1.5	0.1	-0.0	-0.0	0.2	0.1	-0.0	0.1	-0.3	0.7	-0.4	-0.4	-0.1	-0.0	-0.0	-1.2	-0.0	0.3
Depressed Affect (Nagel 2018)	0.4	0.8	2.9	0.8	0.4	0.4	0.7	0.8	1.2	0.7	-0.5	-1.2	1.3	0.7	0.2	0.9	0.7	1.7	0.7	0.7
Depression (Nagel 2018)	0.4	0.6	3.8	0.2	0.1	0.3	-0.6	0.2	1.6	-0.0	-2.0	0.1	0.0	-0.7	0.5	-1.2	-0.2	-0.0	0.3	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.8	0.2	-1.4	-0.7	0.7	0.1	0.9	0.4	0.0	1.3	-0.5	1.3	1.0	-0.3	1.1	0.5	-0.0	0.8
Neuroticism (Nagel 2018)	0.1	0.3	1.3	0.2	-0.5	-0.4	-0.5	0.2	0.9	0.1	-1.1	-0.2	-0.3	-0.4	-0.7	-1.1	-0.2	0.4	0.2	-0.4
Schizophrenia (2018)	0.1	0.1	0.5	-0.2	0.4	-0.2	-0.5	-0.3	-0.1	-0.4	-0.1	0.3	-0.1	-0.6	-0.3	-0.1	-0.7	-0.4	-0.3	-0.4
Schizophrenia vs Biploar Disorder	1.1	1.4	3.2	1.6	-1.0	-0.7	1.2	1.7	1.2	1.5	1.1	0.7	0.5	1.1	-0.8	0.1	1.4	1.2	1.8	1.2
Worry (Nagel 2018)	1.2	2.6	10.0	-1.1	0.6	0.1	-2.2	-1.1	0.6	-1.4	-2.3	0.5	-1.7	-2.0	-0.2	-3.2	-1.8	-1.7	-1.3	-2.1
Alzheimer’s Disease (in mother)	0.4	0.5	2.0	-0.0	0.5	1.4	0.8	-0.0	0.5	0.1	-0.5	1.1	-0.2	1.0	1.3	0.5	0.7	-0.4	-0.1	0.6
Alzheimer’s Disease (in father)	1.1	1.1	4.8	0.8	-1.6	-2.2	0.8	0.8	-0.4	1.0	1.2	1.0	0.2	1.1	-0.7	0.2	0.8	1.8	0.6	0.9
Alzheimer’s Disease (including proxy)	0.3	0.5	2.2	-0.3	-1.2	-0.5	0.0	-0.2	-1.0	-0.3	1.5	1.0	-0.8	0.7	-0.1	-0.8	0.0	0.3	-0.4	-0.1
Crohns Disease (2017)	1.0	2.1	5.0	-1.9	-0.1	0.2	-1.6	-2.0	-1.3	-1.7	-1.3	-1.2	-0.2	-1.4	1.5	-0.8	-1.8	-1.4	-2.2	-1.6
Irritable Bowel Disease (IBD)	0.2	0.6	2.8	-0.8	0.8	0.6	-0.5	-0.6	0.3	-0.5	-0.9	-1.7	0.1	-0.4	1.5	-0.2	-0.6	-0.4	-0.7	-0.3
Ulcerative Colitis (UC)	0.5	0.9	3.1	0.8	1.6	0.8	0.7	1.1	1.8	1.1	-0.2	-1.3	0.7	0.3	0.7	0.4	0.8	0.4	1.1	0.9
Major Depression (MDD)	2.4	2.9	6.3	2.4	1.9	0.3	1.5	2.5	2.2	2.4	0.8	-0.2	2.4	-0.2	0.3	1.7	1.4	1.2	2.4	1.6
Reaction Time	0.8	1.5	3.9	1.4	-0.3	0.9	1.5	1.4	1.6	1.3	-1.3	0.2	-0.8	1.7	0.4	-0.3	2.0	-0.2	1.5	1.6
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	1.2	-0.9	-0.9	1.4	1.1	1.0	1.2	0.1	1.3	0.0	1.6	0.0	0.5	1.6	1.4	0.9	1.4
Breast Cancer	0.5	1.2	3.5	1.6	0.5	0.5	1.0	1.5	0.2	1.6	1.2	1.3	0.0	0.4	0.5	0.4	1.4	0.6	1.9	1.3
Ovarian Cancer	0.3	0.4	1.9	-0.6	0.1	0.2	-0.5	-0.6	-0.8	-0.6	-1.2	1.4	0.1	-0.4	0.3	-0.3	-0.6	-0.3	-0.4	-0.5
Prostate Cancer	0.3	0.5	1.6	0.3	0.3	-0.8	-0.4	0.3	-0.8	0.2	1.1	0.6	0.1	-1.3	-1.1	-0.6	-0.6	-0.1	0.6	-0.6
Age at First Birth	0.3	0.5	1.5	-0.5	-0.3	-0.5	-0.8	-0.5	0.3	-0.4	-1.2	-0.1	0.8	-1.1	0.9	-0.0	-0.7	0.1	-0.8	-0.7
Bipolar Disorder (2011)	0.6	0.5	1.8	-0.9	-0.9	-0.9	-0.5	-0.8	-0.5	-0.6	-1.4	-1.0	0.2	-0.6	0.2	0.5	-0.6	-0.5	-1.0	-0.5
Body Mass Index (BMI) (2010)	0.6	0.8	3.5	-0.6	1.2	1.6	0.1	-1.0	0.2	-0.6	-1.9	-0.3	0.0	0.7	1.4	0.9	0.2	-0.6	-0.9	0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.7	-0.5	-0.2	-0.5	-0.6	-0.6	-0.7	-0.7	0.4	-0.9	-1.0	0.4	-1.1	-0.7	-0.5	-1.3	-0.6	-0.3
Crohns Disease (2012)	0.8	1.3	3.3	-1.6	-0.3	-0.2	-1.2	-1.5	-1.3	-1.3	-0.8	-0.6	-0.7	-1.0	1.1	-1.0	-1.4	-0.9	-1.8	-1.2
Mean Putamen Volume	1.4	1.6	3.2	1.3	-0.9	-1.4	1.7	1.3	0.5	1.4	-0.1	1.8	1.1	0.6	-0.7	1.7	1.2	1.5	1.5	1.2
Fasting Glucose	0.5	0.6	2.3	-0.1	1.4	1.1	-1.0	-0.4	-0.4	-0.3	0.1	1.1	-0.1	-1.1	0.5	-0.6	-0.7	-1.5	-0.7	-0.4
HbA1C	1.1	1.2	5.7	0.5	-1.2	0.2	1.5	0.9	-0.2	0.9	-0.5	1.0	0.2	2.4	0.8	0.5	1.9	1.0	1.2	1.2
HDL Cholesterol	1.0	1.7	6.6	-0.0	-1.7	-2.6	-0.9	0.0	-1.6	-0.2	1.2	-0.6	-2.0	-1.2	-2.0	-1.5	-0.7	-0.7	-0.0	-0.9
LDL Cholesterol	1.5	2.4	5.7	2.1	0.0	0.2	1.8	1.8	0.9	2.0	-0.2	1.7	-0.1	2.0	-1.3	0.5	2.4	0.7	2.2	2.2
Lupus	0.3	0.5	3.3	-0.1	-1.1	-0.5	0.2	-0.0	-0.8	-0.0	1.8	1.1	-0.5	0.4	-0.3	0.7	0.0	-0.6	0.2	0.2
Neuroticism (2016)	0.3	0.4	1.7	-0.4	0.7	-0.2	-1.0	-0.4	-0.3	-0.5	-1.3	-0.9	-0.0	-0.6	-0.7	-0.4	-0.7	-0.6	-0.5	-0.7
Primary Biliary Cirrhosis	1.8	2.6	6.0	1.8	-0.5	-0.4	2.1	1.8	1.8	1.9	0.3	0.7	0.8	2.4	-1.0	1.7	2.1	1.8	1.7	2.2
Rheumatoid Arthritis	1.3	1.8	3.9	-1.1	1.0	-0.1	-1.8	-1.1	-1.5	-1.3	1.1	1.0	-0.6	-1.8	-0.1	-2.0	-1.5	-1.6	-1.2	-1.8
Schizophrenia (2014)	0.1	0.3	1.2	0.1	-1.0	-1.1	0.3	0.2	0.4	0.1	-0.8	0.3	0.1	0.5	-1.0	0.2	0.1	0.6	0.3	0.2
Triglycerides	0.9	1.4	4.2	0.7	2.0	1.8	0.9	0.7	1.7	0.8	-0.5	1.0	2.0	0.7	1.2	0.9	0.8	0.7	0.9	1.0
Type 2 Diabetes (T2D) (2012)	3.4	3.9	10.9	-2.2	1.9	2.0	-2.0	-2.3	-1.1	-2.3	-0.4	-3.3	-0.9	-1.5	1.9	-1.2	-1.9	-2.6	-2.5	-1.7
Ulcerative Colitis	1.2	1.7	5.5	1.9	0.5	-0.4	1.4	1.8	2.4	1.9	-0.4	-0.6	0.9	0.6	-0.6	1.1	1.5	0.5	1.7	1.7
Blood Eosinophil Count	0.1	0.8	2.1	-1.1	1.4	1.1	-0.8	-1.1	-0.1	-0.9	0.7	-0.1	-0.5	-0.7	1.3	-0.7	-0.7	-1.4	-0.8	-0.8
Blood Platelet Count	0.3	3.3	7.3	2.0	1.4	1.1	2.4	2.0	1.9	2.3	-0.2	2.1	-0.4	1.7	2.1	-0.3	2.7	1.4	1.9	2.2
Blood Red Count	0.5	4.6	10.5	2.1	1.5	-0.8	3.0	2.1	1.2	2.2	0.3	-2.0	0.5	3.0	-1.8	3.2	2.7	1.9	2.3	2.9
Blood White Count	0.3	2.4	14.7	0.4	3.8	1.6	-0.1	0.4	2.2	0.6	0.6	-0.3	3.1	-1.6	1.6	1.8	-0.3	-0.1	0.5	0.0
Heel T-Score	0.2	1.8	4.9	1.5	1.3	-0.1	1.9	1.5	-0.1	1.7	-0.1	2.2	-0.1	1.3	0.7	1.0	1.5	1.3	1.8	1.6
BMI	0.1	0.6	3.2	-0.1	1.1	0.7	1.3	-0.1	-0.7	0.1	-0.9	0.7	-0.8	0.9	-0.5	1.8	0.1	0.5	0.4	0.5
Height	0.1	1.1	4.0	0.6	-1.9	-0.7	1.0	0.7	0.8	0.7	-0.7	-0.8	1.2	1.2	-0.2	2.0	0.9	0.6	0.4	1.4
Waist Hip Ratio (WHR)	0.1	0.3	1.9	0.4	0.2	0.3	-0.2	0.4	0.5	0.2	-0.8	1.2	-0.5	0.1	-1.4	-0.5	0.1	-0.2	0.3	-0.0
Systolic Blood Pressure	0.5	2.3	10.0	-0.1	-3.2	-3.1	0.4	-0.1	-1.5	-0.1	0.8	-0.8	-2.5	1.1	-2.7	-0.5	0.2	-0.2	0.3	0.0
Smoking Status	0.7	1.7	4.6	-1.4	1.4	1.5	-1.5	-1.5	-1.3	-1.5	2.1	-1.1	0.2	-0.9	0.9	-0.4	-1.5	-1.0	-1.2	-1.3
Allergy or Eczema	0.3	0.7	4.4	0.3	0.0	0.4	0.7	0.3	1.2	0.6	-0.5	0.9	0.9	0.6	2.1	0.2	0.8	0.8	0.2	0.7
Cardiovascular Disease	0.3	1.1	3.9	1.0	-0.2	-1.4	1.0	1.0	-0.6	0.9	0.2	0.2	-0.1	1.2	-2.0	1.5	0.9	0.8	1.3	1.0
Hypothyroidism (self reported)	0.7	1.7	5.2	-1.4	-1.1	-1.3	-1.8	-1.3	-2.3	-1.4	-0.7	0.2	-0.1	-1.4	-1.1	-0.3	-1.5	-0.9	-1.3	-1.6
Respiratory disease	0.5	1.2	3.1	1.1	0.9	1.8	1.4	1.1	0.5	1.2	0.1	0.7	0.4	1.0	1.0	1.4	1.2	-0.1	1.1	1.5
Type 2 Diabetes (T2D) (2018)	1.5	2.7	5.6	2.1	0.9	-0.3	1.8	2.1	1.0	1.8	-0.7	1.1	1.7	1.0	-2.2	2.3	1.4	1.9	2.4	1.6
Lung FEV1/FVC ratio	0.2	1.2	3.9	-1.4	-0.8	-0.6	-1.2	-1.4	-1.0	-1.2	-0.3	-0.1	0.2	-1.6	0.4	0.3	-1.4	-1.3	-2.0	-1.1
Lung FVC	0.3	1.8	3.6	-1.7	0.1	-0.0	-1.9	-1.7	-1.4	-1.8	1.6	0.5	-0.3	-1.1	0.7	-1.5	-1.7	0.2	-1.5	-1.9
Neuroticism	0.2	0.5	3.2	-0.2	1.2	0.5	-0.5	-0.2	0.9	-0.4	-1.8	-0.4	-0.3	-0.3	-0.1	-0.8	-0.5	0.3	-0.1	-0.6
Chronotype (morning person)	0.7	1.6	5.4	1.4	0.7	-0.1	0.8	1.4	2.3	1.4	0.0	0.6	2.3	0.1	-0.7	1.9	0.8	1.5	1.3	1.0
Hair Pigment	0.0	1.2	6.2	-0.9	-1.2	-1.8	-0.6	-0.9	-1.5	-0.8	0.2	1.0	-2.5	0.3	-1.4	-0.9	-0.6	-0.1	-0.7	-0.7
Tanning	0.1	0.6	4.0	-0.0	1.1	0.9	0.5	-0.0	0.5	-0.0	-1.2	-0.1	0.2	1.0	1.1	-0.3	0.2	2.0	0.5	0.2
Hand grip strength (left)	0.3	0.7	3.3	-0.7	-1.8	-0.9	-0.4	-0.7	-1.4	-0.7	-0.2	0.7	-1.5	0.0	-0.8	-0.6	-0.3	-0.8	-0.6	-0.5
Number of treatments/medications taken	1.2	2.2	6.3	1.1	-0.5	-0.2	2.1	1.1	1.0	1.2	-1.4	-1.5	0.5	2.5	-0.5	2.5	1.6	1.8	1.2	1.9
Average weekly spirits intake	0.4	0.6	3.0	0.3	0.9	-0.4	0.5	0.3	-0.2	0.4	0.7	-1.5	1.0	-0.2	-0.5	1.7	-0.0	0.6	0.3	0.4
Sensitivity / hurt feelings	0.3	0.5	3.1	0.3	-0.3	-0.8	-0.1	0.3	0.9	0.2	-1.8	0.2	0.9	-0.4	-0.9	0.8	-0.2	0.7	0.5	-0.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.1	0.2	-0.1	0.2	-0.6	0.2	0.5	0.0	-1.0	0.6	0.5	-1.0	0.6	-0.7	-0.3	0.1	0.3	-0.6
Hearing difficulty/problems: Yes	0.2	0.4	3.3	0.3	1.8	1.0	0.3	0.3	-0.2	0.3	-0.2	0.5	0.1	-0.2	0.9	0.2	0.3	-0.1	0.2	0.2
Relative age of first facial hair	0.7	1.5	3.3	-1.5	0.6	-0.6	-1.4	-1.5	-0.9	-1.1	0.1	-1.4	0.4	-1.8	1.8	-0.8	-1.5	-0.4	-1.8	-1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.4	0.8	1.7	0.5	0.4	0.8	1.2	0.8	-0.0	-0.1	1.8	-0.1	-0.2	1.5	0.4	0.6	0.9	0.5
Ever used hormone-replacement therapy (HRT)	1.2	1.5	6.3	0.7	0.5	0.5	1.2	0.7	1.4	0.7	0.0	-1.0	2.1	1.5	-0.5	1.9	0.8	2.5	0.5	1.0
Ever had hysterectomy (womb removed)	0.5	0.6	2.9	-0.1	-1.7	-0.6	0.4	-0.1	0.7	0.0	-1.4	-0.1	-0.1	1.3	-0.8	0.6	0.5	0.7	-0.1	0.4
Systolic blood pressure, automated reading	0.6	1.8	6.0	1.0	-2.4	-2.0	1.5	1.0	0.4	1.1	0.0	-1.4	-0.4	1.6	-1.4	1.5	1.1	1.5	1.1	1.3
Eye problems/disorders: Diabetes related eye disease	7.5	8.2	16.0	3.5	-0.8	0.0	4.0	3.5	2.2	3.6	0.6	3.0	1.5	3.2	-0.9	3.3	3.8	1.8	3.7	3.9
Angina	0.7	0.9	2.7	1.3	0.8	-0.1	0.5	1.3	-0.6	1.1	1.5	-1.3	0.4	-0.0	-1.6	0.5	0.5	0.5	1.1	0.6
Medication for hormone replacement therapy	0.1	0.2	0.7	0.1	0.7	0.5	0.5	0.1	-0.0	0.2	0.2	0.2	0.0	0.5	-0.1	0.9	0.3	-0.3	0.2	0.5
Vitamin and mineral supplements	0.7	0.9	7.1	1.1	-0.5	-1.2	0.5	1.1	-0.3	0.8	-0.3	0.7	0.0	0.6	-2.7	0.2	0.5	0.7	1.1	0.6
Supplements: Zinc	1.4	1.5	5.6	-1.1	0.7	1.9	-1.1	-1.1	-0.2	-1.0	-0.4	-1.0	-1.1	-1.1	1.3	-1.3	-1.2	-2.4	-1.2	-0.9
Medication: Co-codamol	0.5	0.6	3.7	-0.0	1.2	0.3	0.1	-0.0	0.6	-0.1	0.4	0.2	1.7	-0.4	0.3	1.2	-0.5	1.9	0.3	-0.3
Medication: Metformin	1.0	1.5	7.5	0.6	1.7	0.5	1.4	0.6	0.8	0.6	-0.4	-0.9	1.4	1.2	-1.2	2.7	0.4	1.5	1.1	1.1
Diabetes (father)	2.0	2.5	7.3	1.7	0.1	-0.6	1.4	1.7	1.8	1.8	-0.4	-1.1	2.7	0.2	-0.1	2.7	1.0	2.4	1.6	1.4
Diabetes (mother)	0.5	0.6	4.8	-0.0	2.2	1.5	-0.1	-0.0	-0.2	-0.2	0.1	0.7	-0.7	-0.4	-0.3	-0.7	-0.4	-0.7	0.4	-0.4
Severe depression (siblings)	0.4	0.5	1.5	-0.8	-0.3	-0.8	-0.5	-0.8	-0.9	-0.7	0.4	-0.6	0.2	-0.8	0.9	0.6	-0.4	-0.5	-1.2	-0.4
Pack years adult smoking proportion	0.4	0.6	2.4	-0.6	-0.3	-1.2	-0.9	-0.6	-0.2	-0.6	0.2	-1.6	-0.8	-0.7	-0.9	-0.4	-0.7	-0.6	-0.4	-0.8
Impedance of leg (right)	0.2	0.8	3.3	0.5	-0.7	-1.1	-1.4	0.5	0.7	0.2	0.7	-1.2	0.5	-1.4	-0.9	-1.8	-0.4	0.0	0.1	-0.7
Leg fat-free mass (left)	0.1	0.6	4.2	-0.0	0.1	0.7	1.5	-0.0	-0.4	0.3	0.3	-0.3	0.0	0.9	0.6	2.1	0.5	-0.0	0.1	1.0
Trunk fat percentage	0.4	1.6	6.4	1.0	2.5	1.5	1.4	1.0	1.2	1.1	-1.1	-0.0	0.9	0.2	0.3	2.3	0.7	0.6	0.9	1.2
Hand grip strength (right)	0.2	0.6	2.3	-0.5	-1.4	-1.5	-0.3	-0.5	-1.1	-0.6	-1.0	0.9	-0.6	0.0	-0.8	0.4	-0.4	0.3	-0.4	-0.4
Townsend deprivation index at recruitment	2.2	3.0	5.5	-2.0	1.6	0.7	-2.0	-2.0	-2.3	-2.2	1.0	-0.7	-1.9	-1.2	-0.0	-2.3	-2.3	-1.1	-1.6	-2.3
Current tobacco smoking	0.3	0.5	2.3	-0.8	-0.1	-0.6	-0.1	-0.8	-0.3	-0.5	1.5	-1.1	0.5	0.3	0.2	0.6	-0.3	0.7	-1.1	-0.1
Average weekly fortified wine intake	0.4	0.5	2.8	0.3	0.4	0.8	1.0	0.3	0.9	0.4	-1.1	-1.7	-0.3	0.6	0.4	0.4	0.6	-0.3	0.0	0.7
Maternal smoking around birth	1.5	2.1	5.3	1.3	1.6	2.2	1.4	1.4	2.3	1.4	-0.9	-0.7	1.3	0.9	1.5	1.6	1.6	-0.2	1.4	1.6
Fed-up feelings	0.1	0.2	0.6	-0.3	-0.8	-0.1	-0.8	-0.3	0.3	-0.4	0.1	0.8	0.3	-0.5	-0.3	0.1	-0.4	-0.2	-0.3	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.8	-0.7	1.1	0.6	-1.4	-0.7	0.4	-0.9	-1.3	0.5	-0.7	-1.4	-0.1	-1.7	-1.1	-1.3	-0.3	-1.4
Relative age voice broke	0.3	0.5	2.7	0.1	-0.2	-0.6	0.9	0.0	0.8	0.3	-1.6	0.2	0.5	0.9	0.4	0.9	0.6	0.8	-0.0	0.7
Taking other prescription medications	1.5	2.3	4.9	1.4	1.5	0.9	2.1	1.4	1.7	1.5	-1.3	-0.5	1.2	1.7	-0.1	2.2	1.5	1.8	1.5	1.8
Age when periods started (menarche)	0.1	0.3	1.8	0.0	0.1	0.0	-0.5	0.0	-0.6	-0.1	-0.5	0.7	-1.4	-0.5	0.0	-1.3	-0.3	-0.2	0.3	-0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.3	-0.6	-1.1	-1.1	-0.7	-0.6	0.0	-0.7	-1.5	-0.6	-0.9	-0.1	-1.3	-0.7	-0.4	-0.1	-0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.3	-0.1	-0.8	-0.1	0.3	-0.1	0.4	-0.2	0.7	-0.0	-0.6	0.9	-0.2	0.2	-0.1	0.2	0.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	4.1	-0.4	0.9	0.2	-0.5	-0.4	-1.2	-0.4	0.0	2.0	-1.2	-1.0	0.6	-0.9	-0.6	-0.6	-0.2	-0.6
Qualifications: CSEs or equivalent	0.3	0.4	1.2	0.6	0.7	0.6	0.2	0.6	-0.6	0.6	1.1	1.0	-0.2	-0.8	0.2	-0.1	0.3	-1.0	0.6	0.2
Serious illness, injury or assault to yourself	3.2	3.9	7.9	2.7	0.8	1.2	2.8	2.6	1.3	2.7	0.6	-1.4	0.7	2.0	-0.3	1.7	2.7	1.0	2.6	2.8
High blood pressure	0.5	1.3	4.4	1.3	-0.3	-1.2	1.2	1.4	0.2	1.3	0.2	-0.1	0.3	1.1	-2.1	1.2	1.0	1.2	1.6	1.1
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.3	0.1	-0.7	-0.3	0.6	0.1	0.5	0.3	-0.7	1.1	-0.5	0.7	0.8	-0.1	0.6	0.3	0.1	0.5
Multivitamins +/- minerals	1.1	1.4	6.7	-1.4	-0.3	0.8	-1.0	-1.4	0.2	-1.2	1.2	-0.6	0.5	-1.3	2.6	-0.2	-0.9	-1.0	-1.7	-1.0
Stomach or abdominal pain in last month	0.4	0.4	2.1	0.2	0.9	0.6	0.4	0.3	0.6	0.3	0.5	-0.7	1.1	0.2	0.7	1.5	0.2	0.8	0.3	0.4
Supplements: Glucosamine	0.9	1.1	4.4	0.6	-1.1	0.4	1.1	0.6	1.2	0.8	0.1	0.1	1.9	0.6	1.6	2.1	1.0	0.9	0.5	1.1
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	9.0	2.0	0.4	0.1	1.7	2.0	2.7	2.2	-0.2	0.0	3.0	0.4	0.9	2.9	1.5	1.7	2.0	2.0
Medication: Atenolol	1.3	1.6	7.2	-0.3	-0.6	-1.4	-0.2	-0.3	-1.8	-0.5	0.5	-2.0	-2.6	1.3	-2.7	-0.9	-0.2	-0.5	-0.3	-0.1
Medication: Levothyroxine sodium	0.4	0.6	3.0	-0.4	-1.2	-1.7	-0.9	-0.4	-1.2	-0.5	-0.1	0.0	0.4	-0.6	-1.3	0.7	-0.8	0.2	-0.5	-0.6
Sitting height	0.1	0.7	6.3	-0.5	0.3	0.7	-0.2	-0.5	-0.3	-0.5	1.2	-2.5	1.1	-0.3	0.4	1.0	-0.5	0.1	-0.5	-0.1
Chronic bronchitis/emphysema (father)	1.1	1.3	3.1	-0.7	1.2	1.4	-1.4	-0.7	-0.8	-1.0	-1.0	-1.5	-0.3	-1.8	-0.0	-1.8	-1.2	-1.0	-0.7	-1.4
High blood pressure (mother)	0.4	0.5	1.9	0.8	-0.7	-0.8	-0.4	0.8	-0.7	0.7	-1.3	-0.0	-0.0	-0.7	-1.4	-0.3	-0.0	-0.7	0.8	0.0
Body mass index (BMI)	0.2	1.0	4.8	0.4	1.9	1.7	1.7	0.4	0.2	0.5	-0.5	0.1	0.1	0.8	0.3	2.2	0.6	0.1	0.6	1.0
Impedance of leg (left)	0.3	1.3	4.6	0.3	-0.9	-1.7	-1.9	0.3	0.0	-0.0	0.9	-1.0	0.3	-2.0	-1.6	-2.1	-0.8	-0.2	-0.1	-1.1
Leg predicted mass (left)	0.1	0.6	4.2	-0.0	0.2	0.7	1.5	-0.0	-0.4	0.2	0.3	-0.3	0.0	1.0	0.7	2.0	0.5	0.0	0.0	1.0
Trunk fat mass	0.3	1.2	5.4	0.7	2.2	1.5	1.5	0.7	0.8	0.8	-0.9	-0.3	0.6	0.4	0.3	2.3	0.6	0.4	0.7	1.1
Waist circumference	0.5	1.9	6.0	1.2	2.0	1.6	2.1	1.2	1.2	1.3	-0.7	0.2	0.5	1.3	-0.2	2.5	1.3	0.5	1.3	1.7
Number of incorrect matches in round	0.5	0.8	3.4	-0.3	-0.9	-1.6	-0.5	-0.3	-1.0	-0.5	-1.3	0.6	-0.6	-0.4	-1.8	-1.1	-0.7	-0.3	-0.3	-0.8
Past tobacco smoking	1.4	2.6	7.2	1.7	-2.0	-2.7	1.4	1.7	1.7	1.8	-0.3	0.8	1.0	0.9	-2.2	1.9	1.4	1.5	1.2	1.6
Alcohol usually taken with meals	0.6	1.0	3.4	0.5	-0.3	-0.9	1.5	0.5	-1.0	0.6	-0.7	1.2	-1.5	1.9	-1.1	1.0	0.7	0.5	0.7	1.1
Nervous feelings	0.5	0.9	4.6	-0.3	-0.1	-0.5	-1.3	-0.3	0.5	-0.6	-1.6	0.4	-1.3	-1.0	-0.7	-2.1	-1.0	-0.6	-0.3	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	2.4	0.4	0.6	0.6	-0.3	0.4	0.1	0.1	-0.1	1.5	-0.5	-0.2	-0.5	-1.5	0.0	-0.3	0.6	-0.3
Hearing difficulty/problems with background noise	0.5	0.8	4.4	0.0	1.6	0.8	-0.7	0.0	-0.5	-0.1	-1.5	2.1	0.1	-1.2	0.3	-0.8	-0.7	-0.4	-0.1	-0.7
Hair/balding pattern: Pattern 2	0.2	0.3	1.0	-0.6	-1.0	-0.6	-0.4	-0.6	-0.2	-0.5	0.4	-0.9	-0.3	0.1	-0.4	-0.0	-0.2	-0.6	-0.6	-0.2
Had menopause	2.4	3.0	9.7	1.3	0.3	-0.0	2.0	1.3	1.5	1.4	-1.2	-1.1	1.8	2.6	-0.6	2.8	1.9	3.1	1.3	2.0
Had other major operations	0.6	0.8	4.3	0.5	1.3	2.1	0.8	0.5	0.9	0.5	-0.4	-0.7	-0.7	0.9	0.8	0.4	0.8	-0.1	0.9	0.8
Forced vital capacity (FVC)	0.4	1.7	4.4	-1.7	-0.6	-0.3	-2.1	-1.7	-1.3	-1.9	0.7	-0.3	-0.2	-1.2	0.6	-1.6	-1.5	-0.3	-1.4	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	0.9	0.7	0.3	0.2	0.9	0.8	0.9	-0.7	0.4	0.4	-0.5	0.7	-0.1	0.6	-0.1	0.7	0.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	4.5	0.7	1.6	1.8	0.5	0.7	1.5	0.8	-0.7	-1.7	0.5	-0.2	2.1	-0.7	0.6	-0.1	0.8	0.5
Qualifications: None of the above	0.4	0.9	7.1	0.3	2.7	2.2	-0.0	0.3	0.5	-0.0	-0.5	-0.1	0.8	-0.6	-0.1	0.5	-0.3	-0.1	0.6	-0.2
Financial difficulties in last 2 years	1.4	1.8	7.5	0.1	2.7	2.0	1.0	0.1	-0.1	0.2	2.7	-1.9	1.0	0.9	1.8	0.4	0.3	1.4	0.5	0.5
Mouth/teeth dental problems	0.2	0.3	0.8	0.7	0.0	0.4	0.4	0.7	0.8	0.8	0.0	-0.1	0.9	-0.4	0.4	0.2	0.5	-0.4	0.4	0.5
Heart attack	1.0	1.3	8.5	1.1	-0.4	-1.7	0.5	1.1	0.1	1.1	0.4	-1.8	-0.6	0.8	-2.9	0.4	0.8	0.4	0.6	1.0
Allergy	0.2	0.4	1.3	-0.3	-0.1	-0.9	-0.9	-0.3	-0.7	-0.5	0.7	-0.4	0.1	-0.7	-1.1	-0.7	-0.6	-0.3	-0.3	-0.8
Pain all over the body in last month	1.0	1.1	3.6	-0.7	0.6	0.0	-1.1	-0.7	-0.4	-0.8	-1.7	1.0	-0.6	-1.7	-0.6	-1.1	-1.1	-1.9	-0.8	-1.2
Diabetes (self-reported)	2.6	4.0	8.5	2.7	0.4	-0.2	2.3	2.7	1.4	2.5	0.3	1.3	1.8	1.3	-2.0	2.6	2.1	1.9	2.9	2.3
Hayfever/allergic rhinitis (self-reported)	3.8	5.0	11.9	2.1	-0.3	0.5	3.4	2.1	3.4	2.4	-1.2	0.3	1.1	2.6	1.2	3.0	2.9	2.0	2.3	3.0
Medication: Ramipril	2.4	3.0	6.3	2.5	-0.9	-0.8	1.8	2.5	0.7	2.3	0.3	2.3	1.1	1.2	-1.6	1.3	1.9	1.7	2.5	1.9
Medication: Simvastatin	2.1	3.0	5.4	2.1	1.3	0.9	2.2	2.2	1.5	2.1	0.1	-0.2	1.0	2.2	-1.2	2.2	2.1	1.4	2.2	2.3
Fluid intelligence score	0.4	0.8	3.4	0.7	-0.6	-0.6	0.9	0.7	1.8	0.8	-1.4	0.1	-0.2	1.3	0.2	0.2	1.1	0.9	0.4	1.1
Illnesses of siblings	0.6	0.8	4.1	0.6	0.1	0.2	0.5	0.6	0.8	0.6	1.8	0.6	2.0	0.3	-0.1	1.7	0.5	0.8	0.6	0.6
Neuroticism score	0.2	0.4	2.1	0.0	0.1	-0.2	-0.5	0.0	0.8	-0.2	-1.4	0.0	-0.7	-0.5	-1.1	-1.1	-0.4	-0.2	0.3	-0.6
Weight	0.2	1.1	6.7	0.6	1.1	1.1	1.9	0.6	0.0	0.7	0.0	-0.4	0.4	1.1	0.2	2.6	0.8	0.5	0.7	1.3
Impedance of arm (right)	0.2	0.8	3.8	1.0	-0.2	-0.4	-0.2	1.0	1.9	0.9	-1.5	-0.4	1.3	-0.0	0.1	-0.1	0.7	0.7	0.8	0.6
Arm fat percentage (right)	0.5	2.1	7.1	1.0	2.7	1.9	2.0	1.0	1.1	1.2	-1.3	0.3	0.8	1.1	0.4	2.7	1.1	0.6	1.2	1.6
Trunk fat-free mass	0.1	0.6	3.0	-0.0	-0.8	-0.5	1.2	-0.0	-0.7	0.2	0.8	-0.9	-0.2	1.1	-0.5	1.7	0.4	0.5	0.2	0.8
Hip circumference	0.7	2.9	11.2	1.2	1.6	1.6	2.9	1.2	1.2	1.4	0.2	-0.4	1.0	2.1	0.8	3.3	1.7	1.2	1.3	2.3
Time employed in main current job	0.4	0.5	2.4	0.1	-1.5	-0.8	-0.6	0.1	-0.6	0.0	-0.2	0.6	0.0	-1.0	-1.2	-0.6	-0.3	-0.6	0.1	-0.5
Alcohol intake versus 10 years previously	0.1	0.1	0.7	-0.1	-0.2	-0.8	0.1	-0.1	0.3	-0.1	-0.6	0.4	0.3	-0.1	-0.6	0.5	0.0	-0.0	-0.2	-0.0
Father’s age at death	0.5	0.7	3.4	-0.4	-0.5	-0.2	0.2	-0.4	0.8	-0.3	-1.8	0.0	1.4	0.3	1.0	1.3	-0.4	1.5	-0.5	0.0
Worrier / anxious feelings	0.3	0.5	1.7	0.1	-0.7	-0.3	-0.7	0.1	1.1	-0.1	-0.9	1.0	0.2	-0.8	-1.3	-1.3	-0.2	-0.7	0.1	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	2.7	0.2	0.1	-0.3	0.2	0.2	0.4	0.2	0.2	-1.1	0.2	0.8	-0.4	0.1	0.3	1.6	0.7	0.2
Falls in the last year	0.6	0.8	3.4	0.6	1.0	1.5	0.8	0.6	-0.3	0.6	1.9	0.7	0.3	1.1	0.8	0.5	0.7	0.5	0.6	0.8
Hair/balding pattern: Pattern 3	0.3	0.4	2.2	0.8	1.5	0.1	0.1	0.8	0.9	0.5	-0.7	0.6	0.2	-0.2	-0.9	-0.1	-0.1	0.2	0.8	0.2
Number of live births	0.6	0.9	2.6	0.7	0.1	-0.1	1.2	0.7	0.0	0.8	1.6	0.2	0.6	1.4	-0.2	1.2	0.9	1.5	0.9	1.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.0	-1.9	-1.1	-0.8	-2.2	-1.9	-1.3	-2.0	0.3	0.1	-0.1	-1.6	0.6	-1.6	-1.8	-0.3	-1.6	-2.1
Pulse rate	1.3	2.2	8.1	0.3	-1.8	-0.6	1.3	0.3	-1.6	0.6	1.9	2.8	-2.0	2.9	-0.0	0.0	1.6	0.7	0.5	1.4
Happiness	1.3	1.5	5.2	-0.9	1.3	1.3	-1.8	-0.9	-0.7	-1.1	0.9	-0.3	0.2	-1.9	0.4	-2.3	-1.3	-1.2	-0.6	-1.7
Noisy workplace	3.2	3.9	8.5	2.9	-0.6	-0.3	2.4	2.9	2.4	2.9	1.3	0.8	0.6	1.4	-0.7	1.1	2.8	1.2	2.5	2.6
Qualifications: A levels/AS levels or equivalent	0.9	2.1	7.6	-1.7	-2.8	-1.7	-0.8	-1.7	-2.7	-1.4	1.2	0.7	-1.4	0.7	0.6	-0.4	-0.6	-0.2	-1.9	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.0	0.0	0.7	0.9	0.2	0.0	0.2	0.1	0.4	-1.0	0.8	-0.3	0.9	0.3	-0.3	0.6	0.2	-0.0
Mouth/teeth dental problems: Dentures	0.4	0.6	2.2	-0.9	0.1	0.3	-0.2	-0.9	-0.4	-1.0	1.0	-1.5	-1.2	1.3	-0.2	-0.6	-0.4	0.5	-0.5	-0.4
Asthma	1.4	2.8	5.4	2.0	0.9	1.9	2.2	2.0	1.6	2.1	-0.2	0.3	1.3	1.5	0.5	2.0	2.0	0.9	2.0	2.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.7	-0.4	-0.9	0.2	0.1	-0.4	-0.2	-0.4	0.4	0.3	-1.3	0.5	-0.1	-0.5	0.1	-1.2	-0.4	-0.1
Medication: Cholesterol lowering	2.7	4.2	8.5	2.4	1.8	1.1	2.8	2.4	1.7	2.4	-0.7	-0.9	0.5	2.7	-1.2	2.5	2.5	1.0	2.5	2.9
Depression (self-reported)	0.6	0.7	2.6	-0.8	-0.1	-0.3	-1.1	-0.8	-0.6	-0.6	-0.2	-0.1	-0.1	-0.9	1.6	-1.4	-0.6	-0.5	-1.1	-0.9
Medication: Lansoprazole	0.8	0.9	2.0	-1.1	0.6	1.4	-1.1	-1.1	-0.1	-1.2	-1.4	0.2	0.7	-0.7	0.6	-0.6	-1.2	-0.1	-1.2	-1.1
Prospective memory result	0.4	0.5	2.5	0.5	0.6	0.3	0.8	0.5	-0.2	0.6	-0.4	-0.3	1.3	0.4	0.2	1.6	0.4	0.7	0.2	0.8
Lung cancer (father)	0.6	0.7	2.8	-0.3	0.5	0.2	-1.2	-0.3	-0.6	-0.7	1.0	0.3	-0.9	-0.5	-1.3	-1.7	-0.8	-0.7	-0.1	-1.0
Illnesses of mother	0.8	0.9	3.1	-1.2	1.0	1.2	0.1	-1.2	-0.3	-1.0	1.3	1.0	0.7	0.7	1.8	0.9	-0.3	1.0	-1.0	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	7.7	-2.3	-1.5	-1.1	-2.8	-2.3	-1.9	-2.4	1.0	0.7	-0.3	-2.2	0.2	-2.0	-2.3	-0.7	-2.2	-2.7
Pulse wave Arterial Stiffness index	0.2	0.2	1.3	0.1	-1.1	0.1	0.0	0.1	-0.5	0.1	0.7	-1.2	-0.5	0.3	0.3	-0.3	0.4	-0.2	0.1	0.2
Impedance of arm (left)	0.2	0.8	4.3	1.1	0.4	0.3	0.0	1.1	2.1	1.0	-1.2	-0.1	1.4	-0.1	0.7	0.1	0.9	0.4	0.7	0.7
Arm fat mass (right)	0.3	1.4	6.3	0.7	2.1	1.4	1.9	0.7	0.6	0.9	-0.8	-0.1	0.3	1.1	0.1	2.5	0.8	0.6	0.9	1.4
Trunk predicted mass	0.1	0.6	3.2	0.0	-0.7	-0.4	1.2	0.0	-0.6	0.2	0.8	-0.8	-0.1	1.1	-0.6	1.8	0.4	0.5	0.2	0.8
Standing height	0.1	0.6	2.7	0.4	-1.6	-1.2	0.5	0.4	-0.3	0.5	0.9	-1.2	0.5	0.6	-0.2	1.1	0.5	0.6	0.1	0.8
Length of working week for main job	2.1	2.4	4.9	-1.7	-0.9	-1.3	-1.7	-1.7	-2.2	-1.7	0.5	0.4	-2.0	-1.5	-0.5	-1.7	-1.5	-1.6	-1.5	-1.9
Exposure to tobacco smoke at home	1.1	1.2	6.6	0.8	1.8	2.6	1.3	0.8	0.1	0.8	1.9	0.2	0.0	0.9	1.0	-0.0	1.0	-0.2	1.0	0.8
Breastfed as a baby	2.2	2.8	7.0	-2.4	-0.1	-0.8	-1.7	-2.4	-2.6	-2.4	-0.5	1.6	-1.1	-0.4	-1.0	-0.6	-1.9	-1.0	-2.5	-1.8
Tense / ‘highly strung’	0.5	0.8	3.5	-0.4	-0.3	-0.5	-0.6	-0.4	0.1	-0.5	-1.0	1.7	-1.9	-0.4	-0.1	-1.8	-0.6	0.0	0.0	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.8	0.6	1.3	0.4	0.2	0.6	0.7	0.6	0.1	-0.9	0.7	-0.4	0.5	0.3	0.5	-0.1	0.2	0.4
Hair/balding pattern: Pattern 4	0.9	2.1	6.0	2.0	0.1	0.3	1.7	2.0	1.2	1.8	-0.7	0.9	0.5	1.6	-1.3	0.9	1.6	1.6	2.5	1.5
Birth weight of first child	0.8	1.4	6.9	0.2	-2.6	-1.5	0.7	0.2	-0.5	0.3	1.6	2.6	-1.0	1.3	-0.8	-0.3	1.0	0.4	0.0	0.7
Peak expiratory flow (PEF)	0.6	1.4	4.0	-1.3	-0.8	-0.3	-1.4	-1.3	-2.0	-1.4	1.4	0.1	-1.0	-0.8	0.6	-1.6	-1.3	0.2	-0.9	-1.6
Pulse wave reflection index	0.4	0.4	2.0	0.7	0.2	-0.5	-0.1	0.7	0.9	0.5	-0.1	-1.4	0.6	-1.1	-1.3	0.1	-0.0	-0.1	0.5	-0.1
Ever highly irritable/argumentative for 2 days	1.7	2.0	4.9	1.7	0.3	1.1	2.2	1.7	1.3	1.7	0.6	-0.6	-0.2	2.2	-0.2	0.3	2.1	0.8	1.8	2.0
Loud music exposure frequency	0.1	0.1	0.6	0.4	-0.1	-0.8	-0.2	0.4	-0.1	0.2	0.4	-0.1	0.1	-0.4	-0.6	-0.6	0.1	-0.3	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.9	-0.2	-1.1	-0.7	0.0	-0.2	0.5	0.1	-0.1	1.4	0.4	0.5	0.2	0.5	0.4	0.2	-0.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	1.2	-0.2	0.4	0.2	-0.5	-0.2	-0.4	-0.1	0.8	1.1	0.0	-0.4	0.6	-0.4	-0.2	-0.0	-0.1	-0.2
Blood clot in the leg (DVT)	0.6	0.8	2.8	-0.9	-0.4	-0.5	-1.1	-0.9	-1.7	-0.9	-1.3	-1.2	0.1	-0.5	-0.1	0.6	-1.0	0.2	-1.1	-0.7
Medication: Paracetamol	0.3	0.5	2.6	-0.1	-1.1	-1.1	-0.6	-0.1	-0.5	-0.2	-1.6	1.1	-0.6	-0.3	-0.9	0.0	-0.2	-0.6	-0.4	-0.2
Headache pain in last month	0.3	0.5	1.1	0.6	0.1	-1.0	0.4	0.6	-1.0	0.7	0.8	0.7	0.1	0.7	-1.1	0.7	0.6	0.8	0.8	0.6
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	3.9	-1.9	-1.9	-1.1	-1.9	-1.9	-1.0	-1.8	1.3	1.2	-0.5	-1.4	0.1	-1.5	-1.7	-0.6	-2.0	-1.9
Glaucoma (self-reported)	1.5	1.8	4.6	-2.1	-0.1	-0.5	-1.1	-2.1	-1.5	-2.0	-0.7	-1.8	-1.1	-0.3	0.8	-0.2	-1.6	0.0	-1.8	-1.4
Gout (self-reported)	0.4	0.5	2.6	0.4	-0.7	-1.4	-0.1	0.4	0.5	0.5	0.4	-0.3	1.6	-0.3	0.1	0.6	0.1	1.4	0.3	0.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.9	-0.9	-0.6	-0.9	-1.1	-0.9	-1.7	-0.9	-0.8	-0.1	0.1	-1.0	-0.7	0.2	-1.0	-0.7	-0.9	-0.9
Medication: Amlodipine	0.9	1.2	2.1	1.2	0.0	-0.4	1.4	1.2	1.2	1.2	-0.5	0.7	0.8	1.5	-0.9	1.3	1.1	1.2	1.4	1.3
Medication: Ventolin 100micrograms inhaler	2.0	2.5	5.3	1.9	0.0	0.6	2.0	1.9	0.9	1.9	-0.5	1.9	0.7	2.3	-0.6	1.8	2.2	0.9	1.6	2.3
Birth weight	1.9	4.0	8.2	2.8	-2.5	-1.2	2.2	2.8	1.9	2.6	0.5	2.4	0.3	1.3	-1.3	0.7	2.5	1.0	2.9	2.2
Chronic bronchitis/emphysema (mother)	1.8	2.1	10.6	1.5	3.3	2.7	0.8	1.5	1.6	1.4	0.9	0.9	0.5	0.3	-0.2	0.4	1.2	-1.2	1.6	1.2
High blood pressure (siblings)	0.9	1.4	8.4	-0.9	-0.4	-0.1	-0.3	-0.9	-1.0	-0.8	-2.1	-0.4	-2.9	0.0	0.1	-1.9	-0.5	-1.3	-0.9	-0.7
Forced vital capacity (FVC), Best measure	1.0	3.8	8.5	-2.3	-1.3	-1.0	-2.9	-2.3	-2.3	-2.5	1.5	0.5	-0.8	-2.1	-0.1	-2.5	-2.3	-0.9	-2.2	-2.7
Body fat percentage	0.4	1.4	7.2	0.8	2.7	1.7	1.3	0.8	1.0	0.8	-1.1	-0.2	0.8	0.2	0.4	2.1	0.6	0.3	0.7	1.0
Leg fat percentage (right)	0.3	1.1	5.1	0.6	2.2	2.0	1.4	0.6	0.8	0.6	-0.6	-0.3	0.5	0.6	0.6	1.8	0.7	0.2	0.5	1.0
Arm fat-free mass (right)	0.1	0.3	2.1	-0.5	-0.0	0.1	0.6	-0.5	-0.9	-0.3	0.8	-0.9	-0.2	0.1	-0.3	1.5	-0.3	-0.2	-0.4	0.1
Exposure to tobacco smoke outside home	0.8	1.1	2.4	-0.9	1.1	0.4	-1.3	-0.9	-0.4	-1.0	1.1	0.4	-0.2	-1.6	0.8	-1.5	-1.4	-0.7	-1.0	-1.4
Comparative body size at age 10	0.8	2.1	4.2	-1.8	-0.6	-0.6	-2.0	-1.8	-1.9	-1.9	0.1	-0.2	-0.4	-1.9	0.1	-1.2	-1.8	-1.1	-1.9	-2.0
Number of full brothers	1.0	1.3	6.5	1.0	2.6	1.3	0.7	1.0	0.8	0.8	0.5	-0.5	2.2	-0.5	-0.8	1.2	0.3	0.8	1.0	0.4
Worry too long after embarrassment	0.6	1.0	2.6	-0.4	-1.6	-0.8	-0.9	-0.4	-0.4	-0.5	-1.1	0.7	-1.6	-0.4	-1.4	-1.5	-0.3	-1.5	-0.4	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	1.3	0.1	-0.4	-0.6	-0.1	0.1	0.7	0.1	-1.1	0.2	-0.4	-0.4	0.5	-0.8	0.4	-0.4	-0.4	-0.0
Wheeze or whistling in the chest in last year	0.7	1.3	2.9	1.5	0.3	1.2	1.5	1.5	1.5	1.4	-0.8	0.1	-0.4	1.1	-0.1	0.6	1.4	-0.0	1.7	1.5
Number of children fathered	1.2	1.4	10.1	-0.2	3.2	2.5	-0.2	-0.2	-0.8	-0.1	-0.3	0.7	1.6	-0.8	1.2	1.0	-0.5	-0.2	-0.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.0	0.9	0.2	0.4	1.3	0.9	0.8	0.9	1.3	-0.4	0.5	1.4	-0.5	1.4	1.3	0.2	0.9	1.4
Age at first live birth	0.5	0.9	2.2	1.0	-0.9	-1.2	0.9	1.0	1.1	1.1	-0.3	1.5	0.9	0.2	0.3	1.2	0.9	0.8	0.9	1.0
Pulse wave peak to peak time	0.2	0.2	0.9	-0.2	0.9	-0.2	-0.1	-0.2	0.5	-0.2	-0.8	0.8	0.4	-0.3	-0.3	0.5	-0.5	0.2	-0.1	-0.2
Health satisfaction	0.2	0.2	0.9	-0.5	-0.3	0.4	-0.2	-0.5	-1.0	-0.4	-0.6	0.1	-0.8	0.0	0.7	-0.4	0.0	-0.7	-0.3	-0.3
Shortness of breath walking on level ground	1.3	1.6	4.2	1.9	0.5	0.7	1.5	1.9	0.9	1.8	1.1	0.0	0.1	1.1	-0.7	0.0	1.8	0.2	2.1	1.5
Qualifications: College or University degree	0.6	1.8	5.9	-1.5	-1.3	-2.2	-1.3	-1.5	-2.4	-1.3	1.5	-0.5	-0.8	-0.5	0.2	-0.6	-1.3	0.3	-1.8	-1.2
Eye problems/disorders: None of the above	0.2	0.3	0.8	-0.3	-0.3	-0.6	-0.9	-0.3	-0.5	-0.3	0.4	-0.7	-0.2	-0.5	-0.0	-0.8	-0.2	-0.3	-0.7	-0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.3	-0.0	0.7	1.2	0.9	-0.0	-0.2	0.0	0.8	0.5	-0.8	1.1	0.1	0.6	0.7	-0.7	0.1	0.7
Emphysema/chronic bronchitis	0.8	0.9	3.6	0.8	-1.1	-0.7	0.5	0.8	-0.6	0.7	0.1	1.9	-1.0	1.0	-1.5	-0.6	0.6	1.0	1.0	0.6
Medication for pain relief, constipation, heartburn	0.5	0.8	4.1	0.1	1.2	1.9	0.1	0.2	0.7	0.3	1.5	0.2	0.9	-0.7	2.0	-0.4	0.1	-0.5	0.2	0.2
Neck or shoulder pain in last month	0.3	0.4	2.7	-0.0	0.2	1.6	-0.3	-0.0	1.1	-0.1	-0.7	0.0	-0.7	-0.4	0.9	-0.8	-0.1	-0.9	0.2	-0.2
Medication: Blood pressure	1.6	2.8	5.8	2.2	0.9	0.3	2.3	2.2	0.9	2.2	-0.5	-1.3	0.2	2.0	-1.0	1.4	2.1	1.0	2.4	2.3
Angina (self-reported)	0.6	0.8	2.7	1.3	1.0	-0.0	0.5	1.3	-0.3	1.1	1.4	-1.2	0.4	0.0	-1.6	0.6	0.5	0.4	1.1	0.6
Migraine (self-reported)	0.7	0.8	2.2	-1.0	-0.9	0.1	-0.9	-1.0	-1.3	-0.9	-0.6	-1.3	-0.8	-0.5	0.5	-0.6	-0.8	-1.5	-1.1	-0.6
Medication: Ibuprofen	0.3	0.3	1.0	-0.8	-0.7	0.1	-0.4	-0.8	0.1	-0.8	0.0	0.4	-1.0	0.5	0.1	-0.8	-0.2	-0.8	-0.7	-0.4
Medication: Allopurinol	1.0	1.3	4.7	0.9	-0.0	-0.5	1.0	0.9	1.6	0.9	0.1	-0.3	2.1	0.8	0.2	1.8	0.8	2.2	1.0	0.9
Medication: Omeprazole	3.5	4.2	10.4	2.4	-0.4	-0.3	2.2	2.4	1.7	2.5	0.3	-1.6	2.7	2.0	-0.3	2.2	2.4	3.2	2.0	2.4
Medication: Seretide 50 evohaler	0.3	0.4	1.4	0.6	1.0	0.6	-0.1	0.6	0.2	0.5	0.6	1.2	0.9	-0.8	0.4	-0.3	-0.1	0.2	0.7	-0.0
Mean time to correctly identify matches	0.9	1.7	4.6	1.4	0.1	0.6	1.6	1.4	1.9	1.4	-1.4	0.1	0.1	2.1	-0.3	0.5	1.9	0.8	1.6	1.7
Heart disease (mother)	1.8	2.2	5.1	1.6	-0.5	-1.9	0.8	1.6	1.9	1.5	0.6	-1.8	1.7	0.3	-2.0	1.5	0.8	2.2	1.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.3	0.8	0.0	0.1	0.6	0.8	0.0	0.8	-0.3	-0.5	1.0	0.4	-0.4	0.8	0.7	1.1	0.4	0.7
Whole body fat mass	0.3	1.2	5.4	0.6	2.2	1.6	1.5	0.6	0.7	0.7	-0.8	-0.4	0.6	0.6	0.4	2.3	0.7	0.3	0.6	1.1
Leg fat mass (right)	0.3	1.1	4.5	0.6	2.1	1.8	1.5	0.6	0.6	0.6	-0.1	-0.5	0.4	0.6	0.4	2.0	0.6	0.2	0.6	1.0
Arm predicted mass (right)	0.1	0.5	2.2	-0.8	-0.5	-0.4	0.2	-0.8	-1.5	-0.6	0.7	-0.5	-0.5	-0.1	-0.5	1.1	-0.7	-0.3	-0.8	-0.2
Pulse rate, automated reading	1.8	5.8	28.5	1.6	-0.5	0.4	3.6	1.6	-0.2	1.9	1.5	2.7	-2.7	5.3	-0.1	1.3	3.7	1.4	1.9	3.4
Alcohol intake frequency.	0.1	0.2	2.3	-0.4	-0.2	-0.4	-0.0	-0.4	0.3	-0.3	-1.5	0.5	0.1	0.2	-0.1	0.7	-0.2	-0.1	-0.5	-0.1
Comparative height size at age 10	0.1	0.6	2.7	-0.2	-1.1	-0.1	0.3	-0.2	-0.9	-0.2	1.6	-1.6	0.3	0.8	0.0	1.2	0.2	0.3	-0.3	0.4
Number of full sisters	0.4	0.5	2.5	0.1	0.4	-0.6	0.0	0.1	-0.2	0.0	-1.5	1.1	0.3	-0.2	-1.6	1.1	-0.3	0.0	0.2	0.0
Suffer from ‘nerves’	2.2	3.4	10.6	-1.5	0.3	-0.4	-2.3	-1.5	-0.2	-1.8	-3.2	0.8	-1.6	-2.4	-0.7	-2.7	-2.2	-2.2	-1.7	-2.3
Overall health rating	0.1	0.3	1.7	0.4	1.3	0.6	0.4	0.4	0.2	0.4	-0.3	-0.6	-0.0	-0.4	-1.0	0.5	-0.2	-0.0	0.9	0.1
Chest pain or discomfort	0.4	0.6	4.0	-0.6	-0.1	-0.3	-0.3	-0.6	-0.6	-0.6	0.8	-0.6	-2.0	0.2	0.9	-1.4	0.3	-1.1	-0.4	-0.3
Had major operations	0.6	0.7	1.9	0.6	-0.3	-0.2	1.3	0.6	0.2	0.8	-0.8	-0.5	0.5	1.4	0.5	1.2	1.0	1.0	0.5	1.2
Age at last live birth	0.2	0.3	1.3	-0.1	-1.1	-1.1	0.2	-0.1	-0.2	0.1	0.5	0.5	0.1	0.4	0.4	0.8	0.2	0.5	-0.1	0.3
Family relationship satisfaction	0.3	0.4	1.6	0.7	-0.4	0.5	0.1	0.8	1.3	0.7	0.4	-0.2	1.0	-0.5	-0.6	-0.3	0.2	0.4	0.8	0.1
Leg pain on walking	1.0	1.3	3.7	1.1	-1.1	-0.3	1.3	1.1	-0.2	1.0	0.6	1.7	-0.4	1.9	-0.5	0.7	1.5	1.4	1.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	-0.2	0.1	-0.3	0.1	-0.2	0.4	-0.2	-1.0	-0.7	-0.7	-0.2	-0.4	0.0	-0.2	-0.9	-0.2	-0.0
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.2	-0.5	-0.6	0.1	-0.4	-0.5	-0.6	-0.5	-0.1	-0.2	0.7	-0.7	1.1	0.2	-0.4	0.6	-0.5	-0.6
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	9.4	-0.3	-3.1	-2.6	-0.9	-0.3	0.2	-0.3	-1.5	1.0	-0.4	0.4	-1.3	-0.3	-0.1	0.6	-0.7	-0.3
Medication: Aspirin	0.6	0.8	3.0	-0.0	-0.1	-1.0	1.0	-0.0	-0.6	-0.1	-1.5	-0.9	-1.0	1.5	-1.7	1.0	0.3	1.1	0.1	0.5
Supplements: Vitamin C	0.9	1.1	3.4	-1.4	-0.3	0.4	-1.0	-1.4	-0.3	-1.1	-1.1	-1.2	-0.7	-0.7	1.9	-0.0	-0.8	-1.4	-1.6	-0.7
Knee pain experienced in last month	0.4	0.6	3.2	0.3	0.1	0.2	0.7	0.3	1.8	0.3	-1.4	0.7	0.6	0.5	0.8	1.1	0.5	0.3	0.2	0.6
Hypertension (Self-reported)	0.8	2.1	4.4	1.7	-0.4	-1.3	1.8	1.7	0.6	1.7	-0.1	0.2	0.4	1.5	-2.0	1.8	1.5	1.4	2.1	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.6	2.8	-0.7	-0.5	0.8	-0.6	-0.7	0.4	-0.7	-1.7	-0.6	-0.3	-0.1	1.3	-1.3	-0.3	-0.7	-0.7	-0.6
Illnesses of father: Heart disease	0.6	0.9	3.5	-1.0	1.5	-0.0	-0.8	-1.0	-0.4	-1.0	0.7	-1.9	-0.8	-0.5	0.3	-0.9	-1.0	-0.2	-1.0	-1.0
Illnesses of siblings: Diabetes	0.3	0.4	1.2	-0.2	1.1	0.8	-0.7	-0.2	-0.5	-0.3	0.8	-1.0	-0.3	-0.8	0.0	-0.8	-0.5	-1.0	-0.2	-0.5
Smoking status: Previous	1.3	2.0	7.9	-1.1	2.1	2.8	-1.3	-1.2	-0.9	-1.4	-0.2	-1.4	-0.9	-0.7	1.5	-1.5	-1.0	-1.8	-0.7	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	3.6	-0.3	-0.9	-0.0	-0.8	-0.3	-0.1	-0.4	-1.0	-0.2	-0.8	-1.1	0.1	-0.9	-0.5	-1.9	-0.5	-0.6
Whole body fat-free mass	0.1	0.5	3.7	-0.2	-0.6	-0.2	1.2	-0.2	-0.9	0.1	0.7	-0.6	-0.1	0.9	-0.2	1.9	0.3	0.2	-0.1	0.7
Leg fat-free mass (right)	0.1	0.5	3.7	-0.1	-0.0	0.3	1.3	-0.1	-0.8	0.2	0.6	-0.1	-0.1	0.8	0.4	1.9	0.4	0.0	0.0	0.8
Arm fat percentage (left)	0.5	2.0	8.6	0.9	2.9	2.3	1.9	0.8	1.1	1.0	-1.4	0.2	0.5	0.8	0.8	2.5	1.0	0.2	0.9	1.4
Average weekly red wine intake	0.9	1.3	3.9	0.7	0.5	0.1	1.2	0.7	1.8	0.7	-1.6	1.2	0.3	1.6	-0.5	1.7	0.4	2.0	1.0	1.0
Handedness (chirality/laterality): Left-handed	1.3	1.5	7.1	0.7	-1.5	-2.5	0.0	0.7	-0.9	0.5	0.7	2.7	-0.7	0.1	-2.5	-0.5	0.5	0.1	0.6	0.1
Mood swings	0.2	0.3	3.6	-0.0	-0.3	0.3	0.0	-0.0	-0.3	-0.1	-0.2	-1.9	-0.5	0.4	-0.3	-0.6	0.3	0.0	-0.1	0.0
Loneliness, isolation	0.1	0.2	1.2	0.3	0.2	-0.0	-0.3	0.3	0.2	0.1	0.4	0.7	-0.5	-0.7	0.1	-1.1	-0.2	-0.4	0.4	-0.4
Long-standing illness, disability or infirmity	1.3	2.0	4.5	1.5	1.6	0.9	1.5	1.5	2.1	1.6	-0.3	-0.3	1.8	0.6	0.7	1.9	1.3	1.2	1.7	1.5
Ever had bowel cancer screening	1.2	1.4	6.1	-0.0	1.3	1.8	1.1	-0.0	-0.0	0.2	1.4	-2.5	0.1	1.5	1.6	1.2	0.7	1.0	-0.0	1.0
Diabetes diagnosed by doctor	2.9	4.7	10.8	2.8	1.0	-0.1	2.5	2.8	1.7	2.6	0.1	1.5	2.2	1.4	-2.1	3.3	2.0	2.1	3.0	2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	2.4	0.1	0.6	0.3	0.4	0.1	0.2	0.2	1.5	1.2	0.4	0.5	-0.5	0.3	0.3	0.5	0.4	0.3
Friendships satisfaction	0.3	0.4	1.2	0.6	0.6	0.3	-0.5	0.6	0.9	0.4	0.9	-1.1	0.9	-0.7	-0.8	-0.6	-0.1	0.4	0.5	-0.3
Qualifications: nursing, teaching	1.5	2.3	13.7	-0.8	-3.7	-3.1	-0.8	-0.8	-2.1	-0.8	0.6	0.7	-1.4	0.1	-1.7	-0.5	-0.7	0.3	-1.1	-0.7
Commuting to job workplace: Walk	0.7	0.8	4.8	0.3	1.8	1.4	0.7	0.3	0.9	0.2	0.5	-2.2	-0.0	0.9	0.0	0.3	0.3	0.5	0.5	0.6
Eye problems/disorders: Cataract	1.4	1.6	3.6	-1.8	-0.2	0.1	-1.6	-1.8	-1.4	-1.8	0.0	0.7	-0.2	-1.0	-0.1	-1.0	-1.9	-0.7	-1.7	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	2.8	0.4	1.1	0.1	0.4	0.4	0.3	0.2	-1.7	-0.7	-0.3	0.1	-1.1	0.5	-0.0	0.2	0.6	0.1
Medication for cholesterol	1.6	2.4	15.9	-1.3	1.4	2.2	-0.8	-1.3	0.4	-1.1	-0.8	-2.3	0.1	-1.1	4.0	-1.1	-0.7	-1.2	-1.5	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	8.1	-0.3	-0.1	-1.4	-0.3	-0.3	-1.2	-0.5	0.1	0.7	-0.9	0.6	-2.8	0.6	-0.4	0.3	-0.1	-0.3
Back pain experienced in last month	0.5	0.7	2.8	-0.9	1.1	0.5	-0.0	-0.9	-0.8	-0.9	0.5	1.7	-1.6	1.1	-0.0	-0.5	-0.2	0.5	-0.2	-0.3
Mineral and other dietary supplements	0.4	0.5	2.2	0.1	0.3	-0.6	-0.3	0.0	-0.2	0.0	0.6	0.7	-1.4	-0.4	-1.5	-1.2	-0.1	-1.1	0.3	-0.3
Breast cancer (self-reported)	0.5	0.6	4.8	-0.2	1.4	1.3	-0.1	-0.2	0.2	-0.0	-0.5	-0.4	0.5	-0.4	2.2	-0.1	-0.0	0.1	-0.2	-0.0
Asthma (self-reported)	1.1	2.2	4.1	1.8	1.0	1.8	1.9	1.8	1.3	1.8	-0.0	0.1	1.1	1.3	0.6	1.8	1.7	0.7	1.7	2.0
Osteoporosis (self-reported)	0.3	0.3	1.5	-0.3	1.0	0.8	-0.6	-0.3	1.2	-0.5	0.1	-0.7	0.6	-0.2	0.2	-0.6	-0.4	-0.2	-0.2	-0.5
Osteoarthritis (self-reported)	0.8	1.0	2.5	0.6	-0.2	-0.1	1.2	0.6	1.0	0.8	1.5	-0.7	0.7	1.4	1.1	0.7	1.2	1.6	0.9	1.1
Medication: Aspirin	0.6	0.8	2.9	0.1	-0.1	-0.8	1.2	0.1	-0.5	0.1	-1.5	-0.5	-1.0	1.7	-1.5	1.3	0.5	0.8	0.1	0.7
Medication: Gliclazide	1.3	1.5	4.4	1.1	2.0	0.9	1.4	1.1	0.8	1.0	1.0	-1.8	1.0	0.7	-0.1	2.1	0.8	0.9	1.1	1.2
Illnesses of father: None of the above (group 1)	1.3	1.6	5.8	-1.8	-0.3	0.6	-1.1	-1.7	-0.5	-1.6	0.3	2.4	-0.9	-0.2	0.9	-0.4	-0.8	-2.2	-1.6	-1.0
Smoking status: Current	0.3	0.4	2.5	-0.8	-0.3	-0.6	-0.1	-0.8	-0.5	-0.5	1.6	-0.4	0.4	0.3	0.4	0.5	-0.3	0.9	-1.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	-0.8	-0.8	0.2	-0.5	-0.8	0.4	-0.8	-0.2	0.4	1.0	0.0	0.9	0.5	-0.4	0.8	-0.9	-0.5
Whole body water mass	0.1	0.5	3.9	-0.1	-0.5	-0.1	1.3	-0.1	-0.8	0.1	0.7	-0.6	-0.1	0.9	-0.1	2.0	0.3	0.3	0.0	0.8
Leg predicted mass (right)	0.1	0.5	4.0	0.0	-0.0	0.3	1.4	0.0	-0.7	0.3	0.6	-0.0	-0.0	0.8	0.3	2.0	0.5	0.0	0.1	0.9
Arm fat mass (left)	0.4	1.6	7.3	0.8	2.2	1.6	2.0	0.8	0.7	0.9	-0.8	-0.1	0.3	1.1	0.2	2.7	1.0	0.5	1.0	1.5
Number of self-reported non-cancer illnesses	0.3	0.4	2.0	0.0	-0.0	0.1	0.9	0.0	0.4	0.1	0.1	-0.9	-0.1	1.3	0.2	1.1	0.6	1.4	0.4	0.6
Average weekly champagne plus white wine intake	0.5	0.7	3.1	-0.6	-1.1	-0.5	-0.2	-0.6	-1.7	-0.5	-0.1	-1.0	-1.8	-0.1	-0.4	-0.6	-0.1	-1.5	-0.5	-0.3
Miserableness	0.2	0.3	1.7	-0.3	0.3	0.3	-0.3	-0.3	-0.6	-0.4	-0.4	0.7	-0.9	-0.4	-0.1	-1.3	-0.5	0.0	-0.1	-0.6
Guilty feelings	0.4	0.7	2.0	-0.2	0.3	0.3	-1.3	-0.2	0.3	-0.4	-1.1	0.4	-0.1	-1.4	-0.9	-1.1	-0.9	-1.3	-0.1	-1.0
Wears glasses or contact lenses	0.5	0.6	2.5	-0.8	-0.2	-0.1	0.3	-0.8	-0.9	-0.6	-0.2	1.4	-0.7	1.6	0.6	0.5	0.2	1.0	-0.8	0.2
Ever taken oral contraceptive pill	0.4	0.5	1.4	0.7	0.1	0.8	0.7	0.7	0.3	0.6	0.5	-0.9	-0.6	1.1	0.3	0.1	1.2	-0.2	0.9	0.9
Hearing aid user	0.2	0.2	1.3	-0.1	0.6	0.7	0.5	-0.1	0.2	-0.2	-0.8	-0.7	-1.1	0.7	0.0	-0.4	0.1	0.1	0.2	0.1
Mother’s age at death	0.6	0.8	3.2	-0.0	-1.2	-1.4	-0.6	-0.0	0.7	-0.1	-1.5	-0.9	0.7	-0.4	-1.8	1.1	-0.7	0.5	-0.3	-0.2
Financial situation satisfaction	0.2	0.3	1.1	-0.6	-0.8	-0.8	-0.3	-0.6	0.2	-0.4	0.3	-1.0	0.3	-0.2	-0.2	0.8	-0.6	0.2	-0.3	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	2.3	-0.1	0.4	-0.5	-0.5	-0.1	-0.9	-0.2	1.5	0.4	-0.0	-0.4	-0.6	0.1	-0.3	-0.5	-0.0	-0.3
Commuting to job workplace: Public transport	0.8	0.9	5.7	0.2	-0.4	-1.0	0.5	0.2	-0.1	0.4	-1.5	0.4	-2.4	1.3	-0.9	-1.0	0.9	-1.0	0.4	0.7
Eye problems/disorders: Glaucoma	1.3	1.6	5.4	-1.8	0.7	0.2	-1.0	-1.8	-0.5	-1.7	-0.9	-2.3	-0.5	-0.7	1.3	-0.4	-1.5	-0.3	-1.6	-1.3
Medication: Blood pressure	1.0	2.0	13.6	0.9	-1.5	-2.5	0.1	0.9	-1.0	0.7	0.6	2.4	-0.3	0.3	-3.7	0.5	0.1	0.7	1.0	0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	3.3	-0.1	0.8	-0.0	-0.2	-0.1	0.7	-0.1	1.8	-0.9	-0.2	-0.3	0.2	-0.2	-0.2	0.3	0.1	-0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.1	0.4	-0.2	0.6	0.8	0.4	0.5	0.5	-0.7	-1.4	1.2	1.0	1.5	0.9	0.8	1.4	0.3	0.9
High cholesterol (Self-reported)	0.9	1.7	4.5	1.5	-0.3	-0.4	1.6	1.5	-0.0	1.3	0.3	-0.2	-0.6	2.0	-2.1	1.6	1.5	0.7	1.5	1.6
Medication: Bendroflumethiazide	0.3	0.4	2.7	-0.7	0.4	0.2	-0.6	-0.6	-0.3	-0.7	0.2	-1.6	0.1	-0.4	0.1	-0.5	-0.7	0.6	-0.5	-0.7
Medication: Paracetamol	0.3	0.4	2.7	0.2	-0.5	-0.4	0.4	0.2	-0.3	0.2	-1.6	0.8	-0.5	1.1	-0.6	0.8	0.6	0.3	0.1	0.6
Medication: Lisinopril	0.6	0.7	2.9	-0.8	-0.4	-1.1	-0.3	-0.8	-1.2	-0.7	-0.1	-1.4	-1.7	-0.9	-0.2	-0.6	-0.7	-0.5	-0.2	-0.9
Medication: Atorvastatin	2.5	3.1	6.7	1.9	-0.4	-0.9	2.6	1.9	0.4	1.9	0.8	-0.5	-0.0	2.6	-2.3	2.3	2.0	1.3	1.8	2.4
Illnesses of father: High blood pressure	2.4	2.9	7.2	2.7	-0.1	-0.7	1.5	2.7	1.2	2.5	0.2	0.3	1.2	0.8	-2.0	0.8	1.7	2.2	2.7	1.8
Alcohol drinker status: Never	1.1	1.3	3.3	-1.6	-0.7	-0.5	-1.7	-1.6	-1.5	-1.5	-0.1	0.5	-0.2	-0.9	-0.3	-0.5	-1.8	-0.0	-1.6	-1.5
Ever smoked	1.7	3.0	4.7	-2.0	2.0	2.0	-2.0	-2.0	-1.1	-2.0	1.1	-1.0	-0.6	-1.5	1.9	-2.2	-2.1	-0.8	-1.6	-2.2
Basal metabolic rate	0.1	0.6	4.2	0.1	-0.1	0.1	1.4	0.1	-0.7	0.3	0.6	-0.5	-0.0	0.9	-0.0	2.1	0.4	0.3	0.2	0.9
Leg fat percentage (left)	0.2	0.8	4.9	0.6	2.2	1.6	1.1	0.6	0.4	0.5	-0.6	-0.1	0.4	0.2	0.1	1.6	0.4	0.1	0.5	0.7
Arm fat-free mass (left)	0.1	0.4	3.3	-0.2	-0.3	-0.4	0.9	-0.2	-0.8	-0.0	0.7	-0.6	0.1	0.6	-0.6	1.8	-0.0	0.6	-0.0	0.4
Number of operations (self-reported)	1.2	1.7	3.9	1.1	0.4	1.2	1.9	1.1	1.1	1.2	0.5	-2.0	0.4	1.9	0.7	1.5	1.8	1.0	1.1	1.8
Average weekly beer plus cider intake	0.6	0.9	2.8	-0.8	-0.6	-0.1	-1.0	-0.8	0.2	-0.8	-0.2	1.3	-0.8	-1.6	0.2	-1.1	-1.1	-1.7	-0.5	-1.1
Irritability	0.5	0.9	1.7	1.1	-1.3	-1.1	0.9	1.1	0.3	1.1	0.7	-0.1	-0.9	0.6	-1.3	-0.4	1.1	0.3	1.3	0.8
Risk taking	0.8	1.2	5.8	-0.6	1.6	0.8	-0.5	-0.6	0.1	-0.6	0.5	-2.4	1.9	-1.4	0.9	1.1	-1.0	0.2	-0.6	-0.7
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.9	0.8	1.1	1.4	1.3	0.8	2.0	0.9	-2.0	-0.4	-0.8	1.2	0.5	0.2	1.3	-0.8	0.6	1.2
Fractured/broken bones in last 5 years	0.8	1.0	2.9	0.4	0.5	0.8	1.1	0.3	0.8	0.6	0.1	-1.7	1.3	1.1	1.3	1.6	0.8	1.4	0.5	1.0
Age started oral contraceptive pill	2.1	2.6	5.9	1.4	-1.5	-1.5	1.3	1.4	2.2	1.6	-2.3	0.1	1.9	1.4	-0.3	2.4	1.4	2.0	1.1	1.7
Diastolic blood pressure, automated reading	0.5	1.6	7.0	-0.2	-1.9	-1.4	1.2	-0.2	-1.3	-0.2	-0.7	-0.5	-2.3	2.6	-1.4	0.4	0.9	1.1	0.2	0.8
Ever depressed for a whole week	2.8	3.5	7.7	2.5	-0.1	0.8	2.2	2.5	1.8	2.8	-0.8	0.1	1.7	1.3	1.2	1.4	2.6	1.5	2.6	2.5
Unable to work because of sickness or disability	0.8	1.1	2.7	1.2	1.5	1.6	1.2	1.2	1.5	1.2	-0.6	0.1	0.6	-0.2	1.5	0.1	0.9	-0.1	1.2	0.8
Commuting to job workplace: Cycle	1.5	1.8	5.0	-1.3	2.2	0.7	-1.7	-1.3	-1.5	-1.4	-0.2	1.2	0.6	-1.9	0.6	-0.4	-1.8	-0.9	-1.1	-1.7
Myopia	0.4	0.6	2.5	-0.0	1.1	1.5	-0.4	-0.0	0.0	-0.0	-0.5	-0.9	0.8	-1.0	1.6	-0.8	-0.3	0.1	-0.2	-0.4
Vascular/heart problems diagnosed by doctor	0.5	1.2	5.1	-1.4	-0.0	1.0	-1.3	-1.4	0.0	-1.3	-0.1	0.5	0.1	-1.1	2.2	-0.9	-1.1	-1.0	-1.5	-1.1
Cholesterol lowering medication	1.4	2.1	5.5	1.4	-1.4	-1.6	1.5	1.4	0.2	1.3	0.9	1.3	0.2	1.8	-2.3	1.5	1.3	2.2	1.5	1.3
Medication: Omeprazole (e.g. Zanprol)	4.0	4.8	10.2	2.7	-0.9	-0.7	2.5	2.7	1.8	2.8	-0.2	-0.3	2.6	2.4	-0.6	2.4	2.7	3.2	2.3	2.8
Pain experienced in last month	0.2	0.4	0.9	0.9	-0.6	-0.4	0.6	0.9	0.6	1.0	0.3	-0.8	0.7	0.1	0.1	0.1	0.6	0.7	0.7	0.7
Supplements: Calcium	4.2	4.7	10.8	-3.1	-0.9	-0.6	-1.9	-3.1	-2.5	-3.0	-1.6	-1.9	-2.5	-0.6	1.2	-2.0	-2.1	-1.4	-3.3	-2.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	-0.5	-1.2	-1.0	-0.9	-0.5	-0.6	-0.6	0.0	-0.3	-0.9	-0.5	-1.0	-1.0	-0.4	-1.1	-0.5	-0.7
Heart attack/myocardial infarction (self-reported)	1.2	1.5	8.4	1.4	-0.1	-1.5	0.7	1.4	0.5	1.4	0.1	-2.0	-0.3	0.9	-2.9	0.7	0.9	0.6	1.0	1.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.3	-1.2	-0.4	-0.5	-1.3	-1.2	-1.6	-1.2	-1.8	-1.2	-0.2	-0.6	-0.2	0.5	-1.2	-0.1	-1.3	-0.9
Heart disease (siblings)	0.5	0.6	1.7	0.9	0.5	-0.7	0.7	0.9	0.5	0.8	0.1	0.4	0.6	0.9	-1.2	0.5	0.8	1.3	0.9	0.7
Alcohol drinker status: Previous	0.3	0.3	2.1	0.0	1.1	0.7	-0.4	0.0	1.0	-0.1	-1.4	0.0	-0.2	0.0	0.2	-0.4	-0.1	-0.2	0.3	-0.2
Pack years of smoking	0.2	0.3	2.0	-0.1	-0.3	-1.0	-0.5	-0.1	0.2	-0.1	-0.1	-1.4	-0.7	-0.1	-1.2	-0.1	-0.3	-0.1	0.2	-0.3
Impedance of whole body	0.1	0.6	2.2	0.6	0.1	-0.3	-1.2	0.6	1.4	0.4	-0.4	-0.7	1.1	-1.5	0.2	-1.2	-0.1	-0.2	0.2	-0.3
Leg fat mass (left)	0.2	0.9	4.2	0.6	1.9	1.4	1.5	0.6	0.4	0.6	-0.2	-0.5	0.3	0.5	0.1	2.0	0.6	0.2	0.6	1.0
Arm predicted mass (left)	0.1	0.4	3.3	-0.2	-0.2	-0.3	0.8	-0.2	-0.9	-0.0	0.8	-0.8	0.3	0.3	-0.5	1.8	-0.1	0.4	-0.1	0.4