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chr3:48,757,291-50,833,360

Best TWAS P=4.5e-12 · Best GWAS P=2.22e-10 conditioned to 0.36

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
95	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RBM6	0.16	0.12	blup	79	0.09	4.4e-04	-6.3	-6.9	4.5e-12	0.94	0.03	0.96	TRUE
46	GTEx	Nerve Tibial	MST1	0.27	0.03	lasso	8	0.10	1.9e-07	-4.7	-5.4	6.2e-08	0.26	0.95	0.01	TRUE
31	GTEx	Colon Transverse	RBM6	0.29	0.33	enet	43	0.36	4.6e-18	-6.3	-6.9	5.3e-12	0.97	0.03	0.97	FALSE
29	GTEx	Cells Transformed fibroblasts	MST1R	0.05	0.04	lasso	3	0.04	3.8e-04	-6.3	6.7	1.7e-11	-0.91	0.04	0.95	FALSE
64	GTEx	Vagina	RBM6	0.24	0.22	enet	27	0.21	1.5e-05	-6.2	-6.7	2.4e-11	0.97	0.04	0.95	FALSE
33	GTEx	Esophagus Mucosa	RBM6	0.18	0.21	enet	18	0.23	3.0e-15	5.8	-6.6	3.9e-11	0.95	0.04	0.96	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RBM6	0.09	0.11	blup	79	0.11	3.8e-12	-6.3	-6.6	5.6e-11	0.99	0.03	0.97	FALSE
17	GTEx	Brain Cerebellar Hemisphere	FAM212A	0.25	0.17	lasso	21	0.20	8.1e-06	-6.3	6.5	6.5e-11	-0.88	0.05	0.89	FALSE
27	GTEx	Cells EBV-transformed lymphocytes	RBM6	0.27	0.21	enet	14	0.23	5.0e-08	-6.3	-6.5	6.8e-11	0.99	0.03	0.97	FALSE
60	GTEx	Testis	RBM6	0.28	0.14	enet	19	0.17	7.7e-08	6.0	-6.5	8.3e-11	0.91	0.07	0.93	FALSE
75	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RBM6	0.06	0.09	enet	27	0.10	9.3e-09	-6.3	-6.5	9.1e-11	0.99	0.03	0.97	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	RBM6	0.03	0.04	blup	79	0.05	9.5e-10	-6.3	-6.5	9.3e-11	0.96	0.03	0.97	FALSE
88	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RBM6	0.09	0.07	blup	79	0.08	1.3e-04	-6.3	-6.5	1.1e-10	0.96	0.05	0.94	FALSE
85	The Cancer Genome Atlas	Brain Lower Grade Glioma	RBM6	0.10	0.14	enet	17	0.14	7.7e-16	-6.3	-6.4	1.5e-10	1.00	0.03	0.97	FALSE
59	GTEx	Stomach	RBM6	0.16	0.22	lasso	11	0.19	2.1e-09	-6.3	-6.4	1.6e-10	1.00	0.03	0.97	FALSE
45	GTEx	Nerve Tibial	RBM6	0.41	0.42	enet	19	0.41	8.8e-31	-6.3	-6.4	1.8e-10	0.99	0.03	0.97	FALSE
28	GTEx	Cells Transformed fibroblasts	RBM6	0.27	0.29	enet	17	0.31	1.3e-23	-6.3	-6.4	2.1e-10	0.97	0.03	0.97	FALSE
65	GTEx	Whole Blood	RBM6	0.14	0.19	lasso	3	0.18	2.4e-16	-6.3	-6.4	2.1e-10	1.00	0.03	0.97	FALSE
47	GTEx	Pancreas	RBM6	0.23	0.20	lasso	4	0.22	1.3e-09	-6.3	-6.3	2.2e-10	0.99	0.03	0.97	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	MST1R	0.05	0.07	enet	7	0.05	7.1e-04	-6.3	6.3	2.4e-10	-1.00	0.04	0.95	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	FAM212A	0.05	0.04	enet	21	0.01	1.1e-01	-6.3	6.3	2.4e-10	-1.00	0.04	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RBM6	0.16	0.19	lasso	9	0.19	1.2e-22	-6.3	-6.3	2.5e-10	0.99	0.03	0.97	FALSE
25	GTEx	Breast Mammary Tissue	RBM6	0.25	0.35	enet	26	0.38	7.4e-21	-6.3	-6.3	2.5e-10	0.99	0.03	0.97	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RBM6	0.05	0.06	lasso	10	0.04	9.1e-06	-6.3	-6.3	2.5e-10	1.00	0.03	0.97	FALSE
69	METSIM	Adipose	RBM6	0.22	0.34	lasso	15	0.34	1.7e-52	-6.3	-6.3	2.7e-10	0.99	0.03	0.97	FALSE
72	ROSMAP	Brain Pre-frontal Cortex	RBM6	0.21	0.32	enet	31	0.34	1.5e-44	-6.3	-6.3	2.7e-10	0.97	0.03	0.97	FALSE
54	GTEx	Skin Sun Exposed Lower leg	RBM6	0.23	0.27	lasso	8	0.29	7.6e-24	-6.3	-6.3	2.9e-10	0.99	0.03	0.97	FALSE
6	GTEx	Adrenal Gland	RBM6	0.12	0.05	enet	18	0.05	5.9e-03	-6.3	-6.3	3.0e-10	1.00	0.03	0.95	FALSE
24	GTEx	Brain Putamen basal ganglia	RBM6	0.15	0.22	lasso	4	0.12	7.4e-04	-6.3	-6.3	3.1e-10	1.00	0.04	0.93	FALSE
80	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RBM6	0.04	0.05	blup	79	0.05	2.0e-06	5.8	-6.3	3.1e-10	0.97	0.06	0.94	FALSE
11	GTEx	Artery Tibial	RBM6	0.24	0.31	enet	24	0.30	5.8e-24	-6.3	-6.3	3.4e-10	0.98	0.03	0.97	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	RBM6	0.08	0.06	blup	79	0.07	4.3e-08	5.8	-6.3	3.5e-10	0.95	0.03	0.97	FALSE
26	GTEx	Breast Mammary Tissue (Female)	RBM6	0.23	0.27	enet	16	0.26	2.7e-08	5.8	-6.3	3.7e-10	0.99	0.04	0.96	FALSE
38	GTEx	Heart Atrial Appendage	RBM6	0.34	0.36	lasso	6	0.35	1.2e-16	-6.3	-6.3	3.9e-10	0.99	0.04	0.96	FALSE
44	GTEx	Muscle Skeletal	RBM6	0.11	0.15	enet	13	0.15	3.1e-14	-6.3	-6.3	3.9e-10	0.98	0.04	0.96	FALSE
70	NTR	Blood	RBM6	0.06	0.14	enet	36	0.13	7.9e-40	-6.3	-6.3	4.0e-10	0.99	0.03	0.97	FALSE
43	GTEx	Lung	MST1R	0.06	0.04	lasso	3	0.04	7.5e-04	-6.3	6.2	4.3e-10	-0.98	0.04	0.92	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RNF123	0.14	0.10	blup	324	0.12	4.7e-14	5.1	6.2	4.5e-10	-0.73	0.93	0.07	FALSE
57	GTEx	Spleen	RBM6	0.36	0.39	lasso	8	0.40	2.0e-11	-6.3	-6.2	4.6e-10	0.97	0.04	0.96	FALSE
77	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RBM6	0.09	0.13	blup	79	0.12	1.6e-06	-6.3	-6.2	4.7e-10	0.99	0.03	0.97	FALSE
19	GTEx	Brain Cerebellum	MST1R	0.19	0.24	enet	22	0.20	1.8e-06	-6.3	6.2	5.4e-10	-0.94	0.06	0.94	FALSE
30	GTEx	Colon Sigmoid	RBM6	0.25	0.19	enet	7	0.13	2.3e-05	-6.3	-6.2	5.5e-10	0.99	0.04	0.96	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	RBM6	0.09	0.15	enet	16	0.15	1.1e-15	-6.3	-6.2	5.6e-10	0.99	0.03	0.97	FALSE
37	GTEx	Esophagus Muscularis	RBM6	0.22	0.29	lasso	7	0.30	1.1e-18	-6.3	-6.2	5.7e-10	0.99	0.03	0.97	FALSE
20	GTEx	Brain Cortex	RBM6	0.21	0.25	lasso	4	0.29	8.8e-09	-6.3	-6.2	6.4e-10	0.92	0.04	0.96	FALSE
18	GTEx	Brain Cerebellum	RBM6	0.25	0.41	enet	32	0.33	2.1e-10	-6.3	-6.2	6.7e-10	0.98	0.04	0.96	FALSE
62	GTEx	Thyroid	RBM6	0.25	0.35	lasso	15	0.36	1.9e-28	-6.3	-6.2	7.3e-10	0.98	0.03	0.97	FALSE
39	GTEx	Heart Left Ventricle	RBM6	0.09	0.08	enet	10	0.11	3.0e-06	-6.2	-6.1	8.1e-10	0.98	0.06	0.94	FALSE
40	GTEx	Liver	RBM6	0.21	0.11	enet	6	0.09	1.4e-03	5.8	-6.1	8.1e-10	0.98	0.04	0.91	FALSE
5	GTEx	Adipose Visceral Omentum	RBM6	0.20	0.28	enet	30	0.30	6.4e-16	-6.3	-6.1	8.6e-10	0.98	0.03	0.97	FALSE
7	GTEx	Artery Aorta	RBM6	0.32	0.36	lasso	6	0.41	3.3e-24	-6.3	-6.1	8.7e-10	0.99	0.03	0.97	FALSE
41	GTEx	Lung	RBM6	0.17	0.20	lasso	6	0.24	4.6e-18	-6.2	-6.1	9.4e-10	0.98	0.04	0.96	FALSE
74	YFS	Blood	RBM6	0.28	0.43	enet	57	0.44	4.0e-160	-6.3	-6.1	1.0e-09	0.98	0.03	0.97	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	RBM6	0.14	0.19	blup	79	0.20	1.4e-19	-6.3	-6.1	1.1e-09	0.98	0.03	0.97	FALSE
23	GTEx	Brain Nucleus accumbens basal ganglia	RBM6	0.20	0.19	enet	29	0.22	2.0e-06	-6.3	-6.1	1.3e-09	0.90	0.07	0.92	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	RBM6	0.25	0.29	lasso	23	0.30	2.2e-11	-6.2	-6.1	1.4e-09	0.95	0.04	0.96	FALSE
9	GTEx	Artery Aorta	UBA7	0.06	0.02	enet	12	0.01	5.3e-02	5.8	-6.0	1.5e-09	0.91	0.06	0.84	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	RBM6	0.16	0.17	enet	24	0.23	1.2e-12	-6.2	-6.0	1.6e-09	0.97	0.04	0.96	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RBM6	0.19	0.28	lasso	5	0.32	7.4e-09	6.0	-6.0	2.0e-09	0.95	0.04	0.96	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	MST1R	0.08	0.07	enet	10	0.09	2.6e-10	5.7	6.0	2.3e-09	-0.82	0.02	0.98	FALSE
4	GTEx	Adipose Subcutaneous	RBM6	0.25	0.35	lasso	9	0.35	1.8e-29	-6.3	-6.0	2.4e-09	0.97	0.03	0.97	FALSE
42	GTEx	Lung	TCTA	0.09	0.01	enet	10	0.03	3.3e-03	4.1	6.0	2.6e-09	-0.27	0.06	0.15	FALSE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRAIP	0.02	0.01	enet	8	0.01	3.1e-02	4.8	5.9	4.0e-09	-0.75	0.03	0.38	FALSE
8	GTEx	Artery Aorta	APEH	0.05	0.03	enet	8	0.01	9.1e-02	-6.3	-5.9	4.3e-09	0.95	0.06	0.86	FALSE
22	GTEx	Brain Frontal Cortex BA9	RBM6	0.18	0.25	lasso	3	0.20	5.2e-06	5.7	5.8	5.6e-09	-0.94	0.04	0.95	FALSE
55	GTEx	Skin Sun Exposed Lower leg	MST1R	0.06	0.07	lasso	2	0.06	1.1e-05	5.8	5.8	5.6e-09	-0.94	0.04	0.95	FALSE
12	GTEx	Artery Tibial	MST1R	0.06	0.02	lasso	5	0.02	1.5e-02	5.8	5.8	7.3e-09	-0.83	0.05	0.75	FALSE
50	GTEx	Prostate	RBM6	0.14	0.12	enet	15	0.05	1.8e-02	-6.3	-5.8	7.3e-09	0.97	0.04	0.88	FALSE
48	GTEx	Pituitary	RBM6	0.27	0.21	enet	22	0.19	1.5e-05	-6.3	-5.7	9.3e-09	0.91	0.05	0.94	FALSE
91	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBA7	0.02	0.01	blup	30	0.02	5.3e-03	4.8	-5.7	9.3e-09	0.82	0.03	0.71	FALSE
63	GTEx	Thyroid	MST1R	0.06	0.06	enet	9	0.05	1.7e-04	5.8	5.7	1.1e-08	-0.91	0.06	0.93	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	MST1R	0.03	0.01	blup	32	0.03	3.1e-04	5.7	5.7	1.1e-08	-0.95	0.02	0.94	FALSE
83	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RBM6	0.14	0.17	lasso	5	0.17	5.7e-10	5.8	-5.7	1.4e-08	0.97	0.03	0.97	FALSE
13	GTEx	Artery Tibial	UBA7	0.04	0.03	lasso	4	0.02	7.8e-03	-5.4	-5.7	1.5e-08	0.83	0.14	0.33	FALSE
79	The Cancer Genome Atlas	Esophageal Carcinoma	RBM6	0.25	0.09	lasso	11	0.05	8.9e-03	5.2	-5.6	2.3e-08	0.62	0.06	0.60	FALSE
10	GTEx	Artery Coronary	RBM6	0.14	0.14	enet	23	0.15	1.0e-05	5.1	-5.6	2.6e-08	0.87	0.16	0.84	FALSE
67	METSIM	Adipose	MST1	0.06	0.03	lasso	8	0.03	2.0e-05	-4.7	-5.6	2.6e-08	0.37	0.73	0.15	FALSE
35	GTEx	Esophagus Mucosa	RNF123	0.07	0.03	enet	9	0.04	1.8e-03	4.9	5.5	3.4e-08	-0.75	0.56	0.10	FALSE
92	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CAMKV	0.07	0.05	enet	9	0.06	2.3e-03	4.9	5.5	4.4e-08	-0.72	0.02	0.45	FALSE
94	The Cancer Genome Atlas	Stomach Adenocarcinoma	RBM6	0.05	0.05	blup	79	0.06	3.7e-05	-6.3	-5.4	5.1e-08	0.97	0.04	0.94	FALSE
81	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MST1R	0.03	0.04	blup	32	0.05	4.0e-06	5.8	5.4	5.2e-08	-0.94	0.02	0.98	FALSE
61	GTEx	Testis	MON1A	0.08	0.06	enet	13	0.05	2.4e-03	5.0	-5.4	6.8e-08	0.90	0.11	0.76	FALSE
68	METSIM	Adipose	MST1R	0.03	0.02	blup	331	0.02	1.7e-03	5.7	5.4	7.0e-08	-0.86	0.40	0.54	FALSE
71	NTR	Blood	UBA7	0.02	0.03	lasso	4	0.03	1.6e-09	4.9	-5.4	8.7e-08	0.84	0.26	0.74	FALSE
34	GTEx	Esophagus Mucosa	APEH	0.16	0.08	lasso	4	0.12	1.2e-08	-5.0	-5.3	8.9e-08	0.32	0.97	0.01	FALSE
49	GTEx	Pituitary	RNF123	0.13	0.04	lasso	4	0.01	2.0e-01	-6.2	5.3	9.1e-08	-0.82	0.06	0.51	FALSE
21	GTEx	Brain Cortex	RNF123	0.23	0.05	enet	33	0.04	2.4e-02	5.0	5.3	1.0e-07	-0.78	0.23	0.14	FALSE
58	GTEx	Spleen	UBA7	0.19	0.14	lasso	22	0.11	8.8e-04	4.8	-5.3	1.0e-07	0.78	0.42	0.16	FALSE
66	GTEx	Whole Blood	UBA7	0.03	0.04	lasso	2	0.01	1.5e-02	4.9	-5.3	1.3e-07	0.81	0.26	0.47	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEMA3F	0.02	0.04	lasso	3	0.03	2.3e-04	-5.4	-5.3	1.3e-07	0.77	0.04	0.73	FALSE
36	GTEx	Esophagus Mucosa	UBA7	0.04	0.07	enet	8	0.05	4.5e-04	4.9	-5.3	1.4e-07	0.83	0.18	0.78	FALSE
56	GTEx	Small Intestine Terminal Ileum	MST1R	0.20	0.05	lasso	5	0.10	3.6e-03	5.0	5.3	1.4e-07	-0.92	0.07	0.71	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MST1R	0.03	0.05	lasso	4	0.03	6.0e-05	4.5	5.2	1.7e-07	-0.61	0.16	0.74	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	MST1R	0.02	0.00	blup	278	0.01	4.5e-02	6.0	5.2	1.8e-07	-0.91	0.05	0.93	FALSE
15	GTEx	Brain Cerebellar Hemisphere	RNF123	0.20	0.24	enet	29	0.20	7.7e-06	5.0	5.2	2.1e-07	-0.75	0.47	0.32	FALSE
16	GTEx	Brain Cerebellar Hemisphere	MST1R	0.30	0.08	enet	25	0.10	1.8e-03	5.8	5.2	2.3e-07	-0.77	0.05	0.84	FALSE
78	The Cancer Genome Atlas	Colon Adenocarcinoma	UBA7	0.11	0.06	enet	5	0.05	7.6e-04	5.1	-5.1	2.7e-07	0.71	0.15	0.84	FALSE