Hub : Genes

NHP2L1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0810 0.0300 3.3e-09 0.086 0.093 0.083 0.096 0.087 1.3e-10 1.9e-11 2.3e-10 9.9e-12 1.0e-10
2 GTEx Esophagus Muscularis 0.0690 0.0400 6.7e-03 0.017 NA -0.002 NA 0.001 3.2e-02 NA 4.2e-01 NA 2.7e-01
3 GTEx Uterus 0.1470 0.0810 5.6e-03 0.058 NA 0.016 NA 0.057 2.6e-02 NA 1.5e-01 NA 2.7e-02
4 YFS Blood 0.0187 0.0088 9.2e-05 0.004 0.013 0.012 0.014 0.008 1.1e-02 2.6e-05 7.1e-05 1.6e-05 6.4e-04
5 TCGA Prostate Adenocarcinoma 0.0364 0.0281 1.7e-03 0.014 0.021 0.015 NA 0.018 1.1e-02 2.3e-03 9.6e-03 NA 4.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.7 2.2 -0.4 -1.5 1.0 -0.6 0.2
Bipolar Disorder or Schizophrenia 0.8 1.9 7.6 -0.2 -1.1 2.8 0.9 -0.2
Depressed Affect (Nagel 2018) 4.7 9.9 16.1 -3.0 -2.3 -2.8 3.3 -4.0
Depression (Nagel 2018) 0.5 0.8 1.9 -0.3 -0.5 1.4 0.5 -1.2
Intelligence (Savage-Jansen 2018) 1.6 5.0 17.3 2.6 4.2 -0.2 0.9 0.4
Neuroticism (Nagel 2018) 6.3 14.9 25.6 -3.9 -1.9 -2.4 5.1 -4.9
Schizophrenia (2018) 1.1 2.3 7.6 0.1 -0.3 2.8 1.9 -0.5
Schizophrenia vs Biploar Disorder 0.4 0.5 1.7 0.3 0.3 0.8 1.3 -0.3
Worry (Nagel 2018) 3.8 8.0 14.4 -2.8 -1.4 -1.3 3.7 -3.8
Alzheimer’s Disease (in mother) 2.4 2.8 6.7 -2.3 2.6 0.2 1.4 -0.5
Alzheimer’s Disease (in father) 0.6 0.7 1.1 0.1 1.1 0.4 -1.0 1.0
Alzheimer’s Disease (including proxy) 0.9 1.3 4.0 -2.0 1.3 -0.3 0.6 -0.1
Crohns Disease (2017) 3.3 7.3 8.8 -3.0 -2.5 -2.3 2.8 -2.9
Irritable Bowel Disease (IBD) 1.7 4.0 7.3 -2.7 -2.4 -1.3 1.7 -1.6
Ulcerative Colitis (UC) 0.3 0.6 2.1 -1.5 -0.9 -0.1 0.4 -0.1
Major Depression (MDD) 0.2 0.3 1.0 1.0 -0.1 0.2 0.5 -0.4
Reaction Time 2.1 4.0 7.0 2.5 2.7 1.7 0.2 2.0
Verbal and Numeric Reasoning (VNR) 1.2 3.0 8.4 1.9 2.9 -1.0 1.3 0.4
Breast Cancer 0.1 0.3 0.8 0.4 -0.9 -0.1 0.3 -0.4
Ovarian Cancer 0.7 0.9 2.6 -0.1 -0.6 -1.6 0.8 -0.9
Prostate Cancer 2.7 3.8 8.1 -1.5 0.0 -1.4 2.6 -2.8
Age at First Birth 4.2 6.1 14.6 -1.9 1.2 -1.8 3.8 -2.8
Bipolar Disorder (2011) 0.7 0.7 3.3 0.0 -1.8 0.2 -0.0 -0.1
Body Mass Index (BMI) (2010) 2.3 3.2 8.7 -1.8 -3.0 -1.3 0.3 -1.4
Coronary Artery Disease (CAD) 0.3 0.3 0.8 0.9 0.0 -0.7 -0.0 0.5
Crohns Disease (2012) 2.5 4.0 7.5 -2.0 -2.7 -1.6 1.9 -1.6
Mean Putamen Volume 0.9 1.1 3.0 -1.7 1.2 -0.2 0.1 -0.9
Fasting Glucose 1.0 1.2 3.8 -2.0 -0.7 -1.1 0.5 -0.7
HbA1C 0.4 0.4 1.7 -0.1 -1.3 -0.6 -0.3 -0.1
HDL Cholesterol 0.2 0.3 0.8 -0.4 0.3 0.8 -0.9 -0.0
LDL Cholesterol 0.1 0.1 0.4 0.2 -0.6 0.3 -0.3 0.2
Lupus 0.2 0.4 0.7 0.3 -0.8 -0.8 -0.6 0.4
Neuroticism (2016) 4.6 6.6 13.5 -2.4 -1.2 -1.9 2.9 -3.7
Primary Biliary Cirrhosis 2.2 3.2 5.0 -2.1 -1.0 -0.8 2.2 -2.2
Rheumatoid Arthritis 1.9 2.7 5.3 1.4 2.3 1.3 -1.4 1.5
Schizophrenia (2014) 0.9 2.1 9.2 0.2 -0.4 3.0 1.0 0.1
Triglycerides 0.6 0.9 1.9 -0.6 -0.8 -1.4 1.3 -0.5
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.2 0.8 1.1 0.0 -0.8 0.6
Ulcerative Colitis 0.2 0.3 0.7 -0.1 -0.9 -0.5 0.1 0.7
Blood Eosinophil Count 5.1 39.6 83.5 -7.4 0.5 -2.3 9.1 -7.3
Blood Platelet Count 1.8 21.3 25.7 4.7 4.1 4.9 -5.1 4.2
Blood Red Count 0.2 1.8 5.4 2.3 0.2 1.1 -0.3 1.4
Blood White Count 0.5 3.8 13.4 2.1 1.0 3.7 0.1 -0.4
Heel T-Score 3.1 24.6 52.6 -5.5 3.6 -3.1 7.2 -4.2
BMI 0.6 3.6 11.7 -0.9 -3.4 -0.9 -1.2 -1.8
Height 0.3 5.0 17.6 -0.6 -1.4 -0.1 4.2 -2.3
Waist Hip Ratio (WHR) 0.4 2.0 5.2 1.1 1.9 -0.2 2.3 -0.0
Systolic Blood Pressure 0.2 0.9 2.8 0.6 -1.0 1.7 -0.4 -0.0
Smoking Status 3.9 9.2 14.8 3.8 3.4 1.9 -3.0 2.6
Allergy or Eczema 6.9 18.1 24.8 -4.8 -2.3 -3.6 4.9 -5.0
Cardiovascular Disease 0.4 1.5 2.6 -1.1 -1.5 -0.9 0.7 -1.6
Hypothyroidism (self reported) 3.6 8.3 15.2 3.2 1.6 2.7 -2.5 3.9
Respiratory disease 8.0 17.8 31.3 -5.6 -3.0 -3.3 4.6 -4.1
Type 2 Diabetes (T2D) (2018) 1.3 2.5 4.9 -1.6 -2.0 -2.2 0.3 -0.9
Lung FEV1/FVC ratio 0.2 1.0 2.1 0.2 -1.5 0.2 -0.8 -1.4
Lung FVC 1.2 6.2 12.0 2.4 3.5 1.5 -2.1 2.6
Neuroticism 4.1 9.9 17.5 -3.0 -1.6 -2.0 4.2 -4.1
Chronotype (morning person) 2.9 6.7 18.9 -1.7 -4.4 -1.2 2.3 -2.2
Hair Pigment 0.3 9.1 13.5 3.1 2.0 2.3 -3.7 3.7
Tanning 0.3 3.3 5.1 2.3 1.3 1.8 -1.4 2.1
Hand grip strength (left) 2.3 6.1 12.9 2.7 -3.6 1.5 -2.7 0.9
Number of treatments/medications taken 1.7 3.0 9.0 -0.9 -3.0 -2.0 1.0 -0.2
Average weekly spirits intake 3.2 4.0 7.0 2.6 -0.0 -1.0 -2.4 2.6
Sensitivity / hurt feelings 1.3 2.3 6.3 -1.3 -0.1 -0.9 2.5 -1.6
Frequency of depressed mood in last 2 weeks 1.1 1.6 4.0 -0.9 -0.6 0.0 1.6 -2.0
Hearing difficulty/problems: Yes 0.7 1.1 2.6 1.6 1.5 0.1 0.2 0.6
Relative age of first facial hair 2.3 4.7 9.2 -1.9 -0.9 -1.8 2.6 -3.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.3 -0.1 1.1 0.4 0.9 0.4
Ever used hormone-replacement therapy (HRT) 1.3 1.6 7.0 -0.3 -2.6 -0.9 0.3 -0.0
Ever had hysterectomy (womb removed) 1.2 1.3 2.2 -1.3 -0.8 -0.6 1.5 -1.3
Systolic blood pressure, automated reading 0.7 2.1 3.5 0.7 -1.7 1.5 -1.9 1.1
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 5.0 -1.2 -2.2 -1.1 -0.3 -0.7
Angina 0.3 0.4 0.9 -0.1 -0.8 0.5 0.6 0.9
Medication for hormone replacement therapy 0.7 0.8 1.9 0.7 -0.5 1.0 -1.4 0.6
Vitamin and mineral supplements 1.0 1.4 2.1 1.4 0.8 1.5 -1.2 0.8
Supplements: Zinc 1.3 1.4 2.3 -1.2 -1.2 -1.5 0.1 -1.3
Medication: Co-codamol 1.7 1.9 3.8 2.0 1.6 1.4 -0.3 1.0
Medication: Metformin 0.3 0.5 1.1 0.3 -0.4 -0.6 -1.1 0.8
Diabetes (father) 0.2 0.3 0.7 0.4 -0.8 0.8 0.3 0.1
Diabetes (mother) 5.0 6.4 9.5 2.9 2.1 3.1 -1.9 2.5
Severe depression (siblings) 1.1 1.2 3.7 -0.7 0.7 1.9 0.2 -1.1
Pack years adult smoking proportion 3.3 5.0 7.6 2.4 1.7 1.9 -2.8 2.3
Impedance of leg (right) 1.8 8.5 19.2 -4.4 1.5 -1.8 3.8 -2.0
Leg fat-free mass (left) 0.5 2.8 10.1 0.2 -3.2 -0.4 0.3 -1.9
Trunk fat percentage 4.5 18.0 24.7 -4.7 -3.2 -4.4 3.7 -5.0
Hand grip strength (right) 1.6 4.3 6.3 2.3 -2.3 1.9 -2.5 1.0
Townsend deprivation index at recruitment 0.6 0.9 2.7 1.1 1.6 0.5 0.2 -0.5
Current tobacco smoking 6.6 10.9 17.5 4.2 2.2 2.3 -3.9 3.4
Average weekly fortified wine intake 1.4 1.6 5.1 -0.8 2.3 -0.7 1.2 -0.7
Maternal smoking around birth 7.5 10.8 24.9 5.0 -0.0 2.9 -3.2 3.2
Fed-up feelings 4.9 8.9 17.5 -2.3 -2.0 -2.4 3.5 -4.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 5.0 -0.7 -0.4 0.6 1.0 -2.2
Relative age voice broke 0.4 0.6 1.3 -1.1 0.2 0.0 0.6 -1.1
Taking other prescription medications 3.2 4.9 6.2 -2.4 -2.2 -2.3 2.5 -1.7
Age when periods started (menarche) 0.6 1.5 4.8 0.7 2.2 1.3 0.3 0.8
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 0.2 -0.7 0.6 -0.4 0.4
Heel bone mineral density (BMD) T-score, automated (left) 2.8 6.4 13.0 -2.4 1.3 -2.3 3.6 -2.5
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 1.9 1.4 0.3 1.3 -0.9 1.1
Qualifications: CSEs or equivalent 1.6 2.1 4.7 -2.2 -1.4 0.0 0.5 -1.8
Serious illness, injury or assault to yourself 2.3 2.8 5.1 -1.0 -1.9 -1.6 2.3 -1.4
High blood pressure 0.1 0.4 1.2 0.3 -1.1 0.6 -0.3 -0.2
Hayfever, allergic rhinitis or eczema 6.7 14.6 19.7 -4.0 -2.7 -3.4 4.3 -4.4
Multivitamins +/- minerals 0.7 0.9 1.6 -1.0 -1.0 -1.3 0.6 -0.8
Stomach or abdominal pain in last month 1.3 1.6 6.0 0.9 -0.1 2.4 -0.8 0.5
Supplements: Glucosamine 1.0 1.3 2.7 1.2 1.1 -0.9 -0.8 1.6
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 1.9 0.8 -0.5 0.6 -1.4 1.3
Medication: Atenolol 3.1 3.9 9.1 3.0 -0.6 1.0 -1.5 2.6
Medication: Levothyroxine sodium 3.2 5.3 8.5 2.6 1.6 2.7 -1.3 2.9
Sitting height 0.1 0.5 1.4 0.1 -1.2 0.4 0.1 -1.0
Chronic bronchitis/emphysema (father) 1.3 1.5 6.7 0.1 -2.6 -0.3 -0.9 0.3
High blood pressure (mother) 1.2 1.7 3.6 0.7 -0.6 1.7 -1.9 1.1
Body mass index (BMI) 0.6 2.7 10.0 -0.3 -3.2 -0.7 -0.8 -1.4
Impedance of leg (left) 1.7 8.2 18.1 -4.3 1.1 -1.6 3.7 -2.3
Leg predicted mass (left) 0.6 3.0 10.6 0.1 -3.3 -0.5 0.3 -2.0
Trunk fat mass 2.7 11.8 17.5 -3.3 -3.4 -3.3 2.8 -4.2
Waist circumference 0.6 2.0 4.1 -0.7 -1.6 -1.1 1.4 -2.0
Number of incorrect matches in round 1.6 2.6 8.6 -1.8 -2.9 -1.1 -0.2 -0.1
Past tobacco smoking 1.5 2.7 8.1 -0.0 -2.9 0.2 -2.1 0.9
Alcohol usually taken with meals 0.6 1.0 2.5 -0.7 -1.6 -1.1 0.7 -0.6
Nervous feelings 2.6 4.9 14.9 -1.2 1.3 -0.3 3.9 -2.5
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.4 4.4 -1.7 0.7 -0.4 2.0 -2.1
Hearing difficulty/problems with background noise 0.4 0.7 2.3 1.5 0.5 -0.3 -0.3 0.7
Hair/balding pattern: Pattern 2 0.9 1.2 3.1 1.5 -0.6 1.8 -0.3 -0.0
Had menopause 0.5 0.6 2.6 -0.1 -0.2 -1.6 -0.2 0.5
Had other major operations 1.3 1.6 5.9 0.2 1.0 -2.4 0.8 -0.3
Forced vital capacity (FVC) 0.3 1.1 2.1 -1.5 0.9 -0.3 1.1 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.3 9.4 -2.4 1.1 -1.3 3.1 -1.8
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.4 0.4 -0.1 -0.4 0.6 -0.2
Qualifications: None of the above 0.8 1.8 5.8 -0.2 -0.7 0.6 -2.4 1.5
Financial difficulties in last 2 years 0.6 0.8 2.5 -0.3 1.6 0.7 0.6 -0.7
Mouth/teeth dental problems 0.6 0.9 2.1 -1.4 -0.5 -1.4 0.0 -0.6
Heart attack 0.2 0.3 0.8 -0.3 -0.9 0.4 0.0 0.7
Allergy 9.5 21.9 27.1 5.2 3.7 4.0 -5.2 5.0
Pain all over the body in last month 0.4 0.5 0.7 -0.6 -0.8 -0.8 -0.5 0.7
Diabetes (self-reported) 0.6 0.9 3.2 -0.3 -1.1 -1.8 -0.0 -0.3
Hayfever/allergic rhinitis (self-reported) 2.3 3.1 6.3 -1.7 -1.0 -0.5 2.3 -2.5
Medication: Ramipril 0.4 0.5 1.9 -0.0 -1.4 -0.7 -0.1 0.1
Medication: Simvastatin 1.4 2.1 3.5 1.9 -1.2 0.1 -1.5 1.8
Fluid intelligence score 0.9 1.9 4.6 2.1 2.1 -0.4 0.8 0.4
Illnesses of siblings 0.7 0.9 1.9 -1.0 0.4 -1.0 0.8 -1.4
Neuroticism score 4.6 9.6 18.7 -2.4 -1.6 -1.6 4.3 -4.3
Weight 1.0 4.8 12.5 -1.1 -3.5 -1.2 0.9 -2.8
Impedance of arm (right) 6.2 29.0 47.6 -6.8 1.1 -4.7 6.9 -5.2
Arm fat percentage (right) 2.3 9.2 13.4 -3.2 -2.8 -3.1 2.2 -3.7
Trunk fat-free mass 0.9 5.2 7.9 2.6 -2.7 2.8 -1.8 0.7
Hip circumference 1.3 5.5 10.6 -2.2 -2.7 -1.8 1.3 -3.2
Time employed in main current job 0.2 0.3 0.7 -0.2 0.7 0.9 -0.2 -0.1
Alcohol intake versus 10 years previously 0.3 0.4 1.1 -0.3 -1.0 0.5 0.6 -0.6
Father’s age at death 0.3 0.4 1.6 0.2 1.3 0.2 0.5 -0.3
Worrier / anxious feelings 3.9 7.3 11.7 -2.9 -1.8 -1.4 3.4 -3.4
Frequency of tiredness / lethargy in last 2 weeks 5.7 9.3 13.9 -2.5 -3.1 -1.8 3.6 -3.7
Falls in the last year 0.1 0.2 0.3 -0.4 -0.5 -0.5 0.5 0.1
Hair/balding pattern: Pattern 3 0.1 0.2 0.3 0.5 -0.0 -0.4 -0.4 0.6
Number of live births 0.6 0.9 1.3 -1.1 -0.9 -0.9 0.7 -1.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 2.5 -1.5 0.1 -0.4 1.0 -1.6
Pulse rate 0.1 0.2 0.4 0.3 0.3 0.7 -0.1 -0.4
Happiness 1.3 1.6 4.9 1.0 -0.7 0.6 2.2 -1.1
Noisy workplace 1.0 1.3 2.8 -0.3 -1.5 0.7 -1.7 0.9
Qualifications: A levels/AS levels or equivalent 1.1 2.4 11.2 0.3 3.3 0.1 0.7 -0.2
Serious illness, injury or assault of a close relative in last 2 years 4.2 4.8 6.9 2.6 1.5 2.4 -1.8 2.5
Mouth/teeth dental problems: Dentures 2.3 3.9 6.1 2.3 0.6 2.2 -1.7 2.5
Asthma 6.3 12.4 20.1 -4.4 -1.4 -2.6 4.5 -3.7
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.4 -0.3 -0.6 -0.3 0.5 0.1
Medication: Cholesterol lowering 1.2 1.8 3.5 1.3 -1.9 0.0 -1.1 1.6
Depression (self-reported) 1.7 2.1 2.7 -1.3 -1.5 -1.6 1.5 -1.3
Medication: Lansoprazole 0.1 0.2 0.6 0.2 -0.4 -0.1 0.8 0.2
Prospective memory result 1.8 2.2 6.9 -2.6 -1.0 -1.4 0.2 -1.0
Lung cancer (father) 1.2 1.4 2.5 1.3 1.6 1.2 -0.3 0.9
Illnesses of mother 0.9 1.1 4.1 0.3 2.0 0.5 -0.6 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 2.5 -1.4 0.4 -0.1 0.8 -1.6
Pulse wave Arterial Stiffness index 1.4 1.6 6.7 -0.1 -2.6 -1.0 0.3 -0.3
Impedance of arm (left) 7.4 34.0 55.5 -7.4 0.2 -5.9 7.1 -5.5
Arm fat mass (right) 1.6 6.6 11.5 -2.2 -3.4 -2.2 1.5 -3.1
Trunk predicted mass 0.9 5.2 8.0 2.6 -2.7 2.8 -1.8 0.7
Standing height 0.6 6.0 13.7 -2.1 -1.3 -0.8 3.7 -3.1
Length of working week for main job 0.4 0.5 1.4 1.2 -0.3 -0.1 -0.5 0.8
Exposure to tobacco smoke at home 0.2 0.3 1.0 -0.0 0.2 1.0 -0.6 0.3
Breastfed as a baby 3.9 4.8 9.9 -2.0 0.8 -1.8 3.1 -2.5
Tense / ‘highly strung’ 6.7 11.0 13.5 -3.1 -2.7 -3.4 3.6 -3.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.0 0.5 0.1 -0.2 1.0 -0.6
Hair/balding pattern: Pattern 4 0.3 0.8 3.3 0.2 1.8 0.1 -0.5 0.7
Birth weight of first child 1.6 2.9 12.9 0.0 -3.6 -0.0 -1.2 -0.6
Peak expiratory flow (PEF) 0.4 0.9 2.2 -0.8 -1.4 -0.1 0.3 -1.5
Pulse wave reflection index 0.9 1.1 4.7 -0.4 -2.2 -0.8 -0.3 0.2
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.5 0.2 -0.7 -0.1 0.4 -0.5
Loud music exposure frequency 1.3 1.4 3.6 -0.9 1.9 1.2 1.1 -0.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.6 0.1 1.3 0.2 0.5 -0.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 3.0 0.1 -1.7 -0.0 0.4 -0.0
Blood clot in the leg (DVT) 1.1 1.5 4.6 0.5 -2.1 -0.6 -1.3 0.6
Medication: Paracetamol 0.4 0.7 2.5 -0.1 -1.6 0.7 -0.7 -0.1
Headache pain in last month 0.8 1.3 6.2 0.4 -2.5 -0.0 -0.4 -0.1
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 2.8 -0.8 1.7 0.6 0.6 -0.7
Glaucoma (self-reported) 2.2 2.6 4.9 -2.2 1.0 -0.9 1.9 -1.6
Gout (self-reported) 1.5 2.1 5.1 -1.2 -0.8 -0.4 2.3 -1.8
Hypothyroidism/myxoedema (self-reported) 2.4 4.7 9.8 2.6 0.7 2.0 -1.6 3.1
Medication: Amlodipine 0.8 1.2 2.3 1.5 0.1 1.0 -1.4 0.7
Medication: Ventolin 100micrograms inhaler 6.9 8.8 13.9 -3.7 -0.6 -2.3 3.6 -3.5
Birth weight 1.4 3.0 7.4 1.4 -2.7 0.2 -2.0 1.3
Chronic bronchitis/emphysema (mother) 1.1 1.2 3.2 0.0 -1.8 -1.4 0.1 -1.0
High blood pressure (siblings) 0.9 1.2 2.0 0.6 -1.1 1.1 -1.2 1.4
Forced vital capacity (FVC), Best measure 0.2 0.9 2.2 -0.7 1.5 0.4 0.9 -0.8
Body fat percentage 3.2 12.5 17.6 -3.9 -2.9 -3.7 2.7 -4.2
Leg fat percentage (right) 1.1 4.0 5.3 -2.0 -2.3 -2.3 0.7 -2.2
Arm fat-free mass (right) 0.9 4.5 11.8 2.1 -3.4 1.7 -1.9 0.2
Exposure to tobacco smoke outside home 1.0 1.3 4.4 0.9 2.1 1.0 0.2 0.6
Comparative body size at age 10 4.1 11.3 26.2 3.0 -0.8 3.8 -5.1 2.4
Number of full brothers 0.5 0.6 1.3 -0.4 0.9 0.1 1.1 -0.9
Worry too long after embarrassment 1.2 2.0 7.2 -0.6 0.7 0.6 2.7 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.5 4.0 -2.0 -0.8 -1.4 1.6 -1.8
Wheeze or whistling in the chest in last year 3.0 5.4 11.6 -2.1 -0.7 -1.4 3.4 -2.9
Number of children fathered 6.0 6.7 13.5 2.2 0.8 2.5 -3.7 2.9
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.5 0.1 0.4 1.6 0.0 0.2
Age at first live birth 0.9 1.6 4.5 -0.4 0.5 -2.1 1.2 -1.3
Pulse wave peak to peak time 1.2 1.4 5.9 -0.0 2.4 0.9 0.0 0.1
Health satisfaction 0.5 0.6 1.5 1.2 -0.2 1.0 0.5 0.5
Shortness of breath walking on level ground 0.4 0.4 1.1 -0.8 0.4 1.0 0.6 0.1
Qualifications: College or University degree 1.2 3.8 8.1 0.7 2.8 -1.6 2.2 -1.6
Eye problems/disorders: None of the above 1.1 1.2 5.1 -0.3 0.7 2.3 0.3 0.6
Mouth/teeth dental problems: Loose teeth 7.9 9.4 15.8 3.5 2.8 4.0 -1.9 2.7
Emphysema/chronic bronchitis 0.3 0.4 1.0 0.2 -1.0 -0.6 -0.4 0.6
Medication for pain relief, constipation, heartburn 0.9 1.5 6.1 1.1 2.5 0.6 0.3 -0.1
Neck or shoulder pain in last month 0.1 0.1 0.3 0.2 -0.5 -0.1 0.2 0.0
Medication: Blood pressure 0.1 0.2 0.7 0.1 -0.8 -0.4 -0.4 0.5
Angina (self-reported) 0.4 0.5 1.3 0.1 -0.8 0.7 0.3 1.1
Migraine (self-reported) 1.6 2.0 4.9 -0.3 -2.2 -1.3 0.8 -1.6
Medication: Ibuprofen 0.3 0.4 0.7 -0.8 -0.8 -0.5 0.7 0.0
Medication: Allopurinol 3.2 4.3 9.2 -1.7 -1.1 -1.5 3.0 -2.4
Medication: Omeprazole 0.5 0.6 2.1 -0.7 0.2 0.3 1.5 -0.3
Medication: Seretide 50 evohaler 0.9 1.1 2.4 -1.5 0.6 0.3 1.2 -1.1
Mean time to correctly identify matches 3.6 6.9 11.5 3.4 3.4 1.3 -0.5 3.1
Heart disease (mother) 0.8 1.0 4.6 -0.0 -2.1 -0.1 0.6 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.1 -0.4 1.0 0.9 0.5 -0.3
Whole body fat mass 2.0 8.2 13.4 -2.6 -3.1 -2.6 2.1 -3.7
Leg fat mass (right) 1.1 4.1 9.0 -1.5 -3.0 -1.8 0.7 -2.4
Arm predicted mass (right) 1.0 5.3 10.8 2.5 -3.3 2.2 -2.1 0.5
Pulse rate, automated reading 0.4 1.4 4.0 0.9 2.0 1.5 -0.2 -0.2
Alcohol intake frequency. 2.3 5.3 11.2 -3.3 -2.7 -2.0 1.5 -1.4
Comparative height size at age 10 0.0 0.1 0.3 0.2 -0.0 -0.5 -0.3 0.6
Number of full sisters 2.2 2.7 6.1 1.5 0.4 2.5 -1.5 1.6
Suffer from ‘nerves’ 1.2 1.9 4.3 -0.8 -0.8 -0.0 2.0 -2.1
Overall health rating 0.3 0.7 1.2 -0.5 -1.0 0.8 1.1 -0.7
Chest pain or discomfort 0.8 1.2 4.1 0.1 -0.8 0.5 2.0 -0.9
Had major operations 0.6 0.7 1.6 1.2 0.4 0.6 0.1 1.3
Age at last live birth 1.8 2.6 5.9 -1.0 0.3 -2.4 1.5 -1.9
Family relationship satisfaction 1.2 1.5 5.0 1.0 -0.5 0.4 2.2 -1.0
Leg pain on walking 0.7 0.9 1.8 0.8 0.2 0.8 -1.2 1.3
Qualifications: NVQ or HND or HNC or equivalent 3.5 4.3 7.8 2.2 -1.3 1.5 -2.1 2.8
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.4 0.9 -0.8 1.2 -0.8 0.9
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.3 -0.5 0.6 -1.5 -0.4 -0.5
Medication: Aspirin 1.2 1.6 4.4 1.3 -0.4 -0.0 -1.4 2.1
Supplements: Vitamin C 0.1 0.1 0.3 -0.4 0.6 -0.0 -0.1 0.1
Knee pain experienced in last month 0.3 0.5 1.8 0.6 -1.3 -0.3 -0.3 0.4
Hypertension (Self-reported) 0.1 0.3 1.2 -0.0 -1.1 0.3 0.3 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 0.1 -0.6 -0.6 0.3 0.4
Illnesses of father: Heart disease 0.3 0.4 1.3 0.2 -0.3 0.7 -0.3 1.1
Illnesses of siblings: Diabetes 1.1 1.4 3.4 1.2 -0.0 0.2 -1.4 1.8
Smoking status: Previous 1.3 2.0 4.6 -0.7 1.4 -1.2 2.1 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.2 6.0 -1.2 -0.8 -0.5 1.6 -2.4
Whole body fat-free mass 0.6 3.5 10.2 1.8 -3.2 1.6 -1.1 -0.4
Leg fat-free mass (right) 0.6 3.0 11.0 0.5 -3.3 -0.1 0.1 -2.0
Arm fat percentage (left) 2.7 11.0 15.3 -3.4 -3.2 -3.5 2.4 -3.9
Average weekly red wine intake 1.5 2.2 5.6 2.4 -0.4 -0.4 -1.4 1.8
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 0.1 0.5 0.2 -0.8 0.1
Mood swings 6.4 11.6 17.8 -3.2 -3.0 -2.9 3.5 -4.2
Loneliness, isolation 2.4 3.4 6.1 -1.2 -1.5 -1.6 2.1 -2.5
Long-standing illness, disability or infirmity 0.5 0.7 2.6 -0.0 -1.6 -0.1 1.0 -0.2
Ever had bowel cancer screening 0.8 0.9 2.5 -0.1 -0.8 -0.2 -1.6 1.1
Diabetes diagnosed by doctor 0.7 1.2 3.9 -0.6 -1.2 -2.0 0.2 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.7 0.2 1.3 -0.3 0.6 -0.9
Friendships satisfaction 1.4 1.8 4.8 1.6 0.1 2.2 1.2 0.3
Qualifications: nursing, teaching 1.9 2.9 9.7 -0.8 -0.4 -3.1 1.1 -1.6
Commuting to job workplace: Walk 0.2 0.2 0.6 0.2 0.8 -0.5 0.2 -0.2
Eye problems/disorders: Cataract 1.4 1.7 8.0 -0.0 -0.2 -2.8 -0.3 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 3.7 -0.5 1.9 0.3 0.7 -0.7
Medication for cholesterol 0.5 0.8 2.4 -1.6 0.1 -0.1 0.9 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.8 0.1 -0.2 0.6 -0.9 0.4
Back pain experienced in last month 0.2 0.3 1.4 0.4 -1.2 0.4 0.1 0.1
Mineral and other dietary supplements 0.9 1.2 3.6 -0.4 0.1 0.0 1.6 -1.9
Breast cancer (self-reported) 1.4 1.7 6.2 0.5 -0.1 -2.5 1.0 -0.9
Asthma (self-reported) 7.0 13.9 21.2 -4.6 -1.7 -2.8 4.6 -4.1
Osteoporosis (self-reported) 1.3 1.6 7.8 -0.3 -2.8 0.2 0.2 0.1
Osteoarthritis (self-reported) 0.3 0.4 1.0 -0.6 0.1 -1.0 0.4 0.8
Medication: Aspirin 1.2 1.5 4.2 1.3 -0.2 0.5 -1.2 2.1
Medication: Gliclazide 0.6 0.6 1.5 0.7 -0.6 0.6 -1.2 0.7
Illnesses of father: None of the above (group 1) 0.8 1.0 1.9 1.2 1.4 -0.3 -0.9 0.8
Smoking status: Current 5.4 8.6 12.8 3.6 2.1 2.2 -3.5 2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.7 -1.3 0.3 -1.0 0.3 -0.8
Whole body water mass 0.6 3.5 10.0 1.9 -3.2 1.6 -1.2 -0.2
Leg predicted mass (right) 0.6 3.1 11.5 0.4 -3.4 -0.2 0.1 -2.0
Arm fat mass (left) 1.6 6.7 12.6 -2.2 -3.5 -2.2 1.4 -3.1
Number of self-reported non-cancer illnesses 2.6 4.6 8.2 -2.2 -2.9 -2.4 1.7 -1.1
Average weekly champagne plus white wine intake 0.2 0.2 0.5 -0.3 -0.7 0.4 0.3 0.5
Miserableness 1.4 2.4 5.6 -1.6 -0.8 -1.4 1.2 -2.4
Guilty feelings 2.8 4.1 10.2 -0.6 -0.3 0.7 3.2 -3.1
Wears glasses or contact lenses 0.8 0.9 2.5 0.1 -1.2 -1.6 0.0 -0.7
Ever taken oral contraceptive pill 0.5 0.5 1.6 0.7 0.7 1.2 -0.1 0.3
Hearing aid user 0.5 0.5 1.5 0.6 -1.2 -0.1 -0.8 -0.3
Mother’s age at death 0.5 0.6 2.6 -0.3 -0.3 -1.6 0.4 -0.2
Financial situation satisfaction 0.8 1.0 3.3 0.1 0.1 0.6 1.8 -1.2
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.2 0.2 1.1 -0.1 -0.1 0.6
Commuting to job workplace: Public transport 1.3 1.6 4.7 0.9 2.2 1.4 0.3 0.7
Eye problems/disorders: Glaucoma 1.9 2.2 6.5 -2.5 0.5 -0.6 1.5 -1.4
Medication: Blood pressure 0.1 0.2 0.5 0.7 -0.2 0.4 -0.2 0.5
Pain type(s) experienced in last month: Hip pain 1.8 2.2 4.4 2.1 0.4 1.8 -0.7 1.7
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.0 -0.5 -0.8 0.2 -1.0 0.8
High cholesterol (Self-reported) 1.0 1.7 5.5 2.4 -0.4 0.5 -0.9 1.3
Medication: Bendroflumethiazide 0.2 0.3 1.1 -0.7 -0.1 -1.0 -0.1 0.3
Medication: Paracetamol 0.5 0.8 3.4 0.0 -1.9 0.6 -0.2 -0.2
Medication: Lisinopril 0.5 0.7 1.6 -0.3 -0.7 -0.8 1.3 -0.7
Medication: Atorvastatin 0.2 0.2 0.6 0.6 -0.4 -0.8 0.3 -0.2
Illnesses of father: High blood pressure 1.9 2.3 4.3 -1.7 0.3 0.1 2.1 -2.0
Alcohol drinker status: Never 1.3 1.6 2.8 -1.3 -1.2 -0.8 1.2 -1.7
Ever smoked 1.6 2.9 10.0 0.1 3.2 -0.3 1.9 -0.9
Basal metabolic rate 0.5 2.9 11.3 1.0 -3.4 0.9 -0.5 -1.1
Leg fat percentage (left) 1.1 4.1 6.0 -1.9 -2.4 -2.2 0.7 -2.4
Arm fat-free mass (left) 0.9 4.3 8.1 2.3 -2.9 2.1 -2.0 0.4
Number of operations (self-reported) 0.4 0.6 1.4 0.5 0.2 -1.1 0.5 1.2
Average weekly beer plus cider intake 1.2 1.8 3.3 1.5 1.1 1.8 -1.1 1.1
Irritability 5.5 9.3 15.0 -2.7 -2.7 -2.5 3.3 -3.9
Risk taking 0.2 0.2 0.8 0.3 0.9 -0.4 -0.1 0.2
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.9 1.4 -0.6 0.5 -1.0 1.3
Fractured/broken bones in last 5 years 1.5 2.0 4.0 -1.4 -2.0 -1.5 0.6 -1.1
Age started oral contraceptive pill 0.9 1.1 3.4 -0.9 0.8 -1.8 0.7 -0.4
Diastolic blood pressure, automated reading 0.6 1.8 5.9 0.0 -2.4 1.4 -0.7 -1.0
Ever depressed for a whole week 0.2 0.3 0.4 0.6 0.6 0.6 0.7 0.3
Unable to work because of sickness or disability 1.5 2.0 4.4 1.1 0.4 2.1 -1.6 1.3
Commuting to job workplace: Cycle 0.5 0.6 1.1 -0.9 -1.0 -0.8 -0.1 -0.6
Myopia 2.9 4.2 11.0 1.0 3.3 1.1 -1.8 2.1
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.3 -0.7 1.5 -0.6 0.7 -0.6
Cholesterol lowering medication 0.6 0.9 3.4 1.8 -0.3 0.6 -0.5 0.8
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 7.1 -1.4 -0.0 -0.7 2.7 -1.4
Pain experienced in last month 1.7 2.9 6.2 -2.5 1.1 -1.0 1.6 -1.9
Supplements: Calcium 3.9 4.3 6.5 -1.8 -2.5 -2.5 2.1 -1.1
Basal cell carcinoma (self-reported) 7.3 8.7 16.2 -3.4 -1.2 -2.4 2.9 -4.0
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.5 -0.3 -1.2 0.3 0.1 0.7
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 4.0 0.9 -2.0 -0.0 -1.1 0.8
Heart disease (siblings) 0.3 0.3 1.0 0.2 -1.0 0.8 0.3 -0.1
Alcohol drinker status: Previous 0.6 0.7 1.3 1.2 0.6 0.4 -0.3 1.2
Pack years of smoking 4.1 6.1 9.4 2.4 2.0 1.9 -3.1 2.7
Impedance of whole body 5.3 27.0 48.5 -7.0 0.9 -4.5 6.5 -4.8
Leg fat mass (left) 0.9 3.7 8.2 -1.3 -2.9 -1.5 0.5 -2.4
Arm predicted mass (left) 0.8 4.1 8.0 2.2 -2.8 2.1 -1.8 0.4