TWAS hub - NHP2L1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0810	0.0300	3.3e-09	0.086	0.093	0.083	0.096	0.087	1.3e-10	1.9e-11	2.3e-10	9.9e-12	1.0e-10
2	GTEx	Esophagus Muscularis	0.0690	0.0400	6.7e-03	0.017	NA	-0.002	NA	0.001	3.2e-02	NA	4.2e-01	NA	2.7e-01
3	GTEx	Uterus	0.1470	0.0810	5.6e-03	0.058	NA	0.016	NA	0.057	2.6e-02	NA	1.5e-01	NA	2.7e-02
4	YFS	Blood	0.0187	0.0088	9.2e-05	0.004	0.013	0.012	0.014	0.008	1.1e-02	2.6e-05	7.1e-05	1.6e-05	6.4e-04
5	TCGA	Prostate Adenocarcinoma	0.0364	0.0281	1.7e-03	0.014	0.021	0.015	NA	0.018	1.1e-02	2.3e-03	9.6e-03	NA	4.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Allergy	9.5	21.9	27.1	5.2	3.7	4.0	-5.2	5.0
Respiratory disease	8.0	17.8	31.3	-5.6	-3.0	-3.3	4.6	-4.1
Mouth/teeth dental problems: Loose teeth	7.9	9.4	15.8	3.5	2.8	4.0	-1.9	2.7
Maternal smoking around birth	7.5	10.8	24.9	5.0	-0.0	2.9	-3.2	3.2
Impedance of arm (left)	7.4	34.0	55.5	-7.4	0.2	-5.9	7.1	-5.5
Basal cell carcinoma (self-reported)	7.3	8.7	16.2	-3.4	-1.2	-2.4	2.9	-4.0
Asthma (self-reported)	7.0	13.9	21.2	-4.6	-1.7	-2.8	4.6	-4.1
Allergy or Eczema	6.9	18.1	24.8	-4.8	-2.3	-3.6	4.9	-5.0
Medication: Ventolin 100micrograms inhaler	6.9	8.8	13.9	-3.7	-0.6	-2.3	3.6	-3.5
Hayfever, allergic rhinitis or eczema	6.7	14.6	19.7	-4.0	-2.7	-3.4	4.3	-4.4
Tense / ‘highly strung’	6.7	11.0	13.5	-3.1	-2.7	-3.4	3.6	-3.7
Current tobacco smoking	6.6	10.9	17.5	4.2	2.2	2.3	-3.9	3.4
Mood swings	6.4	11.6	17.8	-3.2	-3.0	-2.9	3.5	-4.2
Neuroticism (Nagel 2018)	6.3	14.9	25.6	-3.9	-1.9	-2.4	5.1	-4.9
Asthma	6.3	12.4	20.1	-4.4	-1.4	-2.6	4.5	-3.7
Impedance of arm (right)	6.2	29.0	47.6	-6.8	1.1	-4.7	6.9	-5.2
Number of children fathered	6.0	6.7	13.5	2.2	0.8	2.5	-3.7	2.9
Frequency of tiredness / lethargy in last 2 weeks	5.7	9.3	13.9	-2.5	-3.1	-1.8	3.6	-3.7
Irritability	5.5	9.3	15.0	-2.7	-2.7	-2.5	3.3	-3.9
Smoking status: Current	5.4	8.6	12.8	3.6	2.1	2.2	-3.5	2.9
Impedance of whole body	5.3	27.0	48.5	-7.0	0.9	-4.5	6.5	-4.8
Blood Eosinophil Count	5.1	39.6	83.5	-7.4	0.5	-2.3	9.1	-7.3
Diabetes (mother)	5.0	6.4	9.5	2.9	2.1	3.1	-1.9	2.5
Fed-up feelings	4.9	8.9	17.5	-2.3	-2.0	-2.4	3.5	-4.2
Depressed Affect (Nagel 2018)	4.7	9.9	16.1	-3.0	-2.3	-2.8	3.3	-4.0
Neuroticism (2016)	4.6	6.6	13.5	-2.4	-1.2	-1.9	2.9	-3.7
Neuroticism score	4.6	9.6	18.7	-2.4	-1.6	-1.6	4.3	-4.3
Trunk fat percentage	4.5	18.0	24.7	-4.7	-3.2	-4.4	3.7	-5.0
Age at First Birth	4.2	6.1	14.6	-1.9	1.2	-1.8	3.8	-2.8
Serious illness, injury or assault of a close relative in last 2 years	4.2	4.8	6.9	2.6	1.5	2.4	-1.8	2.5
Neuroticism	4.1	9.9	17.5	-3.0	-1.6	-2.0	4.2	-4.1
Comparative body size at age 10	4.1	11.3	26.2	3.0	-0.8	3.8	-5.1	2.4
Pack years of smoking	4.1	6.1	9.4	2.4	2.0	1.9	-3.1	2.7
Smoking Status	3.9	9.2	14.8	3.8	3.4	1.9	-3.0	2.6
Worrier / anxious feelings	3.9	7.3	11.7	-2.9	-1.8	-1.4	3.4	-3.4
Breastfed as a baby	3.9	4.8	9.9	-2.0	0.8	-1.8	3.1	-2.5
Supplements: Calcium	3.9	4.3	6.5	-1.8	-2.5	-2.5	2.1	-1.1
Worry (Nagel 2018)	3.8	8.0	14.4	-2.8	-1.4	-1.3	3.7	-3.8
Hypothyroidism (self reported)	3.6	8.3	15.2	3.2	1.6	2.7	-2.5	3.9
Mean time to correctly identify matches	3.6	6.9	11.5	3.4	3.4	1.3	-0.5	3.1
Qualifications: NVQ or HND or HNC or equivalent	3.5	4.3	7.8	2.2	-1.3	1.5	-2.1	2.8
Crohns Disease (2017)	3.3	7.3	8.8	-3.0	-2.5	-2.3	2.8	-2.9
Pack years adult smoking proportion	3.3	5.0	7.6	2.4	1.7	1.9	-2.8	2.3
Average weekly spirits intake	3.2	4.0	7.0	2.6	-0.0	-1.0	-2.4	2.6
Taking other prescription medications	3.2	4.9	6.2	-2.4	-2.2	-2.3	2.5	-1.7
Medication: Levothyroxine sodium	3.2	5.3	8.5	2.6	1.6	2.7	-1.3	2.9
Body fat percentage	3.2	12.5	17.6	-3.9	-2.9	-3.7	2.7	-4.2
Medication: Allopurinol	3.2	4.3	9.2	-1.7	-1.1	-1.5	3.0	-2.4
Heel T-Score	3.1	24.6	52.6	-5.5	3.6	-3.1	7.2	-4.2
Medication: Atenolol	3.1	3.9	9.1	3.0	-0.6	1.0	-1.5	2.6
Wheeze or whistling in the chest in last year	3.0	5.4	11.6	-2.1	-0.7	-1.4	3.4	-2.9
Chronotype (morning person)	2.9	6.7	18.9	-1.7	-4.4	-1.2	2.3	-2.2
Myopia	2.9	4.2	11.0	1.0	3.3	1.1	-1.8	2.1
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.4	13.0	-2.4	1.3	-2.3	3.6	-2.5
Guilty feelings	2.8	4.1	10.2	-0.6	-0.3	0.7	3.2	-3.1
Prostate Cancer	2.7	3.8	8.1	-1.5	0.0	-1.4	2.6	-2.8
Trunk fat mass	2.7	11.8	17.5	-3.3	-3.4	-3.3	2.8	-4.2
Arm fat percentage (left)	2.7	11.0	15.3	-3.4	-3.2	-3.5	2.4	-3.9
Nervous feelings	2.6	4.9	14.9	-1.2	1.3	-0.3	3.9	-2.5
Number of self-reported non-cancer illnesses	2.6	4.6	8.2	-2.2	-2.9	-2.4	1.7	-1.1
Crohns Disease (2012)	2.5	4.0	7.5	-2.0	-2.7	-1.6	1.9	-1.6
Alzheimer’s Disease (in mother)	2.4	2.8	6.7	-2.3	2.6	0.2	1.4	-0.5
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	9.8	2.6	0.7	2.0	-1.6	3.1
Loneliness, isolation	2.4	3.4	6.1	-1.2	-1.5	-1.6	2.1	-2.5
Body Mass Index (BMI) (2010)	2.3	3.2	8.7	-1.8	-3.0	-1.3	0.3	-1.4
Hand grip strength (left)	2.3	6.1	12.9	2.7	-3.6	1.5	-2.7	0.9
Relative age of first facial hair	2.3	4.7	9.2	-1.9	-0.9	-1.8	2.6	-3.0
Serious illness, injury or assault to yourself	2.3	2.8	5.1	-1.0	-1.9	-1.6	2.3	-1.4
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	6.3	-1.7	-1.0	-0.5	2.3	-2.5
Arm fat percentage (right)	2.3	9.2	13.4	-3.2	-2.8	-3.1	2.2	-3.7
Mouth/teeth dental problems: Dentures	2.3	3.9	6.1	2.3	0.6	2.2	-1.7	2.5
Alcohol intake frequency.	2.3	5.3	11.2	-3.3	-2.7	-2.0	1.5	-1.4
Primary Biliary Cirrhosis	2.2	3.2	5.0	-2.1	-1.0	-0.8	2.2	-2.2
Glaucoma (self-reported)	2.2	2.6	4.9	-2.2	1.0	-0.9	1.9	-1.6
Number of full sisters	2.2	2.7	6.1	1.5	0.4	2.5	-1.5	1.6
Reaction Time	2.1	4.0	7.0	2.5	2.7	1.7	0.2	2.0
Whole body fat mass	2.0	8.2	13.4	-2.6	-3.1	-2.6	2.1	-3.7
Rheumatoid Arthritis	1.9	2.7	5.3	1.4	2.3	1.3	-1.4	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	9.4	-2.4	1.1	-1.3	3.1	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	4.0	-2.0	-0.8	-1.4	1.6	-1.8
Qualifications: nursing, teaching	1.9	2.9	9.7	-0.8	-0.4	-3.1	1.1	-1.6
Eye problems/disorders: Glaucoma	1.9	2.2	6.5	-2.5	0.5	-0.6	1.5	-1.4
Illnesses of father: High blood pressure	1.9	2.3	4.3	-1.7	0.3	0.1	2.1	-2.0
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	7.1	-1.4	-0.0	-0.7	2.7	-1.4
Blood Platelet Count	1.8	21.3	25.7	4.7	4.1	4.9	-5.1	4.2
Impedance of leg (right)	1.8	8.5	19.2	-4.4	1.5	-1.8	3.8	-2.0
Prospective memory result	1.8	2.2	6.9	-2.6	-1.0	-1.4	0.2	-1.0
Age at last live birth	1.8	2.6	5.9	-1.0	0.3	-2.4	1.5	-1.9
Pain type(s) experienced in last month: Hip pain	1.8	2.2	4.4	2.1	0.4	1.8	-0.7	1.7
Irritable Bowel Disease (IBD)	1.7	4.0	7.3	-2.7	-2.4	-1.3	1.7	-1.6
Number of treatments/medications taken	1.7	3.0	9.0	-0.9	-3.0	-2.0	1.0	-0.2
Medication: Co-codamol	1.7	1.9	3.8	2.0	1.6	1.4	-0.3	1.0
Impedance of leg (left)	1.7	8.2	18.1	-4.3	1.1	-1.6	3.7	-2.3
Depression (self-reported)	1.7	2.1	2.7	-1.3	-1.5	-1.6	1.5	-1.3
Pain experienced in last month	1.7	2.9	6.2	-2.5	1.1	-1.0	1.6	-1.9
Intelligence (Savage-Jansen 2018)	1.6	5.0	17.3	2.6	4.2	-0.2	0.9	0.4
Hand grip strength (right)	1.6	4.3	6.3	2.3	-2.3	1.9	-2.5	1.0
Qualifications: CSEs or equivalent	1.6	2.1	4.7	-2.2	-1.4	0.0	0.5	-1.8
Number of incorrect matches in round	1.6	2.6	8.6	-1.8	-2.9	-1.1	-0.2	-0.1
Arm fat mass (right)	1.6	6.6	11.5	-2.2	-3.4	-2.2	1.5	-3.1
Birth weight of first child	1.6	2.9	12.9	0.0	-3.6	-0.0	-1.2	-0.6
Migraine (self-reported)	1.6	2.0	4.9	-0.3	-2.2	-1.3	0.8	-1.6
Arm fat mass (left)	1.6	6.7	12.6	-2.2	-3.5	-2.2	1.4	-3.1
Ever smoked	1.6	2.9	10.0	0.1	3.2	-0.3	1.9	-0.9
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	5.0	-1.2	-2.2	-1.1	-0.3	-0.7
Past tobacco smoking	1.5	2.7	8.1	-0.0	-2.9	0.2	-2.1	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	4.4	-1.7	0.7	-0.4	2.0	-2.1
Gout (self-reported)	1.5	2.1	5.1	-1.2	-0.8	-0.4	2.3	-1.8
Average weekly red wine intake	1.5	2.2	5.6	2.4	-0.4	-0.4	-1.4	1.8
Fractured/broken bones in last 5 years	1.5	2.0	4.0	-1.4	-2.0	-1.5	0.6	-1.1
Unable to work because of sickness or disability	1.5	2.0	4.4	1.1	0.4	2.1	-1.6	1.3
Average weekly fortified wine intake	1.4	1.6	5.1	-0.8	2.3	-0.7	1.2	-0.7
Medication: Simvastatin	1.4	2.1	3.5	1.9	-1.2	0.1	-1.5	1.8
Pulse wave Arterial Stiffness index	1.4	1.6	6.7	-0.1	-2.6	-1.0	0.3	-0.3
Birth weight	1.4	3.0	7.4	1.4	-2.7	0.2	-2.0	1.3
Friendships satisfaction	1.4	1.8	4.8	1.6	0.1	2.2	1.2	0.3
Eye problems/disorders: Cataract	1.4	1.7	8.0	-0.0	-0.2	-2.8	-0.3	-0.5
Breast cancer (self-reported)	1.4	1.7	6.2	0.5	-0.1	-2.5	1.0	-0.9
Miserableness	1.4	2.4	5.6	-1.6	-0.8	-1.4	1.2	-2.4
Type 2 Diabetes (T2D) (2018)	1.3	2.5	4.9	-1.6	-2.0	-2.2	0.3	-0.9
Sensitivity / hurt feelings	1.3	2.3	6.3	-1.3	-0.1	-0.9	2.5	-1.6
Ever used hormone-replacement therapy (HRT)	1.3	1.6	7.0	-0.3	-2.6	-0.9	0.3	-0.0
Supplements: Zinc	1.3	1.4	2.3	-1.2	-1.2	-1.5	0.1	-1.3
Stomach or abdominal pain in last month	1.3	1.6	6.0	0.9	-0.1	2.4	-0.8	0.5
Chronic bronchitis/emphysema (father)	1.3	1.5	6.7	0.1	-2.6	-0.3	-0.9	0.3
Had other major operations	1.3	1.6	5.9	0.2	1.0	-2.4	0.8	-0.3
Hip circumference	1.3	5.5	10.6	-2.2	-2.7	-1.8	1.3	-3.2
Happiness	1.3	1.6	4.9	1.0	-0.7	0.6	2.2	-1.1
Loud music exposure frequency	1.3	1.4	3.6	-0.9	1.9	1.2	1.1	-0.2
Smoking status: Previous	1.3	2.0	4.6	-0.7	1.4	-1.2	2.1	-1.3
Osteoporosis (self-reported)	1.3	1.6	7.8	-0.3	-2.8	0.2	0.2	0.1
Commuting to job workplace: Public transport	1.3	1.6	4.7	0.9	2.2	1.4	0.3	0.7
Alcohol drinker status: Never	1.3	1.6	2.8	-1.3	-1.2	-0.8	1.2	-1.7
Verbal and Numeric Reasoning (VNR)	1.2	3.0	8.4	1.9	2.9	-1.0	1.3	0.4
Lung FVC	1.2	6.2	12.0	2.4	3.5	1.5	-2.1	2.6
Ever had hysterectomy (womb removed)	1.2	1.3	2.2	-1.3	-0.8	-0.6	1.5	-1.3
High blood pressure (mother)	1.2	1.7	3.6	0.7	-0.6	1.7	-1.9	1.1
Medication: Cholesterol lowering	1.2	1.8	3.5	1.3	-1.9	0.0	-1.1	1.6
Lung cancer (father)	1.2	1.4	2.5	1.3	1.6	1.2	-0.3	0.9
Worry too long after embarrassment	1.2	2.0	7.2	-0.6	0.7	0.6	2.7	-1.3
Pulse wave peak to peak time	1.2	1.4	5.9	-0.0	2.4	0.9	0.0	0.1
Qualifications: College or University degree	1.2	3.8	8.1	0.7	2.8	-1.6	2.2	-1.6
Suffer from ‘nerves’	1.2	1.9	4.3	-0.8	-0.8	-0.0	2.0	-2.1
Family relationship satisfaction	1.2	1.5	5.0	1.0	-0.5	0.4	2.2	-1.0
Medication: Aspirin	1.2	1.6	4.4	1.3	-0.4	-0.0	-1.4	2.1
Medication: Aspirin	1.2	1.5	4.2	1.3	-0.2	0.5	-1.2	2.1
Average weekly beer plus cider intake	1.2	1.8	3.3	1.5	1.1	1.8	-1.1	1.1
Schizophrenia (2018)	1.1	2.3	7.6	0.1	-0.3	2.8	1.9	-0.5
Frequency of depressed mood in last 2 weeks	1.1	1.6	4.0	-0.9	-0.6	0.0	1.6	-2.0
Severe depression (siblings)	1.1	1.2	3.7	-0.7	0.7	1.9	0.2	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	5.0	-0.7	-0.4	0.6	1.0	-2.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.9	1.4	0.3	1.3	-0.9	1.1
Qualifications: A levels/AS levels or equivalent	1.1	2.4	11.2	0.3	3.3	0.1	0.7	-0.2
Blood clot in the leg (DVT)	1.1	1.5	4.6	0.5	-2.1	-0.6	-1.3	0.6
Chronic bronchitis/emphysema (mother)	1.1	1.2	3.2	0.0	-1.8	-1.4	0.1	-1.0
Leg fat percentage (right)	1.1	4.0	5.3	-2.0	-2.3	-2.3	0.7	-2.2
Eye problems/disorders: None of the above	1.1	1.2	5.1	-0.3	0.7	2.3	0.3	0.6
Leg fat mass (right)	1.1	4.1	9.0	-1.5	-3.0	-1.8	0.7	-2.4
Illnesses of siblings: Diabetes	1.1	1.4	3.4	1.2	-0.0	0.2	-1.4	1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	6.0	-1.2	-0.8	-0.5	1.6	-2.4
Leg fat percentage (left)	1.1	4.1	6.0	-1.9	-2.4	-2.2	0.7	-2.4
Fasting Glucose	1.0	1.2	3.8	-2.0	-0.7	-1.1	0.5	-0.7
Vitamin and mineral supplements	1.0	1.4	2.1	1.4	0.8	1.5	-1.2	0.8
Supplements: Glucosamine	1.0	1.3	2.7	1.2	1.1	-0.9	-0.8	1.6
Weight	1.0	4.8	12.5	-1.1	-3.5	-1.2	0.9	-2.8
Noisy workplace	1.0	1.3	2.8	-0.3	-1.5	0.7	-1.7	0.9
Exposure to tobacco smoke outside home	1.0	1.3	4.4	0.9	2.1	1.0	0.2	0.6
Arm predicted mass (right)	1.0	5.3	10.8	2.5	-3.3	2.2	-2.1	0.5
High cholesterol (Self-reported)	1.0	1.7	5.5	2.4	-0.4	0.5	-0.9	1.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.0	0.9	-2.0	-0.0	-1.1	0.8
Alzheimer’s Disease (including proxy)	0.9	1.3	4.0	-2.0	1.3	-0.3	0.6	-0.1
Mean Putamen Volume	0.9	1.1	3.0	-1.7	1.2	-0.2	0.1	-0.9
Schizophrenia (2014)	0.9	2.1	9.2	0.2	-0.4	3.0	1.0	0.1
Hair/balding pattern: Pattern 2	0.9	1.2	3.1	1.5	-0.6	1.8	-0.3	-0.0
Fluid intelligence score	0.9	1.9	4.6	2.1	2.1	-0.4	0.8	0.4
Trunk fat-free mass	0.9	5.2	7.9	2.6	-2.7	2.8	-1.8	0.7
Illnesses of mother	0.9	1.1	4.1	0.3	2.0	0.5	-0.6	0.8
Trunk predicted mass	0.9	5.2	8.0	2.6	-2.7	2.8	-1.8	0.7
Pulse wave reflection index	0.9	1.1	4.7	-0.4	-2.2	-0.8	-0.3	0.2
High blood pressure (siblings)	0.9	1.2	2.0	0.6	-1.1	1.1	-1.2	1.4
Arm fat-free mass (right)	0.9	4.5	11.8	2.1	-3.4	1.7	-1.9	0.2
Age at first live birth	0.9	1.6	4.5	-0.4	0.5	-2.1	1.2	-1.3
Medication for pain relief, constipation, heartburn	0.9	1.5	6.1	1.1	2.5	0.6	0.3	-0.1
Medication: Seretide 50 evohaler	0.9	1.1	2.4	-1.5	0.6	0.3	1.2	-1.1
Mineral and other dietary supplements	0.9	1.2	3.6	-0.4	0.1	0.0	1.6	-1.9
Arm fat-free mass (left)	0.9	4.3	8.1	2.3	-2.9	2.1	-2.0	0.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.9	1.4	-0.6	0.5	-1.0	1.3
Age started oral contraceptive pill	0.9	1.1	3.4	-0.9	0.8	-1.8	0.7	-0.4
Leg fat mass (left)	0.9	3.7	8.2	-1.3	-2.9	-1.5	0.5	-2.4
Bipolar Disorder or Schizophrenia	0.8	1.9	7.6	-0.2	-1.1	2.8	0.9	-0.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.9	0.8	-0.5	0.6	-1.4	1.3
Qualifications: None of the above	0.8	1.8	5.8	-0.2	-0.7	0.6	-2.4	1.5
Headache pain in last month	0.8	1.3	6.2	0.4	-2.5	-0.0	-0.4	-0.1
Medication: Amlodipine	0.8	1.2	2.3	1.5	0.1	1.0	-1.4	0.7
Heart disease (mother)	0.8	1.0	4.6	-0.0	-2.1	-0.1	0.6	-0.2
Chest pain or discomfort	0.8	1.2	4.1	0.1	-0.8	0.5	2.0	-0.9
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.4	0.9	-0.8	1.2	-0.8	0.9
Ever had bowel cancer screening	0.8	0.9	2.5	-0.1	-0.8	-0.2	-1.6	1.1
Illnesses of father: None of the above (group 1)	0.8	1.0	1.9	1.2	1.4	-0.3	-0.9	0.8
Wears glasses or contact lenses	0.8	0.9	2.5	0.1	-1.2	-1.6	0.0	-0.7
Financial situation satisfaction	0.8	1.0	3.3	0.1	0.1	0.6	1.8	-1.2
Arm predicted mass (left)	0.8	4.1	8.0	2.2	-2.8	2.1	-1.8	0.4
Ovarian Cancer	0.7	0.9	2.6	-0.1	-0.6	-1.6	0.8	-0.9
Bipolar Disorder (2011)	0.7	0.7	3.3	0.0	-1.8	0.2	-0.0	-0.1
Hearing difficulty/problems: Yes	0.7	1.1	2.6	1.6	1.5	0.1	0.2	0.6
Systolic blood pressure, automated reading	0.7	2.1	3.5	0.7	-1.7	1.5	-1.9	1.1
Medication for hormone replacement therapy	0.7	0.8	1.9	0.7	-0.5	1.0	-1.4	0.6
Multivitamins +/- minerals	0.7	0.9	1.6	-1.0	-1.0	-1.3	0.6	-0.8
Illnesses of siblings	0.7	0.9	1.9	-1.0	0.4	-1.0	0.8	-1.4
Leg pain on walking	0.7	0.9	1.8	0.8	0.2	0.8	-1.2	1.3
Diabetes diagnosed by doctor	0.7	1.2	3.9	-0.6	-1.2	-2.0	0.2	-0.5
Alzheimer’s Disease (in father)	0.6	0.7	1.1	0.1	1.1	0.4	-1.0	1.0
Triglycerides	0.6	0.9	1.9	-0.6	-0.8	-1.4	1.3	-0.5
BMI	0.6	3.6	11.7	-0.9	-3.4	-0.9	-1.2	-1.8
Townsend deprivation index at recruitment	0.6	0.9	2.7	1.1	1.6	0.5	0.2	-0.5
Age when periods started (menarche)	0.6	1.5	4.8	0.7	2.2	1.3	0.3	0.8
Body mass index (BMI)	0.6	2.7	10.0	-0.3	-3.2	-0.7	-0.8	-1.4
Leg predicted mass (left)	0.6	3.0	10.6	0.1	-3.3	-0.5	0.3	-2.0
Waist circumference	0.6	2.0	4.1	-0.7	-1.6	-1.1	1.4	-2.0
Alcohol usually taken with meals	0.6	1.0	2.5	-0.7	-1.6	-1.1	0.7	-0.6
Financial difficulties in last 2 years	0.6	0.8	2.5	-0.3	1.6	0.7	0.6	-0.7
Mouth/teeth dental problems	0.6	0.9	2.1	-1.4	-0.5	-1.4	0.0	-0.6
Diabetes (self-reported)	0.6	0.9	3.2	-0.3	-1.1	-1.8	-0.0	-0.3
Number of live births	0.6	0.9	1.3	-1.1	-0.9	-0.9	0.7	-1.0
Standing height	0.6	6.0	13.7	-2.1	-1.3	-0.8	3.7	-3.1
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.8	-0.8	1.7	0.6	0.6	-0.7
Had major operations	0.6	0.7	1.6	1.2	0.4	0.6	0.1	1.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.3	-0.5	0.6	-1.5	-0.4	-0.5
Whole body fat-free mass	0.6	3.5	10.2	1.8	-3.2	1.6	-1.1	-0.4
Leg fat-free mass (right)	0.6	3.0	11.0	0.5	-3.3	-0.1	0.1	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.7	0.2	1.3	-0.3	0.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.7	-0.5	1.9	0.3	0.7	-0.7
Medication: Gliclazide	0.6	0.6	1.5	0.7	-0.6	0.6	-1.2	0.7
Whole body water mass	0.6	3.5	10.0	1.9	-3.2	1.6	-1.2	-0.2
Leg predicted mass (right)	0.6	3.1	11.5	0.4	-3.4	-0.2	0.1	-2.0
Diastolic blood pressure, automated reading	0.6	1.8	5.9	0.0	-2.4	1.4	-0.7	-1.0
Cholesterol lowering medication	0.6	0.9	3.4	1.8	-0.3	0.6	-0.5	0.8
Alcohol drinker status: Previous	0.6	0.7	1.3	1.2	0.6	0.4	-0.3	1.2
Bipolar Disorder (2018)	0.5	0.7	2.2	-0.4	-1.5	1.0	-0.6	0.2
Depression (Nagel 2018)	0.5	0.8	1.9	-0.3	-0.5	1.4	0.5	-1.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	0.8	1.1	0.0	-0.8	0.6
Blood White Count	0.5	3.8	13.4	2.1	1.0	3.7	0.1	-0.4
Leg fat-free mass (left)	0.5	2.8	10.1	0.2	-3.2	-0.4	0.3	-1.9
Had menopause	0.5	0.6	2.6	-0.1	-0.2	-1.6	-0.2	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	3.0	0.1	-1.7	-0.0	0.4	-0.0
Number of full brothers	0.5	0.6	1.3	-0.4	0.9	0.1	1.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.5	0.1	0.4	1.6	0.0	0.2
Health satisfaction	0.5	0.6	1.5	1.2	-0.2	1.0	0.5	0.5
Medication: Omeprazole	0.5	0.6	2.1	-0.7	0.2	0.3	1.5	-0.3
Long-standing illness, disability or infirmity	0.5	0.7	2.6	-0.0	-1.6	-0.1	1.0	-0.2
Medication for cholesterol	0.5	0.8	2.4	-1.6	0.1	-0.1	0.9	-1.0
Ever taken oral contraceptive pill	0.5	0.5	1.6	0.7	0.7	1.2	-0.1	0.3
Hearing aid user	0.5	0.5	1.5	0.6	-1.2	-0.1	-0.8	-0.3
Mother’s age at death	0.5	0.6	2.6	-0.3	-0.3	-1.6	0.4	-0.2
Medication: Paracetamol	0.5	0.8	3.4	0.0	-1.9	0.6	-0.2	-0.2
Medication: Lisinopril	0.5	0.7	1.6	-0.3	-0.7	-0.8	1.3	-0.7
Basal metabolic rate	0.5	2.9	11.3	1.0	-3.4	0.9	-0.5	-1.1
Commuting to job workplace: Cycle	0.5	0.6	1.1	-0.9	-1.0	-0.8	-0.1	-0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.7	0.3	0.3	0.8	1.3	-0.3
HbA1C	0.4	0.4	1.7	-0.1	-1.3	-0.6	-0.3	-0.1
Waist Hip Ratio (WHR)	0.4	2.0	5.2	1.1	1.9	-0.2	2.3	-0.0
Cardiovascular Disease	0.4	1.5	2.6	-1.1	-1.5	-0.9	0.7	-1.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	-0.1	1.1	0.4	0.9	0.4
Relative age voice broke	0.4	0.6	1.3	-1.1	0.2	0.0	0.6	-1.1
Hearing difficulty/problems with background noise	0.4	0.7	2.3	1.5	0.5	-0.3	-0.3	0.7
Pain all over the body in last month	0.4	0.5	0.7	-0.6	-0.8	-0.8	-0.5	0.7
Medication: Ramipril	0.4	0.5	1.9	-0.0	-1.4	-0.7	-0.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.5	-1.5	0.1	-0.4	1.0	-1.6
Length of working week for main job	0.4	0.5	1.4	1.2	-0.3	-0.1	-0.5	0.8
Peak expiratory flow (PEF)	0.4	0.9	2.2	-0.8	-1.4	-0.1	0.3	-1.5
Medication: Paracetamol	0.4	0.7	2.5	-0.1	-1.6	0.7	-0.7	-0.1
Shortness of breath walking on level ground	0.4	0.4	1.1	-0.8	0.4	1.0	0.6	0.1
Angina (self-reported)	0.4	0.5	1.3	0.1	-0.8	0.7	0.3	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	-0.4	1.0	0.9	0.5	-0.3
Pulse rate, automated reading	0.4	1.4	4.0	0.9	2.0	1.5	-0.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-0.5	-0.8	0.2	-1.0	0.8
Number of operations (self-reported)	0.4	0.6	1.4	0.5	0.2	-1.1	0.5	1.2
Ulcerative Colitis (UC)	0.3	0.6	2.1	-1.5	-0.9	-0.1	0.4	-0.1
Coronary Artery Disease (CAD)	0.3	0.3	0.8	0.9	0.0	-0.7	-0.0	0.5
Height	0.3	5.0	17.6	-0.6	-1.4	-0.1	4.2	-2.3
Hair Pigment	0.3	9.1	13.5	3.1	2.0	2.3	-3.7	3.7
Tanning	0.3	3.3	5.1	2.3	1.3	1.8	-1.4	2.1
Angina	0.3	0.4	0.9	-0.1	-0.8	0.5	0.6	0.9
Medication: Metformin	0.3	0.5	1.1	0.3	-0.4	-0.6	-1.1	0.8
Forced vital capacity (FVC)	0.3	1.1	2.1	-1.5	0.9	-0.3	1.1	-0.9
Alcohol intake versus 10 years previously	0.3	0.4	1.1	-0.3	-1.0	0.5	0.6	-0.6
Father’s age at death	0.3	0.4	1.6	0.2	1.3	0.2	0.5	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.5	-1.4	0.4	-0.1	0.8	-1.6
Hair/balding pattern: Pattern 4	0.3	0.8	3.3	0.2	1.8	0.1	-0.5	0.7
Emphysema/chronic bronchitis	0.3	0.4	1.0	0.2	-1.0	-0.6	-0.4	0.6
Medication: Ibuprofen	0.3	0.4	0.7	-0.8	-0.8	-0.5	0.7	0.0
Overall health rating	0.3	0.7	1.2	-0.5	-1.0	0.8	1.1	-0.7
Knee pain experienced in last month	0.3	0.5	1.8	0.6	-1.3	-0.3	-0.3	0.4
Illnesses of father: Heart disease	0.3	0.4	1.3	0.2	-0.3	0.7	-0.3	1.1
Osteoarthritis (self-reported)	0.3	0.4	1.0	-0.6	0.1	-1.0	0.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.7	-1.3	0.3	-1.0	0.3	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.2	0.2	1.1	-0.1	-0.1	0.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.3	-0.7	1.5	-0.6	0.7	-0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	-0.3	-1.2	0.3	0.1	0.7
Heart disease (siblings)	0.3	0.3	1.0	0.2	-1.0	0.8	0.3	-0.1
Major Depression (MDD)	0.2	0.3	1.0	1.0	-0.1	0.2	0.5	-0.4
HDL Cholesterol	0.2	0.3	0.8	-0.4	0.3	0.8	-0.9	-0.0
Lupus	0.2	0.4	0.7	0.3	-0.8	-0.8	-0.6	0.4
Ulcerative Colitis	0.2	0.3	0.7	-0.1	-0.9	-0.5	0.1	0.7
Blood Red Count	0.2	1.8	5.4	2.3	0.2	1.1	-0.3	1.4
Systolic Blood Pressure	0.2	0.9	2.8	0.6	-1.0	1.7	-0.4	-0.0
Lung FEV1/FVC ratio	0.2	1.0	2.1	0.2	-1.5	0.2	-0.8	-1.4
Diabetes (father)	0.2	0.3	0.7	0.4	-0.8	0.8	0.3	0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.2	-0.7	0.6	-0.4	0.4
Heart attack	0.2	0.3	0.8	-0.3	-0.9	0.4	0.0	0.7
Time employed in main current job	0.2	0.3	0.7	-0.2	0.7	0.9	-0.2	-0.1
Exposure to tobacco smoke at home	0.2	0.3	1.0	-0.0	0.2	1.0	-0.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.5	0.1	-0.2	1.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.6	0.1	1.3	0.2	0.5	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.9	2.2	-0.7	1.5	0.4	0.9	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.1	-0.6	-0.6	0.3	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	0.1	0.5	0.2	-0.8	0.1
Commuting to job workplace: Walk	0.2	0.2	0.6	0.2	0.8	-0.5	0.2	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	0.1	-0.2	0.6	-0.9	0.4
Back pain experienced in last month	0.2	0.3	1.4	0.4	-1.2	0.4	0.1	0.1
Average weekly champagne plus white wine intake	0.2	0.2	0.5	-0.3	-0.7	0.4	0.3	0.5
Medication: Bendroflumethiazide	0.2	0.3	1.1	-0.7	-0.1	-1.0	-0.1	0.3
Medication: Atorvastatin	0.2	0.2	0.6	0.6	-0.4	-0.8	0.3	-0.2
Risk taking	0.2	0.2	0.8	0.3	0.9	-0.4	-0.1	0.2
Ever depressed for a whole week	0.2	0.3	0.4	0.6	0.6	0.6	0.7	0.3
Breast Cancer	0.1	0.3	0.8	0.4	-0.9	-0.1	0.3	-0.4
LDL Cholesterol	0.1	0.1	0.4	0.2	-0.6	0.3	-0.3	0.2
High blood pressure	0.1	0.4	1.2	0.3	-1.1	0.6	-0.3	-0.2
Sitting height	0.1	0.5	1.4	0.1	-1.2	0.4	0.1	-1.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	0.4	-0.1	-0.4	0.6	-0.2
Falls in the last year	0.1	0.2	0.3	-0.4	-0.5	-0.5	0.5	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.5	-0.0	-0.4	-0.4	0.6
Pulse rate	0.1	0.2	0.4	0.3	0.3	0.7	-0.1	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	-0.3	-0.6	-0.3	0.5	0.1
Medication: Lansoprazole	0.1	0.2	0.6	0.2	-0.4	-0.1	0.8	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	0.2	-0.7	-0.1	0.4	-0.5
Neck or shoulder pain in last month	0.1	0.1	0.3	0.2	-0.5	-0.1	0.2	0.0
Medication: Blood pressure	0.1	0.2	0.7	0.1	-0.8	-0.4	-0.4	0.5
Supplements: Vitamin C	0.1	0.1	0.3	-0.4	0.6	-0.0	-0.1	0.1
Hypertension (Self-reported)	0.1	0.3	1.2	-0.0	-1.1	0.3	0.3	-0.5
Medication: Blood pressure	0.1	0.2	0.5	0.7	-0.2	0.4	-0.2	0.5
Comparative height size at age 10	0.0	0.1	0.3	0.2	-0.0	-0.5	-0.3	0.6

Hub : Genes

NHP2L1

Models

Trait associations