Best TWAS P=1.4e-09 · Best GWAS P=6.59e-09 conditioned to 0.0128
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ERI1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 9.0e-06 | 4.8 | 5.1 | 3.0e-07 | -0.46 | 0.40 | 0.60 | FALSE |
2 | GTEx | Artery Aorta | ERI1 | 0.11 | 0.08 | lasso | 5 | 0.10 | 5.1e-06 | -5.2 | 5.4 | 5.9e-08 | -0.72 | 0.06 | 0.94 | FALSE |
3 | GTEx | Artery Tibial | ERI1 | 0.05 | 0.02 | lasso | 7 | 0.01 | 3.2e-02 | -4.9 | 5.5 | 3.3e-08 | -0.86 | 0.11 | 0.79 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | FAM86B3P | 0.28 | 0.27 | lasso | 8 | 0.28 | 5.4e-08 | -5.4 | 5.5 | 3.1e-08 | -0.76 | 0.10 | 0.88 | FALSE |
5 | GTEx | Brain Cerebellum | FAM86B3P | 0.19 | 0.14 | lasso | 5 | 0.16 | 1.8e-05 | -4.6 | 5.2 | 1.6e-07 | -0.74 | 0.24 | 0.73 | FALSE |
6 | GTEx | Brain Cortex | FAM86B3P | 0.14 | 0.05 | enet | 9 | 0.07 | 5.1e-03 | -4.8 | 5.7 | 9.5e-09 | -0.72 | 0.08 | 0.66 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | ERI1 | 0.34 | 0.35 | lasso | 7 | 0.35 | 1.9e-27 | -5.2 | 5.7 | 1.6e-08 | -0.71 | 0.12 | 0.88 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | FAM86B3P | 0.23 | 0.33 | lasso | 11 | 0.38 | 8.4e-30 | -4.5 | -5.5 | 3.3e-08 | 0.74 | 0.70 | 0.29 | FALSE |
9 | GTEx | Esophagus Mucosa | FAM86B3P | 0.22 | 0.17 | lasso | 8 | 0.19 | 1.7e-12 | -4.5 | -5.2 | 2.3e-07 | 0.75 | 0.70 | 0.30 | FALSE |
10 | GTEx | Esophagus Muscularis | ERI1 | 0.12 | 0.09 | enet | 13 | 0.08 | 7.7e-06 | -4.9 | 5.9 | 4.7e-09 | -0.81 | 0.15 | 0.85 | FALSE |
11 | GTEx | Lung | ERI1 | 0.13 | 0.07 | lasso | 6 | 0.09 | 2.7e-07 | 4.4 | 5.2 | 1.9e-07 | -0.76 | 0.22 | 0.78 | FALSE |
12 | GTEx | Muscle Skeletal | MFHAS1 | 0.07 | 0.04 | lasso | 4 | 0.04 | 1.4e-04 | -4.2 | -5.3 | 9.8e-08 | 0.80 | 0.18 | 0.80 | FALSE |
13 | GTEx | Nerve Tibial | ERI1 | 0.07 | 0.01 | enet | 16 | 0.01 | 4.2e-02 | 4.8 | 5.3 | 1.5e-07 | -0.78 | 0.15 | 0.59 | FALSE |
14 | GTEx | Pancreas | ERI1 | 0.08 | 0.00 | enet | 16 | 0.04 | 6.6e-03 | -4.7 | 6.0 | 2.5e-09 | -0.63 | 0.15 | 0.32 | FALSE |
15 | GTEx | Pituitary | FAM86B3P | 0.13 | 0.15 | lasso | 4 | 0.13 | 3.5e-04 | 5.7 | 6.1 | 1.4e-09 | -0.64 | 0.03 | 0.90 | TRUE |
16 | GTEx | Thyroid | SGK223 | 0.19 | 0.35 | enet | 16 | 0.36 | 1.1e-28 | -4.7 | 5.4 | 5.7e-08 | -0.81 | 0.71 | 0.28 | FALSE |
17 | NTR | Blood | MFHAS1 | 0.02 | 0.01 | blup | 759 | 0.01 | 2.9e-04 | -5.4 | -5.6 | 1.8e-08 | 0.81 | 0.09 | 0.91 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | FAM85B | 0.16 | 0.23 | enet | 18 | 0.22 | 1.8e-28 | -4.5 | 5.3 | 1.4e-07 | -0.74 | 0.78 | 0.21 | FALSE |
19 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ERI1 | 0.05 | 0.01 | blup | 72 | 0.01 | 5.0e-02 | -5.2 | 5.6 | 2.3e-08 | -0.60 | 0.02 | 0.60 | FALSE |
20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FLJ10661 | 0.21 | 0.26 | lasso | 9 | 0.30 | 2.3e-34 | -4.5 | 5.5 | 4.4e-08 | -0.70 | 0.55 | 0.44 | FALSE |
21 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | FLJ10661 | 0.09 | 0.07 | blup | 41 | 0.07 | 3.6e-04 | 5.2 | -5.5 | 4.4e-08 | 0.68 | 0.02 | 0.82 | FALSE |
22 | The Cancer Genome Atlas | Lung Adenocarcinoma | ERI1 | 0.06 | 0.04 | blup | 72 | 0.04 | 1.5e-05 | -5.3 | 5.9 | 2.8e-09 | -0.65 | 0.03 | 0.96 | FALSE |
23 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FLJ10661 | 0.17 | 0.11 | enet | 10 | 0.16 | 3.3e-07 | 5.5 | -5.3 | 1.3e-07 | 0.66 | 0.01 | 0.98 | FALSE |
24 | The Cancer Genome Atlas | Thyroid Carcinoma | SGK223 | 0.16 | 0.20 | enet | 14 | 0.22 | 6.1e-21 | 5.6 | 5.5 | 3.9e-08 | -0.70 | 0.01 | 0.99 | FALSE |