[Hub]/) : Traits : Asthma (self-reported) :

chr2:101,994,731-104,027,106

Best TWAS P=9.75e-63 · Best GWAS P=9.07e-51 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex IL1R1 0.14 0.09 lasso 3 0.10 4.0e-12 -5.0 5.3 8.8e-08 -0.15 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex SLC9A2 0.17 0.10 lasso 4 0.11 4.7e-13 6.9 6.9 6.3e-12 -0.23 1.00 0.00 TRUE
3 GTEx Colon Transverse IL18R1 0.14 0.00 enet 41 0.00 2.1e-01 4.0 11.6 2.6e-31 -0.40 0.04 0.48 TRUE
4 GTEx Whole Blood IL18R1 0.06 0.00 enet 14 0.01 2.1e-02 -12.7 7.3 3.5e-13 -0.24 0.17 0.05 FALSE
5 NTR Blood IL18RAP 0.14 0.16 lasso 7 0.19 1.1e-59 10.3 -6.5 8.1e-11 0.26 1.00 0.00 FALSE
6 ROSMAP Brain Pre-frontal Cortex IL1RL2 0.08 0.02 enet 33 0.03 2.3e-04 7.5 -9.8 1.1e-22 0.48 0.17 0.19 FALSE
7 YFS Blood IL18RAP 0.41 0.55 bslmm 562 0.62 4.2e-269 10.3 -7.2 8.0e-13 0.32 1.00 0.00 FALSE
8 The Cancer Genome Atlas Bladder Urothelial Carcinoma IL1RL1 0.04 0.03 lasso 7 0.03 8.1e-04 -12.8 -13.1 4.5e-39 0.50 0.25 0.12 FALSE
9 The Cancer Genome Atlas Breast Invasive Carcinoma IL18R1 0.05 0.01 blup 108 0.03 1.8e-07 -12.8 8.3 1.3e-16 -0.08 0.99 0.00 FALSE
10 The Cancer Genome Atlas Breast Invasive Carcinoma IL1RL1 0.02 0.01 blup 78 0.01 1.5e-03 12.4 -13.4 7.4e-41 0.63 0.15 0.25 FALSE
11 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IL1RL1 0.04 0.04 lasso 8 0.04 1.7e-05 -15.0 -16.1 1.7e-58 0.91 0.01 0.99 TRUE
12 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IL18R1 0.06 0.01 blup 108 0.04 2.6e-05 -2.0 -6.9 5.1e-12 0.63 0.02 0.84 FALSE
13 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IL18RAP 0.03 0.02 blup 94 0.02 1.2e-03 -12.8 13.4 1.1e-40 -0.61 0.02 0.79 FALSE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IL1RL1 0.08 0.08 enet 9 0.08 1.2e-09 -15.0 -16.4 1.1e-60 0.95 0.00 1.00 FALSE
15 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IL1RL2 0.04 0.04 enet 5 0.03 1.9e-04 -11.7 -12.1 1.6e-33 0.70 0.06 0.41 FALSE
16 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma IL1RL1 0.18 0.06 blup 78 0.15 3.7e-09 12.4 -16.0 6.2e-58 0.83 0.01 0.99 TRUE
17 The Cancer Genome Atlas Lung Adenocarcinoma IL1RL1 0.03 0.01 blup 78 0.02 4.7e-03 -14.3 -16.7 9.8e-63 0.84 0.01 0.95 TRUE
18 The Cancer Genome Atlas Pancreatic Adenocarcinoma IL1RL1 0.19 0.05 blup 78 0.10 7.1e-05 12.6 -15.2 5.1e-52 0.62 0.12 0.68 TRUE
19 The Cancer Genome Atlas Prostate Adenocarcinoma IL1R1 0.36 0.19 enet 28 0.23 1.1e-23 -10.4 7.5 4.2e-14 -0.51 0.70 0.30 TRUE
20 The Cancer Genome Atlas Thyroid Carcinoma IL1RL1 0.05 0.03 enet 6 0.03 9.7e-04 -15.0 -15.1 2.5e-51 0.98 0.00 0.99 FALSE
21 The Cancer Genome Atlas Thyroid Carcinoma SLC9A2 0.05 0.01 blup 93 0.02 8.6e-03 5.9 6.4 1.2e-10 -0.17 0.05 0.50 TRUE