Best TWAS P=3.29e-13 · Best GWAS P=6.99e-38 conditioned to 5.35e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | EPOR | 0.11 | 0.04 | lasso | 7 | 0.04 | 3.8e-04 | -7.2 | -7.1 | 1.4e-12 | 0.48 | 0.52 | 0.38 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | CARM1 | 0.11 | 0.01 | lasso | 4 | 0.00 | 6.9e-01 | -5.0 | -5.3 | 1.4e-07 | 0.35 | 0.29 | 0.04 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SMARCA4 | 0.18 | 0.03 | enet | 15 | 0.09 | 8.2e-07 | -4.5 | 6.0 | 2.3e-09 | -0.36 | 0.95 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | SMARCA4 | 0.16 | 0.00 | lasso | 6 | 0.03 | 7.2e-03 | -7.3 | 5.2 | 1.8e-07 | -0.39 | 0.17 | 0.08 | FALSE |
| 5 | GTEx | Pancreas | LDLR | 0.19 | -0.01 | enet | 5 | 0.01 | 9.7e-02 | 1.3 | -6.2 | 4.2e-10 | 0.50 | 0.02 | 0.71 | TRUE |
| 6 | NTR | Blood | SMARCA4 | 0.07 | 0.06 | lasso | 11 | 0.06 | 9.0e-18 | -5.8 | 5.8 | 7.6e-09 | -0.38 | 1.00 | 0.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | C19orf80 | 0.08 | 0.04 | enet | 17 | 0.05 | 3.1e-07 | 2.6 | 7.3 | 3.3e-13 | -0.41 | 0.65 | 0.33 | TRUE |
| 8 | YFS | Blood | SMARCA4 | 0.02 | 0.01 | enet | 3 | 0.00 | 9.2e-03 | -4.3 | 5.9 | 3.0e-09 | -0.39 | 0.15 | 0.07 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C19orf52 | 0.04 | 0.04 | blup | 27 | 0.03 | 1.7e-04 | -5.5 | 5.3 | 8.8e-08 | -0.37 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SPC24 | 0.06 | 0.00 | enet | 15 | 0.01 | 1.4e-02 | -9.9 | 7.3 | 3.7e-13 | -0.35 | 0.00 | 0.55 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | C19orf52 | 0.05 | 0.06 | lasso | 4 | 0.06 | 2.5e-06 | -4.9 | 5.5 | 4.2e-08 | -0.36 | 0.01 | 0.99 | FALSE |