TWAS hub - C19orf52

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0422	0.0260	5.8e-05	0.044	0.031	0.027	NA	0.030	9.1e-06	1.7e-04	0.00050	NA	2.5e-04
2	TCGA	Brain Lower Grade Glioma	0.0521	0.0403	3.5e-03	0.035	0.004	0.010	NA	0.021	6.2e-05	9.8e-02	0.02000	NA	1.6e-03
3	TCGA	Thyroid Carcinoma	0.0450	0.0260	5.1e-06	0.062	0.056	0.028	NA	0.058	1.1e-06	3.6e-06	0.00082	NA	2.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
LDL Cholesterol	55.8	88.3	121.0	11.0	7.0	9.8
High cholesterol (Self-reported)	32.8	58.2	75.2	8.7	5.8	8.1
Cholesterol lowering medication	18.2	26.7	36.1	6.0	3.3	5.8
Medication: Simvastatin	15.0	22.0	30.0	5.3	2.7	5.5
Medication: Cholesterol lowering	13.3	20.7	28.7	5.4	2.5	5.2
Primary Biliary Cirrhosis	11.0	15.6	20.3	4.4	2.7	4.5
Medication: Atorvastatin	10.6	13.1	17.2	4.2	2.7	3.9
Cardiovascular Disease	8.8	29.2	41.1	6.4	3.3	6.0
Osteoarthritis (self-reported)	8.5	11.0	12.9	-3.1	-3.6	-3.2
Asthma	8.4	16.6	23.2	-4.5	-2.6	-4.8
Coronary Artery Disease (CAD)	8.0	9.6	13.0	3.5	1.9	3.6
Heart disease (mother)	7.7	9.4	12.3	3.5	2.6	3.1
Bipolar Disorder (2018)	7.5	11.8	12.6	3.5	3.4	3.4
Medication for cholesterol, blood pressure or diabetes	7.4	12.3	17.4	-4.2	-1.6	-4.1
Asthma (self-reported)	6.9	13.8	19.4	-4.0	-2.4	-4.4
Reaction Time	6.8	12.9	17.5	3.6	2.9	4.2
Illnesses of father: Heart disease	6.7	9.2	15.2	3.9	1.5	3.2
Medication: Levothyroxine sodium	5.6	9.6	12.9	3.3	2.2	3.6
Ever depressed for a whole week	5.4	6.6	8.4	2.9	2.0	2.7
Medication: Aspirin	5.3	6.9	10.6	2.7	1.7	3.3
Heart disease (siblings)	5.3	6.5	9.0	2.4	2.2	3.0
Illnesses of father: None of the above (group 1)	4.8	6.0	7.7	-2.8	-1.8	-2.6
Hypothyroidism/myxoedema (self-reported)	4.7	9.2	13.0	3.3	1.9	3.6
Mean time to correctly identify matches	4.6	8.9	13.0	3.1	2.0	3.6
Bipolar Disorder (2011)	4.5	4.4	6.6	1.6	2.6	2.0
Commuting to job workplace: Public transport	4.5	5.3	10.8	-1.2	-3.3	-1.9
Illnesses of mother	4.4	5.4	6.0	-2.4	-2.4	-2.1
Severe depression (siblings)	4.3	4.8	8.2	2.4	0.8	2.9
Medication: Aspirin	4.3	5.6	9.4	2.6	0.9	3.1
Alcohol drinker status: Previous	4.2	4.8	7.0	2.0	2.6	1.9
Hypothyroidism (self reported)	4.0	9.3	12.9	3.1	2.2	3.6
Number of full brothers	4.0	5.0	7.7	1.8	2.8	2.0
Long-standing illness, disability or infirmity	4.0	6.2	8.8	2.6	1.8	3.0
Stomach or abdominal pain in last month	3.9	4.9	7.3	-1.9	-2.7	-1.9
Pain experienced in last month	3.9	6.5	6.7	2.5	2.6	2.6
Blood Eosinophil Count	3.4	26.1	39.1	-5.5	-3.0	-6.2
Diverticular disease/diverticulitis (self-reported)	3.4	4.1	9.4	-1.2	-3.1	-1.2
Illnesses of siblings: Diabetes	3.4	4.2	5.1	1.6	2.2	2.3
Respiratory disease	3.3	7.4	11.7	-3.1	-1.1	-3.4
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.6	8.1	-2.5	-2.3	-2.8
Major Depression (MDD)	3.1	3.7	7.0	2.0	0.0	2.6
Medication: Atenolol	3.1	3.9	4.2	1.9	2.1	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	10.0	16.1	-3.3	-1.8	-4.0
High blood pressure (siblings)	3.1	4.5	5.9	2.4	1.6	2.2
Number of full sisters	3.1	3.7	4.4	1.8	2.1	1.9
Medication for cholesterol	3.1	4.7	6.4	-2.5	-1.5	-2.3
Illnesses of siblings	3.0	4.3	5.6	-1.8	-2.0	-2.4
Forced vital capacity (FVC), Best measure	3.0	11.0	17.2	-3.6	-1.8	-4.1
Pulse rate, automated reading	3.0	9.6	18.9	-2.3	-4.3	-2.1
Fed-up feelings	2.9	5.2	6.6	-2.0	-2.6	-2.2
Age when periods started (menarche)	2.9	7.1	10.9	-3.2	-0.1	-3.3
HDL Cholesterol	2.8	4.6	8.7	-1.3	-3.0	-1.9
Family relationship satisfaction	2.7	3.3	5.9	-1.8	-0.8	-2.4
Forced expiratory volume in 1-second (FEV1)	2.5	8.6	15.2	-2.9	-1.5	-3.9
Birth weight of first child	2.5	4.5	5.3	-1.8	-2.3	-2.3
Forced vital capacity (FVC)	2.4	9.4	15.5	-3.3	-1.2	-3.9
Allergy	2.4	5.5	8.7	2.8	-0.3	2.9
Schizophrenia vs Biploar Disorder	2.3	3.0	7.7	-0.8	-2.8	-0.8
Alzheimer’s Disease (in mother)	2.3	2.7	7.3	0.0	2.7	0.8
Bilateral oophorectomy (both ovaries removed)	2.3	2.6	4.3	-1.7	-0.9	-2.1
Hearing difficulty/problems with background noise	2.3	3.6	6.8	1.4	2.6	1.4
Wheeze or whistling in the chest in last year	2.3	4.0	6.0	-2.3	-1.0	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	4.6	1.6	1.0	2.1
Emphysema/chronic bronchitis	2.3	2.6	2.8	1.5	1.7	1.6
Tinnitus: Yes, now most or all of the time	2.3	2.7	3.8	-1.5	-1.9	-1.4
Blood White Count	2.2	16.0	17.8	-3.8	-4.2	-4.0
Heart attack	2.1	2.6	3.8	1.4	1.5	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	5.1	-1.9	-2.2	-2.2
Vascular/heart problems diagnosed by doctor	2.0	5.5	7.5	-2.7	-1.3	-2.7
Waist Hip Ratio (WHR)	1.9	8.4	14.9	1.8	3.9	2.6
Number of self-reported non-cancer illnesses	1.9	3.2	5.3	1.5	1.4	2.3
Knee pain experienced in last month	1.8	2.8	5.9	-0.5	-2.4	-1.5
Triglycerides	1.7	2.8	5.6	0.9	2.4	1.4
Number of treatments/medications taken	1.7	3.1	4.4	1.8	1.3	2.1
High blood pressure (mother)	1.7	2.4	4.0	2.0	0.5	1.8
Had other major operations	1.7	2.0	2.9	-1.1	-1.4	-1.7
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	2.9	-1.7	-1.2	-1.6
Medication: Ramipril	1.7	2.2	4.1	1.6	0.4	2.0
Standing height	1.7	17.1	27.8	-4.8	-0.9	-5.3
Peak expiratory flow (PEF)	1.7	3.9	5.1	-1.9	-1.7	-2.2
Systolic blood pressure, automated reading	1.6	4.6	7.0	2.6	0.2	2.6
Vitamin and mineral supplements	1.6	2.1	4.5	1.0	2.1	0.9
Trunk fat-free mass	1.6	9.2	13.5	-2.9	-2.4	-3.7
Trunk predicted mass	1.6	8.9	13.0	-2.8	-2.4	-3.6
Medication: Ventolin 100micrograms inhaler	1.6	2.0	2.9	-1.4	-1.2	-1.7
Medication: Blood pressure	1.6	2.9	4.9	1.9	0.5	2.2
Angina (self-reported)	1.6	2.1	2.7	1.6	1.1	1.6
Medication: Omeprazole	1.6	1.9	3.2	1.5	0.6	1.8
Friendships satisfaction	1.6	2.0	3.2	-0.9	-1.8	-1.4
Medication: Paracetamol	1.6	2.4	3.3	-1.5	-1.3	-1.8
Fractured/broken bones in last 5 years	1.6	2.0	2.7	-1.1	-1.6	-1.5
Ovarian Cancer	1.5	2.0	5.4	-0.1	2.3	0.8
Medication: Co-codamol	1.5	1.7	2.4	1.1	1.6	1.2
Current tobacco smoking	1.5	2.4	4.9	-1.1	-2.2	-1.1
Shortness of breath walking on level ground	1.5	1.8	4.7	-0.7	-2.2	-0.6
Hypertension (Self-reported)	1.5	4.1	6.2	2.5	0.6	2.4
Breast cancer (self-reported)	1.5	1.8	3.6	1.9	-0.1	1.3
Average weekly beer plus cider intake	1.5	2.1	3.4	-1.2	1.8	-1.2
Heart attack/myocardial infarction (self-reported)	1.5	2.0	3.4	1.3	1.0	1.9
Bipolar Disorder or Schizophrenia	1.4	3.5	5.7	2.4	0.1	2.2
Height	1.4	26.9	43.3	-6.1	0.0	-6.6
Average weekly spirits intake	1.4	1.8	2.0	-1.3	-1.4	-1.3
Angina	1.4	1.9	2.4	1.5	0.9	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	3.3	-1.8	-0.1	-1.5
High blood pressure	1.4	4.0	6.2	2.5	0.5	2.3
Neck or shoulder pain in last month	1.4	2.0	4.4	-0.9	-2.1	-0.9
Smoking status: Current	1.4	2.3	5.1	-0.9	-2.2	-1.0
Arm fat-free mass (right)	1.3	6.5	8.1	-2.3	-2.5	-2.9
Exposure to tobacco smoke outside home	1.3	1.7	3.5	-0.9	-1.9	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	2.1	0.8	1.5	1.4
Overall health rating	1.3	2.8	6.0	-0.9	-2.4	-1.3
Ever smoked	1.3	2.3	3.1	-1.7	-1.0	-1.8
Arm predicted mass (left)	1.3	6.4	8.4	-2.2	-2.4	-2.9
Schizophrenia (2014)	1.2	2.6	3.3	1.4	-1.8	1.6
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.1	-1.5	-0.8	-1.2
Systolic Blood Pressure	1.2	5.8	7.8	2.8	1.7	2.6
Hayfever, allergic rhinitis or eczema	1.2	2.7	3.8	-1.7	1.2	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	1.4	1.1	1.2	1.1
Schizophrenia (2018)	1.1	2.2	6.7	0.2	-2.6	0.1
Fasting Glucose	1.1	1.3	2.2	-1.5	-0.3	-1.2
Average weekly fortified wine intake	1.1	1.2	2.2	1.0	0.8	1.5
Hip circumference	1.1	4.9	11.2	-0.8	-3.3	-1.7
Depression (self-reported)	1.1	1.3	2.0	1.1	0.7	1.4
Prospective memory result	1.1	1.4	1.9	1.4	0.7	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	2.1	1.1	1.2	1.5
Blood clot in the leg (DVT)	1.1	1.4	1.7	0.9	1.2	1.3
Migraine (self-reported)	1.1	1.3	2.2	-1.3	0.0	-1.5
Alcohol intake frequency.	1.1	2.6	3.0	1.4	1.7	1.7
Whole body fat-free mass	1.1	6.4	8.8	-2.3	-2.3	-3.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	2.3	-1.5	-1.0	-1.3
Whole body water mass	1.1	6.0	8.2	-2.2	-2.3	-2.9
Arm fat-free mass (left)	1.1	5.5	7.2	-2.0	-2.3	-2.7
Supplements: Calcium	1.1	1.2	1.8	1.4	0.5	1.2
Depressed Affect (Nagel 2018)	1.0	2.2	3.9	-1.2	-2.0	-1.1
Neuroticism (2016)	1.0	1.4	2.3	-1.5	0.2	-1.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.4	-0.9	-0.9	-1.2
Number of incorrect matches in round	1.0	1.6	3.0	-1.7	0.1	-1.3
Pain all over the body in last month	1.0	1.1	1.7	-1.3	-0.6	-1.1
Leg pain on walking	1.0	1.2	3.5	-0.0	-1.9	0.3
Eye problems/disorders: Cataract	1.0	1.1	1.9	0.9	0.9	1.4
Medication: Blood pressure	1.0	1.9	2.7	1.6	0.9	1.5
Risk taking	1.0	1.4	2.1	1.3	0.7	1.5
Basal cell carcinoma (self-reported)	1.0	1.2	3.4	-0.0	1.8	0.5
Alzheimer’s Disease (including proxy)	0.9	1.3	3.7	-0.1	1.9	0.5
Neuroticism	0.9	2.1	3.9	-2.0	-0.0	-1.6
Chronotype (morning person)	0.9	2.0	2.3	1.2	1.5	1.5
Hearing difficulty/problems: Yes	0.9	1.4	1.7	-1.3	0.9	-1.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.8	1.3	-0.1	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.2	-0.7	-1.5	-0.8
Number of children fathered	0.9	1.1	3.1	-0.0	1.8	0.3
Qualifications: College or University degree	0.9	2.7	3.6	1.8	1.2	1.9
Arm predicted mass (right)	0.9	4.4	5.7	-1.8	-2.0	-2.4
Ever had bowel cancer screening	0.9	1.0	2.0	1.1	-0.0	1.4
Commuting to job workplace: Walk	0.9	1.0	1.1	1.1	1.0	0.9
Basal metabolic rate	0.9	5.2	6.7	-1.9	-2.3	-2.6
Medication: Metformin	0.8	1.2	1.6	1.0	-1.3	1.0
Qualifications: CSEs or equivalent	0.8	1.0	1.8	-1.0	-0.3	-1.4
Nervous feelings	0.8	1.5	3.4	0.4	1.9	0.9
Weight	0.8	4.1	6.5	-1.4	-2.5	-2.0
Impedance of arm (left)	0.8	3.7	7.9	1.0	2.8	1.5
Tense / ‘highly strung’	0.8	1.4	2.8	-1.7	0.3	-1.1
Medication: Paracetamol	0.8	1.3	1.8	-1.3	-0.8	-1.4
Headache pain in last month	0.8	1.4	2.5	-1.6	0.7	-1.0
Gout (self-reported)	0.8	1.1	1.6	-0.4	-1.2	-1.3
Age at last live birth	0.8	1.1	2.6	0.6	1.6	0.7
Loneliness, isolation	0.8	1.2	3.2	-0.1	-1.8	-0.6
Diabetes diagnosed by doctor	0.8	1.3	3.5	0.3	-1.9	0.4
Medication: Lisinopril	0.8	1.0	2.0	1.4	-0.1	1.0
Neuroticism (Nagel 2018)	0.7	1.6	2.9	-1.7	-0.1	-1.4
Crohns Disease (2017)	0.7	1.5	2.6	0.8	1.6	1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.4	0.3	-1.9	0.4
Tanning	0.7	8.1	11.7	2.9	2.0	3.4
Leg fat-free mass (left)	0.7	3.6	5.3	-1.3	-2.3	-2.0
Multivitamins +/- minerals	0.7	0.9	2.6	-0.4	-1.6	-0.2
Leg predicted mass (left)	0.7	3.8	5.3	-1.4	-2.3	-2.0
Had menopause	0.7	0.9	1.3	0.9	0.8	1.1
Diabetes (self-reported)	0.7	1.1	3.1	-0.2	-1.8	-0.1
Breastfed as a baby	0.7	0.9	1.4	0.9	0.6	1.2
Comparative body size at age 10	0.7	2.0	2.7	1.6	-1.1	1.5
Age at first live birth	0.7	1.2	2.7	0.7	1.6	0.6
Health satisfaction	0.7	0.9	1.3	1.1	-0.4	1.1
Medication: Ibuprofen	0.7	0.9	1.2	-0.8	-1.1	-0.9
Had major operations	0.7	0.8	2.0	-0.3	-1.4	-0.5
Mineral and other dietary supplements	0.7	1.0	2.9	0.1	1.7	0.2
Osteoporosis (self-reported)	0.7	0.8	1.6	-0.7	-1.3	-0.6
Medication: Gliclazide	0.7	0.8	1.2	1.1	0.3	1.0
Irritability	0.7	1.1	2.3	-1.5	0.3	-1.0
Body Mass Index (BMI) (2010)	0.6	0.9	1.0	-1.0	-0.7	-1.0
Serious illness, injury or assault to yourself	0.6	0.7	1.8	0.4	-1.4	0.4
Alcohol usually taken with meals	0.6	0.9	1.3	1.0	-0.7	1.1
Worrier / anxious feelings	0.6	1.1	1.7	-1.3	1.1	-0.7
Loud music exposure frequency	0.6	0.7	1.0	-1.0	-0.8	-0.6
Pulse wave peak to peak time	0.6	0.7	1.5	-0.7	0.2	-1.2
Leg fat-free mass (right)	0.6	3.2	4.0	-1.4	-1.9	-2.0
Back pain experienced in last month	0.6	0.9	1.5	-1.0	-0.4	-1.2
Leg predicted mass (right)	0.6	3.3	4.1	-1.4	-2.0	-2.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.3	0.9	-0.4	1.1
Pack years of smoking	0.6	0.8	1.3	-1.1	1.1	-0.3
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.2	-1.5	1.0	-1.2
Irritable Bowel Disease (IBD)	0.5	1.2	3.2	0.2	1.8	0.7
Prostate Cancer	0.5	0.7	1.3	-1.1	0.3	-0.9
Crohns Disease (2012)	0.5	0.9	1.5	0.8	1.2	0.7
BMI	0.5	2.9	8.5	0.4	-2.9	0.0
Hair Pigment	0.5	13.8	18.1	4.0	2.7	4.3
Sensitivity / hurt feelings	0.5	0.9	1.2	-1.0	1.1	-0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	0.7	0.8	0.8	0.9
Pack years adult smoking proportion	0.5	0.8	1.6	-1.3	0.8	-0.4
Body mass index (BMI)	0.5	2.1	5.6	0.7	-2.4	0.3
Impedance of leg (left)	0.5	2.5	6.2	-1.1	2.5	-0.6
Hair/balding pattern: Pattern 2	0.5	0.6	0.8	0.9	0.5	0.9
Impedance of arm (right)	0.5	2.5	6.6	0.4	2.6	0.8
Number of live births	0.5	0.7	1.6	0.5	0.6	1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	0.9	-0.9	-0.9	-0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.4	1.2	-0.2	0.8
Glaucoma (self-reported)	0.5	0.6	0.9	-0.7	-0.6	-0.9
Birth weight	0.5	1.1	1.3	-1.1	-1.2	-0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	-0.5	-1.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	1.4	0.6	0.5	1.2
Comparative height size at age 10	0.5	2.7	4.1	-2.0	0.7	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.7	0.6	0.9	0.8
Mood swings	0.5	0.8	2.0	-1.4	0.2	-0.7
Average weekly champagne plus white wine intake	0.5	0.7	1.6	0.5	-1.3	0.5
Hearing aid user	0.5	0.5	1.0	-0.8	0.2	-1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.8	-0.1	-1.4	0.1
Myopia	0.5	0.7	1.7	-1.3	-0.1	-0.7
Impedance of whole body	0.5	2.5	7.0	0.1	2.6	0.6
Worry (Nagel 2018)	0.4	0.9	1.3	-1.1	1.0	-0.6
Ulcerative Colitis (UC)	0.4	0.7	1.7	-0.5	1.3	-0.3
Blood Platelet Count	0.4	4.7	7.6	-0.9	-2.8	-2.4
Allergy or Eczema	0.4	1.1	1.3	-0.9	1.1	-1.2
Hand grip strength (left)	0.4	1.1	2.3	-0.5	1.5	-0.9
Medication for hormone replacement therapy	0.4	0.4	1.0	-1.0	0.3	-0.3
Sitting height	0.4	3.1	5.2	-2.0	-0.3	-2.3
Qualifications: None of the above	0.4	0.8	1.1	-1.0	-0.6	-0.9
Time employed in main current job	0.4	0.5	0.8	-0.7	-0.9	-0.4
Pulse rate	0.4	0.6	1.2	0.3	-1.1	0.7
Happiness	0.4	0.4	0.8	-0.9	-0.3	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.3	0.4	1.1	0.1
Leg fat mass (right)	0.4	1.5	4.4	0.0	-2.1	-0.4
Arm fat percentage (left)	0.4	1.5	1.9	1.4	-1.2	1.0
Wears glasses or contact lenses	0.4	0.4	0.8	0.9	0.1	0.7
Eye problems/disorders: Glaucoma	0.4	0.5	0.7	0.7	0.8	0.5
Illnesses of father: High blood pressure	0.4	0.5	0.8	0.5	0.5	0.9
Alcohol drinker status: Never	0.4	0.5	0.8	0.9	0.6	0.5
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.6	-0.8	-0.3
Age at First Birth	0.3	0.4	0.5	-0.5	0.7	-0.7
Rheumatoid Arthritis	0.3	0.4	0.6	-0.8	0.7	-0.5
Ulcerative Colitis	0.3	0.4	0.7	-0.5	0.8	-0.5
Lung FVC	0.3	1.6	2.8	-1.0	-0.9	-1.7
Diabetes (father)	0.3	0.3	0.4	-0.7	-0.6	-0.4
Diabetes (mother)	0.3	0.4	0.9	1.0	-0.0	0.6
Impedance of leg (right)	0.3	1.6	3.2	-1.0	1.8	-0.7
Supplements: Glucosamine	0.3	0.4	0.9	-0.1	-1.0	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.5	1.2	0.7	0.4
Mouth/teeth dental problems	0.3	0.5	1.4	0.1	1.2	-0.3
Arm fat percentage (right)	0.3	1.2	2.0	1.0	-1.4	0.7
Falls in the last year	0.3	0.5	0.6	0.7	0.6	0.8
Hair/balding pattern: Pattern 3	0.3	0.5	1.3	0.1	1.2	0.1
Medication: Lansoprazole	0.3	0.3	0.8	0.1	-0.9	-0.4
Arm fat mass (right)	0.3	1.2	3.4	0.1	-1.8	-0.5
Length of working week for main job	0.3	0.4	0.8	-0.6	-0.0	-0.9
Exposure to tobacco smoke at home	0.3	0.3	0.5	0.7	0.5	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	0.6	0.4	0.8
Leg fat percentage (right)	0.3	1.1	2.1	0.9	-1.5	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.5	0.5	0.5	0.7
Chest pain or discomfort	0.3	0.4	0.8	0.9	-0.2	0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	0.7	0.3	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.4	-0.7	-0.6	0.3
Arm fat mass (left)	0.3	1.2	3.5	0.4	-1.9	-0.2
Financial situation satisfaction	0.3	0.4	0.8	0.4	0.9	-0.3
Age started oral contraceptive pill	0.3	0.4	0.8	-0.4	-0.2	-0.9
Diastolic blood pressure, automated reading	0.3	0.8	1.3	0.7	-1.1	0.8
Commuting to job workplace: Cycle	0.3	0.4	0.6	0.4	0.7	0.8
Leg fat mass (left)	0.3	1.1	3.1	0.1	-1.8	-0.3
HbA1C	0.2	0.3	0.7	0.1	-0.8	0.3
Lung FEV1/FVC ratio	0.2	0.9	1.9	0.9	-1.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.8	0.1	0.2	0.9
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	-0.8	0.3	-0.0
Hand grip strength (right)	0.2	0.5	0.7	-0.6	0.5	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.2	0.5	-0.6
Trunk fat mass	0.2	0.8	2.2	-0.2	-1.5	-0.6
Waist circumference	0.2	0.7	2.0	0.4	-1.4	0.1
Past tobacco smoking	0.2	0.3	0.4	0.5	0.5	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.9	0.3	0.9	0.2
Neuroticism score	0.2	0.4	0.9	-0.9	0.5	-0.3
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.5	0.8	0.3
Father’s age at death	0.2	0.3	0.5	-0.7	0.3	-0.4
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	0.2	-0.5	0.7
Pulse wave reflection index	0.2	0.2	0.6	0.0	-0.8	-0.3
Body fat percentage	0.2	0.8	1.0	0.9	-1.0	0.8
Medication for pain relief, constipation, heartburn	0.2	0.4	0.5	-0.7	0.3	-0.7
Medication: Allopurinol	0.2	0.2	0.6	0.0	0.0	-0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.3	0.5	-0.5	-0.3
Whole body fat mass	0.2	0.8	2.3	0.0	-1.5	-0.4
Suffer from ‘nerves’	0.2	0.2	0.5	-0.4	0.7	-0.3
Smoking status: Previous	0.2	0.3	0.6	-0.8	0.0	-0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.6	0.1	0.4
Leg fat percentage (left)	0.2	0.8	1.1	0.8	-1.0	0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	0.4	0.5	0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.2	-0.2	-0.5	-0.5
Breast Cancer	0.1	0.2	0.5	0.1	-0.2	0.7
Lupus	0.1	0.1	0.1	-0.4	0.3	-0.3
Blood Red Count	0.1	1.2	2.1	-0.3	-1.1	-1.4
Smoking Status	0.1	0.2	0.3	-0.4	-0.5	-0.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.3	0.2	-0.6
Trunk fat percentage	0.1	0.5	0.8	0.7	-0.9	0.6
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.3	-0.6	-0.3
Maternal smoking around birth	0.1	0.1	0.2	0.1	-0.4	0.3
Relative age voice broke	0.1	0.1	0.3	0.0	-0.5	0.1
Taking other prescription medications	0.1	0.2	0.2	0.4	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	0.4	0.9	-0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.1	0.4	0.4
Financial difficulties in last 2 years	0.1	0.2	0.4	-0.1	-0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.2	0.3	0.6
Noisy workplace	0.1	0.2	0.3	0.5	-0.2	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	-0.4	-0.6	-0.6
Lung cancer (father)	0.1	0.2	0.5	-0.7	-0.2	-0.0
Hair/balding pattern: Pattern 4	0.1	0.1	0.3	0.4	-0.5	0.1
Medication: Amlodipine	0.1	0.1	0.3	-0.3	-0.2	-0.6
Worry too long after embarrassment	0.1	0.2	0.4	-0.3	0.7	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	0.3	0.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	-0.2	0.2	0.3
Average weekly red wine intake	0.1	0.2	0.6	0.1	-0.8	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.2	0.4	-0.5
Miserableness	0.1	0.2	0.3	-0.5	-0.6	0.2
Ever taken oral contraceptive pill	0.1	0.1	0.1	0.1	-0.3	-0.4
Mother’s age at death	0.1	0.1	0.2	0.1	-0.0	-0.4
Number of operations (self-reported)	0.1	0.1	0.2	0.5	0.3	0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.1	0.3	0.3
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.0	-0.4	0.3
Depression (Nagel 2018)	0.0	0.0	0.0	0.2	0.1	0.2
Mean Putamen Volume	0.0	0.0	0.0	0.2	-0.0	-0.0
Heel T-Score	0.0	0.3	0.8	-0.1	0.3	-0.9
Relative age of first facial hair	0.0	0.1	0.1	0.2	0.3	-0.0
Supplements: Zinc	0.0	0.0	0.0	-0.2	0.1	0.0
Fluid intelligence score	0.0	0.0	0.1	0.0	0.2	0.2
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	-0.1	-0.2	0.4
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.3	-0.2	-0.1
Supplements: Vitamin C	0.0	0.1	0.1	0.2	-0.3	0.2
Qualifications: nursing, teaching	0.0	0.1	0.1	-0.1	-0.3	-0.3
Guilty feelings	0.0	0.0	0.1	0.3	-0.2	-0.2
Medication: Bendroflumethiazide	0.0	0.1	0.1	-0.2	-0.3	0.2

Hub : Genes

C19orf52

Models

Trait associations