Hub : Genes

SPC24

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1400 0.0500 4.6e-03 -0.001 NA 0.000 NA -0.003 4.1e-01 NA 3.4e-01 NA 7.8e-01
2 GTEx Adrenal Gland 0.2530 0.0866 3.7e-03 0.098 NA 0.007 NA 0.027 2.3e-04 NA 1.7e-01 NA 3.6e-02
3 GTEx Cells EBV-transformed lymphocytes 0.3850 0.0980 4.6e-04 0.070 NA 0.101 NA 0.095 2.6e-03 NA 3.5e-04 NA 5.4e-04
4 GTEx Colon Sigmoid 0.4210 0.1010 1.5e-04 0.001 NA 0.124 NA 0.100 2.9e-01 NA 3.9e-05 NA 2.2e-04
5 GTEx Esophagus Muscularis 0.2790 0.0610 4.5e-06 0.052 NA 0.152 NA 0.138 4.2e-04 NA 1.6e-09 NA 9.6e-09
6 GTEx Nerve Tibial 0.2140 0.0606 1.1e-04 0.075 NA 0.050 NA 0.083 5.5e-06 NA 2.0e-04 NA 1.7e-06
7 GTEx Skin Sun Exposed Lower leg 0.1680 0.0600 4.3e-03 0.000 NA 0.001 NA -0.001 3.2e-01 NA 2.7e-01 NA 4.5e-01
8 GTEx Testis 0.2530 0.0770 2.3e-03 0.035 NA 0.025 NA 0.041 1.1e-02 NA 2.7e-02 NA 6.4e-03
9 TCGA Head and Neck Squamous Cell Carcinoma 0.0807 0.0306 1.9e-05 0.015 0.052 0.036 NA 0.033 7.5e-03 1.7e-06 5.8e-05 NA 1.2e-04
10 TCGA Prostate Adenocarcinoma 0.0597 0.0343 5.9e-03 -0.002 0.010 0.013 NA 0.005 6.5e-01 3.0e-02 1.4e-02 NA 8.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.5 0.7 1.8 0.0 0.5 0.8 0.4 1.2 1.2 0.3 0.6 1.1 1.3
Bipolar Disorder or Schizophrenia 0.2 0.6 2.3 0.0 -1.1 0.6 0.4 -0.0 0.0 -0.5 1.5 0.8 -1.0
Depressed Affect (Nagel 2018) 0.3 0.7 3.1 0.0 -0.7 -0.6 0.3 0.4 -0.7 -1.0 0.0 -1.1 -1.8
Depression (Nagel 2018) 0.7 1.1 7.5 0.0 -0.2 -0.9 -0.6 0.2 -0.8 -0.1 0.6 -1.1 -2.7
Intelligence (Savage-Jansen 2018) 0.2 0.5 2.7 0.0 -0.2 0.3 -0.7 -1.6 -0.8 -0.3 -0.9 -0.6 0.3
Neuroticism (Nagel 2018) 0.4 0.8 3.8 0.0 -0.9 -0.5 -0.1 -0.3 -1.1 -0.8 -0.4 -1.1 -2.0
Schizophrenia (2018) 0.6 1.3 5.7 0.0 -1.7 0.2 0.6 -1.0 -0.9 -0.8 1.1 0.1 -2.4
Schizophrenia vs Biploar Disorder 2.7 3.6 8.6 0.0 -2.6 -1.6 -1.0 -2.9 -2.9 -1.5 0.0 -1.9 -1.7
Worry (Nagel 2018) 0.2 0.5 2.6 0.0 -0.9 0.6 -0.2 -0.3 -0.9 -0.5 -0.3 0.0 -1.6
Alzheimer’s Disease (in mother) 1.0 1.2 4.7 0.0 0.5 -0.6 -2.2 0.2 -0.5 -1.3 -1.7 -0.0 1.4
Alzheimer’s Disease (in father) 0.6 0.7 3.2 0.0 1.8 -0.8 0.5 -0.2 1.1 0.3 -0.6 0.3 1.0
Alzheimer’s Disease (including proxy) 1.1 1.6 4.7 0.0 1.5 -1.1 -1.7 -0.4 0.2 -0.6 -2.2 -0.0 2.0
Crohns Disease (2017) 0.5 1.2 4.1 0.0 -0.5 1.7 -0.1 -1.0 -0.5 0.1 0.2 2.0 1.7
Irritable Bowel Disease (IBD) 0.4 0.9 2.9 0.0 -0.9 1.7 -1.2 -0.7 -0.5 -0.4 0.6 1.3 0.7
Ulcerative Colitis (UC) 0.3 0.5 1.6 0.0 -0.9 0.8 -0.7 0.3 -0.3 -0.8 0.9 -0.4 -1.2
Major Depression (MDD) 0.2 0.2 0.5 0.0 -0.7 -0.7 -0.6 0.1 -0.6 -0.2 0.0 0.1 0.5
Reaction Time 0.3 0.6 2.2 0.0 0.9 -1.3 -1.5 -0.3 0.3 -0.7 -0.1 0.2 -0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.7 3.6 0.0 0.0 0.8 1.9 -0.8 -0.7 -0.1 -1.1 -0.4 0.9
Breast Cancer 0.4 1.0 2.2 0.0 -0.1 -1.1 1.5 -1.2 -0.6 -0.7 -1.4 -1.0 1.2
Ovarian Cancer 0.9 1.2 3.3 0.0 -1.2 -1.1 -0.4 -1.2 -1.8 -0.3 -1.2 -1.6 -0.3
Prostate Cancer 0.6 0.9 4.3 0.0 -1.1 -1.0 -0.5 -2.1 -1.0 -0.1 -0.6 -0.7 -0.7
Age at First Birth 0.2 0.3 1.1 0.0 -0.3 0.1 -1.0 -0.1 0.4 0.4 1.0 0.3 -0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 1.0 0.0 -0.4 0.6 0.6 0.0 -0.9 0.2 -1.0 0.3 0.1
Coronary Artery Disease (CAD) 0.5 0.6 5.1 0.0 -0.9 2.2 -0.1 -0.7 -0.2 -0.2 0.0 0.0 0.0
Crohns Disease (2012) 0.6 1.0 3.1 0.0 -1.1 1.5 0.2 -1.5 -1.0 0.7 0.0 1.8 0.1
Mean Putamen Volume 0.8 0.9 3.3 0.0 0.7 0.6 0.5 1.5 0.9 0.8 1.8 0.7 -0.5
Fasting Glucose 0.8 0.9 4.0 0.0 -1.3 1.6 0.3 0.5 0.3 0.3 2.0 0.6 0.2
HbA1C 0.3 0.3 1.3 0.0 -0.7 0.1 0.1 -0.5 -0.4 1.0 -0.2 -0.2 -1.1
HDL Cholesterol 0.6 1.0 4.2 0.0 1.1 -0.1 2.0 0.3 1.2 -0.1 0.5 0.5 -1.7
LDL Cholesterol 20.6 32.5 249.6 0.0 2.3 2.3 -2.5 -1.0 -0.0 2.4 -1.6 7.0 15.8
Lupus 0.4 0.6 3.3 0.0 -0.7 -0.5 -0.7 0.2 0.1 0.6 0.6 -0.5 -1.8
Neuroticism (2016) 1.1 1.5 4.7 0.0 -1.0 -2.2 -1.3 -1.2 -0.8 -0.2 0.4 -1.5 -1.9
Primary Biliary Cirrhosis 0.7 1.0 6.6 0.0 0.1 0.1 -2.6 -0.5 0.5 -0.4 0.6 1.3 0.4
Rheumatoid Arthritis 0.3 0.4 2.2 0.0 0.1 -0.6 0.1 0.8 0.4 -0.4 0.1 0.0 -1.5
Schizophrenia (2014) 0.2 0.5 1.7 0.0 -1.2 0.1 0.2 -1.3 -1.1 -0.6 -0.2 -0.4 -0.3
Triglycerides 0.1 0.2 0.7 0.0 0.4 0.2 -0.6 0.3 0.1 -0.4 0.2 0.1 0.8
Type 2 Diabetes (T2D) (2012) 0.8 0.9 3.2 0.0 -1.1 -0.4 -0.9 -1.8 -0.6 0.1 0.0 -1.2 -1.2
Ulcerative Colitis 0.2 0.3 1.2 0.0 -0.9 1.1 0.7 0.1 0.1 0.2 0.5 0.2 -0.5
Blood Eosinophil Count 0.5 4.0 8.5 0.0 2.6 2.8 2.9 2.3 2.3 0.7 -0.0 1.6 1.6
Blood Platelet Count 0.4 4.9 14.4 0.0 2.9 2.0 3.8 3.5 1.9 1.5 -0.4 1.3 1.3
Blood Red Count 0.2 1.5 6.6 0.0 -1.0 -0.5 0.6 0.6 -0.1 1.9 0.2 -1.8 -2.6
Blood White Count 1.1 7.9 21.4 0.0 3.9 2.3 2.5 2.5 4.6 4.4 1.6 1.5 0.7
Heel T-Score 0.4 3.2 12.0 0.0 1.8 1.8 2.2 3.5 1.8 0.3 1.8 1.1 -1.0
BMI 0.2 0.9 3.3 0.0 -1.1 -0.2 1.8 0.5 -1.8 0.2 -0.8 -0.4 0.0
Height 0.4 8.0 29.6 0.0 -1.7 0.9 -5.1 -0.5 0.4 -0.1 3.8 -2.5 -5.4
Waist Hip Ratio (WHR) 0.1 0.6 2.7 0.0 -0.8 0.0 -0.6 -0.5 -0.1 -0.5 -0.8 -1.6 -1.0
Systolic Blood Pressure 0.2 0.8 2.2 0.0 0.8 -0.4 -0.0 -0.6 1.5 1.3 0.9 0.0 1.5
Smoking Status 0.3 0.6 1.7 0.0 1.0 -0.8 -0.9 0.4 -0.2 -0.4 -1.1 -1.3 0.9
Allergy or Eczema 0.3 0.8 5.6 0.0 0.6 0.3 0.9 0.0 0.3 -0.6 -0.6 0.5 2.4
Cardiovascular Disease 1.8 6.1 39.7 0.0 1.6 0.4 -0.7 -0.1 1.2 2.4 0.8 3.1 6.3
Hypothyroidism (self reported) 0.4 0.8 2.4 0.0 0.8 0.7 -0.3 0.8 1.1 -1.5 0.8 1.1 0.9
Respiratory disease 0.9 1.9 4.7 0.0 0.9 2.2 1.8 1.8 1.4 0.3 0.1 2.1 0.9
Type 2 Diabetes (T2D) (2018) 2.3 4.2 10.0 0.0 1.9 1.7 1.8 3.2 2.7 2.7 2.2 1.8 -0.1
Lung FEV1/FVC ratio 0.3 1.6 6.3 0.0 -1.5 -1.9 -1.0 -0.1 -1.2 0.5 1.0 -0.3 -2.5
Lung FVC 0.4 2.0 6.5 0.0 1.4 0.8 2.4 2.5 1.2 1.3 1.0 0.9 0.6
Neuroticism 0.8 1.9 4.6 0.0 -1.0 -1.4 -0.5 -0.9 -2.0 -1.3 -2.1 -1.7 -1.0
Chronotype (morning person) 0.2 0.6 1.7 0.0 0.2 0.0 -0.3 0.9 0.7 0.8 1.0 1.3 -0.8
Hair Pigment 0.1 3.5 9.1 0.0 1.9 0.6 -1.4 1.7 2.2 0.6 1.6 3.0 3.0
Tanning 0.1 0.7 3.0 0.0 -0.4 1.2 -0.5 -0.5 0.2 0.8 0.9 1.7 0.8
Hand grip strength (left) 0.2 0.5 2.2 0.0 0.7 -0.1 -1.5 0.9 0.6 -0.1 0.2 -1.1 -0.2
Number of treatments/medications taken 2.2 3.9 9.5 0.0 1.2 2.5 -1.4 1.9 2.1 1.6 3.1 2.6 1.7
Average weekly spirits intake 0.5 0.6 2.5 0.0 -1.4 0.1 -0.3 -0.1 -1.1 -0.1 1.6 -0.6 0.5
Sensitivity / hurt feelings 0.6 1.0 4.4 0.0 -0.3 -2.1 -0.6 -0.8 -1.0 -0.3 -1.1 -1.5 -0.7
Frequency of depressed mood in last 2 weeks 0.7 0.9 4.5 0.0 -0.2 -0.5 -0.4 0.3 -1.3 -0.6 -0.8 -1.3 -2.1
Hearing difficulty/problems: Yes 0.2 0.4 1.4 0.0 -0.2 -0.5 0.2 0.2 -0.7 0.5 -1.0 -1.2 -0.1
Relative age of first facial hair 1.3 2.6 5.9 0.0 -1.2 -2.4 -0.4 -2.4 -1.7 -1.4 -2.4 -1.6 0.5
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 4.7 0.0 0.0 1.6 -2.2 0.8 0.2 -0.2 1.7 1.8 0.5
Ever used hormone-replacement therapy (HRT) 0.6 0.7 3.1 0.0 -0.1 -1.3 -1.8 -1.2 -0.3 0.2 -0.6 -0.2 0.7
Ever had hysterectomy (womb removed) 0.7 0.8 3.7 0.0 -1.0 0.5 0.9 0.6 -0.1 -1.0 0.8 -0.5 -1.9
Systolic blood pressure, automated reading 0.3 0.9 2.2 0.0 1.1 0.4 0.1 0.2 1.4 1.0 1.5 0.7 1.2
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.5 0.0 0.5 0.3 0.5 0.7 0.1 0.1 -0.2 0.7 -0.2
Angina 3.0 3.9 22.8 0.0 1.2 1.7 -0.1 0.9 1.2 1.6 0.6 2.6 4.8
Medication for hormone replacement therapy 0.5 0.5 1.3 0.0 0.7 0.6 1.0 0.7 0.6 0.6 -0.4 1.1 0.8
Vitamin and mineral supplements 0.4 0.6 3.2 0.0 0.5 0.4 0.5 0.3 -0.1 0.0 -1.1 0.8 1.8
Supplements: Zinc 0.6 0.6 1.6 0.0 0.1 -1.2 0.0 -0.5 -0.7 -1.0 -1.3 -1.1 0.2
Medication: Co-codamol 0.7 0.8 3.1 0.0 -0.1 0.5 -0.8 1.0 0.1 -1.1 1.1 0.5 -1.8
Medication: Metformin 3.0 4.3 9.1 0.0 1.9 2.0 1.1 3.0 2.9 2.8 2.0 1.7 1.1
Diabetes (father) 0.4 0.5 3.3 0.0 -1.0 -0.1 0.6 0.1 -0.4 0.9 -0.0 0.1 -1.8
Diabetes (mother) 0.4 0.5 2.9 0.0 -0.0 -0.9 0.0 1.0 0.2 0.2 0.3 -0.7 -1.7
Severe depression (siblings) 0.2 0.2 0.8 0.0 0.0 -0.9 0.1 -0.3 -0.1 -0.5 -0.6 -0.7 -0.2
Pack years adult smoking proportion 0.4 0.6 2.1 0.0 -1.1 -0.7 -0.2 -0.8 -1.5 0.1 -0.5 -1.2 0.1
Impedance of leg (right) 0.2 1.2 4.2 0.0 -0.5 1.6 0.8 0.2 -0.3 -2.0 -1.2 0.0 1.6
Leg fat-free mass (left) 0.5 2.5 12.5 0.0 -0.5 -1.1 -1.7 0.6 -0.2 1.2 1.9 -1.6 -3.5
Trunk fat percentage 0.1 0.4 1.2 0.0 -0.5 0.6 0.6 1.1 -0.4 0.5 1.1 0.4 -0.2
Hand grip strength (right) 0.3 0.7 3.2 0.0 0.5 -0.7 -1.8 0.4 0.0 -0.5 -0.5 -1.4 -0.5
Townsend deprivation index at recruitment 0.7 1.0 6.9 0.0 0.2 0.7 -2.6 0.6 0.2 0.9 0.4 0.7 -0.9
Current tobacco smoking 0.8 1.3 5.7 0.0 2.4 0.2 0.4 1.6 1.4 0.2 -0.0 0.2 1.5
Average weekly fortified wine intake 0.5 0.6 2.1 0.0 -0.8 0.7 -1.4 -1.2 0.2 0.0 -0.0 0.0 0.9
Maternal smoking around birth 0.2 0.3 1.0 0.0 -0.7 -1.0 0.0 -0.5 0.0 0.6 0.1 -0.6 -0.7
Fed-up feelings 0.2 0.4 2.2 0.0 -0.0 -0.0 0.6 0.7 -0.3 -0.1 0.8 -0.3 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 4.6 0.0 -0.8 -1.2 -1.0 -1.0 -1.9 -1.6 -1.2 -1.9 -2.1
Relative age voice broke 3.1 4.7 14.9 0.0 -2.2 -2.5 1.0 -3.9 -3.0 -1.2 -2.6 -1.4 -0.6
Taking other prescription medications 1.4 2.1 4.1 0.0 0.9 2.0 -0.3 1.6 1.9 1.1 2.0 2.0 0.8
Age when periods started (menarche) 0.2 0.6 1.7 0.0 -0.5 -0.8 0.7 -0.8 -0.5 0.2 -1.3 -1.1 -0.8
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 3.3 0.0 -0.5 1.1 1.8 0.2 0.2 -0.2 0.1 0.2 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 7.3 0.0 1.2 1.1 2.6 2.7 1.1 0.0 0.3 -0.4 0.7
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.5 0.0 -0.8 -1.1 -0.1 -1.1 -1.6 -1.4 -1.6 -1.4 -0.6
Qualifications: CSEs or equivalent 0.9 1.2 5.0 0.0 -1.0 -0.7 0.3 -1.0 -1.2 -0.2 -1.2 -1.2 -2.2
Serious illness, injury or assault to yourself 0.4 0.5 1.2 0.0 0.6 -0.0 -1.1 -0.0 1.0 1.1 0.9 0.5 0.5
High blood pressure 0.6 1.6 4.4 0.0 1.5 -0.6 -0.7 0.6 1.5 2.1 1.5 0.9 1.6
Hayfever, allergic rhinitis or eczema 0.6 1.4 3.7 0.0 1.3 1.7 1.1 0.8 1.0 -0.3 -0.7 1.5 1.9
Multivitamins +/- minerals 0.5 0.7 3.8 0.0 -0.0 -0.7 -0.5 0.3 -0.3 -0.5 0.7 -1.0 -1.9
Stomach or abdominal pain in last month 0.3 0.3 1.9 0.0 0.4 -0.0 1.4 0.6 -0.2 0.5 -0.1 0.1 -0.8
Supplements: Glucosamine 1.1 1.4 5.1 0.0 0.9 -0.1 0.9 1.2 1.5 -0.5 2.3 -0.1 -1.9
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 0.0 -0.2 0.7 0.2 0.3 -0.3 0.7 0.2 0.8 -0.8
Medication: Atenolol 0.7 0.9 3.1 0.0 -1.4 -0.1 -1.4 -1.8 -0.7 0.8 1.0 0.3 0.1
Medication: Levothyroxine sodium 0.2 0.3 1.7 0.0 0.4 0.2 -0.1 -0.1 0.3 -1.3 0.5 0.8 0.6
Sitting height 0.6 4.5 15.8 0.0 -1.2 -0.0 -3.9 -1.0 -0.5 1.3 2.1 -2.1 -4.0
Chronic bronchitis/emphysema (father) 1.3 1.5 3.8 0.0 0.2 -1.9 -1.8 -0.3 0.3 0.2 1.1 -2.0 -1.8
High blood pressure (mother) 0.7 0.9 3.1 0.0 -1.2 -1.0 -0.2 -1.4 -1.8 -0.8 0.0 -0.8 -0.3
Body mass index (BMI) 0.1 0.3 1.3 0.0 -0.1 -0.4 1.1 1.1 -0.8 0.3 0.0 0.1 0.0
Impedance of leg (left) 0.3 1.5 4.0 0.0 -0.6 1.7 0.6 -0.3 -0.7 -2.0 -1.7 -0.1 2.0
Leg predicted mass (left) 0.5 2.5 12.5 0.0 -0.5 -1.2 -1.7 0.6 -0.3 1.2 1.8 -1.6 -3.5
Trunk fat mass 0.1 0.6 1.7 0.0 -0.7 0.2 -0.1 1.0 -0.7 0.6 1.3 -0.4 -1.2
Waist circumference 0.1 0.2 0.9 0.0 -0.5 0.1 0.1 0.8 -0.5 0.1 0.6 -0.2 -0.9
Number of incorrect matches in round 0.5 0.8 4.4 0.0 -0.3 1.1 -0.9 0.4 0.1 -0.1 0.8 0.5 -2.1
Past tobacco smoking 0.5 0.9 2.3 0.0 1.1 0.6 0.3 1.1 1.5 0.5 0.8 1.5 0.8
Alcohol usually taken with meals 0.5 0.8 4.6 0.0 -0.6 0.7 -0.8 -1.2 -0.2 -0.0 0.8 2.1 0.2
Nervous feelings 1.3 2.5 9.5 0.0 -1.5 -0.5 -0.9 -3.1 -2.5 -1.6 -1.4 -0.9 -0.5
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 5.9 0.0 -0.6 -1.2 -1.1 -0.2 -1.5 -2.4 -1.6 -1.7 -0.7
Hearing difficulty/problems with background noise 0.3 0.5 1.4 0.0 -0.1 -0.2 -0.5 -0.6 -1.2 -1.2 -0.9 -0.4 0.8
Hair/balding pattern: Pattern 2 0.7 0.8 4.2 0.0 0.0 -1.7 -2.0 0.4 -0.3 -0.1 -0.8 -0.7 0.3
Had menopause 0.3 0.4 1.6 0.0 0.5 -0.2 1.2 0.4 0.1 -0.0 0.1 0.5 1.3
Had other major operations 0.4 0.5 2.6 0.0 0.6 0.2 0.3 0.7 0.8 1.6 0.8 -0.1 -0.6
Forced vital capacity (FVC) 0.1 0.6 3.2 0.0 0.2 0.2 -0.0 0.8 0.2 0.7 0.2 -1.0 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 7.2 0.0 1.3 1.0 2.6 2.7 1.2 0.3 0.8 -0.1 0.4
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 5.2 0.0 -0.6 -1.0 -0.8 -0.5 -0.5 -0.8 0.8 -0.4 -2.3
Qualifications: None of the above 0.2 0.4 1.6 0.0 0.1 0.3 0.1 -0.5 0.6 -1.1 1.3 0.0 -0.3
Financial difficulties in last 2 years 0.3 0.4 1.6 0.0 0.6 -1.3 0.2 0.9 0.4 -0.1 0.3 -1.0 -0.4
Mouth/teeth dental problems 1.0 1.5 6.7 0.0 0.9 0.8 0.8 1.3 1.4 2.6 -0.9 1.1 1.0
Heart attack 2.2 2.8 20.6 0.0 0.3 0.6 0.4 -0.2 0.3 1.7 -1.0 1.5 4.5
Allergy 1.8 4.1 11.1 0.0 -2.2 -3.3 -1.6 -2.0 -2.3 -0.6 0.2 -2.7 -2.3
Pain all over the body in last month 0.9 0.9 3.0 0.0 -0.9 -0.8 0.5 -1.1 -1.0 -1.7 -1.3 -0.5 -0.5
Diabetes (self-reported) 2.9 4.5 12.0 0.0 1.9 2.0 1.6 3.0 2.6 3.5 1.7 2.0 0.5
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.1 0.0 1.0 0.5 0.5 0.6 0.7 -0.3 -0.4 0.7 -0.2
Medication: Ramipril 1.0 1.2 4.0 0.0 1.4 0.5 -0.8 1.1 2.0 0.7 0.4 0.5 1.9
Medication: Simvastatin 5.8 8.5 52.9 0.0 0.7 2.7 -2.4 -0.5 0.9 1.1 1.2 3.8 7.3
Fluid intelligence score 1.1 2.3 8.1 0.0 1.4 1.1 2.5 -0.5 0.7 0.8 -1.5 1.2 2.8
Illnesses of siblings 1.0 1.5 4.0 0.0 -1.7 -0.4 -0.2 -0.8 -0.8 -1.6 -0.4 -1.9 -2.0
Neuroticism score 1.2 2.5 4.2 0.0 -1.0 -1.9 -1.4 -1.6 -2.0 -1.4 -1.8 -2.1 -1.3
Weight 0.2 1.1 5.5 0.0 -0.6 -0.2 -0.8 1.0 -0.7 0.6 1.3 -0.9 -2.4
Impedance of arm (right) 0.1 0.2 1.2 0.0 0.3 0.6 0.3 -0.1 1.1 0.2 0.2 0.7 0.3
Arm fat percentage (right) 0.1 0.5 2.3 0.0 0.3 -0.1 1.5 1.4 -0.1 0.6 0.4 0.4 0.2
Trunk fat-free mass 0.4 2.6 13.6 0.0 -0.3 -0.6 -1.9 0.5 -0.3 0.7 1.7 -2.0 -3.7
Hip circumference 0.1 0.3 0.7 0.0 -0.6 -0.1 0.2 0.8 -0.8 0.1 0.9 0.1 -0.7
Time employed in main current job 0.4 0.4 2.4 0.0 -0.7 0.6 0.3 -0.9 -0.5 -1.6 -0.1 0.0 0.2
Alcohol intake versus 10 years previously 0.5 0.7 2.5 0.0 0.1 -0.9 1.6 0.8 0.1 0.1 -0.4 -1.3 -1.1
Father’s age at death 0.8 1.1 5.4 0.0 0.0 -0.3 -0.6 1.2 1.0 -0.1 1.5 0.2 -2.3
Worrier / anxious feelings 0.2 0.3 1.0 0.0 0.4 1.0 -1.0 0.8 0.2 0.0 -0.4 0.7 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 1.0 0.0 0.2 -0.0 -0.2 0.4 -0.3 0.7 0.3 -0.2 -1.0
Falls in the last year 3.0 4.1 10.0 0.0 -2.8 -3.2 -0.2 -2.5 -2.6 -1.7 -0.3 -2.2 -1.5
Hair/balding pattern: Pattern 3 0.7 1.0 4.9 0.0 -0.0 1.0 -0.1 -0.1 0.9 2.2 1.2 1.2 0.6
Number of live births 0.5 0.7 2.8 0.0 0.1 1.1 -0.4 0.5 0.1 0.3 -0.0 1.4 1.7
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 4.3 0.0 -0.8 -0.7 -0.0 0.6 -0.6 0.2 -0.1 -1.8 -2.1
Pulse rate 2.2 3.7 9.2 0.0 2.5 2.0 -0.2 1.7 3.0 2.4 1.9 2.2 0.3
Happiness 0.6 0.8 4.8 0.0 -0.9 -0.4 -0.3 -0.9 -0.2 -0.3 0.4 -0.8 -2.2
Noisy workplace 0.7 0.8 2.2 0.0 -0.7 -1.0 0.1 -0.9 -1.1 -0.8 -1.2 -1.5 0.6
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.5 0.0 0.1 0.0 -1.2 -0.4 -0.2 0.6 -0.5 -0.1 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 3.2 0.0 -1.1 -0.9 0.8 -1.2 -1.8 -1.2 -1.2 -0.6 -0.6
Mouth/teeth dental problems: Dentures 0.9 1.5 3.7 0.0 -1.4 -0.1 -1.4 -1.3 -1.8 -1.9 1.0 -0.6 -1.0
Asthma 2.0 3.9 9.3 0.0 2.1 3.0 2.0 2.0 2.5 1.5 0.7 2.7 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 4.6 0.0 -0.3 -1.1 -0.5 0.0 -0.6 -0.6 0.7 -0.5 -2.1
Medication: Cholesterol lowering 7.0 10.8 66.8 0.0 0.5 3.2 -2.4 0.1 1.2 0.9 2.2 4.2 8.2
Depression (self-reported) 0.5 0.5 1.5 0.0 0.0 0.8 0.7 1.2 0.3 -1.2 0.3 -1.1 -0.1
Medication: Lansoprazole 0.3 0.3 1.1 0.0 -1.0 -1.0 0.5 -0.3 -0.7 -0.2 0.2 -0.0 -0.3
Prospective memory result 1.0 1.3 6.3 0.0 -1.6 -1.0 -2.5 -1.2 -0.8 -0.2 0.6 -0.8 -0.0
Lung cancer (father) 0.1 0.2 0.5 0.0 0.1 -0.3 -0.3 -0.7 0.1 -0.5 0.5 -0.5 -0.4
Illnesses of mother 0.7 0.9 3.0 0.0 0.3 1.7 0.3 0.8 1.1 1.3 0.4 1.3 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.3 0.0 -1.2 -0.5 -0.4 0.7 -0.6 0.6 0.6 -1.6 -1.8
Pulse wave Arterial Stiffness index 0.5 0.6 1.7 0.0 -0.4 -1.1 -0.3 -1.1 -0.3 -0.8 0.6 -0.8 -1.3
Impedance of arm (left) 0.1 0.3 1.0 0.0 0.4 0.4 -0.2 -0.4 1.0 0.1 0.0 0.9 0.9
Arm fat mass (right) 0.1 0.4 1.4 0.0 0.0 -0.4 0.8 1.2 -0.5 0.6 0.7 -0.4 -0.8
Trunk predicted mass 0.5 2.6 14.0 0.0 -0.3 -0.6 -1.9 0.6 -0.3 0.7 1.8 -2.0 -3.7
Standing height 0.6 5.8 27.9 0.0 -1.2 0.3 -3.9 -0.3 0.0 0.4 2.7 -2.4 -5.3
Length of working week for main job 1.5 1.6 3.6 0.0 1.1 -1.6 1.2 -0.9 -0.2 -1.3 -1.7 -1.9 1.5
Exposure to tobacco smoke at home 0.2 0.2 1.2 0.0 -0.3 0.1 -0.7 0.5 0.2 1.1 0.6 -0.0 -0.2
Breastfed as a baby 0.9 1.1 4.5 0.0 -0.4 -0.3 -1.8 -2.1 -0.5 -1.3 -0.3 -1.0 0.2
Tense / ‘highly strung’ 0.8 1.3 3.3 0.0 -0.4 -1.8 -0.6 -0.9 -1.1 -0.8 -1.4 -1.4 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 3.3 0.0 -0.5 -1.2 -1.0 -1.1 -1.4 -1.1 -1.1 -1.8 -1.5
Hair/balding pattern: Pattern 4 0.4 1.1 2.2 0.0 1.4 1.5 1.1 -0.1 0.9 0.9 -0.7 1.1 1.4
Birth weight of first child 0.4 0.7 3.4 0.0 -0.7 -0.6 -0.2 -0.8 -0.8 -1.0 0.2 -0.9 -1.8
Peak expiratory flow (PEF) 1.1 2.6 11.0 0.0 -2.1 -1.5 -1.4 -0.6 -1.3 -0.5 -0.6 -3.3 -2.0
Pulse wave reflection index 1.2 1.5 5.9 0.0 -0.6 -2.4 0.0 -0.7 -1.5 -1.7 -1.0 -1.3 -0.7
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.6 0.0 0.3 -1.0 -0.2 0.6 -0.5 0.5 -1.3 -0.7 0.2
Loud music exposure frequency 2.0 2.2 5.7 0.0 -1.1 -2.2 -1.0 -1.4 -1.3 -1.6 -1.5 -2.4 -0.0
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 3.0 0.0 0.5 0.5 0.1 1.7 0.6 0.4 -0.2 0.7 0.8
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.8 0.0 -0.2 -1.7 0.9 -1.2 -0.4 -1.6 -0.8 -1.7 0.3
Blood clot in the leg (DVT) 1.2 1.6 4.9 0.0 1.1 2.2 -0.9 1.1 1.5 0.3 0.1 1.6 1.6
Medication: Paracetamol 0.4 0.6 3.9 0.0 1.2 -0.5 0.3 2.0 0.3 0.0 -0.1 -0.4 -0.8
Headache pain in last month 0.9 1.5 4.3 0.0 1.0 1.8 0.3 2.1 1.5 0.3 1.2 1.7 -0.5
Medication for cholesterol, blood pressure or diabetes 3.0 5.0 24.0 0.0 -0.4 -2.7 1.4 -0.7 -1.4 -0.8 -2.1 -2.9 -4.9
Glaucoma (self-reported) 1.6 1.9 6.7 0.0 -1.5 1.6 0.2 0.3 0.4 0.7 2.6 1.2 -2.3
Gout (self-reported) 1.2 1.6 4.4 0.0 1.7 0.9 1.3 2.1 1.2 1.5 0.1 1.5 0.7
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 2.9 0.0 1.2 0.9 -0.4 0.4 1.0 -1.7 0.3 1.4 1.6
Medication: Amlodipine 0.7 0.9 3.0 0.0 1.1 0.1 -0.3 -0.3 1.4 1.2 1.7 0.9 -0.8
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.8 0.0 0.7 1.3 -0.6 0.4 1.0 0.2 1.0 1.4 -1.1
Birth weight 0.6 1.3 6.2 0.0 -0.8 0.1 -1.3 -0.2 -0.3 -0.1 1.6 -1.2 -2.5
Chronic bronchitis/emphysema (mother) 0.9 1.0 2.1 0.0 -1.2 -1.4 0.0 -1.4 -1.0 -1.1 -0.1 -1.0 -1.2
High blood pressure (siblings) 1.8 2.6 6.0 0.0 2.4 1.4 1.1 1.4 1.8 1.5 1.3 2.5 1.4
Forced vital capacity (FVC), Best measure 0.2 0.8 3.2 0.0 -0.2 0.4 -0.3 1.1 0.2 0.9 1.2 -0.9 -1.8
Body fat percentage 0.1 0.3 1.1 0.0 -0.5 0.3 0.9 1.1 -0.8 0.2 0.5 0.3 0.2
Leg fat percentage (right) 0.2 0.6 1.3 0.0 -0.5 0.4 1.1 1.1 -1.1 -1.0 -0.3 0.1 0.8
Arm fat-free mass (right) 0.4 1.8 9.0 0.0 -0.7 -0.2 -1.5 0.8 -0.7 0.5 1.5 -1.6 -3.0
Exposure to tobacco smoke outside home 0.1 0.2 0.7 0.0 0.1 0.6 0.4 -0.4 -0.2 0.8 -0.5 -0.4 0.2
Comparative body size at age 10 0.3 0.8 2.6 0.0 -0.7 -1.4 1.1 -0.2 -0.7 -0.4 -0.3 -1.6 -0.8
Number of full brothers 2.7 3.4 6.6 0.0 -1.6 -2.2 -0.6 -1.8 -2.5 -2.1 -2.2 -2.6 -0.4
Worry too long after embarrassment 0.5 0.9 2.7 0.0 -0.7 -1.3 -0.7 -1.6 -1.1 -0.4 -0.6 -1.2 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 2.5 0.0 1.6 0.4 -0.7 1.5 1.5 0.4 0.8 0.2 -1.0
Wheeze or whistling in the chest in last year 0.7 1.2 3.2 0.0 1.8 1.0 1.6 1.4 1.1 -0.4 -1.0 0.8 0.8
Number of children fathered 0.3 0.3 1.0 0.0 0.5 -0.6 -0.3 1.0 0.2 -0.1 -0.8 -0.1 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.1 0.0 0.3 -0.6 0.1 -0.6 0.2 0.4 0.4 0.8 -1.1
Age at first live birth 0.4 0.8 1.7 0.0 -0.0 -1.3 -1.1 -1.1 0.4 1.3 0.7 -0.5 -1.0
Pulse wave peak to peak time 0.3 0.4 1.6 0.0 0.2 1.2 0.2 1.0 0.2 0.6 -0.4 0.4 0.8
Health satisfaction 0.2 0.2 0.7 0.0 0.4 0.2 0.1 0.4 0.4 0.5 0.8 0.8 -0.4
Shortness of breath walking on level ground 2.1 2.5 5.7 0.0 1.8 1.4 0.9 2.4 2.1 0.7 1.9 2.1 -0.1
Qualifications: College or University degree 0.3 0.9 3.3 0.0 -1.1 -0.4 -1.4 -1.8 -0.4 1.2 0.0 0.3 -1.0
Eye problems/disorders: None of the above 2.6 3.0 5.7 0.0 -1.7 -2.3 0.1 -2.4 -2.2 -1.4 -1.7 -2.0 -1.5
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.2 0.0 -0.5 -1.8 0.5 -0.8 -1.4 -1.6 -0.2 -1.1 -1.3
Emphysema/chronic bronchitis 0.5 0.6 2.2 0.0 -0.3 1.0 -1.2 0.1 0.1 -1.5 0.2 0.3 1.1
Medication for pain relief, constipation, heartburn 0.8 1.4 4.9 0.0 -0.9 -1.2 1.0 -2.2 -0.8 -0.0 -1.1 -1.4 -1.4
Neck or shoulder pain in last month 0.1 0.1 0.6 0.0 -0.5 0.3 0.3 0.3 -0.3 -0.8 0.2 0.3 -0.0
Medication: Blood pressure 0.9 1.7 3.1 0.0 0.9 1.1 -0.9 0.7 1.7 1.8 1.5 1.6 1.6
Angina (self-reported) 2.4 3.2 18.5 0.0 0.9 1.5 -0.4 0.8 1.0 1.2 0.8 2.5 4.3
Migraine (self-reported) 0.9 1.1 4.4 0.0 -2.1 0.7 -0.1 -0.2 -1.4 -0.9 -1.0 -1.3 -0.6
Medication: Ibuprofen 0.6 0.7 2.5 0.0 -0.4 -1.2 -1.1 -0.3 -0.8 -0.5 0.4 -0.7 -1.6
Medication: Allopurinol 1.0 1.3 4.7 0.0 0.8 1.3 0.9 1.6 1.1 0.4 1.1 2.2 -0.0
Medication: Omeprazole 1.0 1.3 3.5 0.0 0.7 1.3 0.4 1.9 1.0 -0.7 0.6 1.7 1.4
Medication: Seretide 50 evohaler 0.5 0.6 2.0 0.0 1.4 -0.2 0.5 0.4 1.1 0.7 0.3 1.1 -0.8
Mean time to correctly identify matches 0.4 0.7 1.9 0.0 1.4 -0.3 -0.6 0.6 1.2 0.1 1.0 1.2 -0.8
Heart disease (mother) 0.6 0.7 3.8 0.0 0.2 0.1 -1.0 0.4 0.5 -0.5 1.1 0.5 1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 4.4 0.0 -0.7 -1.1 -0.5 -2.1 -1.0 -1.3 -1.3 -1.2 -0.7
Whole body fat mass 0.1 0.5 1.2 0.0 -0.5 0.1 0.2 1.1 -0.7 0.7 1.1 -0.3 -1.0
Leg fat mass (right) 0.1 0.4 1.6 0.0 -0.5 -0.1 0.5 1.3 -0.9 -0.2 0.4 -0.5 -0.7
Arm predicted mass (right) 0.4 2.0 8.8 0.0 -0.7 -0.5 -1.9 0.5 -0.7 0.5 1.6 -1.8 -3.0
Pulse rate, automated reading 1.1 3.6 7.0 0.0 1.2 1.9 1.4 2.3 2.1 2.4 2.2 1.5 -2.6
Alcohol intake frequency. 0.3 0.6 2.8 0.0 -0.8 -0.7 -0.3 -0.5 -0.8 -0.6 0.6 -0.7 -1.7
Comparative height size at age 10 1.0 5.4 23.7 0.0 -1.8 1.1 -3.2 -0.5 -0.1 0.8 3.5 -1.3 -4.9
Number of full sisters 0.5 0.6 2.9 0.0 0.5 -0.2 1.7 1.5 0.5 -0.1 0.1 -0.1 0.5
Suffer from ‘nerves’ 0.8 1.2 4.3 0.0 -0.7 -0.6 -0.6 -1.3 -1.8 -1.0 -2.1 -0.9 0.2
Overall health rating 1.6 3.5 7.8 0.0 2.1 1.2 2.3 2.8 1.9 2.5 1.4 1.8 0.5
Chest pain or discomfort 0.4 0.6 1.7 0.0 0.0 -0.5 -0.8 -1.1 -0.5 -1.3 0.4 1.3 0.4
Had major operations 0.2 0.2 0.7 0.0 0.7 -0.8 0.8 -0.2 0.4 -0.0 0.0 -0.2 0.2
Age at last live birth 0.4 0.6 2.0 0.0 -0.4 -1.1 -1.4 -0.9 -0.0 0.8 0.7 -0.7 -0.6
Family relationship satisfaction 0.9 1.2 5.3 0.0 -0.7 -0.5 1.1 -0.6 -0.5 -2.3 0.6 -1.1 -1.5
Leg pain on walking 1.9 2.4 8.2 0.0 2.9 -0.9 -0.0 1.0 2.5 2.3 1.3 0.9 -0.2
Qualifications: NVQ or HND or HNC or equivalent 3.4 4.1 8.9 0.0 -1.8 -2.3 -0.3 -1.2 -2.7 -2.6 -3.0 -2.8 -0.3
Commuting to job workplace: Car/motor vehicle 1.1 1.2 4.1 0.0 1.4 1.0 1.1 2.0 1.2 -0.9 -0.2 -0.7 1.0
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.9 0.0 -0.3 0.2 0.7 -0.5 -0.3 0.3 -0.6 0.1 0.9
Medication: Aspirin 1.9 2.5 14.5 0.0 0.3 1.3 -1.8 -0.3 0.3 0.7 0.7 2.1 3.8
Supplements: Vitamin C 0.2 0.3 0.6 0.0 0.4 -0.2 -0.6 -0.8 0.7 -0.8 0.1 -0.0 -0.7
Knee pain experienced in last month 1.0 1.5 5.0 0.0 1.0 -0.5 1.5 2.2 1.1 0.3 1.7 -0.3 -1.5
Hypertension (Self-reported) 0.6 1.6 5.2 0.0 1.5 -0.5 -0.6 0.3 1.5 2.3 1.7 1.2 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 3.3 0.0 -0.9 -0.4 1.8 0.3 -0.7 -1.5 -1.2 -1.4 -0.5
Illnesses of father: Heart disease 1.5 2.0 16.6 0.0 0.4 -0.4 1.2 -0.6 -0.5 0.7 -0.3 0.8 4.1
Illnesses of siblings: Diabetes 0.4 0.4 1.8 0.0 -0.4 -1.4 -0.9 -0.6 -0.8 0.5 -0.1 -0.3 0.2
Smoking status: Previous 1.6 2.4 5.2 0.0 -2.2 -1.4 0.1 -1.9 -2.2 -0.5 -1.1 -2.3 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 3.2 0.0 -0.5 -0.3 -1.1 -0.2 -0.3 0.2 0.0 -0.9 -1.8
Whole body fat-free mass 0.5 2.7 14.4 0.0 -0.5 -0.7 -1.9 0.6 -0.3 0.9 2.0 -1.8 -3.8
Leg fat-free mass (right) 0.5 2.7 13.4 0.0 -0.5 -1.2 -1.9 0.3 -0.4 1.2 1.9 -1.7 -3.7
Arm fat percentage (left) 0.1 0.4 1.7 0.0 -0.0 -0.5 1.3 1.0 -0.6 0.4 0.1 0.2 0.3
Average weekly red wine intake 0.3 0.5 1.9 0.0 0.6 -0.9 0.2 -1.4 -0.2 0.3 -0.2 0.6 0.9
Handedness (chirality/laterality): Left-handed 1.2 1.4 4.1 0.0 -1.3 -1.7 -0.8 -1.6 -0.9 0.1 0.8 -0.9 -2.0
Mood swings 0.4 0.8 2.5 0.0 -0.1 -1.1 -0.9 -0.4 -0.6 -0.7 -1.6 -1.5 -0.4
Loneliness, isolation 0.4 0.5 1.7 0.0 0.1 -1.3 -0.5 0.4 -0.5 -0.8 -0.9 -1.2 0.2
Long-standing illness, disability or infirmity 1.7 2.5 6.3 0.0 1.8 2.5 -0.5 2.0 1.8 0.4 0.9 2.4 1.2
Ever had bowel cancer screening 1.7 2.0 4.9 0.0 1.8 1.6 -0.1 2.0 2.2 0.2 1.4 1.5 0.5
Diabetes diagnosed by doctor 2.8 4.7 11.8 0.0 2.0 1.9 1.1 2.9 2.9 3.4 2.2 2.0 0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.9 0.0 0.9 1.2 -1.3 0.9 0.9 -0.9 0.2 1.7 1.2
Friendships satisfaction 0.9 1.1 6.0 0.0 0.3 0.1 0.2 -0.2 0.9 -0.6 2.5 0.4 -1.8
Qualifications: nursing, teaching 0.3 0.5 2.8 0.0 0.3 0.1 -0.1 0.8 -0.0 1.0 -0.8 -0.4 1.7
Commuting to job workplace: Walk 0.7 0.7 2.8 0.0 0.4 0.8 -0.8 -0.0 0.9 1.1 0.8 1.7 0.6
Eye problems/disorders: Cataract 3.8 4.4 9.0 0.0 2.4 3.0 -0.5 2.7 2.7 1.1 1.2 2.3 2.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.6 2.1 0.0 0.0 -0.5 0.1 -0.5 -0.3 -1.4 -0.5 -0.7 -1.4
Medication for cholesterol 3.5 5.3 14.1 0.0 -2.4 -2.5 -0.7 -1.8 -1.8 -2.1 -1.6 -3.7 -3.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.4 0.0 1.5 0.4 -0.2 1.6 1.2 0.3 1.2 1.4 -0.2
Back pain experienced in last month 0.8 1.2 5.8 0.0 1.4 1.1 0.1 0.7 0.6 -0.2 -1.3 0.5 2.4
Mineral and other dietary supplements 0.2 0.3 0.8 0.0 -0.2 -0.9 -0.4 -0.8 -0.1 0.0 -0.9 -0.1 0.7
Breast cancer (self-reported) 0.7 0.9 2.8 0.0 0.3 0.7 -0.7 -0.2 1.2 -0.1 1.7 1.6 0.9
Asthma (self-reported) 2.0 4.1 9.3 0.0 2.2 3.0 1.8 2.0 2.6 1.5 0.8 3.0 1.0
Osteoporosis (self-reported) 0.5 0.6 3.3 0.0 0.7 -1.1 0.1 0.1 0.5 1.8 -0.5 0.4 -0.8
Osteoarthritis (self-reported) 0.5 0.7 2.0 0.0 1.2 1.4 -0.4 -0.0 1.2 -0.1 0.3 1.3 -0.6
Medication: Aspirin 2.2 2.9 14.2 0.0 0.6 1.5 -1.9 0.2 0.6 1.0 1.0 2.4 3.8
Medication: Gliclazide 0.6 0.6 2.5 0.0 0.1 1.1 -1.0 0.3 0.6 1.6 0.8 0.7 -0.4
Illnesses of father: None of the above (group 1) 0.5 0.7 3.2 0.0 -0.4 0.7 0.0 0.8 -0.1 -1.4 -0.3 -0.3 -1.8
Smoking status: Current 0.7 1.1 5.2 0.0 2.3 0.2 0.3 1.5 1.3 -0.1 0.1 0.2 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.6 0.0 0.1 0.3 1.0 1.3 0.6 0.9 0.5 0.1 0.1
Whole body water mass 0.5 2.6 14.0 0.0 -0.4 -0.7 -1.9 0.7 -0.2 0.9 2.0 -1.7 -3.7
Leg predicted mass (right) 0.5 2.7 13.3 0.0 -0.6 -1.3 -1.9 0.2 -0.4 1.3 1.8 -1.8 -3.6
Arm fat mass (left) 0.1 0.4 1.1 0.0 -0.1 -0.4 0.6 1.1 -0.6 0.5 0.9 -0.4 -0.9
Number of self-reported non-cancer illnesses 1.2 2.1 6.3 0.0 1.1 1.6 -1.1 1.1 1.3 0.8 1.0 2.3 2.5
Average weekly champagne plus white wine intake 0.6 0.8 2.1 0.0 0.5 0.7 1.1 0.3 1.0 1.5 1.2 1.1 -0.1
Miserableness 0.6 1.1 3.3 0.0 -1.4 -1.1 -0.4 -0.7 -1.2 -0.9 -0.2 -1.8 -1.2
Guilty feelings 1.2 1.8 5.8 0.0 -0.4 -1.7 -0.6 -1.9 -1.4 0.6 -1.6 -2.4 -0.6
Wears glasses or contact lenses 0.9 1.0 4.5 0.0 0.4 1.1 -0.0 0.2 0.5 1.3 0.8 2.1 1.2
Ever taken oral contraceptive pill 1.3 1.5 3.1 0.0 -0.9 -1.6 0.9 -0.9 -1.2 1.4 -1.4 -1.8 -1.3
Hearing aid user 2.2 2.5 7.2 0.0 1.0 2.7 0.2 2.4 1.3 1.8 0.6 2.0 1.4
Mother’s age at death 0.2 0.2 0.8 0.0 -0.8 0.9 -0.6 0.1 -0.7 0.0 -0.1 0.2 -0.2
Financial situation satisfaction 0.7 0.9 2.7 0.0 0.2 -0.4 0.4 1.6 0.7 0.5 1.5 -0.5 -1.5
Tinnitus: Yes, now most or all of the time 3.2 3.8 12.6 0.0 1.5 3.6 -0.2 1.6 1.9 1.8 1.1 3.2 1.4
Commuting to job workplace: Public transport 1.1 1.3 5.1 0.0 -1.2 -0.4 0.1 -1.7 -0.5 2.2 0.9 0.4 -1.7
Eye problems/disorders: Glaucoma 1.5 1.8 6.0 0.0 -1.2 1.6 -1.8 0.3 0.2 1.2 2.4 1.4 -1.2
Medication: Blood pressure 0.8 1.5 6.1 0.0 1.1 0.8 -0.5 1.0 1.3 1.3 2.5 1.4 0.2
Pain type(s) experienced in last month: Hip pain 1.3 1.6 3.9 0.0 2.0 1.2 0.8 2.0 1.4 0.4 1.5 1.1 1.1
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.7 0.0 -0.1 0.8 -0.9 -0.5 -0.5 -0.8 0.0 -0.3 0.1
High cholesterol (Self-reported) 12.5 22.1 166.4 0.0 1.2 3.0 -2.8 -0.6 0.7 0.2 0.7 5.9 12.9
Medication: Bendroflumethiazide 1.6 2.5 4.9 0.0 1.7 1.9 -0.6 1.4 2.2 1.2 2.1 2.2 0.5
Medication: Paracetamol 0.3 0.5 3.7 0.0 0.9 -0.1 0.3 1.9 0.2 0.4 0.2 -0.4 -0.3
Medication: Lisinopril 0.3 0.3 1.1 0.0 0.8 -0.6 -0.6 -0.2 -0.1 1.0 -0.4 0.3 0.8
Medication: Atorvastatin 4.1 5.1 36.2 0.0 -0.3 1.4 -1.2 -1.2 -0.1 -0.9 -0.1 2.9 6.0
Illnesses of father: High blood pressure 0.2 0.3 1.0 0.0 0.1 -0.5 -0.6 -1.0 -0.1 0.7 -0.3 0.5 -0.4
Alcohol drinker status: Never 1.2 1.5 6.4 0.0 0.2 0.8 -0.5 1.3 0.8 -1.2 2.5 1.3 -1.3
Ever smoked 0.2 0.3 1.3 0.0 0.0 0.2 -0.2 -0.6 -0.4 -0.1 -1.1 -0.9 0.1
Basal metabolic rate 0.4 2.3 12.4 0.0 -0.5 -0.6 -1.7 0.7 -0.5 0.8 1.8 -1.7 -3.5
Leg fat percentage (left) 0.2 0.6 1.5 0.0 -0.4 0.4 1.0 0.9 -1.2 -0.8 -0.6 0.1 1.0
Arm fat-free mass (left) 0.4 2.1 10.8 0.0 -0.6 -0.1 -1.5 0.9 -0.5 0.5 2.0 -1.5 -3.3
Number of operations (self-reported) 0.4 0.6 2.5 0.0 -0.2 -0.0 -1.1 -1.0 0.2 0.5 1.6 0.7 -0.6
Average weekly beer plus cider intake 1.0 1.4 6.9 0.0 -1.1 -1.4 -0.6 -0.1 -1.1 -0.4 -1.5 -2.6 -0.3
Irritability 0.6 1.1 4.8 0.0 0.0 -0.6 0.2 0.4 -0.8 -1.5 -2.2 -1.5 -0.3
Risk taking 0.9 1.4 5.3 0.0 2.3 0.7 -0.4 0.9 1.9 -0.2 -0.5 0.4 1.7
Ever had prostate specific antigen (PSA) test 1.4 1.6 6.2 0.0 0.7 1.3 0.4 1.4 1.4 0.6 2.5 1.8 0.2
Fractured/broken bones in last 5 years 1.4 1.8 4.0 0.0 -1.1 -1.8 -1.0 -2.0 -1.7 -0.1 -1.5 -0.8 -1.6
Age started oral contraceptive pill 0.5 0.6 2.3 0.0 -1.1 -0.3 -0.8 -1.5 -0.8 -0.5 0.7 -0.2 0.0
Diastolic blood pressure, automated reading 1.0 3.1 9.6 0.0 -1.6 -3.1 0.6 -1.5 -1.5 0.3 -0.2 -2.6 -2.6
Ever depressed for a whole week 0.1 0.1 0.8 0.0 -0.0 0.4 0.4 0.0 -0.2 -0.2 0.2 0.3 -0.9
Unable to work because of sickness or disability 0.3 0.4 1.9 0.0 -0.1 -0.9 -0.8 0.0 -0.1 -0.4 0.3 -0.5 -1.4
Commuting to job workplace: Cycle 0.6 0.7 1.9 0.0 1.4 0.4 0.3 0.6 1.3 -1.0 0.8 0.9 0.6
Myopia 1.2 1.7 5.2 0.0 1.0 -0.3 -0.2 0.0 1.9 2.2 1.0 1.2 -2.3
Vascular/heart problems diagnosed by doctor 0.6 1.6 5.5 0.0 -1.2 0.2 1.3 -0.4 -1.2 -1.8 -1.3 -1.0 -2.3
Cholesterol lowering medication 5.5 8.1 63.5 0.0 0.6 1.2 -1.6 -1.2 -0.8 -0.1 -1.1 3.1 8.0
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 7.1 0.0 0.7 1.7 0.1 2.7 1.5 0.0 1.0 2.1 1.1
Pain experienced in last month 0.5 0.9 6.5 0.0 0.7 -0.7 -0.3 -0.6 0.5 2.5 0.3 0.5 -0.3
Supplements: Calcium 0.2 0.2 0.6 0.0 -0.3 -0.7 -0.6 0.2 -0.3 0.4 0.4 0.4 -0.5
Basal cell carcinoma (self-reported) 0.4 0.5 1.0 0.0 0.6 0.9 -0.4 1.0 1.0 0.6 0.4 0.7 1.0
Heart attack/myocardial infarction (self-reported) 2.2 2.9 21.2 0.0 0.6 0.6 0.4 -0.3 0.4 1.5 -1.3 1.6 4.6
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 4.8 0.0 0.6 2.2 -0.7 1.2 1.2 0.2 0.3 1.4 1.3
Heart disease (siblings) 1.1 1.3 6.3 0.0 1.3 -1.0 0.8 -0.3 0.1 0.5 -1.6 0.8 2.5
Alcohol drinker status: Previous 0.3 0.4 1.1 0.0 -0.2 -0.7 -1.0 -0.6 -0.4 0.7 0.9 -0.1 -0.5
Pack years of smoking 0.4 0.6 2.1 0.0 -1.1 -0.6 -0.3 -1.0 -1.5 -0.1 -0.3 -1.0 0.3
Impedance of whole body 0.1 0.5 1.7 0.0 -0.3 1.3 0.0 -0.3 0.2 -1.0 -0.4 0.5 1.0
Leg fat mass (left) 0.1 0.3 1.5 0.0 -0.4 -0.1 0.4 1.2 -1.0 -0.0 0.2 -0.6 -0.5
Arm predicted mass (left) 0.4 2.2 11.0 0.0 -0.4 -0.1 -1.4 1.0 -0.4 0.6 2.0 -1.6 -3.3