TWAS hub - EPOR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.109	0.0350	0.00025	0.035	NA	0.023	NA	0.039	6.8e-04	NA	5.4e-03	NA	3.8e-04
2	YFS	Blood	0.277	0.0383	0.00000	0.047	0.108	0.114	0.096	0.094	5.2e-15	2.2e-33	3.0e-35	8.5e-30	3.7e-29

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
LDL Cholesterol	48.6	76.9	153.8	-12.4	-0.4
High cholesterol (Self-reported)	35.4	62.8	125.4	-11.2	-0.4
Cholesterol lowering medication	21.5	31.6	62.9	-7.9	-0.6
Medication: Simvastatin	17.1	25.1	50.1	-7.1	-0.2
Medication: Cholesterol lowering	16.1	25.0	49.9	-7.1	-0.2
Medication: Atorvastatin	15.7	19.4	35.8	-6.0	-1.8
Coronary Artery Disease (CAD)	12.6	15.1	30.0	-5.5	-0.3
Medication for cholesterol, blood pressure or diabetes	8.0	13.2	26.3	5.1	-0.3
Cardiovascular Disease	7.6	25.0	49.9	-7.1	0.2
Illnesses of father: Heart disease	7.2	10.0	18.3	-4.3	1.3
Medication: Aspirin	6.1	7.9	15.8	-4.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	5.3	10.9	11.2	3.3	3.3
Medication: Aspirin	5.2	6.9	13.3	-3.6	-0.6
Primary Biliary Cirrhosis	4.5	6.5	12.8	-3.6	0.3
Asthma	4.3	8.5	9.1	2.8	3.0
Forced expiratory volume in 1-second (FEV1), Best measure	4.0	12.7	25.5	5.0	0.1
Illnesses of father: None of the above (group 1)	4.0	4.9	9.1	3.0	-0.8
Knee pain experienced in last month	3.7	5.8	8.8	3.0	-1.7
Hearing aid user	3.7	4.2	8.3	0.4	2.9
Heart disease (siblings)	3.7	4.6	8.9	-3.0	-0.4
Birth weight of first child	3.6	6.5	11.8	3.4	1.1
Asthma (self-reported)	3.6	7.2	9.4	2.3	3.1
Medication: Atenolol	3.5	4.3	8.4	-2.9	0.6
Heart disease (mother)	3.5	4.3	8.6	-2.9	0.1
Trunk fat-free mass	3.4	19.3	30.4	5.5	2.9
Trunk predicted mass	3.3	19.1	29.7	5.5	2.9
Average weekly fortified wine intake	3.2	3.8	4.6	-1.7	-2.1
Forced expiratory volume in 1-second (FEV1)	3.1	10.5	20.7	4.5	0.6
Forced vital capacity (FVC), Best measure	3.1	11.2	19.3	4.4	1.8
Arm fat-free mass (right)	3.1	15.8	23.7	4.9	2.8
Medication for cholesterol	3.1	4.6	8.9	3.0	0.6
Arm predicted mass (left)	3.1	15.7	25.8	5.1	2.4
Ever smoked	3.0	5.2	8.1	1.5	2.8
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.5	6.4	0.8	2.5
Arm fat-free mass (left)	2.9	14.7	23.0	4.8	2.5
Pain experienced in last month	2.9	4.8	7.1	-2.7	-1.6
Angina	2.8	3.6	7.1	-2.7	-0.3
Reaction Time	2.7	5.2	7.3	-2.7	-1.7
Lupus	2.7	4.0	8.0	0.2	2.8
Number of treatments/medications taken	2.7	4.8	7.0	-2.6	1.6
Whole body fat-free mass	2.7	15.6	26.2	5.1	2.2
Whole body water mass	2.7	15.3	25.2	5.0	2.3
Stomach or abdominal pain in last month	2.6	3.2	4.3	2.1	1.4
Medication: Levothyroxine sodium	2.6	4.4	4.9	-2.2	-2.0
Risk taking	2.6	3.9	6.1	-1.3	2.5
Peak expiratory flow (PEF)	2.5	5.9	11.6	3.4	-0.3
Arm predicted mass (right)	2.5	13.0	20.6	4.5	2.3
Basal metabolic rate	2.5	14.0	24.7	5.0	1.8
Mean time to correctly identify matches	2.4	4.6	7.4	-2.7	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.8	5.6	-2.4	0.1
Ever depressed for a whole week	2.4	3.0	4.5	-2.1	1.2
Forced vital capacity (FVC)	2.3	8.9	14.4	3.8	1.8
Heart attack	2.3	2.9	5.1	-2.3	0.9
Angina (self-reported)	2.3	3.0	5.8	-2.4	-0.4
Commuting to job workplace: Walk	2.3	2.5	3.0	-1.7	-1.4
Systolic blood pressure, automated reading	2.2	6.3	11.6	-3.4	-1.0
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	5.0	-0.7	2.2
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	3.0	1.6	1.7
Standing height	2.2	22.1	36.1	6.0	2.9
Medication: Paracetamol	2.2	3.7	7.2	2.7	0.4
Age at last live birth	2.2	3.2	6.3	0.0	-2.5
Handedness (chirality/laterality): Left-handed	2.2	2.6	4.6	-0.8	-2.1
Osteoarthritis (self-reported)	2.2	2.9	3.5	1.5	1.9
Medication: Paracetamol	2.2	3.4	6.5	2.5	0.5
Family relationship satisfaction	2.1	2.6	3.8	2.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	8.7	3.0	-0.5
Respiratory disease	2.0	4.4	4.9	2.0	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	3.5	1.3	1.9
Wheeze or whistling in the chest in last year	2.0	3.6	5.3	1.4	2.3
Eye problems/disorders: Cataract	2.0	2.4	4.0	-2.0	0.8
Financial situation satisfaction	2.0	2.5	3.3	1.8	1.3
Heart attack/myocardial infarction (self-reported)	2.0	2.6	4.9	-2.2	0.5
Bipolar Disorder (2018)	1.9	3.1	6.1	-2.5	-0.0
Systolic Blood Pressure	1.9	9.4	17.3	-4.2	-1.2
Leg fat-free mass (left)	1.9	9.8	18.7	4.3	1.0
Leg predicted mass (left)	1.9	10.3	19.4	4.4	1.0
Weight	1.9	9.2	18.0	4.2	0.6
Supplements: Zinc	1.8	2.0	3.5	0.6	1.9
Severe depression (siblings)	1.8	2.0	3.7	-1.9	0.5
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	3.1	1.1	1.8
Pulse wave reflection index	1.8	2.2	3.1	1.8	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.0	3.8	-1.9	0.6
Number of full sisters	1.8	2.2	3.6	-0.9	1.9
Long-standing illness, disability or infirmity	1.8	2.7	2.9	-1.7	1.6
Migraine (self-reported)	1.7	2.1	3.2	1.8	1.0
Leg fat-free mass (right)	1.7	8.9	17.0	4.1	0.9
Breast cancer (self-reported)	1.7	2.1	3.9	-2.0	-0.4
Leg predicted mass (right)	1.7	9.2	17.5	4.2	0.9
Number of self-reported non-cancer illnesses	1.7	3.0	3.8	-2.0	1.5
Hypothyroidism (self reported)	1.6	3.6	3.9	-2.0	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	4.9	1.5	-2.2
Qualifications: CSEs or equivalent	1.6	2.1	3.2	1.8	1.1
Alcohol usually taken with meals	1.6	2.6	3.0	-1.7	-1.5
Number of live births	1.6	2.2	2.4	-1.5	-1.4
Noisy workplace	1.6	1.9	2.7	1.1	-1.7
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	5.8	-2.4	-0.8
High blood pressure (siblings)	1.6	2.4	2.4	-1.6	-1.5
Pulse wave peak to peak time	1.6	1.9	2.3	1.2	1.5
Vascular/heart problems diagnosed by doctor	1.6	4.4	8.8	3.0	-0.1
Major Depression (MDD)	1.5	1.9	3.6	-1.9	0.3
Blood Eosinophil Count	1.5	11.6	17.2	4.2	2.5
Multivitamins +/- minerals	1.5	1.9	2.1	1.3	1.4
Birth weight	1.5	3.2	5.6	2.4	-0.8
Neck or shoulder pain in last month	1.5	2.1	2.6	1.3	1.6
Comparative height size at age 10	1.5	8.1	12.0	2.1	3.5
Illnesses of siblings: Diabetes	1.5	1.9	2.0	-1.3	-1.4
Smoking status: Previous	1.5	2.2	2.5	1.6	1.4
Height	1.4	27.9	46.4	6.8	3.1
Vitamin and mineral supplements	1.4	1.9	2.7	-1.6	-1.0
Had other major operations	1.4	1.8	3.0	1.7	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	2.9	1.7	0.8
Blood clot in the leg (DVT)	1.4	1.9	3.7	-1.9	0.0
Medication: Blood pressure	1.4	2.5	4.7	-2.2	0.6
Medication: Ibuprofen	1.4	1.6	2.9	1.7	0.6
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	2.7	1.7	-1.3
Diabetes (father)	1.3	1.6	2.2	1.5	-1.0
Past tobacco smoking	1.3	2.4	3.2	-1.3	-1.8
Illnesses of siblings	1.3	1.9	3.0	1.7	0.8
Illnesses of mother	1.3	1.7	2.9	1.7	-0.6
Fasting Glucose	1.2	1.4	1.8	1.3	1.0
Age when periods started (menarche)	1.2	2.9	5.5	2.4	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	3.2	0.8	1.8
Hip circumference	1.2	5.2	10.3	3.2	-0.3
Depression (self-reported)	1.2	1.4	2.6	0.4	1.6
Pulse wave Arterial Stiffness index	1.2	1.4	2.2	-0.7	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	1.6	-1.2	1.3
Average weekly champagne plus white wine intake	1.2	1.6	1.8	-1.2	-1.4
Medication: Lisinopril	1.2	1.5	1.6	-1.2	1.3
Irritability	1.2	2.0	3.2	0.9	1.8
Age started oral contraceptive pill	1.2	1.5	2.9	0.3	-1.7
Supplements: Calcium	1.2	1.3	2.3	-0.5	1.5
Alcohol drinker status: Previous	1.2	1.4	2.4	-1.6	-0.5
Schizophrenia vs Biploar Disorder	1.1	1.4	2.1	1.4	0.8
Nervous feelings	1.1	2.0	3.9	-2.0	0.0
Hearing difficulty/problems with background noise	1.1	1.8	3.5	-1.9	0.3
Financial difficulties in last 2 years	1.1	1.5	2.7	1.6	-0.5
Qualifications: College or University degree	1.1	3.3	4.0	-2.0	-1.6
Emphysema/chronic bronchitis	1.1	1.2	2.2	-1.5	0.4
Mineral and other dietary supplements	1.1	1.5	2.9	-0.2	-1.7
Ever had prostate specific antigen (PSA) test	1.1	1.2	1.6	-1.3	0.9
Body Mass Index (BMI) (2010)	1.0	1.3	2.6	1.6	0.1
Ulcerative Colitis	1.0	1.5	2.9	0.1	-1.7
Fed-up feelings	1.0	1.9	3.5	1.9	0.5
High blood pressure	1.0	2.7	5.4	-2.3	-0.1
Sitting height	1.0	6.8	9.8	3.1	2.0
Number of incorrect matches in round	1.0	1.7	2.4	1.1	1.5
Medication: Ramipril	1.0	1.3	1.9	-0.8	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.1	1.0	1.1
Exposure to tobacco smoke at home	1.0	1.1	1.7	-0.7	1.3
Eye problems/disorders: None of the above	1.0	1.2	1.3	1.1	-1.0
Commuting to job workplace: Car/motor vehicle	1.0	1.1	1.8	0.7	1.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	2.1	-1.4	-0.6
Hypertension (Self-reported)	1.0	2.9	5.8	-2.4	0.1
Qualifications: nursing, teaching	1.0	1.6	2.7	0.7	-1.6
Medication: Blood pressure	1.0	1.9	3.0	-1.7	-0.9
Fractured/broken bones in last 5 years	1.0	1.3	2.1	1.4	0.7
Crohns Disease (2017)	0.9	1.9	3.3	-1.8	-0.7
Blood White Count	0.9	6.6	12.1	3.5	1.1
Smoking Status	0.9	2.1	2.4	1.6	1.3
Medication: Co-codamol	0.9	1.1	2.0	0.4	1.4
Allergy	0.9	2.2	3.6	-0.8	-1.9
Impedance of arm (left)	0.9	4.0	6.1	-2.5	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.1	0.3	1.4
Osteoporosis (self-reported)	0.9	1.1	1.4	0.9	-1.2
Average weekly beer plus cider intake	0.9	1.2	2.3	1.5	0.5
Depression (Nagel 2018)	0.8	1.2	2.3	0.2	1.5
Schizophrenia (2018)	0.8	1.7	3.3	0.3	1.8
Blood Platelet Count	0.8	9.2	10.7	2.8	3.3
Trunk fat mass	0.8	3.3	6.2	2.5	-0.6
Arm fat mass (right)	0.8	3.5	6.8	2.6	-0.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.3	0.7	-1.1
Number of full brothers	0.8	1.0	1.8	0.5	-1.3
Shortness of breath walking on level ground	0.8	1.0	1.9	-0.2	1.4
Leg fat mass (right)	0.8	3.3	6.4	2.5	-0.3
Friendships satisfaction	0.8	1.0	1.3	1.1	0.8
Arm fat mass (left)	0.8	3.1	6.0	2.4	-0.6
Eye problems/disorders: Glaucoma	0.8	1.0	1.8	-1.3	-0.4
Depressed Affect (Nagel 2018)	0.7	1.4	2.6	1.6	0.4
Mean Putamen Volume	0.7	0.8	1.6	1.3	-0.3
Medication for hormone replacement therapy	0.7	0.8	1.6	1.2	0.2
Diabetes (mother)	0.7	0.9	1.8	1.3	-0.3
Taking other prescription medications	0.7	1.0	1.5	-0.8	1.2
Waist circumference	0.7	2.5	4.9	2.2	0.4
Pulse rate	0.7	1.2	2.4	-1.5	0.1
Happiness	0.7	0.8	1.5	0.3	1.2
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.8	-0.4	-1.7
Medication: Omeprazole	0.7	0.8	1.4	-1.2	0.4
Whole body fat mass	0.7	3.1	6.0	2.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.5	-1.2	-0.3
Mother’s age at death	0.7	0.8	1.6	0.3	-1.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.1	0.7	-1.0
Basal cell carcinoma (self-reported)	0.7	0.8	0.9	-1.0	-0.8
Leg fat mass (left)	0.7	2.6	5.2	2.3	-0.3
Bipolar Disorder or Schizophrenia	0.6	1.6	1.8	-1.3	1.2
Schizophrenia (2014)	0.6	1.4	1.9	-0.9	1.4
Heel T-Score	0.6	5.0	6.9	2.6	-1.8
Lung FEV1/FVC ratio	0.6	3.2	5.1	2.3	-1.1
Tanning	0.6	7.3	14.6	-3.8	-0.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.0	0.8	1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	0.9	-0.9	-0.9
Hand grip strength (right)	0.6	1.7	3.1	1.8	-0.6
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.5	0.4	1.6
High blood pressure (mother)	0.6	0.8	1.6	-1.2	0.1
Time employed in main current job	0.6	0.6	0.7	-0.8	0.8
Hair/balding pattern: Pattern 3	0.6	0.8	1.7	-1.3	-0.0
Medication: Lansoprazole	0.6	0.7	0.8	0.7	0.9
Breastfed as a baby	0.6	0.8	1.0	-1.0	0.8
Tense / ‘highly strung’	0.6	1.0	1.4	1.2	0.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.3	-0.4	1.1
Headache pain in last month	0.6	1.0	1.8	1.3	0.4
Medication: Amlodipine	0.6	0.9	1.0	-1.0	-0.9
Supplements: Vitamin C	0.6	0.7	0.8	-0.7	0.9
Wears glasses or contact lenses	0.6	0.7	1.3	-1.2	0.1
Ever taken oral contraceptive pill	0.6	0.7	1.2	1.1	0.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	-0.3	1.2
Illnesses of father: High blood pressure	0.6	0.8	1.0	-0.8	1.0
Number of operations (self-reported)	0.6	0.9	1.7	-0.4	1.3
Ulcerative Colitis (UC)	0.5	0.9	1.0	0.8	-1.0
Crohns Disease (2012)	0.5	0.9	1.7	-1.3	-0.2
HbA1C	0.5	0.6	1.0	1.0	0.4
HDL Cholesterol	0.5	0.9	1.8	1.4	0.0
Body mass index (BMI)	0.5	1.9	3.2	1.8	-0.8
Pain all over the body in last month	0.5	0.6	0.8	0.9	0.6
Fluid intelligence score	0.5	1.0	1.5	-1.2	-0.8
Impedance of arm (right)	0.5	2.5	3.4	-1.8	-1.3
Alcohol intake versus 10 years previously	0.5	0.8	1.5	1.2	0.3
Worrier / anxious feelings	0.5	1.0	1.1	-1.1	-1.0
Prospective memory result	0.5	0.6	0.8	-0.9	-0.6
Hair/balding pattern: Pattern 4	0.5	1.2	1.5	-0.9	-1.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	-0.4	1.0
Age at first live birth	0.5	0.8	1.6	-0.1	-1.3
Medication: Seretide 50 evohaler	0.5	0.6	1.1	0.3	1.1
Pulse rate, automated reading	0.5	1.5	2.8	1.7	0.3
Leg pain on walking	0.5	0.6	0.7	0.8	-0.7
Back pain experienced in last month	0.5	0.7	1.3	0.2	1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.2	-1.1	0.3
Irritable Bowel Disease (IBD)	0.4	1.0	1.3	-1.2	-0.8
Ovarian Cancer	0.4	0.5	0.8	-0.9	0.5
Triglycerides	0.4	0.7	1.3	-1.1	-0.0
Blood Red Count	0.4	3.6	7.1	2.7	-0.4
Hair Pigment	0.4	10.1	17.7	-4.2	-1.6
Hearing difficulty/problems: Yes	0.4	0.7	0.8	0.7	0.9
Trunk fat percentage	0.4	1.8	2.3	1.1	-1.5
Maternal smoking around birth	0.4	0.6	0.9	1.0	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.3	0.6	-1.2
Mouth/teeth dental problems	0.4	0.6	0.9	0.5	1.0
Arm fat percentage (right)	0.4	1.6	1.9	1.1	-1.4
Length of working week for main job	0.4	0.4	0.5	0.7	-0.6
Overall health rating	0.4	1.0	1.9	1.4	0.2
Chest pain or discomfort	0.4	0.6	0.9	-1.0	0.4
Arm fat percentage (left)	0.4	1.8	2.8	0.9	-1.7
Loneliness, isolation	0.4	0.6	1.2	1.1	-0.2
Ever had bowel cancer screening	0.4	0.5	0.7	-0.5	-0.8
Medication: Bendroflumethiazide	0.4	0.5	0.6	-0.7	-0.8
Commuting to job workplace: Cycle	0.4	0.4	0.9	0.1	-0.9
Myopia	0.4	0.6	1.1	0.2	1.1
Impedance of whole body	0.4	2.1	3.8	-1.9	-0.7
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.9	1.4	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	0.4	-0.7	0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.3	0.1	-1.2
Rheumatoid Arthritis	0.3	0.4	0.8	0.9	0.3
BMI	0.3	1.9	3.5	1.9	0.6
Waist Hip Ratio (WHR)	0.3	1.2	1.9	-0.7	1.4
Chronotype (morning person)	0.3	0.6	1.1	-0.3	-1.0
Hand grip strength (left)	0.3	0.8	1.5	1.2	0.1
Ever had hysterectomy (womb removed)	0.3	0.4	0.8	-0.0	-0.9
Serious illness, injury or assault to yourself	0.3	0.4	0.4	-0.6	-0.6
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	0.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	-1.0	0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.5	0.7	0.5
Body fat percentage	0.3	1.3	1.8	0.9	-1.3
Worry too long after embarrassment	0.3	0.6	1.0	-0.5	-1.0
Alcohol intake frequency.	0.3	0.8	1.2	-0.6	-1.1
Mood swings	0.3	0.5	0.8	0.3	0.9
Diabetes diagnosed by doctor	0.3	0.4	0.6	-0.6	-0.8
Neuroticism (Nagel 2018)	0.2	0.5	0.8	0.9	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.0	0.6
Prostate Cancer	0.2	0.3	0.5	0.3	0.7
Neuroticism (2016)	0.2	0.3	0.4	0.6	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.4	0.3	-0.6
Sensitivity / hurt feelings	0.2	0.4	0.8	-0.1	-0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.2	-0.5	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.5	-0.0	0.7
Medication: Metformin	0.2	0.3	0.5	-0.4	-0.7
Current tobacco smoking	0.2	0.3	0.6	0.3	0.8
Supplements: Glucosamine	0.2	0.3	0.4	0.6	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.6	-0.4
Had menopause	0.2	0.2	0.2	-0.5	-0.4
Father’s age at death	0.2	0.3	0.5	0.7	0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	-0.4	-0.6
Lung cancer (father)	0.2	0.2	0.2	0.5	0.5
Loud music exposure frequency	0.2	0.2	0.3	0.5	0.4
Gout (self-reported)	0.2	0.2	0.3	0.6	0.3
Leg fat percentage (right)	0.2	0.7	0.9	1.0	-0.8
Exposure to tobacco smoke outside home	0.2	0.2	0.5	0.1	0.7
Comparative body size at age 10	0.2	0.6	0.7	-0.7	-0.8
Average weekly red wine intake	0.2	0.4	0.6	-0.8	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	0.6	-0.3
Medication: Gliclazide	0.2	0.2	0.5	-0.7	-0.1
Smoking status: Current	0.2	0.4	0.4	0.5	0.7
Alcohol drinker status: Never	0.2	0.3	0.3	-0.5	-0.5
Unable to work because of sickness or disability	0.2	0.3	0.6	0.2	0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.4	-0.7	0.3
Worry (Nagel 2018)	0.1	0.2	0.4	-0.3	0.6
Breast Cancer	0.1	0.3	0.3	-0.5	-0.6
Age at First Birth	0.1	0.1	0.3	-0.5	-0.1
Lung FVC	0.1	0.7	1.3	1.2	0.1
Neuroticism	0.1	0.3	0.5	0.7	0.3
Average weekly spirits intake	0.1	0.1	0.2	0.3	-0.4
Relative age of first facial hair	0.1	0.3	0.6	0.7	0.1
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.1	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.3	-0.1
Impedance of leg (left)	0.1	0.7	1.3	-1.1	0.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.2	0.4	-0.4
Qualifications: None of the above	0.1	0.2	0.4	-0.0	-0.6
Diabetes (self-reported)	0.1	0.2	0.4	-0.0	-0.6
Neuroticism score	0.1	0.2	0.5	-0.0	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.5	-0.1
Glaucoma (self-reported)	0.1	0.1	0.1	-0.1	-0.4
Health satisfaction	0.1	0.1	0.3	-0.5	-0.0
Medication: Allopurinol	0.1	0.2	0.3	0.6	0.0
Suffer from ‘nerves’	0.1	0.2	0.2	-0.4	0.4
Had major operations	0.1	0.1	0.2	0.4	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.1	-0.1	0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	0.4	0.2
Leg fat percentage (left)	0.1	0.5	0.7	0.5	-0.9
Diastolic blood pressure, automated reading	0.1	0.4	0.8	0.0	-0.9
Pack years of smoking	0.1	0.1	0.2	-0.2	-0.5
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.2	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Allergy or Eczema	0.0	0.1	0.3	0.0	0.5
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	-0.1	-0.3
Pack years adult smoking proportion	0.0	0.0	0.1	0.0	-0.3
Impedance of leg (right)	0.0	0.2	0.3	-0.5	0.4
Relative age voice broke	0.0	0.0	0.0	0.2	-0.2
Falls in the last year	0.0	0.0	0.0	-0.1	-0.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.2	-0.1
Number of children fathered	0.0	0.0	0.1	0.0	0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.1	0.1	0.3
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	-0.0	0.0
Miserableness	0.0	0.0	0.0	0.1	-0.1
Guilty feelings	0.0	0.1	0.1	-0.1	0.3

Hub : Genes

EPOR

Models

Trait associations