Hub : Genes

EPOR

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.109 0.0350 0.00025 0.035 NA 0.023 NA 0.039 6.8e-04 NA 5.4e-03 NA 3.8e-04
2 YFS Blood 0.277 0.0383 0.00000 0.047 0.108 0.114 0.096 0.094 5.2e-15 2.2e-33 3.0e-35 8.5e-30 3.7e-29

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.9 3.1 6.1 -2.5 -0.0
Bipolar Disorder or Schizophrenia 0.6 1.6 1.8 -1.3 1.2
Depressed Affect (Nagel 2018) 0.7 1.4 2.6 1.6 0.4
Depression (Nagel 2018) 0.8 1.2 2.3 0.2 1.5
Intelligence (Savage-Jansen 2018) 0.3 1.0 1.9 1.4 -0.4
Neuroticism (Nagel 2018) 0.2 0.5 0.8 0.9 0.4
Schizophrenia (2018) 0.8 1.7 3.3 0.3 1.8
Schizophrenia vs Biploar Disorder 1.1 1.4 2.1 1.4 0.8
Worry (Nagel 2018) 0.1 0.2 0.4 -0.3 0.6
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 -0.2 -0.1
Alzheimer’s Disease (in father) 0.2 0.2 0.4 0.0 0.6
Alzheimer’s Disease (including proxy) 0.3 0.4 0.4 -0.7 0.6
Crohns Disease (2017) 0.9 1.9 3.3 -1.8 -0.7
Irritable Bowel Disease (IBD) 0.4 1.0 1.3 -1.2 -0.8
Ulcerative Colitis (UC) 0.5 0.9 1.0 0.8 -1.0
Major Depression (MDD) 1.5 1.9 3.6 -1.9 0.3
Reaction Time 2.7 5.2 7.3 -2.7 -1.7
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.3 0.1 -1.2
Breast Cancer 0.1 0.3 0.3 -0.5 -0.6
Ovarian Cancer 0.4 0.5 0.8 -0.9 0.5
Prostate Cancer 0.2 0.3 0.5 0.3 0.7
Age at First Birth 0.1 0.1 0.3 -0.5 -0.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.3 2.6 1.6 0.1
Coronary Artery Disease (CAD) 12.6 15.1 30.0 -5.5 -0.3
Crohns Disease (2012) 0.5 0.9 1.7 -1.3 -0.2
Mean Putamen Volume 0.7 0.8 1.6 1.3 -0.3
Fasting Glucose 1.2 1.4 1.8 1.3 1.0
HbA1C 0.5 0.6 1.0 1.0 0.4
HDL Cholesterol 0.5 0.9 1.8 1.4 0.0
LDL Cholesterol 48.6 76.9 153.8 -12.4 -0.4
Lupus 2.7 4.0 8.0 0.2 2.8
Neuroticism (2016) 0.2 0.3 0.4 0.6 0.6
Primary Biliary Cirrhosis 4.5 6.5 12.8 -3.6 0.3
Rheumatoid Arthritis 0.3 0.4 0.8 0.9 0.3
Schizophrenia (2014) 0.6 1.4 1.9 -0.9 1.4
Triglycerides 0.4 0.7 1.3 -1.1 -0.0
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.4 0.3 -0.6
Ulcerative Colitis 1.0 1.5 2.9 0.1 -1.7
Blood Eosinophil Count 1.5 11.6 17.2 4.2 2.5
Blood Platelet Count 0.8 9.2 10.7 2.8 3.3
Blood Red Count 0.4 3.6 7.1 2.7 -0.4
Blood White Count 0.9 6.6 12.1 3.5 1.1
Heel T-Score 0.6 5.0 6.9 2.6 -1.8
BMI 0.3 1.9 3.5 1.9 0.6
Height 1.4 27.9 46.4 6.8 3.1
Waist Hip Ratio (WHR) 0.3 1.2 1.9 -0.7 1.4
Systolic Blood Pressure 1.9 9.4 17.3 -4.2 -1.2
Smoking Status 0.9 2.1 2.4 1.6 1.3
Allergy or Eczema 0.0 0.1 0.3 0.0 0.5
Cardiovascular Disease 7.6 25.0 49.9 -7.1 0.2
Hypothyroidism (self reported) 1.6 3.6 3.9 -2.0 -1.8
Respiratory disease 2.0 4.4 4.9 2.0 2.2
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.1 -0.1 -0.3
Lung FEV1/FVC ratio 0.6 3.2 5.1 2.3 -1.1
Lung FVC 0.1 0.7 1.3 1.2 0.1
Neuroticism 0.1 0.3 0.5 0.7 0.3
Chronotype (morning person) 0.3 0.6 1.1 -0.3 -1.0
Hair Pigment 0.4 10.1 17.7 -4.2 -1.6
Tanning 0.6 7.3 14.6 -3.8 -0.1
Hand grip strength (left) 0.3 0.8 1.5 1.2 0.1
Number of treatments/medications taken 2.7 4.8 7.0 -2.6 1.6
Average weekly spirits intake 0.1 0.1 0.2 0.3 -0.4
Sensitivity / hurt feelings 0.2 0.4 0.8 -0.1 -0.9
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.0 0.8 1.0
Hearing difficulty/problems: Yes 0.4 0.7 0.8 0.7 0.9
Relative age of first facial hair 0.1 0.3 0.6 0.7 0.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.2 -0.5 0.4
Ever used hormone-replacement therapy (HRT) 0.6 0.8 0.9 -0.9 -0.9
Ever had hysterectomy (womb removed) 0.3 0.4 0.8 -0.0 -0.9
Systolic blood pressure, automated reading 2.2 6.3 11.6 -3.4 -1.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.5 -0.0 0.7
Angina 2.8 3.6 7.1 -2.7 -0.3
Medication for hormone replacement therapy 0.7 0.8 1.6 1.2 0.2
Vitamin and mineral supplements 1.4 1.9 2.7 -1.6 -1.0
Supplements: Zinc 1.8 2.0 3.5 0.6 1.9
Medication: Co-codamol 0.9 1.1 2.0 0.4 1.4
Medication: Metformin 0.2 0.3 0.5 -0.4 -0.7
Diabetes (father) 1.3 1.6 2.2 1.5 -1.0
Diabetes (mother) 0.7 0.9 1.8 1.3 -0.3
Severe depression (siblings) 1.8 2.0 3.7 -1.9 0.5
Pack years adult smoking proportion 0.0 0.0 0.1 0.0 -0.3
Impedance of leg (right) 0.0 0.2 0.3 -0.5 0.4
Leg fat-free mass (left) 1.9 9.8 18.7 4.3 1.0
Trunk fat percentage 0.4 1.8 2.3 1.1 -1.5
Hand grip strength (right) 0.6 1.7 3.1 1.8 -0.6
Townsend deprivation index at recruitment 0.1 0.1 0.2 0.1 -0.5
Current tobacco smoking 0.2 0.3 0.6 0.3 0.8
Average weekly fortified wine intake 3.2 3.8 4.6 -1.7 -2.1
Maternal smoking around birth 0.4 0.6 0.9 1.0 -0.6
Fed-up feelings 1.0 1.9 3.5 1.9 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 3.5 1.3 1.9
Relative age voice broke 0.0 0.0 0.0 0.2 -0.2
Taking other prescription medications 0.7 1.0 1.5 -0.8 1.2
Age when periods started (menarche) 1.2 2.9 5.5 2.4 0.5
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 3.1 1.1 1.8
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.6 4.9 1.5 -2.2
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 0.3 -0.1
Qualifications: CSEs or equivalent 1.6 2.1 3.2 1.8 1.1
Serious illness, injury or assault to yourself 0.3 0.4 0.4 -0.6 -0.6
High blood pressure 1.0 2.7 5.4 -2.3 -0.1
Hayfever, allergic rhinitis or eczema 0.6 1.4 2.5 0.4 1.6
Multivitamins +/- minerals 1.5 1.9 2.1 1.3 1.4
Stomach or abdominal pain in last month 2.6 3.2 4.3 2.1 1.4
Supplements: Glucosamine 0.2 0.3 0.4 0.6 -0.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.3 0.6 -0.4
Medication: Atenolol 3.5 4.3 8.4 -2.9 0.6
Medication: Levothyroxine sodium 2.6 4.4 4.9 -2.2 -2.0
Sitting height 1.0 6.8 9.8 3.1 2.0
Chronic bronchitis/emphysema (father) 0.3 0.4 0.6 0.3 0.8
High blood pressure (mother) 0.6 0.8 1.6 -1.2 0.1
Body mass index (BMI) 0.5 1.9 3.2 1.8 -0.8
Impedance of leg (left) 0.1 0.7 1.3 -1.1 0.3
Leg predicted mass (left) 1.9 10.3 19.4 4.4 1.0
Trunk fat mass 0.8 3.3 6.2 2.5 -0.6
Waist circumference 0.7 2.5 4.9 2.2 0.4
Number of incorrect matches in round 1.0 1.7 2.4 1.1 1.5
Past tobacco smoking 1.3 2.4 3.2 -1.3 -1.8
Alcohol usually taken with meals 1.6 2.6 3.0 -1.7 -1.5
Nervous feelings 1.1 2.0 3.9 -2.0 0.0
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 3.2 0.8 1.8
Hearing difficulty/problems with background noise 1.1 1.8 3.5 -1.9 0.3
Hair/balding pattern: Pattern 2 0.1 0.2 0.2 0.4 -0.4
Had menopause 0.2 0.2 0.2 -0.5 -0.4
Had other major operations 1.4 1.8 3.0 1.7 0.8
Forced vital capacity (FVC) 2.3 8.9 14.4 3.8 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 1.3 0.6 -1.2
Ever unenthusiastic/disinterested for a whole week 2.2 2.7 5.0 -0.7 2.2
Qualifications: None of the above 0.1 0.2 0.4 -0.0 -0.6
Financial difficulties in last 2 years 1.1 1.5 2.7 1.6 -0.5
Mouth/teeth dental problems 0.4 0.6 0.9 0.5 1.0
Heart attack 2.3 2.9 5.1 -2.3 0.9
Allergy 0.9 2.2 3.6 -0.8 -1.9
Pain all over the body in last month 0.5 0.6 0.8 0.9 0.6
Diabetes (self-reported) 0.1 0.2 0.4 -0.0 -0.6
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 3.0 1.6 1.7
Medication: Ramipril 1.0 1.3 1.9 -0.8 -1.4
Medication: Simvastatin 17.1 25.1 50.1 -7.1 -0.2
Fluid intelligence score 0.5 1.0 1.5 -1.2 -0.8
Illnesses of siblings 1.3 1.9 3.0 1.7 0.8
Neuroticism score 0.1 0.2 0.5 -0.0 -0.7
Weight 1.9 9.2 18.0 4.2 0.6
Impedance of arm (right) 0.5 2.5 3.4 -1.8 -1.3
Arm fat percentage (right) 0.4 1.6 1.9 1.1 -1.4
Trunk fat-free mass 3.4 19.3 30.4 5.5 2.9
Hip circumference 1.2 5.2 10.3 3.2 -0.3
Time employed in main current job 0.6 0.6 0.7 -0.8 0.8
Alcohol intake versus 10 years previously 0.5 0.8 1.5 1.2 0.3
Father’s age at death 0.2 0.3 0.5 0.7 0.3
Worrier / anxious feelings 0.5 1.0 1.1 -1.1 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.5 -0.1
Falls in the last year 0.0 0.0 0.0 -0.1 -0.0
Hair/balding pattern: Pattern 3 0.6 0.8 1.7 -1.3 -0.0
Number of live births 1.6 2.2 2.4 -1.5 -1.4
Forced expiratory volume in 1-second (FEV1) 3.1 10.5 20.7 4.5 0.6
Pulse rate 0.7 1.2 2.4 -1.5 0.1
Happiness 0.7 0.8 1.5 0.3 1.2
Noisy workplace 1.6 1.9 2.7 1.1 -1.7
Qualifications: A levels/AS levels or equivalent 0.7 1.5 2.8 -0.4 -1.7
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.1 1.0 1.1
Mouth/teeth dental problems: Dentures 0.2 0.3 0.4 -0.4 -0.6
Asthma 4.3 8.5 9.1 2.8 3.0
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 2.9 1.7 0.8
Medication: Cholesterol lowering 16.1 25.0 49.9 -7.1 -0.2
Depression (self-reported) 1.2 1.4 2.6 0.4 1.6
Medication: Lansoprazole 0.6 0.7 0.8 0.7 0.9
Prospective memory result 0.5 0.6 0.8 -0.9 -0.6
Lung cancer (father) 0.2 0.2 0.2 0.5 0.5
Illnesses of mother 1.3 1.7 2.9 1.7 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 4.0 12.7 25.5 5.0 0.1
Pulse wave Arterial Stiffness index 1.2 1.4 2.2 -0.7 -1.5
Impedance of arm (left) 0.9 4.0 6.1 -2.5 -1.4
Arm fat mass (right) 0.8 3.5 6.8 2.6 -0.4
Trunk predicted mass 3.3 19.1 29.7 5.5 2.9
Standing height 2.2 22.1 36.1 6.0 2.9
Length of working week for main job 0.4 0.4 0.5 0.7 -0.6
Exposure to tobacco smoke at home 1.0 1.1 1.7 -0.7 1.3
Breastfed as a baby 0.6 0.8 1.0 -1.0 0.8
Tense / ‘highly strung’ 0.6 1.0 1.4 1.2 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.0 -1.0 0.1
Hair/balding pattern: Pattern 4 0.5 1.2 1.5 -0.9 -1.2
Birth weight of first child 3.6 6.5 11.8 3.4 1.1
Peak expiratory flow (PEF) 2.5 5.9 11.6 3.4 -0.3
Pulse wave reflection index 1.8 2.2 3.1 1.8 -1.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.3 -0.4 1.1
Loud music exposure frequency 0.2 0.2 0.3 0.5 0.4
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.1 0.2 -0.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.1 -0.4 1.0
Blood clot in the leg (DVT) 1.4 1.9 3.7 -1.9 0.0
Medication: Paracetamol 2.2 3.7 7.2 2.7 0.4
Headache pain in last month 0.6 1.0 1.8 1.3 0.4
Medication for cholesterol, blood pressure or diabetes 8.0 13.2 26.3 5.1 -0.3
Glaucoma (self-reported) 0.1 0.1 0.1 -0.1 -0.4
Gout (self-reported) 0.2 0.2 0.3 0.6 0.3
Hypothyroidism/myxoedema (self-reported) 1.6 3.2 5.8 -2.4 -0.8
Medication: Amlodipine 0.6 0.9 1.0 -1.0 -0.9
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.5 0.7 0.5
Birth weight 1.5 3.2 5.6 2.4 -0.8
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.3 0.7 -1.1
High blood pressure (siblings) 1.6 2.4 2.4 -1.6 -1.5
Forced vital capacity (FVC), Best measure 3.1 11.2 19.3 4.4 1.8
Body fat percentage 0.3 1.3 1.8 0.9 -1.3
Leg fat percentage (right) 0.2 0.7 0.9 1.0 -0.8
Arm fat-free mass (right) 3.1 15.8 23.7 4.9 2.8
Exposure to tobacco smoke outside home 0.2 0.2 0.5 0.1 0.7
Comparative body size at age 10 0.2 0.6 0.7 -0.7 -0.8
Number of full brothers 0.8 1.0 1.8 0.5 -1.3
Worry too long after embarrassment 0.3 0.6 1.0 -0.5 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 1.6 -1.2 1.3
Wheeze or whistling in the chest in last year 2.0 3.6 5.3 1.4 2.3
Number of children fathered 0.0 0.0 0.1 0.0 0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.0 3.8 -1.9 0.6
Age at first live birth 0.5 0.8 1.6 -0.1 -1.3
Pulse wave peak to peak time 1.6 1.9 2.3 1.2 1.5
Health satisfaction 0.1 0.1 0.3 -0.5 -0.0
Shortness of breath walking on level ground 0.8 1.0 1.9 -0.2 1.4
Qualifications: College or University degree 1.1 3.3 4.0 -2.0 -1.6
Eye problems/disorders: None of the above 1.0 1.2 1.3 1.1 -1.0
Mouth/teeth dental problems: Loose teeth 0.0 0.1 0.1 0.1 0.3
Emphysema/chronic bronchitis 1.1 1.2 2.2 -1.5 0.4
Medication for pain relief, constipation, heartburn 0.0 0.0 0.0 -0.0 0.0
Neck or shoulder pain in last month 1.5 2.1 2.6 1.3 1.6
Medication: Blood pressure 1.4 2.5 4.7 -2.2 0.6
Angina (self-reported) 2.3 3.0 5.8 -2.4 -0.4
Migraine (self-reported) 1.7 2.1 3.2 1.8 1.0
Medication: Ibuprofen 1.4 1.6 2.9 1.7 0.6
Medication: Allopurinol 0.1 0.2 0.3 0.6 0.0
Medication: Omeprazole 0.7 0.8 1.4 -1.2 0.4
Medication: Seretide 50 evohaler 0.5 0.6 1.1 0.3 1.1
Mean time to correctly identify matches 2.4 4.6 7.4 -2.7 -1.3
Heart disease (mother) 3.5 4.3 8.6 -2.9 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.4 2.8 5.6 -2.4 0.1
Whole body fat mass 0.7 3.1 6.0 2.5 -0.4
Leg fat mass (right) 0.8 3.3 6.4 2.5 -0.3
Arm predicted mass (right) 2.5 13.0 20.6 4.5 2.3
Pulse rate, automated reading 0.5 1.5 2.8 1.7 0.3
Alcohol intake frequency. 0.3 0.8 1.2 -0.6 -1.1
Comparative height size at age 10 1.5 8.1 12.0 2.1 3.5
Number of full sisters 1.8 2.2 3.6 -0.9 1.9
Suffer from ‘nerves’ 0.1 0.2 0.2 -0.4 0.4
Overall health rating 0.4 1.0 1.9 1.4 0.2
Chest pain or discomfort 0.4 0.6 0.9 -1.0 0.4
Had major operations 0.1 0.1 0.2 0.4 -0.2
Age at last live birth 2.2 3.2 6.3 0.0 -2.5
Family relationship satisfaction 2.1 2.6 3.8 2.0 1.2
Leg pain on walking 0.5 0.6 0.7 0.8 -0.7
Qualifications: NVQ or HND or HNC or equivalent 2.9 3.5 6.4 0.8 2.5
Commuting to job workplace: Car/motor vehicle 1.0 1.1 1.8 0.7 1.3
Illness, injury, bereavement, stress in last 2 years 1.0 1.3 2.1 -1.4 -0.6
Medication: Aspirin 5.2 6.9 13.3 -3.6 -0.6
Supplements: Vitamin C 0.6 0.7 0.8 -0.7 0.9
Knee pain experienced in last month 3.7 5.8 8.8 3.0 -1.7
Hypertension (Self-reported) 1.0 2.9 5.8 -2.4 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 2.1 0.3 1.4
Illnesses of father: Heart disease 7.2 10.0 18.3 -4.3 1.3
Illnesses of siblings: Diabetes 1.5 1.9 2.0 -1.3 -1.4
Smoking status: Previous 1.5 2.2 2.5 1.6 1.4
Forced expiratory volume in 1-second (FEV1), predicted 5.3 10.9 11.2 3.3 3.3
Whole body fat-free mass 2.7 15.6 26.2 5.1 2.2
Leg fat-free mass (right) 1.7 8.9 17.0 4.1 0.9
Arm fat percentage (left) 0.4 1.8 2.8 0.9 -1.7
Average weekly red wine intake 0.2 0.4 0.6 -0.8 -0.3
Handedness (chirality/laterality): Left-handed 2.2 2.6 4.6 -0.8 -2.1
Mood swings 0.3 0.5 0.8 0.3 0.9
Loneliness, isolation 0.4 0.6 1.2 1.1 -0.2
Long-standing illness, disability or infirmity 1.8 2.7 2.9 -1.7 1.6
Ever had bowel cancer screening 0.4 0.5 0.7 -0.5 -0.8
Diabetes diagnosed by doctor 0.3 0.4 0.6 -0.6 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.5 -1.2 -0.3
Friendships satisfaction 0.8 1.0 1.3 1.1 0.8
Qualifications: nursing, teaching 1.0 1.6 2.7 0.7 -1.6
Commuting to job workplace: Walk 2.3 2.5 3.0 -1.7 -1.4
Eye problems/disorders: Cataract 2.0 2.4 4.0 -2.0 0.8
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 2.7 1.7 -1.3
Medication for cholesterol 3.1 4.6 8.9 3.0 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.3 0.6 -0.3
Back pain experienced in last month 0.5 0.7 1.3 0.2 1.2
Mineral and other dietary supplements 1.1 1.5 2.9 -0.2 -1.7
Breast cancer (self-reported) 1.7 2.1 3.9 -2.0 -0.4
Asthma (self-reported) 3.6 7.2 9.4 2.3 3.1
Osteoporosis (self-reported) 0.9 1.1 1.4 0.9 -1.2
Osteoarthritis (self-reported) 2.2 2.9 3.5 1.5 1.9
Medication: Aspirin 6.1 7.9 15.8 -4.0 -0.3
Medication: Gliclazide 0.2 0.2 0.5 -0.7 -0.1
Illnesses of father: None of the above (group 1) 4.0 4.9 9.1 3.0 -0.8
Smoking status: Current 0.2 0.4 0.4 0.5 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.1 4.5 8.7 3.0 -0.5
Whole body water mass 2.7 15.3 25.2 5.0 2.3
Leg predicted mass (right) 1.7 9.2 17.5 4.2 0.9
Arm fat mass (left) 0.8 3.1 6.0 2.4 -0.6
Number of self-reported non-cancer illnesses 1.7 3.0 3.8 -2.0 1.5
Average weekly champagne plus white wine intake 1.2 1.6 1.8 -1.2 -1.4
Miserableness 0.0 0.0 0.0 0.1 -0.1
Guilty feelings 0.0 0.1 0.1 -0.1 0.3
Wears glasses or contact lenses 0.6 0.7 1.3 -1.2 0.1
Ever taken oral contraceptive pill 0.6 0.7 1.2 1.1 0.4
Hearing aid user 3.7 4.2 8.3 0.4 2.9
Mother’s age at death 0.7 0.8 1.6 0.3 -1.2
Financial situation satisfaction 2.0 2.5 3.3 1.8 1.3
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.1 0.7 -1.0
Commuting to job workplace: Public transport 0.1 0.1 0.1 -0.1 0.3
Eye problems/disorders: Glaucoma 0.8 1.0 1.8 -1.3 -0.4
Medication: Blood pressure 1.0 1.9 3.0 -1.7 -0.9
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.1 0.4 0.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.5 -0.3 1.2
High cholesterol (Self-reported) 35.4 62.8 125.4 -11.2 -0.4
Medication: Bendroflumethiazide 0.4 0.5 0.6 -0.7 -0.8
Medication: Paracetamol 2.2 3.4 6.5 2.5 0.5
Medication: Lisinopril 1.2 1.5 1.6 -1.2 1.3
Medication: Atorvastatin 15.7 19.4 35.8 -6.0 -1.8
Illnesses of father: High blood pressure 0.6 0.8 1.0 -0.8 1.0
Alcohol drinker status: Never 0.2 0.3 0.3 -0.5 -0.5
Ever smoked 3.0 5.2 8.1 1.5 2.8
Basal metabolic rate 2.5 14.0 24.7 5.0 1.8
Leg fat percentage (left) 0.1 0.5 0.7 0.5 -0.9
Arm fat-free mass (left) 2.9 14.7 23.0 4.8 2.5
Number of operations (self-reported) 0.6 0.9 1.7 -0.4 1.3
Average weekly beer plus cider intake 0.9 1.2 2.3 1.5 0.5
Irritability 1.2 2.0 3.2 0.9 1.8
Risk taking 2.6 3.9 6.1 -1.3 2.5
Ever had prostate specific antigen (PSA) test 1.1 1.2 1.6 -1.3 0.9
Fractured/broken bones in last 5 years 1.0 1.3 2.1 1.4 0.7
Age started oral contraceptive pill 1.2 1.5 2.9 0.3 -1.7
Diastolic blood pressure, automated reading 0.1 0.4 0.8 0.0 -0.9
Ever depressed for a whole week 2.4 3.0 4.5 -2.1 1.2
Unable to work because of sickness or disability 0.2 0.3 0.6 0.2 0.7
Commuting to job workplace: Cycle 0.4 0.4 0.9 0.1 -0.9
Myopia 0.4 0.6 1.1 0.2 1.1
Vascular/heart problems diagnosed by doctor 1.6 4.4 8.8 3.0 -0.1
Cholesterol lowering medication 21.5 31.6 62.9 -7.9 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.4 -0.7 0.3
Pain experienced in last month 2.9 4.8 7.1 -2.7 -1.6
Supplements: Calcium 1.2 1.3 2.3 -0.5 1.5
Basal cell carcinoma (self-reported) 0.7 0.8 0.9 -1.0 -0.8
Heart attack/myocardial infarction (self-reported) 2.0 2.6 4.9 -2.2 0.5
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.2 -1.1 0.3
Heart disease (siblings) 3.7 4.6 8.9 -3.0 -0.4
Alcohol drinker status: Previous 1.2 1.4 2.4 -1.6 -0.5
Pack years of smoking 0.1 0.1 0.2 -0.2 -0.5
Impedance of whole body 0.4 2.1 3.8 -1.9 -0.7
Leg fat mass (left) 0.7 2.6 5.2 2.3 -0.3
Arm predicted mass (left) 3.1 15.7 25.8 5.1 2.4