TWAS hub - LDLR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.619	0.132	0.0010	0.002	NA	-0.010	NA	0.001	0.28	NA	0.710	NA	0.29
2	GTEx	Pancreas	0.187	0.084	0.0090	-0.007	NA	0.012	NA	0.006	0.84	NA	0.097	NA	0.18
3	GTEx	Prostate	0.411	0.138	0.0091	-0.012	NA	0.003	NA	-0.009	0.94	NA	0.270	NA	0.62

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
High cholesterol (Self-reported)	14.1	25.1	74.6	-0.7	-8.6
LDL Cholesterol	12.5	19.8	59.3	-0.4	-7.7
Medication: Cholesterol lowering	10.6	16.4	45.6	-1.9	-6.8
Medication: Simvastatin	9.7	14.2	39.1	-1.9	-6.2
Cholesterol lowering medication	4.8	7.0	21.1	0.0	-4.6
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.8	7.1	2.7	2.1
Medication for cholesterol	3.2	4.9	14.6	0.2	3.8
Medication for cholesterol, blood pressure or diabetes	2.8	4.7	13.2	0.9	3.6
Medication: Aspirin	2.7	3.5	9.8	-0.8	-3.1
Number of treatments/medications taken	2.6	4.7	13.8	-0.6	-3.7
Eye problems/disorders: None of the above	2.6	3.0	8.7	0.4	3.0
Hearing aid user	2.6	2.9	8.1	0.8	-2.9
Ever taken oral contraceptive pill	2.5	2.7	5.4	1.7	2.3
Loud music exposure frequency	2.4	2.7	7.5	0.7	2.7
Eye problems/disorders: Cataract	2.4	2.8	7.0	-1.2	-2.6
Mouth/teeth dental problems	2.3	3.6	8.5	2.9	-1.5
Medication: Aspirin	2.3	3.1	8.2	-1.0	-2.9
Long-standing illness, disability or infirmity	2.3	3.5	7.2	1.9	-2.7
Angina	2.1	2.7	6.6	-1.3	-2.6
Relative age voice broke	2.1	3.2	7.9	-1.2	2.8
Number of self-reported non-cancer illnesses	2.0	3.4	9.1	1.1	-3.0
Medication: Ramipril	1.9	2.4	6.4	-1.0	-2.5
Medication for pain relief, constipation, heartburn	1.9	3.2	6.2	2.5	1.9
Angina (self-reported)	1.9	2.6	6.2	-1.2	-2.5
Suffer from ‘nerves’	1.9	3.0	5.6	1.8	2.4
Medication: Atorvastatin	1.9	2.3	6.3	0.8	-2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	7.8	-0.6	2.8
Heart disease (mother)	1.8	2.2	5.5	2.4	-1.0
Guilty feelings	1.8	2.8	4.7	1.9	2.2
Schizophrenia vs Biploar Disorder	1.7	2.2	5.0	-2.2	1.3
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	6.5	-0.2	-2.5
Severe depression (siblings)	1.7	1.9	4.1	2.0	1.2
Ever had bowel cancer screening	1.7	2.0	5.5	-0.6	-2.3
Primary Biliary Cirrhosis	1.6	2.3	3.7	1.9	-1.8
Tinnitus: Yes, now most or all of the time	1.6	1.9	5.3	-0.6	-2.3
Pack years of smoking	1.6	2.3	6.3	-2.5	0.8
Glaucoma (self-reported)	1.5	1.8	3.3	1.8	-1.4
Eye problems/disorders: Glaucoma	1.5	1.7	4.5	0.8	-2.1
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.3	-1.8	-1.6
Chronotype (morning person)	1.4	3.2	8.4	2.9	-1.1
Diabetes (father)	1.4	1.8	5.2	0.3	2.3
Pack years adult smoking proportion	1.4	2.1	5.7	-2.4	0.8
Mouth/teeth dental problems: Dentures	1.4	2.4	5.2	-2.3	1.4
Blood clot in the leg (DVT)	1.4	1.8	4.5	1.0	-2.1
Number of full brothers	1.4	1.8	4.6	-0.9	2.1
Qualifications: CSEs or equivalent	1.3	1.8	3.4	1.4	1.8
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	4.2	0.7	2.0
High blood pressure (siblings)	1.3	1.8	4.3	1.0	-2.1
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	4.2	0.8	-2.1
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.8	2.0	1.2
Pulse rate	1.2	2.1	3.8	-1.6	-1.9
Breastfed as a baby	1.2	1.5	4.2	-2.1	0.4
Family relationship satisfaction	1.2	1.5	4.3	-0.3	2.1
Taking other prescription medications	1.1	1.6	4.9	-0.2	-2.2
Pulse wave reflection index	1.1	1.3	2.5	1.2	1.6
Smoking status: Previous	1.1	1.6	3.8	1.0	1.9
Wears glasses or contact lenses	1.1	1.3	3.8	-0.0	-1.9
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.8	1.0	-1.7
Type 2 Diabetes (T2D) (2012)	1.0	1.1	3.3	-1.8	0.2
Relative age of first facial hair	1.0	2.1	6.2	-0.4	2.5
Age at last live birth	1.0	1.4	2.6	-1.6	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	3.4	1.8	-0.0
Diastolic blood pressure, automated reading	1.0	3.0	8.9	-0.3	3.0
Heart disease (siblings)	1.0	1.2	3.3	1.8	-0.6
Bipolar Disorder (2018)	0.9	1.5	3.3	1.8	-1.1
Cardiovascular Disease	0.9	3.0	9.1	-0.0	-3.0
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.3	-1.8	0.2
Illnesses of mother	0.9	1.1	2.5	-1.6	-0.8
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.7	1.9	-0.7
Birth weight	0.9	2.0	5.9	-2.4	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.2	0.8	-1.5
Asthma (self-reported)	0.9	1.8	4.5	0.9	-2.1
Medication: Paracetamol	0.9	1.3	3.8	-1.9	-0.5
Risk taking	0.9	1.3	3.3	1.8	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.2	-0.5	-1.8
Prostate Cancer	0.8	1.1	2.0	-1.4	1.2
Rheumatoid Arthritis	0.8	1.1	1.8	1.2	-1.3
Qualifications: None of the above	0.8	1.8	5.2	-2.3	-0.2
Alcohol intake versus 10 years previously	0.8	1.1	1.9	1.4	1.2
Asthma	0.8	1.5	4.0	0.8	-2.0
Length of working week for main job	0.8	0.8	1.3	-1.1	1.1
Emphysema/chronic bronchitis	0.8	0.9	2.1	-1.4	-0.8
Illnesses of father: None of the above (group 1)	0.8	1.0	1.9	1.1	1.4
Illnesses of father: High blood pressure	0.8	0.9	1.6	1.3	-1.1
Supplements: Calcium	0.8	0.9	2.4	1.5	-0.5
Major Depression (MDD)	0.7	0.8	2.3	1.5	-0.4
Neuroticism	0.7	1.6	4.5	-0.6	2.1
Multivitamins +/- minerals	0.7	0.9	2.7	0.2	1.6
Nervous feelings	0.7	1.2	3.6	0.2	1.9
Neuroticism score	0.7	1.4	3.7	-0.8	1.9
Medication: Paracetamol	0.7	1.2	3.5	-1.9	-0.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.6	0.2	-1.6
Illnesses of father: Heart disease	0.7	1.0	2.9	0.2	-1.7
Back pain experienced in last month	0.7	1.0	1.8	-1.0	-1.4
Osteoporosis (self-reported)	0.7	0.8	2.3	-1.5	0.3
Medication: Bendroflumethiazide	0.7	1.0	1.7	-1.1	-1.3
Leg fat percentage (left)	0.7	2.5	4.8	-1.6	2.2
Depressed Affect (Nagel 2018)	0.6	1.3	2.6	-1.6	1.2
Coronary Artery Disease (CAD)	0.6	0.7	1.3	0.9	-1.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.0	-0.1	-1.4
Fed-up feelings	0.6	1.0	3.1	-1.8	0.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.9	0.0	1.4
Past tobacco smoking	0.6	1.1	1.8	-1.2	-1.3
Allergy	0.6	1.4	3.6	-0.9	1.9
Noisy workplace	0.6	0.7	2.2	-0.2	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.2	0.9	1.1
Exposure to tobacco smoke at home	0.6	0.7	1.2	1.0	-1.1
Tense / ‘highly strung’	0.6	0.9	2.7	-0.3	1.6
Neck or shoulder pain in last month	0.6	0.8	1.8	1.4	-0.8
Medication: Omeprazole	0.6	0.7	2.1	0.2	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.1	-0.2	1.5
Loneliness, isolation	0.6	0.9	1.9	-0.8	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.7	-1.3	-0.6
Crohns Disease (2012)	0.5	0.8	1.6	1.3	-0.9
Fasting Glucose	0.5	0.6	1.4	-1.2	-0.7
BMI	0.5	2.8	8.4	-0.2	2.9
Sensitivity / hurt feelings	0.5	0.9	1.8	-1.4	1.0
Medication for hormone replacement therapy	0.5	0.6	1.3	-0.6	-1.1
Medication: Metformin	0.5	0.7	1.3	-0.9	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.9	0.5	1.4
Had menopause	0.5	0.6	1.7	-1.3	0.2
Heart attack	0.5	0.6	1.9	-0.2	-1.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.0	1.4	-0.2
Depression (self-reported)	0.5	0.5	1.6	-1.3	0.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.1	-0.7	1.1
Headache pain in last month	0.5	0.9	2.2	0.6	-1.5
Leg fat percentage (right)	0.5	1.9	3.7	-1.4	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	1.3	-0.2
Shortness of breath walking on level ground	0.5	0.5	1.6	0.2	-1.3
Leg fat mass (right)	0.5	1.8	4.1	-1.1	2.0
Leg pain on walking	0.5	0.7	1.2	-1.1	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.2	-1.0	1.1
Breast cancer (self-reported)	0.5	0.5	0.8	0.9	-0.9
Average weekly champagne plus white wine intake	0.5	0.7	2.2	0.2	-1.5
Fractured/broken bones in last 5 years	0.5	0.7	1.7	0.5	1.3
Leg fat mass (left)	0.5	1.9	4.4	-1.2	2.1
Alzheimer’s Disease (in father)	0.4	0.4	0.7	-0.8	-0.7
Alzheimer’s Disease (including proxy)	0.4	0.6	1.4	-1.2	-0.7
Ovarian Cancer	0.4	0.5	1.5	-0.4	1.2
Respiratory disease	0.4	1.0	2.1	0.9	-1.4
Average weekly spirits intake	0.4	0.5	1.5	-1.2	-0.2
Body mass index (BMI)	0.4	1.8	5.4	-0.3	2.3
Alcohol usually taken with meals	0.4	0.7	1.0	1.0	-1.0
Pain all over the body in last month	0.4	0.4	1.2	0.2	1.1
Illnesses of siblings	0.4	0.6	1.7	-0.5	1.3
Father’s age at death	0.4	0.6	1.4	1.2	0.5
Number of live births	0.4	0.5	1.3	-1.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	0.4	1.1
Prospective memory result	0.4	0.5	1.2	-0.5	-1.1
Arm fat mass (right)	0.4	1.5	3.9	-0.7	2.0
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.7	0.9	0.7
Body fat percentage	0.4	1.4	2.5	-1.4	1.6
Wheeze or whistling in the chest in last year	0.4	0.7	1.4	1.2	-0.9
Number of children fathered	0.4	0.4	0.7	-0.8	-0.9
Pulse wave peak to peak time	0.4	0.4	0.8	0.7	-0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.4	0.1	1.2
Medication: Blood pressure	0.4	0.8	1.8	-0.7	-1.4
Migraine (self-reported)	0.4	0.6	1.6	1.3	0.3
Medication: Ibuprofen	0.4	0.5	1.3	-0.3	1.2
Medication: Seretide 50 evohaler	0.4	0.4	1.2	1.1	0.0
Mean time to correctly identify matches	0.4	0.7	1.3	0.9	-1.1
Illnesses of siblings: Diabetes	0.4	0.5	1.4	0.1	1.2
Friendships satisfaction	0.4	0.5	0.9	-0.9	0.9
Arm fat mass (left)	0.4	1.5	3.8	-0.8	1.9
Commuting to job workplace: Public transport	0.4	0.5	1.5	0.1	1.2
Average weekly beer plus cider intake	0.4	0.5	1.1	-1.0	0.7
Ever depressed for a whole week	0.4	0.5	1.1	0.7	1.0
Myopia	0.4	0.6	1.0	1.0	-0.8
Basal cell carcinoma (self-reported)	0.4	0.5	1.4	-1.2	-0.0
Schizophrenia (2018)	0.3	0.7	1.2	1.1	0.9
Crohns Disease (2017)	0.3	0.6	1.5	-0.4	-1.2
Breast Cancer	0.3	0.7	1.7	-0.6	1.3
Mean Putamen Volume	0.3	0.3	0.5	0.7	-0.7
Smoking Status	0.3	0.7	1.3	-1.2	0.9
Hypothyroidism (self reported)	0.3	0.7	1.1	-1.1	-1.0
Supplements: Zinc	0.3	0.3	0.4	0.6	0.6
Townsend deprivation index at recruitment	0.3	0.4	1.1	-1.0	0.0
Current tobacco smoking	0.3	0.4	1.0	-1.0	-0.5
Average weekly fortified wine intake	0.3	0.3	0.8	0.9	-0.4
Age when periods started (menarche)	0.3	0.7	2.0	-0.4	1.4
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	-0.9	0.4
Impedance of leg (left)	0.3	1.5	3.8	-2.0	-0.8
Trunk fat mass	0.3	1.4	2.2	-1.5	1.4
Waist circumference	0.3	0.9	2.1	-0.8	1.4
Weight	0.3	1.4	3.4	-0.9	1.8
Hip circumference	0.3	1.5	4.2	-0.6	2.0
Falls in the last year	0.3	0.4	1.2	0.1	1.1
Medication: Lansoprazole	0.3	0.4	0.7	0.9	-0.7
Impedance of arm (left)	0.3	1.3	3.9	0.1	-2.0
Peak expiratory flow (PEF)	0.3	0.8	2.1	0.5	1.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.0	-0.1	1.0
Exposure to tobacco smoke outside home	0.3	0.4	1.1	0.2	1.0
Comparative body size at age 10	0.3	0.8	1.7	-0.8	1.3
Health satisfaction	0.3	0.3	1.0	-1.0	0.1
Whole body fat mass	0.3	1.3	2.3	-1.3	1.5
Alcohol intake frequency.	0.3	0.7	1.9	-0.4	1.4
Arm fat percentage (left)	0.3	1.1	3.1	-0.3	1.8
Mood swings	0.3	0.5	1.3	-1.2	0.4
Mineral and other dietary supplements	0.3	0.3	1.0	-1.0	0.1
Osteoarthritis (self-reported)	0.3	0.4	1.1	0.3	-1.0
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.3	1.1	0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	-0.1	-1.1
Impedance of whole body	0.3	1.3	2.5	-1.2	-1.6
Arm predicted mass (left)	0.3	1.3	2.4	-1.2	1.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.6	-1.3	-0.1
Neuroticism (Nagel 2018)	0.2	0.5	1.3	-0.5	1.1
Worry (Nagel 2018)	0.2	0.5	1.2	0.6	1.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.6	-0.6
Irritable Bowel Disease (IBD)	0.2	0.5	0.8	-0.8	-0.9
Ulcerative Colitis (UC)	0.2	0.3	1.0	-1.0	0.0
HbA1C	0.2	0.2	0.4	0.4	0.6
HDL Cholesterol	0.2	0.3	0.8	-0.9	-0.1
Lupus	0.2	0.3	0.7	0.8	-0.6
Neuroticism (2016)	0.2	0.2	0.6	-0.8	-0.2
Blood White Count	0.2	1.2	3.4	-0.2	-1.9
Height	0.2	3.6	8.6	-2.9	-1.4
Lung FEV1/FVC ratio	0.2	1.1	3.0	-0.5	1.7
Lung FVC	0.2	1.0	2.5	1.6	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.6	0.4	0.8
Ever had hysterectomy (womb removed)	0.2	0.3	0.4	0.6	0.7
Systolic blood pressure, automated reading	0.2	0.6	0.9	-1.0	-1.0
Medication: Co-codamol	0.2	0.2	0.5	0.2	-0.7
Diabetes (mother)	0.2	0.3	0.8	0.1	0.9
Impedance of leg (right)	0.2	1.2	2.2	-1.5	-1.2
Leg fat-free mass (left)	0.2	0.9	2.6	0.1	1.6
Trunk fat percentage	0.2	1.0	1.8	-1.3	1.1
Serious illness, injury or assault to yourself	0.2	0.2	0.6	-0.0	-0.8
Stomach or abdominal pain in last month	0.2	0.3	0.8	-0.2	0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	-0.9	0.2
High blood pressure (mother)	0.2	0.3	0.6	0.4	0.8
Leg predicted mass (left)	0.2	0.9	2.8	0.1	1.7
Impedance of arm (right)	0.2	0.8	2.4	0.3	-1.6
Arm fat percentage (right)	0.2	0.9	2.6	-0.3	1.6
Worrier / anxious feelings	0.2	0.3	0.9	-0.9	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.9	-0.3	-0.9
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.9	0.9	-0.1
Medication: Amlodipine	0.2	0.2	0.4	-0.6	-0.6
Arm fat-free mass (right)	0.2	0.9	2.3	-0.6	1.5
Worry too long after embarrassment	0.2	0.3	0.9	-1.0	0.2
Medication: Allopurinol	0.2	0.2	0.6	-0.4	-0.8
Arm predicted mass (right)	0.2	1.0	1.9	-1.0	1.4
Pulse rate, automated reading	0.2	0.7	1.8	0.6	-1.3
Overall health rating	0.2	0.4	0.8	-0.7	-0.9
Supplements: Vitamin C	0.2	0.2	0.4	0.7	0.5
Leg fat-free mass (right)	0.2	1.1	3.2	-0.1	1.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	-0.6	0.6
Diabetes diagnosed by doctor	0.2	0.4	0.6	-0.8	-0.7
Qualifications: nursing, teaching	0.2	0.3	0.7	0.8	-0.5
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.2	-0.7
Medication: Gliclazide	0.2	0.2	0.7	-0.8	-0.2
Smoking status: Current	0.2	0.4	0.9	-0.9	-0.4
Leg predicted mass (right)	0.2	1.1	3.3	-0.0	1.8
Medication: Blood pressure	0.2	0.5	1.2	-0.5	-1.1
Ever smoked	0.2	0.4	0.9	0.9	0.5
Basal metabolic rate	0.2	1.0	2.8	-0.6	1.7
Arm fat-free mass (left)	0.2	1.3	2.7	-1.0	1.7
Irritability	0.2	0.3	0.5	0.7	-0.5
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.5	0.8
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.7	-0.6
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.6	0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.7	0.8	-0.1
Depression (Nagel 2018)	0.1	0.1	0.3	0.3	0.6
Reaction Time	0.1	0.2	0.7	0.8	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.9	-0.4	0.9
Age at First Birth	0.1	0.1	0.2	-0.5	0.2
Schizophrenia (2014)	0.1	0.2	0.3	0.5	0.5
Ulcerative Colitis	0.1	0.1	0.3	0.3	-0.5
Blood Platelet Count	0.1	1.2	2.8	1.7	-1.0
Blood Red Count	0.1	0.6	1.3	0.6	1.1
Waist Hip Ratio (WHR)	0.1	0.7	1.6	-1.2	-0.7
Systolic Blood Pressure	0.1	0.3	0.5	0.6	-0.7
Hair Pigment	0.1	3.0	8.4	0.7	-2.9
Hand grip strength (left)	0.1	0.2	0.7	-0.1	-0.8
Vitamin and mineral supplements	0.1	0.1	0.2	-0.3	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.4	0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.8	-0.1
High blood pressure	0.1	0.4	0.7	-0.8	-0.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.7	-0.5
Supplements: Glucosamine	0.1	0.2	0.4	0.1	-0.7
Number of incorrect matches in round	0.1	0.1	0.2	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	0.5	0.3
Financial difficulties in last 2 years	0.1	0.2	0.5	0.7	0.3
Diabetes (self-reported)	0.1	0.1	0.3	-0.3	-0.6
Trunk fat-free mass	0.1	0.5	1.0	-0.6	1.0
Time employed in main current job	0.1	0.1	0.3	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.6	-0.2	0.8
Happiness	0.1	0.1	0.2	0.3	0.5
Lung cancer (father)	0.1	0.1	0.2	-0.1	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	-0.6	0.8
Trunk predicted mass	0.1	0.5	1.1	-0.6	1.0
Standing height	0.1	1.3	3.4	-1.8	-0.7
Gout (self-reported)	0.1	0.2	0.4	-0.6	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	-0.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.1	-0.6
Age at first live birth	0.1	0.1	0.4	0.0	0.6
Comparative height size at age 10	0.1	0.3	0.6	-0.6	-0.8
Chest pain or discomfort	0.1	0.2	0.6	-0.7	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	-0.3	-0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.0	-0.5
Knee pain experienced in last month	0.1	0.1	0.3	-0.6	-0.2
Hypertension (Self-reported)	0.1	0.2	0.5	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.7	0.5
Whole body fat-free mass	0.1	0.7	1.8	-0.5	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.4	0.0	-0.7
Whole body water mass	0.1	0.6	1.6	-0.4	1.3
Mother’s age at death	0.1	0.1	0.2	0.3	-0.4
Financial situation satisfaction	0.1	0.1	0.4	0.6	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.6	-0.3
Alcohol drinker status: Never	0.1	0.2	0.4	-0.6	-0.4
Pain experienced in last month	0.1	0.2	0.3	0.4	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	0.2	0.3
Triglycerides	0.0	0.0	0.0	0.0	-0.2
Blood Eosinophil Count	0.0	0.0	0.1	-0.3	0.0
Heel T-Score	0.0	0.3	0.9	-0.2	-0.9
Allergy or Eczema	0.0	0.0	0.0	0.2	-0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	-0.0	-0.4
Tanning	0.0	0.5	1.5	-0.3	-1.2
Hearing difficulty/problems: Yes	0.0	0.1	0.2	-0.1	0.4
Hand grip strength (right)	0.0	0.0	0.1	-0.3	0.2
Maternal smoking around birth	0.0	0.0	0.0	0.1	0.2
Medication: Atenolol	0.0	0.0	0.0	-0.1	-0.2
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.1	0.3
Sitting height	0.0	0.1	0.3	-0.3	-0.5
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.4	0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	0.1	-0.3
Had other major operations	0.0	0.0	0.1	0.1	0.2
Forced vital capacity (FVC)	0.0	0.1	0.2	0.5	-0.1
Fluid intelligence score	0.0	0.0	0.1	0.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	-0.3	0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	0.2	0.4
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	-0.2	0.1
Birth weight of first child	0.0	0.1	0.2	-0.4	0.0
Forced vital capacity (FVC), Best measure	0.0	0.0	0.1	-0.0	-0.4
Qualifications: College or University degree	0.0	0.0	0.1	0.3	0.1
Number of full sisters	0.0	0.0	0.1	-0.2	-0.2
Had major operations	0.0	0.0	0.1	-0.2	0.2
Average weekly red wine intake	0.0	0.1	0.1	-0.2	-0.3
Miserableness	0.0	0.0	0.1	0.0	0.3
Medication: Lisinopril	0.0	0.1	0.1	-0.2	0.3
Number of operations (self-reported)	0.0	0.0	0.1	-0.3	-0.1
Age started oral contraceptive pill	0.0	0.0	0.1	-0.1	0.3

Hub : Genes

LDLR

Models

Trait associations