Best TWAS P=3.67e-14 · Best GWAS P=4.15e-19 conditioned to 0.000637
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RAD9A | 0.43 | 0.22 | lasso | 6 | 0.23 | 7.1e-19 | -6.5 | -6.4 | 1.7e-10 | 0.01 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Aorta | C11orf24 | 0.29 | 0.17 | lasso | 4 | 0.15 | 7.7e-09 | -5.4 | 5.2 | 2.0e-07 | -0.07 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | C11orf24 | 0.13 | 0.08 | lasso | 3 | 0.06 | 1.5e-05 | -5.5 | 5.8 | 5.2e-09 | -0.07 | 0.85 | 0.01 | TRUE |
| 4 | GTEx | Artery Tibial | RAD9A | 0.39 | 0.26 | lasso | 2 | 0.24 | 3.5e-19 | -6.5 | -6.5 | 6.0e-11 | 0.03 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Brain Cerebellum | MRGPRF | 0.17 | 0.19 | lasso | 4 | 0.14 | 5.1e-05 | -6.1 | -6.1 | 9.4e-10 | 0.51 | 0.13 | 0.34 | FALSE |
| 6 | GTEx | Colon Sigmoid | C11orf24 | 0.46 | 0.17 | enet | 37 | 0.25 | 3.3e-09 | -5.4 | 5.5 | 3.5e-08 | -0.11 | 0.71 | 0.02 | FALSE |
| 7 | GTEx | Colon Transverse | RAD9A | 0.40 | 0.16 | lasso | 8 | 0.16 | 7.2e-08 | -6.5 | -5.2 | 2.5e-07 | 0.01 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Esophagus Muscularis | TCIRG1 | 0.10 | 0.09 | lasso | 2 | 0.06 | 8.7e-05 | -2.7 | 5.2 | 2.4e-07 | -0.31 | 0.20 | 0.07 | FALSE |
| 9 | GTEx | Esophagus Muscularis | IGHMBP2 | 0.12 | 0.06 | enet | 17 | 0.06 | 9.4e-05 | 2.9 | 5.6 | 2.0e-08 | -0.33 | 0.62 | 0.29 | TRUE |
| 10 | GTEx | Esophagus Muscularis | C11orf24 | 0.10 | 0.10 | lasso | 1 | 0.08 | 1.5e-05 | -5.5 | 5.5 | 3.2e-08 | -0.06 | 0.82 | 0.01 | FALSE |
| 11 | GTEx | Esophagus Muscularis | RAD9A | 0.25 | 0.26 | lasso | 2 | 0.26 | 6.2e-16 | -6.5 | -6.5 | 5.6e-11 | 0.04 | 0.00 | 1.00 | TRUE |
| 12 | GTEx | Esophagus Muscularis | MRGPRF | 0.09 | 0.01 | lasso | 3 | 0.01 | 1.3e-01 | -6.9 | 7.5 | 8.4e-14 | -0.62 | 0.02 | 0.84 | FALSE |
| 13 | GTEx | Heart Atrial Appendage | C11orf24 | 0.23 | 0.18 | lasso | 8 | 0.16 | 8.7e-08 | -5.5 | 5.2 | 2.5e-07 | -0.03 | 0.95 | 0.00 | FALSE |
| 14 | GTEx | Heart Left Ventricle | C11orf24 | 0.21 | 0.21 | lasso | 2 | 0.20 | 4.8e-11 | -5.4 | 5.4 | 7.0e-08 | -0.06 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Nerve Tibial | C11orf24 | 0.67 | 0.65 | enet | 7 | 0.65 | 6.9e-60 | -5.5 | 5.2 | 1.6e-07 | -0.07 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Nerve Tibial | RAD9A | 0.53 | 0.24 | lasso | 10 | 0.23 | 5.6e-16 | -6.5 | -6.2 | 4.5e-10 | 0.03 | 0.00 | 1.00 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | LRP5 | 0.13 | 0.05 | lasso | 5 | 0.07 | 1.2e-06 | -6.5 | -6.6 | 3.6e-11 | 0.30 | 0.78 | 0.02 | FALSE |
| 18 | GTEx | Testis | RAD9A | 0.72 | 0.50 | lasso | 4 | 0.49 | 1.1e-24 | -6.5 | -6.4 | 1.7e-10 | 0.03 | 0.00 | 1.00 | FALSE |
| 19 | ROSMAP | Brain Pre-frontal Cortex | GAL | 0.21 | 0.17 | bslmm | 393 | 0.17 | 1.5e-21 | -5.3 | -5.7 | 1.3e-08 | 0.55 | 1.00 | 0.00 | FALSE |
| 20 | ROSMAP | Brain Pre-frontal Cortex | PPP6R3 | 0.04 | 0.01 | blup | 421 | 0.02 | 3.2e-04 | -6.4 | 7.6 | 3.7e-14 | -0.73 | 0.22 | 0.76 | TRUE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | RAD9A | 0.34 | 0.17 | enet | 21 | 0.20 | 1.1e-25 | -6.5 | -5.4 | 8.4e-08 | 0.04 | 0.00 | 1.00 | FALSE |
| 22 | YFS | Blood | MTL5 | 0.05 | 0.03 | blup | 422 | 0.03 | 2.1e-11 | -3.2 | 6.4 | 1.7e-10 | -0.45 | 1.00 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SAPS3 | 0.04 | 0.02 | blup | 84 | 0.04 | 2.5e-05 | -5.7 | 7.5 | 4.8e-14 | -0.79 | 0.23 | 0.76 | FALSE |