TWAS hub - LRP5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.247	0.0918	0.00210	0.136	NA	0.045	NA	0.064	1.4e-05	NA	0.00990	NA	2.5e-03
2	GTEx	Skin Sun Exposed Lower leg	0.127	0.0480	0.00063	0.054	NA	0.039	NA	0.073	2.8e-05	NA	0.00034	NA	1.2e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Impedance of leg (left)	7.3	35.5	37.2	6.1	5.8
Impedance of leg (right)	7.1	34.2	36.4	6.0	5.7
Leg fat-free mass (right)	6.3	33.8	44.0	-4.9	-6.6
Leg predicted mass (right)	6.3	33.6	43.7	-4.8	-6.6
Leg fat-free mass (left)	5.9	31.1	41.4	-4.6	-6.4
Leg predicted mass (left)	5.9	31.1	41.4	-4.6	-6.4
Financial difficulties in last 2 years	5.8	7.7	11.8	3.4	1.9
Basal cell carcinoma (self-reported)	5.8	6.9	8.3	-2.4	-2.9
Rheumatoid Arthritis	5.7	7.9	11.1	-2.2	-3.3
Whole body fat-free mass	5.5	31.2	41.9	-4.5	-6.5
Whole body water mass	5.4	30.7	41.1	-4.5	-6.4
Arm fat-free mass (right)	5.0	25.6	33.2	-4.2	-5.8
Trunk predicted mass	4.9	27.9	38.6	-4.2	-6.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.8	10.1	10.2	-3.2	-3.2
Basal metabolic rate	4.8	26.8	36.2	-4.2	-6.0
Trunk fat-free mass	4.7	27.1	37.5	-4.1	-6.1
Arm fat-free mass (left)	4.6	23.4	30.1	-4.1	-5.5
Sitting height	4.5	32.0	43.8	-4.5	-6.6
Alcohol usually taken with meals	4.5	7.3	8.9	-3.0	-2.4
Arm predicted mass (right)	4.5	22.8	30.5	-3.9	-5.5
Arm predicted mass (left)	4.4	22.2	28.5	-4.0	-5.3
Waist Hip Ratio (WHR)	4.3	19.3	28.2	5.3	3.2
Alcohol intake versus 10 years previously	3.9	5.8	6.9	2.2	2.6
Wears glasses or contact lenses	3.9	4.5	6.3	-2.5	-1.7
Fasting Glucose	3.8	4.6	6.3	-2.5	-1.7
Weight	3.8	18.6	24.4	-3.6	-4.9
Birth weight of first child	3.8	7.0	7.7	-2.5	-2.8
Systolic Blood Pressure	3.7	18.5	23.1	3.7	4.8
Happiness	3.6	4.4	4.6	-2.1	-2.0
Number of treatments/medications taken	3.5	6.2	7.8	2.2	2.8
Medication: Ibuprofen (e.g. Nurofen)	3.2	4.1	6.3	2.5	1.4
Hearing difficulty/problems with background noise	3.1	5.0	6.7	-2.6	-1.8
Health satisfaction	3.1	4.0	4.4	-1.9	-2.1
Bipolar Disorder (2011)	3.0	2.9	3.3	1.6	1.8
Impedance of whole body	3.0	15.2	17.8	4.2	3.6
Bipolar Disorder (2018)	2.9	4.6	5.0	2.0	2.2
Worrier / anxious feelings	2.8	5.4	6.4	2.1	2.5
Shortness of breath walking on level ground	2.8	3.3	3.7	-1.7	-1.9
Hip circumference	2.7	11.6	13.1	-3.2	-3.6
Breastfed as a baby	2.7	3.3	3.4	-1.9	-1.8
Family relationship satisfaction	2.7	3.3	3.6	-1.7	-1.9
Standing height	2.5	24.9	43.0	-2.6	-6.6
Mouth/teeth dental problems: Loose teeth	2.5	3.0	3.3	-1.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.3	8.4	-1.4	-2.9
Schizophrenia vs Biploar Disorder	2.4	3.1	3.7	-1.6	-1.9
Medication: Lansoprazole	2.4	2.7	4.8	-0.8	-2.2
Height	2.3	44.4	75.9	-3.6	-8.7
Medication: Cholesterol lowering	2.2	3.4	5.3	1.3	2.3
HbA1C	2.1	2.4	3.5	1.9	1.1
Heel T-Score	2.1	16.5	18.4	-4.3	-3.8
Peak expiratory flow (PEF)	2.1	4.8	6.7	-1.7	-2.6
Chronic bronchitis/emphysema (mother)	2.1	2.5	2.6	-1.5	-1.6
Ever had hysterectomy (womb removed)	2.0	2.3	2.5	1.5	1.6
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	5.0	-1.3	-2.2
Cardiovascular Disease	1.9	6.3	7.0	2.4	2.6
Relative age voice broke	1.9	3.0	5.0	-1.0	-2.2
Medication: Simvastatin	1.9	2.8	3.3	1.5	1.8
Noisy workplace	1.9	2.3	2.4	1.5	1.5
Medication: Levothyroxine sodium	1.8	3.1	3.1	1.8	1.8
Forced vital capacity (FVC), Best measure	1.8	6.7	10.8	-1.6	-3.3
Had menopause	1.7	2.1	3.0	-1.7	-1.1
BMI	1.6	9.3	10.0	-3.2	-2.9
Trunk fat mass	1.6	7.0	9.2	-2.2	-3.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	8.2	-1.4	-2.9
Ever taken oral contraceptive pill	1.6	1.8	2.1	1.5	1.2
Verbal and Numeric Reasoning (VNR)	1.5	3.6	5.1	-1.4	-2.3
Impedance of arm (right)	1.5	7.2	9.2	3.0	2.3
Blood clot in the leg (DVT)	1.5	1.9	2.3	-1.2	-1.5
Medication: Aspirin	1.5	2.0	2.8	-1.7	-1.1
Arm fat mass (left)	1.5	6.3	7.3	-2.3	-2.7
Commuting to job workplace: Cycle	1.5	1.8	2.0	-1.3	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	2.3	-1.2	-1.5
Alzheimer’s Disease (in father)	1.4	1.5	2.1	-1.0	-1.5
Allergy	1.4	3.3	3.8	1.9	1.7
Arm fat mass (right)	1.4	5.8	7.0	-2.2	-2.6
Medication: Ibuprofen	1.4	1.7	3.0	1.7	0.6
Alcohol intake frequency.	1.4	3.3	4.7	2.2	1.4
Long-standing illness, disability or infirmity	1.4	2.2	2.5	1.6	1.4
Taking other prescription medications	1.3	2.0	2.9	1.1	1.7
Forced vital capacity (FVC)	1.3	5.0	7.9	-1.4	-2.8
Illnesses of father: Heart disease	1.3	1.8	2.4	1.1	1.5
Hair Pigment	1.2	34.5	38.6	-6.2	-5.5
Body mass index (BMI)	1.2	5.0	5.8	-2.4	-2.0
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	6.5	-1.4	-2.5
Birth weight	1.2	2.7	4.5	-0.9	-2.1
Medication for cholesterol	1.2	1.8	2.9	-0.9	-1.7
Mother’s age at death	1.2	1.5	1.8	-1.1	-1.4
Alcohol drinker status: Previous	1.2	1.3	2.2	1.5	0.6
Alzheimer’s Disease (in mother)	1.1	1.2	1.4	-1.2	-1.0
Hearing difficulty/problems: Yes	1.1	1.8	3.1	-1.8	-0.7
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	2.4	1.4	1.6
Whole body fat mass	1.1	4.5	5.9	-1.7	-2.4
Comparative height size at age 10	1.1	6.1	10.4	-1.4	-3.2
Had other major operations	1.0	1.2	1.6	-1.3	-0.9
Fluid intelligence score	1.0	2.1	3.0	-1.1	-1.7
Impedance of arm (left)	1.0	4.4	6.4	2.5	1.5
Comparative body size at age 10	1.0	2.9	4.0	-2.0	-1.3
Number of children fathered	1.0	1.1	1.2	1.1	1.0
Emphysema/chronic bronchitis	1.0	1.2	2.2	1.5	0.3
Medication: Seretide 50 evohaler	1.0	1.2	1.8	-1.3	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.1	2.2	1.5	0.4
Medication: Gliclazide	1.0	1.2	1.2	1.1	1.1
Smoking status: Current	1.0	1.6	2.6	1.6	0.8
Crohns Disease (2017)	0.9	2.1	2.7	-1.2	-1.7
Reaction Time	0.9	1.7	2.3	1.1	1.5
Smoking Status	0.9	2.2	4.0	2.0	0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.3	-1.0	-1.1
Current tobacco smoking	0.9	1.4	2.1	1.4	0.8
Maternal smoking around birth	0.9	1.3	1.4	1.2	1.1
Hair/balding pattern: Pattern 2	0.9	1.1	1.4	-0.9	-1.2
Medication: Ramipril	0.9	1.1	2.1	0.3	1.5
Lung cancer (father)	0.9	1.1	1.7	-1.3	-0.7
Exposure to tobacco smoke outside home	0.9	1.3	2.0	1.4	0.7
Medication: Blood pressure	0.9	1.6	2.4	0.9	1.6
Chest pain or discomfort	0.9	1.2	2.3	-0.5	-1.5
Medication: Aspirin	0.9	1.2	1.9	-1.4	-0.7
Age started oral contraceptive pill	0.9	1.1	1.3	-1.1	-1.0
Lung FVC	0.8	4.3	5.2	-2.3	-1.8
Average weekly spirits intake	0.8	1.0	1.5	-1.2	-0.7
Sensitivity / hurt feelings	0.8	1.4	1.6	-1.3	-1.1
Systolic blood pressure, automated reading	0.8	2.4	3.8	1.0	1.9
Diabetes (mother)	0.8	1.0	1.3	1.2	0.8
Hayfever, allergic rhinitis or eczema	0.8	1.7	2.4	-1.5	-1.0
Waist circumference	0.8	2.8	4.3	-1.2	-2.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	1.7	1.3	1.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.8	0.5	1.3
Ever smoked	0.8	1.4	2.5	-0.6	-1.6
Fed-up feelings	0.7	1.2	1.4	1.0	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.1	-1.1	-0.6
Medication for pain relief, constipation, heartburn	0.7	1.2	1.3	-1.1	-1.0
Friendships satisfaction	0.7	0.9	1.5	-1.2	-0.5
Medication: Bendroflumethiazide	0.7	1.0	1.2	0.9	1.1
Risk taking	0.7	1.1	2.1	0.1	-1.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	0.8	-0.9	-0.9
Bipolar Disorder or Schizophrenia	0.6	1.4	2.4	1.6	0.6
Lupus	0.6	0.9	1.6	-0.3	-1.3
Triglycerides	0.6	1.0	1.5	0.7	1.2
Tanning	0.6	6.9	8.3	2.4	2.9
Relative age of first facial hair	0.6	1.1	1.5	-0.9	-1.2
Diabetes (father)	0.6	0.7	0.8	-0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.6	-1.0	-1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.1	1.0	0.5
Prospective memory result	0.6	0.8	0.8	0.9	0.8
Illnesses of mother	0.6	0.7	1.3	0.3	1.1
Tense / ‘highly strung’	0.6	1.0	1.1	1.0	1.0
Hair/balding pattern: Pattern 4	0.6	1.4	1.6	-1.1	-1.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	0.7	-0.8	-0.8
Average weekly red wine intake	0.6	1.0	1.9	-1.4	-0.2
Hearing aid user	0.6	0.6	1.2	0.3	1.1
High cholesterol (Self-reported)	0.6	1.2	1.9	0.6	1.4
Average weekly beer plus cider intake	0.6	0.8	1.2	-0.7	-1.1
Fractured/broken bones in last 5 years	0.6	0.7	1.2	-0.5	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.2	-0.8	-1.5
Allergy or Eczema	0.5	1.3	2.1	-1.5	-0.7
Medication: Metformin	0.5	0.6	0.8	-0.7	-0.9
Pack years adult smoking proportion	0.5	0.8	0.9	1.0	0.8
Trunk fat percentage	0.5	2.0	2.6	-1.2	-1.6
Townsend deprivation index at recruitment	0.5	0.7	1.2	1.1	0.4
Average weekly fortified wine intake	0.5	0.6	0.7	0.7	0.9
Chronic bronchitis/emphysema (father)	0.5	0.6	0.8	0.9	0.7
Mouth/teeth dental problems	0.5	0.7	1.0	-0.7	-1.0
Falls in the last year	0.5	0.7	1.2	0.3	1.1
Loud music exposure frequency	0.5	0.6	0.8	-0.9	-0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.7	-0.0	1.3
Medication: Paracetamol	0.5	0.9	1.0	1.0	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.2	-0.4	-1.1
Qualifications: College or University degree	0.5	1.6	1.7	-1.3	-1.2
Medication: Allopurinol	0.5	0.7	1.1	1.1	0.5
Mean time to correctly identify matches	0.5	0.9	1.2	0.8	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	-0.3	-1.1
Arm fat percentage (left)	0.5	1.9	1.9	-1.4	-1.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	-0.1	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	0.8	-0.9	-0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	0.6	-0.7	-0.8
Average weekly champagne plus white wine intake	0.5	0.7	1.3	-0.2	-1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.6	0.8	0.8
Medication: Atorvastatin	0.5	0.6	1.1	0.4	1.1
Number of operations (self-reported)	0.5	0.7	1.4	-1.2	-0.2
Diastolic blood pressure, automated reading	0.5	1.6	2.5	0.8	1.6
Ever depressed for a whole week	0.5	0.6	1.2	0.1	-1.1
Pain experienced in last month	0.5	0.8	1.5	-1.2	-0.3
Supplements: Calcium	0.5	0.6	0.7	0.6	0.8
Leg fat mass (left)	0.5	2.0	2.5	-1.2	-1.6
Depression (Nagel 2018)	0.4	0.6	1.2	-0.1	-1.1
Blood Red Count	0.4	3.9	6.2	-2.5	-1.3
Hypothyroidism (self reported)	0.4	0.8	1.1	1.0	0.8
Nervous feelings	0.4	0.8	1.2	-1.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.3	0.1	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	0.9	-0.9	-1.0
Age at first live birth	0.4	0.7	1.4	0.3	1.2
Pulse wave peak to peak time	0.4	0.5	0.8	-0.5	-0.9
Heart disease (mother)	0.4	0.5	1.0	0.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.8	-0.0	0.9
Leg fat mass (right)	0.4	1.7	2.2	-1.1	-1.5
Hypertension (Self-reported)	0.4	1.0	1.7	0.5	1.3
Eye problems/disorders: Cataract	0.4	0.4	0.8	-0.2	0.9
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	0.2	1.1
Medication: Paracetamol	0.4	0.7	1.0	1.0	0.6
Myopia	0.4	0.6	1.0	1.0	0.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.9	-0.4	-1.4
Cholesterol lowering medication	0.4	0.5	0.6	0.8	0.7
Schizophrenia (2018)	0.3	0.6	1.0	0.4	-1.0
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	-0.5	-0.7
Major Depression (MDD)	0.3	0.4	0.4	0.7	-0.6
Age at First Birth	0.3	0.4	0.7	-0.1	-0.9
LDL Cholesterol	0.3	0.5	0.9	0.4	0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.7	0.8	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.5	0.7	-0.5
Age when periods started (menarche)	0.3	0.7	0.9	-0.9	-0.7
High blood pressure	0.3	0.8	1.4	0.4	1.2
Past tobacco smoking	0.3	0.5	0.9	-0.2	1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	0.9	0.2	0.9
Arm fat percentage (right)	0.3	1.2	1.3	-1.1	-1.0
Father’s age at death	0.3	0.4	0.5	-0.7	-0.5
Pulse rate	0.3	0.6	0.6	-0.7	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.4	-1.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.4	0.7	0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.4	-0.6	-0.6
Loneliness, isolation	0.3	0.5	0.7	0.5	-0.8
Qualifications: nursing, teaching	0.3	0.5	0.7	-0.9	-0.4
Guilty feelings	0.3	0.4	0.7	-0.3	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	-0.8	0.1
Commuting to job workplace: Public transport	0.3	0.3	0.5	0.7	0.4
Medication: Lisinopril	0.3	0.4	0.7	0.2	0.8
Alcohol drinker status: Never	0.3	0.4	0.7	0.3	0.8
Irritable Bowel Disease (IBD)	0.2	0.6	1.0	-0.4	-1.0
Crohns Disease (2012)	0.2	0.3	0.4	-0.4	-0.6
HDL Cholesterol	0.2	0.4	0.7	-0.8	-0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	-0.2	0.7
Blood Eosinophil Count	0.2	1.3	1.4	-1.1	-1.2
Chronotype (morning person)	0.2	0.5	0.6	-0.5	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	0.7	-0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.6	0.0
Medication for hormone replacement therapy	0.2	0.2	0.3	0.4	0.6
Vitamin and mineral supplements	0.2	0.3	0.3	-0.5	-0.5
Supplements: Zinc	0.2	0.2	0.4	0.6	0.1
Hand grip strength (right)	0.2	0.4	0.6	-0.4	-0.8
Multivitamins +/- minerals	0.2	0.2	0.3	-0.5	0.4
Supplements: Glucosamine	0.2	0.3	0.5	0.7	0.2
Medication: Atenolol	0.2	0.2	0.2	-0.4	-0.4
High blood pressure (mother)	0.2	0.3	0.3	0.6	-0.5
Neuroticism score	0.2	0.4	0.6	0.8	0.4
Length of working week for main job	0.2	0.2	0.4	0.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	0.7	-0.5
Pulse wave reflection index	0.2	0.2	0.4	-0.2	0.6
Glaucoma (self-reported)	0.2	0.2	0.4	-0.2	-0.6
Leg fat percentage (right)	0.2	0.6	0.7	0.7	0.8
Pulse rate, automated reading	0.2	0.7	0.7	-0.8	-0.8
Supplements: Vitamin C	0.2	0.3	0.3	0.5	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.4	0.7	-0.1
Smoking status: Previous	0.2	0.3	0.6	-0.1	-0.8
Mood swings	0.2	0.4	0.9	0.9	-0.1
Ever had bowel cancer screening	0.2	0.2	0.3	-0.4	0.5
Commuting to job workplace: Walk	0.2	0.2	0.5	0.0	0.7
Back pain experienced in last month	0.2	0.3	0.5	-0.1	-0.7
Mineral and other dietary supplements	0.2	0.3	0.5	-0.4	-0.7
Osteoporosis (self-reported)	0.2	0.3	0.4	0.4	0.6
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.6	0.3
Miserableness	0.2	0.3	0.4	0.6	-0.5
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	-0.4	-0.6
Illnesses of father: High blood pressure	0.2	0.2	0.3	0.4	0.5
Worry (Nagel 2018)	0.1	0.1	0.3	0.0	0.5
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.6	0.1
Ovarian Cancer	0.1	0.2	0.2	0.5	0.4
Prostate Cancer	0.1	0.1	0.2	0.4	0.2
Coronary Artery Disease (CAD)	0.1	0.2	0.2	0.5	0.3
Mean Putamen Volume	0.1	0.1	0.2	0.2	-0.5
Schizophrenia (2014)	0.1	0.3	0.3	0.4	-0.6
Ulcerative Colitis	0.1	0.1	0.2	0.4	0.3
Blood White Count	0.1	0.5	1.0	-0.0	1.0
Respiratory disease	0.1	0.1	0.3	0.0	-0.5
Neuroticism	0.1	0.2	0.3	0.5	-0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.4	0.1
Angina	0.1	0.1	0.2	-0.0	0.4
Medication: Co-codamol	0.1	0.1	0.2	-0.4	0.1
Severe depression (siblings)	0.1	0.1	0.1	0.3	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.5	-0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.1	-0.4
Stomach or abdominal pain in last month	0.1	0.1	0.3	-0.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.3	-0.2
Number of incorrect matches in round	0.1	0.1	0.2	0.5	-0.1
Illnesses of siblings	0.1	0.1	0.3	-0.1	0.5
Time employed in main current job	0.1	0.1	0.2	-0.1	0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	-0.5	-0.3
Number of live births	0.1	0.1	0.3	-0.5	0.0
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	0.1	0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.3	-0.4
Headache pain in last month	0.1	0.2	0.3	-0.3	-0.5
Body fat percentage	0.1	0.5	0.6	-0.6	-0.8
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.0	-0.4
Angina (self-reported)	0.1	0.2	0.3	0.1	0.6
Migraine (self-reported)	0.1	0.1	0.1	-0.4	-0.0
Number of full sisters	0.1	0.2	0.2	-0.3	-0.4
Suffer from ‘nerves’	0.1	0.2	0.2	-0.4	-0.4
Had major operations	0.1	0.1	0.2	-0.5	-0.3
Age at last live birth	0.1	0.2	0.3	-0.3	0.6
Leg pain on walking	0.1	0.1	0.2	-0.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.4	-0.1
Financial situation satisfaction	0.1	0.1	0.1	0.4	-0.3
Medication: Blood pressure	0.1	0.2	0.4	-0.1	0.7
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	-0.3	-0.1
Leg fat percentage (left)	0.1	0.3	0.5	0.4	0.7
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.3	0.4
Pack years of smoking	0.1	0.2	0.2	0.4	0.4
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	0.4	-0.2
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.0	0.1
Breast Cancer	0.0	0.0	0.1	-0.3	-0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.2	0.1
Neuroticism (2016)	0.0	0.0	0.0	0.1	0.1
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.2	0.0
Blood Platelet Count	0.0	0.2	0.4	-0.3	0.6
Lung FEV1/FVC ratio	0.0	0.0	0.0	0.2	0.2
Hand grip strength (left)	0.0	0.1	0.2	-0.2	-0.4
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	0.3	-0.1
Qualifications: None of the above	0.0	0.0	0.0	-0.1	-0.1
Heart attack	0.0	0.0	0.0	-0.1	0.1
Pain all over the body in last month	0.0	0.0	0.0	0.1	0.0
Diabetes (self-reported)	0.0	0.0	0.0	-0.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	0.2	0.0
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	0.3	0.2
Asthma	0.0	0.0	0.0	-0.0	-0.0
Depression (self-reported)	0.0	0.0	0.0	0.0	0.2
Gout (self-reported)	0.0	0.0	0.0	0.0	-0.2
Medication: Amlodipine	0.0	0.0	0.1	-0.0	0.3
High blood pressure (siblings)	0.0	0.0	0.1	0.1	0.3
Number of full brothers	0.0	0.0	0.0	-0.2	-0.1
Worry too long after embarrassment	0.0	0.0	0.0	-0.2	0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.1	0.3
Neck or shoulder pain in last month	0.0	0.0	0.0	0.1	0.0
Medication: Omeprazole	0.0	0.0	0.0	0.0	0.2
Overall health rating	0.0	0.0	0.0	0.1	-0.2
Knee pain experienced in last month	0.0	0.0	0.0	0.1	0.1
Diabetes diagnosed by doctor	0.0	0.0	0.0	-0.2	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.3	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.2	-0.2
Breast cancer (self-reported)	0.0	0.0	0.1	-0.2	0.1
Asthma (self-reported)	0.0	0.1	0.1	-0.2	-0.3
Irritability	0.0	0.0	0.1	0.2	0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.3	-0.1
Heart disease (siblings)	0.0	0.0	0.0	0.1	-0.0

Hub : Genes

LRP5

Models

Trait associations