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chr20:46,551,079-50,188,292

Best TWAS P=1.26e-27 · Best GWAS P=3.77e-26 conditioned to 0.0621

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ARFGEF2	0.09	0.05	lasso	8	0.10	9.2e-13	10.4	-8.9	4.5e-19	-0.82	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CSE1L	0.08	0.07	bslmm	503	0.05	1.7e-06	-5.5	-7.9	3.0e-15	-0.58	0.88	0.12	FALSE
3	GTEx	Artery Aorta	CSE1L	0.12	0.18	lasso	4	0.16	2.9e-09	-5.5	-5.2	1.6e-07	-0.44	0.89	0.11	FALSE
4	GTEx	Artery Tibial	CSE1L	0.12	0.03	lasso	6	0.04	3.8e-04	-5.1	-7.7	1.2e-14	-0.68	0.23	0.76	FALSE
5	GTEx	Brain Nucleus accumbens basal ganglia	BCAS4	0.33	0.01	lasso	7	0.00	4.6e-01	6.1	-6.1	1.0e-09	-0.01	0.02	0.64	FALSE
6	GTEx	Cells Transformed fibroblasts	STAU1	0.08	0.03	lasso	6	0.02	2.3e-02	8.8	9.7	4.9e-22	0.85	0.02	0.93	FALSE
7	GTEx	Colon Sigmoid	ARFGEF2	0.15	0.12	lasso	1	0.07	2.3e-03	7.9	-7.9	2.6e-15	-0.60	0.05	0.62	FALSE
8	GTEx	Colon Sigmoid	CSE1L	0.18	0.12	lasso	11	0.09	4.4e-04	9.3	-9.4	3.4e-21	-0.80	0.11	0.84	FALSE
9	GTEx	Colon Transverse	ARFGEF2	0.11	0.07	enet	12	0.09	2.9e-05	-5.1	-8.7	4.9e-18	-0.78	0.08	0.89	FALSE
10	GTEx	Colon Transverse	CSE1L	0.17	0.01	enet	19	0.03	1.2e-02	5.3	-6.5	7.6e-11	-0.49	0.19	0.14	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	CSE1L	0.17	0.07	lasso	5	0.07	1.6e-03	-5.1	-6.0	1.6e-09	-0.49	0.30	0.23	FALSE
12	GTEx	Esophagus Mucosa	CSE1L	0.09	0.06	lasso	4	0.06	6.9e-05	9.8	-9.4	4.9e-21	-0.80	0.22	0.73	FALSE
13	GTEx	Esophagus Mucosa	ZFAS1	0.15	0.01	enet	16	0.01	8.9e-02	9.8	7.0	3.4e-12	0.69	0.06	0.80	FALSE
14	GTEx	Esophagus Muscularis	CSE1L	0.16	0.14	enet	22	0.12	5.1e-08	-5.1	-5.3	1.3e-07	-0.44	0.96	0.04	FALSE
15	GTEx	Heart Atrial Appendage	CSE1L	0.09	0.07	lasso	5	0.06	9.1e-04	-5.2	-5.6	2.2e-08	-0.42	0.55	0.10	FALSE
16	GTEx	Lung	CSE1L	0.10	0.09	lasso	5	0.08	6.6e-07	8.8	-8.9	4.1e-19	-0.73	0.51	0.48	FALSE
17	GTEx	Muscle Skeletal	PREX1	0.14	0.09	enet	23	0.13	2.5e-12	7.2	5.6	2.5e-08	0.51	0.80	0.20	FALSE
18	GTEx	Muscle Skeletal	CSE1L	0.18	0.19	lasso	9	0.20	4.6e-19	-5.1	-5.3	1.3e-07	-0.42	1.00	0.00	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	ZFAS1	0.16	0.04	enet	19	0.07	1.0e-04	7.2	6.8	8.9e-12	0.69	0.04	0.92	FALSE
20	GTEx	Skin Sun Exposed Lower leg	CSE1L	0.08	0.03	lasso	2	0.03	9.5e-04	9.9	-9.8	1.2e-22	-0.81	0.38	0.32	FALSE
21	GTEx	Skin Sun Exposed Lower leg	ZFAS1	0.07	0.03	enet	14	0.05	5.8e-05	9.9	8.1	5.7e-16	0.77	0.16	0.79	FALSE
22	GTEx	Testis	ARFGEF2	0.20	0.20	lasso	7	0.24	5.4e-11	8.8	-10.2	2.9e-24	-0.91	0.02	0.98	FALSE
23	GTEx	Thyroid	CSE1L	0.20	0.21	enet	15	0.20	2.3e-15	-5.5	-5.4	7.7e-08	-0.44	1.00	0.00	FALSE
24	METSIM	Adipose	ARFGEF2	0.04	0.03	lasso	12	0.02	9.8e-05	10.6	-10.6	2.6e-26	-0.98	0.02	0.98	FALSE
25	METSIM	Adipose	CSE1L	0.05	0.05	lasso	4	0.04	5.3e-07	-5.1	-6.7	2.4e-11	-0.58	0.87	0.13	FALSE
26	NTR	Blood	NCRNA00275	0.07	0.06	lasso	4	0.08	9.7e-25	-3.0	-6.6	5.0e-11	-0.53	1.00	0.00	FALSE
27	NTR	Blood	SNORD12B	0.03	0.05	lasso	8	0.05	1.9e-14	9.9	-10.4	3.1e-25	-0.96	0.05	0.95	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	CSE1L	0.04	0.02	enet	16	0.02	2.8e-03	7.9	-8.7	3.6e-18	-0.72	0.13	0.85	FALSE
29	YFS	Blood	CSE1L	0.06	0.05	enet	21	0.06	2.0e-19	-5.2	-8.0	9.7e-16	-0.60	1.00	0.00	FALSE
30	YFS	Blood	PTPN1	0.37	0.30	enet	21	0.30	1.1e-101	6.3	-7.1	1.5e-12	0.00	0.00	1.00	TRUE
31	YFS	Blood	RNF114	0.08	0.04	bslmm	442	0.04	4.0e-12	4.5	6.1	1.1e-09	-0.02	1.00	0.00	TRUE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	SNAI1	0.09	0.10	lasso	5	0.06	3.1e-04	-5.8	5.8	5.0e-09	-0.03	0.20	0.58	TRUE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CSE1L	0.03	0.05	lasso	1	0.03	9.3e-05	8.8	-8.8	2.0e-18	-0.75	0.28	0.64	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CSE1L	0.05	0.07	blup	50	0.07	3.2e-08	9.2	-9.5	3.2e-21	-0.80	0.37	0.63	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARFGEF2	0.05	0.04	lasso	5	0.05	3.2e-06	10.4	-10.9	1.3e-27	-0.94	0.00	1.00	TRUE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	CSE1L	0.05	0.06	lasso	3	0.05	1.0e-06	-4.9	-5.4	8.4e-08	-0.47	0.94	0.05	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C20orf199	0.04	0.00	enet	8	0.02	6.4e-03	3.5	6.7	1.7e-11	0.62	0.01	0.48	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C20orf199	0.05	0.06	lasso	4	0.06	1.0e-04	9.9	9.9	4.0e-23	0.92	0.00	0.96	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	CSE1L	0.05	0.05	lasso	3	0.06	8.1e-07	-5.5	-5.5	2.9e-08	-0.44	0.94	0.02	FALSE
40	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CSE1L	0.13	0.03	blup	50	0.07	1.4e-03	8.8	-7.5	7.2e-14	-0.60	0.03	0.27	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	CSE1L	0.12	0.20	lasso	2	0.19	7.1e-18	-5.2	-5.2	2.5e-07	-0.43	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	DDX27	0.08	0.05	lasso	3	0.05	1.9e-05	9.9	9.2	2.8e-20	0.85	0.05	0.90	FALSE