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chr3:9,283,299-12,457,119

Best TWAS P=9.73e-16 · Best GWAS P=2.44e-16 conditioned to 0.000542

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	VGLL4	0.04	0.02	blup	511	0.02	7.8e-04	-3.7	-5.2	1.7e-07	0.73	0.14	0.78	FALSE
2	GTEx	Adipose Subcutaneous	CRELD1	0.46	0.16	enet	51	0.27	2.2e-22	-5.2	-7.8	6.7e-15	-0.09	0.14	0.85	FALSE
3	GTEx	Adipose Visceral Omentum	CRELD1	0.19	0.12	lasso	4	0.10	4.1e-06	-5.2	-6.0	2.5e-09	-0.03	0.12	0.59	FALSE
4	GTEx	Artery Aorta	CRELD1	0.30	0.07	lasso	7	0.12	2.4e-07	-5.2	-6.5	6.1e-11	-0.04	0.16	0.81	FALSE
5	GTEx	Artery Aorta	RP11-1020A11.1	0.15	0.01	lasso	3	0.00	4.0e-01	-5.2	-6.6	4.5e-11	-0.02	0.03	0.54	FALSE
6	GTEx	Artery Tibial	CRELD1	0.43	0.15	enet	41	0.21	1.1e-16	-5.2	-6.4	1.7e-10	-0.03	0.15	0.85	FALSE
7	GTEx	Breast Mammary Tissue	CRELD1	0.25	0.19	lasso	6	0.18	2.2e-09	-5.2	-5.2	2.4e-07	0.01	0.14	0.85	FALSE
8	GTEx	Cells Transformed fibroblasts	CRELD1	0.39	0.19	enet	39	0.28	4.5e-21	-5.2	-8.0	9.7e-16	-0.07	0.14	0.85	TRUE
9	GTEx	Cells Transformed fibroblasts	RP11-1020A11.1	0.20	0.10	enet	67	0.09	1.9e-07	-5.2	-7.7	1.4e-14	-0.04	0.14	0.83	FALSE
10	GTEx	Esophagus Mucosa	CRELD1	0.14	0.06	enet	7	0.11	7.7e-08	-5.2	-5.3	1.5e-07	-0.03	0.30	0.41	FALSE
11	GTEx	Esophagus Muscularis	CRELD1	0.21	0.10	lasso	1	0.08	1.7e-05	-5.2	-5.2	2.0e-07	0.00	0.13	0.71	FALSE
12	GTEx	Nerve Tibial	CRELD1	0.17	0.05	enet	9	0.13	2.0e-09	-5.2	-5.9	4.8e-09	-0.04	0.21	0.76	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	CRELD1	0.29	0.07	enet	25	0.13	9.7e-08	-4.0	-7.6	3.3e-14	-0.02	0.49	0.17	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	ATG7	0.10	0.06	enet	12	0.04	2.1e-03	-6.2	-5.2	2.4e-07	0.73	0.05	0.88	FALSE
15	GTEx	Skin Sun Exposed Lower leg	CRELD1	0.29	0.15	enet	36	0.23	8.2e-19	-5.2	-7.5	8.1e-14	-0.06	0.14	0.85	FALSE
16	GTEx	Spleen	VGLL4	0.34	-0.01	enet	30	0.02	9.9e-02	-7.4	-5.5	3.0e-08	0.59	0.05	0.25	TRUE
17	GTEx	Testis	CRELD1	0.22	0.22	lasso	8	0.26	1.1e-11	3.9	-5.5	3.7e-08	-0.02	0.16	0.84	FALSE
18	GTEx	Thyroid	ATG7	0.11	0.02	lasso	3	0.02	1.1e-02	2.9	-5.9	3.3e-09	0.58	0.08	0.65	FALSE
19	METSIM	Adipose	CRELD1	0.23	0.16	bslmm	480	0.21	3.1e-30	-5.2	-6.0	2.5e-09	-0.03	0.17	0.83	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	VGLL4	0.05	0.03	blup	422	0.04	3.7e-06	-7.2	-6.0	2.1e-09	0.80	0.07	0.93	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	SEC13	0.06	0.01	bslmm	606	0.02	1.0e-03	2.8	5.8	5.4e-09	-0.08	0.60	0.02	FALSE
22	YFS	Blood	FANCD2	0.04	0.04	lasso	1	0.04	7.7e-13	5.4	-5.4	6.7e-08	-0.08	0.04	0.96	FALSE
23	YFS	Blood	PRRT3	0.08	0.02	bslmm	469	0.04	7.4e-13	-5.2	-5.3	1.4e-07	-0.09	0.10	0.90	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL17RC	0.07	0.05	blup	52	0.06	7.7e-06	-3.6	5.5	3.3e-08	0.07	0.84	0.02	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	JAGN1	0.04	0.04	blup	49	0.03	2.6e-04	-3.7	-5.7	1.5e-08	-0.09	0.57	0.06	FALSE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	IL17RC	0.03	0.02	blup	53	0.02	8.1e-04	-1.1	5.2	2.6e-07	0.08	0.16	0.04	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CRELD1	0.03	0.00	blup	49	0.01	1.4e-02	-3.7	-5.8	8.2e-09	-0.06	0.01	0.11	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	JAGN1	0.03	0.00	blup	49	0.02	2.1e-03	-3.4	-5.5	3.6e-08	-0.09	0.06	0.12	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC401052	0.06	0.07	enet	6	0.06	3.5e-07	5.6	-5.4	5.9e-08	-0.08	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	VGLL4	0.06	0.01	blup	150	0.02	5.4e-03	-3.4	7.1	1.3e-12	-0.46	0.02	0.68	TRUE
31	The Cancer Genome Atlas	Soft Tissue Sarcoma	CRELD1	0.12	0.01	enet	22	0.04	1.4e-03	-3.4	-5.6	2.7e-08	-0.06	0.02	0.19	FALSE