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chr5:53,702,093-56,923,759

Best TWAS P=2.65e-20 · Best GWAS P=5.24e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCNO	0.06	0.06	enet	12	0.10	1.3e-12	3.73	-5.3	1.0e-07	-0.34	1.00	0.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	DDX4	0.08	0.07	bslmm	390	0.08	1.7e-10	8.53	-8.6	1.3e-17	-0.74	0.05	0.95	TRUE
3	GTEx	Adipose Subcutaneous	SETD9	0.15	0.14	lasso	10	0.16	3.0e-13	-3.98	5.1	3.0e-07	0.02	0.99	0.01	FALSE
4	GTEx	Adipose Visceral Omentum	SETD9	0.16	0.20	lasso	8	0.16	6.8e-09	-4.44	5.6	2.1e-08	0.02	0.53	0.47	FALSE
5	GTEx	Adrenal Gland	SETD9	0.39	0.29	lasso	8	0.35	1.6e-13	-4.44	5.5	4.7e-08	-0.02	0.87	0.13	FALSE
6	GTEx	Artery Aorta	SKIV2L2	0.11	0.04	enet	17	0.08	3.4e-05	4.60	-5.4	6.6e-08	-0.45	0.78	0.09	TRUE
7	GTEx	Artery Coronary	SETD9	0.46	0.40	lasso	7	0.50	4.3e-19	-4.44	5.1	2.9e-07	-0.02	0.99	0.01	FALSE
8	GTEx	Brain Caudate basal ganglia	SETD9	0.31	0.28	lasso	6	0.26	5.0e-08	-4.71	5.2	2.2e-07	0.01	0.93	0.04	FALSE
9	GTEx	Brain Cerebellum	SLC38A9	0.26	0.13	lasso	4	0.10	7.4e-04	8.80	8.3	8.7e-17	0.72	0.04	0.92	FALSE
10	GTEx	Brain Hippocampus	GZMA	0.32	0.00	lasso	6	0.02	1.3e-01	5.24	7.5	4.4e-14	0.44	0.08	0.20	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	SETD9	0.30	0.33	lasso	3	0.32	3.7e-09	-4.44	5.3	1.2e-07	0.02	0.54	0.36	FALSE
12	GTEx	Brain Putamen basal ganglia	SETD9	0.23	0.15	lasso	3	0.14	2.9e-04	-5.58	6.0	2.6e-09	-0.03	0.07	0.69	FALSE
13	GTEx	Breast Mammary Tissue	SETD9	0.30	0.38	lasso	4	0.38	8.2e-21	-4.44	5.2	2.2e-07	0.02	1.00	0.00	FALSE
14	GTEx	Breast Mammary Tissue	GPX8	0.06	0.00	lasso	4	0.01	1.6e-01	4.24	-6.0	1.4e-09	-0.53	0.16	0.32	FALSE
15	GTEx	Breast Mammary Tissue (Male)	GPX8	0.23	0.01	lasso	8	0.02	9.5e-02	-2.91	-5.3	8.9e-08	-0.17	0.07	0.12	TRUE
16	GTEx	Breast Mammary Tissue (Female)	SETD9	0.21	0.12	lasso	11	0.16	1.4e-05	-5.63	6.2	6.4e-10	0.02	0.08	0.86	FALSE
17	GTEx	Breast Mammary Tissue (Female)	GPX8	0.04	0.00	lasso	2	0.03	5.0e-02	8.54	-8.2	3.0e-16	-0.75	0.05	0.27	TRUE
18	GTEx	Cells EBV-transformed lymphocytes	PPAP2A	0.22	0.19	lasso	3	0.15	1.4e-05	6.04	-6.7	2.2e-11	-0.45	0.39	0.11	TRUE
19	GTEx	Cells Transformed fibroblasts	SETD9	0.31	0.42	lasso	6	0.47	5.7e-39	-4.44	5.4	6.5e-08	0.01	1.00	0.00	FALSE
20	GTEx	Colon Sigmoid	SETD9	0.49	0.49	lasso	14	0.53	7.9e-22	-4.68	5.7	1.5e-08	0.03	0.99	0.01	FALSE
21	GTEx	Colon Transverse	SETD9	0.47	0.42	lasso	10	0.43	4.0e-22	-4.44	5.4	6.6e-08	0.01	1.00	0.00	FALSE
22	GTEx	Esophagus Mucosa	SETD9	0.47	0.55	lasso	9	0.58	1.3e-47	-4.44	5.4	5.7e-08	0.01	1.00	0.00	FALSE
23	GTEx	Lung	SETD9	0.33	0.41	lasso	7	0.41	5.8e-34	-4.44	5.3	1.4e-07	0.00	1.00	0.00	FALSE
24	GTEx	Muscle Skeletal	SETD9	0.33	0.42	enet	32	0.44	1.3e-46	-4.44	5.2	2.3e-07	0.02	1.00	0.00	FALSE
25	GTEx	Ovary	SETD9	0.35	0.29	enet	17	0.28	1.1e-07	-4.44	5.2	1.7e-07	-0.01	0.29	0.50	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	SETD9	0.51	0.56	lasso	9	0.58	1.9e-38	-4.44	5.2	2.0e-07	0.02	1.00	0.00	FALSE
27	GTEx	Skin Sun Exposed Lower leg	SETD9	0.40	0.44	lasso	15	0.46	1.8e-42	-4.44	5.3	1.0e-07	0.01	1.00	0.00	FALSE
28	GTEx	Stomach	SETD9	0.35	0.31	lasso	8	0.38	1.9e-19	-4.44	5.8	7.7e-09	-0.01	0.84	0.16	FALSE
29	GTEx	Testis	GZMA	0.10	0.04	lasso	7	0.03	1.4e-02	4.08	5.2	1.5e-07	0.30	0.35	0.06	FALSE
30	GTEx	Testis	SETD9	0.18	0.05	lasso	6	0.11	1.9e-05	-5.21	5.3	1.1e-07	-0.04	0.13	0.82	FALSE
31	GTEx	Testis	CTD-2310F14.1	0.35	0.14	lasso	8	0.15	2.9e-07	-4.68	-5.5	4.4e-08	0.04	0.20	0.78	FALSE
32	GTEx	Uterus	SETD9	0.31	0.15	lasso	8	0.19	1.2e-04	-4.44	5.5	3.1e-08	0.03	0.20	0.30	FALSE
33	GTEx	Vagina	CTD-2310F14.1	0.33	0.02	lasso	7	0.01	1.7e-01	-4.65	5.8	8.4e-09	0.04	0.10	0.07	FALSE
34	GTEx	Whole Blood	SETD9	0.16	0.26	lasso	7	0.27	1.6e-24	-5.21	5.3	1.3e-07	-0.04	0.99	0.01	FALSE
35	METSIM	Adipose	SETD9	0.10	0.14	lasso	17	0.16	9.6e-23	-5.20	5.6	2.1e-08	-0.02	0.96	0.04	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	DDX4	0.07	0.08	lasso	2	0.07	1.5e-09	8.57	-8.7	4.6e-18	-0.72	0.13	0.87	FALSE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C5orf35	0.21	0.28	lasso	7	0.31	8.0e-27	-4.44	5.5	3.2e-08	0.01	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	C5orf35	0.29	0.42	lasso	8	0.46	3.0e-107	-4.44	5.8	8.3e-09	0.01	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPAP2A	0.06	0.03	lasso	1	0.03	1.1e-06	9.16	-9.2	5.2e-20	-1.00	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C5orf35	0.30	0.35	lasso	8	0.40	5.3e-21	-5.22	5.5	4.6e-08	-0.02	0.99	0.01	FALSE
41	The Cancer Genome Atlas	Esophageal Carcinoma	C5orf35	0.19	0.20	lasso	4	0.18	1.9e-06	-5.21	5.3	1.4e-07	-0.06	0.38	0.53	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C5orf35	0.24	0.35	lasso	11	0.37	1.9e-43	-4.44	5.8	9.2e-09	0.01	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCNO	0.03	0.02	enet	3	0.02	1.4e-03	5.27	-5.7	9.3e-09	-0.37	0.12	0.08	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C5orf35	0.35	0.46	lasso	5	0.48	7.8e-62	-4.44	5.5	2.9e-08	0.01	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C5orf35	0.27	0.30	lasso	6	0.36	1.4e-21	-4.44	5.8	6.0e-09	0.01	0.96	0.04	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC38A9	0.04	0.02	enet	7	0.03	6.6e-03	8.43	7.6	3.0e-14	0.68	0.03	0.58	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf35	0.28	0.39	lasso	5	0.40	2.1e-48	-4.44	5.4	7.8e-08	0.01	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C5orf35	0.23	0.39	lasso	11	0.37	1.9e-18	-5.21	5.5	4.3e-08	-0.07	0.95	0.05	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	C5orf35	0.42	0.45	enet	17	0.50	3.2e-67	-4.44	5.5	4.3e-08	0.03	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	MAP3K1	0.02	0.01	blup	83	0.01	9.1e-03	-2.84	-5.5	3.0e-08	-0.03	0.04	0.56	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C5orf35	0.21	0.29	lasso	11	0.33	1.3e-38	-4.44	5.3	9.5e-08	0.00	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C5orf35	0.33	0.35	enet	22	0.36	4.9e-16	-4.44	5.6	2.5e-08	0.01	0.95	0.05	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	C5orf35	0.44	0.58	lasso	9	0.60	1.4e-78	-4.44	5.2	1.9e-07	0.02	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	GZMK	0.04	0.00	blup	40	0.02	7.0e-03	-0.77	-5.3	1.1e-07	-0.24	0.01	0.58	TRUE
55	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C5orf35	0.23	0.08	blup	58	0.17	2.5e-05	-6.70	6.4	1.5e-10	-0.03	0.03	0.94	TRUE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	C5orf35	0.32	0.40	enet	19	0.44	4.8e-35	-4.44	5.5	5.1e-08	0.01	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf35	0.46	0.61	lasso	14	0.63	1.5e-79	-4.44	5.3	8.6e-08	0.01	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	SLC38A9	0.03	0.04	blup	52	0.04	2.0e-04	8.87	9.2	2.7e-20	0.86	0.03	0.97	TRUE
59	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	C5orf35	0.38	0.05	blup	58	0.06	7.0e-03	-4.11	5.6	1.8e-08	0.01	0.04	0.72	FALSE