[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), predicted : ← →

chr6:33,745,071-36,158,878

Best TWAS P=3.21e-17 · Best GWAS P=1.52e-19 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C6orf106	0.29	0.21	bslmm	382	0.23	6.9e-28	7.0	7.2	4.5e-13	-0.01	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FANCE	0.03	0.02	bslmm	420	0.01	1.7e-02	-6.4	-8.3	1.0e-16	0.01	0.29	0.24	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RPL10A	0.21	0.09	enet	30	0.11	2.6e-13	-5.6	-5.3	9.1e-08	-0.01	0.95	0.05	FALSE
4	GTEx	Adipose Subcutaneous	RPL10A	0.06	0.02	enet	27	0.03	2.6e-03	-5.6	-6.1	8.3e-10	-0.08	0.22	0.34	FALSE
5	GTEx	Artery Aorta	RPL10A	0.20	0.12	lasso	5	0.11	8.8e-07	-5.6	-5.8	8.9e-09	-0.05	0.94	0.02	FALSE
6	GTEx	Artery Tibial	C6orf106	0.07	0.02	lasso	4	0.02	8.8e-03	-5.4	6.1	1.4e-09	-0.07	0.10	0.05	FALSE
7	GTEx	Artery Tibial	RPL10A	0.11	0.08	lasso	2	0.09	1.5e-07	-6.1	-6.0	2.5e-09	-0.07	0.98	0.02	FALSE
8	GTEx	Brain Cortex	C6orf106	0.22	0.07	enet	16	0.10	1.1e-03	6.9	7.1	1.1e-12	0.21	0.50	0.04	FALSE
9	GTEx	Colon Transverse	C6orf106	0.15	0.05	lasso	1	0.03	1.5e-02	5.9	5.9	3.6e-09	0.05	0.17	0.04	FALSE
10	GTEx	Colon Transverse	RPL10A	0.12	0.05	lasso	4	0.05	2.5e-03	-6.1	-6.3	3.4e-10	-0.04	0.18	0.39	FALSE
11	GTEx	Esophagus Mucosa	RPL10A	0.14	0.10	enet	17	0.09	2.1e-06	-6.1	-6.9	4.5e-12	-0.09	0.76	0.20	TRUE
12	GTEx	Esophagus Muscularis	RPL10A	0.31	0.19	lasso	5	0.18	4.6e-11	-5.6	-5.9	4.3e-09	-0.03	0.98	0.02	FALSE
13	GTEx	Muscle Skeletal	RPL10A	0.10	0.05	enet	17	0.04	3.9e-05	-5.6	-5.4	5.8e-08	-0.05	0.60	0.19	FALSE
14	GTEx	Nerve Tibial	DEF6	0.15	0.00	lasso	8	0.00	1.6e-01	-6.9	6.5	6.9e-11	0.00	0.08	0.54	FALSE
15	GTEx	Nerve Tibial	C6orf106	0.11	0.07	enet	17	0.07	1.3e-05	6.6	8.4	3.2e-17	0.12	0.70	0.02	TRUE
16	GTEx	Nerve Tibial	RPL10A	0.14	0.12	lasso	3	0.12	9.7e-09	-5.6	-5.5	3.8e-08	-0.03	0.96	0.04	TRUE
17	GTEx	Pancreas	C6orf106	0.14	0.11	enet	11	0.13	2.8e-06	3.0	5.8	8.5e-09	0.11	0.86	0.01	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	TEAD3	0.15	0.06	lasso	5	0.08	2.5e-05	-4.3	-5.2	1.5e-07	-0.09	0.61	0.23	FALSE
19	GTEx	Skin Sun Exposed Lower leg	C6orf106	0.09	0.04	enet	25	0.02	4.6e-03	-3.7	7.8	8.0e-15	0.08	0.38	0.02	TRUE
20	GTEx	Testis	ZNF76	0.15	0.14	enet	8	0.12	4.4e-06	-5.1	5.5	3.6e-08	0.03	0.48	0.49	FALSE
21	GTEx	Thyroid	C6orf106	0.09	0.01	enet	29	0.01	1.1e-01	6.8	6.7	2.7e-11	0.02	0.10	0.03	FALSE
22	GTEx	Thyroid	RPL10A	0.16	0.09	lasso	11	0.07	8.9e-06	-5.1	-5.4	6.6e-08	-0.11	0.72	0.19	FALSE
23	GTEx	Whole Blood	DEF6	0.14	0.05	lasso	4	0.03	9.9e-04	-6.8	6.5	9.4e-11	-0.07	0.12	0.86	FALSE
24	METSIM	Adipose	C6orf106	0.04	0.02	blup	381	0.02	7.7e-04	5.6	5.1	3.0e-07	0.08	0.42	0.04	TRUE
25	METSIM	Adipose	RPL10A	0.18	0.13	lasso	15	0.13	3.4e-19	-5.6	-5.2	1.8e-07	-0.03	1.00	0.00	FALSE
26	NTR	Blood	C6orf106	0.03	0.02	lasso	6	0.02	7.2e-07	6.9	7.5	7.1e-14	0.09	1.00	0.00	FALSE
27	NTR	Blood	ZNF76	0.01	0.00	blup	424	0.00	3.8e-02	-5.8	7.3	3.1e-13	-0.08	0.11	0.55	TRUE
28	ROSMAP	Brain Pre-frontal Cortex	DEF6	0.04	0.02	bslmm	421	0.02	1.8e-03	-6.7	6.4	1.6e-10	-0.09	0.10	0.88	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	ZNF76	0.04	0.00	blup	424	0.02	2.1e-03	-6.8	6.8	7.4e-12	-0.08	0.11	0.80	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	PACSIN1	0.09	0.00	blup	359	0.02	4.5e-04	7.0	6.4	2.0e-10	0.31	0.18	0.06	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	C6orf106	0.30	0.26	bslmm	372	0.33	9.3e-44	6.9	8.3	9.9e-17	0.06	1.00	0.00	FALSE
32	YFS	Blood	ZNF76	0.05	0.08	lasso	4	0.07	6.7e-23	-6.8	6.7	1.9e-11	-0.08	0.13	0.87	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RPL10A	0.03	0.00	blup	54	0.02	6.0e-03	-6.5	-6.8	1.4e-11	0.01	0.01	0.83	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPL10A	0.03	0.00	blup	55	0.01	1.4e-03	-5.6	-5.9	2.9e-09	-0.04	0.05	0.09	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	TCP11	0.03	0.03	blup	49	0.04	6.6e-08	-4.2	-5.4	6.7e-08	0.01	0.95	0.04	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C6orf106	0.04	0.01	blup	68	0.01	2.4e-02	6.7	6.9	4.2e-12	0.11	0.01	0.70	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPL10A	0.07	0.07	lasso	2	0.06	9.9e-08	-6.1	-6.2	6.8e-10	-0.04	0.85	0.15	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TCP11	0.03	0.02	blup	49	0.02	1.7e-03	-3.2	-5.3	1.2e-07	-0.03	0.28	0.33	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	C6orf106	0.04	0.05	lasso	4	0.03	8.1e-05	6.7	6.8	8.0e-12	0.13	0.01	0.99	TRUE
40	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZNF76	0.08	0.05	lasso	10	0.07	4.9e-04	-7.2	-6.3	2.7e-10	-0.01	0.01	0.83	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	C6orf106	0.03	0.03	lasso	3	0.01	7.6e-03	5.6	6.4	1.3e-10	0.11	0.01	0.89	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	RPL10A	0.02	0.02	lasso	2	0.02	3.8e-03	-5.5	-5.5	3.2e-08	-0.02	0.07	0.11	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TCP11	0.03	0.03	blup	49	0.03	3.5e-04	-5.0	-5.7	1.1e-08	-0.03	0.26	0.35	FALSE
44	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C6orf106	0.14	0.07	enet	6	0.06	1.0e-04	6.9	7.0	2.2e-12	0.10	0.01	0.98	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPL10A	0.09	0.03	enet	19	0.07	1.1e-07	-5.6	-6.9	4.0e-12	-0.01	0.83	0.12	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF76	0.03	0.02	lasso	3	0.02	3.5e-03	-5.4	6.0	2.6e-09	-0.01	0.11	0.65	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	C6orf106	0.08	0.00	enet	15	0.05	2.5e-05	-4.0	8.2	2.9e-16	0.00	0.03	0.29	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	RPL10A	0.05	0.07	enet	4	0.04	1.2e-04	-5.6	-6.0	2.1e-09	-0.05	0.71	0.11	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	SCUBE3	0.03	0.01	blup	62	0.03	8.9e-04	-7.2	5.5	3.4e-08	-0.03	0.02	0.85	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	TCP11	0.03	0.02	blup	49	0.02	1.6e-03	-4.8	-5.6	2.6e-08	-0.05	0.04	0.53	FALSE