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chr4:2,152,449-3,943,984

Best TWAS P=1.36e-11 · Best GWAS P=1.23e-10 conditioned to 0.000108

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Cells Transformed fibroblasts	NOP14	0.12	0.06	enet	11	0.09	2.9e-07	-5.0	6.8	1.4e-11	0.17	0.33	0.64	TRUE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	C4orf44	0.03	0.04	lasso	4	0.05	2.9e-06	-4.9	5.9	3.0e-09	0.48	0.50	0.43	TRUE
32	GTEx	Whole Blood	HTT	0.10	0.00	enet	15	0.03	1.4e-03	6.4	6.4	1.9e-10	0.60	0.01	0.92	FALSE
13	GTEx	Colon Transverse	GRK4	0.27	0.25	enet	18	0.25	2.4e-12	-5.4	6.2	4.5e-10	0.15	0.14	0.86	FALSE
50	The Cancer Genome Atlas	Soft Tissue Sarcoma	GRK4	0.08	0.07	blup	77	0.09	4.4e-06	-5.6	6.2	5.4e-10	0.18	0.04	0.96	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GRK4	0.09	0.18	lasso	5	0.20	1.5e-22	-6.0	6.2	6.0e-10	0.16	0.01	0.99	FALSE
17	GTEx	Lung	ADD1	0.09	0.02	enet	6	0.01	3.5e-02	3.9	6.0	1.9e-09	0.17	0.42	0.24	FALSE
19	GTEx	Lung	HTT	0.06	0.00	lasso	4	0.00	5.8e-01	-5.4	6.0	2.5e-09	0.16	0.14	0.17	FALSE
49	The Cancer Genome Atlas	Rectum Adenocarcinoma	GRK4	0.27	0.10	blup	76	0.13	7.3e-04	-5.4	5.9	2.8e-09	0.14	0.04	0.79	FALSE
37	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GRK4	0.09	0.12	blup	76	0.12	1.7e-06	-5.4	5.9	3.6e-09	0.14	0.04	0.96	FALSE
22	GTEx	Pituitary	GRK4	0.17	0.00	enet	6	-0.01	5.6e-01	-6.0	5.9	4.3e-09	0.11	0.07	0.34	FALSE
57	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	GRK4	0.11	0.12	lasso	1	0.10	8.4e-04	-5.9	5.9	4.7e-09	0.10	0.02	0.91	FALSE
43	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GRK4	0.16	0.18	lasso	6	0.20	1.9e-11	-5.3	5.8	6.7e-09	0.15	0.08	0.92	FALSE
51	The Cancer Genome Atlas	Soft Tissue Sarcoma	SH3BP2	0.08	0.03	blup	53	0.02	2.8e-02	5.7	5.8	6.7e-09	0.29	0.00	0.71	FALSE
3	GTEx	Adrenal Gland	GRK4	0.38	0.25	lasso	5	0.29	5.1e-11	-5.4	5.8	7.3e-09	0.13	0.43	0.57	FALSE
25	GTEx	Stomach	GRK4	0.22	0.19	lasso	7	0.19	2.6e-09	-5.6	5.8	7.7e-09	0.10	0.30	0.70	FALSE
1	GTEx	Adipose Subcutaneous	GRK4	0.30	0.39	lasso	6	0.41	1.2e-35	-5.4	5.7	9.0e-09	0.13	0.26	0.74	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C4orf44	0.03	0.02	blup	42	0.02	8.0e-04	-4.9	5.7	9.6e-09	0.48	0.32	0.09	FALSE
52	The Cancer Genome Atlas	Stomach Adenocarcinoma	GRK4	0.17	0.24	lasso	6	0.24	1.2e-17	-5.4	5.7	1.0e-08	0.13	0.05	0.95	FALSE
4	GTEx	Artery Aorta	GRK4	0.29	0.38	enet	11	0.40	1.3e-23	-5.4	5.7	1.1e-08	0.12	0.33	0.67	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	GRK4	0.37	0.23	lasso	9	0.22	2.2e-08	-5.6	5.7	1.3e-08	0.13	0.18	0.82	FALSE
28	GTEx	Thyroid	NOP14-AS1	0.18	0.09	lasso	8	0.11	1.3e-08	-5.4	5.7	1.4e-08	0.14	0.42	0.58	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	GRK4	0.12	0.14	lasso	4	0.14	1.8e-17	-5.5	5.7	1.5e-08	0.10	0.18	0.82	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GRK4	0.09	0.10	lasso	4	0.14	1.4e-11	-5.5	5.6	1.7e-08	0.13	0.07	0.93	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	GRK4	0.11	0.17	lasso	7	0.18	6.7e-36	-5.4	5.6	2.1e-08	0.13	0.05	0.95	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GRK4	0.10	0.14	enet	16	0.14	4.6e-15	-5.4	5.6	2.1e-08	0.12	0.06	0.94	FALSE
18	GTEx	Lung	GRK4	0.26	0.36	lasso	4	0.36	3.3e-29	-5.4	5.6	2.4e-08	0.12	0.41	0.59	FALSE
7	GTEx	Brain Cortex	GRK4	0.25	0.26	lasso	4	0.25	1.7e-07	-5.4	5.6	2.5e-08	0.12	0.47	0.51	FALSE
11	GTEx	Cells Transformed fibroblasts	GRK4	0.32	0.35	lasso	7	0.37	3.1e-29	-5.4	5.6	2.6e-08	0.13	0.24	0.76	FALSE
27	GTEx	Thyroid	GRK4	0.50	0.47	lasso	9	0.48	6.4e-41	-5.4	5.6	2.7e-08	0.11	0.40	0.60	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	GRK4	0.12	0.13	lasso	6	0.14	6.0e-15	-5.4	5.6	2.8e-08	0.12	0.04	0.96	FALSE
6	GTEx	Artery Tibial	GRK4	0.34	0.35	lasso	4	0.35	1.1e-28	-5.4	5.5	2.9e-08	0.13	0.44	0.56	FALSE
33	METSIM	Adipose	GRK4	0.20	0.26	lasso	6	0.25	9.9e-38	-5.4	5.5	2.9e-08	0.12	0.47	0.53	FALSE
2	GTEx	Adipose Visceral Omentum	GRK4	0.32	0.38	lasso	4	0.40	5.5e-22	-5.4	5.5	3.0e-08	0.12	0.32	0.68	FALSE
8	GTEx	Breast Mammary Tissue	GRK4	0.27	0.32	enet	11	0.32	5.3e-17	-5.4	5.5	3.2e-08	0.13	0.41	0.59	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	C4orf10	0.18	0.06	lasso	3	0.07	2.2e-07	-5.6	5.5	3.2e-08	0.12	0.00	0.99	FALSE
9	GTEx	Breast Mammary Tissue (Female)	GRK4	0.23	0.24	lasso	3	0.24	1.1e-07	-5.4	5.5	3.4e-08	0.12	0.30	0.69	FALSE
16	GTEx	Esophagus Muscularis	GRK4	0.29	0.30	enet	7	0.30	2.5e-18	-5.4	5.5	3.6e-08	0.13	0.44	0.56	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	GRK4	0.38	0.43	lasso	4	0.42	9.6e-25	-5.4	5.5	3.6e-08	0.12	0.42	0.58	FALSE
47	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GRK4	0.23	0.32	lasso	5	0.31	1.0e-13	-5.4	5.5	3.6e-08	0.12	0.06	0.94	FALSE
21	GTEx	Ovary	GRK4	0.25	0.19	lasso	8	0.18	3.6e-05	-5.4	5.5	3.9e-08	0.13	0.20	0.28	FALSE
5	GTEx	Artery Coronary	GRK4	0.27	0.24	lasso	3	0.22	6.7e-08	-5.4	5.5	4.0e-08	0.12	0.27	0.73	FALSE
20	GTEx	Nerve Tibial	GRK4	0.29	0.38	lasso	3	0.39	4.6e-29	-5.4	5.5	4.0e-08	0.13	0.43	0.57	FALSE
30	GTEx	Vagina	GRK4	0.27	0.12	lasso	4	0.11	1.6e-03	-5.4	5.5	4.2e-08	0.12	0.15	0.23	FALSE
53	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GRK4	0.08	0.09	lasso	1	0.06	4.2e-03	-5.5	5.5	4.3e-08	0.13	0.03	0.72	FALSE
26	GTEx	Thyroid	NOP14	0.09	0.04	lasso	5	0.03	4.5e-03	-5.2	5.4	5.2e-08	0.13	0.50	0.37	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	GRK4	0.22	0.39	lasso	6	0.38	4.1e-39	-5.4	5.4	5.2e-08	0.13	0.07	0.93	FALSE
15	GTEx	Esophagus Mucosa	GRK4	0.28	0.35	lasso	4	0.34	3.1e-23	-5.4	5.4	5.5e-08	0.12	0.44	0.56	FALSE
12	GTEx	Colon Sigmoid	GRK4	0.26	0.30	lasso	2	0.28	2.6e-10	-5.4	5.4	6.4e-08	0.12	0.29	0.70	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	GRK4	0.18	0.23	blup	76	0.21	3.8e-12	-5.4	5.4	7.7e-08	0.11	0.04	0.96	FALSE
24	GTEx	Spleen	GRK4	0.24	0.16	lasso	5	0.12	4.8e-04	-5.4	5.3	1.0e-07	0.11	0.17	0.34	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GRK4	0.19	0.23	blup	77	0.22	4.2e-24	-5.4	5.3	1.1e-07	0.14	0.08	0.92	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	NOP14	0.09	0.12	blup	57	0.13	1.4e-12	-5.3	5.3	1.4e-07	0.14	0.10	0.90	FALSE
31	GTEx	Whole Blood	GRK4	0.08	0.10	lasso	4	0.10	1.0e-09	-5.4	5.2	1.6e-07	0.09	0.48	0.52	FALSE
29	GTEx	Uterus	GRK4	0.31	0.24	enet	29	0.32	2.5e-07	-5.6	5.2	1.8e-07	0.08	0.14	0.63	FALSE
38	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RNF4	0.14	0.02	blup	47	0.07	3.1e-04	2.7	5.2	2.2e-07	0.19	0.00	0.02	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	GRK4	0.13	0.19	lasso	2	0.19	6.1e-22	-5.4	5.1	2.9e-07	0.12	0.08	0.92	FALSE