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chr17:27,200,734-30,380,381

Best TWAS P=5.54e-18 · Best GWAS P=4.55e-22 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Artery Tibial	RP11-848P1.7	0.54	0.00	lasso	10	0.02	7.3e-03	-5.8	-8.6	5.5e-18	0.47	0.02	0.06	TRUE
19	METSIM	Adipose	TEFM	0.08	0.06	blup	246	0.06	8.8e-10	-9.7	-7.0	2.6e-12	0.57	0.00	1.00	TRUE
2	GTEx	Artery Aorta	ABHD15	0.20	0.03	enet	36	0.06	2.9e-04	-3.6	-6.9	4.7e-12	0.08	0.04	0.41	TRUE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GOSR1	0.15	0.00	blup	56	0.04	1.1e-03	-4.6	6.2	7.3e-10	-0.35	0.03	0.22	TRUE
5	GTEx	Artery Tibial	GOSR1	0.09	0.08	enet	15	0.05	6.9e-05	4.9	5.5	3.3e-08	-0.36	0.92	0.01	TRUE
1	GTEx	Adipose Visceral Omentum	TEFM	0.12	0.02	lasso	14	0.05	1.0e-03	1.4	-5.5	4.2e-08	0.21	0.08	0.09	TRUE
17	METSIM	Adipose	CTD-2349P21.5	0.02	0.00	bslmm	252	0.01	3.0e-03	-5.7	-5.2	2.4e-07	0.33	0.04	0.31	TRUE
7	GTEx	Brain Cerebellum	CRLF3	0.52	0.12	lasso	27	0.20	1.3e-06	-7.7	-7.2	8.4e-13	0.56	0.09	0.74	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	EVI2A	0.08	0.12	lasso	3	0.12	1.3e-12	6.6	-6.6	3.6e-11	0.12	0.02	0.98	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	EVI2A	0.03	0.03	blup	38	0.03	6.9e-07	6.3	-6.6	3.9e-11	0.12	0.02	0.98	FALSE
21	YFS	Blood	EVI2A	0.03	0.05	lasso	4	0.04	1.0e-13	6.6	-6.6	5.0e-11	0.10	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	OMG	0.02	0.02	blup	31	0.02	3.2e-03	6.3	-6.5	6.1e-11	0.15	0.02	0.86	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	EVI2A	0.13	0.03	lasso	4	0.01	1.5e-01	5.9	-6.5	7.8e-11	0.17	0.16	0.04	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	EVI2A	0.03	0.03	blup	38	0.04	3.0e-05	6.3	-6.5	8.7e-11	0.16	0.03	0.97	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	OMG	0.02	0.02	blup	31	0.03	6.9e-04	6.0	-6.5	9.2e-11	0.17	0.02	0.89	FALSE
29	The Cancer Genome Atlas	Esophageal Carcinoma	OMG	0.09	0.09	blup	31	0.11	2.0e-04	6.0	-6.5	9.4e-11	0.18	0.03	0.89	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	EVI2A	0.04	0.06	blup	38	0.06	3.0e-07	6.3	-6.5	1.0e-10	0.15	0.03	0.97	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	OMG	0.02	0.01	blup	32	0.02	4.8e-03	5.9	-6.4	1.2e-10	0.18	0.02	0.85	FALSE
16	GTEx	Whole Blood	EVI2A	0.07	0.04	lasso	4	0.04	2.6e-04	6.3	-6.4	1.3e-10	0.14	0.89	0.00	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EVI2A	0.03	0.03	blup	37	0.03	2.3e-03	6.3	-6.3	2.6e-10	0.10	0.02	0.80	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EVI2A	0.03	0.03	lasso	1	0.02	2.4e-03	6.3	-6.3	3.7e-10	0.10	0.02	0.72	FALSE
18	METSIM	Adipose	NF1	0.04	0.00	blup	396	0.01	5.5e-03	6.6	6.2	4.0e-10	-0.30	0.80	0.02	FALSE
33	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NF1	0.04	0.03	blup	111	0.03	1.3e-02	5.9	6.2	4.5e-10	-0.19	0.07	0.53	FALSE
14	GTEx	Spleen	EVI2A	0.22	0.12	lasso	4	0.07	8.3e-03	6.6	-6.2	7.6e-10	0.17	0.11	0.05	FALSE
10	GTEx	Cells Transformed fibroblasts	OMG	0.06	0.02	lasso	2	0.01	2.5e-02	5.9	6.1	8.5e-10	-0.22	0.14	0.07	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	GOSR1	0.02	0.01	enet	4	0.01	1.7e-02	-5.8	6.1	1.2e-09	-0.27	0.01	0.82	FALSE
4	GTEx	Artery Aorta	CRLF3	0.12	0.03	enet	33	0.06	3.8e-04	1.4	-6.0	2.2e-09	0.53	0.25	0.70	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	OMG	0.03	0.04	lasso	1	0.04	1.1e-08	5.9	-5.9	3.0e-09	0.23	0.10	0.90	FALSE
11	GTEx	Esophagus Muscularis	CRLF3	0.17	0.12	lasso	6	0.18	5.1e-11	2.5	-5.9	3.5e-09	0.46	0.94	0.05	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	OMG	0.05	0.03	lasso	5	0.04	3.6e-05	6.3	-5.8	7.9e-09	0.10	0.02	0.96	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC37B2	0.09	0.00	enet	11	0.03	7.3e-03	4.7	-5.7	1.1e-08	0.47	0.01	0.17	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	OMG	0.05	0.03	blup	32	0.03	5.6e-03	5.9	-5.7	1.3e-08	0.25	0.03	0.38	FALSE
12	GTEx	Muscle Skeletal	TP53I13	0.08	0.02	lasso	4	0.02	2.2e-03	-3.6	5.4	8.4e-08	-0.08	0.03	0.72	FALSE
20	YFS	Blood	CPD	0.18	0.13	enet	38	0.14	8.5e-42	3.8	-5.3	1.0e-07	0.27	1.00	0.00	FALSE
22	YFS	Blood	EVI2B	0.01	0.00	blup	339	0.00	6.4e-02	-0.9	5.2	1.5e-07	-0.26	0.07	0.02	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVI2A	0.04	0.00	blup	37	0.01	1.1e-02	6.3	-5.2	1.8e-07	0.00	0.01	0.52	FALSE
15	GTEx	Spleen	OMG	0.41	0.10	enet	26	0.08	4.5e-03	5.9	5.2	2.2e-07	-0.23	0.64	0.03	FALSE
3	GTEx	Artery Aorta	TEFM	0.13	0.02	enet	34	0.03	5.8e-03	1.4	-5.2	2.3e-07	0.57	0.15	0.78	FALSE
8	GTEx	Brain Cortex	GOSR1	0.20	0.20	enet	7	0.18	1.4e-05	4.4	5.2	2.3e-07	-0.34	0.83	0.03	FALSE
13	GTEx	Pituitary	SUZ12P	0.29	0.23	lasso	9	0.32	6.0e-09	2.4	-5.2	2.6e-07	0.40	0.86	0.07	FALSE