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chr3:9,283,299-10,892,469

Best TWAS P=1.21e-11 · Best GWAS P=2.65e-08 conditioned to 0.163

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Testis	CRELD1	0.22	0.22	lasso	8	0.26	1.1e-11	5.2	-6.8	1.2e-11	0.67	0.08	0.92	TRUE
5	GTEx	Artery Aorta	RP11-1020A11.1	0.15	0.01	lasso	3	0.00	4.0e-01	-5.6	-6.1	1.0e-09	0.91	0.04	0.46	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	AC022007.5	0.05	0.02	blup	515	0.03	2.8e-04	5.3	5.9	4.0e-09	-0.21	0.06	0.94	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	C3orf10	0.05	0.02	blup	49	0.04	9.3e-05	5.1	-5.7	1.0e-08	0.48	0.04	0.96	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	VHL	0.03	0.00	blup	61	0.01	8.2e-02	5.1	-5.7	1.4e-08	0.50	0.02	0.51	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	CIDECP	0.04	0.02	blup	33	0.03	3.8e-04	5.2	5.6	2.3e-08	-0.27	0.04	0.92	FALSE
14	GTEx	Esophagus Muscularis	CRELD1	0.21	0.10	lasso	1	0.08	1.7e-05	-5.6	-5.6	2.6e-08	1.00	0.02	0.96	FALSE
24	METSIM	Adipose	BRK1	0.04	0.02	bslmm	559	0.01	8.9e-03	5.1	-5.5	2.9e-08	0.36	0.10	0.79	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC401052	0.06	0.07	enet	6	0.06	3.5e-07	5.4	-5.5	3.1e-08	0.23	0.02	0.98	FALSE
22	GTEx	Thyroid	BRK1	0.08	0.05	lasso	3	0.04	6.8e-04	5.2	-5.5	3.9e-08	0.29	0.10	0.90	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	AC034193.5	0.15	0.09	enet	11	0.08	3.3e-05	5.2	5.5	4.7e-08	-0.34	0.10	0.88	FALSE
2	GTEx	Adipose Subcutaneous	AC034193.5	0.08	0.07	lasso	4	0.07	2.2e-06	5.2	5.4	5.6e-08	-0.34	0.09	0.91	FALSE
12	GTEx	Cells Transformed fibroblasts	RP11-1020A11.1	0.20	0.10	enet	67	0.09	1.9e-07	-5.6	-5.4	6.0e-08	0.66	0.02	0.98	FALSE
26	YFS	Blood	FANCD2	0.04	0.04	lasso	1	0.04	7.7e-13	5.4	-5.4	6.2e-08	0.22	0.04	0.96	FALSE
3	GTEx	Adipose Visceral Omentum	CRELD1	0.19	0.12	lasso	4	0.10	4.1e-06	-5.6	-5.4	6.6e-08	0.91	0.02	0.94	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C3orf10	0.03	0.05	lasso	5	0.04	3.4e-05	5.3	-5.4	8.3e-08	0.34	0.03	0.97	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	CIDECP	0.08	0.03	lasso	1	0.02	7.8e-04	5.3	5.3	9.5e-08	-0.22	0.02	0.43	FALSE
7	GTEx	Breast Mammary Tissue	CRELD1	0.25	0.19	lasso	6	0.18	2.2e-09	-5.6	-5.3	1.3e-07	1.00	0.02	0.98	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	CYCSP10	0.19	0.01	lasso	5	-0.01	6.6e-01	5.2	-5.3	1.3e-07	0.30	0.06	0.33	FALSE
4	GTEx	Artery Aorta	AC034193.5	0.12	0.01	lasso	3	0.00	1.6e-01	5.2	5.3	1.4e-07	-0.29	0.07	0.73	FALSE
16	GTEx	Pancreas	BRK1	0.22	0.20	lasso	9	0.15	6.3e-07	5.1	-5.3	1.4e-07	0.28	0.13	0.87	FALSE
21	GTEx	Thyroid	CIDECP	0.11	0.12	lasso	2	0.11	1.1e-08	5.2	5.3	1.4e-07	-0.33	0.08	0.92	FALSE
23	GTEx	Whole Blood	BRK1	0.08	0.06	lasso	2	0.04	1.2e-04	5.0	-5.2	1.7e-07	0.27	0.14	0.84	FALSE
9	GTEx	Cells Transformed fibroblasts	CRELD1	0.39	0.19	enet	39	0.28	4.5e-21	-5.6	-5.2	2.0e-07	0.79	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C3orf10	0.05	0.04	lasso	3	0.04	1.4e-03	5.1	-5.2	2.1e-07	0.25	0.04	0.86	FALSE
6	GTEx	Artery Tibial	AC034193.5	0.10	0.08	lasso	1	0.06	1.2e-05	5.2	5.2	2.4e-07	-0.28	0.10	0.89	FALSE
13	GTEx	Esophagus Mucosa	VHL	0.14	0.00	lasso	1	0.00	2.9e-01	5.2	-5.2	2.4e-07	0.28	0.06	0.47	FALSE
18	GTEx	Skin Sun Exposed Lower leg	AC034193.5	0.09	0.11	lasso	2	0.09	8.7e-08	5.2	5.2	2.4e-07	-0.28	0.09	0.90	FALSE
10	GTEx	Cells Transformed fibroblasts	AC034193.5	0.12	0.05	lasso	3	0.05	1.2e-04	5.2	5.2	2.5e-07	-0.26	0.09	0.90	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BRK1	0.05	0.04	lasso	1	0.03	1.2e-04	5.1	-5.1	2.8e-07	0.27	0.11	0.82	FALSE
19	GTEx	Skin Sun Exposed Lower leg	BRK1	0.13	0.11	lasso	8	0.10	8.6e-09	5.1	-5.1	2.8e-07	0.27	0.13	0.86	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	C3orf10	0.01	0.01	blup	49	0.01	9.4e-03	5.0	-5.1	2.8e-07	0.24	0.03	0.69	FALSE
11	GTEx	Cells Transformed fibroblasts	BRK1	0.30	0.29	lasso	9	0.29	1.1e-21	5.1	-5.1	2.9e-07	0.27	0.14	0.86	FALSE
15	GTEx	Muscle Skeletal	BRK1	0.10	0.12	lasso	2	0.13	1.7e-12	5.1	-5.1	2.9e-07	0.27	0.14	0.86	FALSE