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chr5:129,797,129-132,425,049

Best TWAS P=3.01e-18 · Best GWAS P=2.03e-14 conditioned to 0.00304

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	HINT1	0.10	0.07	enet	16	0.06	8.8e-06	-7.1	-8.7	3.0e-18	0.43	0.06	0.92	TRUE
40	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-3.6	6.0	2.4e-09	-0.43	0.07	0.92	TRUE
7	GTEx	Artery Tibial	HINT1	0.11	0.04	enet	18	0.06	1.0e-05	-6.8	-8.6	1.0e-17	0.73	0.08	0.86	FALSE
3	GTEx	Artery Aorta	HINT1	0.07	0.07	enet	8	0.06	4.7e-04	-7.0	-7.5	7.6e-14	0.51	0.10	0.46	FALSE
12	GTEx	Cells Transformed fibroblasts	HINT1	0.10	0.06	lasso	2	0.05	2.1e-04	-6.8	-7.5	8.9e-14	0.53	0.08	0.89	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	HINT1	0.07	0.04	lasso	2	0.01	1.8e-02	-6.6	-6.6	3.2e-11	0.50	0.00	0.98	FALSE
36	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	5.9	-6.6	3.6e-11	0.47	0.96	0.04	FALSE
33	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	6.1	6.4	1.6e-10	-0.60	0.97	0.03	FALSE
6	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	6.0	6.4	1.7e-10	-0.54	0.97	0.03	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	LYRM7	0.03	0.01	enet	10	0.02	7.5e-04	-3.9	6.2	7.6e-10	-0.66	0.02	0.78	FALSE
25	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	6.0	6.1	8.1e-10	-0.54	0.88	0.07	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	6.1	6.1	1.3e-09	-0.59	0.00	1.00	FALSE
24	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	5.9	6.0	1.5e-09	-0.48	0.36	0.08	FALSE
27	GTEx	Testis	RAPGEF6	0.50	0.35	lasso	4	0.32	6.5e-15	-5.7	-6.0	1.5e-09	0.54	1.00	0.00	FALSE
19	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	5.2	6.0	1.7e-09	-0.59	0.97	0.02	FALSE
15	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	5.9	-6.0	1.8e-09	0.51	0.95	0.05	FALSE
2	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	6.0	6.0	2.0e-09	-0.53	0.94	0.03	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	-5.7	-6.0	2.0e-09	0.36	0.83	0.03	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	6.1	5.9	3.1e-09	-0.52	0.00	1.00	FALSE
31	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	5.9	-5.9	3.8e-09	0.47	0.96	0.04	FALSE
34	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	5.9	-5.9	3.8e-09	0.47	0.96	0.04	FALSE
5	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	5.8	5.9	4.1e-09	-0.51	0.47	0.04	FALSE
14	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	6.0	5.8	6.1e-09	-0.45	0.98	0.02	FALSE
22	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	6.0	-5.8	6.2e-09	0.45	0.96	0.04	FALSE
23	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	5.8	-5.8	6.3e-09	0.47	0.96	0.04	FALSE
9	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	6.1	5.7	1.0e-08	-0.46	0.98	0.02	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	5.9	-5.7	1.4e-08	0.53	0.40	0.21	FALSE
17	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	5.9	-5.6	1.9e-08	0.50	0.96	0.04	FALSE
16	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	6.0	5.5	2.8e-08	-0.50	0.90	0.05	FALSE
10	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	-4.7	5.4	6.7e-08	-0.46	0.50	0.07	FALSE
32	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	5.8	-5.4	6.8e-08	0.30	0.93	0.03	FALSE
4	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	-4.6	5.3	9.8e-08	-0.29	0.64	0.02	FALSE
20	GTEx	Pancreas	P4HA2	0.22	0.21	lasso	13	0.20	5.3e-09	-4.3	5.3	1.1e-07	-0.54	0.77	0.21	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	5.9	-5.3	1.1e-07	0.35	0.55	0.04	FALSE
29	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	6.0	5.3	1.1e-07	-0.42	0.72	0.03	FALSE
26	GTEx	Testis	PDLIM4	0.15	0.07	enet	8	0.05	2.5e-03	-4.7	5.3	1.4e-07	-0.45	0.25	0.11	FALSE
18	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	-4.7	5.2	1.5e-07	-0.54	0.98	0.02	FALSE
30	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-4.3	-5.2	1.6e-07	0.26	0.59	0.03	FALSE
28	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	6.0	5.2	1.7e-07	-0.47	0.78	0.03	FALSE
13	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-4.3	-5.2	2.1e-07	0.34	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-4.7	-5.2	2.3e-07	0.40	0.07	0.93	FALSE
8	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	5.8	-5.2	2.4e-07	0.43	0.96	0.04	FALSE