Best TWAS P=2.52e-11 · Best GWAS P=7.18e-12 conditioned to 0.138
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | GTEx | Cells Transformed fibroblasts | SLC25A37 | 0.13 | 0.05 | lasso | 5 | 0.04 | 3.0e-04 | -6.7 | 6.7 | 2.5e-11 | -0.83 | 0.01 | 0.99 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | CHMP7 | 0.10 | 0.02 | lasso | 6 | 0.04 | 5.4e-05 | 3.6 | -6.0 | 1.6e-09 | 0.08 | 0.01 | 0.96 | TRUE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC25A37 | 0.11 | 0.09 | lasso | 5 | 0.09 | 7.8e-10 | -5.7 | -6.2 | 4.3e-10 | 0.67 | 0.79 | 0.21 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOXL2 | 0.16 | 0.03 | lasso | 4 | 0.05 | 1.2e-03 | -5.3 | 6.2 | 6.8e-10 | -0.50 | 0.10 | 0.13 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHMP7 | 0.03 | 0.03 | blup | 89 | 0.01 | 3.8e-02 | 3.6 | -5.9 | 4.8e-09 | 0.03 | 0.05 | 0.32 | FALSE |
| 3 | YFS | Blood | R3HCC1 | 0.03 | 0.01 | lasso | 6 | 0.01 | 5.3e-04 | -5.3 | 5.4 | 6.2e-08 | -0.01 | 0.60 | 0.27 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC25A37 | 0.08 | 0.05 | lasso | 5 | 0.05 | 4.8e-07 | -4.8 | 5.2 | 2.1e-07 | -0.70 | 0.05 | 0.95 | FALSE |